TR 365 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason PENTAERYTHRITOL TETRANITRATE DATE: 09/04/94
EXPERIMENT: 05023 TEST: 01 TIME: 00:50:33
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01CP9561901 ROUTE: DOSED FEED NTP C#: 55743
PATHOLOGIST: K. MURTHY CAS: 78-11-5
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason PENTAERYTHRITOL TETRANITRATE DATE: 09/04/94
EXPERIMENT: 05023 TEST: 01 TIME: 00:50:33
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9561901 ROUTE: DOSED FEED NTP C#: 55743
PATHOLOGIST: K. MURTHY CAS: 78-11-5
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason PENTAERYTHRITOL TETRANITRATE DATE: 09/04/94
EXPERIMENT: 05023 TEST: 01 TIME: 00:50:33
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9561901 ROUTE: DOSED FEED NTP C#: 55743
PATHOLOGIST: K. MURTHY CAS: 78-11-5
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF PENTAERYTHRITOL TETRANITRATE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Malignant
Pheochromocytoma: Benign, Complex, Malignant, NOS
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
Islets, Pancreatic Adenoma
Carcinoma or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Testes Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
Thyroid Gland: Follicular Cell
Carcinoma or Adenoma
All Organs Malignant and Benign Tumors
====================================================================================================
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/49 (39%) 8/18 (44%) 15/48 (31%) | 2/49 (4%) 0/12 (0%) 4/49 (8%) |
|ADJUSTED (b) | 61.3% 69.9% 43.1% | 5.7% 0.0% 12.3% |
|TERMINAL (d) | 11/22 (50%) 4/6 (67%) 9/27 (33%) | 1/32 (3%) 0/1 (0%) 3/30 (10%) |
|FIRST INCIDENCE (DAYS) | 479 641 589 | 710 --- 680 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.072N P=0.286N P=0.092N | P=0.229 P=0.488N P=0.311 |
|INCIDENTAL TUMOR | P=0.138N P=0.168 P=0.200N | P=0.286 P=0.842N P=0.366 |
|LOGISTIC REGRESSION | P=0.153N P=0.222 P=0.198N | P=0.250 P=0.876N P=0.328 |
|COCHRAN-ARMITAGE | P=0.254N | P=0.252 |
|FISHER EXACT | P=0.442 P=0.287N | P=0.643N P=0.339 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 2/18 (11%) 3/48 (6%) | 0/49 (0%) 0/12 (0%) 0/49 (0%) |
|ADJUSTED (b) | 0.0% 33.3% 6.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 2/6 (33%) 0/27 (0%) | 0/32 (0%) 0/1 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | --- 735 (T) 560 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.132 P=0.030 * P=0.154 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.075 P=0.030 * P=0.044 * | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.079 P=0.028 * P=0.032 * | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.103 | (e) |
|FISHER EXACT | P=0.069 P=0.117 | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/49 (39%) 10/18 (56%) 18/48 (38%) | 2/49 (4%) 0/12 (0%) 4/49 (8%) |
|ADJUSTED (b) | 61.3% 100.0% 46.7% | 5.7% 0.0% 12.3% |
|TERMINAL (d) | 11/22 (50%) 6/6 (100%) 9/27 (33%) | 1/32 (3%) 0/1 (0%) 3/30 (10%) |
|FIRST INCIDENCE (DAYS) | 479 641 560 | 710 --- 680 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.190N P=0.580N P=0.230N | P=0.229 P=0.488N P=0.311 |
|INCIDENTAL TUMOR | P=0.356N P=0.024 * P=0.490N | P=0.286 P=0.842N P=0.366 |
|LOGISTIC REGRESSION | P=0.384N P=0.037 * P=0.504N | P=0.250 P=0.876N P=0.328 |
|COCHRAN-ARMITAGE | P=0.492N | P=0.252 |
|FISHER EXACT | P=0.171 P=0.532N | P=0.643N P=0.339 |
|=================================================================================================================================|
| |
|Brain |
| Astrocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/48 (0%) 2/50 (4%) | 0/50 (0%) 1/10 (10%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 6.2% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/27 (0%) 0/29 (0%) | 0/33 (0%) 0/0 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 725 | --- 200 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.127 (e) P=0.315 | P=0.729N P=0.500 (e) |
