TR 365 Rat Pathology Tables
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
Facility: TSI Mason Research
Chemical CAS #: 78-11-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 2| 5| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 3| 7| 7| 7| 9| 7| 8| 8| 7| 2| 7| 8| 9| 7| 8| 0| 8| 8| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + M + +|
Parasite | 1|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + M A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Congestion | 2 |
Developmental Malformation | X X |
Eosinophilic Focus | X |
Fatty Change, Diffuse | 1 2 2 2 |
Fatty Change, Focal | 1 1 1 |
Focal Cellular Change | |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | |
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic Active | 1 |
Inflammation, Granulomatous | 1 |
Mixed Cell Focus | X X |
Necrosis | |
Bile Duct, Hyperplasia | 2 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Hemorrhage | |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Mineralization | 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 2| 5| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 3| 7| 7| 7| 9| 7| 8| 8| 7| 2| 7| 8| 9| 7| 8| 0| 8| 8| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 1 2 2 1 2 2 |
Artery, Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + M + + M + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hyperplasia | 2 |
Pars Distalis, Angiectasis | 4 2 2 1 2 2 1 2 2 3 2 2 1 1 2 2|
Pars Distalis, Cyst | |
Pars Distalis, Cyst, Multiple | X |
Pars Distalis, Hyperplasia | 2 2 3 2 2 2 2 1 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 2 2 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + M M M + + + + + M + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 2 |
Necrosis | 2 3 2 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 1 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 2| 5| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 3| 7| 7| 7| 9| 7| 8| 8| 7| 2| 7| 8| 9| 7| 8| 0| 8| 8| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Pigmentation | 2 |
Pancreatic, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + M M + +|
Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2|
Hemorrhage | |
Hyperplasia, Reticulum Cell | |
Necrosis | 2 |
Pigmentation | 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + M + + + + + + + + + + + +|
Epithelial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Galactocele | X X X X X X X X X X X X X X X X X X X|
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + M + + + + + + + + + + + + +|
Acanthosis | 3 |
Hemorrhage | 2 |
Hyperkeratosis | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Edema | |
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 2| 5| 3| 3| 3| 1| 6| 3| 3| 3| 3| 3|
| 7| 7| 7| 7| 3| 7| 7| 7| 9| 7| 8| 8| 7| 2| 7| 8| 9| 7| 8| 0| 8| 8| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Acanthosis | |
Hyperkeratosis | |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Zymbal's Gland | + + + M + + + M + + + + + M + + M + + + + M M + +|
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 1 2 1 2 2 2 1 3 2 3 1 1 1 3 2 1 1 1 1 1 2 2 1|
Cortex, Mineralization | 1 1 |
Renal Tubule, Pigmentation | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 4| 2| 4| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 3| 3| 3| 4| 6| |
| 8| 8| 8| 0| 4| 8| 8| 4| 8| 1| 8| 9| 9| 6| 0| 8| 8| 8| 9| 2| 9| 8| 8| 7| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + A + + + + + A + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + + + A + + + + + + + + + +| 48 |
Parasite | 1 2 2 2| 5 1.6|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + A + + + + + A + + + + + + + + + +| 46 |
Parasite | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X| 41 |
Clear Cell Focus | X | 1 |
Congestion | | 1 2.0|
Developmental Malformation | | 2 |
Eosinophilic Focus | | 1 |
Fatty Change, Diffuse | 3 2 | 6 2.0|
Fatty Change, Focal | 1 | 4 1.0|
Focal Cellular Change | X X | 2 |
Hepatodiaphragmatic Nodule | X | 2 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic, Focal | | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
Inflammation, Granulomatous | | 1 1.0|
Mixed Cell Focus | X | 3 |
Necrosis | 1 | 1 1.0|
Bile Duct, Hyperplasia | 2 1 | 4 1.8|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Hemorrhage | 2 | 1 2.0|
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 1| 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 4| 2| 4| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 3| 3| 3| 4| 6| |
| 8| 8| 8| 0| 4| 8| 8| 4| 8| 1| 8| 9| 9| 6| 0| 8| 8| 8| 9| 2| 9| 8| 8| 7| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Mineralization | 1 | 2 1.0|
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 28 1.9|
Artery, Necrosis, Fibrinoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Degeneration | | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Hyperplasia | 1 1 1 1| 6 1.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + M M + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 2.0|
Hyperplasia | 2 | 2 2.0|
Pars Distalis, Angiectasis | 2 2 2 2 2 3 2 2 3 2 2 2| 28 2.0|
Pars Distalis, Cyst | X X | 2 |
Pars Distalis, Cyst, Multiple | | 1 |
Pars Distalis, Hyperplasia | 3 2 2 2 2 2 | 15 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1| 7 1.3|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + M + + M + + + + + + M + + + M + M + +| 39 |
Hyperplasia | 2 1| 3 1.7|
Inflammation, Chronic Active | | 1 2.0|
Necrosis | 2 3 2 | 7 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 4| 2| 4| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 3| 3| 3| 4| 6| |
| 8| 8| 8| 0| 4| 8| 8| 4| 8| 1| 8| 9| 9| 6| 0| 8| 8| 8| 9| 2| 9| 8| 8| 7| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 4 |
__________________________________________________________________________|____________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Vagina | + + | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Angiectasis | | 1 1.0|
Mediastinal, Pigmentation | 1 | 2 1.5|
Pancreatic, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Depletion Lymphoid | 1 | 1 1.0|
Fibrosis | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 2 1 1 2 3 1 2 2 2 2 2 2 1 2 2 2 2| 33 1.9|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Reticulum Cell | 3 | 1 3.0|
Necrosis | | 1 2.0|
Pigmentation | 2 2 2 2 1 2 2 2 2 2 2 2 2| 33 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + + + M + + + + + +| 46 |
Epithelial Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + M + + + + + + M + + + + + + + + +| 46 |
Galactocele | X X X X X X X X X X X X X X X X| 35 |
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | | 1 3.0|
Hemorrhage | | 1 2.0|
Hyperkeratosis | 4 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 6| 6| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 4| 2| 4| 3| 3| 3| 4| 1| 3| 3| 3| 3| 8| 3| 3| 3| 4| 6| |
| 8| 8| 8| 0| 4| 8| 8| 4| 8| 1| 8| 9| 9| 6| 0| 8| 8| 8| 9| 2| 9| 8| 8| 7| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | +| 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 1 2 | 4 1.8|
Edema | 1 | 1 1.0|
Hemorrhage | 1 1 1 2 | 6 1.2|
Infiltration Cellular, Histiocyte | 1 1 1 1 | 5 1.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 2 |
