TR 371 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
TOLUENE
NTP Experiment-Test: 05701-03 Report: PEIRPT03
Study Type: CHRONIC Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:14
Facility: International Research and Development Corp.
Chemical CAS #: 108883
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Dead 11 6 13 9
Moribund 8 8 11 3
Accident 1 3 1
Natural Death 2 2
Survivors
Terminal Sacrifice 30 33 23 32
Dead 1
Missing 3
Animals Examined Microscopically 50 50 50 47
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (50) (50) (47)
Infiltration Cellular, Lymphocyte 2 (4%)
Inflammation, Acute 1 (2%)
Gallbladder (49) (49) (50) (45)
Hyperplasia, Lymphoid 2 (4%)
Infiltration Cellular, Lymphocyte 14 (29%) 18 (37%) 15 (30%) 16 (36%)
Inflammation, Acute 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Intestine Large (50) (50) (50) (47)
Anorectal Junction, Inflammation, Acute 1 (2%)
Anorectal Junction, Inflammation, Chronic
Active 1 (2%)
Anorectal Junction, Ulcer 1 (2%)
Anus, Erosion 1 (2%)
Anus, Inflammation, Acute 1 (2%) 1 (2%)
Anus, Inflammation, Chronic Active 1 (2%)
Anus, Ulcer 1 (2%)
Intestine Large, Cecum (49) (50) (50) (47)
Inflammation, Acute 1 (2%)
Intestine Large, Rectum (50) (50) (50) (45)
Inflammation, Acute 1 (2%) 1 (2%) 1 (2%)
Intestine Small, Duodenum (49) (50) (50) (47)
Inflammation, Chronic Active 1 (2%)
Intestine Small, Ileum (49) (50) (50) (47)
Amyloid Deposition 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Intestine Small, Jejunum (49) (50) (50) (47)
Diverticulum 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Necrosis 1 (2%)
Liver (49) (50) (50) (47)
Basophilic Focus 1 (2%) 3 (6%)
Bile Stasis 1 (2%)
Congestion 1 (2%)
Cyst 1 (2%)
Fatty Change 1 (2%) 1 (2%) 3 (6%)
Hematopoietic Cell Proliferation 23 (47%) 16 (32%) 30 (60%) 26 (55%)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Infarct 1 (2%)
Infiltration Cellular, Lymphocyte 23 (47%) 16 (32%) 15 (30%) 21 (45%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Necrosis 7 (14%) 4 (8%) 4 (8%) 4 (9%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Hepatocyte, Hypertrophy 1 (2%)
Median Lobe, Angiectasis 1 (2%)
Serosa, Inflammation, Chronic 1 (2%) 1 (2%)
Mesentery (5) (2) (4) (2)
Inflammation, Chronic 1 (25%)
Fat, Necrosis 1 (20%) 1 (25%)
Pancreas (50) (50) (50) (47)
Hyperplasia, Lymphoid 4 (8%) 1 (2%)
Infiltration Cellular, Lymphocyte 17 (34%) 28 (56%) 25 (50%) 26 (55%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Acinus, Atrophy 3 (6%) 1 (2%) 2 (4%) 2 (4%)
Duct, Cyst 1 (2%) 1 (2%)
Salivary Glands (50) (50) (50) (46)
Atrophy 1 (2%)
Hyperplasia, Lymphoid 4 (8%)
Infiltration Cellular, Lymphocyte 28 (56%) 37 (74%) 33 (66%) 32 (70%)
Stomach (50) (50) (50) (47)
Hyperplasia, Focal, Squamous 1 (2%)
Stomach, Forestomach (50) (49) (50) (47)
Angiectasis 1 (2%)
Erosion 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Hyperkeratosis 2 (4%)
Hyperplasia, Focal, Squamous 2 (4%) 3 (6%) 2 (4%) 2 (4%)
Hyperplasia, Squamous 2 (4%) 6 (12%) 4 (8%) 4 (9%)
Infiltration Cellular, Lymphocyte 5 (10%) 6 (12%) 8 (16%) 5 (11%)
Inflammation, Acute 2 (4%) 2 (4%) 6 (12%) 7 (15%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 4 (8%) 3 (6%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Ulcer 1 (2%) 1 (2%) 4 (8%) 4 (9%)
