TR 371 Rat Pathology Tables
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
Facility: International Research and Development Corp.
Chemical CAS #: 108883
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 5| 2| 3| 2| 3| 5| 1| 0| 3| 5| 2| 4| 1| 3| 2| 3| 3| 3| 3|
| 0| 2| 8| 3| 0| 2| 9| 9| 0| 6| 2| 8| 0| 8| 1| 8| 9| 4| 9| 8| 9| 3| 2| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M +|
Carcinoma, Metastatic, Thyroid Gland | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
Pheochromocytoma NOS | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X |
Pars Distalis, Leukemia Mononuclear | |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 5| 2| 3| 2| 3| 5| 1| 0| 3| 5| 2| 4| 1| 3| 2| 3| 3| 3| 3|
| 0| 2| 8| 3| 0| 2| 9| 9| 0| 6| 2| 8| 0| 8| 1| 8| 9| 4| 9| 8| 9| 3| 2| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
Endometrium, Polyp Stromal | X |
Endometrium, Sarcoma Stromal | X |
__________________________________________________________________________|
Vagina | + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
Mediastinal, Leukemia Mononuclear | |
Mesenteric, Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M M + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + M + + + + +|
Leukemia Mononuclear | X |
Thymoma Benign | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Adenoma | X X |
Fibroadenoma | X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 5| 2| 3| 2| 3| 5| 1| 0| 3| 5| 2| 4| 1| 3| 2| 3| 3| 3| 3|
| 0| 2| 8| 3| 0| 2| 9| 9| 0| 6| 2| 8| 0| 8| 1| 8| 9| 4| 9| 8| 9| 3| 2| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Transitional Epithelium, Papilloma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 4| 6| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 3| 3| 5| 3| 9| 7| 3| 3| 3| 5| 2| 2| 3| 3| 3| 6| 5| 7| 5| 3| 3| 3| 3| 5|
| 2| 0| 1| 9| 0| 7| 5| 0| 9| 2| 9| 9| 9| 3| 1| 1| 8| 8| 5| 8| 3| 1| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
Carcinoma, Metastatic, Thyroid Gland | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + + + + + |
Leukemia Mononuclear | X X X |
Pheochromocytoma NOS | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + M + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X X X X |
Pars Distalis, Leukemia Mononuclear | X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 4| 6| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 3| 3| 5| 3| 9| 7| 3| 3| 3| 5| 2| 2| 3| 3| 3| 6| 5| 7| 5| 3| 3| 3| 3| 5|
| 2| 0| 1| 9| 0| 7| 5| 0| 9| 2| 9| 9| 9| 3| 1| 1| 8| 8| 5| 8| 3| 1| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Adenoma | |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + + + |
Adenoma | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Adenoma | X |
Leukemia Mononuclear | X X |
Endometrium, Polyp Stromal | X X |
Endometrium, Sarcoma Stromal | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X |
Mesenteric, Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + |
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + M + + + + + |
Leukemia Mononuclear | X X |
Thymoma Benign | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + |
Adenocarcinoma | X |
Adenoma | |
Fibroadenoma | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 4| 6| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 3| 3| 5| 3| 9| 7| 3| 3| 3| 5| 2| 2| 3| 3| 3| 6| 5| 7| 5| 3| 3| 3| 3| 5|
| 2| 0| 1| 9| 0| 7| 5| 0| 9| 2| 9| 9| 9| 3| 1| 1| 8| 8| 5| 8| 3| 1| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Astrocytoma Malignant | |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
Transitional Epithelium, Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| | |
DAY ON TEST | 8| 9| 3| 2| 3| 5| 5| 2| 2| 3| | |
| 3| 1| 2| 9| 3| 5| 9| 9| 2| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 49 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Hepatocellular Adenoma | | 2 |
Leukemia Mononuclear | X X X X | 17 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 14 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 49 |
Leukemia Mononuclear | X X X | 10 |
Pheochromocytoma NOS | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + M + + + M | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| | |
DAY ON TEST | 8| 9| 3| 2| 3| 5| 5| 2| 2| 3| | |
| 3| 1| 2| 9| 3| 5| 9| 9| 2| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Adenoma | X X X X X X X | 31 |
Pars Distalis, Leukemia Mononuclear | X X | 3 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
C-Cell, Adenoma | X | 2 |
C-Cell, Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + | 49 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 50 |
Adenoma | | 1 |
Leukemia Mononuclear | X | 3 |
Endometrium, Polyp Stromal | X | 4 |
Endometrium, Sarcoma Stromal | | 1 |
__________________________________________________________________________|____________|
Vagina | + | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + M + + + + + + + | 49 |
Leukemia Mononuclear | X X | 5 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 1 |
Mesenteric, Leukemia Mononuclear | X X X X | 15 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + | 47 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 17 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + | 46 |
Leukemia Mononuclear | X X X | 6 |
Thymoma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| | |
DAY ON TEST | 8| 9| 3| 2| 3| 5| 5| 2| 2| 3| | |
