TR 371 Mouse Pathology Tables
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
Facility: International Research and Development Corp.
Chemical CAS #: 108883
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 7| 7| 3| 7| 7|
DAY ON TEST | 5| 2| 2| 1| 3| 3| 5| 3| 5| 1| 3| 2| 3| 2| 5| 3| 3| 3| 3| 5| 2| 3| 7| 1| 2|
| 7| 9| 4| 6| 2| 2| 7| 3| 7| 6| 1| 9| 2| 2| 7| 3| 4| 0| 0| 7| 9| 3| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + M + + + + + + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Lymphocyte | 2 1 1 2 2 2 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
Anorectal Junction, Inflammation, | |
Acute | 3 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + A + + + + + + +|
Basophilic Focus | X |
Fatty Change | |
Hematopoietic Cell Proliferation | 3 2 2 2 2 1 1 1 1 1|
Hyperplasia, Lymphoid | |
Infarct | |
Infiltration Cellular, Lymphocyte | 2 2 1 1 2 1 2 2 1|
Inflammation, Acute | |
Necrosis | 2 |
Thrombosis | X |
Hepatocyte, Hypertrophy | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Lymphocyte | 2 1 2 2 2 2 2 1 1 1|
Inflammation, Chronic Active | |
Acinus, Atrophy | 2 4 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Lymphocyte | 1 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 7| 7| 3| 7| 7|
DAY ON TEST | 5| 2| 2| 1| 3| 3| 5| 3| 5| 1| 3| 2| 3| 2| 5| 3| 3| 3| 3| 5| 2| 3| 7| 1| 2|
| 7| 9| 4| 6| 2| 2| 7| 3| 7| 6| 1| 9| 2| 2| 7| 3| 4| 0| 0| 7| 9| 3| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperplasia, Focal, Squamous | |
Hyperplasia, Squamous | |
Infiltration Cellular, Lymphocyte | 1 2 2 |
Inflammation, Acute | |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 1 2 1|
Inflammation, Acute | 2 |
Ulcer | 3 |
Mucosa, Dilatation | 1 2 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 3 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 2 |
Mineralization | |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
Capsule, Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Degeneration, Fatty | 2 |
Hyperplasia | |
Hypertrophy | 2 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Thrombosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M + + M + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Hyperplasia | 2 3 3 2 3 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Lymphocyte | 2 2 1 1 |
Follicle, Dilatation | 3 2 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 7| 7| 3| 7| 7|
DAY ON TEST | 5| 2| 2| 1| 3| 3| 5| 3| 5| 1| 3| 2| 3| 2| 5| 3| 3| 3| 3| 5| 2| 3| 7| 1| 2|
| 7| 9| 4| 6| 2| 2| 7| 3| 7| 6| 1| 9| 2| 2| 7| 3| 4| 0| 0| 7| 9| 3| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Hyperplasia | 3 4 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Abscess | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Periovarian Tissue, Cyst | X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Endometrium, Hyperplasia, Cystic | 3 2 2 4 3 3 2 3 4 3 2 3 3 4 3 3 2 3|
Endometrium, Inflammation, Acute | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Fibrosis | 2 2 2 1 3 4 3 1 2|
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + M + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
Inflammation, Acute | 2 |
Iliac, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mesenteric, Angiectasis | 3 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 1 2 2 2 2 |
Mesenteric, Inflammation, Acute | 3 |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 2 1 2 3 2 3 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 3 2 2 2 3 2 2 2 2 2 2 2 2 2|
Hyperplasia, Lymphoid | 4 2 2 2 3 3 3 3 |
Inflammation, Chronic | 2 |
Necrosis | |
Pigmentation | 1 2 2 1 1 2 1 2 2 1 1 2 2 2 1|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M +|
Cyst | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 7| 7| 3| 7| 7|
DAY ON TEST | 5| 2| 2| 1| 3| 3| 5| 3| 5| 1| 3| 2| 3| 2| 5| 3| 3| 3| 3| 5| 2| 3| 7| 1| 2|
| 7| 9| 4| 6| 2| 2| 7| 3| 7| 6| 1| 9| 2| 2| 7| 3| 4| 0| 0| 7| 9| 3| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 3 2 2 |
Inflammation, Acute | |
Ulcer | |
Head, Ulcer | |
Inguinal, Inflammation, Acute | |
Subcutaneous Tissue, Hemorrhage | |
Ventral, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1|
Infiltration Cellular, Lymphocyte | 1 |
Mineralization | 2 3 2 3 2 2 2 2 2 2 2 2 2|
Ventricle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2|
Hemorrhage | 2 2 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Mineralization | 2 |
Pigmentation, Cholesterol | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Interstitium, Inflammation, Acute | 1 |
Peribronchiolar, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 2 2 2 1 2 1 1 2 2 1 1 1 2 2|
Mucosa, Inflammation, Acute | 2 1|
Nasolacrimal Duct, Hemorrhage | |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Respiratory Epithelium, Degeneration | 1 2 2 1 1 1 |
Turbinate, Inflammation, Acute | |
Vomeronasal Organ, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 7| 7| 3| 7| 7|
DAY ON TEST | 5| 2| 2| 1| 3| 3| 5| 3| 5| 1| 3| 2| 3| 2| 5| 3| 3| 3| 3| 5| 2| 3| 7| 1| 2|
| 7| 9| 4| 6| 2| 2| 7| 3| 7| 6| 1| 9| 2| 2| 7| 3| 4| 0| 0| 7| 9| 3| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Infarct | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 |
Metaplasia, Osseous | 1 3 2 |
Pelvis, Dilatation | 2 |
Renal Tubule, Casts Protein | 1 1 1 |
Renal Tubule, Dilatation | 1 2 1 1 1 1 1 1 1 1|
Renal Tubule, Necrosis | 1 1 |
Renal Tubule, Regeneration | 1 2 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 6| 4| 5| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 0| 3| 3| 2| 3| 3| 3| 5| 5| 5| 5| 9| 3| 5| 2| 1| 3| 8| 3| 3| 3| 6| 5|
| 2| 3| 9| 1| 6| 9| 0| 2| 0| 7| 3| 7| 6| 3| 1| 7| 9| 4| 0| 3| 0| 0| 1| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + M + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 4 |
Infiltration Cellular, Lymphocyte | 2 2 1 1 2 1 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + |
Anorectal Junction, Inflammation, | |
Acute | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + |
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | |
Fatty Change | 2 |
Hematopoietic Cell Proliferation | 1 2 1 1 1 2 2 1 |
Hyperplasia, Lymphoid | 4 |
Infarct | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 1 1 2 1 2 2 2 |
Inflammation, Acute | 1 |
Necrosis | 2 2 4 1 |
Thrombosis | |
Hepatocyte, Hypertrophy | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 4 4 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 |
Inflammation, Chronic Active | 3 |
Acinus, Atrophy | 4 |
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 4 |
Infiltration Cellular, Lymphocyte | 2 2 2 1 2 2 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + |
Erosion | |
Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 6| 4| 5| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 0| 3| 3| 2| 3| 3| 3| 5| 5| 5| 5| 9| 3| 5| 2| 1| 3| 8| 3| 3| 3| 6| 5|
| 2| 3| 9| 1| 6| 9| 0| 2| 0| 7| 3| 7| 6| 3| 1| 7| 9| 4| 0| 3| 0| 0| 1| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperplasia, Focal, Squamous | 3 3 |
Hyperplasia, Squamous | |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Acute | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + |
Erosion | 2 |
Hyperplasia, Lymphoid | 4 |
Infiltration Cellular, Lymphocyte | 2 1 2 2 2 |
Inflammation, Acute | 1 2 |
Ulcer | |
Mucosa, Dilatation | 2 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 1 2 1 1 1 1 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 2 |
Mineralization | 3 |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + M + + + + + + + + + + + + + + + + + |
Capsule, Spindle Cell, Hyperplasia | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + M + + + + + + + + + + + + + + + + + |
Cyst | X |
Degeneration, Fatty | |
Hyperplasia | 2 |
Hypertrophy | |
Pigmentation | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Thrombosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M M + M M + + + + + M M M + M + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 1 3 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 4 |
Infiltration Cellular, Lymphocyte | |
Follicle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 6| 4| 5| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 0| 3| 3| 2| 3| 3| 3| 5| 5| 5| 5| 9| 3| 5| 2| 1| 3| 8| 3| 3| 3| 6| 5|
| 2| 3| 9| 1| 6| 9| 0| 2| 0| 7| 3| 7| 6| 3| 1| 7| 9| 4| 0| 3| 0| 0| 1| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Hyperplasia | 3 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Abscess | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 4 |
Periovarian Tissue, Cyst | X X X 3 X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Endometrium, Hyperplasia, Cystic | 2 3 2 2 3 2 3 2 2 3 2 2 3 3 2 3 2 3 3 3 |
Endometrium, Inflammation, Acute | 3 2 2 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Fibrosis | 2 2 1 2 2 3 3 4 3 4 3 3 2 |
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 4 |
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
Iliac, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | |
Mesenteric, Angiectasis | |
Mesenteric, Hyperplasia, Lymphoid | 2 2 4 2 3 4 2 4 |
Mesenteric, Inflammation, Acute | |
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 2 1 2 4 2 2 4 2 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 |
Hyperplasia, Lymphoid | 2 4 3 3 4 |
Inflammation, Chronic | |
Necrosis | 4 |
Pigmentation | 1 2 2 1 2 2 2 2 2 2 2 2 1 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + M |
Cyst | X X |
Hyperplasia, Lymphoid | 2 4 4 4 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 6| 4| 5| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 0| 3| 3| 2| 3| 3| 3| 5| 5| 5| 5| 9| 3| 5| 2| 1| 3| 8| 3| 3| 3| 6| 5|
| 2| 3| 9| 1| 6| 9| 0| 2| 0| 7| 3| 7| 6| 3| 1| 7| 9| 4| 0| 3| 0| 0| 1| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + |
Ectasia | 2 1 2 2 3 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Alopecia | 3 2 2 2 |
Inflammation, Acute | 1 |
Ulcer | 2 |
Head, Ulcer | 3 |
Inguinal, Inflammation, Acute | 3 |
Subcutaneous Tissue, Hemorrhage | 2 |
Ventral, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 2 1 1 |
Infiltration Cellular, Lymphocyte | 2 2 |
Mineralization | 2 2 1 2 2 2 2 2 1 2 1 2 1 2 2 2 |
Ventricle, Dilatation | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 2 3 2 2 |
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | 4 4 4 |
Infiltration Cellular, Lymphocyte | 2 1 2 2 2 2 2 1 2 2 |
Mineralization | |
Pigmentation, Cholesterol | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Interstitium, Inflammation, Acute | 1 |
Peribronchiolar, Inflammation, Acute | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
Lumen, Hemorrhage | 2 2 3 1 2 1 2 2 2 2 2 2 |
Mucosa, Inflammation, Acute | |
Nasolacrimal Duct, Hemorrhage | |
Olfactory Epithelium, Degeneration | 2 2 2 2 3 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 |
Respiratory Epithelium, Degeneration | 1 2 1 1 1 1 1 1 1 |
Turbinate, Inflammation, Acute | 2 |
Vomeronasal Organ, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 6| 4| 5| 6| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 0| 3| 3| 2| 3| 3| 3| 5| 5| 5| 5| 9| 3| 5| 2| 1| 3| 8| 3| 3| 3| 6| 5|
| 2| 3| 9| 1| 6| 9| 0| 2| 0| 7| 3| 7| 6| 3| 1| 7| 9| 4| 0| 3| 0| 0| 1| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 4 4 4 |
Infarct | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 |
Metaplasia, Osseous | 2 |
Pelvis, Dilatation | 3 |
Renal Tubule, Casts Protein | 1 1 1 |
Renal Tubule, Dilatation | 1 1 1 1 1 1 1 1 2 2 1 |
Renal Tubule, Necrosis | 2 1 |
Renal Tubule, Regeneration | 1 2 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 |
Hyperplasia, Lymphoid | 4 4 4 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 3| 0| 4| 7| 7| 7| 3| 7| 7| | |
DAY ON TEST | 8| 4| 0| 5| 3| 2| 3| 9| 2| 3| | |
| 1| 7| 4| 7| 3| 9| 1| 3| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + | 49 |
Hyperplasia, Lymphoid | 4 | 2 4.0|
Infiltration Cellular, Lymphocyte | 2 | 14 1.6|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
Anorectal Junction, Inflammation, | | |
Acute | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 49 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 50 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 49 |
Amyloid Deposition | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 49 |
Basophilic Focus | | 1 |
Fatty Change | | 1 2.0|
Hematopoietic Cell Proliferation | 2 1 1 1 1 | 23 1.4|
Hyperplasia, Lymphoid | 4 | 2 4.0|
Infarct | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 1 2 2 | 23 1.7|
Inflammation, Acute | | 1 1.0|
Necrosis | 3 2 | 7 2.3|
Thrombosis | | 1 |
Hepatocyte, Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | 4 | 4 3.5|
Infiltration Cellular, Lymphocyte | 1 2 1 | 17 1.6|
Inflammation, Chronic Active | | 1 3.0|
Acinus, Atrophy | | 3 3.3|
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | 4 4 | 4 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 3| 0| 4| 7| 7| 7| 3| 7| 7| | |
DAY ON TEST | 8| 4| 0| 5| 3| 2| 3| 9| 2| 3| | |
| 1| 7| 4| 7| 3| 9| 1| 3| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Infiltration Cellular, Lymphocyte | 1 2 2 2 | 28 1.9|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
Erosion | 2 | 1 2.0|
Hyperkeratosis | | 2 2.0|
Hyperplasia, Focal, Squamous | | 2 3.0|
Hyperplasia, Squamous | 2 2 | 2 2.0|
Infiltration Cellular, Lymphocyte | 2 | 5 1.6|
Inflammation, Acute | 2 | 2 2.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 49 |
Erosion | 3 | 2 2.5|
Hyperplasia, Lymphoid | 4 | 2 4.0|
Infiltration Cellular, Lymphocyte | 2 2 | 15 1.8|
Inflammation, Acute | 3 | 4 2.0|
Ulcer | 3 | 2 3.0|
Mucosa, Dilatation | 1 2 1 | 10 1.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 1 | 10 1.3|
Inflammation, Chronic | | 2 1.0|
Inflammation, Chronic Active | | 2 2.0|
Mineralization | | 1 3.0|
Valve, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 49 |
Capsule, Spindle Cell, Hyperplasia | 3 2 2 2 3 2 2 2 2 | 49 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 49 |
Cyst | | 1 |
Degeneration, Fatty | | 1 2.0|
Hyperplasia | | 1 2.0|
Hypertrophy | | 1 2.0|
Pigmentation | 2 2 2 2 2 2 | 35 2.0|
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 49 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 3| 0| 4| 7| 7| 7| 3| 7| 7| | |
DAY ON TEST | 8| 4| 0| 5| 3| 2| 3| 9| 2| 3| | |
| 1| 7| 4| 7| 3| 9| 1| 3| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M + + M + M | 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 49 |
Pars Distalis, Angiectasis | | 2 2.5|
Pars Distalis, Hyperplasia | 3 3 | 12 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | | 1 4.0|
Infiltration Cellular, Lymphocyte | 1 | 5 1.4|
Follicle, Dilatation | | 8 2.0|
Follicle, Hyperplasia | 1 | 9 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Abscess | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | 4 | 2 4.0|
Periovarian Tissue, Cyst | X | 11 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 50 |
Angiectasis | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 3 3 3 3 3 3 | 45 2.7|
Endometrium, Inflammation, Acute | 1 | 4 2.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Angiectasis | | 1 1.0|
Fibrosis | 1 2 3 | 25 2.4|
Myeloid Cell, Hyperplasia | 2 2 2 | 33 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + M + + + + + + | 48 |
Hemorrhage | | 1 4.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Acute | | 1 2.0|
Iliac, Hyperplasia, Lymphoid | 4 2 | 3 2.7|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 3| 0| 4| 7| 7| 7| 3| 7| 7| | |
DAY ON TEST | 8| 4| 0| 5| 3| 2| 3| 9| 2| 3| | |
| 1| 7| 4| 7| 3| 9| 1| 3| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mesenteric, Angiectasis | | 1 3.0|
Mesenteric, Hyperplasia, Lymphoid | 2 3 2 4 2 2 | 26 2.3|
Mesenteric, Inflammation, Acute | | 1 3.0|
Renal, Hyperplasia, Lymphoid | 4 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + M + + + | 47 |
Hyperplasia, Lymphoid | 2 2 2 4 2 2 2 | 31 2.2|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 3 2 2 | 41 2.1|
Hyperplasia, Lymphoid | 2 4 4 | 16 3.0|
Inflammation, Chronic | | 1 2.0|
Necrosis | | 1 4.0|
Pigmentation | 2 1 2 2 2 2 | 37 1.7|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + | 46 |
Cyst | | 2 |
Hyperplasia, Lymphoid | 4 2 | 7 3.1|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 49 |
Ectasia | 2 4 2 2 | 16 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Alopecia | 2 | 9 2.2|
Inflammation, Acute | | 1 1.0|
Ulcer | | 1 2.0|
Head, Ulcer | | 1 3.0|
Inguinal, Inflammation, Acute | | 1 3.0|
Subcutaneous Tissue, Hemorrhage | | 1 2.0|
Ventral, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
Hemorrhage | 2 | 5 1.4|
Infiltration Cellular, Lymphocyte | 2 | 4 1.8|
Mineralization | 2 2 2 2 2 1 | 35 1.9|
Ventricle, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 3| 0| 4| 7| 7| 7| 3| 7| 7| | |
DAY ON TEST | 8| 4| 0| 5| 3| 2| 3| 9| 2| 3| | |
| 1| 7| 4| 7| 3| 9| 1| 3| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Congestion | 2 2 3 1 2 | 13 2.1|
Hemorrhage | | 5 2.0|
Hyperplasia, Lymphoid | 4 4 | 5 4.0|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 | 30 1.9|