Stomach, Glandular (49) (50) (50) (47)
Edema 1 (2%)
Erosion 2 (4%) 4 (8%) 4 (8%) 2 (4%)
Hyperplasia, Lymphoid 2 (4%)
Infiltration Cellular, Lymphocyte 15 (31%) 18 (36%) 22 (44%) 23 (49%)
Inflammation, Acute 4 (8%) 2 (4%) 2 (4%) 2 (4%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Metaplasia, Squamous 1 (2%)
Mineralization 1 (2%) 2 (4%) 2 (4%)
Ulcer 2 (4%) 2 (4%)
Mucosa, Dilatation 10 (20%) 6 (12%) 10 (20%) 14 (30%)
Tooth (1)
Pulp, Inflammation, Acute 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (47)
Aorta, Mineralization 1 (2%)
Heart (50) (50) (50) (47)
Fibrosis, Focal 1 (2%)
Infiltration Cellular, Lymphocyte 10 (20%) 13 (26%) 20 (40%) 18 (38%)
Inflammation, Acute 3 (6%)
Inflammation, Chronic 2 (4%) 1 (2%) 4 (8%) 1 (2%)
Inflammation, Chronic Active 2 (4%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Atrium, Thrombosis 1 (2%)
Coronary Artery, Inflammation, Acute 1 (2%)
Coronary Artery, Inflammation, Chronic 1 (2%) 1 (2%)
Valve, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (50) (50) (47)
Capsule, Inflammation, Acute 1 (2%)
Capsule, Spindle Cell, Hyperplasia 49 (100%) 50 (100%) 49 (98%) 45 (96%)
Adrenal Gland, Cortex (49) (50) (50) (47)
Congestion 1 (2%)
Cyst 1 (2%) 1 (2%)
Degeneration, Fatty 1 (2%) 9 (18%) 2 (4%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 1 (2%)
Hypertrophy 1 (2%) 2 (4%) 2 (4%) 4 (9%)
Hypertrophy, Diffuse 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Necrosis 1 (2%)
Pigmentation 35 (71%) 37 (74%) 45 (90%) 37 (79%)
Thrombosis 1 (2%) 1 (2%)
Spindle Cell, Hyperplasia 1 (2%)
Adrenal Gland, Medulla (49) (50) (49) (47)
Hyperplasia 1 (2%) 1 (2%)
Necrosis 1 (2%)
Islets, Pancreatic (50) (49) (50) (47)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (49) (48) (49) (46)
Pars Distalis, Angiectasis 2 (4%) 2 (4%)
Pars Distalis, Cyst 3 (6%) 3 (6%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 12 (24%) 18 (38%) 14 (29%) 15 (33%)
Thyroid Gland (50) (50) (50) (47)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Lymphocyte 5 (10%) 6 (12%) 8 (16%) 6 (13%)
Inflammation, Acute 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%) 3 (6%)
C-Cell, Hyperplasia 1 (2%)
Follicle, Dilatation 8 (16%) 5 (10%) 4 (8%) 5 (11%)
Follicle, Hyperplasia 9 (18%) 13 (26%) 7 (14%) 10 (21%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (1) (1) (1) (1)
Abscess 1 (100%)
Cyst 1 (100%)
Ovary (50) (49) (50) (47)
Abscess 2 (4%)
Hemorrhage 1 (2%) 2 (4%)
Hyperplasia, Lymphoid 2 (4%)
Hyperplasia, Adenomatous 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Acute 2 (4%) 4 (9%)
Mineralization 1 (2%)
Pigmentation, Hemosiderin, Cholesterol 1 (2%)
Follicle, Cyst 1 (2%)
Follicle, Cyst Multilocular 1 (2%)
Periovarian Tissue, Cyst 11 (22%) 8 (16%) 8 (16%) 7 (15%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Oviduct (1)
Inflammation, Acute 1 (100%)
Uterus (50) (50) (50) (47)
Angiectasis 1 (2%) 2 (4%) 1 (2%)
Endometrium, Hyperplasia, Cystic 45 (90%) 43 (86%) 38 (76%) 38 (81%)
Endometrium, Inflammation, Acute 4 (8%) 1 (2%) 7 (14%) 6 (13%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (47)
Angiectasis 1 (2%)
Fibrosis 25 (50%) 32 (64%) 26 (52%) 21 (45%)
Fibrous Osteodystrophy 4 (9%)
Myeloid Cell, Hyperplasia 33 (66%) 35 (70%) 38 (76%) 34 (72%)