Acanthosis | 3 | 1 3.0|
Hyperkeratosis | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Eye | + +| 6 |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + M M + M + + M + + + M + M + + + M M +| 36 |
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 2 2 2 1 2 2 2 1 2 2 1 2 2 2 2 2 2 1 1 1 2| 46 1.7|
Cortex, Mineralization | 1 1 | 4 1.0|
Renal Tubule, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8|
| 7| 7| 7| 8| 9| 7| 7| 7| 2| 5| 7| 7| 7| 7| 5| 7| 7| 7| 3| 9| 7| 7| 7| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.62% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + +|
__________________________________________________________________________|
Intestine Small | + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + +|
Lymphoid Nodule, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Eosinophilic Focus | X |
Fatty Change, Diffuse | 2 3 |
Fatty Change, Focal | 1 2 1 2|
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia | 2 1 |
Mixed Cell Focus | X |
Necrosis | |
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + |
Artery, Inflammation, Chronic Active | 1 |
Artery, Pigmentation | 2 |
Artery, Thrombosis | 3 |
Fat, Necrosis | 3 |
Fat, Pigmentation | |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Stomach | + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + +|
Acanthosis | |
Hyperkeratosis | |
Inflammation, Chronic Active | |
Necrosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + +|
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + +|
Cardiomyopathy | 2 2 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8|
| 7| 7| 7| 8| 9| 7| 7| 7| 2| 5| 7| 7| 7| 7| 5| 7| 7| 7| 3| 9| 7| 7| 7| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.62% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 3 2 3 2|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 |
Pars Intermedia, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
C-Cell, Hyperplasia | 2 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + M + +|
Hyperplasia | 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 |
Necrosis | 3 |
__________________________________________________________________________|
Ovary | + + + + +|
Cyst | X |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + +|
Mediastinal, Angiectasis | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
Renal, Angiectasis | 2 |
Renal, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + + M|
Degeneration, Cystic | 2 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8|
| 7| 7| 7| 8| 9| 7| 7| 7| 2| 5| 7| 7| 7| 7| 5| 7| 7| 7| 3| 9| 7| 7| 7| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.62% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + +|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 2 2 2 2 |
Necrosis | |
Pigmentation | 2 3 3 |
__________________________________________________________________________|
Thymus | + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + +|
Galactocele | X X X X X X |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + +|
Hydrocephalus | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Fibrosis | 3 |
Hemorrhage | 1 |
Inflammation, Chronic Active | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + +|
__________________________________________________________________________|
Eye | + + + +|
Lens, Cataract | |
Retina, Atrophy | 2 2 |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Zymbal's Gland | M M M M + M + + + + + + M + + + + + + + M + + M +|
Cyst | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 0| 3| 3| 3| 3| 2| 8| 3| 3| 3| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 9| 8|
| 7| 7| 7| 8| 9| 7| 7| 7| 2| 5| 7| 7| 7| 7| 5| 7| 7| 7| 3| 9| 7| 7| 7| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.62% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 2 1 2 2 2 2 2 2 1 2 2 1 1 2 2 2 |
Cortex, Mineralization | |
Cortex, Necrosis | 2 |
Papilla, Mineralization | |
Pelvis, Mineralization | 1 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 2|
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + +|
Hemorrhage | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 5| 5| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 7| 4| 0| 3| 3| 8| 4| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| |
| 7| 7| 3| 1| 0| 7| 7| 5| 7| 3| 7| 7| 7| 7| 8| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.62% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + M + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + +| 14 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + +| 13 |
Lymphoid Nodule, Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 | 2 1.5|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 41 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X X | 3 |
Fatty Change, Diffuse | 3 3 2 | 5 2.6|
Fatty Change, Focal | | 4 1.5|
Hepatodiaphragmatic Nodule | X X X X | 7 |
Hyperplasia | | 2 1.5|
Mixed Cell Focus | | 1 |
Necrosis | 3 1 | 2 2.0|
Bile Duct, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Artery, Inflammation, Chronic Active | | 1 1.0|
Artery, Pigmentation | | 1 2.0|
Artery, Thrombosis | | 1 3.0|
Fat, Necrosis | 3 | 2 3.0|
Fat, Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 17 |
Artery, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 13 |
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 11 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 11 |
Acanthosis | 3 | 1 3.0|
Hyperkeratosis | 3 | 1 3.0|
Inflammation, Chronic Active | 2 1 | 2 1.5|
Necrosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 5| 5| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 7| 4| 0| 3| 3| 8| 4| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| |
| 7| 7| 3| 1| 0| 7| 7| 5| 7| 3| 7| 7| 7| 7| 8| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.62% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 10 |
Cardiomyopathy | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 12 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M M + + + + M + + + + + + + + +| 36 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +| 30 |
Pars Distalis, Angiectasis | 2 2 2 3 3 2 2 2 1 3 2 2| 18 2.3|
Pars Distalis, Cyst | X | 3 |
Pars Distalis, Hyperplasia | 2 2 | 3 2.0|
Pars Intermedia, Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
C-Cell, Hyperplasia | 2 1 1 1 | 9 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + M M + + + + | 12 |
Hyperplasia | | 1 2.0|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | 1 | 2 1.5|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 15 |
Cyst | X X X | 4 |
__________________________________________________________________________|____________|
Oviduct | + | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pigmentation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 5| 5| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 7| 4| 0| 3| 3| 8| 4| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| |
| 7| 7| 3| 1| 0| 7| 7| 5| 7| 3| 7| 7| 7| 7| 8| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.62% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Angiectasis | 3 | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 2 | 2 2.0|
Renal, Angiectasis | | 1 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + | 11 |