|INCIDENTAL TUMOR | P=0.124 (e) P=0.283 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.123 (e) P=0.300 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.099 | P=0.700N |
|FISHER EXACT | (e) P=0.253 | P=0.167 (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/46 (24%) 11/22 (50%) 13/50 (26%) | 5/39 (13%) 6/12 (50%) 6/41 (15%) |
|ADJUSTED (b) | 32.0% 67.6% 36.7% | 16.3% 72.0% 21.4% |
|TERMINAL (d) | 2/20 (10%) 5/8 (63%) 8/29 (28%) | 3/26 (12%) 5/7 (71%) 6/28 (21%) |
|FIRST INCIDENCE (DAYS) | 564 622 641 | 682 585 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.390N P=0.408 P=0.461N | P=0.496 P=0.042 * P=0.537 |
|INCIDENTAL TUMOR | P=0.458 P=0.037 * P=0.506 | P=0.496 P=0.001 ** P=0.563 |
|LOGISTIC REGRESSION | P=0.479 P=0.030 * P=0.484 | P=0.505 P=0.004 ** P=0.552 |
|COCHRAN-ARMITAGE | P=0.472 | P=0.489 |
|FISHER EXACT | P=0.032 * P=0.501 | P=0.013 * P=0.536 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/46 (7%) 2/22 (9%) 1/50 (2%) | 0/39 (0%) 1/12 (8%) 1/41 (2%) |
|ADJUSTED (b) | 7.6% 14.7% 2.4% | 0.0% 14.3% 3.6% |
|TERMINAL (d) | 0/20 (0%) 1/8 (13%) 0/29 (0%) | 0/26 (0%) 1/7 (14%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 479 672 681 | --- 735 (T) 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.157N P=0.526N P=0.239N | P=0.374 P=0.241 P=0.515 |
|INCIDENTAL TUMOR | P=0.298N P=0.559 P=0.530N | P=0.374 P=0.241 P=0.515 |
|LOGISTIC REGRESSION | P=0.325N P=0.591 P=0.510N | P=0.374 P=0.241 P=0.515 |
|COCHRAN-ARMITAGE | P=0.214N | P=0.366 |
|FISHER EXACT | P=0.524 P=0.278N | P=0.235 P=0.512 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/46 (30%) 13/22 (59%) 14/50 (28%) | 5/39 (13%) 7/12 (58%) 6/41 (15%) |
|ADJUSTED (b) | 37.2% 79.0% 38.2% | 16.3% 86.0% 21.4% |
|TERMINAL (d) | 2/20 (10%) 6/8 (75%) 8/29 (28%) | 3/26 (12%) 6/7 (86%) 6/28 (21%) |
|FIRST INCIDENCE (DAYS) | 479 622 641 | 682 585 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.225N P=0.487 P=0.285N | P=0.501 P=0.012 * P=0.537 |
|INCIDENTAL TUMOR | P=0.492N P=0.031 * P=0.587 | P=0.500 P<0.001 ** P=0.563 |
|LOGISTIC REGRESSION | P=0.490N P=0.026 * P=0.563 | P=0.510 P<0.001 ** P=0.552 |
|COCHRAN-ARMITAGE | P=0.424N | P=0.492 |
|FISHER EXACT | P=0.023 * P=0.485N | P=0.003 ** P=0.536 |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/49 (12%) 3/45 (7%) 1/47 (2%) | 1/49 (2%) 1/17 (6%) 0/48 (0%) |
|ADJUSTED (b) | 25.0% 10.3% 3.4% | 3.0% 14.3% 0.0% |
|TERMINAL (d) | 5/22 (23%) 2/26 (8%) 1/29 (3%) | 1/33 (3%) 1/7 (14%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 660 696 735 (T) | 735 (T) 735 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.014N* P=0.165N P=0.024N* | P=0.369N P=0.389 P=0.512N |
|INCIDENTAL TUMOR | P=0.016N* P=0.188N P=0.026N* | P=0.369N P=0.389 P=0.512N |
|LOGISTIC REGRESSION | P=0.017N* P=0.198N P=0.028N* | P=0.369N P=0.389 P=0.512N |
|COCHRAN-ARMITAGE | P=0.042N* | P=0.354N |
|FISHER EXACT | P=0.288N P=0.062N | P=0.452 P=0.505N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/49 (12%) 3/45 (7%) 2/47 (4%) | 1/49 (2%) 1/17 (6%) 0/48 (0%) |
|ADJUSTED (b) | 25.0% 10.3% 6.1% | 3.0% 14.3% 0.0% |
|TERMINAL (d) | 5/22 (23%) 2/26 (8%) 1/29 (3%) | 1/33 (3%) 1/7 (14%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 660 696 711 | 735 (T) 735 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.041N* P=0.165N P=0.064N | P=0.369N P=0.389 P=0.512N |
|INCIDENTAL TUMOR | P=0.048N* P=0.188N P=0.073N | P=0.369N P=0.389 P=0.512N |
|LOGISTIC REGRESSION | P=0.051N P=0.198N P=0.075N | P=0.369N P=0.389 P=0.512N |
|COCHRAN-ARMITAGE | P=0.102N | P=0.354N |
|FISHER EXACT | P=0.288N P=0.148N | P=0.452 P=0.505N |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 6.9% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/29 (0%) 2/29 (7%) | 0/33 (0%) 0/33 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 735 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.117 (e) P=0.300 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.117 (e) P=0.300 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.117 (e) P=0.300 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.097 | (e) |