Lymph Node (48) (49) (50) (46)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%) 2 (4%)
Inflammation, Acute 1 (2%)
Axillary, Hyperplasia, Lymphoid 1 (2%)
Bronchial, Hyperplasia, Lymphoid 1 (2%)
Iliac, Hyperplasia, Lymphoid 3 (6%) 2 (4%)
Iliac, Inflammation, Acute 1 (2%)
Mediastinal, Congestion 2 (4%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%) 1 (2%) 2 (4%) 5 (11%)
Mediastinal, Inflammation, Acute 1 (2%)
Mesenteric, Angiectasis 1 (2%) 1 (2%)
Mesenteric, Congestion 5 (10%) 6 (12%) 7 (15%)
Mesenteric, Hemorrhage 1 (2%)
Mesenteric, Hyperplasia, Lymphoid 26 (54%) 17 (35%) 21 (42%) 24 (52%)
Mesenteric, Inflammation, Acute 1 (2%) 2 (4%) 7 (14%) 7 (15%)
Renal, Congestion 1 (2%)
Renal, Hyperplasia, Lymphoid 2 (4%) 1 (2%) 1 (2%)
Renal, Inflammation, Acute 1 (2%) 1 (2%)
Lymph Node, Mandibular (47) (48) (50) (43)
Congestion 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Hyperplasia, Glandular 1 (2%)
Hyperplasia, Lymphoid 31 (66%) 29 (60%) 32 (64%) 25 (58%)
Inflammation, Acute 2 (4%) 2 (4%) 1 (2%)
Pigmentation 1 (2%) 1 (2%)
Spleen (50) (50) (49) (47)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 41 (82%) 39 (78%) 41 (84%) 45 (96%)
Hyperplasia, Lymphoid 16 (32%) 16 (32%) 13 (27%) 14 (30%)
Infiltration Cellular 1 (2%)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Necrosis 1 (2%)
Pigmentation 37 (74%) 33 (66%) 34 (69%) 28 (60%)
Capsule, Inflammation, Acute 1 (2%)
Thymus (46) (48) (48) (47)
Congestion 1 (2%) 1 (2%)
Cyst 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Ectopic Thyroid 1 (2%)
Edema 1 (2%)
Hyperplasia, Lymphoid 7 (15%) 6 (13%) 10 (21%) 10 (21%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (48) (46)
Ectasia 16 (33%) 18 (36%) 18 (38%) 11 (24%)
Inflammation, Acute 1 (2%)
Acinus, Ectasia 1 (2%)
Skin (50) (50) (50) (47)
Alopecia 9 (18%) 9 (18%) 8 (16%) 2 (4%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Ulcer 1 (2%)
Back, Ulcer 1 (2%)
Foot, Ulcer 1 (2%)
Head, Ulcer 1 (2%) 1 (2%)
Inguinal, Inflammation, Acute 1 (2%)
Inguinal, Ulcer 1 (2%)
Subcutaneous Tissue, Edema 1 (2%) 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation, Acute 1 (2%) 1 (2%)
Ventral, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (49) (50) (47)
Cranium, Fracture 1 (2%)
Cranium, Inflammation, Chronic Active 1 (2%)
Femur, Fracture 1 (2%) 1 (2%) 1 (2%)
Skeletal Muscle (1) (2)
Head, Inflammation, Acute 2 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (47)
Compression 3 (6%) 1 (2%)
Hemorrhage 5 (10%) 4 (8%) 2 (4%)
Infiltration Cellular, Lymphocyte 4 (8%) 3 (6%) 4 (8%) 3 (6%)
Mineralization 35 (70%) 31 (62%) 30 (60%) 28 (60%)
Hippocampus, Cyst 1 (2%)
Meninges, Inflammation, Acute 1 (2%) 1 (2%)
Nerve, Inflammation, Acute 1 (2%)
Ventricle, Dilatation 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (47)
Congestion 13 (26%) 2 (4%) 9 (18%) 8 (17%)
Hemorrhage 5 (10%) 8 (16%) 7 (14%) 6 (13%)
Hyperplasia, Lymphoid 5 (10%) 1 (2%)
Infiltration Cellular, Lymphocyte 30 (60%) 42 (84%) 40 (80%) 43 (91%)
Mineralization 2 (4%) 7 (14%) 1 (2%)
Pigmentation, Cholesterol 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 3 (6%) 3 (6%) 4 (9%)
Alveolus, Infiltration Cellular, Histiocyte 2 (4%) 2 (4%) 3 (6%) 7 (15%)
Interstitium, Inflammation, Acute 3 (6%) 1 (2%) 1 (2%)