Degeneration, Cystic | | 1 2.0|
Infiltration Cellular, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 12 |
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + | 26 |
Depletion Lymphoid | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 3 3 2 2 2 2 | 12 2.1|
Necrosis | 3 | 1 3.0|
Pigmentation | 2 3 2 3 2 2 2 | 10 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + + M | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + | 34 |
Galactocele | X X X X X X X X X | 15 |
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 10 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 10 |
Hydrocephalus | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 2 3 2 3 2 2 2 2 3 2 2 2| 30 2.1|
Fibrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 5| 5| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 7| 4| 0| 3| 3| 8| 4| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| |
| 7| 7| 3| 1| 0| 7| 7| 5| 7| 3| 7| 7| 7| 7| 8| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
0.62% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | 2 1 | 3 1.3|
Inflammation, Chronic Active | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2| 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + +| 39 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | + + + | 7 |
Lens, Cataract | 2 | 1 2.0|
Retina, Atrophy | | 2 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + M + + + + + + M M M M + + + + + + + + +| 37 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 2 2 4 3 1 2 1 2 2 2 1 1 1 3 1 2 1 2 1 1 2| 39 1.8|
Cortex, Mineralization | 1 | 1 1.0|
Cortex, Necrosis | | 1 2.0|
Papilla, Mineralization | 1 | 1 1.0|
Pelvis, Mineralization | | 1 1.0|
Renal Tubule, Hyperplasia | 2| 1 2.0|
Renal Tubule, Pigmentation | | 1 2.0|
Transitional Epithelium, Hyperplasia | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 10 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 4| 3| 3| 3| 0| 6| 3| 3| 0| 8| 4|
| 5| 5| 5| 5| 4| 5| 5| 5| 4| 8| 5| 5| 5| 5| 1| 5| 5| 5| 8| 2| 6| 5| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.25% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + M + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite | 2 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Nodule, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Nodule, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X |
Congestion | 2 |
Developmental Malformation | X X |
Eosinophilic Focus | X |
Fatty Change, Diffuse | 2 2 |
Fatty Change, Focal | 1 2 1 1 2 |
Focal Cellular Change | X X |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic Active | |
Mixed Cell Focus | X X X |
Necrosis | 2 |
Bile Duct, Hyperplasia | 2 2 |
__________________________________________________________________________|
Mesentery | + +|
Fat, Hemorrhage | 3 |
Fat, Necrosis | 1|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Pharynx | |
Palate, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | 2 |
Necrosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 4| 3| 3| 3| 0| 6| 3| 3| 0| 8| 4|
| 5| 5| 5| 5| 4| 5| 5| 5| 4| 8| 5| 5| 5| 5| 1| 5| 5| 5| 8| 2| 6| 5| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.25% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 1 2 |
Artery, Necrosis, Fibrinoid | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Necrosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 3 |
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + M + M + + + + + + + + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Pars Distalis, Angiectasis | 2 2 1 2 2 2 1 2 2 2 2 1 3|
Pars Distalis, Cyst | |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 2 |
Pars Distalis, Pigmentation | 1 |
Pars Nervosa, Cyst, Multiple | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
C-Cell, Hyperplasia | 1 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + + + + + M + + M + + + + + M M|
Dilatation | 3 |
Hyperplasia | 2 |
Inflammation, Chronic Active | 1 |
Necrosis | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
Endometrium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 4| 3| 3| 3| 0| 6| 3| 3| 0| 8| 4|
| 5| 5| 5| 5| 4| 5| 5| 5| 4| 8| 5| 5| 5| 5| 1| 5| 5| 5| 8| 2| 6| 5| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.25% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + M + + + + + + + + + +|
Mediastinal, Congestion | |
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | |
Renal, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + M + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + M + + + + +|
Congestion | 2 |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2 2 2 1 2 2 2 2 2|
Necrosis | |
Pigmentation | 2 2 2 2 2 2 3 2 2 2 2 2 3 2 2 2 2 3 2 2 2 2 2|
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + M + + +|
Depletion Lymphoid | 2 |
Epithelial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + M|
Galactocele | X X X X X X X X X X X X X X X |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Mineralization | 1 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Edema | 3 |
Hemorrhage | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 3| 0| 3| 3| 3| 3| 4| 3| 3| 3| 0| 6| 3| 3| 0| 8| 4|
| 5| 5| 5| 5| 4| 5| 5| 5| 4| 8| 5| 5| 5| 5| 1| 5| 5| 5| 8| 2| 6| 5| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.25% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 1 1 2 1 1 |
Mineralization | 2 |
Necrosis | |
Goblet Cell, Hypertrophy | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cornea, Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Harderian Gland | + + |
Abscess | 3 |
Pigmentation | 3 |
__________________________________________________________________________|
Zymbal's Gland | + + M + + + + + + + + + + + + + + M M + + + M M M|
Cyst | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Nephropathy | 2 1 1 3 2 2 3 2 2 1 2 2 1 1 2 2 3 2 3 1 2 2 2 2 2|
Cortex, Mineralization | 1 1 1 1 1 |
Papilla, Mineralization | 1 1 |
Pelvis, Mineralization | |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8| |
| 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
1.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Hyperkeratosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A M + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite | 1 1 1 1 1 | 7 1.1|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Lymphoid Nodule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Lymphoid Nodule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 3 1.7|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 43 |
Clear Cell Focus | | 1 |
Congestion | | 1 2.0|
Developmental Malformation | X | 3 |
Eosinophilic Focus | | 1 |
Fatty Change, Diffuse | 2 2 | 4 2.0|
Fatty Change, Focal | 1 1 2 | 8 1.4|
Focal Cellular Change | X| 3 |
Hepatodiaphragmatic Nodule | X X | 3 |
Inflammation, Chronic Active | 2 | 1 2.0|
Mixed Cell Focus | | 3 |
Necrosis | | 1 2.0|
Bile Duct, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Hemorrhage | | 1 3.0|
Fat, Necrosis | 4 3 | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Acinus, Atrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Palate, Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + M + + + + + + + + + + + M + +| 48 |
Acanthosis | 1 1 1 1 | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8| |