Mineralization | 2 | 2 2.0|
Pigmentation, Cholesterol | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 1.5|
Interstitium, Inflammation, Acute | 1 | 3 1.0|
Peribronchiolar, Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 50 |
Lumen, Hemorrhage | 2 2 3 2 1 | 31 1.8|
Mucosa, Inflammation, Acute | 1 | 3 1.3|
Nasolacrimal Duct, Hemorrhage | 1 | 1 1.0|
Olfactory Epithelium, Degeneration | 2 3 2 2 2 2 2 2 | 48 2.0|
Respiratory Epithelium, Degeneration | 1 1 1 | 18 1.2|
Turbinate, Inflammation, Acute | | 1 2.0|
Vomeronasal Organ, Inflammation, | | |
Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | 4 4 | 6 3.7|
Infarct | 3 | 1 3.0|
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 | 31 1.9|
Metaplasia, Osseous | | 4 2.0|
Pelvis, Dilatation | | 2 2.5|
Renal Tubule, Casts Protein | | 6 1.0|
Renal Tubule, Dilatation | 2 1 1 | 24 1.2|
Renal Tubule, Necrosis | 1 | 5 1.2|
Renal Tubule, Regeneration | 2 2 | 14 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 50 |
Angiectasis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 3| 0| 4| 7| 7| 7| 3| 7| 7| | |
DAY ON TEST | 8| 4| 0| 5| 3| 2| 3| 9| 2| 3| | |
| 1| 7| 4| 7| 3| 9| 1| 3| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 4 | 5 3.6|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 | 31 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 5| 4| 4| 7| 5| 7| 5| 7| 7| 4|
DAY ON TEST | 3| 3| 6| 1| 0| 3| 3| 5| 3| 3| 3| 9| 3| 3| 2| 7| 5| 5| 0| 1| 2| 9| 2| 3| 5|
| 0| 0| 3| 2| 5| 3| 1| 7| 3| 1| 2| 8| 3| 2| 9| 8| 7| 7| 8| 8| 5| 8| 9| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 2 |
Inflammation, Acute | 3 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + |
Anorectal Junction, Inflammation, | |
Chronic Active | 2 |
Anus, Inflammation, Acute | 4 |
Anus, Ulcer | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 4 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Fatty Change | |
Hematopoietic Cell Proliferation | 2 1 1 1 2 1 2 2 2 3 2 2 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 |
Necrosis | 2 |
Vacuolization Cytoplasmic | |
Serosa, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 1 2 2 2 2 2 2 2 2 1 |
Inflammation, Acute | 3 |
Acinus, Atrophy | 3 4 |
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 1 2 2 1 2 2 2 2 3 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal, Squamous | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + |
Erosion | 2 |
Hyperplasia, Focal, Squamous | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 5| 4| 4| 7| 5| 7| 5| 7| 7| 4|
DAY ON TEST | 3| 3| 6| 1| 0| 3| 3| 5| 3| 3| 3| 9| 3| 3| 2| 7| 5| 5| 0| 1| 2| 9| 2| 3| 5|
| 0| 0| 3| 2| 5| 3| 1| 7| 3| 1| 2| 8| 3| 2| 9| 8| 7| 7| 8| 8| 5| 8| 9| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperplasia, Squamous | 3 |
Infiltration Cellular, Lymphocyte | 2 2 |
Inflammation, Acute | 2 2 |
Inflammation, Chronic Active | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + |
Edema | |
Erosion | 3 |
Infiltration Cellular, Lymphocyte | 2 1 2 2 1 2 2 2 2 1 2 |
Inflammation, Acute | 2 2 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | |
Mineralization | 1 |
Ulcer | 3 3 |
Mucosa, Dilatation | 2 2 1 2 1 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Acute | 4 |
Inflammation, Chronic | 2 |
Atrium, Thrombosis | 4 |
Coronary Artery, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
Capsule, Inflammation, Acute | 2 |
Capsule, Spindle Cell, Hyperplasia | 2 2 2 2 2 3 2 2 2 3 2 2 2 2 2 2 2 3 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Degeneration, Fatty | |
Hypertrophy | 2 |
Necrosis | |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 |
Thrombosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + + + + |
Hyperplasia | 2 |
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M M + M M M M M + M M M M M + M M + M M M |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 5| 4| 4| 7| 5| 7| 5| 7| 7| 4|
DAY ON TEST | 3| 3| 6| 1| 0| 3| 3| 5| 3| 3| 3| 9| 3| 3| 2| 7| 5| 5| 0| 1| 2| 9| 2| 3| 5|
| 0| 0| 3| 2| 5| 3| 1| 7| 3| 1| 2| 8| 3| 2| 9| 8| 7| 7| 8| 8| 5| 8| 9| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 2 2 2 3 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 1 2 |
Inflammation, Acute | |
Inflammation, Chronic | |
C-Cell, Hyperplasia | |
Follicle, Dilatation | 2 |
Follicle, Hyperplasia | 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Cyst | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + |
Abscess | 4 |
Hemorrhage | 3 |
Infiltration Cellular, Lymphocyte | 3 |
Inflammation, Acute | |
Pigmentation, Hemosiderin, | |
Cholesterol | 3 |
Follicle, Cyst | X |
Follicle, Cyst Multilocular | X |
Periovarian Tissue, Cyst | X X X |
__________________________________________________________________________|
Oviduct | |
Inflammation, Acute | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 3 2 2 4 3 3 3 2 2 3 3 |
Endometrium, Inflammation, Acute | 2 2 4 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
Fibrosis | 2 2 2 2 2 2 2 1 2 2 1 |
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | |
Bronchial, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 5| 4| 4| 7| 5| 7| 5| 7| 7| 4|
DAY ON TEST | 3| 3| 6| 1| 0| 3| 3| 5| 3| 3| 3| 9| 3| 3| 2| 7| 5| 5| 0| 1| 2| 9| 2| 3| 5|
| 0| 0| 3| 2| 5| 3| 1| 7| 3| 1| 2| 8| 3| 2| 9| 8| 7| 7| 8| 8| 5| 8| 9| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Congestion | 2 3 3 4 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 |
Mesenteric, Inflammation, Acute | 2 2 3 2 |
Renal, Congestion | |
Renal, Hyperplasia, Lymphoid | |
Renal, Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Glandular | |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Hyperplasia | |
Inflammation, Acute | 2 3 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 3 2 2 3 2 2 2 2 4 3 2 2 |
Hyperplasia, Lymphoid | 2 2 2 2 2 |
Infiltration Cellular | 2 |
Pigmentation | 2 2 2 2 2 2 2 1 2 2 2 1 2 |
Capsule, Inflammation, Acute | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Ectopic Thyroid | |
Edema | |
Hyperplasia, Lymphoid | 3 2 2 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + + M + + + + + |
Ectasia | 2 2 1 2 4 2 |
Acinus, Ectasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Alopecia | 2 3 2 |
Inflammation, Chronic | |
Foot, Ulcer | 4 |
Head, Ulcer | |
Inguinal, Ulcer | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Inflammation, | |
Acute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
Femur, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | + |
Head, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 5| 4| 4| 7| 5| 7| 5| 7| 7| 4|
DAY ON TEST | 3| 3| 6| 1| 0| 3| 3| 5| 3| 3| 3| 9| 3| 3| 2| 7| 5| 5| 0| 1| 2| 9| 2| 3| 5|
| 0| 0| 3| 2| 5| 3| 1| 7| 3| 1| 2| 8| 3| 2| 9| 8| 7| 7| 8| 8| 5| 8| 9| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Compression | 3 2 |
Hemorrhage | 2 1 |
Infiltration Cellular, Lymphocyte | 2 2 1 |
Mineralization | 2 2 2 2 2 2 2 1 2 2 3 1 |
Nerve, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 2 2 2 |
Hemorrhage | 1 2 3 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2 |
Interstitium, Inflammation, Acute | |
Interstitium, Inflammation, Chronic | |
Peribronchiolar, Inflammation, Acute | |
Pleura, Inflammation, Chronic | |
Pleura, Interstitium, Inflammation, | |
Acute | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
Lumen, Hemorrhage | 1 2 2 2 2 2 2 1 2 2 2 3 2 2 2 |
Mucosa, Inflammation, Acute | 2 2 3 |
Nasolacrimal Duct, Hemorrhage | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | 3 2 |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 2 2 1 2 1 1 3 2 1 |
Respiratory Epithelium, Degeneration | 1 2 1 1 2 3 |
Turbinate, Inflammation, Acute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Abscess | 4 |
Hemorrhage | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 |
Inflammation, Chronic | 4 |
Inflammation | 4 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 5| 4| 4| 7| 5| 7| 5| 7| 7| 4|
DAY ON TEST | 3| 3| 6| 1| 0| 3| 3| 5| 3| 3| 3| 9| 3| 3| 2| 7| 5| 5| 0| 1| 2| 9| 2| 3| 5|
| 0| 0| 3| 2| 5| 3| 1| 7| 3| 1| 2| 8| 3| 2| 9| 8| 7| 7| 8| 8| 5| 8| 9| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Metaplasia, Osseous | 3 |
Capsule, Inflammation, Chronic | 3 |
Pelvis, Dilatation | 2 |
Pelvis, Inflammation, Acute | 2 |
Renal Tubule, Casts Protein | 2 |
Renal Tubule, Dilatation | 2 2 1 2 1 1 1 1 1 2 2 2 1 1 |
Renal Tubule, Necrosis | 1 1 2 |
Renal Tubule, Pigmentation | 2 |
Renal Tubule, Regeneration | 2 2 1 2 1 1 2 1 2 1 |
__________________________________________________________________________|
Ureter | + |
Dilatation | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
Ectasia | 2 |
Infiltration Cellular, Lymphocyte | 2 1 2 3 2 2 2 3 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 6| 6| 5| 6| 6| 7| 6| 4| 7| 7| 6| 7| 7| 4| 5| 7| 4| 7| 4|
DAY ON TEST | 0| 0| 3| 5| 3| 2| 4| 6| 6| 9| 5| 3| 2| 5| 0| 3| 2| 3| 0| 5| 0| 3| 5| 3| 5|
| 9| 2| 0| 7| 3| 9| 1| 9| 2| 9| 9| 0| 9| 7| 8| 1| 7| 0| 9| 7| 5| 1| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 1 |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
Anorectal Junction, Inflammation, | |
Chronic Active | |
Anus, Inflammation, Acute | |
Anus, Ulcer | 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Fatty Change | 2 |
Hematopoietic Cell Proliferation | 2 2 2 1 2 1 2 2 3 2 1 2 1 |
Infiltration Cellular, Lymphocyte | 1 2 2 1 |
Necrosis | 4 2 3 |
Vacuolization Cytoplasmic | 2 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | 4 |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 1 1 2 2 2 2 2 2 |
Inflammation, Acute | |
Acinus, Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 1 2 1 2 1 2 2 1 2 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal, Squamous | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Erosion | 1 |
Hyperplasia, Focal, Squamous | 2 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 6| 6| 5| 6| 6| 7| 6| 4| 7| 7| 6| 7| 7| 4| 5| 7| 4| 7| 4|
DAY ON TEST | 0| 0| 3| 5| 3| 2| 4| 6| 6| 9| 5| 3| 2| 5| 0| 3| 2| 3| 0| 5| 0| 3| 5| 3| 5|
| 9| 2| 0| 7| 3| 9| 1| 9| 2| 9| 9| 0| 9| 7| 8| 1| 7| 0| 9| 7| 5| 1| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperplasia, Squamous | 3 3 |
Infiltration Cellular, Lymphocyte | 2 2 2 1 2 2 |
Inflammation, Acute | 3 2 1 |
Inflammation, Chronic Active | 2 |
Ulcer | 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Edema | 2 |
Erosion | 2 1 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 1 |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Mineralization | 2 |
Ulcer | |
Mucosa, Dilatation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 1 2 1 1 2 |
Inflammation, Acute | |
Inflammation, Chronic | 2 2 2 |
Atrium, Thrombosis | |
Coronary Artery, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
Capsule, Inflammation, Acute | |
Capsule, Spindle Cell, Hyperplasia | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Degeneration, Fatty | 2 2 |
Hypertrophy | |
Necrosis | 4 |
Pigmentation | 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Thrombosis | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
Necrosis | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + M M M + + + + M M + M M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 3 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 6| 6| 5| 6| 6| 7| 6| 4| 7| 7| 6| 7| 7| 4| 5| 7| 4| 7| 4|
DAY ON TEST | 0| 0| 3| 5| 3| 2| 4| 6| 6| 9| 5| 3| 2| 5| 0| 3| 2| 3| 0| 5| 0| 3| 5| 3| 5|
| 9| 2| 0| 7| 3| 9| 1| 9| 2| 9| 9| 0| 9| 7| 8| 1| 7| 0| 9| 7| 5| 1| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | X |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 3 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 3 2 2 1 |
Inflammation, Acute | 1 |
Inflammation, Chronic | 2 |
C-Cell, Hyperplasia | |
Follicle, Dilatation | 2 2 |
Follicle, Hyperplasia | 1 4 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + |
Abscess | 4 |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Acute | 4 |
Pigmentation, Hemosiderin, | |
Cholesterol | |
Follicle, Cyst | |
Follicle, Cyst Multilocular | |
Periovarian Tissue, Cyst | X X 2 X X |
__________________________________________________________________________|
Oviduct | |
Inflammation, Acute | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Endometrium, Hyperplasia, Cystic | 3 1 2 2 2 2 2 2 1 3 3 2 2 3 |
Endometrium, Inflammation, Acute | 2 3 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Fibrosis | 2 1 1 2 1 2 2 1 3 |
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 2 |
Bronchial, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 6| 6| 5| 6| 6| 7| 6| 4| 7| 7| 6| 7| 7| 4| 5| 7| 4| 7| 4|
DAY ON TEST | 0| 0| 3| 5| 3| 2| 4| 6| 6| 9| 5| 3| 2| 5| 0| 3| 2| 3| 0| 5| 0| 3| 5| 3| 5|
| 9| 2| 0| 7| 3| 9| 1| 9| 2| 9| 9| 0| 9| 7| 8| 1| 7| 0| 9| 7| 5| 1| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Congestion | 3 2 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 3 2 2 3 |
Mesenteric, Inflammation, Acute | 3 3 4 |
Renal, Congestion | 3 |
Renal, Hyperplasia, Lymphoid | 3 |
Renal, Inflammation, Acute | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Glandular | 2 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 3 2 2 2 3 |
Hyperplasia | |
Inflammation, Acute | |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | A + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 1 2 2 2 2 2 3 3 2 2 2 2 2 2 |
Hyperplasia, Lymphoid | 1 2 2 2 2 |
Infiltration Cellular | |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 |
Capsule, Inflammation, Acute | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + |
Cyst | X |
Ectopic Thyroid | X |
Edema | 3 |
Hyperplasia, Lymphoid | 2 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + |
Ectasia | 3 2 3 2 1 2 3 |
Acinus, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Alopecia | 3 1 2 3 |
Inflammation, Chronic | 2 |
Foot, Ulcer | |
Head, Ulcer | |
Inguinal, Ulcer | 4 |
Subcutaneous Tissue, Edema | 2 |
Subcutaneous Tissue, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
Femur, Fracture | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Head, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 6| 6| 5| 6| 6| 7| 6| 4| 7| 7| 6| 7| 7| 4| 5| 7| 4| 7| 4|
DAY ON TEST | 0| 0| 3| 5| 3| 2| 4| 6| 6| 9| 5| 3| 2| 5| 0| 3| 2| 3| 0| 5| 0| 3| 5| 3| 5|
| 9| 2| 0| 7| 3| 9| 1| 9| 2| 9| 9| 0| 9| 7| 8| 1| 7| 0| 9| 7| 5| 1| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Compression | X |
Hemorrhage | 1 |
Infiltration Cellular, Lymphocyte | 1 |
Mineralization | 2 3 2 2 1 2 2 2 1 2 2 2 2 2 |
Nerve, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Congestion | 3 2 2 |
Hemorrhage | 2 2 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Interstitium, Inflammation, Acute | 2 |
Interstitium, Inflammation, Chronic | 1 |
Peribronchiolar, Inflammation, Acute | |
Pleura, Inflammation, Chronic | 2 |
Pleura, Interstitium, Inflammation, | |
Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Lumen, Hemorrhage | 2 1 2 3 2 3 3 2 2 |
Mucosa, Inflammation, Acute | 1 |
Nasolacrimal Duct, Hemorrhage | |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Olfactory Epithelium, Degeneration | 2 1 1 1 2 2 2 2 2 2 2 2 2 2 1 2 |
Respiratory Epithelium, Degeneration | 2 1 2 1 1 2 |
Turbinate, Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Abscess | |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Inflammation, Chronic | |
Inflammation | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 6| 6| 5| 6| 6| 7| 6| 4| 7| 7| 6| 7| 7| 4| 5| 7| 4| 7| 4|
DAY ON TEST | 0| 0| 3| 5| 3| 2| 4| 6| 6| 9| 5| 3| 2| 5| 0| 3| 2| 3| 0| 5| 0| 3| 5| 3| 5|
| 9| 2| 0| 7| 3| 9| 1| 9| 2| 9| 9| 0| 9| 7| 8| 1| 7| 0| 9| 7| 5| 1| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Metaplasia, Osseous | |
Capsule, Inflammation, Chronic | |
Pelvis, Dilatation | |
Pelvis, Inflammation, Acute | 3 |
Renal Tubule, Casts Protein | 1 2 2 |
Renal Tubule, Dilatation | 1 2 1 2 3 2 1 2 1 2 1 2 |
Renal Tubule, Necrosis | 1 2 2 1 |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 1 2 2 2 1 1 1 1 |
__________________________________________________________________________|
Ureter | |
Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Ectasia | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 7| 7| 6| 7| 6| | |
DAY ON TEST | 0| 3| 5| 1| 5| 2| 3| 5| 2| 6| | |
| 1| 3| 0| 3| 7| 9| 2| 3| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 50 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 2 | 15 1.9|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
Anorectal Junction, Inflammation, | | |
Chronic Active | | 1 2.0|
Anus, Inflammation, Acute | | 1 4.0|
Anus, Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 50 |
Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 50 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 50 |
Amyloid Deposition | 3 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Fatty Change | | 1 2.0|
Hematopoietic Cell Proliferation | 1 2 2 2 | 30 1.8|
Infiltration Cellular, Lymphocyte | 2 2 | 15 1.9|
Necrosis | | 4 2.8|
Vacuolization Cytoplasmic | | 1 2.0|
Serosa, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Inflammation, Chronic | | 1 4.0|