Interstitium, Inflammation, Chronic 1 (2%) 1 (2%)
Peribronchiolar, Inflammation, Acute 1 (2%) 1 (2%)
Pleura, Inflammation, Chronic 1 (2%) 1 (2%)
Pleura, Interstitium, Inflammation, Acute 1 (2%)
Nose (50) (50) (50) (47)
Lumen, Hemorrhage 31 (62%) 28 (56%) 28 (56%) 25 (53%)
Mucosa, Inflammation, Acute 3 (6%) 1 (2%) 4 (8%) 6 (13%)
Nasolacrimal Duct, Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Acute 1 (2%) 5 (10%) 2 (4%)
Olfactory Epithelium, Degeneration 48 (96%) 31 (62%) 41 (82%) 31 (66%)
Olfactory Epithelium, Inflammation, Acute 1 (2%) 3 (6%)
Olfactory Epithelium, Metaplasia 3 (6%)
Respiratory Epithelium, Degeneration 18 (36%) 19 (38%) 14 (28%) 12 (26%)
Respiratory Epithelium, Inflammation, Acute 2 (4%)
Turbinate, Inflammation, Acute 1 (2%) 1 (2%) 1 (2%)
Vomeronasal Organ, Inflammation, Acute 1 (2%)
Trachea (50) (50) (50) (47)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (2%)
Glands, Inflammation, Acute 1 (2%)
Lumen, Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Atrophy 1 (100%)
Harderian Gland (3) (2) (3)
Hyperplasia 1 (33%)
Infiltration Cellular, Lymphocyte 1 (33%)
Inflammation, Acute 1 (33%)
Inflammation, Chronic Active 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (47)
Abscess 1 (2%) 1 (2%)
Congestion 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 6 (12%) 1 (2%)
Infarct 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 31 (62%) 42 (84%) 36 (72%) 38 (81%)
Inflammation 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Metaplasia, Osseous 4 (8%) 1 (2%) 3 (6%) 4 (9%)
Mineralization 1 (2%)
Regeneration 1 (2%)
Capsule, Inflammation, Chronic 1 (2%)
Pelvis, Dilatation 2 (4%) 1 (2%) 1 (2%)
Pelvis, Inflammation, Acute 2 (4%)
Renal Tubule, Casts Protein 6 (12%) 11 (22%) 5 (10%) 12 (26%)
Renal Tubule, Dilatation 24 (48%) 16 (32%) 30 (60%) 24 (51%)
Renal Tubule, Necrosis 5 (10%) 7 (14%) 9 (18%) 6 (13%)
Renal Tubule, Pigmentation 1 (2%) 1 (2%) 1 (2%)
Renal Tubule, Regeneration 14 (28%) 13 (26%) 23 (46%) 15 (32%)
Ureter (1) (1)
Dilatation 1 (100%) 1 (100%)
Infiltration Cellular, Lymphocyte 1 (100%)
Urinary Bladder (50) (50) (50) (47)
Angiectasis 1 (2%) 1 (2%)
Ectasia 2 (4%)
Hyperplasia, Lymphoid 5 (10%) 1 (2%)
Infiltration Cellular, Lymphocyte 31 (62%) 39 (78%) 34 (68%) 35 (74%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Early Deaths
Moribund 19 18 23 17
Dead 23 19 16 21
Accident 1 2 2
Natural Death 1 3 1
Survivors
Terminal Sacrifice 17 21 16 19
Dead 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (59) (60) (60) (57)
Inflammation, Chronic 1 (2%)
Gallbladder (59) (54) (57) (59)
Cyst 1 (2%)
Infiltration Cellular, Lymphocyte 6 (10%) 8 (15%) 8 (14%) 7 (12%)
Inflammation, Acute 1 (2%) 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Intestine Large (60) (60) (60) (60)
Anorectal Junction, Erosion 1 (2%) 1 (2%)
Anorectal Junction, Inflammation, Acute 1 (2%)
Anus, Erosion 2 (3%) 1 (2%)
Anus, Inflammation, Acute 1 (2%)
Anus, Inflammation, Chronic Active 1 (2%) 1 (2%)
Anus, Ulcer 2 (3%) 2 (3%) 3 (5%)
Intestine Large, Cecum (60) (60) (60) (59)
Parasite Metazoan 2 (3%) 3 (5%)
Intestine Large, Colon (60) (60) (60) (59)
Parasite Metazoan 1 (2%) 1 (2%) 1 (2%) 2 (3%)
Intestine Large, Rectum (59) (59) (60) (58)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Ulcer 4 (7%) 2 (3%) 1 (2%)
