TR 365 Rat Pathology Tables
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 Facility: TSI Mason Research Chemical CAS #: 78-11-5 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 2| 5| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| | 7| 7| 7| 7| 3| 7| 7| 7| 9| 7| 8| 8| 7| 2| 7| 8| 9| 7| 8| 0| 8| 8| 9| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite | 1 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + M + +| Parasite | 1| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + M A + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | | Congestion | 2 | Developmental Malformation | X X | Eosinophilic Focus | X | Fatty Change, Diffuse | 1 2 2 2 | Fatty Change, Focal | 1 1 1 | Focal Cellular Change | | Hepatodiaphragmatic Nodule | X | Hyperplasia | | Inflammation, Chronic, Focal | 1 | Inflammation, Chronic Active | 1 | Inflammation, Granulomatous | 1 | Mixed Cell Focus | X X | Necrosis | | Bile Duct, Hyperplasia | 2 2 | __________________________________________________________________________| Mesentery | + + | Fat, Hemorrhage | | Fat, Necrosis | 2 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | | __________________________________________________________________________| Pharynx | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Hyperkeratosis | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | | Mineralization | 1 | Necrosis | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 2| 5| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| | 7| 7| 7| 7| 3| 7| 7| 7| 9| 7| 8| 8| 7| 2| 7| 8| 9| 7| 8| 0| 8| 8| 9| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 1 2 2 1 2 2 | Artery, Necrosis, Fibrinoid | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration | 2 | Hyperplasia | 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + M + + M + M + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Hyperplasia | 2 | Pars Distalis, Angiectasis | 4 2 2 1 2 2 1 2 2 3 2 2 1 1 2 2| Pars Distalis, Cyst | | Pars Distalis, Cyst, Multiple | X | Pars Distalis, Hyperplasia | 2 2 3 2 2 2 2 1 3| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 2 2 | Follicular Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + M + + + + + M M M + + + + + M + + + + + +| Hyperplasia | 2 | Inflammation, Chronic Active | 2 | Necrosis | 2 3 2 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X X | __________________________________________________________________________| Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Angiectasis | 1 | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 2| 5| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| | 7| 7| 7| 7| 3| 7| 7| 7| 9| 7| 8| 8| 7| 2| 7| 8| 9| 7| 8| 0| 8| 8| 9| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Mediastinal, Pigmentation | 2 | Pancreatic, Pigmentation | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + M M + +| Angiectasis | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Hemorrhage | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +| Depletion Lymphoid | | Fibrosis | | Hematopoietic Cell Proliferation | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2| Hemorrhage | | Hyperplasia, Reticulum Cell | | Necrosis | 2 | Pigmentation | 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 | __________________________________________________________________________| Thymus | + + + + + M + + + + + + M + + + + + + + + + + + +| Epithelial Cell, Hyperplasia | 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| Galactocele | X X X X X X X X X X X X X X X X X X X| Acinus, Hyperplasia | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + M + + + + + + + + + + + + +| Acanthosis | 3 | Hemorrhage | 2 | Hyperkeratosis | 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 2 | Edema | | Hemorrhage | 1 1 | Infiltration Cellular, Histiocyte | 1 | Alveolar Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 2| 5| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3| | 7| 7| 7| 7| 3| 7| 7| 7| 9| 7| 8| 8| 7| 2| 7| 8| 9| 7| 8| 0| 8| 8| 9| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | Acanthosis | | Hyperkeratosis | | __________________________________________________________________________| Eye | + + + + | __________________________________________________________________________| Harderian Gland | + + | __________________________________________________________________________| Zymbal's Gland | + + + M + + + M + + + + + M + + M + + + + M M + +| Hyperplasia | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 2 2 1 2 1 2 2 2 1 3 2 3 1 1 1 3 2 1 1 1 1 1 2 2 1| Cortex, Mineralization | 1 1 | Renal Tubule, Pigmentation | 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 4| 2| 4| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 3| 3| 3| 4| 6| | | 8| 8| 8| 0| 4| 8| 8| 4| 8| 1| 8| 9| 9| 6| 0| 8| 8| 8| 9| 2| 9| 8| 8| 7| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + A + + + + + A + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + A + + + + + A + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + A + + + + + A + + + + + + + + + +| 48 | Parasite | 1 2 2 2| 5 1.6| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + A + + + + + A + + + + + + + + + +| 46 | Parasite | | 1 1.0| __________________________________________________________________________|____________| Intestine Small | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + A + + + + + A + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + + + + + A + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 1 1.0| Basophilic Focus | X X X X X X X X X X X X X X X X X X X| 41 | Clear Cell Focus | X | 1 | Congestion | | 1 2.0| Developmental Malformation | | 2 | Eosinophilic Focus | | 1 | Fatty Change, Diffuse | 3 2 | 6 2.0| Fatty Change, Focal | 1 | 4 1.0| Focal Cellular Change | X X | 2 | Hepatodiaphragmatic Nodule | X | 2 | Hyperplasia | 2 | 1 2.0| Inflammation, Chronic, Focal | | 1 1.0| Inflammation, Chronic Active | | 1 1.0| Inflammation, Granulomatous | | 1 1.0| Mixed Cell Focus | X | 3 | Necrosis | 1 | 1 1.0| Bile Duct, Hyperplasia | 2 1 | 4 1.8| __________________________________________________________________________|____________| Mesentery | + | 3 | Fat, Hemorrhage | 2 | 1 2.0| Fat, Necrosis | | 2 2.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 1 | 1 1.0| __________________________________________________________________________|____________| Pharynx | + | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 2 1| 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 4| 2| 4| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 3| 3| 3| 4| 6| | | 8| 8| 8| 0| 4| 8| 8| 4| 8| 1| 8| 9| 9| 6| 0| 8| 8| 8| 9| 2| 9| 8| 8| 7| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Hyperkeratosis | 2 1 | 2 1.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Lymphocyte | 2 | 1 2.0| Mineralization | 1 | 2 1.0| Necrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 28 1.9| Artery, Necrosis, Fibrinoid | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | Degeneration | | 1 2.0| Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | Hyperplasia | 1 1 1 1| 6 1.2| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + M M + + + + + + + + + + + + + + +| 43 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | | 1 2.0| Hyperplasia | 2 | 2 2.0| Pars Distalis, Angiectasis | 2 2 2 2 2 3 2 2 3 2 2 2| 28 2.0| Pars Distalis, Cyst | X X | 2 | Pars Distalis, Cyst, Multiple | | 1 | Pars Distalis, Hyperplasia | 3 2 2 2 2 2 | 15 2.1| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 1| 7 1.3| Follicular Cell, Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + M + M + + M + + + + + + M + + + M + M + +| 39 | Hyperplasia | 2 1| 3 1.7| Inflammation, Chronic Active | | 1 2.0| Necrosis | 2 3 2 | 7 2.4| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 4| 2| 4| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 3| 3| 3| 4| 6| | | 8| 8| 8| 0| 4| 8| 8| 4| 8| 1| 8| 9| 9| 6| 0| 8| 8| 8| 9| 2| 9| 8| 8| 7| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X | 4 | __________________________________________________________________________|____________| Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Vagina | + + | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mediastinal, Angiectasis | | 1 1.0| Mediastinal, Pigmentation | 1 | 2 1.5| Pancreatic, Pigmentation | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Angiectasis | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | | 1 2.0| Hemorrhage | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Depletion Lymphoid | 1 | 1 1.0| Fibrosis | 1 | 1 1.0| Hematopoietic Cell Proliferation | 2 1 1 2 3 1 2 2 2 2 2 2 1 2 2 2 2| 33 1.9| Hemorrhage | 3 | 1 3.0| Hyperplasia, Reticulum Cell | 3 | 1 3.0| Necrosis | | 1 2.0| Pigmentation | 2 2 2 2 1 2 2 2 2 2 2 2 2| 33 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + M + + + + + + + + + M + + + + + +| 46 | Epithelial Cell, Hyperplasia | | 2 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + M + + + M + + + + + + M + + + + + + + + +| 46 | Galactocele | X X X X X X X X X X X X X X X X| 35 | Acinus, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | | 1 3.0| Hemorrhage | | 1 2.0| Hyperkeratosis | 4 | 2 2.