| 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
1.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis | 2 1 2 1 1 2 | 7 1.6|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 4 1.3|
Mineralization | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2| 23 2.0|
Artery, Necrosis, Fibrinoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Hyperplasia | 2 | 2 1.5|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Hyperplasia | 1 1 1 | 7 1.4|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 1 | 1 1.0|
Pars Distalis, Angiectasis | 2 2 1 2 2 3 2 1 2 1 2 1 3| 26 1.8|
Pars Distalis, Cyst | X X | 2 |
Pars Distalis, Hemorrhage | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 1 2 2 2 1 2 2 2 | 16 1.9|
Pars Distalis, Pigmentation | 1 | 2 1.0|
Pars Nervosa, Cyst, Multiple | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 2 | 1 2.0|
C-Cell, Hyperplasia | 2 1 1 | 5 1.2|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + M M + + M + M + + + + + +| 41 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8| |
| 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
1.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Dilatation | | 1 3.0|
Hyperplasia | 2 | 2 2.0|
Inflammation, Chronic Active | 1 | 2 1.0|
Necrosis | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 3 |
__________________________________________________________________________|____________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 2 | 2 2.5|
Endometrium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mediastinal, Congestion | 2 | 1 2.0|
Mediastinal, Hemorrhage | 2 | 1 2.0|
Mediastinal, Pigmentation | 2 2 2 | 3 2.0|
Renal, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 |
Infiltration Cellular, Plasma Cell | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Congestion | 2 | 2 2.0|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 1| 41 1.9|
Necrosis | 2 | 1 2.0|
Pigmentation | 3 3 2 2 2 2 2 2 2 2 3 2 2 2 2| 38 2.2|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + + + + M + + + M + + M +| 44 |
Depletion Lymphoid | | 1 2.0|
Epithelial Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Galactocele | X X X X X X X X X X X X X X X X X| 32 |
Acinus, Hyperplasia | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8| |
| 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
1.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 2 2.0|
Edema | 2 | 2 2.5|
Hemorrhage | 1 | 5 1.0|
Infiltration Cellular, Histiocyte | 1 2 | 7 1.3|
Mineralization | | 1 2.0|
Necrosis | 1 | 1 1.0|
Goblet Cell, Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Cornea, Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Abscess | | 1 3.0|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + M + M M M + + + + M + M + + M + + + M M + + + +| 35 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
Nephropathy | 2 2 2 1 2 2 3 1 2 2 2 1 2 2 2 1 1 1 2 2 2 2 2 3| 49 1.9|
Cortex, Mineralization | 1 1 | 7 1.0|
Papilla, Mineralization | 1 1 | 4 1.0|
Pelvis, Mineralization | 1| 1 1.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 6| 9| 0| 3| 3| 0| 8| 8| 3| 3| 3| 3| 3| 3| 3| 3| 6| 8| |
| 6| 6| 6| 6| 3| 6| 5| 7| 6| 6| 6| 6| 1| 9| 0| 6| 6| 6| 6| 9| 6| 6| 6| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
1.25% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Pigmentation | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7|
| 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +|
Parasite | 1 1 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Parasite | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 1 |
Basophilic Focus | X X X X X X X X X X X X X |
Clear Cell Focus | X |
Congestion | |
Degeneration, Cystic | 1 1 |
Eosinophilic Focus | |
Fatty Change, Diffuse | 2 |
Fatty Change, Focal | 1 2 1 |
Focal Cellular Change | X |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | |
Hyperplasia | 2 2 |
Mixed Cell Focus | X X |
Necrosis | 2 |
Vacuolization Cytoplasmic | |
Bile Duct, Hyperplasia | 1 2 2 2 2 2 2 1 2 1 2 2 2 3 2 3 1 2 2 2 1 2 |
Oval Cell, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Mineralization | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Acinus, Hyperplasia | 1 |
Artery, Mineralization | 2 |
Artery, Necrosis, Fibrinoid | 2 1 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 1 |
Edema | |
Fibrosis | 2 |
Hyperkeratosis | 1 3 1 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7|
| 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 |
Necrosis | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A +|
Mineralization | 3 |
Necrosis | |
__________________________________________________________________________|
Tongue | |
Hyperkeratosis | |
__________________________________________________________________________|
Tooth | |
Gingiva, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 2 2 2 2 2 2 2 2 2 2 2 1 2 2|
Inflammation, Chronic Active | |
Artery, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 1 2 1 2 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M M + + + + M|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 3 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Hyperplasia | 1 2 2 1 2 2 |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + M + +|
Mineralization | 1 2 1|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + M + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7|
| 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 1 |
Necrosis | 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +|
Inflammation, Chronic Active | 2 2 2 2 2 |
Pigmentation | |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 1 1 1 1 1 2 1 1 1 1 1 1 2 2 |
Seminiferous Tubule, Atrophy | 2 2 2 1 1 1 2 2 3 2 2 1 2 2 2 2 2 2 3 2 2 |
Seminiferous Tubule, Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Congestion | 1 |
Lumbar, Infiltration Cellular, | |
Plasma Cell | 2 |
Mediastinal, Angiectasis | 2 2 |
Mediastinal, Pigmentation | 2 1 |
Pancreatic, Infiltration Cellular, | |
Plasma Cell | |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Erythrophagocytosis | |
Hemorrhage | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hemorrhage | 2 |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Depletion Lymphoid | 2 |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 1 1 1 1 2 3 1 1 1 1 2 2 2|
Necrosis | 2 |
Pigmentation | 2 2 2 1 |
__________________________________________________________________________|
Thymus | + + + M + + + M + + M M + + + + M + + + + + + +|
Depletion Lymphoid | 2 |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7|
| 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + M M + + + + M + M + + M + M M + + + M +|
Galactocele | X X |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + M + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | 4 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | |
Congestion | 1 2 3 |
Edema | 2 |
Embolus Tumor | |
Fibrosis | |
Hemorrhage | 1 1 1 |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + M +|
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cornea, Inflammation, Acute | 1 |
Lens, Cataract | 2 |