|FISHER EXACT | (e) P=0.253 | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 7.4% 0.0% 3.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/29 (0%) 1/29 (3%) | 0/33 (0%) 0/33 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 711 --- 735 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.287N P=0.189N P=0.402N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.302N P=0.253N P=0.420N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.307N P=0.214N P=0.428N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.355N | (e) |
|FISHER EXACT | P=0.242N P=0.492N | (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 11.6% 0.0% 3.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/22 (5%) 0/29 (0%) 1/29 (3%) | 0/33 (0%) 0/33 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 711 --- 735 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.120N P=0.083N P=0.213N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.130N P=0.113N P=0.225N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.126N P=0.094N P=0.220N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.171N | (e) |
|FISHER EXACT | P=0.117N P=0.301N | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 11.6% 0.0% 3.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/22 (5%) 0/29 (0%) 1/29 (3%) | 0/33 (0%) 0/33 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 711 --- 735 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.120N P=0.083N P=0.213N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.130N P=0.113N P=0.225N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.126N P=0.094N P=0.220N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.171N | (e) |
|FISHER EXACT | P=0.117N P=0.301N | (e) (e) |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/49 (6%) 3/28 (11%) 4/50 (8%) | 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 11.1% 17.9% 10.4% | 6.1% 3.0% 0.0% |
|TERMINAL (d) | 2/22 (9%) 2/13 (15%) 1/29 (3%) | 2/33 (6%) 1/33 (3%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 577 711 674 | 735 (T) 735 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.573 P=0.515 P=0.641 | P=0.151N P=0.500N P=0.252N |
|INCIDENTAL TUMOR | P=0.514 P=0.386 P=0.549 | P=0.151N P=0.500N P=0.252N |
|LOGISTIC REGRESSION | P=0.477 P=0.368 P=0.486 | P=0.151N P=0.500N P=0.252N |
|COCHRAN-ARMITAGE | P=0.438 | P=0.143N |
|FISHER EXACT | P=0.378 P=0.511 | P=0.500N P=0.247N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/49 (8%) 3/28 (11%) 4/50 (8%) | 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 15.5% 17.9% 10.4% | 6.1% 3.0% 0.0% |
|TERMINAL (d) | 3/22 (14%) 2/13 (15%) 1/29 (3%) | 2/33 (6%) 1/33 (3%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 577 711 674 | 735 (T) 735 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.414N P=0.631 P=0.490N | P=0.151N P=0.500N P=0.252N |
|INCIDENTAL TUMOR | P=0.471N P=0.514 P=0.581N | P=0.151N P=0.500N P=0.252N |
|LOGISTIC REGRESSION | P=0.504N P=0.490 P=0.638N | P=0.151N P=0.500N P=0.252N |
|COCHRAN-ARMITAGE | P=0.559N | P=0.143N |
|FISHER EXACT | P=0.502 P=0.631N | P=0.500N P=0.247N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 4.5% 0.0% 2.1% | 0.0% 2.9% 6.3% |
|TERMINAL (d) | 1/22 (5%) 0/29 (0%) 0/29 (0%) | 0/33 (0%) 0/33 (0%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 735 (T) --- 589 | --- 715 724 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.634N P=0.445N P=0.722N | P=0.133 P=0.494 P=0.230 |
|INCIDENTAL TUMOR | P=0.604 P=0.445N P=0.705 | P=0.184 P=0.473 P=0.267 |
|LOGISTIC REGRESSION | P=0.632 P=0.445N P=0.717 | P=0.139 P=0.498 P=0.229 |
|COCHRAN-ARMITAGE | P=0.669N | P=0.143 |
|FISHER EXACT | P=0.500N P=0.753N | P=0.500 P=0.247 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 1/50 (2%) | 1/50 (2%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 4.5% 0.0% 2.1% | 2.9% 2.9% 6.3% |