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 4| 2| 4| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 3| 3| 3| 4| 6| | | 8| 8| 8| 0| 4| 8| 8| 4| 8| 1| 8| 9| 9| 6| 0| 8| 8| 8| 9| 2| 9| 8| 8| 7| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 3 | 1 3.0| __________________________________________________________________________|____________| Spinal Cord | +| 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 1 2 | 4 1.8| Edema | 1 | 1 1.0| Hemorrhage | 1 1 1 2 | 6 1.2| Infiltration Cellular, Histiocyte | 1 1 1 1 | 5 1.0| Alveolar Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + + | 2 | Acanthosis | 3 | 1 3.0| Hyperkeratosis | 3 4 | 2 3.5| __________________________________________________________________________|____________| Eye | + +| 6 | __________________________________________________________________________|____________| Harderian Gland | + | 3 | __________________________________________________________________________|____________| Zymbal's Gland | + + + + + + M M + M + + M + + + M + M + + + M M +| 36 | Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nephropathy | 2 2 2 1 2 2 2 1 2 2 1 2 2 2 2 2 2 1 1 1 2| 46 1.7| Cortex, Mineralization | 1 1 | 4 1.0| Renal Tubule, Pigmentation | | 1 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8| | 7| 7| 7| 8| 9| 7| 7| 7| 2| 5| 7| 7| 7| 7| 5| 7| 7| 7| 3| 9| 7| 7| 7| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.62% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + +| __________________________________________________________________________| Intestine Small | + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + +| Lymphoid Nodule, Hyperplasia | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X | Eosinophilic Focus | X | Fatty Change, Diffuse | 2 3 | Fatty Change, Focal | 1 2 1 2| Hepatodiaphragmatic Nodule | X X X | Hyperplasia | 2 1 | Mixed Cell Focus | X | Necrosis | | Bile Duct, Hyperplasia | 2 | __________________________________________________________________________| Mesentery | + + | Artery, Inflammation, Chronic Active | 1 | Artery, Pigmentation | 2 | Artery, Thrombosis | 3 | Fat, Necrosis | 3 | Fat, Pigmentation | | __________________________________________________________________________| Pancreas | + + + + + + + +| Artery, Inflammation, Chronic Active | 2 | __________________________________________________________________________| Salivary Glands | + + + + +| Inflammation, Acute | | __________________________________________________________________________| Stomach | + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + +| Acanthosis | | Hyperkeratosis | | Inflammation, Chronic Active | | Necrosis | | __________________________________________________________________________| Stomach, Glandular | + + + +| Necrosis | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + +| Cardiomyopathy | 2 2 | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8| | 7| 7| 7| 8| 9| 7| 7| 7| 2| 5| 7| 7| 7| 7| 5| 7| 7| 7| 3| 9| 7| 7| 7| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.62% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + +| Pars Distalis, Angiectasis | 3 3 3 2 3 2| Pars Distalis, Cyst | X X | Pars Distalis, Hyperplasia | 2 | Pars Intermedia, Hyperplasia | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| C-Cell, Hyperplasia | 2 1 1 2 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M + + + M + +| Hyperplasia | 2 | Inflammation, Acute | | Inflammation, Chronic Active | 2 | Necrosis | 3 | __________________________________________________________________________| Ovary | + + + + +| Cyst | X | __________________________________________________________________________| Oviduct | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Pigmentation | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + +| __________________________________________________________________________| Lymph Node | + + + + + +| Mediastinal, Angiectasis | | Mediastinal, Infiltration Cellular, | | Histiocyte | 2 | Pancreatic, Infiltration Cellular, | | Histiocyte | 2 | Renal, Angiectasis | 2 | Renal, Infiltration Cellular, | | Histiocyte | 2 | __________________________________________________________________________| Lymph Node, Mandibular | M M + + M| Degeneration, Cystic | 2 | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8| | 7| 7| 7| 8| 9| 7| 7| 7| 2| 5| 7| 7| 7| 7| 5| 7| 7| 7| 3| 9| 7| 7| 7| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.62% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Infiltration Cellular, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + +| Infiltration Cellular, Histiocyte | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + +| Depletion Lymphoid | | Hematopoietic Cell Proliferation | 2 2 2 2 2 | Necrosis | | Pigmentation | 2 3 3 | __________________________________________________________________________| Thymus | + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + +| Galactocele | X X X X X X | Acinus, Hyperplasia | 2 | __________________________________________________________________________| Skin | + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + +| Hydrocephalus | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | Fibrosis | 3 | Hemorrhage | 1 | Inflammation, Chronic Active | 2 | Alveolar Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Nose | + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + +| __________________________________________________________________________| Eye | + + + +| Lens, Cataract | | Retina, Atrophy | 2 2 | __________________________________________________________________________| Harderian Gland | + + | __________________________________________________________________________| Zymbal's Gland | M M M M + M + + + + + + M + + + + + + + M + + M +| Cyst | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8| | 7| 7| 7| 8| 9| 7| 7| 7| 2| 5| 7| 7| 7| 7| 5| 7| 7| 7| 3| 9| 7| 7| 7| 5| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0.62% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 2 2 2 1 2 2 2 2 2 2 1 2 2 1 1 2 2 2 | Cortex, Mineralization | | Cortex, Necrosis | 2 | Papilla, Mineralization | | Pelvis, Mineralization | 1 | Renal Tubule, Hyperplasia | | Renal Tubule, Pigmentation | 2| Transitional Epithelium, Hyperplasia | | __________________________________________________________________________| Urinary Bladder | + + + +| Hemorrhage | | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 2| 7| 7| 5| 5| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 7| 4| 0| 3| 3| 8| 4| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| | | 7| 7| 3| 1| 0| 7| 7| 5| 7| 3| 7| 7| 7| 7| 8| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 0.62% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + | 11 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + M + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + +| 14 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + | 11 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + +| 13 | Lymphoid Nodule, Hyperplasia | 1 | 2 1.5| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 2 | 2 1.5| Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 41 | Clear Cell Focus | X | 2 | Eosinophilic Focus | X X | 3 | Fatty Change, Diffuse | 3 3 2 | 5 2.6| Fatty Change, Focal | | 4 1.5| Hepatodiaphragmatic Nodule | X X X X | 7 | Hyperplasia | | 2 1.5| Mixed Cell Focus | | 1 | Necrosis | 3 1 | 2 2.0| Bile Duct, Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Mesentery | + + | 4 | Artery, Inflammation, Chronic Active | | 1 1.0| Artery, Pigmentation | | 1 2.0| Artery, Thrombosis | | 1 3.0| Fat, Necrosis | 3 | 2 3.0| Fat, Pigmentation | 3 | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + | 17 | Artery, Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + | 13 | Inflammation, Acute | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach | + + + + + + + | 11 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + | 11 | Acanthosis | 3 | 1 3.0| Hyperkeratosis | 3 | 1 3.0| Inflammation, Chronic Active | 2 1 | 2 1.5| Necrosis | 2 2 | 2 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + | 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 2| 7| 7| 5| 5| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 7| 4| 0| 3| 3| 8| 4| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| | | 7| 7| 3| 1| 0| 7| 7| 5| 7| 3| 7| 7| 7| 7| 8| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 0.62% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Necrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + | 10 | Cardiomyopathy | 2 | 3 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + | 12 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + | 12 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + | 12 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 17 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + M M + + + + M + + + + + + + + +| 36 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + +| 30 | Pars Distalis, Angiectasis | 2 2 2 3 3 2 2 2 1 3 2 2| 18 2.3| Pars Distalis, Cyst | X | 3 | Pars Distalis, Hyperplasia | 2 2 | 3 2.0| Pars Intermedia, Hyperplasia | 2 | 2 1.5| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | C-Cell, Hyperplasia | 2 1 1 1 | 9 