TR 371 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/18/94
EXP: 05701 TOLUENE TIME: 15:06:18
TEST: 03 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 07272B
CONT: 0570101 CAS: 108883
PATHOLOGIST: J. SAGARTZ
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/18/94
EXP: 05701 TOLUENE TIME: 15:06:18
TEST: 03 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 07272B
CONT: 0570101 CAS: 108883
PATHOLOGIST: J. SAGARTZ
TOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 42 CENSORED DEATHS 1 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 291 291 291 331 372 388 429 434 436 438 |
| 442 443 443 446 470 491 520 526 528 534 |
| 543 549 549 557 563 576 579 590 604 608 |
| 613 618 629 629 633 633 639 640 669 701 |
| 713 713 |
| CENSORED DEATHS |
| 712 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 120 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 38 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 155 388 393 400 416 435 443 454 498 501 |
| 501 509 525 526 531 556 556 562 564 571 |
| 577 583 590 593 607 611 611 619 633 633 |
| 633 639 639 640 660 687 716 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 600 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 42 CENSORED DEATHS 2 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 229 277 278 306 319 323 331 374 379 390 |
| 405 418 425 430 430 443 448 450 452 470 |
| 473 485 508 518 551 555 563 563 563 569 |
| 576 577 619 632 639 639 639 674 689 716 |
| 724 725 |
| CENSORED DEATHS |
| 500 554 |
| |
==================================================================================
TOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1200 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 39 CENSORED DEATHS 2 TERMINAL 19 |
| |
| UNCENSORED DEATHS |
| 34 156 291 297 335 362 362 366 423 425 |
| 428 443 462 463 467 510 524 524 528 530 |
| 547 547 570 571 572 587 633 638 639 639 |
| 660 680 691 694 702 703 716 720 721 |
| CENSORED DEATHS |
| 565 565 |
| |
==================================================================================
TOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 93.3 90.0 75.0 65.0 51.7 36.7 29.8 |
| | |
| | |
|120 PPM | 100.0 98.3 98.3 98.3 91.7 86.7 75.0 60.0 41.7 36.7 |
| | |
| | |
|600 PPM | 100.0 100.0 98.3 88.3 78.3 63.3 59.9 45.9 37.0 28.2 |
| | |
| | |
|1200 PPM | 98.3 96.7 96.7 88.3 83.3 75.0 66.7 56.3 47.5 33.4 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 120 PPM 600 PPM 1200 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 29.8% 36.7% 28.2% 33.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000 P=0.358N P=0.744 P=0.662N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 526.0 549.4 494.6 516.9 |
|NATURAL DEATHS (C) | (17.8) (17.8) (20.5) (25.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 586.6 615.3 558.2 585.7 |
|(STANDARD ERROR) | (17.3) (15.9) (19.6) (21.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 19 CENSORED DEATHS 11 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 4 375 393 463 556 624 631 634 636 653 |
| 681 683 693 709 710 714 716 716 722 |
| CENSORED DEATHS |
| 347 457 457 457 457 457 457 457 457 457 |
| 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 120 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 14 CENSORED DEATHS 13 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 8 430 452 458 477 534 599 646 653 683 |
| 686 687 690 722 |
| CENSORED DEATHS |
| 388 388 388 457 457 457 457 457 457 457 |
| 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 600 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 26 CENSORED DEATHS 10 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 163 398 505 509 518 562 578 598 601 605 |
| 627 629 641 650 653 659 660 669 699 702 |
| 708 708 709 712 713 725 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
TOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1200 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 14 CENSORED DEATHS 14 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 3 82 400 520 523 589 594 598 621 670 |
| 696 709 715 716 |
| CENSORED DEATHS |
| 229 457 457 457 457 457 457 457 457 457 |
| 457 488 488 488 |
| |
==================================================================================
TOLUENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 98.3 98.3 98.3 98.3 94.9 92.9 92.9 90.8 80.5 61.9 |
| | |
| | |
|120 PPM | 98.3 98.3 98.3 98.3 98.3 90.5 88.4 86.2 81.9 71.1 |
| | |
| | |
|600 PPM | 100.0 98.3 98.3 98.3 96.7 96.7 90.6 80.6 66.5 48.3 |
| | |
| | |
|1200 PPM | 96.7 96.7 96.7 96.7 95.0 95.0 90.6 83.9 81.7 70.7 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 120 PPM 600 PPM 1200 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 61.9% 71.1% 48.3% 70.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.991N P=0.525N P=0.209 P=0.572N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 595.4 551.8 611.6 531.1 |
|NATURAL DEATHS (C) | (41.1) (50.2) (23.9) (60.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 635.0 625.3 632.8 617.1 |
|(STANDARD ERROR) | (19.0) (19.5) (16.1) (21.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TOLUENE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
120 PPM = 2
600 PPM = 3
1200 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 3 1
| 4 2 3 3 4 22
| 3 143 1 22
| 43 331 4 1 1 2 2 2
90 + 33 1 122
| 3 443 3 4112 2 2
| 33
| 3 3 34411 22
P 80 + 33 4 4 2 2
E | 33 1 441 22
R | 3 3 41 1 4 2 2
C | 3 3 1 4 11 22
E 70 + 44
N | 3 3 1114 222
T | 3 3 11 22
| 3 33 11 4 2 2
S 60 + 3 311 2 2
U | 331414 22 4
R | 1 1 22 44
V | 1 1 2 2
I 50 + 333 11 4 4
V | 11122 4 4
A | 3 3 3 444
L | 112 2 244
40 + 11 2 2
| 1 13 4 22 2
| 13 3 1
| 3 1133 4
30 + 1 1
| 3 3
|
|
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 40 obs hidden.
TOLUENE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
120 PPM = 2
600 PPM = 3
1200 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 112 3
| 12 4 3 1 14 2 2 3
| 14 221 4
| 21 2 33 1
P 90 + 2 3 4 2 13 4 11
E | 2 3 3 2
R | 42 4 22
C | 33 4 1 1 4 2
E 80 + 3 3 1 4 1 4
N | 3 3 114 4
T | 33 1 14
| 33 2 2
S 70 + 3 3 42 2
U | 33 11
R | 3 3 11
V | 33 1 1
I 60 + 33
V |
A |
L |
50 + 3 3
| 3 3
|
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 21 obs hidden.
--multipart-boundary
Content-type: text/plain
Range: bytes 29677-29677/29677
--multipart-boundary--