TR 371 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
TOLUENE
NTP Experiment-Test: 05701-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
Facility: International Research and Development Corp.
Chemical CAS #: 108883
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Dead 6 7 6
Moribund 11 8 14
Survivors
Terminal Sacrifice 32 35 30
Dead 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (50) (49)
Inflammation, Chronic 1 (2%)
Intestine Large, Cecum (50) (49) (49)
Inflammation, Acute 1 (2%) 2 (4%)
Intestine Large, Colon (50) (49) (49)
Inflammation, Acute 1 (2%)
Parasite Metazoan 5 (10%) 1 (2%) 2 (4%)
Intestine Large, Rectum (50) (50) (48)
Parasite Metazoan 4 (8%) 5 (10%)
Ulcer 1 (2%) 1 (2%)
Intestine Small, Duodenum (50) (49) (49)
Edema 1 (2%)
Erosion 1 (2%) 1 (2%) 1 (2%)
Intestine Small, Ileum (50) (49) (49)
Edema 1 (2%)
Ulcer 1 (2%)
Intestine Small, Jejunum (50) (49) (49)
Edema 1 (2%)
Liver (50) (50) (50)
Angiectasis 2 (4%) 6 (12%) 6 (12%)
Congestion 1 (2%)
Developmental Malformation 6 (12%) 5 (10%) 5 (10%)
Fatty Change 3 (6%) 3 (6%) 2 (4%)
Focal Cellular Change 29 (58%) 41 (82%) 41 (82%)
Granuloma 12 (24%) 13 (26%) 10 (20%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%) 2 (4%)
Hemorrhage 1 (2%) 1 (2%)
Necrosis 4 (8%) 1 (2%)
Arteriole, Thrombosis 1 (2%)
Bile Duct, Hyperplasia 38 (76%) 36 (72%) 31 (62%)
Portal, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Portal, Inflammation, Chronic 47 (94%) 46 (92%) 40 (80%)
Portal, Inflammation, Chronic Active 1 (2%)
Venule, Thrombosis 1 (2%)
Mesentery (1) (1) (2)
Fat, Necrosis 1 (100%) 1 (100%) 1 (50%)
Pancreas (50) (49) (50)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic Active 1 (2%)
Acinus, Atrophy 18 (36%) 24 (49%) 15 (30%)
Acinus, Hyperplasia 1 (2%) 4 (8%)
Acinus, Vacuolization Cytoplasmic 1 (2%)
Arteriole, Inflammation, Chronic 1 (2%)
Duct, Ectasia 1 (2%)
Salivary Glands (50) (50) (50)
Infiltration Cellular, Lymphocyte 1 (2%)
Acinus, Atrophy 1 (2%)
Stomach, Forestomach (50) (50) (50)
Hyperkeratosis 1 (2%)
Hyperplasia, Squamous 1 (2%) 2 (4%) 4 (8%)
Inflammation, Acute 3 (6%)
Inflammation, Chronic Active 2 (4%) 1 (2%) 3 (6%)
Ulcer 6 (12%) 5 (10%) 9 (18%)
Stomach, Glandular (50) (50) (50)
Foreign Body 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic Active 2 (4%)
Mucosa, Dilatation 27 (54%) 26 (52%) 28 (56%)
Mucosa, Erosion 6 (12%) 4 (8%) 5 (10%)
Mucosa, Mineralization 1 (2%)
Mucosa, Pigmentation 1 (2%)
Mucosa, Ulcer 2 (4%)
Serosa, Inflammation, Chronic Active 1 (2%)
Tooth (1) (2)
Peridontal Tissue, Inflammation, Chronic 1 (50%)
Pulp, Inflammation, Chronic 1 (50%)
Pulp, Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50)
Aorta, Mineralization 1 (2%)
Heart (50) (50) (50)
Cardiomyopathy, Chronic 48 (96%) 50 (100%) 47 (94%)
Inflammation, Acute 1 (2%)
Mineralization 1 (2%) 1 (2%)
Artery, Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Atrium, Thrombosis 2 (4%) 1 (2%) 1 (2%)
Ventricle, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (49) (49)
Congestion 1 (2%)
Degeneration, Fatty 33 (66%) 31 (63%) 37 (76%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 16 (32%) 19 (39%) 9 (18%)
Hypertrophy 4 (8%) 9 (18%) 4 (8%)