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M + + M M + + + + | 12 | Hyperplasia | | 1 2.0| Inflammation, Acute | 2 | 1 2.0| Inflammation, Chronic Active | 1 | 2 1.5| Necrosis | | 1 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 15 | Cyst | X X X | 4 | __________________________________________________________________________|____________| Oviduct | + | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + +| 48 | Pigmentation | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + | 17 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 2| 7| 7| 5| 5| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 7| 4| 0| 3| 3| 8| 4| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| | | 7| 7| 3| 1| 0| 7| 7| 5| 7| 3| 7| 7| 7| 7| 8| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 0.62% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Mediastinal, Angiectasis | 3 | 1 3.0| Mediastinal, Infiltration Cellular, | | | Histiocyte | | 1 2.0| Pancreatic, Infiltration Cellular, | | | Histiocyte | 2 | 2 2.0| Renal, Angiectasis | | 1 2.0| Renal, Infiltration Cellular, | | | Histiocyte | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + | 11 | Degeneration, Cystic | | 1 2.0| Infiltration Cellular, Plasma Cell | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + | 12 | Infiltration Cellular, Histiocyte | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + | 26 | Depletion Lymphoid | 2 | 1 2.0| Hematopoietic Cell Proliferation | 1 3 3 2 2 2 2 | 12 2.1| Necrosis | 3 | 1 3.0| Pigmentation | 2 3 2 3 2 2 2 | 10 2.4| __________________________________________________________________________|____________| Thymus | + + + + + M | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + + + + + + + + + + + + + + + + | 34 | Galactocele | X X X X X X X X X | 15 | Acinus, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + +| 15 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + | 10 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + | 10 | Hydrocephalus | 3 | 1 3.0| __________________________________________________________________________|____________| Spinal Cord | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 2 2 2 3 2 3 2 2 2 2 3 2 2 2| 30 2.1| Fibrosis | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 2| 7| 7| 5| 5| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 7| 4| 0| 3| 3| 8| 4| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| | | 7| 7| 3| 1| 0| 7| 7| 5| 7| 3| 7| 7| 7| 7| 8| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 0.62% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Hemorrhage | 2 1 | 3 1.3| Inflammation, Chronic Active | | 1 2.0| Alveolar Epithelium, Hyperplasia | 2| 2 2.0| __________________________________________________________________________|____________| Nose | + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + +| 39 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 2 | __________________________________________________________________________|____________| Eye | + + + | 7 | Lens, Cataract | 2 | 1 2.0| Retina, Atrophy | | 2 2.0| __________________________________________________________________________|____________| Harderian Gland | + | 3 | __________________________________________________________________________|____________| Zymbal's Gland | + + + + + M + + + + + + M M M M + + + + + + + + +| 37 | Cyst | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nephropathy | 2 2 4 3 1 2 1 2 2 2 1 1 1 3 1 2 1 2 1 1 2| 39 1.8| Cortex, Mineralization | 1 | 1 1.0| Cortex, Necrosis | | 1 2.0| Papilla, Mineralization | 1 | 1 1.0| Pelvis, Mineralization | | 1 1.0| Renal Tubule, Hyperplasia | 2| 1 2.0| Renal Tubule, Pigmentation | | 1 2.0| Transitional Epithelium, Hyperplasia | 1 2 | 2 1.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + | 10 | Hemorrhage | 2 | 1 2.0| Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 4| 3| 3| 3| 0| 6| 3| 3| 0| 8| 4| | 5| 5| 5| 5| 4| 5| 5| 5| 4| 8| 5| 5| 5| 5| 1| 5| 5| 5| 8| 2| 6| 5| 9| 9| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1.25% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + M + + + + M + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite | 2 1 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + M + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoid Nodule, Hyperplasia | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoid Nodule, Hyperplasia | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X | Congestion | 2 | Developmental Malformation | X X | Eosinophilic Focus | X | Fatty Change, Diffuse | 2 2 | Fatty Change, Focal | 1 2 1 1 2 | Focal Cellular Change | X X | Hepatodiaphragmatic Nodule | X | Inflammation, Chronic Active | | Mixed Cell Focus | X X X | Necrosis | 2 | Bile Duct, Hyperplasia | 2 2 | __________________________________________________________________________| Mesentery | + +| Fat, Hemorrhage | 3 | Fat, Necrosis | 1| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | | __________________________________________________________________________| Pharynx | | Palate, Epithelium, Hyperplasia | | __________________________________________________________________________| Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Hyperkeratosis | 2 | Necrosis | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 1 | Mineralization | 1 | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 4| 3| 3| 3| 0| 6| 3| 3| 0| 8| 4| | 5| 5| 5| 5| 4| 5| 5| 5| 4| 8| 5| 5| 5| 5| 1| 5| 5| 5| 8| 2| 6| 5| 9| 9| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1.25% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 2 2 1 2 | Artery, Necrosis, Fibrinoid | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | Necrosis | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 2 3 | Necrosis | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + M + + + M + M + + + + + + + + M + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Pars Distalis, Angiectasis | 2 2 1 2 2 2 1 2 2 2 2 1 3| Pars Distalis, Cyst | | Pars Distalis, Hemorrhage | | Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 2 | Pars Distalis, Pigmentation | 1 | Pars Nervosa, Cyst, Multiple | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | C-Cell, Hyperplasia | 1 1 | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + M + + + + + + + + + M + + M + + + + + M M| Dilatation | 3 | Hyperplasia | 2 | Inflammation, Chronic Active | 1 | Necrosis | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X X | __________________________________________________________________________| Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 3 | Endometrium, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 4| 3| 3| 3| 0| 6| 3| 3| 0| 8| 4| | 5| 5| 5| 5| 4| 5| 5| 5| 4| 8| 5| 5| 5| 5| 1| 5| 5| 5| 8| 2| 6| 5| 9| 9| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1.25% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + M + + + + + + + + + +| Mediastinal, Congestion | | Mediastinal, Hemorrhage | | Mediastinal, Pigmentation | | Renal, Angiectasis | 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + M + + + + + M + + + + + + + + + +| Infiltration Cellular, Plasma Cell | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + M + + + + +| Congestion | 2 | Necrosis | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2 2 2 1 2 2 2 2 2| Necrosis | | Pigmentation | 2 2 2 2 2 2 3 2 2 2 2 2 3 2 2 2 2 3 2 2 2 2 2| __________________________________________________________________________| Thymus | + + + + + + + + M + + + + + + + + + + + + M + + +| Depletion Lymphoid | 2 | Epithelial Cell, Hyperplasia | 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + M| Galactocele | X X X X X X X X X X X X X X X | Acinus, Hyperplasia | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Mineralization | 1 | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Edema | 3 | Hemorrhage | 1 1 1 1 | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 4| 3| 3| 3| 0| 6| 3| 3| 0| 8| 4| | 5| 5| 5| 5| 4| 5| 5| 5| 4| 8| 5| 5| 5| 5| 1| 5| 5| 5| 8| 2| 6| 5| 9| 9| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1.25% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Infiltration Cellular, Histiocyte | 1 1 2 1 1 | Mineralization | 2 | Necrosis | | Goblet Cell, Hypertrophy | 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + | Cornea, Inflammation, Chronic Active | 1 | __________________________________________________________________________| Harderian Gland | + + | Abscess | 3 | Pigmentation | 3 | __________________________________________________________________________| Zymbal's Gland | + + M + + + + + + + + + + + + + + M M + + + M M M| Cyst | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Nephropathy | 2 1 1 3 2 2 3 2 2 1 2 2 1 1 2 2 3 2 3 1 2 2 2 2 2| Cortex, Mineralization | 1 1 1 1 1 | Papilla, Mineralization | 1 1 | Pelvis, Mineralization | | Renal Tubule, Hyperplasia | | Renal Tubule, Pigmentation | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8| | | 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 1.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 | Hyperkeratosis | 1 | 1 1.