TR 365 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Mason DATE: 09/04/94 EXP: 05023 PENTAERYTHRITOL TETRANITRATE TIME: 00:50:50 TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1 TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 55743 CONT: N01CP9561901 CAS: 78-11-5 PATHOLOGIST: K. MURTHY -------------------------------------------------------------------------------- REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Mason DATE: 09/04/94 EXP: 05023 PENTAERYTHRITOL TETRANITRATE TIME: 00:50:50 TEST: 01 CAGES FROM 0000 TO LAST CAGE TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 55743 CONT: N01CP9561901 CAS: 78-11-5 PATHOLOGIST: K. MURTHY PENTAERYTHRITOL TETRANITRATE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE RATS FIRST TERMINAL SACRIFICE AT 735 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = CONTROL | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 | | | | UNCENSORED DEATHS | | 413 479 534 564 577 589 615 625 629 632 | | 639 640 641 641 641 646 660 660 660 672 | | 681 695 702 711 711 711 718 731 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 2.5% | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 | | | | UNCENSORED DEATHS | | 326 501 562 564 622 630 640 640 641 645 | | 658 672 674 674 695 696 711 716 718 723 | | 730 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 5.0% | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 | | | | UNCENSORED DEATHS | | 560 562 589 622 641 648 669 674 680 681 | | 687 703 707 709 711 715 718 725 727 729 | | 731 | | CENSORED DEATHS | | NONE | | | ================================================================================== PENTAERYTHRITOL TETRANITRATE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE RATS FIRST TERMINAL SACRIFICE AT 735 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 735 (A) | | | |--------------------------------------------------------------------------------| | | | |CONTROL | 100.0 100.0 100.0 100.0 98.0 96.0 94.0 88.0 62.0 44.0 | | | | | | | |2.5% | 100.0 100.0 100.0 98.0 98.0 98.0 96.0 92.0 78.0 58.0 | | | | | | | |5.0% | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 94.0 88.0 58.0 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | CONTROL 2.5% 5.0% | | | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 44.0% 58.0% 58.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.086N P=0.177N P=0.099N | |(LIFE TABLE) | | | | | |MEAN DAY OF | 636.3 639.9 675.6 | |NATURAL DEATHS (C) | (13.7) (20.2) (11.7) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 679.7 695.1 710.1 | |(STANDARD ERROR) | (10.3) (10.7) ( 6.4) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) PENTAERYTHRITOL TETRANITRATE STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE RATS FIRST TERMINAL SACRIFICE AT 735 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = CONTROL | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 | | | | UNCENSORED DEATHS | | 441 504 557 563 567 610 628 639 644 646 | | 647 660 682 710 718 722 723 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 0.62% | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 | | | | UNCENSORED DEATHS | | 200 443 547 568 585 585 586 639 639 641 | | 653 673 695 699 708 715 722 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 1.25% | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 | | | | UNCENSORED DEATHS | | 441 442 506 508 589 596 634 639 662 667 | | 667 680 683 689 689 701 708 709 724 | | CENSORED DEATHS | | NONE | | | ================================================================================== PENTAERYTHRITOL TETRANITRATE STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE RATS FIRST TERMINAL SACRIFICE AT 735 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 735 (A) | | | |--------------------------------------------------------------------------------| | | | |CONTROL | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 90.0 76.0 66.0 | | | | | | | |0.62% | 100.0 100.0 98.0 98.0 98.0 96.0 96.0 86.0 78.0 66.0 | | | | | | | |1.25% | 100.0 100.0 100.0 100.0 100.0 96.0 92.0 88.0 82.0 62.0 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | CONTROL 0.62% 1.25% | | | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 66.0% 66.0% 62.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.774 P=1.000 P=0.846 | |(LIFE TABLE) | | | | | |MEAN DAY OF | 627.1 605.8 628.1 | |NATURAL DEATHS (C) | (19.3) (30.9) (20.7) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 698.3 691.1 694.4 | |(STANDARD ERROR) | ( 9.7) (13.5) (10.7) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) PENTAERYTHRITOL TETRANITRATE KAPLAN-MEIER SURVIVAL CURVES CONTROL = 1 2.5% = 2 5.0% = 3 ------------------------------------------------------ SPECIES=RATS SEX=MALE ------------------------------------------------------- Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 2 1 3 | 2 1 1 2 33 | 1 2 1 1 3 3 | 1 1 2 3 P 90 + 1 1 22 33 E | 1 1 2 23 3 R | 1 1 333 C | 1122 E 80 + 1122 33 N | 2 2 3 3 T | 22 33 | 2 2 S 70 + 11 33 U | 1 1 2 2 R | 223 V | 11 22 3 I 60 + 1 1 2 2 V | 1 1 2 A | 111 L | 50 + | 11 | 1 1 | 40 + | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 14 obs hidden. PENTAERYTHRITOL TETRANITRATE KAPLAN-MEIER SURVIVAL CURVES CONTROL = 1 0.62% = 2 1.25% = 3 ----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------ Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 2 1 | | 2 12 1 | 96 + 2 13 21 | | 2112 | 92 + 3 2 2 3 | | 1 33 1 | P 88 + 3 1 13 E | R | 2 131 C | E 84 + 3 3 N | T | 11 33 | S 80 + 2 2 U | R | 12 1323 V | I 76 + 1 21 2 V | A | 13 1 L | 72 + 2 11 | | 3 3211 | 68 + 3322 | | 1 1 | 64 + 3 3 | | 3 3 | 60 + | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 13 obs hidden. --multipart-boundary Content-type: text/plain Range: bytes 24967-24967/24967 --multipart-boundary--