|TERMINAL (d) | 1/22 (5%) 0/29 (0%) 0/29 (0%) | 0/33 (0%) 0/33 (0%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 735 (T) --- 589 | 723 715 724 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.634N P=0.445N P=0.722N | P=0.359 P=0.754 P=0.482 |
|INCIDENTAL TUMOR | P=0.604 P=0.445N P=0.705 | P=0.458 P=0.738 P=0.567 |
|LOGISTIC REGRESSION | P=0.632 P=0.445N P=0.717 | P=0.109 P=0.761 P=0.490 |
|COCHRAN-ARMITAGE | P=0.669N | P=0.378 |
|FISHER EXACT | P=0.500N P=0.753N | P=0.753N P=0.500 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 1/50 (2%) 1/50 (2%) | 27/50 (54%) 23/50 (46%) 29/50 (58%) |
|ADJUSTED (b) | 14.9% 3.4% 2.9% | 68.9% 56.6% 68.5% |
|TERMINAL (d) | 2/22 (9%) 1/29 (3%) 0/29 (0%) | 21/33 (64%) 16/33 (48%) 18/31 (58%) |
|FIRST INCIDENCE (DAYS) | 534 735 (T) 718 | 441 443 441 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.063N P=0.125N P=0.120N | P=0.307 P=0.295N P=0.336 |
|INCIDENTAL TUMOR | P=0.121N P=0.191N P=0.225N | P=0.419 P=0.341N P=0.461 |
|LOGISTIC REGRESSION | P=0.094N P=0.172N P=0.181N | P=0.363 P=0.289N P=0.399 |
|COCHRAN-ARMITAGE | P=0.101N | P=0.380 |
|FISHER EXACT | P=0.181N P=0.181N | P=0.274N P=0.420 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 1/50 (2%) 1/50 (2%) | 27/50 (54%) 23/50 (46%) 29/50 (58%) |
|ADJUSTED (b) | 14.9% 3.4% 2.9% | 68.9% 56.6% 68.5% |
|TERMINAL (d) | 2/22 (9%) 1/29 (3%) 0/29 (0%) | 21/33 (64%) 16/33 (48%) 18/31 (58%) |
|FIRST INCIDENCE (DAYS) | 534 735 (T) 718 | 441 443 441 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.063N P=0.125N P=0.120N | P=0.307 P=0.295N P=0.336 |
|INCIDENTAL TUMOR | P=0.121N P=0.191N P=0.225N | P=0.419 P=0.341N P=0.461 |
|LOGISTIC REGRESSION | P=0.094N P=0.172N P=0.181N | P=0.363 P=0.289N P=0.399 |
|COCHRAN-ARMITAGE | P=0.101N | P=0.380 |
|FISHER EXACT | P=0.181N P=0.181N | P=0.274N P=0.420 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 1/50 (2%) 2/50 (4%) | 27/50 (54%) 24/50 (48%) 29/50 (58%) |
|ADJUSTED (b) | 19.1% 3.4% 5.0% | 68.9% 57.9% 68.5% |
|TERMINAL (d) | 3/22 (14%) 1/29 (3%) 0/29 (0%) | 21/33 (64%) 16/33 (48%) 18/31 (58%) |
|FIRST INCIDENCE (DAYS) | 534 735 (T) 589 | 441 443 441 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.085N P=0.062N P=0.144N | P=0.306 P=0.364N P=0.336 |
|INCIDENTAL TUMOR | P=0.181N P=0.098N P=0.304N | P=0.429 P=0.424N P=0.461 |
|LOGISTIC REGRESSION | P=0.139N P=0.091N P=0.248N | P=0.363 P=0.363N P=0.399 |
|COCHRAN-ARMITAGE | P=0.133N | P=0.381 |
|FISHER EXACT | P=0.102N P=0.218N | P=0.345N P=0.420 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Papilloma Squamous or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 6.8% 3.4% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/22 (5%) 1/29 (3%) 0/29 (0%) | 0/33 (0%) 0/33 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 629 735 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.108N P=0.428N P=0.200N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.156N P=0.497N P=0.295N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.133N P=0.485N P=0.251N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.142N | (e) |
|FISHER EXACT | P=0.500N P=0.247N | (e) (e) |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 6.8% 3.4% 0.0% | 3.0% 0.0% 0.0% |
|TERMINAL (d) | 1/22 (5%) 1/29 (3%) 0/29 (0%) | 1/33 (3%) 0/33 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 629 735 (T) --- | 735 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.108N P=0.428N P=0.200N | P=0.280N P=0.500N P=0.512N |
|INCIDENTAL TUMOR | P=0.156N P=0.497N P=0.295N | P=0.280N P=0.500N P=0.512N |
|LOGISTIC REGRESSION | P=0.133N P=0.485N P=0.251N | P=0.280N P=0.500N P=0.512N |
|COCHRAN-ARMITAGE | P=0.142N | P=0.272N |
|FISHER EXACT | P=0.500N P=0.247N | P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 5/49 (10%) 3/48 (6%) | 0/50 (0%) 1/17 (6%) 1/49 (2%) |
|ADJUSTED (b) | 4.5% 17.2% 9.0% | 0.0% 14.3% 3.2% |