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + A M + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite | 1 1 1 1 1 | 7 1.1| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 | Lymphoid Nodule, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 | Lymphoid Nodule, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 3 1.7| Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 43 | Clear Cell Focus | | 1 | Congestion | | 1 2.0| Developmental Malformation | X | 3 | Eosinophilic Focus | | 1 | Fatty Change, Diffuse | 2 2 | 4 2.0| Fatty Change, Focal | 1 1 2 | 8 1.4| Focal Cellular Change | X| 3 | Hepatodiaphragmatic Nodule | X X | 3 | Inflammation, Chronic Active | 2 | 1 2.0| Mixed Cell Focus | | 3 | Necrosis | | 1 2.0| Bile Duct, Hyperplasia | | 2 2.0| __________________________________________________________________________|____________| Mesentery | + + | 4 | Fat, Hemorrhage | | 1 3.0| Fat, Necrosis | 4 3 | 3 2.7| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | Acinus, Atrophy | 1 | 1 1.0| __________________________________________________________________________|____________| Pharynx | + | 1 | Palate, Epithelium, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + M + + + + + + + + + + + M + +| 48 | Acanthosis | 1 1 1 1 | 4 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8| | | 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 1.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Hyperkeratosis | 2 1 2 1 1 2 | 7 1.6| Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 4 1.3| Mineralization | 1 | 2 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2| 23 2.0| Artery, Necrosis, Fibrinoid | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | Hyperplasia | 2 | 2 1.5| Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | Hyperplasia | 1 1 1 | 7 1.4| Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | Hyperplasia, Focal | 1 | 1 1.0| Pars Distalis, Angiectasis | 2 2 1 2 2 3 2 1 2 1 2 1 3| 26 1.8| Pars Distalis, Cyst | X X | 2 | Pars Distalis, Hemorrhage | 2 | 1 2.0| Pars Distalis, Hyperplasia | 1 2 2 2 1 2 2 2 | 16 1.9| Pars Distalis, Pigmentation | 1 | 2 1.0| Pars Nervosa, Cyst, Multiple | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 2 | 1 2.0| C-Cell, Hyperplasia | 2 1 1 | 5 1.2| Follicular Cell, Hyperplasia | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + M M + + M + M + + + + + +| 41 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8| | | 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 1.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Dilatation | | 1 3.0| Hyperplasia | 2 | 2 2.0| Inflammation, Chronic Active | 1 | 2 1.0| Necrosis | 3 2 | 3 2.3| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 3 | __________________________________________________________________________|____________| Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 2 | 2 2.5| Endometrium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Vagina | + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mediastinal, Congestion | 2 | 1 2.0| Mediastinal, Hemorrhage | 2 | 1 2.0| Mediastinal, Pigmentation | 2 2 2 | 3 2.0| Renal, Angiectasis | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 | Infiltration Cellular, Plasma Cell | 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Congestion | 2 | 2 2.0| Necrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 1 2.0| Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 1| 41 1.9| Necrosis | 2 | 1 2.0| Pigmentation | 3 3 2 2 2 2 2 2 2 2 3 2 2 2 2| 38 2.2| __________________________________________________________________________|____________| Thymus | + M + + + + + + + + + + + + + + M + + + M + + M +| 44 | Depletion Lymphoid | | 1 2.0| Epithelial Cell, Hyperplasia | | 2 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Galactocele | X X X X X X X X X X X X X X X X X| 32 | Acinus, Hyperplasia | 2 2 2 | 3 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8| | | 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 1.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 2.0| Mineralization | | 1 1.0| __________________________________________________________________________|____________| Spinal Cord | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 2 | 2 2.0| Edema | 2 | 2 2.5| Hemorrhage | 1 | 5 1.0| Infiltration Cellular, Histiocyte | 1 2 | 7 1.3| Mineralization | | 1 2.0| Necrosis | 1 | 1 1.0| Goblet Cell, Hypertrophy | | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 5 | Cornea, Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Harderian Gland | + | 3 | Abscess | | 1 3.0| Pigmentation | | 1 3.0| __________________________________________________________________________|____________| Zymbal's Gland | + M + M M M + + + + M + M + + M + + + M M + + + +| 35 | Cyst | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 | 1 2.0| Nephropathy | 2 2 2 1 2 2 3 1 2 2 2 1 2 2 2 1 1 1 2 2 2 2 2 3| 49 1.9| Cortex, Mineralization | 1 1 | 7 1.0| Papilla, Mineralization | 1 1 | 4 1.0| Pelvis, Mineralization | 1| 1 1.0| Renal Tubule, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8| | | 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 1.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Renal Tubule, Pigmentation | 1 1 | 2 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4| DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7| | 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +| Parasite | 1 1 2 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +| Parasite | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 1 | Basophilic Focus | X X X X X X X X X X X X X | Clear Cell Focus | X | Congestion | | Degeneration, Cystic | 1 1 | Eosinophilic Focus | | Fatty Change, Diffuse | 2 | Fatty Change, Focal | 1 2 1 | Focal Cellular Change | X | Hepatodiaphragmatic Nodule | X X X | Hyperplasia, Focal | | Hyperplasia | 2 2 | Mixed Cell Focus | X X | Necrosis | 2 | Vacuolization Cytoplasmic | | Bile Duct, Hyperplasia | 1 2 2 2 2 2 2 1 2 1 2 2 2 3 2 3 1 2 2 2 1 2 | Oval Cell, Hyperplasia | | __________________________________________________________________________| Mesentery | + + | Fat, Mineralization | | Fat, Necrosis | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | | Acinus, Hyperplasia | 1 | Artery, Mineralization | 2 | Artery, Necrosis, Fibrinoid | 2 1 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 1 | Edema | | Fibrosis | 2 | Hyperkeratosis | 1 3 1 | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4| DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7| | 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Inflammation, Chronic Active | 2 | Necrosis | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A +| Mineralization | 3 | Necrosis | | __________________________________________________________________________| Tongue | | Hyperkeratosis | | __________________________________________________________________________| Tooth | | Gingiva, Inflammation, Chronic | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 1 2 2 2 2 2 2 2 2 2 2 2 1 2 2| Inflammation, Chronic Active | | Artery, Mineralization | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 1 1 2 1 2 1 1 1 2 1 1 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M M + + + + M| Hyperplasia | 1 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2 2 2 3 2 | Pars Distalis, Cyst | X | Pars Distalis, Hyperplasia, Focal | 2 | Pars Distalis, Hyperplasia | 1 2 2 1 2 2 | Pars Intermedia, Hyperplasia | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 1 | Follicular Cell, Hyperplasia | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | + + +| __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + M + +| Mineralization | 1 2 1| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + M + + + + + + + + +| Dilatation | | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4| DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7| | 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Inflammation, Chronic Active | 1 | Necrosis | 1 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +| Inflammation, Chronic Active | 2 2 2 2 2 | Pigmentation | | Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 1 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 2 1 1 1 1 1 2 1 1 1 1 1 1 2 2 | Seminiferous Tubule, Atrophy | 2 2 2 1 1 1 2 2 3 2 2 1 2 2 2 2 2 2 3 2 2 | Seminiferous Tubule, Mineralization | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Congestion | 1 | Lumbar, Infiltration Cellular, | | Plasma Cell | 2 | Mediastinal, Angiectasis | 2 2 | Mediastinal, Pigmentation | 2 1 | Pancreatic, Infiltration Cellular, | | Plasma Cell | | Renal, Pigmentation | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Erythrophagocytosis | | Hemorrhage | 1 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | | Hemorrhage | 2 | Infiltration Cellular, Plasma Cell | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Depletion Lymphoid | 2 | Fibrosis | 3 | Hematopoietic Cell Proliferation | 1 1 1 1 2 3 1 1 1 1 2 2 2| Necrosis | 2 | Pigmentation | 2 2 2 1 | __________________________________________________________________________| Thymus | + + + M + + + M + + M M + + + + M + + + + + + +| Depletion Lymphoid | 2 | Epithelial Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4| DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7| | 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Mammary