TR 365 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
PENTAERYTHRITOL TETRANITRATE
NTP Experiment-Test: 05023-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/04/94
Route: DOSED FEED Time: 00:40:08
Facility: TSI Mason Research
Chemical CAS #: 78-11-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.62% 1.25%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 13 15 18
Dead 3 2 1
Natural Death 1
Survivors
Terminal Sacrifice 33 33 31
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (10) (50)
Intestine Small, Duodenum (48) (11) (49)
Adenocarcinoma 1 (2%)
Intestine Small, Ileum (46) (13) (49)
Liver (50) (50) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Pancreas (50) (17) (49)
Acinus, Adenoma 1 (6%) 1 (2%)
Pharynx (1) (1)
Palate, Squamous Cell Carcinoma 1 (100%)
Salivary Glands (50) (13) (49)
Sarcoma, Metastatic, Skin 1 (2%)
Stomach, Glandular (50) (11) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (10) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (12) (49)
Adrenal Gland, Medulla (49) (12) (49)
Pheochromocytoma Benign 1 (2%) 4 (8%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (49) (17) (48)
Adenoma 1 (2%) 1 (6%)
Parathyroid Gland (43) (36) (44)
Adenoma 1 (2%)
Pituitary Gland (50) (30) (49)
Pars Distalis, Adenoma 16 (32%) 13 (43%) 18 (37%)
Page 2
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.62% 1.25%
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pars Distalis, Adenoma, Multiple 3 (6%) 1 (3%) 5 (10%)
Pars Distalis, Carcinoma 1 (2%)
Thyroid Gland (50) (48) (50)
Sarcoma, Metastatic, Skin 1 (2%)
Bilateral, C-Cell, Adenoma 2 (4%)
C-Cell, Adenoma 5 (10%) 3 (6%) 4 (8%)
C-Cell, Carcinoma 1 (2%) 1 (2%) 3 (6%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (39) (12) (41)
Adenoma 5 (13%) 4 (33%) 6 (15%)
Carcinoma 1 (8%) 1 (2%)
Bilateral, Adenoma 2 (17%)
Ovary (50) (15) (50)
Granulosa Cell Tumor Benign 1 (7%)
Uterus (50) (48) (50)
Leiomyosarcoma 1 (2%)
Polyp Stromal 8 (16%) 9 (19%) 12 (24%)
Bilateral, Polyp Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (10) (50)
Lymph Node (50) (17) (49)
Lymph Node, Mandibular (46) (11) (47)
Lymph Node, Mesenteric (49) (12) (48)
Spleen (49) (26) (50)
Thymus (46) (10) (44)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (46) (34) (48)
Adenocarcinoma 1 (3%) 2 (4%)
Adenoma 1 (2%)
Fibroadenoma 18 (39%) 15 (44%) 18 (38%)
Fibroadenoma, Multiple 9 (20%) 8 (24%) 11 (23%)
Page 3
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.62% 1.25%
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Skin (49) (15) (50)
Keratoacanthoma 1 (2%)
Subcutaneous Tissue, Fibroma 4 (8%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (7%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (7%)
Subcutaneous Tissue, Hemangioma 1 (7%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10) (50)
Astrocytoma Malignant 1 (10%)
Spinal Cord (1) (1) (1)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Nose (50) (10) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2) (2)
Basosquamous Tumor Benign 1 (50%)
Fibrosarcoma 1 (50%)
Zymbal's Gland (36) (37) (35)
Adenoma 2 (6%)
Carcinoma 1 (3%) 1 (3%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Urinary Bladder (49) (10) (49)
Page 4
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.62% 1.25%
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 14 (28%) 14 (28%) 9 (18%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.62% 1.25%
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 46 47 50
Total Primary Neoplasms 95 83 106
Total Animals with Benign Neoplasms 43 40 47
Total Benign Neoplasms 78 61 84
Total Animals with Malignant Neoplasms 17 20 18
Total Malignant Neoplasms 17 22 22
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 2 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 20 16 16
Dead 8 5 5
Survivors
Terminal Sacrifice 21 28 29
Moribund 1
Terminal Sacrifice 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (46) (8) (47)
Intestine Large, Colon (47) (10) (48)