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 | 25 1.8|
Inflammation, Acute | | 1 3.0|
Acinus, Atrophy | | 2 3.5|
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 1 2 2 2 1 2 2 | 33 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 7| 7| 6| 7| 6| | |
DAY ON TEST | 0| 3| 5| 1| 5| 2| 3| 5| 2| 6| | |
| 1| 3| 0| 3| 7| 9| 2| 3| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
Hyperplasia, Focal, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
Erosion | | 2 1.5|
Hyperplasia, Focal, Squamous | 4 | 2 3.0|
Hyperplasia, Squamous | 2 | 4 2.8|
Infiltration Cellular, Lymphocyte | | 8 1.9|
Inflammation, Acute | 2 | 6 2.0|
Inflammation, Chronic Active | 2 | 3 2.0|
Ulcer | 2 | 4 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 50 |
Edema | | 1 2.0|
Erosion | | 4 2.0|
Infiltration Cellular, Lymphocyte | 2 2 1 2 | 22 1.8|
Inflammation, Acute | | 2 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | | 2 1.5|
Ulcer | | 2 3.0|
Mucosa, Dilatation | 2 1 2 | 10 1.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 1 1 2 1 | 20 1.2|
Inflammation, Acute | 2 1 | 3 2.3|
Inflammation, Chronic | | 4 2.0|
Atrium, Thrombosis | | 1 4.0|
Coronary Artery, Inflammation, | | |
Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
Capsule, Inflammation, Acute | | 1 2.0|
Capsule, Spindle Cell, Hyperplasia | 3 2 2 2 2 2 2 2 2 | 49 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 50 |
Degeneration, Fatty | | 2 2.0|
Hypertrophy | 2 | 2 2.0|
Necrosis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 7| 7| 6| 7| 6| | |
DAY ON TEST | 0| 3| 5| 1| 5| 2| 3| 5| 2| 6| | |
| 1| 3| 0| 3| 7| 9| 2| 3| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pigmentation | 2 2 2 2 2 2 2 | 45 2.0|
Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 49 |
Hyperplasia | | 1 2.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M M M M M + | 18 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 49 |
Pars Distalis, Angiectasis | 2 | 2 2.5|
Pars Distalis, Cyst | X | 3 2.0|
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 2 3 2 | 14 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 8 1.9|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
C-Cell, Hyperplasia | 1 | 1 1.0|
Follicle, Dilatation | 2 | 4 2.0|
Follicle, Hyperplasia | | 7 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 50 |
Abscess | | 2 4.0|
Hemorrhage | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 1 3.0|
Inflammation, Acute | 4 | 2 4.0|
Pigmentation, Hemosiderin, | | |
Cholesterol | | 1 3.0|
Follicle, Cyst | | 1 |
Follicle, Cyst Multilocular | | 1 |
Periovarian Tissue, Cyst | | 8 2.0|
__________________________________________________________________________|____________|
Oviduct | + | 1 |
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 7| 7| 6| 7| 6| | |
DAY ON TEST | 0| 3| 5| 1| 5| 2| 3| 5| 2| 6| | |
| 1| 3| 0| 3| 7| 9| 2| 3| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 50 |
Endometrium, Hyperplasia, Cystic | 3 4 3 3 2 3 2 3 2 | 38 2.4|
Endometrium, Inflammation, Acute | 3 1 | 7 2.4|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Fibrosis | 1 3 2 2 2 3 | 26 1.8|
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 | 38 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | 3 | 2 2.5|
Bronchial, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 2 2.0|
Mediastinal, Inflammation, Acute | | 1 3.0|
Mesenteric, Congestion | | 6 2.8|
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 | 21 2.1|
Mesenteric, Inflammation, Acute | | 7 2.7|
Renal, Congestion | | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + | 50 |
Hyperplasia, Glandular | | 1 2.0|
Hyperplasia, Lymphoid | 2 2 2 3 2 | 32 2.1|
Hyperplasia | 3 | 1 3.0|
Inflammation, Acute | | 2 2.5|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 49 |
Hematopoietic Cell Proliferation | 3 2 2 3 2 2 2 | 41 2.2|
Hyperplasia, Lymphoid | 2 2 1 | 13 1.8|
Infiltration Cellular | | 1 2.0|
Pigmentation | 2 2 2 1 2 2 2 | 34 1.9|
Capsule, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M M + + | 48 |
Cyst | | 1 |
Ectopic Thyroid | | 1 |
Edema | | 1 3.0|
Hyperplasia, Lymphoid | 2 3 | 10 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 7| 7| 6| 7| 6| | |
DAY ON TEST | 0| 3| 5| 1| 5| 2| 3| 5| 2| 6| | |
| 1| 3| 0| 3| 7| 9| 2| 3| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 48 |
Ectasia | 2 2 2 2 1 | 18 2.1|
Acinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Alopecia | 2 | 8 2.3|
Inflammation, Chronic | | 1 2.0|
Foot, Ulcer | | 1 4.0|
Head, Ulcer | 3 | 1 3.0|
Inguinal, Ulcer | | 1 4.0|
Subcutaneous Tissue, Edema | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
Femur, Fracture | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Head, Inflammation, Acute | | 2 2.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
Compression | | 3 2.5|
Hemorrhage | 2 | 4 1.5|
Infiltration Cellular, Lymphocyte | | 4 1.5|
Mineralization | 2 3 2 2 | 30 2.0|
Nerve, Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Congestion | 3 2 | 9 2.2|
Hemorrhage | 2 | 7 2.0|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 | 40 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 3 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 3 2.3|
Interstitium, Inflammation, Acute | | 1 2.0|
Interstitium, Inflammation, Chronic | | 1 1.0|
Peribronchiolar, Inflammation, Acute | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 7| 7| 6| 7| 6| | |
DAY ON TEST | 0| 3| 5| 1| 5| 2| 3| 5| 2| 6| | |
| 1| 3| 0| 3| 7| 9| 2| 3| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Pleura, Inflammation, Chronic | | 1 2.0|
Pleura, Interstitium, Inflammation, | | |
Acute | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 50 |
Lumen, Hemorrhage | 3 3 2 2 | 28 2.1|
Mucosa, Inflammation, Acute | | 4 2.0|
Nasolacrimal Duct, Hemorrhage | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | 2 2 3 | 5 2.4|
Olfactory Epithelium, Degeneration | 2 1 2 2 2 2 2 2 | 41 1.8|
Respiratory Epithelium, Degeneration | 1 2 | 14 1.6|
Turbinate, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
Inflammation, Acute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Abscess | | 1 4.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 | 36 2.0|
Inflammation, Chronic | | 1 4.0|
Inflammation | | 1 4.0|
Metaplasia, Osseous | 2 2 | 3 2.3|
Capsule, Inflammation, Chronic | | 1 3.0|
Pelvis, Dilatation | | 1 2.0|
Pelvis, Inflammation, Acute | | 2 2.5|
Renal Tubule, Casts Protein | 2 | 5 1.8|
Renal Tubule, Dilatation | 1 1 1 2 | 30 1.5|
Renal Tubule, Necrosis | 2 1 | 9 1.4|
Renal Tubule, Pigmentation | | 1 2.0|
Renal Tubule, Regeneration | 1 1 1 2 2 | 23 1.4|
__________________________________________________________________________|____________|
Ureter | | 1 |
Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 50 |
Ectasia | | 2 2.0|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 | 34 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 2| 5| 3| 9| 3| 2| 3| 1| 5| 5| 3| 2| 3| 0| 5| 3| 3| 5| 2| 3| 3| 3|
| 7| 0| 2| 9| 7| 0| 4| 3| 9| 3| 6| 7| 7| 2| 9| 1| 0| 7| 2| 3| 7| 9| 3| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 3 2 1 1 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
Anorectal Junction, Ulcer | |
Anus, Erosion | 2 |
Anus, Inflammation, Acute | |
Anus, Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Necrosis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Bile Stasis | 2 |
Congestion | |
Fatty Change | 2 |
Hematopoietic Cell Proliferation | 1 2 2 2 2 3 1 2 2 2 1|
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 2 2 2 2 2|
Inflammation, Acute | 1 |
Inflammation, Chronic Active | 3 |
Necrosis | |
Vacuolization Cytoplasmic | |
Serosa, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 2 2 2 2 2 2 1 2 1 2 2|
Inflammation, Chronic Active | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Erosion | 2 |
Hyperplasia, Focal, Squamous | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 2| 5| 3| 9| 3| 2| 3| 1| 5| 5| 3| 2| 3| 0| 5| 3| 3| 5| 2| 3| 3| 3|
| 7| 0| 2| 9| 7| 0| 4| 3| 9| 3| 6| 7| 7| 2| 9| 1| 0| 7| 2| 3| 7| 9| 3| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperplasia, Squamous | 2 2 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Acute | 3 1 1 3 2 |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 2 3 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Erosion | |
Infiltration Cellular, Lymphocyte | 1 2 2 1 1 2 2 1 2 2|
Inflammation, Acute | 2 1 |
Mineralization | |
Mucosa, Dilatation | 1 1 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 1 1 1 1 |
Inflammation, Chronic | |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
Capsule, Spindle Cell, Hyperplasia | 3 3 2 3 2 2 2 2 2 2 2 3 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | |
Degeneration, Fatty | |
Hematopoietic Cell Proliferation | |
Hypertrophy, Diffuse | 2|
Hypertrophy | 2 |
Pigmentation | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2|
Spindle Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M M + + M M M M M M + M + M M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1|
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 2 |
Follicle, Dilatation | 2 2 |
Follicle, Hyperplasia | 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 2| 5| 3| 9| 3| 2| 3| 1| 5| 5| 3| 2| 3| 0| 5| 3| 3| 5| 2| 3| 3| 3|
| 7| 0| 2| 9| 7| 0| 4| 3| 9| 3| 6| 7| 7| 2| 9| 1| 0| 7| 2| 3| 7| 9| 3| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 4 |
Hyperplasia, Adenomatous | 3 |
Inflammation, Acute | 4 4 |
Mineralization | 2 |
Periovarian Tissue, Cyst | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Endometrium, Hyperplasia, Cystic | 3 2 2 3 4 2 2 2 2 3 2 2 2 2 1|
Endometrium, Inflammation, Acute | 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 2 2 1 3 2 2 2 |
Fibrous Osteodystrophy | 1|
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Lymphoid | |
Iliac, Inflammation, Acute | |
Mediastinal, Congestion | 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mesenteric, Angiectasis | 2 |
Mesenteric, Congestion | 2 2 |
Mesenteric, Hemorrhage | 4 |
Mesenteric, Hyperplasia, Lymphoid | 2 3 2 2 2 2 2 |
Mesenteric, Inflammation, Acute | 2 3 2 3 3 |
Renal, Hyperplasia, Lymphoid | |
Renal, Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 3 2 2 2 3 2 2 2 2 2 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 2 2 2 2 1 2 3 2 3 3 2 3 3 2 2 2 4 2 2|
Hyperplasia, Lymphoid | 2 2 2 2 |
Pigmentation | 1 2 2 1 2 2 2 1 2 2 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | 2 2 |
Hyperplasia, Lymphoid | 2 2 3 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 2| 5| 3| 9| 3| 2| 3| 1| 5| 5| 3| 2| 3| 0| 5| 3| 3| 5| 2| 3| 3| 3|
| 7| 0| 2| 9| 7| 0| 4| 3| 9| 3| 6| 7| 7| 2| 9| 1| 0| 7| 2| 3| 7| 9| 3| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + + + +|
Ectasia | 1 2 1 3 3 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
Cranium, Fracture | |
Cranium, Inflammation, Chronic Active| |
Femur, Fracture | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 2|
Mineralization | 2 2 2 2 2 2 2 2 2 2 2|
Hippocampus, Cyst | X |
Meninges, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 2 2|
Hemorrhage | 2 1 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Mineralization | |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 1 4 |
Interstitium, Inflammation, Acute | |
Pleura, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 4 2 2 1 2 2 2 1 2 2 |
Mucosa, Inflammation, Acute | |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 3 |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 1 2 2 1 2 2 |
Olfactory Epithelium, Inflammation, | |
Acute | 2 |
Olfactory Epithelium, Metaplasia | 1|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 4| 7| 7| 7| 4| 4| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 2| 5| 3| 9| 3| 2| 3| 1| 5| 5| 3| 2| 3| 0| 5| 3| 3| 5| 2| 3| 3| 3|
| 7| 0| 2| 9| 7| 0| 4| 3| 9| 3| 6| 7| 7| 2| 9| 1| 0| 7| 2| 3| 7| 9| 3| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Degeneration | 2 2 1 2 |
Respiratory Epithelium, Inflammation,| |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Glands, Inflammation, Acute | |
Lumen, Hemorrhage | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + |
Hyperplasia | 2 |
Inflammation, Acute | 4 |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infarct | 4 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 |
Inflammation, Acute | |
Metaplasia, Osseous | 2 2 |
Regeneration | |
Renal Tubule, Casts Protein | 1 1 1|
Renal Tubule, Dilatation | 2 1 1 1 1 2 2 1 1|
Renal Tubule, Necrosis | 1 1 1 |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 2 1 1 2 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 5| 7| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 7| 7| 5| 5| 7| 4|
DAY ON TEST | 2| 2| 7| 5| 3| 3| 3| 3| 8| 3| 3| 2| 8| 2| 3| 3| 5| 3| 3| 2| 3| 2| 9| 1| 8|
| 3| 9| 0| 7| 3| 2| 1| 1| 2| 0| 1| 9| 9| 1| 1| 1| 7| 2| 2| 9| 3| 0| 8| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + A + M + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 1 2 2 2 2 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + |
Anorectal Junction, Ulcer | 3 |
Anus, Erosion | |
Anus, Inflammation, Acute | 2 |
Anus, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + |
Diverticulum | 4 |
Necrosis | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Bile Stasis | |
Congestion | 4 |
Fatty Change | 2 |
Hematopoietic Cell Proliferation | 2 2 4 2 2 2 2 2 2 2 2 1 |
Infiltration Cellular, Lymphocyte | 2 1 3 2 2 2 2 2 2 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Necrosis | 3 2 2 2 |
Vacuolization Cytoplasmic | |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 1 2 2 1 2 2 |
Inflammation, Chronic Active | 2 |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + M + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 3 2 2 2 2 2 2 2 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Erosion | 2 |
Hyperplasia, Focal, Squamous | 4 3 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 5| 7| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 7| 7| 5| 5| 7| 4|
DAY ON TEST | 2| 2| 7| 5| 3| 3| 3| 3| 8| 3| 3| 2| 8| 2| 3| 3| 5| 3| 3| 2| 3| 2| 9| 1| 8|
| 3| 9| 0| 7| 3| 2| 1| 1| 2| 0| 1| 9| 9| 1| 1| 1| 7| 2| 2| 9| 3| 0| 8| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperplasia, Squamous | 3 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 |
Inflammation, Acute | 3 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
Ulcer | 3 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + |
Erosion | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 1 2 2 1 2 2 |
Inflammation, Acute | |
Mineralization | 2 |
Mucosa, Dilatation | 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 1 1 2 2 2 2 1 2 1 |
Inflammation, Chronic | 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + |
Capsule, Spindle Cell, Hyperplasia | 2 2 2 2 3 3 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Cyst | X |
Degeneration, Fatty | |
Hematopoietic Cell Proliferation | 2 |
Hypertrophy, Diffuse | |
Hypertrophy | 2 2 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M M + M + M M + M M M M M M M + M M + M + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Hyperplasia | 2 2 2 2 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 1 3 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | 1 |
Follicle, Dilatation | 2 3 2 |
Follicle, Hyperplasia | 2 2 1 2 3 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 5| 7| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 7| 7| 5| 5| 7| 4|
DAY ON TEST | 2| 2| 7| 5| 3| 3| 3| 3| 8| 3| 3| 2| 8| 2| 3| 3| 5| 3| 3| 2| 3| 2| 9| 1| 8|
| 3| 9| 0| 7| 3| 2| 1| 1| 2| 0| 1| 9| 9| 1| 1| 1| 7| 2| 2| 9| 3| 0| 8| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Hyperplasia, Adenomatous | |
Inflammation, Acute | 4 4 |
Mineralization | |
Periovarian Tissue, Cyst | X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Endometrium, Hyperplasia, Cystic | 3 3 2 2 3 2 3 2 3 2 3 3 3 2 1 2 2 2 2 |
Endometrium, Inflammation, Acute | 4 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + |
Fibrosis | 1 3 2 3 1 3 2 2 3 3 |
Fibrous Osteodystrophy | 3 2 |
Myeloid Cell, Hyperplasia | 2 2 2 3 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
Axillary, Hyperplasia, Lymphoid | 2 |
Iliac, Hyperplasia, Lymphoid | 2 3 |
Iliac, Inflammation, Acute | 4 |
Mediastinal, Congestion | 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 2 2 2 |
Mesenteric, Angiectasis | |
Mesenteric, Congestion | 2 3 2 3 3 |
Mesenteric, Hemorrhage | |
Mesenteric, Hyperplasia, Lymphoid | 2 3 2 2 2 2 2 2 2 3 2 2 2 |
Mesenteric, Inflammation, Acute | 2 4 |
Renal, Hyperplasia, Lymphoid | 3 |
Renal, Inflammation, Acute | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + M + + + + + + + + + + + + M + |
Congestion | 3 |
Hyperplasia, Lymphoid | 2 2 3 2 2 2 2 2 3 2 |
Inflammation, Acute | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 3 |
Hematopoietic Cell Proliferation | 2 2 3 2 2 3 2 2 3 2 3 2 2 3 2 3 2 2 2 3 3 |
Hyperplasia, Lymphoid | 2 2 3 2 2 2 3 2 3 |