Anorectal Junction, Ulcer 1 (2%)
Intestine Small, Ileum (60) (60) (60) (60)
Amyloid Deposition 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Intestine Small, Jejunum (60) (60) (60) (60)
Hyperplasia, Lymphoid 1 (2%)
Liver (60) (60) (60) (59)
Basophilic Focus 2 (3%) 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Bile Stasis 1 (2%)
Cyst 1 (2%) 1 (2%)
Focal Cellular Change 1 (2%)
Hematopoietic Cell Proliferation 21 (35%) 13 (22%) 17 (28%) 17 (29%)
Hyperplasia 1 (2%) 2 (3%)
Hypertrophy 1 (2%)
Infarct 1 (2%) 1 (2%) 1 (2%) 2 (3%)
Infiltration Cellular, Lymphocyte 2 (3%) 7 (12%) 10 (17%) 3 (5%)
Inflammation, Acute 3 (5%) 1 (2%) 2 (3%) 2 (3%)
Inflammation, Chronic 3 (5%) 1 (2%) 1 (2%)
Necrosis 5 (8%) 6 (10%) 4 (7%) 9 (15%)
Bile Duct, Hyperplasia 1 (2%)
Caudate Lobe, Infarct 1 (2%)
Centrilobular, Fatty Change 1 (2%)
Periportal, Inflammation, Chronic 2 (3%)
Serosa, Inflammation, Chronic 1 (2%)
Mesentery (2) (2) (1)
Artery, Inflammation, Chronic 1 (50%)
Artery, Inflammation, Chronic Active 1 (50%)
Pancreas (60) (60) (60) (59)
Cyst 1 (2%)
Fibrosis 1 (2%)
Infiltration Cellular, Lymphocyte 11 (18%) 14 (23%) 18 (30%) 14 (24%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Acinus, Atrophy 1 (2%) 3 (5%) 1 (2%)
Acinus, Hyperplasia 1 (2%) 1 (2%)
Salivary Glands (60) (60) (60) (59)
Hemorrhage 1 (2%)
Hyperplasia, Glandular 1 (2%)
Infiltration Cellular 1 (2%)
Infiltration Cellular, Lymphocyte 30 (50%) 36 (60%) 34 (57%) 30 (51%)
Mineralization 1 (2%)
Stomach, Forestomach (60) (59) (60) (60)
Erosion 1 (2%)
Hyperkeratosis 1 (2%) 1 (2%)
Hyperplasia, Focal, Squamous 1 (2%)
Hyperplasia, Squamous 7 (12%) 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%) 3 (5%) 1 (2%) 1 (2%)
Inflammation, Acute 4 (7%) 2 (3%) 2 (3%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 2 (3%) 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
Stomach, Glandular (60) (60) (60) (60)
Edema 2 (3%)
Erosion 4 (7%) 6 (10%) 6 (10%) 4 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Infiltration Cellular, Lymphocyte 14 (23%) 14 (23%) 17 (28%) 15 (25%)
Inflammation, Acute 2 (3%) 2 (3%) 3 (5%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mucosa, Dilatation 2 (3%) 6 (10%) 5 (8%) 13 (22%)
Mucosa, Hyperplasia 1 (2%)
Submucosa, Edema 1 (2%)
Tooth (2) (8) (2) (1)
Peridontal Tissue, Inflammation, Chronic
Active 2 (25%)
Pulp, Inflammation, Acute 2 (100%) 2 (25%) 2 (100%)
Pulp, Inflammation, Chronic 1 (13%)
Pulp, Inflammation, Chronic Active 3 (38%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (59) (60) (60) (60)
Aorta, Inflammation, Chronic 1 (2%)
Aorta, Mineralization 1 (2%) 1 (2%)
Heart (60) (60) (60) (59)
Atrophy 1 (2%)
Infiltration Cellular, Lymphocyte 9 (15%) 13 (22%) 9 (15%) 8 (14%)
Inflammation, Acute 1 (2%) 1 (2%) 2 (3%)
Inflammation, Chronic 5 (8%) 4 (7%) 1 (2%) 2 (3%)
Inflammation, Chronic Active 1 (2%) 2 (3%)
Mineralization 1 (2%)
Atrium, Thrombosis 1 (2%)
Ventricle Right, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (60) (60) (59) (60)
Capsule, Hyperplasia 1 (2%)
Capsule, Spindle Cell, Hyperplasia 59 (98%) 57 (95%) 53 (90%) 55 (92%)
Adrenal Gland, Cortex (60) (60) (59) (59)
Hyperplasia 3 (5%) 2 (3%)
Hypertrophy 4 (7%) 3 (5%) 3 (5%) 3 (5%)
Pigmentation 8 (13%) 7 (12%) 10 (17%) 16 (27%)