Gland | + + M + + M M + + + + M + M + + M + M M + + + M +| Galactocele | X X | Acinus, Hyperplasia | | __________________________________________________________________________| Skin | + + + + + + + + + + M + + + + + + + + + + + + + +| Acanthosis | | Hyperkeratosis | 4 | Necrosis | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Atelectasis | | Congestion | 1 2 3 | Edema | 2 | Embolus Tumor | | Fibrosis | | Hemorrhage | 1 1 1 | Infiltration Cellular, Histiocyte | 1 | Inflammation, Acute | | Inflammation, Chronic Active | | Alveolar Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + M +| Inflammation, Acute | 2 | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + | Cornea, Inflammation, Acute | 1 | Lens, Cataract | 2 | __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X X | Inflammation, Granulomatous | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Nephropathy | 3 3 3 3 3 3 3 3 3 1 3 4 2 2 3 3 3 2 2 2 3 3 3 1 1| _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4| DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7| | 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Cortex, Mineralization | 1 2 | Papilla, Mineralization | 1 1 | Renal Tubule, Necrosis | | Renal Tubule, Pigmentation | 1 | Transitional Epithelium, Hyperplasia | 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + M + M + + + + + + + + + +| Calculus Micro Observation Only | | Artery, Necrosis, Fibrinoid | 1 | _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7| | | 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + M + + + + + + + + M + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large | + + + + M + + + + + + + + + + + + + + A + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + M + + + + + + + + + A + + + + A + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + M + + + + + + + + + + + + + + A + + + + +| 47 | Parasite | 2 1 1 | 6 1.3| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + M + + + + + + + + + A + + + + A + + + + +| 46 | Parasite | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Small | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + A + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + M + + + M + + + A + + + + + + A + + + + +| 45 | __________________________________________________________________________|____________| Liver | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 2 1| 5 1.4| Basophilic Focus | X X X X X X X X X X X X| 25 | Clear Cell Focus | X | 2 | Congestion | 2 | 1 2.0| Degeneration, Cystic | 1 | 3 1.0| Eosinophilic Focus | X| 1 | Fatty Change, Diffuse | 2 1 | 3 1.7| Fatty Change, Focal | 1 2 1 1 | 7 1.3| Focal Cellular Change | X | 2 | Hepatodiaphragmatic Nodule | X | 4 | Hyperplasia, Focal | 2 | 1 2.0| Hyperplasia | 2 | 3 2.0| Mixed Cell Focus | X X | 4 | Necrosis | 1 2 | 3 1.7| Vacuolization Cytoplasmic | 2 | 1 2.0| Bile Duct, Hyperplasia | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1| 39 1.9| Oval Cell, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + + | 5 | Fat, Mineralization | 1 2 | 2 1.5| Fat, Necrosis | 3 3 | 2 3.0| __________________________________________________________________________|____________| Pancreas | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Atrophy | 1 | 1 1.0| Acinus, Hyperplasia | 2 2 | 3 1.7| Artery, Mineralization | | 1 2.0| Artery, Necrosis, Fibrinoid | 2 | 4 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + M + + + + + + + + + + + M + + + + + + + +| 48 | __________________________________________________________________________|____________| Stomach | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7| | | 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 2 | 3 1.7| Edema | 2 | 1 2.0| Fibrosis | | 1 2.0| Hyperkeratosis | 1 | 4 1.5| Inflammation, Chronic Active | 3 | 2 2.5| Necrosis | 2 | 2 2.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 | Mineralization | | 1 3.0| Necrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Tongue | + + | 2 | Hyperkeratosis | 2 | 1 2.0| __________________________________________________________________________|____________| Tooth | + | 1 | Gingiva, Inflammation, Chronic | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Cardiomyopathy | 2 1 1 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 1| 37 1.8| Inflammation, Chronic Active | 1 | 1 1.0| Artery, Mineralization | 1 | 2 1.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 1 1 1 1 1 2 1 1 3 2 1| 25 1.3| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + + + + M M M + M + + M + + + M +| 40 | Hyperplasia | | 2 1.5| __________________________________________________________________________|____________| Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Angiectasis | 1 2 2 1 2 2 2 | 12 1.9| Pars Distalis, Cyst | X | 2 | Pars Distalis, Hyperplasia, Focal | | 1 2.0| Pars Distalis, Hyperplasia | 2 2 2 1 | 10 1.7| Pars Intermedia, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Hyperplasia | 1 | 4 1.3| Follicular Cell, Hyperplasia | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7| | | 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | + + + + + + | 9 | __________________________________________________________________________|____________| Epididymis | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 | Mineralization | 1 | 4 1.3| __________________________________________________________________________|____________| Preputial Gland | + + + + M M + + + + + + + + + + + + + + + + + + +| 46 | Dilatation | 3 | 1 3.0| Inflammation, Chronic Active | 2 | 2 1.5| Necrosis | 2 1 3 2 2 2 | 7 1.9| __________________________________________________________________________|____________| Prostate | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic Active | 2 3 1 3 2 1 2 | 12 2.0| Pigmentation | 2 | 1 2.0| Epithelium, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 1 | 3 1.3| __________________________________________________________________________|____________| Testes | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Interstitial Cell, Hyperplasia | 1 2 2 2 1 1 1 1 2 1 1 1 2 | 28 1.3| Seminiferous Tubule, Atrophy | 2 2 2 2 1 2 1 1 1 2 1 1 1 2 2 2 2 2 2 2 2 2| 43 1.8| Seminiferous Tubule, Mineralization | 1 1 1 1 | 4 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Lymph Node | + + + + M + + + + + + + + + + + + + + + + + + +| 48 | Lumbar, Congestion | | 1 1.0| Lumbar, Infiltration Cellular, | | | Plasma Cell | | 1 2.0| Mediastinal, Angiectasis | | 2 2.0| Mediastinal, Pigmentation | 2 | 3 1.7| Pancreatic, Infiltration Cellular, | | | Plasma Cell | 1 | 1 1.0| Renal, Pigmentation | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + M + + + + + + + + + + + M + + + + + + +| 46 | Cyst | X X X | 4 | Erythrophagocytosis | 2 | 1 2.0| Hemorrhage | 2 | 2 1.5| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + A + + + +| 47 | Degeneration, Cystic | 2 | 1 2.0| Hemorrhage | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7| | | 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Infiltration Cellular, Plasma Cell | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 | Congestion | 2 | 2 2.0| Depletion Lymphoid | | 1 2.0| Fibrosis | | 1 3.0| Hematopoietic Cell Proliferation | 1 2 2 2 1 1 2 1 2 2 2 2 1 | 26 1.5| Necrosis | | 1 2.0| Pigmentation | 1 2 | 6 1.7| __________________________________________________________________________|____________| Thymus | + + + + M + + + M + + + + M M + + + A M + M + +| 36 | Depletion Lymphoid | 2 2 | 3 2.0| Epithelial Cell, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + M + + + M + + + + + + + + + + M + + + + +| 37 | Galactocele | X X | 4 | Acinus, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 | Acanthosis | 2 2 2 | 3 2.0| Hyperkeratosis | 4 4 3| 4 3.8| Necrosis | 3 | 2 2.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | 2 2 | 3 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Atelectasis | 2 | 1 2.0| Congestion | 2 2 3 2 2 2 2| 10 2.1| Edema | 1 2 | 3 1.7| Embolus Tumor | X | 1 | Fibrosis | 2 | 1 2.0| Hemorrhage | 1 2 1 | 6 1.2| Infiltration Cellular, Histiocyte | 3 3 1 | 4 2.0| Inflammation, Acute | 3 | 1 3.0| Inflammation, Chronic Active | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7| | | 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolar Epithelium, Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Nose | + + + M + + + + + + + + + + + + + + + + + + + +| 47 | Inflammation, Acute | 2 | 2 2.0| Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 5 | Cornea, Inflammation, Acute | | 1 1.0| Lens, Cataract | | 1 2.0| __________________________________________________________________________|____________| Zymbal's Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | X X X | 6 | Inflammation, Granulomatous | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | X X X | 4 | Nephropathy | 3 2 3 3 3 3 2 3 2 3 2 2 1 1 3 3 2 2 1 3 3 3 2 3| 49 2.5| Cortex, Mineralization | 1 1 1 | 5 1.2| Papilla, Mineralization | 1 1 | 4 1.0| Renal Tubule, Necrosis | 1 | 1 1.0| Renal Tubule, Pigmentation | 1 1 | 3 1.0| Transitional Epithelium, Hyperplasia | | 2 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + M + + + + + + + + + + + + + + M + + + + +| 46 | Calculus Micro Observation