Inflammation, Chronic 1 (2%)
Pigmentation 50 (100%) 48 (98%) 48 (98%)
Adrenal Gland, Medulla (49) (48) (49)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 4 (8%) 4 (8%) 6 (12%)
Islets, Pancreatic (50) (49) (50)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (42) (44) (41)
Hypertrophy 1 (2%)
Pituitary Gland (50) (50) (50)
Pars Distalis, Angiectasis 1 (2%) 3 (6%) 1 (2%)
Pars Distalis, Congestion 1 (2%)
Pars Distalis, Cyst 10 (20%) 14 (28%) 11 (22%)
Pars Distalis, Hemorrhage 3 (6%) 1 (2%)
Pars Distalis, Hyperplasia 7 (14%) 17 (34%) 7 (14%)
Pars Distalis, Metaplasia, Osseous 1 (2%)
Pars Intermedia, Angiectasis 1 (2%) 2 (4%) 2 (4%)
Pars Intermedia, Cyst 1 (2%)
Pars Nervosa, Cyst 1 (2%)
Thyroid Gland (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (2%)
Ultimobranchial Cyst 1 (2%) 2 (4%)
C-Cell, Hyperplasia 17 (34%) 23 (46%) 15 (30%)
Follicle, Ectasia 4 (8%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (50) (44)
Cyst 1 (2%)
Hyperplasia 2 (4%) 2 (5%)
Inflammation, Acute 1 (2%) 2 (5%)
Inflammation, Chronic 21 (43%) 20 (40%) 21 (48%)
Inflammation, Chronic Active 10 (20%) 14 (28%) 7 (16%)
Duct, Ectasia 2 (4%) 1 (2%)
Duct, Hyperplasia, Squamous 1 (2%)
Ovary (50) (50) (50)
Follicle, Cyst 1 (2%)
Periovarian Tissue, Cyst 2 (4%) 1 (2%) 2 (4%)
Uterus (50) (50) (50)
Ectasia 2 (4%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Prolapse 1 (2%)
Endometrium, Ectasia 1 (2%)
Endometrium, Hyperplasia, Cystic 2 (4%) 2 (4%) 7 (14%)
Endometrium, Inflammation, Chronic 1 (2%) 1 (2%)
Myometrium, Inflammation, Chronic 1 (2%)
Vagina (4) (4) (3)
Inflammation, Acute 1 (33%)
Inflammation, Chronic Active 1 (25%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50)
Hyperplasia 1 (2%)
Myelofibrosis 8 (16%) 9 (18%) 4 (8%)
Myeloid Cell, Hyperplasia 1 (2%)
Lymph Node (50) (50) (50)
Congestion 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 6 (12%) 3 (6%) 10 (20%)
Inflammation, Acute 1 (2%) 1 (2%)
Pigmentation 1 (2%)
Mediastinal, Congestion 1 (2%)
Mediastinal, Hemorrhage 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Mediastinal, Pigmentation 1 (2%)
Mesenteric, Congestion 4 (8%) 3 (6%) 4 (8%)
Mesenteric, Edema 1 (2%)
Mesenteric, Hyperplasia, Lymphoid 17 (34%) 32 (64%) 29 (58%)
Mesenteric, Inflammation, Acute 1 (2%) 1 (2%)
Renal, Congestion 1 (2%)
Lymph Node, Mandibular (47) (48) (42)
Congestion 5 (11%) 8 (17%) 3 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Cyst 1 (2%) 1 (2%) 2 (5%)
Hyperplasia, Lymphoid 41 (87%) 42 (88%) 39 (93%)
Inflammation, Acute 1 (2%) 1 (2%)
Spleen (50) (50) (50)
Fibrosis 3 (6%) 3 (6%)
Hematopoietic Cell Proliferation 41 (82%) 46 (92%) 44 (88%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Reticulum Cell 1 (2%)
Infarct 1 (2%) 1 (2%)
Pigmentation 44 (88%) 44 (88%) 47 (94%)
Capsule, Fibrosis 2 (4%)
Capsule, Inflammation, Acute 1 (2%)
Thymus (46) (46) (46)
Congestion 4 (9%) 2 (4%) 1 (2%)
Cyst 2 (4%) 2 (4%) 3 (7%)
Hyperplasia, Lymphoid 3 (7%) 1 (2%)
Mediastinum, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Acinus, Ectasia 37 (74%) 34 (68%) 27 (54%)
Acinus, Hyperplasia 3 (6%) 1 (2%)
Acinus, Hyperplasia, Cystic 1 (2%)
Duct, Ectasia 21 (42%) 31 (62%) 23 (46%)