| 3| 1| 2| 9| 3| 5| 9| 9| 2| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 50 |
Adenocarcinoma | | 2 |
Adenoma | | 2 |
Fibroadenoma | X X X | 13 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + M + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
Astrocytoma Malignant | | 1 |
Leukemia Mononuclear | X | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Leukemia Mononuclear | X X X X | 16 |
__________________________________________________________________________|____________|
Nose | + M + + + + + + + | 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 5 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 6 |
Transitional Epithelium, Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4|
DAY ON TEST | 8| 5| 3| 3| 2| 3| 5| 3| 3| 5| 3| 5| 3| 2| 5| 2| 3| 3| 3| 3| 3| 5| 3| 5| 5|
| 1| 7| 0| 3| 9| 2| 8| 2| 3| 8| 2| 4| 0| 9| 3| 9| 3| 1| 1| 3| 0| 8| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + M + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + M + + + + + + M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X X X |
Pars Distalis, Craniopharyngioma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4|
DAY ON TEST | 8| 5| 3| 3| 2| 3| 5| 3| 3| 5| 3| 5| 3| 2| 5| 2| 3| 3| 3| 3| 3| 5| 3| 5| 5|
| 1| 7| 0| 3| 9| 2| 8| 2| 3| 8| 2| 4| 0| 9| 3| 9| 3| 1| 1| 3| 0| 8| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Adenoma | X X X X X |
C-Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + |
Adenoma | X X X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Endometrium, Polyp Stromal | X |
__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | |
Mesenteric, Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + M + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + |
Adenocarcinoma | X |
Adenoma | |
Fibroadenoma | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Subcutaneous Tissue, | |
Neurofibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4|
DAY ON TEST | 8| 5| 3| 3| 2| 3| 5| 3| 3| 5| 3| 5| 3| 2| 5| 2| 3| 3| 3| 3| 3| 5| 3| 5| 5|
| 1| 7| 0| 3| 9| 2| 8| 2| 3| 8| 2| 4| 0| 9| 3| 9| 3| 1| 1| 3| 0| 8| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Zymbal's Gland | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4|
DAY ON TEST | 2| 5| 5| 3| 5| 1| 3| 2| 3| 3| 3| 3| 5| 7| 1| 3| 3| 7| 3| 3| 2| 8| 2| 3| 5|
| 9| 3| 3| 3| 9| 7| 0| 9| 1| 7| 0| 2| 8| 6| 1| 2| 1| 9| 2| 3| 9| 1| 9| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + M + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X |
Pars Distalis, Craniopharyngioma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4|
DAY ON TEST | 2| 5| 5| 3| 5| 1| 3| 2| 3| 3| 3| 3| 5| 7| 1| 3| 3| 7| 3| 3| 2| 8| 2| 3| 5|
| 9| 3| 3| 3| 9| 7| 0| 9| 1| 7| 0| 2| 8| 6| 1| 2| 1| 9| 2| 3| 9| 1| 9| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + |
Adenoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Endometrium, Polyp Stromal | X X X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Mediastinal, Leukemia Mononuclear | X |
Mediastinal, Lymphoma Malignant | |
Histiocytic | X |
Mesenteric, Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M M + + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + |
Adenocarcinoma | |
Adenoma | X |
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + |
Subcutaneous Tissue, | |
Neurofibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4|
DAY ON TEST | 2| 5| 5| 3| 5| 1| 3| 2| 3| 3| 3| 3| 5| 7| 1| 3| 3| 7| 3| 3| 2| 8| 2| 3| 5|
| 9| 3| 3| 3| 9| 7| 0| 9| 1| 7| 0| 2| 8| 6| 1| 2| 1| 9| 2| 3| 9| 1| 9| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Zymbal's Gland | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X X |
Lymphoma Malignant Histiocytic | X |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 4| 7| 5| 4| 7| 4| 7| 4| 7| 7| | |
DAY ON TEST | 1| 3| 4| 5| 3| 5| 3| 5| 3| 3| | |
| 4| 1| 0| 8| 0| 9| 2| 9| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + | 49 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + | 49 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + | 50 |
Hepatocellular Adenoma | X | 3 |
Leukemia Mononuclear | X X | 16 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | M + + + + + + | 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 50 |
Leukemia Mononuclear | | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + M + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + M + + + | 49 |
Leukemia Mononuclear | X | 9 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + | 48 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | M + + + + + + | 49 |
Carcinoma | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 4| 7| 5| 4| 7| 4| 7| 4| 7| 7| | |
DAY ON TEST | 1| 3| 4| 5| 3| 5| 3| 5| 3| 3| | |
| 4| 1| 0| 8| 0| 9| 2| 9| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 50 |
Pars Distalis, Adenoma | X X X | 27 |
Pars Distalis, Craniopharyngioma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 50 |
C-Cell, Adenoma | | 8 |
C-Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + | 50 |
Adenoma | | 4 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Endometrium, Polyp Stromal | X | 5 |
__________________________________________________________________________|____________|
Vagina | + | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 50 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Mediastinal, Leukemia Mononuclear | | 2 |
Mediastinal, Lymphoma Malignant | | |
Histiocytic | | 1 |