__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Inflammation, Granulomatous | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Nephropathy | 3 3 3 3 3 3 3 3 3 1 3 4 2 2 3 3 3 2 2 2 3 3 3 1 1|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 7| 6| 6| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 6| 3| 3| 3| 4| 8| 3| 0| 8| 6| 6| 3| 3| 4| 3| 2| 3| 1| 3| 7| 7|
| 7| 7| 7| 7| 0| 7| 7| 8| 1| 9| 8| 2| 1| 0| 0| 7| 7| 0| 2| 5| 8| 1| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cortex, Mineralization | 1 2 |
Papilla, Mineralization | 1 1 |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 1 |
Transitional Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + M + M + + + + + + + + + +|
Calculus Micro Observation Only | |
Artery, Necrosis, Fibrinoid | 1 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7| |
| 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + M + + + + + + + + M + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + M + + + + + + + + + + + + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + M + + + + + + + + + A + + + + A + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + M + + + + + + + + + + + + + + A + + + + +| 47 |
Parasite | 2 1 1 | 6 1.3|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + M + + + + + + + + + A + + + + A + + + + +| 46 |
Parasite | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + M + + + M + + + A + + + + + + A + + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 1| 5 1.4|
Basophilic Focus | X X X X X X X X X X X X| 25 |
Clear Cell Focus | X | 2 |
Congestion | 2 | 1 2.0|
Degeneration, Cystic | 1 | 3 1.0|
Eosinophilic Focus | X| 1 |
Fatty Change, Diffuse | 2 1 | 3 1.7|
Fatty Change, Focal | 1 2 1 1 | 7 1.3|
Focal Cellular Change | X | 2 |
Hepatodiaphragmatic Nodule | X | 4 |
Hyperplasia, Focal | 2 | 1 2.0|
Hyperplasia | 2 | 3 2.0|
Mixed Cell Focus | X X | 4 |
Necrosis | 1 2 | 3 1.7|
Vacuolization Cytoplasmic | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1| 39 1.9|
Oval Cell, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Fat, Mineralization | 1 2 | 2 1.5|
Fat, Necrosis | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 1 | 1 1.0|
Acinus, Hyperplasia | 2 2 | 3 1.7|
Artery, Mineralization | | 1 2.0|
Artery, Necrosis, Fibrinoid | 2 | 4 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + M + + + + + + + + + + + M + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7| |
| 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 | 3 1.7|
Edema | 2 | 1 2.0|
Fibrosis | | 1 2.0|
Hyperkeratosis | 1 | 4 1.5|
Inflammation, Chronic Active | 3 | 2 2.5|
Necrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Mineralization | | 1 3.0|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tongue | + + | 2 |
Hyperkeratosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Gingiva, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 2 1 1 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 1| 37 1.8|
Inflammation, Chronic Active | 1 | 1 1.0|
Artery, Mineralization | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 1 1 1 2 1 1 3 2 1| 25 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + M M M + M + + M + + + M +| 40 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 1 2 2 1 2 2 2 | 12 1.9|
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
Pars Distalis, Hyperplasia | 2 2 2 1 | 10 1.7|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 | 4 1.3|
Follicular Cell, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7| |
| 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + + + | 9 |
__________________________________________________________________________|____________|
Epididymis | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Mineralization | 1 | 4 1.3|
__________________________________________________________________________|____________|
Preputial Gland | + + + + M M + + + + + + + + + + + + + + + + + + +| 46 |
Dilatation | 3 | 1 3.0|
Inflammation, Chronic Active | 2 | 2 1.5|
Necrosis | 2 1 3 2 2 2 | 7 1.9|
__________________________________________________________________________|____________|
Prostate | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 2 3 1 3 2 1 2 | 12 2.0|
Pigmentation | 2 | 1 2.0|
Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 | 3 1.3|
__________________________________________________________________________|____________|
Testes | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Interstitial Cell, Hyperplasia | 1 2 2 2 1 1 1 1 2 1 1 1 2 | 28 1.3|
Seminiferous Tubule, Atrophy | 2 2 2 2 1 2 1 1 1 2 1 1 1 2 2 2 2 2 2 2 2 2| 43 1.8|
Seminiferous Tubule, Mineralization | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node | + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Lumbar, Congestion | | 1 1.0|
Lumbar, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Mediastinal, Angiectasis | | 2 2.0|
Mediastinal, Pigmentation | 2 | 3 1.7|
Pancreatic, Infiltration Cellular, | | |
Plasma Cell | 1 | 1 1.0|
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + M + + + + + + +| 46 |
Cyst | X X X | 4 |
Erythrophagocytosis | 2 | 1 2.0|
Hemorrhage | 2 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + A + + + +| 47 |
Degeneration, Cystic | 2 | 1 2.0|
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7| |
| 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Infiltration Cellular, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 |
Congestion | 2 | 2 2.0|
Depletion Lymphoid | | 1 2.0|
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 1 2 2 2 1 1 2 1 2 2 2 2 1 | 26 1.5|
Necrosis | | 1 2.0|
Pigmentation | 1 2 | 6 1.7|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + M + + + + M M + + + A M + M + +| 36 |
Depletion Lymphoid | 2 2 | 3 2.0|
Epithelial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + M + + + M + + + + + + + + + + M + + + + +| 37 |
Galactocele | X X | 4 |
Acinus, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Acanthosis | 2 2 2 | 3 2.0|
Hyperkeratosis | 4 4 3| 4 3.8|
Necrosis | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Atelectasis | 2 | 1 2.0|
Congestion | 2 2 3 2 2 2 2| 10 2.1|
Edema | 1 2 | 3 1.7|
Embolus Tumor | X | 1 |
Fibrosis | 2 | 1 2.0|
Hemorrhage | 1 2 1 | 6 1.2|
Infiltration Cellular, Histiocyte | 3 3 1 | 4 2.0|
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 1| 9| 4| 3| 1| 2| 6| 3| 3| 3| 4| 4| 1| 3| 3| 3| 1| 7| |
| 7| 7| 7| 7| 3| 7| 1| 1| 5| 1| 7| 1| 9| 4| 4| 7| 8| 6| 1| 5| 7| 8| 8| 8| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + M + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Acute | 2 | 2 2.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Cornea, Inflammation, Acute | | 1 1.0|
Lens, Cataract | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X X X | 6 |
Inflammation, Granulomatous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X X X | 4 |
Nephropathy | 3 2 3 3 3 3 2 3 2 3 2 2 1 1 3 3 2 2 1 3 3 3 2 3| 49 2.5|
Cortex, Mineralization | 1 1 1 | 5 1.2|
Papilla, Mineralization | 1 1 | 4 1.0|
Renal Tubule, Necrosis | 1 | 1 1.0|
Renal Tubule, Pigmentation | 1 1 | 3 1.0|
Transitional Epithelium, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + M + + + + +| 46 |
Calculus Micro Observation Only | X | 1 |
Artery, Necrosis, Fibrinoid | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 1| 9| 4| 3| 3| 3| 3| 2| 3| 3| 1| 3| 6|