Only | X | 1 | Artery, Necrosis, Fibrinoid | | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 1| 9| 4| 3| 3| 3| 3| 2| 3| 3| 1| 3| 6| | 6| 6| 6| 1| 2| 6| 6| 6| 6| 0| 6| 6| 6| 5| 0| 7| 6| 6| 5| 3| 7| 0| 1| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + M +| __________________________________________________________________________| Intestine Large, Colon | + + + + + +| Parasite | 1 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + M| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 1 2 2 | Basophilic Focus | X X X X X X X X X | Clear Cell Focus | X X X | Degeneration, Cystic | 1 | Developmental Malformation | X | Eosinophilic Focus | X | Fatty Change, Diffuse | | Fatty Change, Focal | 2 2| Hepatodiaphragmatic Nodule | X | Hyperplasia, Focal | | Hyperplasia | 2 | Hyperplasia, Multifocal | | Inflammation, Granulomatous | | Mixed Cell Focus | X X X X X X X | Necrosis | | Pigmentation | | Thrombosis | 2 2 | Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | __________________________________________________________________________| Mesentery | + | Fat, Necrosis | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 | Acinus, Hyperplasia, Focal | | Acinus, Hyperplasia | 2 2 | Artery, Hemorrhage | | Artery, Inflammation, Chronic Active | | Artery, Necrosis, Fibrinoid | 2 1 | __________________________________________________________________________| Salivary Glands | + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Stomach | + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + +| Acanthosis | 2 | Inflammation, Chronic | 2 | _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 1| 9| 4| 3| 3| 3| 3| 2| 3| 3| 1| 3| 6| | 6| 6| 6| 1| 2| 6| 6| 6| 6| 0| 6| 6| 6| 5| 0| 7| 6| 6| 5| 3| 7| 0| 1| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Ulcer | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + +| Erosion | 2 | Infiltration Cellular, Lymphocyte | | Inflammation, Chronic | 2 | Necrosis | | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + +| Cardiomyopathy | 2 2 2 2 2 2 2| Thrombosis | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + +| Hypertrophy | 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + +| Hyperplasia | 2 2 2 2 1| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + M +| Hyperplasia, Focal | | Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + M + + M M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + +| Pars Distalis, Angiectasis | 3 2 2 2 2 | Pars Distalis, Hyperplasia | 2 2| Pars Intermedia, Hyperplasia | 2| __________________________________________________________________________| Thyroid Gland | + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + +| Inflammation, Acute | | Necrosis | | __________________________________________________________________________| Prostate | + + + + + + + + +| Inflammation, Chronic Active | 2 2| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 2 2 1 2 1 2 1 1 1 2| Seminiferous Tubule, Atrophy | 3 3 2 2 3 2 3 3 3 2 2 2 3 4 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 1| 9| 4| 3| 3| 3| 3| 2| 3| 3| 1| 3| 6| | 6| 6| 6| 1| 2| 6| 6| 6| 6| 0| 6| 6| 6| 5| 0| 7| 6| 6| 5| 3| 7| 0| 1| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________| Bone Marrow | + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + +| Axillary, Infiltration Cellular, | | Plasma Cell | | Inguinal, Infiltration Cellular, | | Plasma Cell | | Lumbar, Infiltration Cellular, | | Histiocyte | | Mediastinal, Angiectasis | 2 2 | Mediastinal, Infiltration Cellular, | | Histiocyte | | Mediastinal, Pigmentation | | Pancreatic, Angiectasis | | Pancreatic, Infiltration Cellular, | | Histiocyte | | Renal, Infiltration Cellular, | | Histiocyte | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + +| Angiectasis | 2 | Degeneration, Cystic | | Infiltration Cellular, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + +| Angiectasis | 2 | Hemorrhage | 3 | Infiltration Cellular, Plasma Cell | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 2 | Fibrosis | 2 3 | Hematopoietic Cell Proliferation | 1 2 2 2 2 1 | Hemorrhage | 1 | Mineralization | | Necrosis | | Pigmentation | 3 | Thrombosis | | __________________________________________________________________________| Thymus | + M M + M + + + + + +| Depletion Lymphoid | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + M| __________________________________________________________________________| Skin | + + + + + + + + + + +| Acanthosis | 2 2 | Cyst Epithelial Inclusion | | Hyperkeratosis | 3 4 | _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 1| 9| 4| 3| 3| 3| 3| 2| 3| 3| 1| 3| 6| | 6| 6| 6| 1| 2| 6| 6| 6| 6| 0| 6| 6| 6| 5| 0| 7| 6| 6| 5| 3| 7| 0| 1| 0| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | __________________________________________________________________________| Spinal Cord | | Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + +| Atelectasis | 2| Congestion | 2 2 2 2 2 | Edema | | Hemorrhage | | Infiltration Cellular, Histiocyte | | __________________________________________________________________________| Nose | + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + + + + + | Lens, Cataract | 2 3 | __________________________________________________________________________| Harderian Gland | + + + | __________________________________________________________________________| Zymbal's Gland | M + + + + + + + + + M + + + + + M + + + + + + + +| Cyst | | Hyperplasia | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Cyst | | Necrosis | | Nephropathy | 3 3 3 2 3 3 3 3 3 2 3 3 3 2 2 2 3 4 2 2 3 2 3 2 2| Papilla, Mineralization | | Renal Tubule, Hyperplasia | 1 1 | Renal Tubule, Pigmentation | | Transitional Epithelium, Hyperplasia | 1 2 2 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + +| Calculus Gross Observation | X | Calculus Micro Observation Only | X X| _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6| | | 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + M + +| 14 | __________________________________________________________________________|____________| Intestine Large | + + + +| 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A + +| 8 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + +| 10 | Parasite | 1| 2 1.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + A + +| 9 | __________________________________________________________________________|____________| Intestine Small | + A + +| 9 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + A + +| 9 | __________________________________________________________________________|____________| Intestine Small, Ileum | + A + A| 7 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + +| 9 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 1 | 7 1.7| Basophilic Focus | X X X X X X X X X X| 19 | Clear Cell Focus | X | 4 | Degeneration, Cystic | 1 1 2 2 1 | 6 1.3| Developmental Malformation | X | 2 | Eosinophilic Focus | | 1 | Fatty Change, Diffuse | 2 | 1 2.0| Fatty Change, Focal | 1 1 | 4 1.5| Hepatodiaphragmatic Nodule | | 1 | Hyperplasia, Focal | 2 | 1 2.0| Hyperplasia | 2 | 2 2.0| Hyperplasia, Multifocal | 2 | 1 2.0| Inflammation, Granulomatous | 1 | 1 1.0| Mixed Cell Focus | X X | 9 | Necrosis | 2 | 1 2.0| Pigmentation | 3 | 1 3.0| Thrombosis | | 2 2.0| Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 31 2.0| __________________________________________________________________________|____________| Mesentery | + | 2 | Fat, Necrosis | | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | Acinus, Atrophy | 3 | 2 2.5| Acinus, Hyperplasia, Focal | 1 | 1 1.0| Acinus, Hyperplasia | 2 2 2 2 | 6 2.0| Artery, Hemorrhage | 2 | 1 2.0| Artery, Inflammation, Chronic Active | 1 3 | 2 2.0| Artery, Necrosis, Fibrinoid | | 2 1.5| __________________________________________________________________________|____________| Salivary Glands | + + + + + +| 13 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6| | | 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach | + + + + + + + + + +| 18 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + +| 14 | Acanthosis | 3 2 2 | 4 2.3| Inflammation, Chronic | 3 | 2 2.5| Ulcer | 4 | 2 3.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + A + + + +| 15 | Erosion | 2 2 | 3 2.0| Infiltration Cellular, Lymphocyte | 3 2 | 2 2.5| Inflammation, Chronic | 2 | 2 2.0| Necrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + +| 15 | Cardiomyopathy | 2 2 2 2 2 2| 13 2.0| Thrombosis | 2 | 3 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + +| 18 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + +| 18 | Hypertrophy | | 1 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + +| 18 | Hyperplasia | | 5 1.8| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + +| 45 | Hyperplasia, Focal | 2 | 1 2.0| Hyperplasia | 3 | 2 2.5| __________________________________________________________________________|____________| Parathyroid Gland | M + + + + M + M| 9 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + +| 20 | Pars Distalis, Angiectasis | 2 2 2 2 2 1| 11 2.0| Pars Distalis, Hyperplasia | 2 | 3 2.0| Pars Intermedia, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + +| 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + +| 13 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 42 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6| | | 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + M + + +| 22 | Inflammation, Acute | 2 3 | 2 2.5| Necrosis | 2| 1 2.0| __________________________________________________________________________|____________| Prostate | + + + +| 13 | Inflammation, Chronic Active | 2 | 3 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + +| 23 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Hyperplasia | 1 2 2 2 2 2 1 1 1 2 2 2 2| 23 1.6| Seminiferous Tubule, Atrophy | 2 2 3 2 2 3 3 2 3 2 4 2 2 2 2 2 | 32 2.