Mesenteric, Leukemia Mononuclear | X X | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + | 48 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 50 |
Leukemia Mononuclear | X X | 16 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + | 46 |
Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 4| 7| 5| 4| 7| 4| 7| 4| 7| 7| | |
DAY ON TEST | 1| 3| 4| 5| 3| 5| 3| 5| 3| 3| | |
| 4| 1| 0| 8| 0| 9| 2| 9| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 50 |
Adenocarcinoma | | 1 |
Adenoma | | 1 |
Fibroadenoma | X | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + | 50 |
Subcutaneous Tissue, | | |
Neurofibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 50 |
Leukemia Mononuclear | X X | 13 |
__________________________________________________________________________|____________|
Nose | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Squamous Cell Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 50 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + | 50 |
Leukemia Mononuclear | X X | 16 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 1| 4| 4| 6| 7| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 3| 6| 9| 6| 5| 5| 4| 3| 3| 3| 4| 3| 5| 4| 3| 0| 2| 0| 5| 3| 3| 3| 3|
| 9| 3| 1| 3| 3| 5| 8| 8| 0| 0| 3| 0| 8| 2| 8| 8| 1| 6| 9| 8| 8| 0| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + M + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma NOS | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X |
Pars Distalis, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 1| 4| 4| 6| 7| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 3| 6| 9| 6| 5| 5| 4| 3| 3| 3| 4| 3| 5| 4| 3| 0| 2| 0| 5| 3| 3| 3| 3|
| 9| 3| 1| 3| 3| 5| 8| 8| 0| 0| 3| 0| 8| 2| 8| 8| 1| 6| 9| 8| 8| 0| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Leukemia Mononuclear | X |
Endometrium, Polyp Stromal | X X |
Endometrium, Sarcoma Stromal | |
__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + M + + + + + + + M + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X |
Adenoma | |
Fibroadenoma | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 1| 4| 4| 6| 7| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 3| 6| 9| 6| 5| 5| 4| 3| 3| 3| 4| 3| 5| 4| 3| 0| 2| 0| 5| 3| 3| 3| 3|
| 9| 3| 1| 3| 3| 5| 8| 8| 0| 0| 3| 0| 8| 2| 8| 8| 1| 6| 9| 8| 8| 0| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Sarcoma | |
Renal Tubule, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 5| 4| 5| 4| 7| 5| 4| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 6| 5| 3| 8| 5| 2| 3| 2| 3| 3| 3| 5| 3| 5| 6| 5| 2| 3| 2| 0| 0| 3| 3|
| 1| 9| 4| 8| 3| 4| 9| 3| 2| 1| 0| 1| 2| 9| 3| 2| 7| 9| 9| 2| 9| 6| 6| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Mesentery | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma NOS | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M M + M + + M M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X|
Pars Distalis, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 5| 4| 5| 4| 7| 5| 4| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 6| 5| 3| 8| 5| 2| 3| 2| 3| 3| 3| 5| 3| 5| 6| 5| 2| 3| 2| 0| 0| 3| 3|
| 1| 9| 4| 8| 3| 4| 9| 3| 2| 1| 0| 1| 2| 9| 3| 2| 7| 9| 9| 2| 9| 6| 6| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M M + + + + M M + + + + + + + + + M + +|
Adenoma | X X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Leukemia Mononuclear | |
Endometrium, Polyp Stromal | |
Endometrium, Sarcoma Stromal | X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + M + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + M M +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X X |
Adenoma | |
Fibroadenoma | X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 5| 4| 5| 4| 7| 5| 4| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 6| 5| 3| 8| 5| 2| 3| 2| 3| 3| 3| 5| 3| 5| 6| 5| 2| 3| 2| 0| 0| 3| 3|
| 1| 9| 4| 8| 3| 4| 9| 3| 2| 1| 0| 1| 2| 9| 3| 2| 7| 9| 9| 2| 9| 6| 6| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Mucosa, Squamous Cell Carcinoma | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Sarcoma | X |
Renal Tubule, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 5| 5| 3| 3| 2| 3| 3| 2| 3| 3| | |
| 9| 4| 3| 2| 9| 0| 3| 9| 3| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X | 10 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
Squamous Cell Carcinoma | X | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Tooth | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 3 |
Pheochromocytoma NOS | X | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 5| 5| 3| 3| 2| 3| 3| 2| 3| 3| | |
| 9| 4| 3| 2| 9| 0| 3| 9| 3| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + + + + | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 50 |
Pars Distalis, Adenoma | X X X X X X | 31 |
Pars Distalis, Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
C-Cell, Adenoma | X | 3 |
C-Cell, Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + | 44 |
Adenoma | | 3 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 50 |
Granulosa Cell Tumor Malignant | | 2 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 50 |
Adenocarcinoma | | 1 |
Leukemia Mononuclear | X | 2 |
Endometrium, Polyp Stromal | | 2 |
Endometrium, Sarcoma Stromal | | 1 |
__________________________________________________________________________|____________|
Vagina | | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 50 |
