TR 371 Mouse Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
TOLUENE
NTP Experiment-Test: 05701-03 Report: PEIRPT05
Study Type: CHRONIC Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:15
Facility: International Research and Development Corp.
Chemical CAS #: 108883
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Dead 11 6 13 9
Moribund 8 8 11 3
Accident 1 3 1
Natural Death 2 2
Survivors
Terminal Sacrifice 30 33 23 32
Dead 1
Missing 3
Animals Examined Microscopically 50 50 50 47
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (49) (49) (50) (45)
Intestine Large, Cecum (49) (50) (50) (47)
Histiocytic Sarcoma 1 (2%)
Intestine Large, Rectum (50) (50) (50) (45)
Intestine Small, Duodenum (49) (50) (50) (47)
Intestine Small, Jejunum (49) (50) (50) (47)
Liver (49) (50) (50) (47)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 4 (8%) 2 (4%) 2 (4%) 7 (15%)
Hepatocellular Adenoma 3 (6%) 7 (14%) 6 (12%) 7 (15%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Mesentery (5) (2) (4) (2)
Hepatocellular Carcinoma, Metastatic, Liver 1 (50%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (50%)
Pancreas (50) (50) (50) (47)
Salivary Glands (50) (50) (50) (46)
Stomach (50) (50) (50) (47)
Histiocytic Sarcoma 1 (2%)
Stomach, Forestomach (50) (49) (50) (47)
Squamous Cell Papilloma 3 (6%) 1 (2%) 1 (2%) 3 (6%)
Stomach, Glandular (49) (50) (50) (47)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (47)
Heart (50) (50) (50) (47)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Metastatic, Ovary 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (50) (50) (47)
Adenoma 1 (2%) 1 (2%)
Adrenal Gland, Medulla (49) (50) (49) (47)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma NOS 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Pituitary Gland (49) (48) (49) (46)
Pars Distalis, Adenoma 12 (24%) 19 (40%) 21 (43%) 15 (33%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%) 1 (2%)
Thyroid Gland (50) (50) (50) (47)
Follicle, Adenocarcinoma 1 (2%)
Follicle, Adenoma 4 (8%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (49) (50) (47)
Granulosa Cell Tumor Benign 1 (2%)
Hemangioma 1 (2%) 1 (2%)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Metastatic 1 (2%)
Histiocytic Sarcoma 1 (2%)
Luteoma 1 (2%)
Uterus (50) (50) (50) (47)
Adenocarcinoma 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Leiomyoma 1 (2%)
Endometrium, Polyp Stromal 3 (6%) 2 (4%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (1) (1)
Bone Marrow (50) (50) (50) (47)
Hemangioma 1 (2%)
Hemangiosarcoma, Metastatic, Ovary 1 (2%)
Hemangiosarcoma, Metastatic, Skin 1 (2%)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Lymph Node (48) (49) (50) (46)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Iliac, Histiocytic Sarcoma 1 (2%) 1 (2%)
Mesenteric, Histiocytic Sarcoma 2 (4%)
Mesenteric, Osteosarcoma, Metastatic,
Uncertain Primary Site 1 (2%)
Renal, Histiocytic Sarcoma 2 (4%)
Lymph Node, Mandibular (47) (48) (50) (43)
Histiocytic Sarcoma 1 (2%)
Spleen (50) (50) (49) (47)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%) 2 (4%)
Hemangiosarcoma, Metastatic, Uterus 1 (2%)
Histiocytic Sarcoma 2 (4%) 1 (2%)
Thymus (46) (48) (48) (47)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (48) (46)
Adenoacanthoma 1 (2%)
Adenocarcinoma 2 (4%) 2 (4%)
Carcinoma 1 (2%)
Skin (50) (50) (50) (47)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (2%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (2)
Head, Sarcoma, Deep Invasion 1 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (47)
Meninges, Sarcoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (47)
Alveolar/Bronchiolar Adenoma 5 (10%) 3 (6%) 4 (9%)
Alveolar/Bronchiolar Carcinoma 3 (6%) 1 (2%) 3 (6%)
Carcinoma, Metastatic 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 2 (4%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (2) (3)
Adenoma 2 (67%) 1 (50%) 1 (33%)
Carcinoma 1 (33%)
Bilateral, Adenocarcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (47)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Urinary Bladder (50) (50) (50) (47)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(47)
Histiocytic Sarcoma 2 (4%) 1 (2%)
Leukemia 1 (2%)
Lymphoma Malignant 1 (2%)
Lymphoma Malignant Histiocytic 2 (4%) 1 (2%) 1 (2%)
Lymphoma Malignant Lymphocytic 2 (4%) 1 (2%) 2 (4%)
Lymphoma Malignant Mixed 20 (40%) 10 (20%) 13 (26%) 6 (13%)