Adrenal Gland, Medulla (60) (58) (58) (59)
Hyperplasia 1 (2%) 1 (2%)
Islets, Pancreatic (60) (60) (60) (58)
Hyperplasia 1 (2%) 1 (2%)
Necrosis 1 (2%)
Pituitary Gland (59) (58) (58) (56)
Pars Distalis, Cyst 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 2 (3%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (60) (60) (60) (59)
Infiltration Cellular, Lymphocyte 8 (13%) 5 (8%) 2 (3%) 3 (5%)
Inflammation, Acute 1 (2%)
C-Cell, Hyperplasia 1 (2%)
Follicle, Cyst 2 (3%) 1 (2%)
Follicle, Dilatation 3 (5%) 2 (3%) 3 (5%)
Follicle, Hyperplasia 4 (7%) 5 (8%) 2 (3%) 3 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (60) (60) (60)
Granuloma Sperm 3 (5%) 1 (2%)
Infiltration Cellular, Lymphocyte 9 (15%) 3 (5%) 8 (13%) 4 (7%)
Inflammation, Acute 1 (2%) 2 (3%) 3 (5%)
Inflammation, Chronic 2 (3%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 4 (7%)
Penis (17) (21) (17) (21)
Abscess 3 (14%) 1 (6%)
Concretion 1 (6%)
Inflammation 1 (6%) 1 (5%) 1 (5%)
Inflammation, Acute 16 (94%) 10 (48%) 13 (76%) 12 (57%)
Inflammation, Chronic 2 (10%) 1 (5%)
Inflammation, Chronic Active 2 (10%) 1 (5%)
Necrosis 2 (10%) 4 (24%) 4 (19%)
Preputial Gland (12) (9) (10) (11)
Abscess 4 (33%) 2 (22%) 3 (30%) 3 (27%)
Cyst 3 (25%) 2 (22%) 2 (20%) 2 (18%)
Infiltration Cellular, Lymphocyte 2 (22%) 1 (10%)
Inflammation, Acute 2 (17%) 1 (11%) 2 (18%)
Inflammation, Chronic 3 (25%) 1 (11%) 2 (20%)
Inflammation, Chronic Active 1 (8%) 1 (11%) 3 (30%) 2 (18%)
Prostate (60) (60) (59) (59)
Infiltration Cellular, Lymphocyte 8 (13%) 6 (10%) 16 (27%) 14 (24%)
Inflammation, Acute 14 (23%) 13 (22%) 9 (15%) 12 (20%)
Inflammation, Chronic 2 (3%) 2 (3%)
Inflammation, Chronic Active 2 (3%) 3 (5%) 1 (2%)
Seminal Vesicle (4) (4) (4) (6)
Dilatation 1 (25%) 2 (50%) 1 (17%)
Inflammation, Chronic 1 (25%) 1 (25%)
Inflammation, Chronic Active 1 (17%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Testes (60) (60) (60) (60)
Atrophy 9 (15%) 12 (20%) 3 (5%) 3 (5%)
Granuloma Sperm 2 (3%)
Hemorrhage 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Acute 1 (2%) 2 (3%)
Mineralization 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%) 1 (2%) 2 (3%)
Tunic, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (59)
Fibrosis 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%)
Myeloid Cell, Hyperplasia 51 (85%) 48 (80%) 56 (93%) 44 (75%)
Lymph Node (60) (60) (59) (59)
Congestion 2 (3%) 1 (2%)
Hyperplasia, Lymphoid 4 (7%) 3 (5%) 2 (3%) 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%) 1 (2%)
Iliac, Hyperplasia, Lymphoid 10 (17%) 4 (7%) 5 (8%) 4 (7%)
Iliac, Hyperplasia, Reticulum Cell 1 (2%)
Iliac, Inflammation, Acute 1 (2%) 1 (2%)
Inguinal, Hyperplasia, Lymphoid 2 (3%) 3 (5%) 1 (2%)
Lumbar, Hyperplasia, Lymphoid 2 (3%)
Mediastinal, Hyperplasia, Lymphoid 4 (7%) 1 (2%) 6 (10%) 5 (8%)
Mesenteric, Autolysis 1 (2%)
Mesenteric, Congestion 20 (33%) 14 (23%) 12 (20%) 11 (19%)
Mesenteric, Hematopoietic Cell Proliferation 1 (2%)
Mesenteric, Hemorrhage 1 (2%) 2 (3%)
Mesenteric, Hyperplasia, Lymphoid 32 (53%) 24 (40%) 35 (59%) 27 (46%)
Mesenteric, Inflammation, Acute 4 (7%) 5 (8%) 3 (5%) 10 (17%)
Renal, Congestion 1 (2%)
Renal, Hyperplasia, Lymphoid 2 (3%) 2 (3%) 2 (3%)
Lymph Node, Mandibular (53) (52) (54) (51)
Autolysis 1 (2%)
Congestion 1 (2%)