Mesenteric, Leukemia Mononuclear | X X X | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + | 42 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + | 46 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 5| 5| 3| 3| 2| 3| 3| 2| 3| 3| | |
| 9| 4| 3| 2| 9| 0| 3| 9| 3| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Adenocarcinoma | X | 6 |
Adenoma | X | 1 |
Fibroadenoma | X | 7 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Keratoacanthoma | | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Lipoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 50 |
Mucosa, Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 5 |
Sarcoma | | 1 |
Renal Tubule, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 5| 6| 7| 7| 6| 7| 4| 7| 4| 7|
DAY ON TEST | 5| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 3| 3| 8| 5| 3| 3| 2| 3| 5| 3| 7| 2|
| 9| 0| 9| 0| 3| 0| 2| 2| 3| 5| 3| 1| 1| 8| 1| 9| 2| 3| 1| 5| 0| 9| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + M + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Mucinous | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Acinus, Adenoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma Adenosquamous, Metastatic, | |
Lung | |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 5| 6| 7| 7| 6| 7| 4| 7| 4| 7|
DAY ON TEST | 5| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 3| 3| 8| 5| 3| 3| 2| 3| 5| 3| 7| 2|
| 9| 0| 9| 0| 3| 0| 2| 2| 3| 5| 3| 1| 1| 8| 1| 9| 2| 3| 1| 5| 0| 9| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma NOS | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M M + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X|
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X X X X |
Follicle, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X |
Serosa, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma Adenosquamous, Metastatic, | |
Lung | |
Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X |
Mesenteric, Leukemia Mononuclear | X X X |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + M + M M + + M + + M +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 5| 6| 7| 7| 6| 7| 4| 7| 4| 7|
DAY ON TEST | 5| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 3| 3| 8| 5| 3| 3| 2| 3| 5| 3| 7| 2|
| 9| 0| 9| 0| 3| 0| 2| 2| 3| 5| 3| 1| 1| 8| 1| 9| 2| 3| 1| 5| 0| 9| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Thymus | + + M + M + + + + + + + + + + M + + + + + + +|
Carcinoma Adenosquamous, Metastatic, | |
Lung | |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | X |
Thoracic, Subcutaneous Tissue, | |
Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma Adenosquamous | |
Leukemia Monocytic | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma Adenosquamous, Metastatic, | |
Lung | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Sarcoma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 5| 6| 7| 7| 6| 7| 4| 7| 4| 7|
DAY ON TEST | 5| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 3| 3| 8| 5| 3| 3| 2| 3| 5| 3| 7| 2|
| 9| 0| 9| 0| 3| 0| 2| 2| 3| 5| 3| 1| 1| 8| 1| 9| 2| 3| 1| 5| 0| 9| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Leukemia Monocytic | |
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Lymphocytic | X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 4| 6| 4| 7| 7| 4| 6| 6| 7| 6| 4| 6| 7| 6| 7| 4| 6| 7| 7| 4| 7| 6| 6| 6| 4|
DAY ON TEST | 5| 3| 5| 3| 3| 7| 1| 6| 3| 7| 5| 2| 3| 7| 2| 5| 2| 3| 3| 5| 3| 1| 0| 7| 5|
| 9| 1| 8| 2| 2| 2| 4| 3| 2| 3| 8| 5| 2| 2| 9| 9| 2| 1| 3| 8| 0| 8| 2| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + |
Adenocarcinoma, Mucinous | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Hepatocellular Adenoma | X X |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Acinus, Adenoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Carcinoma Adenosquamous, Metastatic, | |
Lung | X |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 4| 6| 4| 7| 7| 4| 6| 6| 7| 6| 4| 6| 7| 6| 7| 4| 6| 7| 7| 4| 7| 6| 6| 6| 4|
DAY ON TEST | 5| 3| 5| 3| 3| 7| 1| 6| 3| 7| 5| 2| 3| 7| 2| 5| 2| 3| 3| 5| 3| 1| 0| 7| 5|
| 9| 1| 8| 2| 2| 2| 4| 3| 2| 3| 8| 5| 2| 2| 9| 9| 2| 1| 3| 8| 0| 8| 2| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma NOS | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + |
Adenoma | X X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M + + M + + + + + + M + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X X X X |
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
C-Cell, Adenoma | X |
Follicle, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + |
Carcinoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Bilateral, Interstitial Cell, Adenoma| X X X X |
Interstitial Cell, Adenoma | X X X X X X X X |
Serosa, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + |
Carcinoma Adenosquamous, Metastatic, | |
Lung | X |
Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X X |
Mesenteric, Leukemia Mononuclear | X X X X X X |
Mesenteric, Lymphoma Malignant | |
Lymphocytic | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + M + + M + M + + + M + + + M M + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 4| 6| 4| 7| 7| 4| 6| 6| 7| 6| 4| 6| 7| 6| 7| 4| 6| 7| 7| 4| 7| 6| 6| 6| 4|
DAY ON TEST | 5| 3| 5| 3| 3| 7| 1| 6| 3| 7| 5| 2| 3| 7| 2| 5| 2| 3| 3| 5| 3| 1| 0| 7| 5|