| 6| 6| 6| 1| 2| 6| 6| 6| 6| 0| 6| 6| 6| 5| 0| 7| 6| 6| 5| 3| 7| 0| 1| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + +|
Parasite | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + M|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 2 2 |
Basophilic Focus | X X X X X X X X X |
Clear Cell Focus | X X X |
Degeneration, Cystic | 1 |
Developmental Malformation | X |
Eosinophilic Focus | X |
Fatty Change, Diffuse | |
Fatty Change, Focal | 2 2|
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | |
Hyperplasia | 2 |
Hyperplasia, Multifocal | |
Inflammation, Granulomatous | |
Mixed Cell Focus | X X X X X X X |
Necrosis | |
Pigmentation | |
Thrombosis | 2 2 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
Acinus, Hyperplasia, Focal | |
Acinus, Hyperplasia | 2 2 |
Artery, Hemorrhage | |
Artery, Inflammation, Chronic Active | |
Artery, Necrosis, Fibrinoid | 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + +|
Acanthosis | 2 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 1| 9| 4| 3| 3| 3| 3| 2| 3| 3| 1| 3| 6|
| 6| 6| 6| 1| 2| 6| 6| 6| 6| 0| 6| 6| 6| 5| 0| 7| 6| 6| 5| 3| 7| 0| 1| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + +|
Erosion | 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 2 |
Necrosis | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2|
Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + +|
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Focal | |
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 2 2 2 |
Pars Distalis, Hyperplasia | 2 2|
Pars Intermedia, Hyperplasia | 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + +|
Inflammation, Acute | |
Necrosis | |
__________________________________________________________________________|
Prostate | + + + + + + + + +|
Inflammation, Chronic Active | 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 1 2 1 2 1 1 1 2|
Seminiferous Tubule, Atrophy | 3 3 2 2 3 2 3 3 3 2 2 2 3 4 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 1| 9| 4| 3| 3| 3| 3| 2| 3| 3| 1| 3| 6|
| 6| 6| 6| 1| 2| 6| 6| 6| 6| 0| 6| 6| 6| 5| 0| 7| 6| 6| 5| 3| 7| 0| 1| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Axillary, Infiltration Cellular, | |
Plasma Cell | |
Inguinal, Infiltration Cellular, | |
Plasma Cell | |
Lumbar, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Angiectasis | 2 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Pigmentation | |
Pancreatic, Angiectasis | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Renal, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + +|
Angiectasis | 2 |
Degeneration, Cystic | |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + +|
Angiectasis | 2 |
Hemorrhage | 3 |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Fibrosis | 2 3 |
Hematopoietic Cell Proliferation | 1 2 2 2 2 1 |
Hemorrhage | 1 |
Mineralization | |
Necrosis | |
Pigmentation | 3 |
Thrombosis | |
__________________________________________________________________________|
Thymus | + M M + M + + + + + +|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + +|
Acanthosis | 2 2 |
Cyst Epithelial Inclusion | |
Hyperkeratosis | 3 4 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 4| 2| 3| 3| 3| 3| 4| 3| 3| 1| 9| 4| 3| 3| 3| 3| 2| 3| 3| 1| 3| 6|
| 6| 6| 6| 1| 2| 6| 6| 6| 6| 0| 6| 6| 6| 5| 0| 7| 6| 6| 5| 3| 7| 0| 1| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2.5% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + +|
Atelectasis | 2|
Congestion | 2 2 2 2 2 |
Edema | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + + |
Lens, Cataract | 2 3 |
__________________________________________________________________________|
Harderian Gland | + + + |
__________________________________________________________________________|
Zymbal's Gland | M + + + + + + + + + M + + + + + M + + + + + + + +|
Cyst | |
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | |
Necrosis | |
Nephropathy | 3 3 3 2 3 3 3 3 3 2 3 3 3 2 2 2 3 4 2 2 3 2 3 2 2|
Papilla, Mineralization | |
Renal Tubule, Hyperplasia | 1 1 |
Renal Tubule, Pigmentation | |
Transitional Epithelium, Hyperplasia | 1 2 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X X|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6| |
| 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + M + +| 14 |
__________________________________________________________________________|____________|
Intestine Large | + + + +| 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + +| 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + +| 10 |
Parasite | 1| 2 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + +| 9 |
__________________________________________________________________________|____________|
Intestine Small | + A + +| 9 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + +| 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A| 7 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + +| 9 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 1 | 7 1.7|
Basophilic Focus | X X X X X X X X X X| 19 |
Clear Cell Focus | X | 4 |
Degeneration, Cystic | 1 1 2 2 1 | 6 1.3|
Developmental Malformation | X | 2 |
Eosinophilic Focus | | 1 |
Fatty Change, Diffuse | 2 | 1 2.0|
Fatty Change, Focal | 1 1 | 4 1.5|
Hepatodiaphragmatic Nodule | | 1 |
Hyperplasia, Focal | 2 | 1 2.0|
Hyperplasia | 2 | 2 2.0|
Hyperplasia, Multifocal | 2 | 1 2.0|
Inflammation, Granulomatous | 1 | 1 1.0|
Mixed Cell Focus | X X | 9 |
Necrosis | 2 | 1 2.0|
Pigmentation | 3 | 1 3.0|
Thrombosis | | 2 2.0|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 31 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Acinus, Atrophy | 3 | 2 2.5|
Acinus, Hyperplasia, Focal | 1 | 1 1.0|
Acinus, Hyperplasia | 2 2 2 2 | 6 2.0|
Artery, Hemorrhage | 2 | 1 2.0|
Artery, Inflammation, Chronic Active | 1 3 | 2 2.0|
Artery, Necrosis, Fibrinoid | | 2 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + +| 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6| |
| 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + +| 18 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + +| 14 |
Acanthosis | 3 2 2 | 4 2.3|
Inflammation, Chronic | 3 | 2 2.5|
Ulcer | 4 | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + +| 15 |
Erosion | 2 2 | 3 2.0|
Infiltration Cellular, Lymphocyte | 3 2 | 2 2.5|
Inflammation, Chronic | 2 | 2 2.0|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + +| 15 |
Cardiomyopathy | 2 2 2 2 2 2| 13 2.0|
Thrombosis | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + +| 18 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + +| 18 |
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + +| 18 |
Hyperplasia | | 5 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + +| 45 |
Hyperplasia, Focal | 2 | 1 2.0|
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + M + M| 9 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + +| 20 |
Pars Distalis, Angiectasis | 2 2 2 2 2 1| 11 2.0|
Pars Distalis, Hyperplasia | 2 | 3 2.0|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + +| 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6| |
| 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + M + + +| 22 |
Inflammation, Acute | 2 3 | 2 2.5|
Necrosis | 2| 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + +| 13 |