Skin (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Head, Inflammation, Chronic Active 1 (2%) 1 (2%)
Head, Ulcer 1 (2%)
Lip, Inflammation, Chronic Active 1 (2%)
Subcutaneous Tissue, Abscess 1 (2%)
Subcutaneous Tissue, Head, Abscess 1 (2%)
Subcutaneous Tissue, Head, Granuloma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (50)
Cranium, Fibrous Osteodystrophy 1 (2%) 2 (4%)
Cranium, Osteopetrosis 2 (4%) 1 (2%)
Femur, Fibrous Osteodystrophy 1 (2%) 4 (8%)
Femur, Osteopetrosis 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49)
Compression 11 (22%) 6 (12%) 13 (27%)
Gliosis 1 (2%)
Hemorrhage 5 (10%) 6 (12%) 3 (6%)
Hydrocephalus 1 (2%) 2 (4%)
Lateral Ventricle, Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Congestion 5 (10%) 5 (10%) 6 (12%)
Hemorrhage 7 (14%) 7 (14%) 4 (8%)
Infiltration Cellular 1 (2%)
Infiltration Cellular, Lymphocyte 49 (98%) 49 (98%) 50 (100%)
Metaplasia, Osseous 1 (2%)
Pigmentation, Cholesterol 1 (2%) 2 (4%)
Alveolar Epithelium, Hyperplasia 1 (2%) 2 (4%)
Alveolus, Infiltration Cellular, Histiocyte 28 (56%) 20 (40%) 36 (72%)
Alveolus, Mineralization 1 (2%)
Arteriole, Mineralization 25 (50%) 30 (60%) 26 (52%)
Interstitium, Inflammation, Chronic 17 (34%) 9 (18%) 2 (4%)
Interstitium, Inflammation, Chronic Active 1 (2%) 2 (4%) 4 (8%)
Peribronchiolar, Inflammation, Acute 2 (4%) 1 (2%)
Peribronchiolar, Inflammation, Chronic 5 (10%) 1 (2%)
Peribronchiolar, Inflammation, Chronic Active 1 (2%)
Pleura, Fibrosis 1 (2%)
Smooth Muscle, Hyperplasia 1 (2%)
Nose (49) (50) (50)
Glands, Hyperplasia 1 (2%)
Lumen, Foreign Body 4 (8%) 1 (2%) 1 (2%)
Lumen, Hemorrhage 30 (61%) 34 (68%) 32 (64%)
Mucosa, Inflammation 1 (2%)
Mucosa, Inflammation, Acute 27 (55%) 41 (82%) 41 (82%)
Nasolacrimal Duct, Hemorrhage 1 (2%)
Nasolacrimal Duct, Inflammation, Acute 5 (10%) 2 (4%) 6 (12%)
Nasolacrimal Duct, Inflammation, Chronic
Active 1 (2%)
Olfactory Epithelium, Degeneration 44 (90%) 48 (96%) 47 (94%)
Olfactory Epithelium, Erosion 2 (4%) 11 (22%) 10 (20%)
Olfactory Epithelium, Hemorrhage 1 (2%)
Olfactory Epithelium, Metaplasia 1 (2%) 5 (10%)
Olfactory Epithelium, Metaplasia, Squamous 1 (2%) 1 (2%)
Respiratory Epithelium, Degeneration 29 (59%) 45 (90%) 39 (78%)
Respiratory Epithelium, Erosion 4 (8%) 1 (2%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 1 (2%)
Trachea (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (5) (4) (3)
Atrophy 1 (20%) 1 (25%)
Cataract 3 (60%) 2 (50%) 2 (67%)
Hemorrhage 1 (25%)
Anterior Chamber, Hemorrhage 1 (33%)
Lids, Inflammation, Chronic Active 1 (33%)
Retina, Degeneration 4 (80%) 3 (75%) 2 (67%)
Sclera, Mineralization 2 (40%) 2 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Hydronephrosis 1 (2%)
Inflammation, Acute 1 (2%)
Nephropathy, Chronic 49 (98%) 48 (96%) 49 (98%)
Capsule, Inflammation, Chronic 1 (2%)
Pelvis, Calculus Micro Observation Only 1 (2%) 1 (2%)
Renal Tubule, Cyst 2 (4%) 1 (2%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%)
Renal Tubule, Hypertrophy 1 (2%)
Renal Tubule, Pigmentation 49 (98%) 50 (100%) 48 (96%)
Urinary Bladder (50) (50) (50)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 14 11 23
Dead 6 8 5
Natural Death 3
Survivors
Terminal Sacrifice 29 27 22
Dead 1