Intestine Small, Duodenum (48) (9) (46)
Intestine Small, Ileum (47) (7) (47)
Intestine Small, Jejunum (45) (9) (46)
Liver (49) (50) (50)
Hepatocellular Carcinoma 1 (2%)
Neoplastic Nodule 2 (4%) 1 (2%)
Mesentery (5) (2) (9)
Pancreas (49) (49) (48)
Mixed Tumor Benign 1 (2%)
Acinus, Adenoma 1 (2%) 4 (8%) 3 (6%)
Acinus, Adenoma, Multiple 1 (2%)
Salivary Glands (48) (13) (49)
Stomach, Forestomach (49) (14) (48)
Stomach, Glandular (48) (15) (47)
Tongue (2) (1)
Squamous Cell Papilloma 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (15) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (18) (48)
Adrenal Gland, Medulla (49) (18) (48)
Pheochromocytoma Malignant 2 (11%) 3 (6%)
Pheochromocytoma Benign 12 (24%) 8 (44%) 11 (23%)
Page 7
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Bilateral, Pheochromocytoma Benign 7 (14%) 4 (8%)
Islets, Pancreatic (49) (45) (47)
Adenoma 6 (12%) 2 (4%) 1 (2%)
Adenoma, Multiple 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (49) (20) (50)
Pars Distalis, Adenoma 13 (27%) 11 (55%) 11 (22%)
Pars Distalis, Adenoma, Multiple 1 (5%) 1 (2%)
Thyroid Gland (49) (15) (50)
C-Cell, Adenoma 5 (10%) 2 (13%) 7 (14%)
C-Cell, Carcinoma 2 (4%)
Follicular Cell, Adenoma 1 (7%)
Follicular Cell, Carcinoma 1 (2%) 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (48) (13) (50)
Preputial Gland (46) (22) (50)
Adenoma 11 (24%) 10 (45%) 13 (26%)
Carcinoma 3 (7%) 1 (5%) 1 (2%)
Bilateral, Adenoma 1 (5%)
Bilateral, Carcinoma 1 (5%)
Prostate (48) (13) (50)
Adenocarcinoma 1 (2%)
Seminal Vesicle (49) (23) (50)
Testes (49) (50) (50)
Bilateral, Interstitial Cell, Adenoma 39 (80%) 36 (72%) 42 (84%)
Interstitial Cell, Adenoma 8 (16%) 8 (16%) 7 (14%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (10) (50)
Lymph Node (48) (30) (50)
Lymph Node, Mandibular (46) (20) (49)
Liposarcoma, Metastatic, Skin 1 (2%)
Lymph Node, Mesenteric (47) (15) (48)
Spleen (48) (36) (50)
Thymus (36) (17) (45)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (37) (9) (38)
Adenocarcinoma 1 (3%) 1 (3%)
Fibroadenoma 3 (8%) 1 (11%) 1 (3%)
Fibroadenoma, Multiple 1 (3%)
Skin (48) (18) (50)
Basal Cell Adenoma 1 (2%)
Keratoacanthoma 3 (6%) 1 (2%)
Squamous Cell Carcinoma 1 (6%)
Squamous Cell Papilloma 1 (2%) 1 (6%) 1 (2%)
Scrotal, Fibroma 1 (6%)
Subcutaneous Tissue, Fibroma 4 (8%) 2 (11%) 1 (2%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%)
Subcutaneous Tissue, Liposarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Tail, Keratoacanthoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (48) (50)
Astrocytoma Malignant 2 (4%)
Cerebellum, Carcinoma, Metastatic, Zymbal's
Gland 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (28) (50)
Alveolar/Bronchiolar Adenoma 3 (6%) 3 (11%) 4 (8%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (4%)
Carcinoma Adenosquamous 1 (2%)
Liposarcoma, Metastatic, Skin 1 (2%)
Nose (47) (10) (50)
Chondroma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (3)
Sarcoma 1 (100%)
Eye (5) (9) (6)
Zymbal's Gland (49) (45) (41)
Adenoma 1 (2%)
Carcinoma 2 (4%) 2 (5%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50)
Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (46) (10) (48)
Adenocarcinoma, Metastatic, Prostate 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 29 (58%) 27 (54%) 20 (40%)
Mesothelioma Malignant 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05023-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 09/04/94
Route: DOSED FEED Time: 00:40:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 2.5% 5.0%
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 49 50
Total Primary Neoplasms 163 133 151
Total Animals with Benign Neoplasms 49 48 50
Total Benign Neoplasms 123 96 114
Total Animals with Malignant Neoplasms 33 32 31
Total Malignant Neoplasms 40 37 37
Total Animals with Metastatic Neoplasms 1 1 2
Total Metastatic Neoplasm 2 1 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 62330-62330/62330
--multipart-boundary--