Inflammation, Chronic Active | 2 | 3 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + +| 23 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 1 2 2 2 2 2 1 1 1 2 2 2 2| 23 1.6|
Seminiferous Tubule, Atrophy | 2 2 3 2 2 3 3 2 3 2 4 2 2 2 2 2 | 32 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + +| 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + +| 30 |
Axillary, Infiltration Cellular, | | |
Plasma Cell | 2 | 1 2.0|
Inguinal, Infiltration Cellular, | | |
Plasma Cell | 2 | 1 2.0|
Lumbar, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
Mediastinal, Angiectasis | | 2 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
Mediastinal, Pigmentation | 2 | 1 2.0|
Pancreatic, Angiectasis | 2 | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 2 2 2 | 3 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + +| 20 |
Angiectasis | | 1 2.0|
Degeneration, Cystic | 2 | 1 2.0|
Infiltration Cellular, Plasma Cell | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + +| 15 |
Angiectasis | | 1 2.0|
Hemorrhage | | 1 3.0|
Infiltration Cellular, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + +| 36 |
Depletion Lymphoid | | 1 2.0|
Fibrosis | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6| |
| 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2| 14 1.9|
Hemorrhage | 2 3 3 | 4 2.3|
Mineralization | 1 | 1 1.0|
Necrosis | 2 | 1 2.0|
Pigmentation | 2 | 2 2.5|
Thrombosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + +| 17 |
Depletion Lymphoid | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M| 9 |
__________________________________________________________________________|____________|
Skin | + + + + + + +| 18 |
Acanthosis | 2 2 | 4 2.0|
Cyst Epithelial Inclusion | X X | 2 |
Hyperkeratosis | 4 4 | 4 3.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + +| 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | +| 1 |
Hemorrhage | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + +| 28 |
Atelectasis | | 1 2.0|
Congestion | 2 2 3 3 2 | 10 2.2|
Edema | 1 | 1 1.0|
Hemorrhage | 1 1 | 2 1.0|
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + +| 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + +| 27 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + + +| 9 |
Lens, Cataract | 2 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 3| 4| 3| 7| 3| 3| 9| 7| 5| 3| 3| 3| 3| 2| 3| 3| 3| 1| 0| 3| 3| 3| 7| 6| |
| 7| 7| 5| 7| 4| 7| 7| 6| 2| 8| 7| 7| 7| 7| 6| 7| 7| 7| 8| 1| 7| 7| 7| 4| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
2.5% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + +| 7 |
__________________________________________________________________________|____________|
Zymbal's Gland | M + + + + + + + + + + + + + + M + + + + + + + + +| 45 |
Cyst | X | 1 |
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Cyst | X | 1 |
Necrosis | 2 | 1 2.0|
Nephropathy | 2 2 3 3 2 3 3 3 3 2 2 3 3 3 2 3 4 3 1 3 3 2 2 1| 49 2.6|
Papilla, Mineralization | 1 | 1 1.0|
Renal Tubule, Hyperplasia | 1 | 3 1.0|
Renal Tubule, Pigmentation | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia | 1 1 1 1 | 8 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A| 10 |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4|
| 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +|
Parasite | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Parasite | 1 2 |
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 1 |
Basophilic Focus | X X X X X X X X X X X X X X X |
Clear Cell Focus | X X |
Congestion | 1 |
Degeneration, Cystic | 1 1 1 2 1|
Developmental Malformation | |
Fatty Change, Diffuse | 2 |
Fatty Change, Focal | 2 |
Focal Cellular Change | X X X |
Hemorrhage | |
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | |
Inflammation | |
Mixed Cell Focus | X |
Necrosis | 2 |
Bile Duct, Hyperplasia | 1 1 1 2 2 2 2 1 1 2 2 2 2 2 2 2 2 1|
__________________________________________________________________________|
Mesentery | + + + + + + + |
Hemorrhage | 3 |
Fat, Mineralization | 1 |
Fat, Necrosis | 2 3 3 3 |
Fat, Pigmentation | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + M + + + + + + + + + + + + + M + + + + + +|
Fibrosis | |
Acinus, Hyperplasia, Focal | 1 |
Acinus, Hyperplasia | 1 |
Artery, Necrosis, Fibrinoid | 3 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Pharynx | |
Palate, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4|
| 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Edema | |
Hyperkeratosis | 1 2 2 1 |
Hyperplasia, Basal Cell | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 |
Hyperplasia | 2 2 |
Infiltration Cellular, Lymphocyte | 3 |
Mineralization | 2 |
Necrosis | |
Pigmentation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 2 2 1 2 2 1 2 3 2 1 1 2 2 2 2 2 2 2 2 2 2|
Inflammation, Acute | 2 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia | 1 |
Vacuolization Cytoplasmic, Diffuse | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 1 2 2 1 1 1 1 2 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + M + M + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 2 |
Pars Distalis, Hyperplasia | 2 2 1 1 1 2 1 2 1 2 2|
Pars Intermedia, Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4|
| 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Hyperplasia | 3 |
Inflammation, Chronic Active | 1 1 |
Necrosis | 3 3 3 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 3 2|
Inflammation | |
Mineralization | 1 |
Necrosis | 2 |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 1 1 2 1 1 1 1 1 1 2|
Seminiferous Tubule, Atrophy | 1 2 1 1 1 1 2 2 2 2 2 2 2 2 2 2 2 2 1|
Seminiferous Tubule, Mineralization | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Pigmentation | 2 |
Mediastinal, Congestion | |
Mediastinal, Depletion Lymphoid | 3 |
Mediastinal, Pigmentation | 2 |
Pancreatic, Cyst | X |
Pancreatic, Depletion Lymphoid | 2 |
Pancreatic, Hematocyst | X |
Pancreatic, Hemorrhage | |
Pancreatic, Infiltration Cellular, | |
Plasma Cell | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Renal, Infiltration Cellular, | |
Histiocyte | 2 |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Degeneration, Cystic | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Degeneration, Cystic | 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4|
| 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Depletion Lymphoid | |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 1 1 1 2 1 1 2 3 2 1 2 3 2 2 1 2 |
Pigmentation | 2 1 2 1 1 2 1 |
__________________________________________________________________________|
Thymus | + + M + M + + + + + + + + + + + + + + + + M +|
Depletion Lymphoid | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M M + M + + M + + + + M M + + + M + + + + M|
Galactocele | X X |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 |
Erosion | |
Hemorrhage | |
Hyperkeratosis | 3 4 |
Inflammation, Chronic Active | |
Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tarsal, Hyperostosis | 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 1 1 2 2 2 |
Edema | 2 |
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Inflammation, Acute | 2 2 2 2 1 |
Inflammation, Chronic Active | |
Metaplasia, Osseous | 2 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 2| 6| 3| 2| 8| 7| 6| 3| 3| 3| 1| 8| 3| 8| 0| 0| 6| 3| 3| 3| 8| 4|