Pigmentation | 2 1 2 2 2 2 2 2 2 2 2 2 2 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Cyst | |
Hyperplasia, Lymphoid | 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 5| 7| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 7| 7| 5| 5| 7| 4|
DAY ON TEST | 2| 2| 7| 5| 3| 3| 3| 3| 8| 3| 3| 2| 8| 2| 3| 3| 5| 3| 3| 2| 3| 2| 9| 1| 8|
| 3| 9| 0| 7| 3| 2| 1| 1| 2| 0| 1| 9| 9| 1| 1| 1| 7| 2| 2| 9| 3| 0| 8| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + |
Ectasia | 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + |
Alopecia | 2 3 |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Inflammation, | |
Acute | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + |
Cranium, Fracture | |
Cranium, Inflammation, Chronic Active| 3 |
Femur, Fracture | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + |
Compression | |
Hemorrhage | 2 |
Infiltration Cellular, Lymphocyte | 2 2 |
Mineralization | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 |
Hippocampus, Cyst | |
Meninges, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 2 2 2 |
Hemorrhage | 2 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 |
Mineralization | 1 |
Alveolar Epithelium, Hyperplasia | 3 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 2 |
Interstitium, Inflammation, Acute | 2 |
Pleura, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + |
Lumen, Hemorrhage | 1 1 3 3 1 2 2 3 2 2 2 |
Mucosa, Inflammation, Acute | 2 1 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 1 2 2 2 2 2 2 |
Olfactory Epithelium, Inflammation, | |
Acute | 1 1 |
Olfactory Epithelium, Metaplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 5| 7| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 5| 6| 7| 7| 4| 7| 7| 7| 7| 5| 5| 7| 4|
DAY ON TEST | 2| 2| 7| 5| 3| 3| 3| 3| 8| 3| 3| 2| 8| 2| 3| 3| 5| 3| 3| 2| 3| 2| 9| 1| 8|
| 3| 9| 0| 7| 3| 2| 1| 1| 2| 0| 1| 9| 9| 1| 1| 1| 7| 2| 2| 9| 3| 0| 8| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Degeneration | 1 1 2 2 2 2 2 |
Respiratory Epithelium, Inflammation,| |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Glands, Inflammation, Acute | 2 |
Lumen, Hemorrhage | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Hyperplasia | |
Inflammation, Acute | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Infarct | |
Infiltration Cellular, Lymphocyte | 2 2 2 3 2 2 2 2 1 2 2 2 2 2 2 1 2 2 |
Inflammation, Acute | 1 |
Metaplasia, Osseous | 3 2 |
Regeneration | 2 |
Renal Tubule, Casts Protein | 1 2 1 2 1 2 1 1 2 |
Renal Tubule, Dilatation | 1 1 2 2 1 2 1 1 2 2 1 2 1 2 2 |
Renal Tubule, Necrosis | 1 3 2 |
Renal Tubule, Pigmentation | 2 |
Renal Tubule, Regeneration | 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Infiltration Cellular, Lymphocyte | 2 2 3 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 7| 4| 4| 6| 0| 7| 7| | |
DAY ON TEST | 8| 8| 2| 0| 5| 5| 9| 0| 3| 3| | |
| 8| 8| 9| 9| 7| 7| 6| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + | 45 |
Infiltration Cellular, Lymphocyte | 2 2 | 16 1.8|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 47 |
Anorectal Junction, Ulcer | | 1 3.0|
Anus, Erosion | | 1 2.0|
Anus, Inflammation, Acute | | 1 2.0|
Anus, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M + + | 45 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 47 |
Amyloid Deposition | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 47 |
Diverticulum | | 1 4.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + | 47 |
Bile Stasis | | 1 2.0|
Congestion | | 1 4.0|
Fatty Change | 1 | 3 1.7|
Hematopoietic Cell Proliferation | 1 2 1 | 26 1.9|
Infiltration Cellular, Lymphocyte | 1 | 21 1.9|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic Active | | 1 3.0|
Necrosis | | 4 2.3|
Vacuolization Cytoplasmic | 2 | 1 2.0|
Serosa, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 47 |
Infiltration Cellular, Lymphocyte | 2 2 | 26 1.8|
Inflammation, Chronic Active | | 1 2.0|
Acinus, Atrophy | 3 | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 46 |
Infiltration Cellular, Lymphocyte | 1 2 1 2 2 | 32 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 7| 4| 4| 6| 0| 7| 7| | |
DAY ON TEST | 8| 8| 2| 0| 5| 5| 9| 0| 3| 3| | |
| 8| 8| 9| 9| 7| 7| 6| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + | 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 47 |
Angiectasis | | 1 3.0|
Erosion | | 2 2.0|
Hyperplasia, Focal, Squamous | | 2 3.5|
Hyperplasia, Squamous | | 4 2.3|
Infiltration Cellular, Lymphocyte | | 5 1.8|
Inflammation, Acute | | 7 2.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Chronic Active | | 3 2.0|
Ulcer | | 4 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 47 |
Erosion | 2 | 2 2.0|
Infiltration Cellular, Lymphocyte | 1 1 | 23 1.6|
Inflammation, Acute | | 2 1.5|
Mineralization | 1 | 2 1.5|
Mucosa, Dilatation | | 14 1.9|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + | 47 |
__________________________________________________________________________|____________|
Heart | + + + + + + | 47 |
Infiltration Cellular, Lymphocyte | 1 1 | 18 1.3|
Inflammation, Chronic | | 1 2.0|
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 47 |
Capsule, Spindle Cell, Hyperplasia | 2 2 2 2 2 2 | 45 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 47 |
Congestion | | 1 2.0|
Cyst | | 1 |
Degeneration, Fatty | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hypertrophy, Diffuse | | 1 2.0|
Hypertrophy | 2 | 4 2.0|
Pigmentation | 2 2 2 2 | 37 2.0|
Spindle Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 47 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 7| 4| 4| 6| 0| 7| 7| | |
DAY ON TEST | 8| 8| 2| 0| 5| 5| 9| 0| 3| 3| | |
| 8| 8| 9| 9| 7| 7| 6| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + + | 14 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 46 |
Pars Distalis, Hyperplasia | 2 2 3 | 15 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 47 |
Infiltration Cellular, Lymphocyte | | 6 1.5|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | 2 | 3 1.7|
Follicle, Dilatation | | 5 2.2|
Follicle, Hyperplasia | 4 | 10 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + | 47 |
Hemorrhage | | 2 4.0|
Hyperplasia, Adenomatous | | 1 3.0|
Inflammation, Acute | | 4 4.0|
Mineralization | | 1 2.0|
Periovarian Tissue, Cyst | | 7 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + | 47 |
Angiectasis | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 2 | 38 2.3|
Endometrium, Inflammation, Acute | 4 | 6 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 47 |
Fibrosis | 3 1 3 | 21 2.3|
Fibrous Osteodystrophy | 2 | 4 2.0|
Myeloid Cell, Hyperplasia | 2 2 2 2 | 34 2.1|
__________________________________________________________________________|____________|
Lymph Node | + + + M + + | 46 |
Axillary, Hyperplasia, Lymphoid | | 1 2.0|
Iliac, Hyperplasia, Lymphoid | | 2 2.5|
Iliac, Inflammation, Acute | | 1 4.0|
Mediastinal, Congestion | | 2 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 5 2.0|
Mesenteric, Angiectasis | | 1 2.0|
Mesenteric, Congestion | | 7 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 7| 4| 4| 6| 0| 7| 7| | |
DAY ON TEST | 8| 8| 2| 0| 5| 5| 9| 0| 3| 3| | |
| 8| 8| 9| 9| 7| 7| 6| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mesenteric, Hemorrhage | | 1 4.0|
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 4 | 24 2.2|
Mesenteric, Inflammation, Acute | | 7 2.7|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + | 43 |
Congestion | | 1 3.0|
Hyperplasia, Lymphoid | 2 2 2 4 | 25 2.2|
Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 47 |
Angiectasis | | 1 3.0|
Hematopoietic Cell Proliferation | 3 2 2 2 2 | 45 2.3|
Hyperplasia, Lymphoid | 4 | 14 2.4|
Pigmentation | 1 2 1 | 28 1.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 47 |
Congestion | | 1 2.0|
Cyst | | 2 2.0|
Hyperplasia, Lymphoid | 2 4 | 10 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 46 |
Ectasia | 2 2 | 11 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + | 47 |
Alopecia | | 2 2.5|
Subcutaneous Tissue, Edema | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 47 |
Cranium, Fracture | X | 1 |
Cranium, Inflammation, Chronic Active| | 1 3.0|
Femur, Fracture | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 47 |
Compression | | 1 3.0|
Hemorrhage | 2 | 2 2.0|
Infiltration Cellular, Lymphocyte | | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 7| 4| 4| 6| 0| 7| 7| | |
DAY ON TEST | 8| 8| 2| 0| 5| 5| 9| 0| 3| 3| | |
| 8| 8| 9| 9| 7| 7| 6| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Mineralization | 2 2 | 28 2.0|
Hippocampus, Cyst | | 1 |
Meninges, Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 47 |
Congestion | | 8 2.1|
Hemorrhage | 4 1 | 6 2.0|
Infiltration Cellular, Lymphocyte | 2 2 2 1 2 2 | 43 2.0|
Mineralization | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 4 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 7 1.9|
Interstitium, Inflammation, Acute | | 1 2.0|
Pleura, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 47 |
Lumen, Hemorrhage | 2 1 2 2 | 25 2.0|
Mucosa, Inflammation, Acute | 2 | 6 1.3|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 2 2.5|
Olfactory Epithelium, Degeneration | 2 2 2 2 | 31 1.9|
Olfactory Epithelium, Inflammation, | | |
Acute | | 3 1.3|
Olfactory Epithelium, Metaplasia | 2 | 3 2.0|
Respiratory Epithelium, Degeneration | 2 | 12 1.8|
Respiratory Epithelium, Inflammation,| | |
Acute | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 47 |
Hemorrhage | | 1 3.0|
Glands, Inflammation, Acute | | 1 2.0|
Lumen, Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
Hyperplasia | | 1 2.0|
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 7| 4| 4| 6| 0| 7| 7| | |
DAY ON TEST | 8| 8| 2| 0| 5| 5| 9| 0| 3| 3| | |
| 8| 8| 9| 9| 7| 7| 6| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 47 |
Congestion | | 1 2.0|
Infarct | | 1 4.0|
Infiltration Cellular, Lymphocyte | 1 2 2 2 | 38 2.0|
Inflammation, Acute | | 1 1.0|
Metaplasia, Osseous | | 4 2.3|
Regeneration | | 1 2.0|
Renal Tubule, Casts Protein | | 12 1.3|
Renal Tubule, Dilatation | | 24 1.5|
Renal Tubule, Necrosis | | 6 1.5|
Renal Tubule, Pigmentation | | 1 2.0|
Renal Tubule, Regeneration | | 15 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 47 |
Angiectasis | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 2 | 35 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 4| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 5| 4| 5| 9| 8| 5| 5| 3| 5| 2| 3| 3| 3| 7|
| 0| 1| 1| 3| 3| 0| 9| 3| 9| 3| 1| 7| 6| 7| 0| 6| 7| 7| 2| 7| 9| 1| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
120 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Cyst | X |
Hematopoietic Cell Proliferation | 1 2 1 1 2 1 1 2 1 |
Hyperplasia, Lymphoid | |
Hyperplasia | 3 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 |
Inflammation, Chronic | 3 |
Necrosis | 3 3|
Median Lobe, Angiectasis | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Lymphocyte | 2 2 1 2 1 1 2 2 2 2 2 2 2 |
Inflammation, Acute | |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Hyperplasia, Focal, Squamous | 3 |
Hyperplasia, Squamous | 3 2 2 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Acute | 1 |
Inflammation, Chronic Active | 3 2 2 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 4| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 5| 4| 5| 9| 8| 5| 5| 3| 5| 2| 3| 3| 3| 7|
| 0| 1| 1| 3| 3| 0| 9| 3| 9| 3| 1| 7| 6| 7| 0| 6| 7| 7| 2| 7| 9| 1| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
120 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 |
Inflammation, Acute | 2 |
Metaplasia, Squamous | |
Mineralization | |
Mucosa, Dilatation | 1 2 |
__________________________________________________________________________|
Tooth | + |
Pulp, Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2|
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 2 |
Inflammation, Chronic | |
Mineralization | |
Coronary Artery, Inflammation, Acute | |
Coronary Artery, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
Capsule, Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 4 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 3 1 3 3 |
Hypertrophy | 2 2 |
Pigmentation | 3 2 3 2 2 2 2 2 2 2 2 2 2 2 2 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M M M + M M M M M M M M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 3 2 3 2 3 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 1 |
Inflammation, Acute | 1 |
Inflammation, Chronic Active | |
Follicle, Dilatation | 2 2 2 |
Follicle, Hyperplasia | 1 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 4| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 5| 4| 5| 9| 8| 5| 5| 3| 5| 2| 3| 3| 3| 7|
| 0| 1| 1| 3| 3| 0| 9| 3| 9| 3| 1| 7| 6| 7| 0| 6| 7| 7| 2| 7| 9| 1| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
120 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Periovarian Tissue, Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Endometrium, Hyperplasia, Cystic | 3 3 2 2 2 3 3 4 2 3 3 2 2 3 4 2 2 2 |
Endometrium, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 1 1 1 3 4 2 2 3 2 2 1 2 3 2 |
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Mesenteric, Congestion | 2 4 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 2 2|
Mesenteric, Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 |
Hyperplasia | 2 |
Inflammation, Acute | 2 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 3 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 |
Pigmentation | 1 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + +|
Congestion | |
Cyst | |
Hyperplasia, Lymphoid | 2 2 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 2 2 2 2 2 2 2 2 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 3 2|
Back, Ulcer | |
Subcutaneous Tissue, Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 4| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 5| 4| 5| 9| 8| 5| 5| 3| 5| 2| 3| 3| 3| 7|
| 0| 1| 1| 3| 3| 0| 9| 3| 9| 3| 1| 7| 6| 7| 0| 6| 7| 7| 2| 7| 9| 1| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
120 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Femur, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Mineralization | 2 2 2 2 1 2 2 2 1 1 2 2|
Meninges, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Mineralization | 1 1 |
Alveolar Epithelium, Hyperplasia | 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
Interstitium, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 2 2 2 2 2 2 2 2 2 2 2 1 |
Mucosa, Inflammation, Acute | 1 |
Nasolacrimal Duct, Hemorrhage | |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Olfactory Epithelium, Degeneration | 2 1 1 2 2 1 2 2 2 2 2 2 2 |
Olfactory Epithelium, Inflammation, | |
Acute | 1 |
Respiratory Epithelium, Degeneration | 1 2 2 2 2 2 2 |
Turbinate, Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 4| 6| 6| 4| 4| 7| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 5| 4| 5| 9| 8| 5| 5| 3| 5| 2| 3| 3| 3| 7|
| 0| 1| 1| 3| 3| 0| 9| 3| 9| 3| 1| 7| 6| 7| 0| 6| 7| 7| 2| 7| 9| 1| 0| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
120 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Metaplasia, Osseous | |
Mineralization | |
Pelvis, Dilatation | |
Renal Tubule, Casts Protein | 2 1 2 1 2 |
Renal Tubule, Dilatation | 2 1 1 2 1 2 2 2 |
Renal Tubule, Necrosis | 2 1 2 |
Renal Tubule, Pigmentation | 2 |
Renal Tubule, Regeneration | 3 1 2 2 1 |
__________________________________________________________________________|
Ureter | |
Dilatation | |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 1 2 2 3 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 4| 4| 5| 7| 4| 4| 7| 5| 7| 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3|
DAY ON TEST | 3| 5| 5| 9| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 5| 3| 2| 3| 3| 3| 3| 2| 2| 8| 8|
| 1| 7| 2| 9| 0| 7| 7| 2| 4| 1| 0| 2| 3| 3| 7| 2| 9| 0| 2| 1| 3| 9| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
120 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 1 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Cyst | |
Hematopoietic Cell Proliferation | 2 2 1 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia | |
Infiltration Cellular, Lymphocyte | 1 2 2 2 2 |
Inflammation, Chronic | |
Necrosis | 2 |
Median Lobe, Angiectasis | 2 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 1 2|
Inflammation, Acute | 2 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + M + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia, Focal, Squamous | 3 |
Hyperplasia, Squamous | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 4| 4| 5| 7| 4| 4| 7| 5| 7| 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3|
DAY ON TEST | 3| 5| 5| 9| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 5| 3| 2| 3| 3| 3| 3| 2| 2| 8| 8|
| 1| 7| 2| 9| 0| 7| 7| 2| 4| 1| 0| 2| 3| 3| 7| 2| 9| 0| 2| 1| 3| 9| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
120 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 2 1 2 2 2 2 2 2 2 |
Inflammation, Acute | 2 |
Metaplasia, Squamous | 2 |
Mineralization | 1 |
Mucosa, Dilatation | 1 1 2 2 |