|TERMINAL (d) | 1/22 (5%) 5/29 (17%) 2/29 (7%) | 0/33 (0%) 1/7 (14%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 735 (T) 735 (T) 669 | --- 735 (T) 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.382 P=0.172 P=0.416 | P=0.341 P=0.196 P=0.488 |
|INCIDENTAL TUMOR | P=0.372 P=0.172 P=0.396 | P=0.341 P=0.196 P=0.488 |
|LOGISTIC REGRESSION | P=0.376 P=0.172 P=0.366 | P=0.341 P=0.196 P=0.488 |
|COCHRAN-ARMITAGE | P=0.255 | P=0.348 |
|FISHER EXACT | P=0.102 P=0.301 | P=0.254 P=0.495 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/49 (27%) 12/20 (60%) 12/50 (24%) | 19/50 (38%) 14/30 (47%) 23/49 (47%) |
|ADJUSTED (b) | 43.5% 100.0% 31.1% | 47.3% 58.2% 61.2% |
|TERMINAL (d) | 8/22 (36%) 7/7 (100%) 5/29 (17%) | 13/33 (39%) 7/14 (50%) 16/30 (53%) |
|FIRST INCIDENCE (DAYS) | 534 501 622 | 504 547 442 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.196N P=0.091 P=0.257N | P=0.175 P=0.328 P=0.201 |
|INCIDENTAL TUMOR | P=0.477N P=0.003 ** P=0.562N | P=0.204 P=0.250 P=0.227 |
|LOGISTIC REGRESSION | P=0.398N P=0.004 ** P=0.517N | P=0.203 P=0.260 P=0.236 |
|COCHRAN-ARMITAGE | P=0.430N | P=0.213 |
|FISHER EXACT | P=0.010 ** P=0.477N | P=0.298 P=0.243 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/49 (27%) 12/20 (60%) 12/50 (24%) | 19/50 (38%) 14/30 (47%) 24/49 (49%) |
|ADJUSTED (b) | 43.5% 100.0% 31.1% | 47.3% 58.2% 62.1% |
|TERMINAL (d) | 8/22 (36%) 7/7 (100%) 5/29 (17%) | 13/33 (39%) 7/14 (50%) 16/30 (53%) |
|FIRST INCIDENCE (DAYS) | 534 501 622 | 504 547 442 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.196N P=0.091 P=0.257N | P=0.134 P=0.328 P=0.157 |
|INCIDENTAL TUMOR | P=0.477N P=0.003 ** P=0.562N | P=0.145 P=0.250 P=0.158 |
|LOGISTIC REGRESSION | P=0.398N P=0.004 ** P=0.517N | P=0.152 P=0.260 P=0.181 |
|COCHRAN-ARMITAGE | P=0.430N | P=0.159 |
|FISHER EXACT | P=0.010 ** P=0.477N | P=0.298 P=0.184 |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 10.5% 0.0% 5.4% | 3.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/29 (0%) 1/29 (3%) | 1/33 (3%) 0/33 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 672 --- 562 | 735 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.305N P=0.084N P=0.386N | P=0.280N P=0.500N P=0.512N |
|INCIDENTAL TUMOR | P=0.388N P=0.128N P=0.493N | P=0.280N P=0.500N P=0.512N |
|LOGISTIC REGRESSION | P=0.430N P=0.115N P=0.568N | P=0.280N P=0.500N P=0.512N |
|COCHRAN-ARMITAGE | P=0.390N | P=0.272N |
|FISHER EXACT | P=0.121N P=0.500N | P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 4.5% 5.8% 3.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/22 (5%) 1/29 (3%) 1/29 (3%) | 0/33 (0%) 0/33 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 735 (T) 645 735 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.539N P=0.582 P=0.700N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.541N P=0.555 P=0.700N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.580N P=0.523 P=0.700N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.622N | (e) |
|FISHER EXACT | P=0.500 P=0.753N | (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 3/50 (6%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 14.5% 5.8% 8.8% | 3.0% 0.0% 0.0% |
|TERMINAL (d) | 1/22 (5%) 1/29 (3%) 2/29 (7%) | 1/33 (3%) 0/33 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 672 645 562 | 735 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.298N P=0.239N P=0.362N | P=0.280N P=0.500N P=0.512N |
|INCIDENTAL TUMOR | P=0.360N P=0.316N P=0.451N | P=0.280N P=0.500N P=0.512N |
|LOGISTIC REGRESSION | P=0.424N P=0.316N P=0.508N | P=0.280N P=0.500N P=0.512N |
|COCHRAN-ARMITAGE | P=0.417N | P=0.272N |
|FISHER EXACT | P=0.339N P=0.500N | P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 2/50 (4%) | 4/50 (8%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 12.8% 5.7% 5.8% | 10.5% 0.0% 3.2% |
|TERMINAL (d) | 0/22 (0%) 1/29 (3%) 1/29 (3%) | 2/33 (6%) 0/33 (0%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 660 641 681 | 639 --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.164N P=0.260N P=0.220N | P=0.090N P=0.067N P=0.193N |