| 5| 5| 5| 2| 0| 5| 5| 0| 4| 2| 5| 5| 5| 1| 1| 5| 9| 9| 3| 9| 5| 5| 5| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
5.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis | 1 |
Hydronephrosis | 1 4 |
Nephropathy | 3 3 3 3 2 2 2 3 3 2 3 3 3 3 3 3 3 3 2 3 4 3 2 3|
Capsule, Fibrosis | |
Cortex, Mineralization | 1 2 1 1 1 |
Papilla, Mineralization | 1 1 1 1 1 1 |
Renal Tubule, Dilatation | 3 |
Renal Tubule, Necrosis | 1 |
Renal Tubule, Pigmentation | 2 1 |
Transitional Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
Fibrosis | 1 |
Hemorrhage | 2 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| |
| 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite | 2 2 1 1 1 2 1 | 14 1.2|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + M + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + A| 47 |
Lymphoid Tissue, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + A + + + + + + + + + + + + + + + + A| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 3 2 1 1 | 8 1.6|
Basophilic Focus | X X X X X X X X X X | 25 |
Clear Cell Focus | X | 3 |
Congestion | | 1 1.0|
Degeneration, Cystic | 2 | 6 1.3|
Developmental Malformation | X | 1 |
Fatty Change, Diffuse | | 1 2.0|
Fatty Change, Focal | 2 1 1 1 | 5 1.4|
Focal Cellular Change | X X X X X | 8 |
Hemorrhage | 4 1 | 2 2.5|
Hyperplasia, Focal | 2 3 4 3 | 5 2.8|
Hyperplasia, Multifocal | 2 | 1 2.0|
Inflammation | 1 | 1 1.0|
Mixed Cell Focus | X X | 3 |
Necrosis | 3 1 3| 4 2.3|
Bile Duct, Hyperplasia | 2 1 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 | 35 1.8|
__________________________________________________________________________|____________|
Mesentery | + + | 9 |
Hemorrhage | | 1 3.0|
Fat, Mineralization | | 1 1.0|
Fat, Necrosis | 2 4 | 6 2.8|
Fat, Pigmentation | 3 | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Fibrosis | 2 | 1 2.0|
Acinus, Hyperplasia, Focal | | 1 1.0|
Acinus, Hyperplasia | 2 | 2 1.5|
Artery, Necrosis, Fibrinoid | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| |
| 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Duct, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | +| 1 |
Palate, Epithelium, Hyperplasia | 4| 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acanthosis | 2 | 2 1.5|
Edema | 2 | 1 2.0|
Hyperkeratosis | 2 2 2 | 7 1.7|
Hyperplasia, Basal Cell | | 1 3.0|
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
Degeneration | | 1 1.0|
Hyperplasia | 1 | 3 1.7|
Infiltration Cellular, Lymphocyte | 2 | 2 2.5|
Mineralization | 1 | 2 1.5|
Necrosis | 2 | 1 2.0|
Pigmentation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 47 1.9|
Inflammation, Acute | | 1 2.0|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Hemorrhage | | 1 2.0|
Hyperplasia | 1 | 2 1.0|
Vacuolization Cytoplasmic, Diffuse | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Hyperplasia | 1 2 2 2 1 1 1 2| 21 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + + + + + + + + + M M + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 2 3 | 6 2.3|
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 1 2 2 | 21 1.7|
Pars Intermedia, Hyperplasia | | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| |
| 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 | 6 1.3|
Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + + + +| 6 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | | 1 2.0|
Hyperplasia | | 1 3.0|
Inflammation, Chronic Active | 1 | 3 1.0|
Necrosis | 1 2 | 7 2.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 3 2 2| 9 2.2|
Inflammation | 2 | 1 2.0|
Mineralization | | 1 1.0|
Necrosis | | 1 2.0|
Epithelium, Hyperplasia | 1 2 2 | 4 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 2 1 1 1 1 2 1 1 1 1 1 2 2 1 | 25 1.2|
Seminiferous Tubule, Atrophy | 2 2 2 3 2 2 2 2 2 2 2 1 2 2 2 2 2 1 3 1 2 3 2 3 2| 44 1.9|
Seminiferous Tubule, Mineralization | | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Reticulum Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumbar, Pigmentation | | 1 2.0|
Mediastinal, Congestion | 2 | 1 2.0|
Mediastinal, Depletion Lymphoid | | 1 3.0|
Mediastinal, Pigmentation | 2 | 2 2.0|
Pancreatic, Cyst | | 1 |
Pancreatic, Depletion Lymphoid | | 1 2.0|
Pancreatic, Hematocyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| |
| 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Hemorrhage | 2| 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 1 | 1 1.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Renal, Pigmentation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X | 2 |
Degeneration, Cystic | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | | 1 2.0|
Degeneration, Cystic | 2 | 2 2.0|
Hemorrhage | 2| 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 2 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2| 1 2.0|
Depletion Lymphoid | 2 1 | 2 1.5|
Fibrosis | 2 3 | 2 2.5|
Hematopoietic Cell Proliferation | 2 2 1 2 2 2 1 1 1 1 1 | 28 1.6|
Pigmentation | 2 2 2 2 2 2 2 1 | 15 1.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Depletion Lymphoid | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M M + M + + + + + + + M + + + + + + + + + +| 38 |
Galactocele | X X X X | 6 |
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 3 | 4 2.5|
Erosion | 4 | 1 4.0|
Hemorrhage | 3 | 1 3.0|
Hyperkeratosis | 3 3 3 | 5 3.2|
Inflammation, Chronic Active | 2 | 1 2.0|
Necrosis | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| |
| 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Tarsal, Hyperostosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 1 2 2 2 2 | 11 1.7|
Edema | 2 | 2 2.0|
Hemorrhage | 1 1 1 1 | 6 1.0|
Infiltration Cellular, Histiocyte | 3 1 1 | 11 1.2|
Inflammation, Chronic Active | 2 2 1 2 | 5 1.6|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
Inflammation, Acute | 2 2 2 | 8 1.9|
Inflammation, Chronic Active | 1 | 1 1.0|
Metaplasia, Osseous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 3 |
__________________________________________________________________________|____________|
Eye | + + + | 6 |
Lens, Cataract | 2 | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 4 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + M M M M M + M + + + + + + + + M + + + + + M +| 41 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Fibrosis | | 1 1.0|
Hydronephrosis | | 2 2.5|
Nephropathy | 3 2 3 3 1 3 3 1 2 3 3 3 3 3 2 2 3 3 2 2 3 2 2 2 3| 49 2.6|
Capsule, Fibrosis | 2 | 1 2.0|
Cortex, Mineralization | 2 1 | 7 1.3|
Papilla, Mineralization | 1 1 1| 9 1.0|
Renal Tubule, Dilatation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05023-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PENTAERYTHRITOL TETRANITRATE Date: 05/01/97
Route: DOSED FEED Time: 12:56:45
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| |
| 6| 5| 5| 5| 7| 6| 6| 9| 7| 8| 6| 6| 6| 1| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
5.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Necrosis | | 1 1.0|
Renal Tubule, Pigmentation | 2 1 1 | 5 1.4|
Transitional Epithelium, Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 1 |
Fibrosis | | 1 1.0|
Hemorrhage | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
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