Hyperplasia, Lymphoid 38 (72%) 40 (77%) 38 (70%) 32 (63%)
Inflammation, Acute 1 (2%)
Necrosis 1 (2%)
Pigmentation 1 (2%)
Spleen (60) (60) (60) (59)
Angiectasis 1 (2%) 2 (3%)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 54 (90%) 50 (83%) 56 (93%) 47 (80%)
Hyperplasia, Lymphoid 10 (17%) 7 (12%) 6 (10%) 5 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Reticulum Cell 1 (2%)
Necrosis 2 (3%)
Pigmentation 4 (7%) 9 (15%) 11 (18%) 18 (31%)
Capsule, Inflammation, Chronic Active 1 (2%)
Thymus (53) (59) (58) (54)
Congestion 1 (2%)
Cyst 3 (6%) 2 (3%) 1 (2%)
Ectopic Parathyroid Gland 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 2 (3%) 4 (7%) 2 (4%)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (60) (60) (58)
Alopecia 4 (7%) 5 (8%) 3 (5%) 5 (9%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic 2 (3%) 1 (2%) 1 (2%)
Ulcer 3 (5%) 1 (2%) 2 (3%) 4 (7%)
Abdominal, Abscess 1 (2%)
Abdominal, Thoracic, Alopecia 1 (2%)
Foot, Ulcer 1 (2%) 2 (3%) 1 (2%)
Head, Abscess 1 (2%) 1 (2%)
Head, Inflammation, Acute 2 (3%) 1 (2%)
Head, Inflammation, Chronic 3 (5%) 1 (2%)
Head, Ulcer 1 (2%)
Inguinal, Abscess 1 (2%)
Inguinal, Inflammation, Acute 1 (2%)
Inguinal, Ulcer 1 (2%) 4 (7%) 2 (3%)
Neck, Abscess 1 (2%)
Neck, Alopecia 1 (2%)
Prepuce, Abscess 2 (3%) 2 (3%)
Prepuce, Inflammation, Acute 1 (2%)
Prepuce, Inflammation, Chronic Active 1 (2%) 1 (2%)
Prepuce, Ulcer 9 (15%) 14 (23%) 8 (13%) 10 (17%)
Scrotal, Abscess 5 (8%) 1 (2%) 1 (2%)
Scrotal, Inflammation, Acute 1 (2%)
Scrotal, Inflammation, Chronic Active 1 (2%)
Scrotal, Ulcer 16 (27%) 9 (15%) 16 (27%) 8 (14%)
Subcutaneous Tissue, Edema 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation, Acute 2 (3%) 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%)
Subcutaneous Tissue, Head, Abscess 2 (3%) 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Head, Granuloma 1 (2%)
Subcutaneous Tissue, Head, Inflammation,
Acute 1 (2%)
Subcutaneous Tissue, Head, Inflammation,
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Chronic Active 1 (2%)
Tail, Inflammation, Acute 1 (2%)
Tail, Inflammation, Chronic 1 (2%)
Tail, Necrosis 1 (2%)
Tail, Ulcer 1 (2%) 1 (2%)
Thoracic, Alopecia 1 (2%)
Ventral, Alopecia 2 (3%) 2 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Cranium, Inflammation, Chronic Active 1 (2%) 1 (2%)
Femur, Hyperostosis 1 (2%) 1 (2%)
Tibia, Fracture 1 (2%)
Skeletal Muscle (2) (6) (3)
Abscess 1 (17%)
Inflammation, Acute 1 (33%)
Inflammation, Chronic 1 (33%)
Inflammation, Chronic Active 1 (33%)
Head, Abscess 4 (67%)
Head, Inflammation, Acute 1 (50%)
Head, Inflammation, Chronic Active 1 (17%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Abscess 1 (2%)
Compression 1 (2%)
Hemorrhage 2 (3%) 3 (5%) 2 (3%) 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Mineralization 40 (67%) 35 (58%) 41 (68%) 35 (58%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Abscess 1 (2%)
Congestion 11 (18%) 12 (20%) 5 (8%) 8 (13%)
Granuloma 2 (3%)
Hemorrhage 6 (10%) 11 (18%) 16 (27%) 3 (5%)
Infiltration Cellular, Lymphocyte 50 (83%) 54 (90%) 55 (92%) 52 (87%)
Inflammation, Acute 1 (2%)
Mineralization 2 (3%)
Alveolar Epithelium, Hyperplasia 1 (2%) 2 (3%) 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 3 (5%) 1 (2%) 2 (3%) 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Arteriole, Inflammation, Acute 1 (2%)
Artery, Inflammation, Acute 1 (2%)
Interstitium, Inflammation, Acute 5 (8%) 1 (2%) 3 (5%) 4 (7%)
Interstitium, Inflammation, Chronic 1 (2%)
Peribronchiolar, Inflammation, Acute 1 (2%)
Peribronchiolar, Inflammation, Chronic 2 (3%) 1 (2%)
Peribronchiolar, Inflammation, Chronic Active 1 (2%)
Perivascular, Inflammation, Acute 1 (2%)
Nose (59) (59) (60) (59)
Lumen, Hemorrhage 36 (61%) 25 (42%) 40 (67%) 29 (49%)
Mucosa, Inflammation, Acute 1 (2%) 3 (5%) 1 (2%) 6 (10%)
Nasolacrimal Duct, Hemorrhage 2 (3%) 1 (2%)
Nasolacrimal Duct, Inflammation, Acute 1 (2%) 4 (7%) 5 (8%)
Olfactory Epithelium, Degeneration 41 (69%) 11 (19%) 27 (45%) 30 (51%)
Olfactory Epithelium, Metaplasia 1 (2%)
Respiratory Epithelium, Degeneration 7 (12%) 1 (2%) 8 (13%) 4 (7%)
Respiratory Epithelium, Inflammation, Acute 1 (2%)
Septum, Inflammation, Acute 1 (2%)
Septum, Inflammation, Chronic Active 1 (2%)
Sinus, Inflammation, Acute 1 (2%)
Turbinate, Congestion 1 (2%) 2 (3%)
Turbinate, Inflammation, Acute 1 (2%)
Vomeronasal Organ, Congestion 1 (2%)
Vomeronasal Organ, Inflammation, Acute 1 (2%) 2 (3%)
Trachea (60) (60) (60) (59)
Inflammation, Chronic Active 1 (2%)
Glands, Inflammation, Acute 3 (5%)
Mucosa, Erosion 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (1) (3)
Cyst 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (59)
Abscess 1 (2%) 1 (2%) 1 (2%)
Congestion 1 (2%)
Cyst 1 (2%)
Hemorrhage 1 (2%)
Hydronephrosis 1 (2%)
Infiltration Cellular, Lymphocyte 53 (88%) 52 (87%) 52 (87%) 48 (81%)
Inflammation, Acute 4 (7%) 3 (5%) 3 (5%) 3 (5%)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Metaplasia, Osseous 1 (2%)
Capsule, Inflammation, Chronic 1 (2%)
Cortex, Cyst 2 (3%) 2 (3%) 2 (3%)
Pelvis, Calculus Micro Observation Only 1 (2%)
Pelvis, Dilatation 14 (23%) 10 (17%) 9 (15%) 4 (7%)
Pelvis, Hemorrhage 1 (2%) 1 (2%)
Pelvis, Inflammation, Acute 7 (12%) 3 (5%) 5 (8%) 9 (15%)
Pelvis, Inflammation, Chronic 1 (2%)
Pelvis, Inflammation, Chronic Active 1 (2%) 1 (2%)
Renal Tubule, Casts Protein 4 (7%) 6 (10%) 4 (7%) 2 (3%)
Renal Tubule, Cyst 2 (3%) 1 (2%)
Renal Tubule, Dilatation 13 (22%) 17 (28%) 15 (25%) 17 (29%)
Renal Tubule, Hyperplasia 1 (2%) 3 (5%) 1 (2%)
Renal Tubule, Mineralization 2 (3%) 6 (10%) 1 (2%)
Renal Tubule, Necrosis 6 (10%) 12 (20%) 9 (15%) 12 (20%)
Renal Tubule, Regeneration 36 (60%) 30 (50%) 29 (48%) 21 (36%)
Ureter (8) (1) (3)
Dilatation 3 (38%) 1 (100%) 3 (100%)
Inflammation, Acute 1 (13%)
Urethra (5) (6) (1) (3)
Calculus Micro Observation Only 3 (60%) 4 (67%) 1 (33%)
Inflammation, Acute 1 (20%) 1 (17%) 1 (100%) 1 (33%)
Inflammation, Chronic 1 (20%)
Bulbourethral Gland, Inflammation, Acute 1 (17%)
Urinary Bladder (60) (60) (60) (59)
Angiectasis 2 (3%) 1 (2%)
Calculus Gross Observation 1 (2%) 1 (2%) 2 (3%)
Calculus Micro Observation Only 1 (2%) 2 (3%)
Congestion 1 (2%)
Ectasia 19 (32%) 10 (17%) 15 (25%) 13 (22%)
Hemorrhage 1 (2%)
Infiltration Cellular, Lymphocyte 27 (45%) 25 (42%) 36 (60%) 31 (53%)
Inflammation, Acute 10 (17%) 8 (13%) 7 (12%) 11 (19%)
Inflammation, Chronic 1 (2%) 3 (5%)
Inflammation, Chronic Active 6 (10%) 1 (2%) 4 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
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