| 9| 1| 8| 2| 2| 2| 4| 3| 2| 3| 8| 5| 2| 2| 9| 9| 2| 1| 3| 8| 0| 8| 2| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + M + + M + + + + + + + + |
Carcinoma Adenosquamous, Metastatic, | |
Lung | X |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + |
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
Subcutaneous Tissue, Fibroma | |
Thoracic, Subcutaneous Tissue, | |
Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Carcinoma Adenosquamous | X |
Leukemia Monocytic | X |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
Carcinoma Adenosquamous, Metastatic, | |
Lung | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 4| 6| 4| 7| 7| 4| 6| 6| 7| 6| 4| 6| 7| 6| 7| 4| 6| 7| 7| 4| 7| 6| 6| 6| 4|
DAY ON TEST | 5| 3| 5| 3| 3| 7| 1| 6| 3| 7| 5| 2| 3| 7| 2| 5| 2| 3| 3| 5| 3| 1| 0| 7| 5|
| 9| 1| 8| 2| 2| 2| 4| 3| 2| 3| 8| 5| 2| 2| 9| 9| 2| 1| 3| 8| 0| 8| 2| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Leukemia Monocytic | X |
Leukemia Mononuclear | X X X X X X X X |
Lymphoma Malignant Lymphocytic | |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2| | |
| 9| 7| 6| 8| 9| 1| 9| 1| 0| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 49 |
Leukemia Mononuclear | X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 50 |
Adenocarcinoma, Mucinous | | 1 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Hepatocellular Adenoma | | 4 |
Leukemia Mononuclear | X X X X X | 16 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
Acinus, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Carcinoma Adenosquamous, Metastatic, | | |
Lung | | 1 |
Leukemia Mononuclear | X X | 9 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2| | |
| 9| 7| 6| 8| 9| 1| 9| 1| 0| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 14 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 49 |
Leukemia Mononuclear | X X X | 11 |
Pheochromocytoma NOS | X X | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
Adenoma | | 2 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 49 |
Pars Distalis, Adenoma | X X X | 22 |
Pars Distalis, Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
C-Cell, Adenoma | | 5 |
Follicle, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 50 |
Carcinoma | X | 1 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
Bilateral, Interstitial Cell, Adenoma| X X X | 23 |
Interstitial Cell, Adenoma | X X | 13 |
Serosa, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 4 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 50 |
Leukemia Mononuclear | X X X | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
Carcinoma Adenosquamous, Metastatic, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2| | |
| 9| 7| 6| 8| 9| 1| 9| 1| 0| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lung | | 1 |
Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 4 |
Mesenteric, Leukemia Mononuclear | X X X X X | 14 |
Mesenteric, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Renal, Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + | 36 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X X | 17 |
__________________________________________________________________________|____________|
Thymus | + M + + + + + + | 44 |
Carcinoma Adenosquamous, Metastatic, | | |
Lung | | 1 |
Leukemia Mononuclear | X X | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 50 |
Fibroadenoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 50 |
Subcutaneous Tissue, Fibroma | X | 2 |
Thoracic, Subcutaneous Tissue, | | |
Fibroma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Carcinoma Adenosquamous | | 1 |
Leukemia Monocytic | | 1 |
Leukemia Mononuclear | X X X X X | 16 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
Carcinoma Adenosquamous, Metastatic, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2| | |
| 9| 7| 6| 8| 9| 1| 9| 1| 0| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lung | | 1 |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 5 |
Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 50 |
Leukemia Monocytic | | 1 |
Leukemia Mononuclear | X X X X X | 17 |
Lymphoma Malignant Lymphocytic | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 6| 2| 6| 7| 6| 7| 4| 7| 6| 7| 7| 4| 4| 7| 6| 6| 7| 7| 5| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 8| 8| 2| 3| 8| 3| 5| 3| 8| 3| 2| 5| 7| 3| 2| 1| 3| 3| 7| 9| 7| 3| 7| 1| 1|
| 1| 3| 5| 1| 9| 0| 8| 2| 8| 3| 9| 9| 8| 0| 4| 8| 3| 1| 2| 8| 0| 2| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X |
Histiocytic Sarcoma, Metastatic | X |
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Fibrosarcoma, Metastatic, | |
Skin | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 6| 2| 6| 7| 6| 7| 4| 7| 6| 7| 7| 4| 4| 7| 6| 6| 7| 7| 5| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 8| 8| 2| 3| 8| 3| 5| 3| 8| 3| 2| 5| 7| 3| 2| 1| 3| 3| 7| 9| 7| 3| 7| 1| 1|
| 1| 3| 5| 1| 9| 0| 8| 2| 8| 3| 9| 9| 8| 0| 4| 8| 3| 1| 2| 8| 0| 2| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Malignant | X |
Pheochromocytoma NOS | X X |
Bilateral, Pheochromocytoma NOS | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X|
Pars Distalis, Leukemia Mononuclear | X |
Pars Intermedia, Leukemia Mononuclear| X |
Pars Nervosa, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
Follicle, Adenoma | X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Seminal Vesicle | + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Iliac, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X X |