__________________________________________________________________________|
Tooth | |
Pulp, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 1|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Infiltration Cellular, Lymphocyte | 1 1 1 1 2 |
Inflammation, Chronic | |
Mineralization | 1 |
Coronary Artery, Inflammation, Acute | |
Coronary Artery, Inflammation, | |
Chronic | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
Capsule, Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 2 |
Hypertrophy | |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | M M M M M M + + M + M M M M M + M M M + M|
__________________________________________________________________________|
Pituitary Gland | + M + + + M + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X|
Pars Distalis, Hyperplasia | 4 2 3 3 2 2 2 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | 3 |
Follicle, Dilatation | 3 |
Follicle, Hyperplasia | 2 1 3 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 4| 4| 5| 7| 4| 4| 7| 5| 7| 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3|
DAY ON TEST | 3| 5| 5| 9| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 5| 3| 2| 3| 3| 3| 3| 2| 2| 8| 8|
| 1| 7| 2| 9| 0| 7| 7| 2| 4| 1| 0| 2| 3| 3| 7| 2| 9| 0| 2| 1| 3| 9| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
120 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + M + + + + + + + + + + + + + +|
Periovarian Tissue, Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Endometrium, Hyperplasia, Cystic | 2 2 2 3 3 2 3 2 2 2 2 2 2 2 2 2 3 2 2|
Endometrium, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 2 2 3 2 2 2 2 2 2 2 2 2 |
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mesenteric, Congestion | 2 2 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 3 2 2 2 2 2 |
Mesenteric, Inflammation, Acute | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 |
Hyperplasia | |
Inflammation, Acute | 2 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 3 3 2 2 2 2 2 2 2 2 2 2 2 |
Hyperplasia, Lymphoid | 3 2 2 2 2 2 |
Pigmentation | 2 2 2 2 2 2 2 2 2 1 1 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | 2 |
Hyperplasia, Lymphoid | 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 3 2 3 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 2 3 3 2 |
Back, Ulcer | 3 |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 4| 4| 5| 7| 4| 4| 7| 5| 7| 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3|
DAY ON TEST | 3| 5| 5| 9| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 5| 3| 2| 3| 3| 3| 3| 2| 2| 8| 8|
| 1| 7| 2| 9| 0| 7| 7| 2| 4| 1| 0| 2| 3| 3| 7| 2| 9| 0| 2| 1| 3| 9| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
120 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Femur, Fracture | X |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 |
Mineralization | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Meninges, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 2 1 2 2 |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2|
Mineralization | 2 1 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 4 |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 2 2 2 2 2 2 2 2 2 2 2 2 1|
Mucosa, Inflammation, Acute | |
Nasolacrimal Duct, Hemorrhage | 1 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 2 2 2 2 2 2 1 2|
Olfactory Epithelium, Inflammation, | |
Acute | |
Respiratory Epithelium, Degeneration | 1 2 2 2 1 1 2 2 |
Turbinate, Inflammation, Acute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 4| 4| 5| 7| 4| 4| 7| 5| 7| 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3|
DAY ON TEST | 3| 5| 5| 9| 3| 5| 5| 3| 3| 3| 3| 3| 3| 8| 5| 3| 2| 3| 3| 3| 3| 2| 2| 8| 8|
| 1| 7| 2| 9| 0| 7| 7| 2| 4| 1| 0| 2| 3| 3| 7| 2| 9| 0| 2| 1| 3| 9| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
120 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2 2|
Metaplasia, Osseous | |
Mineralization | |
Pelvis, Dilatation | |
Renal Tubule, Casts Protein | 1 1 2 2 1 2 |
Renal Tubule, Dilatation | 1 2 1 2 2 1 1 2 |
Renal Tubule, Necrosis | 1 2 |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 1 2 1 1 1 1 |
__________________________________________________________________________|
Ureter | |
Dilatation | |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 3| 7| 4| 6| 7| 4| 0| 7| 6| 7| | |
DAY ON TEST | 8| 3| 5| 5| 3| 5| 0| 3| 8| 3| | |
| 8| 2| 7| 3| 0| 8| 8| 2| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
120 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 | 2 2.0|
__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + | 49 |
Infiltration Cellular, Lymphocyte | 2 2 | 18 1.9|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 50 |
Amyloid Deposition | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Basophilic Focus | | 3 |
Cyst | | 1 |
Hematopoietic Cell Proliferation | 1 2 1 2 | 16 1.4|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia | | 1 3.0|
Infiltration Cellular, Lymphocyte | 2 2 2 | 16 1.9|
Inflammation, Chronic | | 1 3.0|
Necrosis | 2 | 4 2.5|
Median Lobe, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 2 2 2 | 28 1.8|
Inflammation, Acute | | 1 2.0|
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
Atrophy | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 2 2 2 | 37 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 49 |
Erosion | | 1 3.0|
Hyperplasia, Focal, Squamous | 3 | 3 3.0|
Hyperplasia, Squamous | 3 2 | 6 2.3|
Infiltration Cellular, Lymphocyte | | 6 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 3| 7| 4| 6| 7| 4| 0| 7| 6| 7| | |
DAY ON TEST | 8| 3| 5| 5| 3| 5| 0| 3| 8| 3| | |
| 8| 2| 7| 3| 0| 8| 8| 2| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
120 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Acute | 2 | 2 1.5|
Inflammation, Chronic Active | | 4 2.3|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 50 |
Erosion | 2 | 4 2.0|
Infiltration Cellular, Lymphocyte | 2 2 2 | 18 1.9|
Inflammation, Acute | | 2 2.0|
Metaplasia, Squamous | | 1 2.0|
Mineralization | | 1 1.0|
Mucosa, Dilatation | | 6 1.5|
__________________________________________________________________________|____________|
Tooth | | 1 |
Pulp, Inflammation, Acute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + | 50 |
Aorta, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Fibrosis, Focal | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 1 | 13 1.2|
Inflammation, Chronic | 2 | 1 2.0|
Mineralization | | 1 1.0|
Coronary Artery, Inflammation, Acute | 3 | 1 3.0|
Coronary Artery, Inflammation, | | |
Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
Capsule, Spindle Cell, Hyperplasia | 2 2 2 2 2 1 2 2 2 | 50 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 50 |
Degeneration, Fatty | 1 2 | 9 2.1|
Hypertrophy | | 2 2.0|
Pigmentation | 2 2 2 2 2 3 | 37 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + | 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M M M M M M | 12 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 48 |
Pars Distalis, Cyst | | 3 |
Pars Distalis, Hyperplasia | 2 | 18 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 3| 7| 4| 6| 7| 4| 0| 7| 6| 7| | |
DAY ON TEST | 8| 3| 5| 5| 3| 5| 0| 3| 8| 3| | |
| 8| 2| 7| 3| 0| 8| 8| 2| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
120 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 | 6 1.8|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic Active | | 1 3.0|
Follicle, Dilatation | 2 | 5 2.2|
Follicle, Hyperplasia | 2 1 2 | 13 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 49 |
Periovarian Tissue, Cyst | X | 8 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 50 |
Angiectasis | | 2 2.5|
Endometrium, Hyperplasia, Cystic | 3 2 2 4 2 2 | 43 2.4|
Endometrium, Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Fibrosis | 2 2 2 | 32 2.1|
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 | 35 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + M + + + | 49 |
Hyperplasia, Lymphoid | 2 | 2 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mesenteric, Congestion | 2 | 5 2.4|
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 | 17 2.1|
Mesenteric, Inflammation, Acute | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + | 48 |
Hyperplasia, Lymphoid | 2 2 2 2 2 | 29 2.0|
Hyperplasia | | 1 2.0|
Inflammation, Acute | | 2 2.0|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 1 | 39 2.1|
Hyperplasia, Lymphoid | | 16 2.1|
Pigmentation | 2 2 2 2 2 2 1 | 33 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 3| 7| 4| 6| 7| 4| 0| 7| 6| 7| | |
DAY ON TEST | 8| 3| 5| 5| 3| 5| 0| 3| 8| 3| | |
| 8| 2| 7| 3| 0| 8| 8| 2| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
120 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + | 48 |
Congestion | | 1 2.0|
Cyst | | 1 2.0|
Hyperplasia, Lymphoid | | 6 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 50 |
Ectasia | 2 2 2 | 18 2.3|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Alopecia | 3 | 9 2.4|
Back, Ulcer | | 1 3.0|
Subcutaneous Tissue, Hemorrhage | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 49 |
Femur, Fracture | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 3 2.0|
Mineralization | 2 2 2 3 | 31 1.9|
Meninges, Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Congestion | 2 3 | 2 2.5|
Hemorrhage | 2 2 | 8 1.9|
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 | 42 2.0|
Mineralization | 1 2 | 7 1.3|
Alveolar Epithelium, Hyperplasia | | 3 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 3.5|
Interstitium, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 50 |
Lumen, Hemorrhage | 2 2 2 | 28 1.9|
Mucosa, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 3| 7| 4| 6| 7| 4| 0| 7| 6| 7| | |
DAY ON TEST | 8| 3| 5| 5| 3| 5| 0| 3| 8| 3| | |
| 8| 2| 7| 3| 0| 8| 8| 2| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
120 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Hemorrhage | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
Olfactory Epithelium, Degeneration | 2 2 2 2 | 31 1.9|
Olfactory Epithelium, Inflammation, | | |
Acute | | 1 1.0|
Respiratory Epithelium, Degeneration | 2 2 1 2 | 19 1.7|
Turbinate, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Abscess | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 | 42 1.9|
Metaplasia, Osseous | 2 | 1 2.0|
Mineralization | 3 | 1 3.0|
Pelvis, Dilatation | 3 | 1 3.0|
Renal Tubule, Casts Protein | | 11 1.5|
Renal Tubule, Dilatation | | 16 1.6|
Renal Tubule, Necrosis | 2 1 | 7 1.6|
Renal Tubule, Pigmentation | | 1 2.0|
Renal Tubule, Regeneration | 2 1 | 13 1.5|
__________________________________________________________________________|____________|
Ureter | + | 1 |
Dilatation | 3 | 1 3.0|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 50 |
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 | 39 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 2| 5| 6| 4| 4| 5| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 5| 5| 5| 7|
DAY ON TEST | 4| 2| 3| 4| 3| 9| 5| 6| 3| 3| 4| 2| 0| 2| 3| 3| 3| 0| 2| 7| 3| 3| 4| 4| 2|
| 6| 9| 1| 3| 1| 1| 7| 9| 8| 4| 9| 9| 8| 9| 3| 3| 2| 1| 9| 6| 1| 4| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
Cyst | |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Acute | 3 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 4 4 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bile Stasis | 2 |
Focal Cellular Change | X |
Hematopoietic Cell Proliferation | 2 2 2 2 2 3 2 |
Infarct | 2 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic | |
Necrosis | 3 4 2 |
Centrilobular, Fatty Change | 1 |
Periportal, Inflammation, Chronic | 2 2 |
__________________________________________________________________________|
Mesentery | + |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 1 2 2 |
Acinus, Atrophy | 3 |
Acinus, Hyperplasia | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hyperplasia, Glandular | |
Infiltration Cellular, Lymphocyte | 2 2 1 1 2 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Acute | 3 2 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 2| 5| 6| 4| 4| 5| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 5| 5| 5| 7|
DAY ON TEST | 4| 2| 3| 4| 3| 9| 5| 6| 3| 3| 4| 2| 0| 2| 3| 3| 3| 0| 2| 7| 3| 3| 4| 4| 2|
| 6| 9| 1| 3| 1| 1| 7| 9| 8| 4| 9| 9| 8| 9| 3| 3| 2| 1| 9| 6| 1| 4| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 3 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2|
Inflammation, Acute | 3 2 |
Inflammation, Chronic Active | |
Mucosa, Dilatation | 2|
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Tooth | |
Pulp, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + M + + +|
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1|
Inflammation, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Spindle Cell, Hyperplasia | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 2|
Pigmentation | 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + M M M + M + M M + + + + M M M M M M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 2 |
Follicle, Cyst | |
Follicle, Dilatation | 2 |
Follicle, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 2| 5| 6| 4| 4| 5| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 5| 5| 5| 7|
DAY ON TEST | 4| 2| 3| 4| 3| 9| 5| 6| 3| 3| 4| 2| 0| 2| 3| 3| 3| 0| 2| 7| 3| 3| 4| 4| 2|
| 6| 9| 1| 3| 1| 1| 7| 9| 8| 4| 9| 9| 8| 9| 3| 3| 2| 1| 9| 6| 1| 4| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 1 2 2 2 2 |
__________________________________________________________________________|
Penis | + + + + + |
Concretion | |
Inflammation, Acute | 4 4 4 3 4 |
Inflammation | |
__________________________________________________________________________|
Preputial Gland | + + + |
Abscess | 4 |
Cyst | 3 |
Inflammation, Acute | |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 |
Inflammation, Acute | 2 4 3 4 2 4 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 3 |
Granuloma Sperm | |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 2 |
Interstitial Cell, Hyperplasia | 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 3 2 2 2 3 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Lymphoid | 2 |
Iliac, Hyperplasia, Lymphoid | 2 |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | 2|
Mesenteric, Congestion | 2 3 3 2 2 2 |
Mesenteric, Hemorrhage | 3 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 3 4 2 2 2 2 2 2|
Mesenteric, Inflammation, Acute | 3 3 |
Renal, Congestion | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M M M + + + + + + + + + + M +|
Hyperplasia, Lymphoid | 1 2 2 2 2 2 2 2 2 2 2 |
Inflammation, Acute | |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 2| 5| 6| 4| 4| 5| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 5| 5| 5| 7|
DAY ON TEST | 4| 2| 3| 4| 3| 9| 5| 6| 3| 3| 4| 2| 0| 2| 3| 3| 3| 0| 2| 7| 3| 3| 4| 4| 2|
| 6| 9| 1| 3| 1| 1| 7| 9| 8| 4| 9| 9| 8| 9| 3| 3| 2| 1| 9| 6| 1| 4| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 2 2 2 2 2 3 1 2 3 3 2 3 2 3 2 4 1 2 2 2 2 2|
Hyperplasia, Lymphoid | 2 3 2 2 |
Pigmentation | 1 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + M + + + M + + +|
Cyst | X 2 X |
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M M M M M M M M M M + M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 |
Inflammation, Acute | |
Inflammation, Chronic | |
Ulcer | |
Head, Inflammation, Acute | |
Head, Inflammation, Chronic | 2 |
Inguinal, Abscess | |
Inguinal, Ulcer | |
Prepuce, Abscess | 4 |
Prepuce, Ulcer | 4 4 |
Scrotal, Abscess | 4 4 |
Scrotal, Ulcer | 4 4 4 4 4 |
Subcutaneous Tissue, Inflammation, | |
Acute | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Subcutaneous Tissue, Head, Abscess | |
Subcutaneous Tissue, Head, | |
Inflammation, Acute | |
Tail, Inflammation, Acute | |
Tail, Necrosis | 4 |
Thoracic, Alopecia | |
Ventral, Alopecia | 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 2| 5| 6| 4| 4| 5| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 5| 5| 5| 7|
DAY ON TEST | 4| 2| 3| 4| 3| 9| 5| 6| 3| 3| 4| 2| 0| 2| 3| 3| 3| 0| 2| 7| 3| 3| 4| 4| 2|
| 6| 9| 1| 3| 1| 1| 7| 9| 8| 4| 9| 9| 8| 9| 3| 3| 2| 1| 9| 6| 1| 4| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | |
Mineralization | 2 2 2 2 2 2 2 2 2 2 2 3 3 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 2 2 2 2 2 |
Hemorrhage | 1 1 |
Infiltration Cellular, Lymphocyte | 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2|
Mineralization | 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
Interstitium, Inflammation, Acute | 2 1 2 |
Interstitium, Inflammation, Chronic | |
Peribronchiolar, Inflammation, Acute | |
Peribronchiolar, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 2 2 2 2 2 1 2 2 1 2 2 2 3 1 2 |
Mucosa, Inflammation, Acute | |
Nasolacrimal Duct, Hemorrhage | 2 2|
Nasolacrimal Duct, Inflammation, | |
Acute | |
Olfactory Epithelium, Degeneration | 1 1 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2|
Respiratory Epithelium, Degeneration | 2 1 |
Turbinate, Inflammation, Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Erosion | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Inflammation, Acute | 3 3 |