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + +| 10 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + +| 30 | Axillary, Infiltration Cellular, | | | Plasma Cell | 2 | 1 2.0| Inguinal, Infiltration Cellular, | | | Plasma Cell | 2 | 1 2.0| Lumbar, Infiltration Cellular, | | | Histiocyte | 2 | 1 2.0| Mediastinal, Angiectasis | | 2 2.0| Mediastinal, Infiltration Cellular, | | | Histiocyte | 2 | 1 2.0| Mediastinal, Pigmentation | 2 | 1 2.0| Pancreatic, Angiectasis | 2 | 1 2.0| Pancreatic, Infiltration Cellular, | | | Histiocyte | 2 2 2 | 3 2.0| Renal, Infiltration Cellular, | | | Histiocyte | 3 | 2 2.5| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + +| 20 | Angiectasis | | 1 2.0| Degeneration, Cystic | 2 | 1 2.0| Infiltration Cellular, Plasma Cell | 3 3 | 2 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + +| 15 | Angiectasis | | 1 2.0| Hemorrhage | | 1 3.0| Infiltration Cellular, Plasma Cell | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + +| 36 | Depletion Lymphoid | | 1 2.0| Fibrosis | | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 43 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6| | | 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2| 14 1.9| Hemorrhage | 2 3 3 | 4 2.3| Mineralization | 1 | 1 1.0| Necrosis | 2 | 1 2.0| Pigmentation | 2 | 2 2.5| Thrombosis | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + +| 17 | Depletion Lymphoid | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + M| 9 | __________________________________________________________________________|____________| Skin | + + + + + + +| 18 | Acanthosis | 2 2 | 4 2.0| Cyst Epithelial Inclusion | X X | 2 | Hyperkeratosis | 4 4 | 4 3.8| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + +| 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Spinal Cord | +| 1 | Hemorrhage | 2| 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + +| 28 | Atelectasis | | 1 2.0| Congestion | 2 2 3 3 2 | 10 2.2| Edema | 1 | 1 1.0| Hemorrhage | 1 1 | 2 1.0| Infiltration Cellular, Histiocyte | 3 | 1 3.0| __________________________________________________________________________|____________| Nose | + + + +| 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + +| 27 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | __________________________________________________________________________|____________| Eye | + + + +| 9 | Lens, Cataract | 2 | 3 2.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 44 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6| | | 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Harderian Gland | + + + +| 7 | __________________________________________________________________________|____________| Zymbal's Gland | M + + + + + + + + + + + + + + M + + + + + + + + +| 45 | Cyst | X | 1 | Hyperplasia | | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 2.0| Cyst | X | 1 | Necrosis | 2 | 1 2.0| Nephropathy | 2 2 3 3 2 3 3 3 3 2 2 3 3 3 2 3 4 3 1 3 3 2 2 1| 49 2.6| Papilla, Mineralization | 1 | 1 1.0| Renal Tubule, Hyperplasia | 1 | 3 1.0| Renal Tubule, Pigmentation | 3 | 1 3.0| Transitional Epithelium, Hyperplasia | 1 1 1 1 | 8 1.3| __________________________________________________________________________|____________| Urinary Bladder | + + + A| 10 | Calculus Gross Observation | | 1 | Calculus Micro Observation Only | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 45 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| DAY ON TEST | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4| | 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| Parasite | 1 1 1 1 1 1 1 | __________________________________________________________________________| Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +| Parasite | 1 2 | __________________________________________________________________________| Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + A + + + + + + M + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +| Lymphoid Tissue, Hyperplasia | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 1 | Basophilic Focus | X X X X X X X X X X X X X X X | Clear Cell Focus | X X | Congestion | 1 | Degeneration, Cystic | 1 1 1 2 1| Developmental Malformation | | Fatty Change, Diffuse | 2 | Fatty Change, Focal | 2 | Focal Cellular Change | X X X | Hemorrhage | | Hyperplasia, Focal | 2 | Hyperplasia, Multifocal | | Inflammation | | Mixed Cell Focus | X | Necrosis | 2 | Bile Duct, Hyperplasia | 1 1 1 2 2 2 2 1 1 2 2 2 2 2 2 2 2 1| __________________________________________________________________________| Mesentery | + + + + + + + | Hemorrhage | 3 | Fat, Mineralization | 1 | Fat, Necrosis | 2 3 3 3 | Fat, Pigmentation | 2 3 | __________________________________________________________________________| Pancreas | + + + + M + + + + + + + + + + + + + M + + + + + +| Fibrosis | | Acinus, Hyperplasia, Focal | 1 | Acinus, Hyperplasia | 1 | Artery, Necrosis, Fibrinoid | 3 | Duct, Hyperplasia | | __________________________________________________________________________| Pharynx | | Palate, Epithelium, Hyperplasia | | __________________________________________________________________________| Salivary Glands | + M + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| DAY ON TEST | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4| | 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 | Edema | | Hyperkeratosis | 1 2 2 1 | Hyperplasia, Basal Cell | 3 | Inflammation, Chronic Active | | __________________________________________________________________________| Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +| Degeneration | 1 | Hyperplasia | 2 2 | Infiltration Cellular, Lymphocyte | 3 | Mineralization | 2 | Necrosis | | Pigmentation | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 1 2 2 2 1 2 2 1 2 3 2 1 1 2 2 2 2 2 2 2 2 2 2| Inflammation, Acute | 2 | Mineralization | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + M + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Hyperplasia | 1 | Vacuolization Cytoplasmic, Diffuse | 1 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 1 1 2 2 1 1 1 1 2 1 2| __________________________________________________________________________| Islets, Pancreatic | + + + + M + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + + M + M + + + + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 3 2 2 | Pars Distalis, Hyperplasia | 2 2 1 1 1 2 1 2 1 2 2| Pars Intermedia, Hyperplasia | 2 1 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 2 1 | Follicle, Cyst | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Necrosis | 2 | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | + | _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| DAY ON TEST | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4| | 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 | Hyperplasia | 3 | Inflammation, Chronic Active | 1 1 | Necrosis | 3 3 3 3 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 3 2| Inflammation | | Mineralization | 1 | Necrosis | 2 | Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 1 1 1 2 1 1 1 1 1 1 2| Seminiferous Tubule, Atrophy | 1 2 1 1 1 1 2 2 2 2 2 2 2 2 2 2 2 2 1| Seminiferous Tubule, Mineralization | 1 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Reticulum Cell | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Lumbar, Pigmentation | 2 | Mediastinal, Congestion | | Mediastinal, Depletion Lymphoid | 3 | Mediastinal, Pigmentation | 2 | Pancreatic, Cyst | X | Pancreatic, Depletion Lymphoid | 2 | Pancreatic, Hematocyst | X | Pancreatic, Hemorrhage | | Pancreatic, Infiltration Cellular, | | Plasma Cell | 2 | Pancreatic, Infiltration Cellular, | | Histiocyte | | Renal, Infiltration Cellular, | | Histiocyte | 2 | Renal, Pigmentation | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Degeneration, Cystic | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Degeneration, Cystic | 2 | Hemorrhage | | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| DAY ON TEST | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4| | 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Infiltration Cellular, Histiocyte | 2 | Necrosis | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Depletion Lymphoid | | Fibrosis | | Hematopoietic Cell Proliferation | 2 1 1 1 2 1 1 2 3 2 1 2 3 2 2 1 2 | Pigmentation | 2 1 2 1 1 2 1 | __________________________________________________________________________| Thymus | + + M + M + + + + + + + + + + + + + + + + M +| Depletion Lymphoid | 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + M M + M + + M + + + + M M + + + M + + + + M| Galactocele | X X | Acinus, Hyperplasia | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 2 | Erosion | | Hemorrhage | | Hyperkeratosis | 3 4 | Inflammation, Chronic Active | | Necrosis | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Tarsal, Hyperostosis | 2| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 1 1 2 2 2 | Edema | 2 | Hemorrhage | 1 1 | Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 | Inflammation, Chronic Active | 1 | Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | Inflammation, Acute | 2 2 2 2 1 | Inflammation, Chronic Active | | Metaplasia, Osseous | 2 | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| DAY ON TEST | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4| | 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + + | __________________________________________________________________________| Eye | + + + | Lens, Cataract | | __________________________________________________________________________| Harderian Gland | + | __________________________________________________________________________| Zymbal's Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Fibrosis | 1 | Hydronephrosis | 1 4 | Nephropathy | 3 3 3 3 2 2 2 3 3 2 3 3 3 3 3 3 3 3 2 3 4 3 2 3| Capsule, Fibrosis | | Cortex, Mineralization | 1 2 1 1 1 | Papilla, Mineralization | 1 1 1 1 1 1 | Renal Tubule, Dilatation | 3 | Renal Tubule, Necrosis | 1 | Renal Tubule, Pigmentation | 2 1 | Transitional Epithelium, Hyperplasia | 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| Calculus Gross Observation | X | Calculus Micro Observation Only | X | Fibrosis | 1 | Hemorrhage | 2 | Inflammation, Chronic Active | 2 | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| | | 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + A| 47 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 | Parasite | 2 2 1 1 1 2 1 | 14 1.2| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 | Parasite | | 2 1.5| __________________________________________________________________________|____________| Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + M + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + A| 47 | Lymphoid Tissue, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + + A + + + + + + + + + + + + + + + + A| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 3 2 1 1 | 8 1.6| Basophilic Focus | X X X X X X X X X X | 25 | Clear Cell Focus | X | 3 | Congestion | | 1 1.0| Degeneration, Cystic | 2 | 6 1.3| Developmental Malformation | X | 1 | Fatty Change, Diffuse | | 1 2.0| Fatty Change, Focal | 2 1 1 1 | 5 1.4| Focal Cellular Change | X X X X X | 8 | Hemorrhage | 4 1 | 2 2.5| Hyperplasia, Focal | 2 3 4 3 | 5 2.8| Hyperplasia, Multifocal | 2 | 1 2.0| Inflammation | 1 | 1 1.0| Mixed Cell Focus | X X | 3 | Necrosis | 3 1 3| 4 2.3| Bile Duct, Hyperplasia | 2 1 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 | 35 1.8| __________________________________________________________________________|____________| Mesentery | + + | 9 | Hemorrhage | | 1 3.0| Fat, Mineralization | | 1 1.0| Fat, Necrosis | 2 4 | 6 2.8| Fat, Pigmentation | 3 | 3 2.7| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Fibrosis | 2 | 1 2.0| Acinus, Hyperplasia, Focal | | 1 1.0| Acinus, Hyperplasia | 2 | 2 1.5| Artery, Necrosis, Fibrinoid | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 51 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| | | 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Duct, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Pharynx | +| 1 | Palate, Epithelium, Hyperplasia | 4| 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Acanthosis | 2 | 2 1.5| Edema | 2 | 1 2.0| Hyperkeratosis | 2 2 2 | 7 1.7| Hyperplasia, Basal Cell | | 1 3.0| Inflammation, Chronic Active | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + +| 47 | Degeneration | | 1 1.0| Hyperplasia | 1 | 3 1.7| Infiltration Cellular, Lymphocyte | 2 | 2 2.5| Mineralization | 1 | 2 1.5| Necrosis | 2 | 1 2.0| Pigmentation | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 47 1.9| Inflammation, Acute | | 1 2.0| Mineralization | | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 | Hemorrhage | | 1 2.0| Hyperplasia | 1 | 2 1.0| Vacuolization Cytoplasmic, Diffuse | | 1 1.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 | Hyperplasia | 1 2 2 2 1 1 1 2| 21 1.4| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M M + + + + + + + + + M M + + + + + + + +| 42 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | 2 2 3 | 6 2.3| Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 1 2 2 | 21 1.7| Pars Intermedia, Hyperplasia | | 3 1.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 52 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| | | 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 2 | 6 1.3| Follicle, Cyst | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | Necrosis | | 1 2.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | + + + + +| 6 | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | | 1 2.0| Hyperplasia | | 1 3.0| Inflammation, Chronic Active | 1 | 3 1.0| Necrosis | 1 2 | 7 2.4| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 2 3 2 2| 9 2.2| Inflammation | 2 | 1 2.0| Mineralization | | 1 1.0| Necrosis | | 1 2.0| Epithelium, Hyperplasia | 1 2 2 | 4 1.5| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Hyperplasia | 2 1 1 1 1 2 1 1 1 1 1 2 2 1 | 25 1.2| Seminiferous Tubule, Atrophy | 2 2 2 3 2 2 2 2 2 2 2 1 2 2 2 2 2 1 3 1 2 3 2 3 2| 44 1.9| Seminiferous Tubule, Mineralization | | 2 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Reticulum Cell | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lumbar, Pigmentation | | 1 2.0| Mediastinal, Congestion | 2 | 1 2.0| Mediastinal, Depletion Lymphoid | | 1 3.0| Mediastinal, Pigmentation | 2 | 2 2.0| Pancreatic, Cyst | | 1 | Pancreatic, Depletion Lymphoid | | 1 2.0| Pancreatic, Hematocyst | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 53 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| | | 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Pancreatic, Hemorrhage | 2| 1 2.0| Pancreatic, Infiltration Cellular, | | | Plasma Cell | | 1 2.0| Pancreatic, Infiltration Cellular, | | | Histiocyte | 1 | 1 1.0| Renal, Infiltration Cellular, | | | Histiocyte | | 1 2.0| Renal, Pigmentation | 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | X | 2 | Degeneration, Cystic | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 | Angiectasis | | 1 2.0| Degeneration, Cystic | 2 | 2 2.0| Hemorrhage | 2| 1 2.0| Infiltration Cellular, Histiocyte | 2 | 2 2.0| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2| 1 2.0| Depletion Lymphoid | 2 1 | 2 1.5| Fibrosis | 2 3 | 2 2.5| Hematopoietic Cell Proliferation | 2 2 1 2 2 2 1 1 1 1 1 | 28 1.6| Pigmentation | 2 2 2 2 2 2 2 1 | 15 1.7| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 | Depletion Lymphoid | 2 | 3 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + M M + M + + + + + + + M + + + + + + + + + +| 38 | Galactocele | X X X X | 6 | Acinus, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 3 3 | 4 2.5| Erosion | 4 | 1 4.0| Hemorrhage | 3 | 1 3.0| Hyperkeratosis | 3 3 3 | 5 3.2| Inflammation, Chronic Active | 2 | 1 2.0| Necrosis | 3 3 | 2 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| | | 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Tarsal, Hyperostosis | | 1 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 1 2 2 2 2 | 11 1.7| Edema | 2 | 2 2.0| Hemorrhage | 1 1 1 1 | 6 1.0| Infiltration Cellular, Histiocyte | 3 1 1 | 11 1.2| Inflammation, Chronic Active | 2 2 1 2 | 5 1.6| Alveolar Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 1.0| Inflammation, Acute | 2 2 2 | 8 1.9| Inflammation, Chronic Active | 1 | 1 1.0| Metaplasia, Osseous | | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 3 | __________________________________________________________________________|____________| Eye | + + + | 6 | Lens, Cataract | 2 | 1 2.0| __________________________________________________________________________|____________| Harderian Gland | + + + | 4 | __________________________________________________________________________|____________| Zymbal's Gland | + + M M M M M + M + + + + + + + + M + + + + + M +| 41 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X | 1 | Fibrosis | | 1 1.0| Hydronephrosis | | 2 2.5| Nephropathy | 3 2 3 3 1 3 3 1 2 3 3 3 3 3 2 2 3 3 2 2 3 2 2 2 3| 49 2.6| Capsule, Fibrosis | 2 | 1 2.0| Cortex, Mineralization | 2 1 | 7 1.3| Papilla, Mineralization | 1 1 1| 9 1.0| Renal Tubule, Dilatation | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97 Route: DOSED FEED Time: 12:56:45 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| | | 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Renal Tubule, Necrosis | | 1 1.0| Renal Tubule, Pigmentation | 2 1 1 | 5 1.4| Transitional Epithelium, Hyperplasia | 1 | 3 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 | Calculus Gross Observation | | 1 | Calculus Micro Observation Only | | 1 | Fibrosis | | 1 1.0| Hemorrhage | | 1 2.0| Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 56 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 521435-521435/521435 --multipart-boundary--