Accident 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (50) (49)
Erosion 1 (2%)
Hemorrhage 2 (4%)
Inflammation, Acute 1 (2%)
Intestine Large, Colon (50) (50) (49)
Granuloma 1 (2%)
Parasite Metazoan 2 (4%) 4 (8%) 1 (2%)
Intestine Large, Rectum (49) (50) (49)
Erosion 1 (2%)
Inflammation, Acute 1 (2%)
Parasite Metazoan 2 (4%) 4 (8%) 7 (14%)
Ulcer 4 (8%) 3 (6%)
Intestine Small, Duodenum (50) (50) (49)
Erosion 1 (2%)
Ulcer 1 (2%)
Intestine Small, Ileum (49) (50) (49)
Erosion 1 (2%)
Liver (50) (50) (50)
Angiectasis 7 (14%) 11 (22%) 3 (6%)
Congestion 3 (6%) 2 (4%) 1 (2%)
Developmental Malformation 1 (2%) 4 (8%) 2 (4%)
Fatty Change 3 (6%) 2 (4%) 8 (16%)
Focal Cellular Change 28 (56%) 23 (46%) 23 (46%)
Granuloma 1 (2%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 2 (4%)
Hemorrhage 2 (4%)
Necrosis 2 (4%) 2 (4%) 1 (2%)
Bile Duct, Dilatation 1 (2%)
Bile Duct, Hyperplasia 48 (96%) 49 (98%) 49 (98%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Bile Duct, Inflammation, Chronic 1 (2%)
Portal, Inflammation, Chronic 48 (96%) 45 (90%) 46 (92%)
Serosa, Fibrosis 1 (2%)
Mesentery (2) (2) (4)
Inflammation, Acute 1 (50%)
Arteriole, Inflammation, Chronic 2 (50%)
Arteriole, Inflammation, Chronic Active 1 (25%)
Fat, Necrosis 2 (100%) 1 (25%)
Pancreas (50) (50) (50)
Inflammation, Acute 1 (2%)
Acinus, Atrophy 30 (60%) 34 (68%) 30 (60%)
Acinus, Hyperplasia 1 (2%) 4 (8%) 1 (2%)
Arteriole, Inflammation, Chronic Active 1 (2%)
Arteriole, Mineralization 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Salivary Glands (50) (50) (50)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Acinus, Atrophy 1 (2%) 1 (2%)
Arteriole, Mineralization 1 (2%)
Stomach (50) (50) (50)
Ulcer 1 (2%)
Stomach, Forestomach (50) (50) (49)
Cyst 1 (2%)
Erosion 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Squamous 2 (4%) 1 (2%) 2 (4%)
Inflammation, Acute 4 (8%) 3 (6%) 2 (4%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 3 (6%) 2 (4%) 2 (4%)
Mineralization 1 (2%)
Ulcer 4 (8%) 7 (14%) 9 (18%)
Stomach, Glandular (50) (50) (49)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 2 (4%)
Mucosa, Congestion 1 (2%)
Mucosa, Dilatation 17 (34%) 21 (42%) 18 (37%)
Mucosa, Ectasia 2 (4%)
Mucosa, Erosion 4 (8%) 11 (22%) 9 (18%)
Mucosa, Granuloma 1 (2%)
Mucosa, Hemorrhage 1 (2%)
Mucosa, Inflammation, Acute 1 (2%)
Mucosa, Ulcer 2 (4%) 5 (10%) 3 (6%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50)
Aorta, Mineralization 1 (2%)
Thoracic, Inflammation, Chronic Active 1 (2%)
Heart (50) (50) (50)
Cardiomyopathy, Chronic 49 (98%) 47 (94%) 47 (94%)
Hemorrhage 1 (2%)
Mineralization 1 (2%)
Artery, Mineralization 1 (2%)
Atrium, Thrombosis 6 (12%) 3 (6%)
Pericardium, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Degeneration, Fatty 35 (70%) 41 (82%) 43 (86%)
Hyperplasia 15 (30%) 10 (20%) 11 (22%)
Hypertrophy 4 (8%) 5 (10%) 3 (6%)
Pigmentation 43 (86%) 46 (92%) 39 (78%)
Adrenal Gland, Medulla (49) (50) (50)
Hyperplasia 10 (20%) 15 (30%) 4 (8%)
Islets, Pancreatic (50) (50) (50)
Hyperplasia 1 (2%) 4 (8%) 3 (6%)
Parathyroid Gland (42) (45) (44)
Hyperplasia 2 (5%) 1 (2%) 1 (2%)
Hypertrophy 2 (4%)
Pituitary Gland (49) (50) (50)
Pars Distalis, Angiectasis 3 (6%) 1 (2%)