Lymphoma Malignant Undifferentiated Cell 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 33 36 42 38
Total Primary Neoplasms 63 59 69 70
Total Animals with Benign Neoplasms 19 28 29 29
Total Benign Neoplasms 29 35 39 37
Total Animals with Malignant Neoplasms 26 17 27 26
Total Malignant Neoplasms 33 23 29 31
Total Animals with Metastatic Neoplasms 1 2 1 8
Total Metastatic Neoplasm 1 3 1 13
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1 1 2
Total Uncertain Neoplasms 1 1 1 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Early Deaths
Moribund 19 18 23 17
Dead 23 19 16 21
Accident 1 2 2
Natural Death 1 3 1
Survivors
Terminal Sacrifice 17 21 16 19
Dead 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (59) (54) (57) (59)
Intestine Large, Cecum (60) (60) (60) (59)
Intestine Large, Colon (60) (60) (60) (59)
Intestine Small, Jejunum (60) (60) (60) (60)
Liver (60) (60) (60) (59)
Hemangioma 1 (2%)
Hemangiosarcoma 2 (3%) 1 (2%)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Hepatocellular Carcinoma 13 (22%) 8 (13%) 9 (15%) 8 (14%)
Hepatocellular Adenoma 7 (12%) 10 (17%) 9 (15%) 10 (17%)
Hepatocellular Adenoma, Multiple 1 (2%)
Histiocytic Sarcoma 1 (2%)
Ito Cell Tumor Malignant 1 (2%)
Mesentery (2) (2) (1)
Pancreas (60) (60) (60) (59)
Salivary Glands (60) (60) (60) (59)
Stomach, Forestomach (60) (59) (60) (60)
Squamous Cell Papilloma 1 (2%) 1 (2%) 1 (2%)
Stomach, Glandular (60) (60) (60) (60)
Tooth (2) (8) (2) (1)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (59)
Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (60) (60) (59) (60)
Capsule, Spindle Cell, Adenoma 1 (2%)
Adrenal Gland, Cortex (60) (60) (59) (59)
Adenoma 1 (2%)
Islets, Pancreatic (60) (60) (60) (58)
Adenoma 1 (2%) 1 (2%)
Pituitary Gland (59) (58) (58) (56)
Pars Distalis, Adenoma 2 (3%) 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (60) (60) (60) (59)
Follicle, Adenoma 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (60) (60) (60)
Preputial Gland (12) (9) (10) (11)
Prostate (60) (60) (59) (59)
Seminal Vesicle (4) (4) (4) (6)
Testes (60) (60) (60) (60)
Interstitial Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (59)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Lymph Node (60) (60) (59) (59)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mediastinal, Histiocytic Sarcoma 1 (2%)
Mesenteric, Hemangiosarcoma, Metastatic,
Liver 1 (2%)
Mesenteric, Histiocytic Sarcoma 1 (2%)
Renal, Histiocytic Sarcoma 1 (2%)
Lymph Node, Mandibular (53) (52) (54) (51)
Spleen (60) (60) (60) (59)
Hemangiosarcoma 1 (2%) 3 (5%)
Histiocytic Sarcoma 1 (2%)
Thymus (53) (59) (58) (54)
Page 8
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Histiocytic Sarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (60) (60) (58)
Neck, Subcutaneous Tissue, Hemangioma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Skeletal Muscle (2) (6) (3)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Adenocarcinoma, Metastatic, Harderian Gland 1 (2%)
Alveolar/Bronchiolar Adenoma 8 (13%) 1 (2%) 2 (3%) 7 (12%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 2 (3%) 1 (2%) 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 3 (5%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Nose (59) (59) (60) (59)
Adenocarcinoma, Metastatic, Harderian Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (1) (3)
Adenocarcinoma 1 (100%)
Adenoma 3 (100%) 2 (67%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (59)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Lipoma 1 (2%)
Urinary Bladder (60) (60) (60) (59)
Page 9
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Lymphoma Malignant Histiocytic 3 (5%)
Lymphoma Malignant Lymphocytic 2 (3%)
Lymphoma Malignant Mixed 5 (8%) 7 (12%) 6 (10%) 3 (5%)
Lymphoma Malignant Undifferentiated Cell 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05701-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:49:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 120 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 29 29 26 33
Total Primary Neoplasms 41 41 35 44
Total Animals with Benign Neoplasms 16 18 14 19
Total Benign Neoplasms 18 22 16 24
Total Animals with Malignant Neoplasms 20 16 17 17
Total Malignant Neoplasms 23 19 19 20
Total Animals with Metastatic Neoplasms 4 3 2
Total Metastatic Neoplasm 5 5 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
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