|INCIDENTAL TUMOR | P=0.218N P=0.379N P=0.235N | P=0.092N P=0.066N P=0.207N |
|LOGISTIC REGRESSION | P=0.235N P=0.373N P=0.241N | P=0.084N P=0.062N P=0.180N |
|COCHRAN-ARMITAGE | P=0.252N | P=0.083N |
|FISHER EXACT | P=0.339N P=0.339N | P=0.059N P=0.181N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) | 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 4.4% | 2.0% 3.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/29 (0%) 0/29 (0%) | 0/33 (0%) 1/33 (3%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 622 | 504 735 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.118 (e) P=0.289 | P=0.341N P=0.758 P=0.504N |
|INCIDENTAL TUMOR | P=0.068 (e) P=0.166 | P=0.262N P=0.686 P=0.362N |
|LOGISTIC REGRESSION | P=0.064 (e) P=0.143 | P=0.317N P=0.733N P=0.419N |
|COCHRAN-ARMITAGE | P=0.095 | P=0.332N |
|FISHER EXACT | (e) P=0.247 | P=0.753N P=0.500N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 2/50 (4%) 4/50 (8%) | 5/50 (10%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 15.4% 5.7% 9.9% | 12.3% 3.0% 5.8% |
|TERMINAL (d) | 0/22 (0%) 1/29 (3%) 1/29 (3%) | 2/33 (6%) 1/33 (3%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | 660 641 622 | 504 735 (T) 689 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.293N P=0.158N P=0.341N | P=0.147N P=0.110N P=0.234N |
|INCIDENTAL TUMOR | P=0.407N P=0.248N P=0.434N | P=0.114N P=0.134N P=0.186N |
|LOGISTIC REGRESSION | P=0.553N P=0.250N P=0.642N | P=0.131N P=0.091N P=0.205N |
|COCHRAN-ARMITAGE | P=0.424N | P=0.135N |
|FISHER EXACT | P=0.218N P=0.500N | P=0.102N P=0.218N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 2/50 (4%) | 1/50 (2%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 2.9% 0.0% 4.4% | 2.0% 3.0% 2.7% |
|TERMINAL (d) | 0/22 (0%) 0/29 (0%) 0/29 (0%) | 0/33 (0%) 1/33 (3%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 660 --- 622 | 504 735 (T) 689 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.423 P=0.473N P=0.580 | P=0.632 P=0.758 P=0.758 |
|INCIDENTAL TUMOR | P=0.324 P=0.516N P=0.451 | P=0.533N P=0.686 P=0.645N |
|LOGISTIC REGRESSION | P=0.290 P=0.509N P=0.376 | P=0.635N P=0.733N P=0.738N |
|COCHRAN-ARMITAGE | P=0.360 | P=0.641 |
|FISHER EXACT | P=0.500N P=0.500 | P=0.753N P=0.753N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 47/49 (96%) 44/50 (88%) 49/50 (98%) | |
|ADJUSTED (b) | 100.0% 95.6% 100.0% | |
|TERMINAL (d) | 22/22 (100%) 27/29 (93%) 29/29 (100%) | |
|FIRST INCIDENCE (DAYS) | 479 562 560 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.076N P=0.034N* P=0.082N | |
|INCIDENTAL TUMOR | P=0.484N P=0.125N P=0.674 | |
|LOGISTIC REGRESSION | P=0.507N P=0.101N P=0.734 | |
|COCHRAN-ARMITAGE | P=0.407 | |
|FISHER EXACT | P=0.141N P=0.492 | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/49 (10%) 2/15 (13%) 7/50 (14%) | 7/50 (14%) 3/48 (6%) 4/50 (8%) |
|ADJUSTED (b) | 18.5% 4.9% 22.1% | 20.1% 9.4% 11.1% |
|TERMINAL (d) | 3/22 (14%) 0/2 (0%) 5/29 (17%) | 6/33 (18%) 3/32 (9%) 2/31 (6%) |
|FIRST INCIDENCE (DAYS) | 589 645 709 | 644 735 (T) 662 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.505 P=0.543N P=0.571 | P=0.217N P=0.170N P=0.286N |
|INCIDENTAL TUMOR | P=0.466 P=0.427 P=0.500 | P=0.213N P=0.168N P=0.284N |
|LOGISTIC REGRESSION | P=0.429 P=0.468 P=0.512 | P=0.203N P=0.172N P=0.268N |
|COCHRAN-ARMITAGE | P=0.337 | P=0.198N |
|FISHER EXACT | P=0.524 P=0.394 | P=0.176N P=0.262N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 0/15 (0%) 2/50 (4%) | 1/50 (2%) 1/48 (2%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 0.0% 5.5% | 2.5% 3.1% 9.3% |
|TERMINAL (d) | 0/22 (0%) 0/2 (0%) 1/29 (3%) | 0/33 (0%) 1/32 (3%) 2/31 (6%) |
|FIRST INCIDENCE (DAYS) | --- --- 641 | 647 735 (T) 709 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.152 (e) P=0.292 | P=0.191 P=0.757 P=0.291 |
|INCIDENTAL TUMOR | P=0.093 (e) P=0.172 | P=0.233 P=0.742 P=0.351 |
|LOGISTIC REGRESSION | P=0.125 (e) P=0.218 | P=0.200 P=0.755 P=0.302 |