Mesenteric, Leukemia Mononuclear | X X X X X X X X X |
Renal, Carcinoma, Metastatic, Kidney | X |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 6| 2| 6| 7| 6| 7| 4| 7| 6| 7| 7| 4| 4| 7| 6| 6| 7| 7| 5| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 8| 8| 2| 3| 8| 3| 5| 3| 8| 3| 2| 5| 7| 3| 2| 1| 3| 3| 7| 9| 7| 3| 7| 1| 1|
| 1| 3| 5| 1| 9| 0| 8| 2| 8| 3| 9| 9| 8| 0| 4| 8| 3| 1| 2| 8| 0| 2| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + M + + + M + M + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic | X |
Keratoacanthoma | X |
Subcutaneous Tissue, Fibrosarcoma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Cerebrum, Astrocytoma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Kidney | X |
Fibrosarcoma, Metastatic, Skin | X |
Histiocytic Sarcoma, Metastatic | X |
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + + |
Carcinoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic | X |
Leukemia Mononuclear | X X X X |
Capsule, Fibrosarcoma, Metastatic, | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 6| 2| 6| 7| 6| 7| 4| 7| 6| 7| 7| 4| 4| 7| 6| 6| 7| 7| 5| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 8| 8| 2| 3| 8| 3| 5| 3| 8| 3| 2| 5| 7| 3| 2| 1| 3| 3| 7| 9| 7| 3| 7| 1| 1|
| 1| 3| 5| 1| 9| 0| 8| 2| 8| 3| 9| 9| 8| 0| 4| 8| 3| 1| 2| 8| 0| 2| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Skin | X |
Renal Tubule, Adenoma | X |
Transitional Epithelium, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 4| 0| 6|
DAY ON TEST | 2| 7| 3| 3| 3| 2| 2| 9| 3| 9| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 5| 2| 8|
| 9| 0| 3| 2| 3| 9| 9| 8| 3| 8| 1| 9| 1| 0| 1| 2| 8| 2| 3| 9| 0| 1| 8| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
Capsule, Fibrosarcoma, Metastatic, | |
Skin | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 4| 0| 6|
DAY ON TEST | 2| 7| 3| 3| 3| 2| 2| 9| 3| 9| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 5| 2| 8|
| 9| 0| 3| 2| 3| 9| 9| 8| 3| 8| 1| 9| 1| 0| 1| 2| 8| 2| 3| 9| 0| 1| 8| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Malignant | |
Pheochromocytoma NOS | X X X |
Bilateral, Pheochromocytoma NOS | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + M + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X|
Pars Distalis, Leukemia Mononuclear | X X |
Pars Intermedia, Leukemia Mononuclear| |
Pars Nervosa, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X X X X X X|
C-Cell, Carcinoma | |
Follicle, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Iliac, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X X |
Mesenteric, Leukemia Mononuclear | X X X X X X X X|
Renal, Carcinoma, Metastatic, Kidney | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 4| 0| 6|
DAY ON TEST | 2| 7| 3| 3| 3| 2| 2| 9| 3| 9| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 5| 2| 8|
| 9| 0| 3| 2| 3| 9| 9| 8| 3| 8| 1| 9| 1| 0| 1| 2| 8| 2| 3| 9| 0| 1| 8| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + M + + +|
Carcinoma, Metastatic, Kidney | |
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic | |
Keratoacanthoma | |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
Cerebrum, Astrocytoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Kidney | |
Fibrosarcoma, Metastatic, Skin | |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X X X X|
Capsule, Fibrosarcoma, Metastatic, | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 4| 0| 6|
DAY ON TEST | 2| 7| 3| 3| 3| 2| 2| 9| 3| 9| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 5| 2| 8|
| 9| 0| 3| 2| 3| 9| 9| 8| 3| 8| 1| 9| 1| 0| 1| 2| 8| 2| 3| 9| 0| 1| 8| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Skin | |
Renal Tubule, Adenoma | |
Transitional Epithelium, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 4| 4| 7| 4| 7| 7| 7| | |
DAY ON TEST | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3| | |
| 3| 9| 4| 8| 9| 3| 8| 0| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 50 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | | 2 |
Histiocytic Sarcoma, Metastatic | | 1 |
Leukemia Mononuclear | X X X | 25 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 50 |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 50 |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 50 |
Leukemia Mononuclear | X X | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + | 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + | 50 |
Leukemia Mononuclear | X X X | 17 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 50 |
Capsule, Fibrosarcoma, Metastatic, | | |
Skin | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 4| 4| 7| 4| 7| 7| 7| | |
DAY ON TEST | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3| | |
| 3| 9| 4| 8| 9| 3| 8| 0| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 50 |
Adenoma | | 1 |
Leukemia Mononuclear | X X | 16 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 50 |
Leukemia Mononuclear | X X | 16 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma NOS | X X | 7 |
Bilateral, Pheochromocytoma NOS | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 50 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 50 |
Pars Distalis, Adenoma | X X | 24 |
Pars Distalis, Leukemia Mononuclear | X X | 5 |
Pars Intermedia, Leukemia Mononuclear| | 1 |
Pars Nervosa, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