Pars Distalis, Atrophy 1 (2%)
Pars Distalis, Cyst 3 (6%) 6 (12%) 5 (10%)
Pars Distalis, Hemorrhage 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 18 (37%) 22 (44%) 11 (22%)
Pars Intermedia, Angiectasis 2 (4%) 1 (2%)
Pars Intermedia, Cyst 2 (4%) 2 (4%) 1 (2%)
Pars Intermedia, Hyperplasia 2 (4%)
Pars Nervosa, Pigmentation 1 (2%)
Thyroid Gland (50) (50) (50)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Ultimobranchial Cyst 1 (2%) 2 (4%)
C-Cell, Hyperplasia 12 (24%) 20 (40%) 14 (28%)
Follicle, Ectasia 3 (6%) 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (50) (50) (50)
Abscess 3 (6%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 29 (58%) 28 (56%) 22 (44%)
Inflammation, Chronic Active 10 (20%) 17 (34%) 25 (50%)
Mineralization 1 (2%)
Duct, Ectasia 1 (2%) 2 (4%)
Prostate (50) (50) (50)
Atrophy 1 (2%)
Hyperplasia 10 (20%) 3 (6%) 3 (6%)
Inflammation, Acute 7 (14%) 7 (14%) 5 (10%)
Inflammation, Chronic 1 (2%) 3 (6%) 2 (4%)
Inflammation, Chronic Active 14 (28%) 6 (12%) 10 (20%)
Seminal Vesicle (5)
Dilatation 1 (20%)
Testes (50) (50) (50)
Atrophy 11 (22%) 12 (24%) 9 (18%)
Congestion 1 (2%)
Mineralization 2 (4%)
Arteriole, Inflammation, Chronic 2 (4%) 1 (2%)
Interstitial Cell, Hyperplasia 35 (70%) 46 (92%) 37 (74%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Myelofibrosis 3 (6%) 1 (2%) 5 (10%)
Lymph Node (50) (50) (50)
Congestion 1 (2%)
Edema 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Mediastinal, Congestion 1 (2%) 5 (10%)
Mediastinal, Hemorrhage 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Mesenteric, Congestion 1 (2%) 1 (2%) 4 (8%)
Mesenteric, Hyperplasia, Lymphoid 17 (34%) 20 (40%) 22 (44%)
Mesenteric, Inflammation, Acute 1 (2%)
Popliteal, Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mandibular (36) (45) (37)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Congestion 10 (28%) 10 (22%) 3 (8%)
Cyst 1 (3%) 1 (2%) 1 (3%)
Hyperplasia, Lymphoid 32 (89%) 31 (69%) 30 (81%)
Spleen (50) (50) (50)
Fibrosis 5 (10%) 3 (6%) 4 (8%)
Hematopoietic Cell Proliferation 42 (84%) 42 (84%) 40 (80%)
Hyperplasia, Lymphoid 2 (4%) 3 (6%)
Infarct 1 (2%)
Mineralization 1 (2%)
Pigmentation 39 (78%) 37 (74%) 42 (84%)
Thymus (44) (46) (46)
Congestion 2 (5%) 5 (11%) 1 (2%)
Cyst 4 (9%) 1 (2%)
Hyperplasia, Lymphoid 4 (9%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (48) (49)
Inflammation, Acute 2 (4%)
Inflammation, Chronic 1 (2%)
Acinus, Ectasia 34 (68%) 25 (52%) 28 (57%)
Duct, Ectasia 10 (20%) 19 (40%) 8 (16%)
Skin (50) (50) (50)
Abscess 1 (2%) 1 (2%)
Cyst Epithelial Inclusion 1 (2%) 2 (4%)
Epidermis, Cyst 1 (2%)
Foot, Ulcer 1 (2%)
Hair Follicle, Inflammation, Chronic 1 (2%)
Hair Follicle, Head, Hemorrhage 1 (2%)
Hair Follicle, Head, Inflammation, Acute 1 (2%)
Head, Abscess 1 (2%)
Head, Inflammation, Acute 1 (2%) 1 (2%) 1 (2%)
Head, Inflammation, Chronic Active 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
Tail, Inflammation, Chronic Active 1 (2%)
Tail, Subcutaneous Tissue, Inflammation,
Acute 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Cranium, Abscess 1 (2%)
Cranium, Fibrous Osteodystrophy 1 (2%) 1 (2%) 2 (4%)
Cranium, Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Femur, Fibrous Osteodystrophy 1 (2%) 4 (8%) 2 (4%)