|COCHRAN-ARMITAGE | P=0.128 | P=0.203 |
|FISHER EXACT | (e) P=0.253 | P=0.742 P=0.309 |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/49 (10%) 2/15 (13%) 9/50 (18%) | 8/50 (16%) 4/48 (8%) 7/50 (14%) |
|ADJUSTED (b) | 18.5% 4.9% 26.9% | 22.1% 12.5% 19.8% |
|TERMINAL (d) | 3/22 (14%) 0/2 (0%) 6/29 (21%) | 6/33 (18%) 4/32 (13%) 4/31 (13%) |
|FIRST INCIDENCE (DAYS) | 589 645 641 | 644 735 (T) 662 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.303 P=0.543N P=0.368 | P=0.477N P=0.193N P=0.532N |
|INCIDENTAL TUMOR | P=0.242 P=0.427 P=0.253 | P=0.443N P=0.196N P=0.495N |
|LOGISTIC REGRESSION | P=0.226 P=0.468 P=0.279 | P=0.453N P=0.197N P=0.509N |
|COCHRAN-ARMITAGE | P=0.165 | P=0.443N |
|FISHER EXACT | P=0.524 P=0.205 | P=0.199N P=0.500N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 1/15 (7%) 0/50 (0%) | 0/50 (0%) 0/48 (0%) 2/50 (4%) |
|ADJUSTED (b) | 2.6% 2.9% 0.0% | 0.0% 0.0% 6.5% |
|TERMINAL (d) | 0/22 (0%) 0/2 (0%) 0/29 (0%) | 0/33 (0%) 0/32 (0%) 2/31 (6%) |
|FIRST INCIDENCE (DAYS) | 641 696 --- | --- --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.279N P=0.724N P=0.462N | P=0.089 (e) P=0.224 |
|INCIDENTAL TUMOR | P=0.403N P=0.564 P=0.674N | P=0.089 (e) P=0.224 |
|LOGISTIC REGRESSION | P=0.363N P=0.480 P=0.586N | P=0.089 (e) P=0.224 |
|COCHRAN-ARMITAGE | P=0.346N | P=0.097 |
|FISHER EXACT | P=0.417 P=0.495N | (e) P=0.247 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 2/15 (13%) 0/50 (0%) | 0/50 (0%) 0/48 (0%) 3/50 (6%) |
|ADJUSTED (b) | 2.6% 51.4% 0.0% | 0.0% 0.0% 9.7% |
|TERMINAL (d) | 0/22 (0%) 1/2 (50%) 0/29 (0%) | 0/33 (0%) 0/32 (0%) 3/31 (10%) |
|FIRST INCIDENCE (DAYS) | 641 696 --- | --- --- 735 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.296N P=0.328 P=0.462N | P=0.033 * (e) P=0.110 |
|INCIDENTAL TUMOR | P=0.391N P=0.123 P=0.674N | P=0.033 * (e) P=0.110 |
|LOGISTIC REGRESSION | P=0.363N P=0.069 P=0.586N | P=0.033 * (e) P=0.110 |
|COCHRAN-ARMITAGE | P=0.371N | P=0.038 * |
|FISHER EXACT | P=0.134 P=0.495N | (e) P=0.121 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Tongue |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 6.8% 3.4% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/22 (5%) 1/29 (3%) 0/29 (0%) | 0/33 (0%) 0/33 (0%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | 629 735 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.108N P=0.428N P=0.200N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.156N P=0.497N P=0.295N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.133N P=0.485N P=0.251N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.142N | (e) |
|FISHER EXACT | P=0.500N P=0.247N | (e) (e) |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 8/50 (16%) 10/50 (20%) 12/50 (24%) |
|ADJUSTED (b) | | 19.7% 26.0% 31.4% |
|TERMINAL (d) | | 4/33 (12%) 6/33 (18%) 7/31 (23%) |
|FIRST INCIDENCE (DAYS) | | 504 585 508 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.182 P=0.400 P=0.217 |
|INCIDENTAL TUMOR | | P=0.181 P=0.373 P=0.204 |
|LOGISTIC REGRESSION | | P=0.195 P=0.410 P=0.237 |
|COCHRAN-ARMITAGE | | P=0.191 |
|FISHER EXACT | | P=0.398 P=0.227 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 3.4% 0.0% | 0.0% 0.0% 5.8% |
|TERMINAL (d) | 0/22 (0%) 1/29 (3%) 0/29 (0%) | 0/33 (0%) 0/33 (0%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | --- 735 (T) --- | --- --- 689 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.698N P=0.555 (e) | P=0.093 (e) P=0.233 |
|INCIDENTAL TUMOR | P=0.698N P=0.555 (e) | P=0.115 (e) P=0.267 |
|LOGISTIC REGRESSION | P=0.698N P=0.555 (e) | P=0.094 (e) P=0.235 |
|COCHRAN-ARMITAGE | P=0.731 | P=0.095 |
|FISHER EXACT | P=0.500 (e) | (e) P=0.247 |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 4.3% 5.9% | 0.0% 3.0% 2.3% |
|TERMINAL (d) | 0/22 (0%) 0/29 (0%) 1/29 (3%) | 0/33 (0%) 1/33 (3%) 0/31 (0%) |
|FIRST INCIDENCE (DAYS) | --- 562 687 | --- 735 (T) 634 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.221 P=0.255 P=0.308 | P=0.330 P=0.500 P=0.505 |
|INCIDENTAL TUMOR | P=0.113 P=0.125 P=0.294 | P=0.271 P=0.500 P=0.388 |
|LOGISTIC REGRESSION | P=0.124 P=0.225 P=0.263 | P=0.335 P=0.500 P=0.515 |
|COCHRAN-ARMITAGE | P=0.176 | P=0.334 |
|FISHER EXACT | P=0.247 P=0.247 | P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 7.6% 5.9% | 0.0% 3.0% 8.0% |
|TERMINAL (d) | 0/22 (0%) 1/29 (3%) 1/29 (3%) | 0/33 (0%) 1/33 (3%) 1/31 (3%) |
|FIRST INCIDENCE (DAYS) | --- 562 687 | --- 735 (T) 634 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.260 P=0.150 P=0.308 | P=0.059 P=0.500 P=0.122 |
|INCIDENTAL TUMOR | P=0.150 P=0.074 P=0.294 | P=0.054 P=0.500 P=0.104 |
|LOGISTIC REGRESSION | P=0.161 P=0.110 P=0.263 | P=0.060 P=0.500 P=0.122 |
|COCHRAN-ARMITAGE | P=0.202 | P=0.060 |
|FISHER EXACT | P=0.121 P=0.247 | P=0.500 P=0.121 |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 29/50 (58%) 27/50 (54%) 20/50 (40%) | 14/50 (28%) 14/50 (28%) 9/50 (18%) |
|ADJUSTED (b) | 70.9% 62.0% 54.4% | 34.3% 31.7% 23.5% |
|TERMINAL (d) | 11/22 (50%) 13/29 (45%) 13/29 (45%) | 7/33 (21%) 4/33 (12%) 4/31 (13%) |
|FIRST INCIDENCE (DAYS) | 577 501 589 | 610 547 506 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.009N** P=0.157N P=0.011N* | P=0.202N P=0.566 P=0.225N |
|INCIDENTAL TUMOR | P=0.038N* P=0.529N P=0.037N* | P=0.124N P=0.577 P=0.142N |
|LOGISTIC REGRESSION | P=0.035N* P=0.528N P=0.036N* | P=0.152N P=0.583 P=0.171N |
|COCHRAN-ARMITAGE | P=0.045N* | P=0.148N |
|FISHER EXACT | P=0.420N P=0.055N | P=0.588N P=0.171N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 49/50 (98%) 48/50 (96%) 50/50 (100%) | 43/50 (86%) 40/50 (80%) 47/50 (94%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 89.5% 88.7% 95.9% |
|TERMINAL (d) | 22/22 (100%) 29/29 (100%) 29/29 (100%) | 28/33 (85%) 28/33 (85%) 29/31 (94%) |
|FIRST INCIDENCE (DAYS) | 479 501 560 | 441 443 441 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.054N P=0.061N P=0.064N | P=0.183 P=0.378N P=0.214 |
|INCIDENTAL TUMOR | P=0.695N P=0.572N (e) | P=0.153 P=0.394N P=0.160 |
|LOGISTIC REGRESSION | P=0.603N P=0.449N (e) | P=0.139 P=0.325N P=0.157 |
|COCHRAN-ARMITAGE | P=0.360 | P=0.150 |
|FISHER EXACT | P=0.500N P=0.500 | P=0.298N P=0.159 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 33/50 (66%) 32/50 (64%) 31/50 (62%) | 17/50 (34%) 20/50 (40%) 18/50 (36%) |
|ADJUSTED (b) | 75.3% 69.0% 66.5% | 39.7% 44.6% 42.6% |
|TERMINAL (d) | 12/22 (55%) 15/29 (52%) 14/29 (48%) | 8/33 (24%) 9/33 (27%) 8/31 (26%) |
|FIRST INCIDENCE (DAYS) | 479 501 560 | 504 200 506 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.099N P=0.185N P=0.112N | P=0.418 P=0.353 P=0.454 |
|INCIDENTAL TUMOR | P=0.539 P=0.453 P=0.576N | P=0.496 P=0.363 P=0.561 |
|LOGISTIC REGRESSION | P=0.485 P=0.465 P=0.542 | P=0.474 P=0.363 P=0.477 |
|COCHRAN-ARMITAGE | P=0.377N | P=0.460 |
|FISHER EXACT | P=0.500N P=0.418N | P=0.339 P=0.500 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05023 TEST: 01 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- PENTAERYTHRITOL TETRANITRATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 2.5% 5.0% | CONTROL 0.62% 1.25% |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 49/50 (98%) 49/50 (98%) 50/50 (100%) | 46/50 (92%) 47/50 (94%) 50/50 (100%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 92.0% 94.0% 100.0% |
|TERMINAL (d) | 22/22 (100%) 29/29 (100%) 29/29 (100%) | 29/33 (88%) 30/33 (91%) 31/31 (100%) |
|FIRST INCIDENCE (DAYS) | 479 501 560 | 441 200 441 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.056N P=0.084N P=0.064N | P=0.188 P=0.490 P=0.212 |
|INCIDENTAL TUMOR | P=0.718 P=0.718 (e) | P=0.053 P=0.500 P=0.070 |
|LOGISTIC REGRESSION | P=0.718 P=0.718 (e) | P=0.053 P=0.500 P=0.070 |
|COCHRAN-ARMITAGE | P=0.331 | P=0.048 * |
|FISHER EXACT | P=0.753N P=0.500 | P=0.500 P=0.059 |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
--multipart-boundary
Content-type: text/plain
Range: bytes 165339-165339/165339
--multipart-boundary--