C-Cell, Adenoma | | 7 |
C-Cell, Carcinoma | | 1 |
Follicle, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 50 |
Adenoma | X | 1 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 5 |
__________________________________________________________________________|____________|
Testes | + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
Bilateral, Interstitial Cell, Adenoma| X X X | 27 |
Interstitial Cell, Adenoma | X X | 9 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 4| 4| 7| 4| 7| 7| 7| | |
DAY ON TEST | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3| | |
| 3| 9| 4| 8| 9| 3| 8| 0| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 50 |
Leukemia Mononuclear | X X | 15 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 50 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Iliac, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 5 |
Mesenteric, Leukemia Mononuclear | X X X | 20 |
Renal, Carcinoma, Metastatic, Kidney | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 45 |
Leukemia Mononuclear | X X | 11 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 50 |
Hemangiosarcoma | | 1 |
Leukemia Mononuclear | X X X X | 25 |
__________________________________________________________________________|____________|
Thymus | + + M + + M | 46 |
Carcinoma, Metastatic, Kidney | | 1 |
Leukemia Mononuclear | X X | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + | 48 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 50 |
Histiocytic Sarcoma, Metastatic | | 1 |
Keratoacanthoma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 50 |
Leukemia Mononuclear | X X | 7 |
Cerebrum, Astrocytoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 50 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Carcinoma, Metastatic, Kidney | | 1 |
Fibrosarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 4| 4| 7| 4| 7| 7| 7| | |
DAY ON TEST | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3| | |
| 3| 9| 4| 8| 9| 3| 8| 0| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Histiocytic Sarcoma, Metastatic | | 1 |
Leukemia Mononuclear | X X | 22 |
__________________________________________________________________________|____________|
Nose | + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 50 |
Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 50 |
Histiocytic Sarcoma, Metastatic | | 1 |
Leukemia Mononuclear | X X | 10 |
Capsule, Fibrosarcoma, Metastatic, | | |
Skin | | 1 |
Renal Tubule, Adenoma | | 1 |
Transitional Epithelium, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 50 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Leukemia Mononuclear | X X | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 26 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 5| 6| 4| 6|
DAY ON TEST | 3| 3| 9| 3| 5| 2| 4| 4| 9| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 2| 5| 9| 7| 5| 5|
| 3| 1| 1| 2| 8| 2| 0| 3| 6| 2| 2| 2| 0| 9| 6| 1| 6| 1| 1| 6| 2| 7| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
Serosa, Mesothelioma Malignant | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Serosa, Mesothelioma Malignant | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Mesothelioma Malignant | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Pheochromocytoma NOS | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 5| 6| 4| 6|
DAY ON TEST | 3| 3| 9| 3| 5| 2| 4| 4| 9| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 2| 5| 9| 7| 5| 5|
| 3| 1| 1| 2| 8| 2| 0| 3| 6| 2| 2| 2| 0| 9| 6| 1| 6| 1| 1| 6| 2| 7| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X|
Pars Distalis, Carcinoma | |
Pars Distalis, Leukemia Monocytic | |
Pars Distalis, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X |
Serosa, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | |
Mesenteric, Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M M M + + + + + M + M + + + + M + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
Lymphoma Malignant | |
Capsule, Mesothelioma Malignant | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + +|
Leukemia Mononuclear | X X |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 5| 6| 4| 6|
DAY ON TEST | 3| 3| 9| 3| 5| 2| 4| 4| 9| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 2| 5| 9| 7| 5| 5|
| 3| 1| 1| 2| 8| 2| 0| 3| 6| 2| 2| 2| 0| 9| 6| 1| 6| 1| 1| 6| 2| 7| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Fibrosarcoma | |
Tail, Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma Adenosquamous | X |
Fibrous Histiocytoma, Metastatic, | |
Skin | |
Leukemia Mononuclear | X X X X X X X X|
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Nose | + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Capsule, Mesothelioma Malignant | |
Renal Tubule, Adenoma | X X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Serosa, Mesothelioma Malignant | |
Transitional Epithelium, Papilloma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Monocytic | |
Leukemia Mononuclear | X X X X X X X X X X|
Lymphoma Malignant | |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 4| 4| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 5| 7| 4| 4| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 2| 5| 3| 9| 3| 2| 0| 3| 2| 5| 5| 3| 6| 3| 0| 5| 1| 5| 7| 3| 2| 3|