Inflammation, Chronic | |
Cortex, Cyst | X |
Pelvis, Dilatation | 3 2 1 3 2 |
Pelvis, Inflammation, Acute | 3 |
Pelvis, Inflammation, Chronic | |
Pelvis, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 2| 5| 6| 4| 4| 5| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 5| 5| 5| 7|
DAY ON TEST | 4| 2| 3| 4| 3| 9| 5| 6| 3| 3| 4| 2| 0| 2| 3| 3| 3| 0| 2| 7| 3| 3| 4| 4| 2|
| 6| 9| 1| 3| 1| 1| 7| 9| 8| 4| 9| 9| 8| 9| 3| 3| 2| 1| 9| 6| 1| 4| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Casts Protein | 2 1 |
Renal Tubule, Cyst | |
Renal Tubule, Dilatation | 1 2 2 1 |
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Mineralization | 2 |
Renal Tubule, Necrosis | 1 1 |
Renal Tubule, Regeneration | 2 1 2 2 2 1 1 2 1 1 1 1 2|
__________________________________________________________________________|
Ureter | + + + + |
Dilatation | |
Inflammation, Acute | |
__________________________________________________________________________|
Urethra | + + |
Calculus Micro Observation Only | X |
Inflammation, Acute | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Calculus Gross Observation | |
Calculus Micro Observation Only | |
Ectasia | 3 3 3 3 2 |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 1 2 2 2 1 1 2 2 1 2 2 2 2 1 2|
Inflammation, Acute | 4 2 3 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 6| 4| 6| 7| 7| 4| 3| 7| 7| 6| 5| 6| 6| 4| 5| 7| 4| 7| 6| 3| 7| 2| 7| 7|
DAY ON TEST | 7| 3| 4| 4| 3| 3| 3| 7| 3| 3| 1| 2| 1| 0| 9| 2| 3| 4| 3| 3| 3| 3| 9| 2| 1|
| 0| 3| 2| 0| 0| 3| 6| 2| 1| 3| 3| 0| 8| 4| 1| 6| 2| 3| 0| 9| 1| 3| 1| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Infiltration Cellular, Lymphocyte | 2 1 2 2 1 |
Inflammation, Acute | |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + M + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bile Stasis | |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 1 1 1 1 2 2 2 2 2 1 2 |
Infarct | |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 2 |
Necrosis | 2 |
Centrilobular, Fatty Change | |
Periportal, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + |
Artery, Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 1 2 2 2 |
Acinus, Atrophy | |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Glandular | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 1 2 1 2 1 2 2 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 6| 4| 6| 7| 7| 4| 3| 7| 7| 6| 5| 6| 6| 4| 5| 7| 4| 7| 6| 3| 7| 2| 7| 7|
DAY ON TEST | 7| 3| 4| 4| 3| 3| 3| 7| 3| 3| 1| 2| 1| 0| 9| 2| 3| 4| 3| 3| 3| 3| 9| 2| 1|
| 0| 3| 2| 0| 0| 3| 6| 2| 1| 3| 3| 0| 8| 4| 1| 6| 2| 3| 0| 9| 1| 3| 1| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 1|
Inflammation, Acute | |
Inflammation, Chronic Active | 2 |
Mucosa, Dilatation | 2 |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Tooth | + + |
Pulp, Inflammation, Acute | 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 2 2 1 |
Inflammation, Chronic | 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 2 2 2 |
Pigmentation | 2 3 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + M M + M M + M + M + + M + M M M + M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 1 |
Follicle, Cyst | |
Follicle, Dilatation | 2 2|
Follicle, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 4 |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 6| 4| 6| 7| 7| 4| 3| 7| 7| 6| 5| 6| 6| 4| 5| 7| 4| 7| 6| 3| 7| 2| 7| 7|
DAY ON TEST | 7| 3| 4| 4| 3| 3| 3| 7| 3| 3| 1| 2| 1| 0| 9| 2| 3| 4| 3| 3| 3| 3| 9| 2| 1|
| 0| 3| 2| 0| 0| 3| 6| 2| 1| 3| 3| 0| 8| 4| 1| 6| 2| 3| 0| 9| 1| 3| 1| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Penis | + + + + + + + |
Concretion | |
Inflammation, Acute | 4 4 4 4 4 4 3 |
Inflammation | |
__________________________________________________________________________|
Preputial Gland | + M + + + + + + + |
Abscess | 4 4 4 |
Cyst | 4 X |
Inflammation, Acute | 4 4 |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 |
Inflammation, Acute | 4 3 4 4 |
Inflammation, Chronic | 3 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 3 |
Granuloma Sperm | 2 3 |
Hemorrhage | 4 |
Infiltration Cellular, Lymphocyte | |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 3 2 |
Iliac, Hyperplasia, Lymphoid | 2 3 2 2 2 |
Inguinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 2 2|
Mesenteric, Congestion | 2 3 2 2 2 2 3 3 2 2|
Mesenteric, Hemorrhage | |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 |
Mesenteric, Inflammation, Acute | 3 2 |
Renal, Congestion | |
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2|
Inflammation, Acute | 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 6| 4| 6| 7| 7| 4| 3| 7| 7| 6| 5| 6| 6| 4| 5| 7| 4| 7| 6| 3| 7| 2| 7| 7|
DAY ON TEST | 7| 3| 4| 4| 3| 3| 3| 7| 3| 3| 1| 2| 1| 0| 9| 2| 3| 4| 3| 3| 3| 3| 9| 2| 1|
| 0| 3| 2| 0| 0| 3| 6| 2| 1| 3| 3| 0| 8| 4| 1| 6| 2| 3| 0| 9| 1| 3| 1| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 3 3 2 2 3 2 3 2 2 2 2 2 2 2 2 3 1 2 2 2 2 2 2 |
Hyperplasia, Lymphoid | 2 2 3 2 2 2 |
Pigmentation | 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + M + + + M + + + + + + + +|
Cyst | |
Ectopic Parathyroid Gland | X |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M + M M M M M M + + M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 |
Inflammation, Acute | 1 |
Inflammation, Chronic | 3 |
Ulcer | 4 4 4 |
Head, Inflammation, Acute | 2 |
Head, Inflammation, Chronic | |
Inguinal, Abscess | 4 |
Inguinal, Ulcer | |
Prepuce, Abscess | 4 |
Prepuce, Ulcer | 4 4 4 4 4 4 |
Scrotal, Abscess | 4 4 4 |
Scrotal, Ulcer | 4 4 4 |
Subcutaneous Tissue, Inflammation, | |
Acute | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 2 |
Subcutaneous Tissue, Head, Abscess | 3 |
Subcutaneous Tissue, Head, | |
Inflammation, Acute | 2 |
Tail, Inflammation, Acute | |
Tail, Necrosis | |
Thoracic, Alopecia | 3 |
Ventral, Alopecia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 6| 4| 6| 7| 7| 4| 3| 7| 7| 6| 5| 6| 6| 4| 5| 7| 4| 7| 6| 3| 7| 2| 7| 7|
DAY ON TEST | 7| 3| 4| 4| 3| 3| 3| 7| 3| 3| 1| 2| 1| 0| 9| 2| 3| 4| 3| 3| 3| 3| 9| 2| 1|
| 0| 3| 2| 0| 0| 3| 6| 2| 1| 3| 3| 0| 8| 4| 1| 6| 2| 3| 0| 9| 1| 3| 1| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 2 |
Mineralization | 2 2 2 2 2 2 2 2 2 2 2 2 3 2 3 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Hemorrhage | 2 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 |
Mineralization | |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 |
Interstitium, Inflammation, Acute | |
Interstitium, Inflammation, Chronic | 2 |
Peribronchiolar, Inflammation, Acute | 2 |
Peribronchiolar, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + M + + + +|
Lumen, Hemorrhage | 2 2 2 3 2 2 2 2 1 2 1 2 2 2 2 |
Mucosa, Inflammation, Acute | |
Nasolacrimal Duct, Hemorrhage | |
Nasolacrimal Duct, Inflammation, | |
Acute | 2|
Olfactory Epithelium, Degeneration | 2 2 2 2 2 1 2 1 2 1 2 2 2 1 2 1 2|
Respiratory Epithelium, Degeneration | 2 1 1 1 1 |
Turbinate, Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Erosion | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 3 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2|
Inflammation, Acute | 3 |
Inflammation, Chronic | 3 |
Cortex, Cyst | X |
Pelvis, Dilatation | 3 3 3 2 3 2 |
Pelvis, Inflammation, Acute | 3 2 2 3 |
Pelvis, Inflammation, Chronic | |
Pelvis, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 4| 6| 4| 6| 7| 7| 4| 3| 7| 7| 6| 5| 6| 6| 4| 5| 7| 4| 7| 6| 3| 7| 2| 7| 7|
DAY ON TEST | 7| 3| 4| 4| 3| 3| 3| 7| 3| 3| 1| 2| 1| 0| 9| 2| 3| 4| 3| 3| 3| 3| 9| 2| 1|
| 0| 3| 2| 0| 0| 3| 6| 2| 1| 3| 3| 0| 8| 4| 1| 6| 2| 3| 0| 9| 1| 3| 1| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Casts Protein | 2 |
Renal Tubule, Cyst | 2 2 |
Renal Tubule, Dilatation | 2 1 1 1 1 1 2 1|
Renal Tubule, Hyperplasia | |
Renal Tubule, Mineralization | 2 |
Renal Tubule, Necrosis | 1 2 2 |
Renal Tubule, Regeneration | 2 2 1 2 2 2 2 1 2 2 2 1 2 1 2 2 2 2|
__________________________________________________________________________|
Ureter | + + + |
Dilatation | 1 2 |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Urethra | + + + |
Calculus Micro Observation Only | X X |
Inflammation, Acute | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Calculus Gross Observation | |
Calculus Micro Observation Only | X |
Ectasia | 3 3 3 2 3 1 3 3 3 2 3 2 |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 1 1 2 2 2 2 2 2 2 2 1|
Inflammation, Acute | 4 2 4 4 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 4 2 |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 3| 5| 5| 5| 6| 7| 5| 2| 7| | |
DAY ON TEST | 2| 8| 7| 6| 9| 2| 1| 2| 9| 1| | |
| 9| 8| 9| 3| 0| 9| 3| 8| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 59 |
Cyst | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 6 1.7|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Ulcer | 3 | 4 3.5|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Bile Stasis | | 1 2.0|
Focal Cellular Change | | 1 |
Hematopoietic Cell Proliferation | 1 1 2 | 21 1.7|
Infarct | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 2 1.0|
Inflammation, Acute | 1 | 3 1.7|
Inflammation, Chronic | 2 | 3 2.0|
Necrosis | 1 | 5 2.4|
Centrilobular, Fatty Change | | 1 1.0|
Periportal, Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Artery, Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 11 1.7|
Acinus, Atrophy | | 1 3.0|
Acinus, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Hemorrhage | | 1 4.0|
Hyperplasia, Glandular | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 2 1 2 2 1 | 30 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 3| 5| 5| 5| 6| 7| 5| 2| 7| | |
DAY ON TEST | 2| 8| 7| 6| 9| 2| 1| 2| 9| 1| | |
| 9| 8| 9| 3| 0| 9| 3| 8| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Acute | 1 | 4 1.8|
Inflammation, Chronic Active | | 2 2.5|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | 2 3 | 4 2.3|
Infiltration Cellular, Lymphocyte | 2 1 2 2 | 14 1.9|
Inflammation, Acute | | 2 2.5|
Inflammation, Chronic Active | | 1 2.0|
Mucosa, Dilatation | | 2 2.0|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Pulp, Inflammation, Acute | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 59 |
Aorta, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 9 1.2|
Inflammation, Chronic | | 5 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
Capsule, Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 | 59 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Hypertrophy | | 4 2.0|
Pigmentation | | 8 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M M | 30 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | 1 1 | 8 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 3| 5| 5| 5| 6| 7| 5| 2| 7| | |
DAY ON TEST | 2| 8| 7| 6| 9| 2| 1| 2| 9| 1| | |
| 9| 8| 9| 3| 0| 9| 3| 8| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicle, Cyst | 2 2 | 2 2.0|
Follicle, Dilatation | | 3 2.0|
Follicle, Hyperplasia | | 4 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Granuloma Sperm | 3 4 | 3 3.7|
Infiltration Cellular, Lymphocyte | 2 2 2 | 9 1.9|
__________________________________________________________________________|____________|
Penis | + + + + + | 17 |
Concretion | 3 | 1 3.0|
Inflammation, Acute | 4 4 4 4 | 16 3.9|
Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 12 |
Abscess | | 4 4.0|
Cyst | | 3 3.5|
Inflammation, Acute | | 2 4.0|
Inflammation, Chronic | 3 | 3 3.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 8 2.0|
Inflammation, Acute | 3 3 2 3 | 14 3.2|
Inflammation, Chronic | | 2 3.0|
Inflammation, Chronic Active | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 4 |
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Atrophy | 2 3 | 9 2.8|
Granuloma Sperm | | 2 2.5|
Hemorrhage | | 1 4.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Interstitial Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 | 51 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 3| 5| 5| 5| 6| 7| 5| 2| 7| | |
DAY ON TEST | 2| 8| 7| 6| 9| 2| 1| 2| 9| 1| | |
| 9| 8| 9| 3| 0| 9| 3| 8| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Congestion | 3 | 2 3.0|
Hyperplasia, Lymphoid | 2 | 4 2.3|
Iliac, Hyperplasia, Lymphoid | 3 2 3 3 | 10 2.4|
Inguinal, Hyperplasia, Lymphoid | 2 | 2 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 4 2.0|
Mesenteric, Congestion | 2 2 2 4 | 20 2.4|
Mesenteric, Hemorrhage | | 1 3.0|
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 2 3 | 32 2.2|
Mesenteric, Inflammation, Acute | | 4 2.8|
Renal, Congestion | 2 | 1 2.0|
Renal, Hyperplasia, Lymphoid | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + | 53 |
Hyperplasia, Lymphoid | 2 2 2 2 2 1 2 | 38 2.0|
Inflammation, Acute | | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Angiectasis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 2 3 3 2 2 2 2 3 | 54 2.2|
Hyperplasia, Lymphoid | | 10 2.2|
Pigmentation | 1 | 4 1.5|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + | 53 |
Cyst | | 3 2.0|
Ectopic Parathyroid Gland | | 1 |
Hyperplasia, Lymphoid | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 6 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Alopecia | 2 2 | 4 2.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | 2 | 2 2.5|
Ulcer | | 3 4.0|
Head, Inflammation, Acute | 2 | 2 2.0|
Head, Inflammation, Chronic | 3 2 | 3 2.3|
Inguinal, Abscess | | 1 4.0|
Inguinal, Ulcer | 4 | 1 4.0|
Prepuce, Abscess | | 2 4.0|
Prepuce, Ulcer | 4 | 9 4.0|
Scrotal, Abscess | | 5 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 3| 5| 5| 5| 6| 7| 5| 2| 7| | |
DAY ON TEST | 2| 8| 7| 6| 9| 2| 1| 2| 9| 1| | |
| 9| 8| 9| 3| 0| 9| 3| 8| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Scrotal, Ulcer | 4 4 4 4 4 4 4 4 | 16 4.0|
Subcutaneous Tissue, Inflammation, | | |
Acute | | 2 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 2.0|
Subcutaneous Tissue, Head, Abscess | 3 | 2 3.0|
Subcutaneous Tissue, Head, | | |
Inflammation, Acute | | 1 2.0|
Tail, Inflammation, Acute | 1 | 1 1.0|
Tail, Necrosis | | 1 4.0|
Thoracic, Alopecia | | 1 3.0|
Ventral, Alopecia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Femur, Hyperostosis | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Hemorrhage | | 2 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Mineralization | 2 2 1 2 2 2 2 | 40 2.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 2 | 11 2.1|
Hemorrhage | 2 2 | 6 1.7|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 1 | 50 1.9|
Mineralization | 2 | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 3 2.3|
Interstitium, Inflammation, Acute | 2 1 | 5 1.6|
Interstitium, Inflammation, Chronic | | 1 2.0|
Peribronchiolar, Inflammation, Acute | | 1 2.0|
Peribronchiolar, Inflammation, | | |
Chronic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Lumen, Hemorrhage | 2 2 1 1 2 1 | 36 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 3| 5| 5| 5| 6| 7| 5| 2| 7| | |
DAY ON TEST | 2| 8| 7| 6| 9| 2| 1| 2| 9| 1| | |
| 9| 8| 9| 3| 0| 9| 3| 8| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mucosa, Inflammation, Acute | 2 | 1 2.0|
Nasolacrimal Duct, Hemorrhage | | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
Olfactory Epithelium, Degeneration | 2 2 2 1 2 2 2 | 41 1.8|
Respiratory Epithelium, Degeneration | | 7 1.3|
Turbinate, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Mucosa, Erosion | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Cyst | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 2 2 2 2 | 53 2.0|
Inflammation, Acute | 3 | 4 3.0|
Inflammation, Chronic | | 1 3.0|
Cortex, Cyst | | 2 |
Pelvis, Dilatation | 2 3 3 | 14 2.5|
Pelvis, Inflammation, Acute | 2 2 | 7 2.4|
Pelvis, Inflammation, Chronic | 2 | 1 2.0|
Pelvis, Inflammation, Chronic Active | 2 | 1 2.0|
Renal Tubule, Casts Protein | 2 | 4 1.8|
Renal Tubule, Cyst | | 2 2.0|
Renal Tubule, Dilatation | 2 | 13 1.4|
Renal Tubule, Hyperplasia | | 1 2.0|
Renal Tubule, Mineralization | | 2 2.0|
Renal Tubule, Necrosis | 2 | 6 1.5|
Renal Tubule, Regeneration | 1 2 2 2 1 | 36 1.6|
__________________________________________________________________________|____________|
Ureter | + | 8 |
Dilatation | 2 | 3 1.7|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Urethra | | 5 |
Calculus Micro Observation Only | | 3 |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 3| 5| 5| 5| 6| 7| 5| 2| 7| | |
DAY ON TEST | 2| 8| 7| 6| 9| 2| 1| 2| 9| 1| | |
| 9| 8| 9| 3| 0| 9| 3| 8| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Angiectasis | | 2 2.5|
Calculus Gross Observation | X | 1 |
Calculus Micro Observation Only | | 1 |
Ectasia | 2 3 | 19 2.6|
Hemorrhage | 3 | 1 3.0|
Infiltration Cellular, Lymphocyte | 1 | 27 1.7|
Inflammation, Acute | 4 3 4 | 10 3.4|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | 2 4 4 3 | 6 3.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 5| 3| 6| 2| 3| 6| 6| 4| 5| 5| 2| 7| 6| 4| 2| 4| 3| 4| 4| 4| 5| 5| 3| 6|
DAY ON TEST | 3| 0| 7| 8| 2| 7| 7| 1| 8| 6| 7| 7| 3| 3| 2| 7| 7| 3| 0| 5| 1| 0| 7| 2| 3|