Humerus, Fracture 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Compression 5 (10%) 7 (14%) 6 (12%)
Hemorrhage 11 (22%) 8 (16%) 2 (4%)
Necrosis 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Congestion 6 (12%) 3 (6%) 4 (8%)
Hemorrhage 8 (16%) 4 (8%) 5 (10%)
Infiltration Cellular, Lymphocyte 50 (100%) 47 (94%) 49 (98%)
Inflammation, Chronic 1 (2%)
Metaplasia, Osseous 1 (2%)
Pigmentation, Cholesterol 1 (2%) 2 (4%) 2 (4%)
Alveolar Epithelium, Hyperplasia 2 (4%) 2 (4%) 3 (6%)
Alveolus, Infiltration Cellular, Histiocyte 26 (52%) 18 (36%) 25 (50%)
Alveolus, Mineralization 2 (4%)
Arteriole, Mineralization 41 (82%) 40 (80%) 38 (76%)
Bronchiole, Inflammation, Acute 2 (4%)
Bronchiole, Mineralization 1 (2%)
Interstitium, Inflammation, Chronic 5 (10%) 6 (12%) 10 (20%)
Interstitium, Inflammation, Chronic Active 5 (10%) 2 (4%)
Peribronchiolar, Inflammation, Chronic 3 (6%)
Peribronchiolar, Inflammation, Chronic Active 1 (2%)
Pleura, Inflammation, Chronic Active 1 (2%)
Nose (50) (50) (49)
Inflammation, Chronic Active 1 (2%)
Lumen, Degeneration 1 (2%)
Lumen, Foreign Body 4 (8%) 5 (10%) 2 (4%)
Lumen, Hemorrhage 31 (62%) 25 (50%) 35 (71%)
Mucosa, Hemorrhage 1 (2%)
Mucosa, Inflammation, Acute 30 (60%) 30 (60%) 40 (82%)
Mucosa, Inflammation, Chronic Active 1 (2%)
Nasolacrimal Duct, Degeneration 1 (2%)
Nasolacrimal Duct, Inflammation 1 (2%)
Nasolacrimal Duct, Inflammation, Acute 4 (8%) 1 (2%) 2 (4%)
Nasopharyngeal Duct, Inflammation, Acute 1 (2%)
Olfactory Epithelium, Degeneration 39 (78%) 48 (96%) 42 (86%)
Olfactory Epithelium, Erosion 3 (6%) 8 (16%)
Olfactory Epithelium, Metaplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05701-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOLUENE Date: 09/18/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:18
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 600 PPM 1200 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Olfactory Epithelium, Metaplasia, Squamous 2 (4%)
Respiratory Epithelium, Degeneration 15 (30%) 37 (74%) 31 (63%)
Respiratory Epithelium, Erosion 4 (8%) 6 (12%) 3 (6%)
Respiratory Epithelium, Hemorrhage 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 1 (2%)
Respiratory Epithelium, Ulcer 1 (2%)
Vomeronasal Organ, Inflammation, Acute 1 (2%) 1 (2%)
Trachea (50) (50) (50)
Inflammation, Acute 1 (2%) 3 (6%)
Inflammation, Chronic Active 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (2)
Cataract 1 (50%) 2 (100%)
Retina, Degeneration 1 (50%) 1 (50%)
Sclera, Mineralization 1 (50%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Congestion 1 (2%)
Infarct 2 (4%)
Infiltration Cellular, Lymphocyte 1 (2%)
Mineralization 1 (2%)
Nephropathy, Chronic 49 (98%) 48 (96%) 48 (96%)
Pelvis, Inflammation, Acute 1 (2%) 1 (2%)
Renal Tubule, Cyst 1 (2%) 2 (4%) 5 (10%)
Renal Tubule, Hyperplasia 4 (8%) 4 (8%)
Renal Tubule, Pigmentation 50 (100%) 48 (96%) 47 (94%)
Urinary Bladder (50) (50) (50)
Calculus Gross Observation 1 (2%)
Calculus Micro Observation Only 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (4%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
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