| 8| 9| 8| 6| 8| 2| 7| 0| 9| 4| 3| 9| 9| 9| 3| 0| 2| 8| 6| 5| 9| 8| 3| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Serosa, Mesothelioma Malignant | X |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Serosa, Mesothelioma Malignant | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
Capsule, Mesothelioma Malignant | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma NOS | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + M + + + M + + M + + +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 4| 4| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 5| 7| 4| 4| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 2| 5| 3| 9| 3| 2| 0| 3| 2| 5| 5| 3| 6| 3| 0| 5| 1| 5| 7| 3| 2| 3|
| 8| 9| 8| 6| 8| 2| 7| 0| 9| 4| 3| 9| 9| 9| 3| 0| 2| 8| 6| 5| 9| 8| 3| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X |
Pars Distalis, Carcinoma | |
Pars Distalis, Leukemia Monocytic | X |
Pars Distalis, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X |
Serosa, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Mesenteric, Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + M M M + + + + + + M + + M + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Lymphoma Malignant | X |
Capsule, Mesothelioma Malignant | X |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + M + + + +|
Leukemia Mononuclear | X |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
_____________________________________________________________________________________________________________________
| 4| 4| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 5| 7| 4| 4| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 2| 5| 3| 9| 3| 2| 0| 3| 2| 5| 5| 3| 6| 3| 0| 5| 1| 5| 7| 3| 2| 3|
| 8| 9| 8| 6| 8| 2| 7| 0| 9| 4| 3| 9| 9| 9| 3| 0| 2| 8| 6| 5| 9| 8| 3| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Fibrosarcoma | X |
Tail, Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Carcinoma Adenosquamous | |
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
Leukemia Mononuclear | X X X X |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Capsule, Mesothelioma Malignant | X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Serosa, Mesothelioma Malignant | X |
Transitional Epithelium, Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + +|
Leukemia Monocytic | X |
Leukemia Mononuclear | X X X X X |
Lymphoma Malignant | X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 2| 6| 7| 6| 4| | |
DAY ON TEST | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5| | |
| 5| 0| 1| 9| 8| 5| 1| 9| 1| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 49 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 19 |
Serosa, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
Serosa, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 49 |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 7 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
Capsule, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 2| 6| 7| 6| 4| | |
DAY ON TEST | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5| | |
| 5| 0| 1| 9| 8| 5| 1| 9| 1| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma NOS | | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
Adenoma | | 2 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 50 |
Pars Distalis, Adenoma | X X X | 18 |
Pars Distalis, Carcinoma | X | 1 |
Pars Distalis, Leukemia Monocytic | | 1 |
Pars Distalis, Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 50 |
C-Cell, Adenoma | | 8 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 50 |
Bilateral, Interstitial Cell, Adenoma| X X X | 30 |
Interstitial Cell, Adenoma | X X | 10 |
Serosa, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 4 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 12 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Mediastinal, Leukemia Mononuclear | | 1 |
Mesenteric, Leukemia Mononuclear | X X X | 17 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M M + + + | 37 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 19 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 2| 6| 7| 6| 4| | |
DAY ON TEST | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5| | |
| 5| 0| 1| 9| 8| 5| 1| 9| 1| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Capsule, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + M + + | 46 |
Leukemia Mononuclear | X | 4 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 50 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Tail, Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Fibrosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Carcinoma Adenosquamous | | 1 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
Leukemia Mononuclear | X X | 14 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05701-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:05:35
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 2| 6| 7| 6| 4| | |
DAY ON TEST | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5| | |
| 5| 0| 1| 9| 8| 5| 1| 9| 1| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Leukemia Mononuclear | | 4 |
Capsule, Mesothelioma Malignant | | 1 |
Renal Tubule, Adenoma | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
Serosa, Mesothelioma Malignant | | 1 |
Transitional Epithelium, Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 50 |
Leukemia Monocytic | | 1 |
Leukemia Mononuclear | X X X X | 19 |
Lymphoma Malignant | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
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