| 3| 8| 9| 9| 9| 4| 4| 9| 5| 3| 7| 8| 0| 9| 5| 7| 3| 1| 5| 2| 8| 0| 6| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + M + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Anorectal Junction, Erosion | |
Anus, Erosion | |
Anus, Inflammation, Acute | 3 |
Anus, Inflammation, Chronic Active | 3|
Anus, Ulcer | 4 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 4 |
Inflammation, Chronic | 3 |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hematopoietic Cell Proliferation | 1 1 2 2 2 1 |
Infarct | 4|
Infiltration Cellular, Lymphocyte | 1 1 2 |
Inflammation, Acute | 2 2|
Inflammation, Chronic | 2 |
Necrosis | 2|
__________________________________________________________________________|
Mesentery | |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 |
Inflammation, Chronic | |
Acinus, Atrophy | 1 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 2 2 2 1 2 1 1 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 5| 3| 6| 2| 3| 6| 6| 4| 5| 5| 2| 7| 6| 4| 2| 4| 3| 4| 4| 4| 5| 5| 3| 6|
DAY ON TEST | 3| 0| 7| 8| 2| 7| 7| 1| 8| 6| 7| 7| 3| 3| 2| 7| 7| 3| 0| 5| 1| 0| 7| 2| 3|
| 3| 8| 9| 9| 9| 4| 4| 9| 5| 3| 7| 8| 0| 9| 5| 7| 3| 1| 5| 2| 8| 0| 6| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperplasia, Squamous | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2|
Infiltration Cellular, Lymphocyte | 2 2 2 1 2 2 2 |
Mucosa, Dilatation | |
Submucosa, Edema | |
__________________________________________________________________________|
Tooth | + +|
Pulp, Inflammation, Acute | 2 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Infiltration Cellular, Lymphocyte | 2 1 2 |
Inflammation, Acute | 2|
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | |
Mineralization | 2 |
Ventricle Right, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 |
Capsule, Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy | |
Pigmentation | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Necrosis | |
__________________________________________________________________________|
Parathyroid Gland | M + M M + + M + + M + M M + M M + + + + + M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Follicle, Cyst | 2 |
Follicle, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 5| 3| 6| 2| 3| 6| 6| 4| 5| 5| 2| 7| 6| 4| 2| 4| 3| 4| 4| 4| 5| 5| 3| 6|
DAY ON TEST | 3| 0| 7| 8| 2| 7| 7| 1| 8| 6| 7| 7| 3| 3| 2| 7| 7| 3| 0| 5| 1| 0| 7| 2| 3|
| 3| 8| 9| 9| 9| 4| 4| 9| 5| 3| 7| 8| 0| 9| 5| 7| 3| 1| 5| 2| 8| 0| 6| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 2 |
Inflammation, Acute | 4 3 |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 3|
__________________________________________________________________________|
Penis | + + + + + + + + +|
Abscess | |
Inflammation, Acute | 4 4 4 4 4 4 4|
Necrosis | 4 4 4|
__________________________________________________________________________|
Preputial Gland | + + + |
Abscess | 4 4 |
Cyst | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + M + +|
Infiltration Cellular, Lymphocyte | 2 2 2 |
Inflammation, Acute | 3 3 1 3 |
Inflammation, Chronic Active | 3 4 3|
__________________________________________________________________________|
Seminal Vesicle | + |
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Inflammation, Acute | 3 |
Interstitial Cell, Hyperplasia | 2 |
Tunic, Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 1 |
Inflammation, Acute | |
Iliac, Hyperplasia, Lymphoid | 2 2 3 3 |
Iliac, Inflammation, Acute | |
Inguinal, Hyperplasia, Lymphoid | 3 4 3 |
Lumbar, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 2 |
Mesenteric, Congestion | 4 2 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 1 2 2 2 2 2 2 2 2 3 2 2|
Mesenteric, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 5| 3| 6| 2| 3| 6| 6| 4| 5| 5| 2| 7| 6| 4| 2| 4| 3| 4| 4| 4| 5| 5| 3| 6|
DAY ON TEST | 3| 0| 7| 8| 2| 7| 7| 1| 8| 6| 7| 7| 3| 3| 2| 7| 7| 3| 0| 5| 1| 0| 7| 2| 3|
| 3| 8| 9| 9| 9| 4| 4| 9| 5| 3| 7| 8| 0| 9| 5| 7| 3| 1| 5| 2| 8| 0| 6| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + M + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 2 2 1 2 2 2 2 2 2 1 2 2 4 2 2|
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 2 4 2 2 2 3 2 3 2 3 3 3 1 1 2 2 2 3 2 2 3 1 3 2 3|
Hyperplasia, Lymphoid | |
Pigmentation | 1 2 2 1 |
Capsule, Inflammation, Chronic Active| 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M + M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 |
Inflammation, Chronic | |
Ulcer | 4 4 |
Foot, Ulcer | 4 |
Head, Inflammation, Chronic | |
Inguinal, Inflammation, Acute | 2 |
Inguinal, Ulcer | 4 |
Neck, Abscess | 4 |
Prepuce, Ulcer | 4 4 4 4 |
Scrotal, Abscess | |
Scrotal, Inflammation, Chronic Active| 3 |
Scrotal, Ulcer | 4 4 4 4 4 4 4 4 4 4|
Subcutaneous Tissue, Head, Abscess | |
Tail, Inflammation, Chronic | 2 |
Tail, Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + +|
Abscess | 4 |
Head, Abscess | 3 2 3 3|
Head, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 5| 3| 6| 2| 3| 6| 6| 4| 5| 5| 2| 7| 6| 4| 2| 4| 3| 4| 4| 4| 5| 5| 3| 6|
DAY ON TEST | 3| 0| 7| 8| 2| 7| 7| 1| 8| 6| 7| 7| 3| 3| 2| 7| 7| 3| 0| 5| 1| 0| 7| 2| 3|
| 3| 8| 9| 9| 9| 4| 4| 9| 5| 3| 7| 8| 0| 9| 5| 7| 3| 1| 5| 2| 8| 0| 6| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage | 2 |
Mineralization | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 2 2 |
Granuloma | 3 |
Hemorrhage | 2 2 2 2 2 2 3 1 |
Infiltration Cellular, Lymphocyte | 1 2 2 2 2 1 2 2 2 2 2 1 2 2 2 2 2 1 2 2 2 2 1 1|
Inflammation, Acute | 2|
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Arteriole, Inflammation, Acute | |
Artery, Inflammation, Acute | |
Interstitium, Inflammation, Acute | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 2 1 2 2 2 2 2 2 2 2 2 2|
Mucosa, Inflammation, Acute | |
Nasolacrimal Duct, Inflammation, | |
Acute | 1 2 |
Olfactory Epithelium, Degeneration | 2 1 2 2 2 2 1 2 2 2 2|
Respiratory Epithelium, Degeneration | 1 2 2|
Septum, Inflammation, Acute | |
Turbinate, Congestion | |
Vomeronasal Organ, Inflammation, | |
Acute | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Hemorrhage | 2 |
Infiltration Cellular, Lymphocyte | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Inflammation, Acute | 3 4 2|
Inflammation, Chronic Active | 3 |
Metaplasia, Osseous | 2 |
Pelvis, Dilatation | 2 2 2 2 3 |
Pelvis, Inflammation, Acute | 1 2 |
Renal Tubule, Casts Protein | 2 |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 5| 3| 6| 2| 3| 6| 6| 4| 5| 5| 2| 7| 6| 4| 2| 4| 3| 4| 4| 4| 5| 5| 3| 6|
DAY ON TEST | 3| 0| 7| 8| 2| 7| 7| 1| 8| 6| 7| 7| 3| 3| 2| 7| 7| 3| 0| 5| 1| 0| 7| 2| 3|
| 3| 8| 9| 9| 9| 4| 4| 9| 5| 3| 7| 8| 0| 9| 5| 7| 3| 1| 5| 2| 8| 0| 6| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Cyst | 2|
Renal Tubule, Dilatation | 2 2 1 2 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Mineralization | |
Renal Tubule, Necrosis | 2 2|
Renal Tubule, Regeneration | 1 2 1 1 2 1 1 2 2|
__________________________________________________________________________|
Ureter | + |
Dilatation | 2 |
__________________________________________________________________________|
Urethra | + |
Inflammation, Acute | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 3 2 1 3 2 3 2 2|
Infiltration Cellular, Lymphocyte | 1 2 1 2 2 2 2 2 2 2 2 2 2 1 |
Inflammation, Acute | 4 2 2 4 2 4|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 4| 4| 4| 7| 3| 4| 5| 7| 7| 5| 3| 7| 4| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 2| 1| 3| 2| 5| 3| 5| 3| 4| 3| 1| 3| 6| 3| 3| 5| 9| 3| 4| 5| 2| 3| 3| 3|
| 3| 4| 6| 1| 9| 1| 2| 0| 0| 3| 1| 9| 0| 3| 1| 1| 5| 0| 2| 8| 4| 9| 0| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + M + M + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 2 2 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Anorectal Junction, Erosion | 2 |
Anus, Erosion | 2 2 |
Anus, Inflammation, Acute | |
Anus, Inflammation, Chronic Active | |
Anus, Ulcer | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | |
Ulcer | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hematopoietic Cell Proliferation | 1 2 2 2 2 1 1|
Infarct | |
Infiltration Cellular, Lymphocyte | 1 2 2 2 1 1 |
Inflammation, Acute | |
Inflammation, Chronic | |
Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + |
Artery, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Infiltration Cellular, Lymphocyte | 2 1 1 2 1 1 1|
Inflammation, Chronic | |
Acinus, Atrophy | |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 1 2 2 2 2 2 1 2 1 2 2 2 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 4| 4| 4| 7| 3| 4| 5| 7| 7| 5| 3| 7| 4| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 2| 1| 3| 2| 5| 3| 5| 3| 4| 3| 1| 3| 6| 3| 3| 5| 9| 3| 4| 5| 2| 3| 3| 3|
| 3| 4| 6| 1| 9| 1| 2| 0| 0| 3| 1| 9| 0| 3| 1| 1| 5| 0| 2| 8| 4| 9| 0| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperplasia, Squamous | |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 2 2 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 1 2 2 2 2 |
Mucosa, Dilatation | 2 2 1 1 2|
Submucosa, Edema | 3 |
__________________________________________________________________________|
Tooth | |
Pulp, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Infiltration Cellular, Lymphocyte | 2 1 1 1 |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Mineralization | |
Ventricle Right, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | |
Capsule, Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Hypertrophy | 2 2 |
Pigmentation | 2 2 2 2 2 1 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Necrosis | |
__________________________________________________________________________|
Parathyroid Gland | M M M M M M M + + M M M + M M M M + M + M M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 |
Follicle, Cyst | |
Follicle, Hyperplasia | 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 4| 4| 4| 7| 3| 4| 5| 7| 7| 5| 3| 7| 4| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 2| 1| 3| 2| 5| 3| 5| 3| 4| 3| 1| 3| 6| 3| 3| 5| 9| 3| 4| 5| 2| 3| 3| 3|
| 3| 4| 6| 1| 9| 1| 2| 0| 0| 3| 1| 9| 0| 3| 1| 1| 5| 0| 2| 8| 4| 9| 0| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 2 |
Inflammation, Acute | |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Penis | + + + + + + + |
Abscess | 4 |
Inflammation, Acute | 4 4 4 4 4 |
Necrosis | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Abscess | 4 |
Cyst | X X |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 1 2 2 2 2 |
Inflammation, Acute | 3 3 4 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + |
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Inflammation, Acute | |
Interstitial Cell, Hyperplasia | 1 |
Tunic, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Acute | 2 |
Iliac, Hyperplasia, Lymphoid | 2 |
Iliac, Inflammation, Acute | |
Inguinal, Hyperplasia, Lymphoid | |
Lumbar, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | 2 2 2 |
Mesenteric, Congestion | 3 3 2 3 3 3 2 3 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 3 2 2 2 2 2 2 1 2 2 2 2 2 2|
Mesenteric, Inflammation, Acute | 3 2 |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 4| 4| 4| 7| 3| 4| 5| 7| 7| 5| 3| 7| 4| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 2| 1| 3| 2| 5| 3| 5| 3| 4| 3| 1| 3| 6| 3| 3| 5| 9| 3| 4| 5| 2| 3| 3| 3|
| 3| 4| 6| 1| 9| 1| 2| 0| 0| 3| 1| 9| 0| 3| 1| 1| 5| 0| 2| 8| 4| 9| 0| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + M + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3|
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 2 2 2 3 3 2 3 3 2 2 2 2 1 2 2 2|
Hyperplasia, Lymphoid | 1 2 2 3 3 2|
Pigmentation | 2 1 2 1 1 1 |
Capsule, Inflammation, Chronic Active| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 X |
Hyperplasia, Lymphoid | 2 4 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M + M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 |
Inflammation, Chronic | |
Ulcer | |
Foot, Ulcer | |
Head, Inflammation, Chronic | 2 |
Inguinal, Inflammation, Acute | |
Inguinal, Ulcer | |
Neck, Abscess | |
Prepuce, Ulcer | 4 4 4 4 |
Scrotal, Abscess | 4 |
Scrotal, Inflammation, Chronic Active| |
Scrotal, Ulcer | 4 4 |
Subcutaneous Tissue, Head, Abscess | 3 |
Tail, Inflammation, Chronic | |
Tail, Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Abscess | |
Head, Abscess | |
Head, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 4| 4| 4| 7| 3| 4| 5| 7| 7| 5| 3| 7| 4| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 2| 1| 3| 2| 5| 3| 5| 3| 4| 3| 1| 3| 6| 3| 3| 5| 9| 3| 4| 5| 2| 3| 3| 3|
| 3| 4| 6| 1| 9| 1| 2| 0| 0| 3| 1| 9| 0| 3| 1| 1| 5| 0| 2| 8| 4| 9| 0| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage | 2 |
Mineralization | 2 1 2 2 1 2 2 2 2 1 2 2 3 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Granuloma | |
Hemorrhage | 2 1 1 2 2 2 |
Infiltration Cellular, Lymphocyte | 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2|
Inflammation, Acute | |
Alveolar Epithelium, Hyperplasia | 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Arteriole, Inflammation, Acute | 4 |
Artery, Inflammation, Acute | 4 |
Interstitium, Inflammation, Acute | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 2 2 2 2 2 2 2 2 3 1 2 1 2 2 2 2 1 1 2 2|
Mucosa, Inflammation, Acute | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Olfactory Epithelium, Degeneration | 2 1 1 2 1 2 1 2 2 2 2 2 |
Respiratory Epithelium, Degeneration | 2 1 2 1|
Septum, Inflammation, Acute | 2 |
Turbinate, Congestion | 3 |
Vomeronasal Organ, Inflammation, | |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Inflammation, Acute | |
Inflammation, Chronic Active | |
Metaplasia, Osseous | |
Pelvis, Dilatation | 2 2 2 2 |
Pelvis, Inflammation, Acute | 2 |
Renal Tubule, Casts Protein | 2 1|
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 4| 4| 4| 7| 3| 4| 5| 7| 7| 5| 3| 7| 4| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 2| 1| 3| 2| 5| 3| 5| 3| 4| 3| 1| 3| 6| 3| 3| 5| 9| 3| 4| 5| 2| 3| 3| 3|
| 3| 4| 6| 1| 9| 1| 2| 0| 0| 3| 1| 9| 0| 3| 1| 1| 5| 0| 2| 8| 4| 9| 0| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Cyst | |
Renal Tubule, Dilatation | 2 1 1 2 2 2 1 2|
Renal Tubule, Hyperplasia | |
Renal Tubule, Mineralization | 2 |
Renal Tubule, Necrosis | 1 1 1 2 1|
Renal Tubule, Regeneration | 2 2 2 2 2 2 1 2 2 2 2 1 1 2 2|
__________________________________________________________________________|
Ureter | + |
Dilatation | 2 |
__________________________________________________________________________|
Urethra | |
Inflammation, Acute | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 2 3 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 |
Inflammation, Acute | 4 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 4| 5| 7| 7| 7| 5| 3| | |
DAY ON TEST | 3| 2| 6| 7| 1| 2| 3| 2| 6| 0| | |
| 9| 5| 3| 0| 8| 9| 0| 9| 9| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 57 |
Infiltration Cellular, Lymphocyte | 1 2 | 8 1.6|
Inflammation, Acute | 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
Anorectal Junction, Erosion | | 1 2.0|
Anus, Erosion | | 2 2.0|
Anus, Inflammation, Acute | | 1 3.0|
Anus, Inflammation, Chronic Active | | 1 3.0|
Anus, Ulcer | | 2 4.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Cyst | | 1 |
Hematopoietic Cell Proliferation | 1 2 1 2 | 17 1.5|
Infarct | | 1 4.0|
Infiltration Cellular, Lymphocyte | 2 | 10 1.5|
Inflammation, Acute | | 2 2.0|
Inflammation, Chronic | | 1 2.0|
Necrosis | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Artery, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Fibrosis | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 1 2 2 2 2 | 18 1.4|
Inflammation, Chronic | 2 | 1 2.0|
Acinus, Atrophy | | 1 1.0|
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 4| 5| 7| 7| 7| 5| 3| | |
DAY ON TEST | 3| 2| 6| 7| 1| 2| 3| 2| 6| 0| | |
| 9| 5| 3| 0| 8| 9| 0| 9| 9| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | 2 2 1 2 2 2 2 2 | 34 1.8|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | | 1 2.0|
Hyperplasia, Squamous | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | | 6 1.8|
Infiltration Cellular, Lymphocyte | | 17 1.9|
Mucosa, Dilatation | | 5 1.6|
Submucosa, Edema | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Pulp, Inflammation, Acute | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Atrophy | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 2 | 9 1.6|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Mineralization | | 1 2.0|
Ventricle Right, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + M + + + + + | 59 |
Capsule, Hyperplasia | | 1 2.0|
Capsule, Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 | 53 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + M + + + + + | 59 |
Hyperplasia | 2 | 2 2.0|
Hypertrophy | 2 | 3 2.0|
Pigmentation | 2 | 10 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + M + + + + + | 58 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 4| 5| 7| 7| 7| 5| 3| | |
DAY ON TEST | 3| 2| 6| 7| 1| 2| 3| 2| 6| 0| | |
| 9| 5| 3| 0| 8| 9| 0| 9| 9| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M M M M M + | 25 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 2 1.5|
Follicle, Cyst | | 1 2.0|
Follicle, Hyperplasia | | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | 2 2 | 8 1.8|
Inflammation, Acute | | 2 3.5|
Inflammation, Chronic | | 2 3.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Penis | + | 17 |
Abscess | | 1 4.0|
Inflammation, Acute | 4 | 13 4.0|
Necrosis | | 4 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 10 |
Abscess | | 3 4.0|
Cyst | | 2 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | | 2 3.0|
Inflammation, Chronic Active | 2 | 3 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Infiltration Cellular, Lymphocyte | 2 2 2 | 16 1.9|
Inflammation, Acute | 3 2 | 9 2.8|
Inflammation, Chronic Active | | 3 3.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 4 |
Dilatation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Atrophy | 3 | 3 2.7|
Inflammation, Acute | | 1 3.0|
Interstitial Cell, Hyperplasia | | 2 1.5|
Tunic, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 4| 5| 7| 7| 7| 5| 3| | |
DAY ON TEST | 3| 2| 6| 7| 1| 2| 3| 2| 6| 0| | |
| 9| 5| 3| 0| 8| 9| 0| 9| 9| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Fibrosis | | 1 1.0|
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 | 56 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + A + + + + + | 59 |
Congestion | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 2 1.5|
Inflammation, Acute | | 1 2.0|
Iliac, Hyperplasia, Lymphoid | | 5 2.4|
Iliac, Inflammation, Acute | 3 | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | | 3 3.3|
Lumbar, Hyperplasia, Lymphoid | 2 | 2 2.5|
Mediastinal, Hyperplasia, Lymphoid | 2 | 6 2.0|
Mesenteric, Congestion | 3 3 | 12 2.8|
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 2 | 35 2.0|
Mesenteric, Inflammation, Acute | 3 | 3 2.7|
Renal, Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + A + + + + + | 54 |
Congestion | | 1 3.0|
Hyperplasia, Lymphoid | 2 2 3 2 2 2 | 38 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Angiectasis | | 2 2.5|
Hematopoietic Cell Proliferation | 2 3 3 2 3 2 2 2 | 56 2.3|
Hyperplasia, Lymphoid | | 6 2.2|
Pigmentation | 1 | 11 1.4|
Capsule, Inflammation, Chronic Active| | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + | 58 |
Cyst | | 2 2.0|
Hyperplasia, Lymphoid | 2 | 4 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + M M M M M M | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Alopecia | 2 | 3 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Ulcer | | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 4| 5| 7| 7| 7| 5| 3| | |
DAY ON TEST | 3| 2| 6| 7| 1| 2| 3| 2| 6| 0| | |
| 9| 5| 3| 0| 8| 9| 0| 9| 9| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Foot, Ulcer | 4 | 2 4.0|
Head, Inflammation, Chronic | | 1 2.0|
Inguinal, Inflammation, Acute | | 1 2.0|
Inguinal, Ulcer | 4 | 2 4.0|
Neck, Abscess | | 1 4.0|
Prepuce, Ulcer | | 8 4.0|
Scrotal, Abscess | | 1 4.0|
Scrotal, Inflammation, Chronic Active| | 1 3.0|
Scrotal, Ulcer | 4 4 4 4 | 16 4.0|
Subcutaneous Tissue, Head, Abscess | | 1 3.0|
Tail, Inflammation, Chronic | | 1 2.0|
Tail, Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 6 |
Abscess | | 1 4.0|
Head, Abscess | | 4 2.8|
Head, Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 1 |
Hemorrhage | | 2 2.0|
Mineralization | 2 2 2 2 2 3 2 | 41 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 5 2.0|
Granuloma | 2 | 2 2.5|
Hemorrhage | 1 1 | 16 1.8|
Infiltration Cellular, Lymphocyte | 2 2 1 2 2 2 2 2 2 1 | 55 1.8|
Inflammation, Acute | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 2 2.0|
Arteriole, Inflammation, Acute | | 1 4.0|
Artery, Inflammation, Acute | | 1 4.0|
Interstitium, Inflammation, Acute | | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 4| 5| 7| 7| 7| 5| 3| | |
DAY ON TEST | 3| 2| 6| 7| 1| 2| 3| 2| 6| 0| | |
| 9| 5| 3| 0| 8| 9| 0| 9| 9| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Lumen, Hemorrhage | 2 2 2 2 2 2 2 1 | 40 1.9|
Mucosa, Inflammation, Acute | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | 1 2 | 5 1.6|
Olfactory Epithelium, Degeneration | 2 1 1 2 | 27 1.7|
Respiratory Epithelium, Degeneration | 1 | 8 1.5|
Septum, Inflammation, Acute | | 1 2.0|
Turbinate, Congestion | | 1 3.0|
Vomeronasal Organ, Inflammation, | | |
Acute | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Abscess | | 1 4.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 2 2 2 3 2 2 2 1 | 52 2.0|
Inflammation, Acute | | 3 3.0|
Inflammation, Chronic Active | | 1 3.0|
Metaplasia, Osseous | | 1 2.0|
Pelvis, Dilatation | | 9 2.1|
Pelvis, Inflammation, Acute | 2 1 | 5 1.6|
Renal Tubule, Casts Protein | 4 | 4 2.3|
Renal Tubule, Cyst | | 1 2.0|
Renal Tubule, Dilatation | 1 4 2 | 15 1.8|
Renal Tubule, Hyperplasia | 2 | 1 2.0|
Renal Tubule, Mineralization | | 1 2.0|
Renal Tubule, Necrosis | 4 2 | 9 1.8|
Renal Tubule, Regeneration | 1 3 3 2 2 | 29 1.8|
__________________________________________________________________________|____________|
Ureter | + | 3 |
Dilatation | 1 | 3 1.7|
__________________________________________________________________________|____________|
Urethra | | 1 |
Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 4| 5| 7| 7| 7| 5| 3| | |
DAY ON TEST | 3| 2| 6| 7| 1| 2| 3| 2| 6| 0| | |
| 9| 5| 3| 0| 8| 9| 0| 9| 9| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Ectasia | 2 3 | 15 2.3|
Infiltration Cellular, Lymphocyte | 1 2 2 2 2 2 2 | 36 1.8|
Inflammation, Acute | | 7 3.1|
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 2| 3| 7| 3| 7| 3| 6| 6| 7| 5| 7| 3| 7| 4| 7| 4| 4| 2| 4| 5| 5| 7| 0| 7| 6|
DAY ON TEST | 9| 6| 0| 6| 3| 3| 9| 6| 3| 8| 0| 6| 3| 2| 2| 2| 6| 9| 4| 7| 4| 3| 3| 2| 3|
| 1| 2| 3| 2| 0| 5| 1| 0| 0| 7| 2| 6| 1| 3| 9| 5| 2| 7| 3| 0| 7| 2| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Anorectal Junction, Inflammation, | |
Acute | 2 |
Anus, Erosion | 4 |
Anus, Ulcer | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Anorectal Junction, Ulcer | 4 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Cyst | 2 |
Hematopoietic Cell Proliferation | 2 1 2 1 2 2|
Hyperplasia | 3 |
Hypertrophy | 2 |
Infarct | |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Acute | 1|
Necrosis | 3 1 2 |
Bile Duct, Hyperplasia | 2 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X|
Infiltration Cellular, Lymphocyte | 2 2 2 1 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 1 1 2 2 2 2 2 2 2|
Mineralization | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia, Focal, Squamous | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 2| 3| 7| 3| 7| 3| 6| 6| 7| 5| 7| 3| 7| 4| 7| 4| 4| 2| 4| 5| 5| 7| 0| 7| 6|
DAY ON TEST | 9| 6| 0| 6| 3| 3| 9| 6| 3| 8| 0| 6| 3| 2| 2| 2| 6| 9| 4| 7| 4| 3| 3| 2| 3|
| 1| 2| 3| 2| 0| 5| 1| 0| 0| 7| 2| 6| 1| 3| 9| 5| 2| 7| 3| 0| 7| 2| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 3 2 |
Infiltration Cellular, Lymphocyte | 2 1 |
Inflammation, Acute | 2 |
Mucosa, Dilatation | 1 2 2 2 1 2|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation, Chronic | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 2|
Inflammation, Acute | |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Spindle Cell, Hyperplasia | 2 2 2 2 1 2 2 2 2 2 2 1 2 2 2 1 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 2 |
Pigmentation | 2 1 2 1 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M M + M M M M M + + M M M + M + + M + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 |
Inflammation, Acute | |
Follicle, Dilatation | |
Follicle, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Infiltration Cellular, Lymphocyte | 2 2 2|
Inflammation, Acute | 4 |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 2| 3| 7| 3| 7| 3| 6| 6| 7| 5| 7| 3| 7| 4| 7| 4| 4| 2| 4| 5| 5| 7| 0| 7| 6|
DAY ON TEST | 9| 6| 0| 6| 3| 3| 9| 6| 3| 8| 0| 6| 3| 2| 2| 2| 6| 9| 4| 7| 4| 3| 3| 2| 3|
| 1| 2| 3| 2| 0| 5| 1| 0| 0| 7| 2| 6| 1| 3| 9| 5| 2| 7| 3| 0| 7| 2| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Penis | + + + + + + + +|
Inflammation, Acute | 4 3 4 4|
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Inflammation | |
Necrosis | 4 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Abscess | 4 |
Cyst | |
Inflammation, Acute | 2 4 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + M + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 |
Inflammation, Acute | 4 2 3 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + |
Dilatation | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 |
Inflammation, Acute | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Myeloid Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 4 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
Iliac, Hyperplasia, Lymphoid | 2|
Inguinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mesenteric, Autolysis | |
Mesenteric, Congestion | 3 2 |
Mesenteric, Hematopoietic Cell | |
Proliferation | |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Mesenteric, Inflammation, Acute | 2 3 3|
Renal, Hyperplasia, Lymphoid | 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + M M + + + + + + + M + + A + M + M + + + + M + +|
Autolysis | |
Hyperplasia, Lymphoid | 2 2 2 2 1 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 2| 3| 7| 3| 7| 3| 6| 6| 7| 5| 7| 3| 7| 4| 7| 4| 4| 2| 4| 5| 5| 7| 0| 7| 6|
DAY ON TEST | 9| 6| 0| 6| 3| 3| 9| 6| 3| 8| 0| 6| 3| 2| 2| 2| 6| 9| 4| 7| 4| 3| 3| 2| 3|
| 1| 2| 3| 2| 0| 5| 1| 0| 0| 7| 2| 6| 1| 3| 9| 5| 2| 7| 3| 0| 7| 2| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 1 4 2 3 3 2 2 2 2 2 2 2 2 2 3 1 1 2|
Hyperplasia, Lymphoid | 2 2 3 |
Necrosis | 3 |
Pigmentation | 1 2 1 1 2 1 2 2 2 2 1 |
__________________________________________________________________________|
Thymus | + + M + + + + M + + + + + + + M + + + M + + + + +|
Cyst | X |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M + M M M M M M M + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + M +|
Alopecia | 3 |
Ulcer | 4|
Foot, Ulcer | |
Head, Abscess | 4 |
Head, Ulcer | 3 |
Neck, Alopecia | |
Prepuce, Inflammation, Acute | |
Prepuce, Inflammation, Chronic Active| 2 |
Prepuce, Ulcer | 4 4 4 4 |
Scrotal, Abscess | 4 |
Scrotal, Ulcer | 4 4 4 |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Head, Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Inflammation, Chronic Active| 4 |
Femur, Hyperostosis | |
Tibia, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Hemorrhage | |
Mineralization | 2 2 2 2 2 2 2 1 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 2| 3| 7| 3| 7| 3| 6| 6| 7| 5| 7| 3| 7| 4| 7| 4| 4| 2| 4| 5| 5| 7| 0| 7| 6|
DAY ON TEST | 9| 6| 0| 6| 3| 3| 9| 6| 3| 8| 0| 6| 3| 2| 2| 2| 6| 9| 4| 7| 4| 3| 3| 2| 3|
| 1| 2| 3| 2| 0| 5| 1| 0| 0| 7| 2| 6| 1| 3| 9| 5| 2| 7| 3| 0| 7| 2| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Abscess | 3 |
Congestion | 2 2 3 2 4 |
Hemorrhage | 1 |
Infiltration Cellular, Lymphocyte | 2 1 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2|
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Interstitium, Inflammation, Acute | 2 |
Peribronchiolar, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 1 2 2 2 1 2 2 2 2 2 2|
Mucosa, Inflammation, Acute | 1 2 2 |
Olfactory Epithelium, Degeneration | 1 2 2 2 2 2 1 1 2 2 1 2 |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Degeneration | |
Sinus, Inflammation, Acute | 4 |
Turbinate, Congestion | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Cyst | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Infiltration Cellular, Lymphocyte | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Inflammation, Acute | 3 |
Inflammation, Chronic Active | |
Capsule, Inflammation, Chronic | |
Cortex, Cyst | X |
Pelvis, Calculus Micro Observation | |
Only | |
Pelvis, Dilatation | 3 1 |
Pelvis, Hemorrhage | |
Pelvis, Inflammation, Acute | 2 2 3 2|
Pelvis, Inflammation, Chronic Active | |
Renal Tubule, Casts Protein | 1 |
Renal Tubule, Dilatation | 1 1 2 2 1 1 2 2 |
Renal Tubule, Necrosis | 2 1 1 1 2 |
Renal Tubule, Regeneration | 2 1 1 1 1 2 1 |
__________________________________________________________________________|
Urethra | + |
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 109
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 2| 3| 7| 3| 7| 3| 6| 6| 7| 5| 7| 3| 7| 4| 7| 4| 4| 2| 4| 5| 5| 7| 0| 7| 6|
DAY ON TEST | 9| 6| 0| 6| 3| 3| 9| 6| 3| 8| 0| 6| 3| 2| 2| 2| 6| 9| 4| 7| 4| 3| 3| 2| 3|
| 1| 2| 3| 2| 0| 5| 1| 0| 0| 7| 2| 6| 1| 3| 9| 5| 2| 7| 3| 0| 7| 2| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Acute | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | |
Ectasia | 2 3 2 2 2 2 3|
Infiltration Cellular, Lymphocyte | 1 2 2 1 2 2 2 2 2 2 2 2 2 2|
Inflammation, Acute | 4 4 3 2|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 110
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 6| 6| 7| 7| 7| 5| 5| 7| 4| 4| 5| 5| 7| 5| 7| 7| 5| 5| 7| 6|
DAY ON TEST | 3| 3| 3| 5| 3| 8| 3| 2| 2| 3| 2| 1| 2| 2| 6| 6| 6| 1| 7| 2| 3| 7| 2| 3| 3|
| 2| 0| 2| 6| 0| 0| 9| 1| 9| 0| 4| 0| 0| 8| 7| 5| 5| 6| 1| 9| 3| 2| 8| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Anorectal Junction, Inflammation, | |
Acute | |
Anus, Erosion | |
Anus, Ulcer | 4 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M + + + + + + + + + + + + + + + + + + +|
Anorectal Junction, Ulcer | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Cyst | |
Hematopoietic Cell Proliferation | 2 1 2 1 2 2 1 1|
Hyperplasia | |
Hypertrophy | |
Infarct | 4 |
Infiltration Cellular, Lymphocyte | 1 1 |
Inflammation, Acute | |
Necrosis | 2 3 2 |
Bile Duct, Hyperplasia | |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infiltration Cellular, Lymphocyte | 1 2 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 2 2 2 2 2 2 2 2 2 2 2 2|
Mineralization | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hyperplasia, Focal, Squamous | 3 |
Infiltration Cellular, Lymphocyte | 1|
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
Page 111
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 6| 6| 7| 7| 7| 5| 5| 7| 4| 4| 5| 5| 7| 5| 7| 7| 5| 5| 7| 6|
DAY ON TEST | 3| 3| 3| 5| 3| 8| 3| 2| 2| 3| 2| 1| 2| 2| 6| 6| 6| 1| 7| 2| 3| 7| 2| 3| 3|
| 2| 0| 2| 6| 0| 0| 9| 1| 9| 0| 4| 0| 0| 8| 7| 5| 5| 6| 1| 9| 3| 2| 8| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 2 2 2 1|
Inflammation, Acute | 2 |
Mucosa, Dilatation | 2 1 1 1 1 1 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation, Chronic | 3 |
Aorta, Mineralization | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 2 |
Inflammation, Acute | 3 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Spindle Cell, Hyperplasia | 2 2 1 2 2 2 2 2 2 2 1 2 2 1 2 2 2 2 3 2 1 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 2 |
Pigmentation | 2 1 2 2 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M M M M + + M M M + M M M + + + + M M + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Intermedia, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Acute | |
Follicle, Dilatation | 3 2 3|
Follicle, Hyperplasia | 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Acute | 3 4 |
_____________________________________________________________________________________________________________________|
Page 112
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 6| 6| 7| 7| 7| 5| 5| 7| 4| 4| 5| 5| 7| 5| 7| 7| 5| 5| 7| 6|
DAY ON TEST | 3| 3| 3| 5| 3| 8| 3| 2| 2| 3| 2| 1| 2| 2| 6| 6| 6| 1| 7| 2| 3| 7| 2| 3| 3|
| 2| 0| 2| 6| 0| 0| 9| 1| 9| 0| 4| 0| 0| 8| 7| 5| 5| 6| 1| 9| 3| 2| 8| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 1 4 |
__________________________________________________________________________|
Penis | + + + + + + + + |
Inflammation, Acute | 2 4 4 2 4 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
Inflammation | 4 |
Necrosis | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + |
Abscess | 4 |
Cyst | X |
Inflammation, Acute | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 1 2 2 |
Inflammation, Acute | 4 3 4 3 2 4 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + |
Dilatation | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Myeloid Cell, Hyperplasia | 3 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
Iliac, Hyperplasia, Lymphoid | 3 3 |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | 2 2 2 |
Mesenteric, Autolysis | |
Mesenteric, Congestion | 3 3 2 4 3 2 2 2 |
Mesenteric, Hematopoietic Cell | |
Proliferation | 3 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 2 2 3 2 2 2 |
Mesenteric, Inflammation, Acute | 2 3 2 3 2 3 |
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 113
NTP Experiment-Test: 05701-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:24:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 6| 6| 7| 7| 7| 5| 5| 7| 4| 4| 5| 5| 7| 5| 7| 7| 5| 5| 7| 6|
DAY ON TEST | 3| 3| 3| 5| 3| 8| 3| 2| 2| 3| 2| 1| 2| 2| 6| 6| 6| 1| 7| 2| 3| 7| 2| 3| 3|
| 2| 0| 2| 6| 0| 0| 9| 1| 9| 0| 4| 0| 0| 8| 7| 5| 5| 6| 1| 9| 3| 2| 8| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Hyperplasia, Lymphoid | 2 4 |
Necrosis | 4 |
Pigmentation | 2 1 2 1 1 1 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +|
Cyst | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin