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TR 371 Rat Pathology Tables

NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35




       Facility:  International Research and Development Corp.

       Chemical CAS #:  108883

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 5| 2| 3| 2| 3| 5| 1| 0| 3| 5| 2| 4| 1| 3| 2| 3| 3| 3| 3|             
                                           | 0| 2| 8| 3| 0| 2| 9| 9| 0| 6| 2| 8| 0| 8| 1| 8| 9| 4| 9| 8| 9| 3| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  M  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                     X                                    |             
      Leukemia Mononuclear                 |    X                 X     X                    X                 X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X     X                    X                 X     X|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                          X                 X     X|             
      Pheochromocytoma NOS                 |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X              X     X  X  X  X     X  X  X           X     X  X  X  X   |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 5| 2| 3| 2| 3| 5| 1| 0| 3| 5| 2| 4| 1| 3| 2| 3| 3| 3| 3|             
                                           | 0| 2| 8| 3| 0| 2| 9| 9| 0| 6| 2| 8| 0| 8| 1| 8| 9| 4| 9| 8| 9| 3| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |          X                                                               |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Endometrium, Polyp Stromal           |                                                                   X      |             
      Endometrium, Sarcoma Stromal         |             X                                                            |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                    +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Mesenteric, Leukemia Mononuclear     |                      X     X                    X        X        X     X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +     +  M  M  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |                                                          X        X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                 X     X                    X        X        X     X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +     +  +  +  +     +  M  +     +  +  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
      Thymoma Benign                       |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                   X      |             
      Adenoma                              | X                                   X                                    |             
      Fibroadenoma                         | X  X                          X     X     X                 X  X        X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 5| 3| 3| 3| 5| 2| 3| 2| 3| 5| 1| 0| 3| 5| 2| 4| 1| 3| 2| 3| 3| 3| 3|             
                                           | 0| 2| 8| 3| 0| 2| 9| 9| 0| 6| 2| 8| 0| 8| 1| 8| 9| 4| 9| 8| 9| 3| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                               X                                          |             
      Leukemia Mononuclear                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |                      X     X                    X        X        X     X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                          +               |             
      Carcinoma                            |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Transitional Epithelium, Papilloma   |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +  +  +     +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                 X     X                    X        X        X     X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 4| 6| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 5| 3| 9| 7| 3| 3| 3| 5| 2| 2| 3| 3| 3| 6| 5| 7| 5| 3| 3| 3| 3| 5|             
                                           | 2| 0| 1| 9| 0| 7| 5| 0| 9| 2| 9| 9| 9| 3| 1| 1| 8| 8| 5| 8| 3| 1| 1| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Hepatocellular Adenoma               |                                                                X         |             
      Leukemia Mononuclear                 |             X  X  X     X           X  X  X                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Leukemia Mononuclear                 |                X  X     X                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X     X           X  X  X                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +     +  +  +  +  +  M     +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X     X                 X                              |             
      Pheochromocytoma NOS                 |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +     +  +  +  +  +  +     +  +  +  +  +  +     M     +  +  +  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Pars Distalis, Adenoma               |                X     X              X  X  X  X  X     X           X  X   |             
      Pars Distalis, Leukemia Mononuclear  |                   X                                                      |             
      Pars Intermedia, Adenoma             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 4| 6| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 5| 3| 9| 7| 3| 3| 3| 5| 2| 2| 3| 3| 3| 6| 5| 7| 5| 3| 3| 3| 3| 5|             
                                           | 2| 0| 1| 9| 0| 7| 5| 0| 9| 2| 9| 9| 9| 3| 1| 1| 8| 8| 5| 8| 3| 1| 1| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +     +  +  +  +  +  +     +  M  +  +  +  +     +     +  +  +  +   |             
      Adenoma                              |    X                                   X                                 |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X     X                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Adenoma                              |                                        X                                 |             
      Leukemia Mononuclear                 |                   X     X                                                |             
      Endometrium, Polyp Stromal           |                   X                                               X      |             
      Endometrium, Sarcoma Stromal         |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Leukemia Mononuclear                 |                X  X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                X                                                         |             
      Mesenteric, Leukemia Mononuclear     |             X  X  X     X                 X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  M  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Leukemia Mononuclear                 |             X  X  X     X              X  X                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  M  +  +  +     +  +  +  +  +  M     +     +  +  +  +   |             
      Leukemia Mononuclear                 |                X        X                                                |             
      Thymoma Benign                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Adenocarcinoma                       |                                     X                                    |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |                                     X                             X      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 4| 6| 4| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 4| 3| 3| 5| 3| 9| 7| 3| 3| 3| 5| 2| 2| 3| 3| 3| 6| 5| 7| 5| 3| 3| 3| 3| 5|             
                                           | 2| 0| 1| 9| 0| 7| 5| 0| 9| 2| 9| 9| 9| 3| 1| 1| 8| 8| 5| 8| 3| 1| 1| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Astrocytoma Malignant                |                                                                          |             
      Leukemia Mononuclear                 |                   X     X                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |             X     X     X           X  X  X                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +  +     +                       +                        |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Leukemia Mononuclear                 |                X  X     X              X                                 |             
      Transitional Epithelium, Papilloma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +   |             
      Leukemia Mononuclear                 |             X  X  X     X           X  X  X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 6| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 9| 3| 2| 3| 5| 5| 2| 2| 3|                                            |            |
                                           | 3| 1| 2| 9| 3| 5| 9| 9| 2| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     A      |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +     +  +  +                                             |  49        |
      Carcinoma, Metastatic, Thyroid Gland |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +     +  +  +                                             |  50        |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Leukemia Mononuclear                 |    X           X        X  X                                             |         17 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |    X                                                                     |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |    X                       X                                             |          3 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |    X                                                                     |          5 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |    X           X        X  X                                             |         14 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +  +  +                                             |  49        |
      Leukemia Mononuclear                 |    X                    X  X                                             |         10 |
      Pheochromocytoma NOS                 |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  +  M  +     +  +  M                                             |  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +     +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 6| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 9| 3| 2| 3| 5| 5| 2| 2| 3|                                            |            |
                                           | 3| 1| 2| 9| 3| 5| 9| 9| 2| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     A      |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma               | X     X  X     X     X  X  X                                             |         31 |
      Pars Distalis, Leukemia Mononuclear  |                         X  X                                             |          3 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                X                                                         |          1 |
      C-Cell, Adenoma                      |                X                                                         |          2 |
      C-Cell, Carcinoma                    |                            X                                             |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +     +  +  +                                             |  49        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                            X                                             |          4 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +     +  +  +                                             |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                            X                                             |          3 |
      Endometrium, Polyp Stromal           |             X                                                            |          4 |
      Endometrium, Sarcoma Stromal         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                            +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  M  +  +  +  +     +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                         X  X                                             |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
      Mesenteric, Leukemia Mononuclear     |    X           X        X  X                                             |         15 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +     +  +  +                                             |  47        |
      Carcinoma, Metastatic, Thyroid Gland |                            X                                             |          1 |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |    X           X        X  X                                             |         17 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +     +  +  +                                             |  46        |
      Leukemia Mononuclear                 |    X                    X  X                                             |          6 |
      Thymoma Benign                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 6| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 9| 3| 2| 3| 5| 5| 2| 2| 3|                                            |            |
                                           | 3| 1| 2| 9| 3| 5| 9| 9| 2| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     A      |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +     +  +  +                                             |  50        |
      Adenocarcinoma                       |                                                                          |          2 |
      Adenoma                              |                                                                          |          2 |
      Fibroadenoma                         |       X        X        X                                                |         13 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +     +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  M  +  +  +  +     +  +  +                                             |  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +     +  +  +                                             |  50        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Leukemia Mononuclear                 |                            X                                             |          4 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +     +  +  +                                             |  50        |
      Carcinoma, Metastatic, Thyroid Gland |                            X                                             |          1 |
      Leukemia Mononuclear                 |    X           X        X  X                                             |         16 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  M  +  +  +  +     +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +     +  +  +                                             |  50        |
      Carcinoma, Metastatic, Thyroid Gland |                            X                                             |          1 |
      Leukemia Mononuclear                 |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   5        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                X           X                                             |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                         X  X                                             |          6 |
      Transitional Epithelium, Papilloma   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |    X           X        X  X                                             |         18 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4|             
                             DAY ON TEST   | 8| 5| 3| 3| 2| 3| 5| 3| 3| 5| 3| 5| 3| 2| 5| 2| 3| 3| 3| 3| 3| 5| 3| 5| 5|             
                                           | 1| 7| 0| 3| 9| 2| 8| 2| 3| 8| 2| 4| 0| 9| 3| 9| 3| 1| 1| 3| 0| 8| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Hepatocellular Adenoma               |                X                                                         |             
      Leukemia Mononuclear                 | X              X              X                                   X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 | X                             X                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 | X                             X                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  M  +      |             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +     +  +     +  +  +  M  +  +  +  +  +  +  M  +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Pars Distalis, Adenoma               |    X  X     X  X                       X  X                 X  X  X      |             
      Pars Distalis, Craniopharyngioma     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4|             
                             DAY ON TEST   | 8| 5| 3| 3| 2| 3| 5| 3| 3| 5| 3| 5| 3| 2| 5| 2| 3| 3| 3| 3| 3| 5| 3| 5| 5|             
                                           | 1| 7| 0| 3| 9| 2| 8| 2| 3| 8| 2| 4| 0| 9| 3| 9| 3| 1| 1| 3| 0| 8| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |                                        X  X  X        X        X         |             
      C-Cell, Carcinoma                    |                                                          X  X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Adenoma                              |                X                 X                 X  X                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 | X                                                                        |             
      Endometrium, Polyp Stromal           |                                           X                              |             
                                            __________________________________________________________________________|             
   Vagina                                  |       +                                                        +         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
      Mediastinal, Leukemia Mononuclear    | X                                                                        |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mesenteric, Leukemia Mononuclear     | X              X              X                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 | X                             X                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 | X              X              X                                   X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  M  +  M  +  +  +      |             
      Leukemia Mononuclear                 |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Adenocarcinoma                       |                X                                                         |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |                                                 X        X               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4|             
                             DAY ON TEST   | 8| 5| 3| 3| 2| 3| 5| 3| 3| 5| 3| 5| 3| 2| 5| 2| 3| 3| 3| 3| 3| 5| 3| 5| 5|             
                                           | 1| 7| 0| 3| 9| 2| 8| 2| 3| 8| 2| 4| 0| 9| 3| 9| 3| 1| 1| 3| 0| 8| 1| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 | X              X              X                                   X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +        +                                                         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +      |             
      Leukemia Mononuclear                 | X              X              X                                   X      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4|             
                             DAY ON TEST   | 2| 5| 5| 3| 5| 1| 3| 2| 3| 3| 3| 3| 5| 7| 1| 3| 3| 7| 3| 3| 2| 8| 2| 3| 5|             
                                           | 9| 3| 3| 3| 9| 7| 0| 9| 1| 7| 0| 2| 8| 6| 1| 2| 1| 9| 2| 3| 9| 1| 9| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                        X                          X      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                        X                          X      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Hepatocellular Adenoma               |                         X                                                |             
      Leukemia Mononuclear                 |    X           X     X                 X  X  X  X           X     X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                        X  X                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |    X                                   X  X                 X     X  X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |    X                                   X  X                 X     X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Carcinoma                            |                               X                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  +  +  +  +  +  +     M  +  M  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Pars Distalis, Adenoma               |          X     X     X     X  X  X     X        X  X  X  X  X  X  X  X   |             
      Pars Distalis, Craniopharyngioma     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4|             
                             DAY ON TEST   | 2| 5| 5| 3| 5| 1| 3| 2| 3| 3| 3| 3| 5| 7| 1| 3| 3| 7| 3| 3| 2| 8| 2| 3| 5|             
                                           | 9| 3| 3| 3| 9| 7| 0| 9| 1| 7| 0| 2| 8| 6| 1| 2| 1| 9| 2| 3| 9| 1| 9| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |       X                                         X           X            |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                        X  X                       X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Endometrium, Polyp Stromal           |                            X                             X  X            |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                        X                          X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |    X                                                        X            |             
      Mediastinal, Leukemia Mononuclear    |    X                                                                     |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                         X                                                |             
      Mesenteric, Leukemia Mononuclear     |                X                       X  X  X  X           X     X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                                             X     X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |    X           X     X                 X  X  X  X           X     X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  M  M  +  +  +   |             
      Leukemia Mononuclear                 |                X                             X                    X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                X                                                         |             
      Fibroadenoma                         |                                                             X            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4|             
                             DAY ON TEST   | 2| 5| 5| 3| 5| 1| 3| 2| 3| 3| 3| 3| 5| 7| 1| 3| 3| 7| 3| 3| 2| 8| 2| 3| 5|             
                                           | 9| 3| 3| 3| 9| 7| 0| 9| 1| 7| 0| 2| 8| 6| 1| 2| 1| 9| 2| 3| 9| 1| 9| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |    X                                   X                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |    X                                   X  X  X              X     X  X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                      +                  |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                           X  X                    X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |                                           X                       X      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +   |             
      Leukemia Mononuclear                 |    X           X     X                 X  X  X  X           X     X  X   |             
      Lymphoma Malignant Histiocytic       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 5| 4| 7| 4| 7| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 3| 4| 5| 3| 5| 3| 5| 3| 3|                                            |            |
                                           | 4| 1| 0| 8| 0| 9| 2| 9| 3| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     A      |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +     +     +     +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +     +     +     +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +     +     +     +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +     +     +     +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +     +     +     +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +     +     +     +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +     +     +  +                                             |  50        |
      Hepatocellular Adenoma               |             X                                                            |          3 |
      Leukemia Mononuclear                 |       X     X                                                            |         16 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | M  +  +     +     +     +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +     +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     M     +     +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     M     +     +  +                                             |  49        |
      Leukemia Mononuclear                 |       X                                                                  |          9 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     M     +     +  +                                             |  48        |
      Leukemia Mononuclear                 |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | M  +  +     +     +     +  +                                             |  49        |
      Carcinoma                            |             X                                                            |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 5| 4| 7| 4| 7| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 3| 4| 5| 3| 5| 3| 5| 3| 3|                                            |            |
                                           | 4| 1| 0| 8| 0| 9| 2| 9| 3| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     A      |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +     +     M     +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +     +     +  +                                             |  50        |
      Pars Distalis, Adenoma               |    X                    X  X                                             |         27 |
      Pars Distalis, Craniopharyngioma     |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +     +     +  +                                             |  50        |
      C-Cell, Adenoma                      |                                                                          |          8 |
      C-Cell, Carcinoma                    |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +     +     +     +  +                                             |  50        |
      Adenoma                              |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Endometrium, Polyp Stromal           |       X                                                                  |          5 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |             +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Mesenteric, Leukemia Mononuclear     |       X     X                                                            |         14 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M     +     +     +  +                                             |  48        |
      Leukemia Mononuclear                 |             X                                                            |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |       X     X                                                            |         16 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +     +     +     +  +                                             |  46        |
      Leukemia Mononuclear                 |             X                                                            |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 5| 4| 7| 4| 7| 4| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 3| 4| 5| 3| 5| 3| 5| 3| 3|                                            |            |
                                           | 4| 1| 0| 8| 0| 9| 2| 9| 3| 3|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     A      |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +     +     +     +  +                                             |  50        |
      Adenocarcinoma                       |                                                                          |          1 |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |                            X                                             |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +     +     +  +                                             |  50        |
      Subcutaneous Tissue,                 |                                                                          |            |
          Neurofibrosarcoma                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +     +     +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |       X     X                                                            |         13 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +     +     +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +     +     +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +                                                                        |   1        |
      Squamous Cell Carcinoma              | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +     +     +     +  +                                             |  50        |
      Leukemia Mononuclear                 |       X     X                                                            |         16 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 6| 1| 4| 4| 6| 7| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 3| 6| 9| 6| 5| 5| 4| 3| 3| 3| 4| 3| 5| 4| 3| 0| 2| 0| 5| 3| 3| 3| 3|             
                                           | 9| 3| 1| 3| 3| 5| 8| 8| 0| 0| 3| 0| 8| 2| 8| 8| 1| 6| 9| 8| 8| 0| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |       X                 X                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +        +  +  +  +  M  +     +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +        +  +  +  +  M  +     +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +        +  +  +  +  M  +     +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma NOS                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Carcinoma                            |                                  X                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +        +  +  +  +  +  +     +  +  M  +  +     +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Pars Distalis, Adenoma               |    X     X  X              X     X           X        X  X     X  X  X   |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 6| 1| 4| 4| 6| 7| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 3| 6| 9| 6| 5| 5| 4| 3| 3| 3| 4| 3| 5| 4| 3| 0| 2| 0| 5| 3| 3| 3| 3|             
                                           | 9| 3| 1| 3| 3| 5| 8| 8| 0| 0| 3| 0| 8| 2| 8| 8| 1| 6| 9| 8| 8| 0| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      C-Cell, Adenoma                      |                                                                   X      |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +        M  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Granulosa Cell Tumor Malignant       |                                                                          |             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Leukemia Mononuclear                 |                         X                                                |             
      Endometrium, Polyp Stromal           |                                  X                             X         |             
      Endometrium, Sarcoma Stromal         |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |             +                                            +               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Mesenteric, Leukemia Mononuclear     |                         X                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +        M  +  +  +  +  +     +  +  M  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |       X                 X                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Adenocarcinoma                       |          X                                            X                  |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         | X                                   X                 X                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 5| 6| 1| 4| 4| 6| 7| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 3| 6| 9| 6| 5| 5| 4| 3| 3| 3| 4| 3| 5| 4| 3| 0| 2| 0| 5| 3| 3| 3| 3|             
                                           | 9| 3| 1| 3| 3| 5| 8| 8| 0| 0| 3| 0| 8| 2| 8| 8| 1| 6| 9| 8| 8| 0| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |       X                 X                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Mucosa, Squamous Cell Carcinoma      |                                        X                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                 +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Sarcoma                              |                                                                          |             
      Renal Tubule, Carcinoma              |                               X                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |       X                 X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 4| 7| 5| 4| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 6| 5| 3| 8| 5| 2| 3| 2| 3| 3| 3| 5| 3| 5| 6| 5| 2| 3| 2| 0| 0| 3| 3|             
                                           | 1| 9| 4| 8| 3| 4| 9| 3| 2| 1| 0| 1| 2| 9| 3| 2| 7| 9| 9| 2| 9| 6| 6| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                 X           X        X           X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                           X                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                             X                    X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                             X                           |             
      Pheochromocytoma NOS                 |       X                                                        X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +     +  +     +  +  M  M  +  M     +  +  M     M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X           X        X     X  X  X        X  X  X     X  X     X     X  X|             
      Pars Distalis, Leukemia Mononuclear  |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 4| 7| 5| 4| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 6| 5| 3| 8| 5| 2| 3| 2| 3| 3| 3| 5| 3| 5| 6| 5| 2| 3| 2| 0| 0| 3| 3|             
                                           | 1| 9| 4| 8| 3| 4| 9| 3| 2| 1| 0| 1| 2| 9| 3| 2| 7| 9| 9| 2| 9| 6| 6| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                      X                                                   |             
      C-Cell, Carcinoma                    |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M     M     +  +     +  +  M  M  +  +     +  +  +     +  +  +  +  M  +  +|             
      Adenoma                              |                                  X        X                    X         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Malignant       |                                              X           X               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                     X                                    |             
      Leukemia Mononuclear                 |                                                                          |             
      Endometrium, Polyp Stromal           |                                                                          |             
      Endometrium, Sarcoma Stromal         | X                                                                        |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                  X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Mesenteric, Leukemia Mononuclear     |                X                             X        X           X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M     M     +  M     +  +  +  +  +  +     +  M  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                 X           X        X           X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  M  +  M  M  +|             
      Leukemia Mononuclear                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                       X  X     X         |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         | X                             X                                         X|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                            X                                             |             
      Subcutaneous Tissue, Fibroma         |                                           X                              |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 4| 7| 5| 4| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 6| 5| 3| 8| 5| 2| 3| 2| 3| 3| 3| 5| 3| 5| 6| 5| 2| 3| 2| 0| 0| 3| 3|             
                                           | 1| 9| 4| 8| 3| 4| 9| 3| 2| 1| 0| 1| 2| 9| 3| 2| 7| 9| 9| 2| 9| 6| 6| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +     +  +     +  +  +  +  +  +        +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                             X                    X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Mucosa, Squamous Cell Carcinoma      |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                             X                    X      |             
      Sarcoma                              |                      X                                                   |             
      Renal Tubule, Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +     +  +     +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                 X           X        X           X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 3| 2| 3| 3| 2| 3| 3|                                            |            |
                                           | 9| 4| 3| 2| 9| 0| 3| 9| 3| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     A      |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |    X        X     X                                                      |         10 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                             |   2        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |    X                                                                     |          3 |
      Squamous Cell Carcinoma              |          X                                                               |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |    X                                                                     |          3 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |             +                                                            |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |    X                                                                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |    X                                                                     |          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |    X                                                                     |          3 |
      Pheochromocytoma NOS                 |                         X                                                |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 3| 2| 3| 3| 2| 3| 3|                                            |            |
                                           | 9| 4| 3| 2| 9| 0| 3| 9| 3| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     A      |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  M  M  +  +  +  +  +  +                                             |  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Pars Distalis, Adenoma               |    X        X  X  X  X  X                                                |         31 |
      Pars Distalis, Leukemia Mononuclear  |    X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +                                             |  50        |
      C-Cell, Adenoma                      |       X                                                                  |          3 |
      C-Cell, Carcinoma                    |             X                                                            |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +  +  +  +  +  +  +  +  +                                             |  44        |
      Adenoma                              |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Granulosa Cell Tumor Malignant       |                                                                          |          2 |
      Leukemia Mononuclear                 |    X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Adenocarcinoma                       |                                                                          |          1 |
      Leukemia Mononuclear                 |    X                                                                     |          2 |
      Endometrium, Polyp Stromal           |                                                                          |          2 |
      Endometrium, Sarcoma Stromal         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Mesenteric, Leukemia Mononuclear     |    X        X     X                                                      |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +  +  M  +  +  +  +                                             |  42        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |    X        X     X                                                      |         10 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +  +  +  +  +                                             |  46        |
      Leukemia Mononuclear                 |    X                                                                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 3| 2| 3| 3| 2| 3| 3|                                            |            |
                                           | 9| 4| 3| 2| 9| 0| 3| 9| 3| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     A      |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Adenocarcinoma                       |                      X                                                   |          6 |
      Adenoma                              |                         X                                                |          1 |
      Fibroadenoma                         |             X                                                            |          7 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Keratoacanthoma                      |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Lipoma          |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |    X                                                                     |          6 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Mucosa, Squamous Cell Carcinoma      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |    X                                                                     |          5 |
      Sarcoma                              |                                                                          |          1 |
      Renal Tubule, Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |    X                                                                     |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |    X        X     X                                                      |         10 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 5| 6| 7| 7| 6| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 3| 3| 8| 5| 3| 3| 2| 3| 5| 3| 7| 2|             
                                           | 9| 0| 9| 0| 3| 0| 2| 2| 3| 5| 3| 1| 1| 8| 1| 9| 2| 3| 1| 5| 0| 9| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Adenocarcinoma, Mucinous             |                               X                                          |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Hepatocellular Adenoma               |                         X                       X                        |             
      Leukemia Mononuclear                 |       X                    X                             X        X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Carcinoma Adenosquamous, Metastatic, |                                                                          |             
           Lung                            |                                                                          |             
      Leukemia Mononuclear                 |                            X                                      X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |       X                    X                                      X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                            X                                      X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 5| 6| 7| 7| 6| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 3| 3| 8| 5| 3| 3| 2| 3| 5| 3| 7| 2|             
                                           | 9| 0| 9| 0| 3| 0| 2| 2| 3| 5| 3| 1| 1| 8| 1| 9| 2| 3| 1| 5| 0| 9| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma NOS                 |                   X     X                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Pars Distalis, Adenoma               |                   X  X                    X  X  X     X     X        X  X|             
      Pars Distalis, Leukemia Mononuclear  |                                                                   X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |             X                 X              X        X                  |             
      Follicle, Adenoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|    X  X  X  X     X  X  X  X  X  X        X        X  X     X     X     X|             
      Interstitial Cell, Adenoma           |                X                    X                    X               |             
      Serosa, Mesothelioma Malignant       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |             +        +                 +                                 |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                            X                                      X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Carcinoma Adenosquamous, Metastatic, |                                                                          |             
           Lung                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                   X      |             
      Mediastinal, Leukemia Mononuclear    |                            X                                      X      |             
      Mesenteric, Leukemia Mononuclear     |       X                    X                                      X      |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                  X                                       |             
      Renal, Leukemia Mononuclear          |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  M  +  +  M  +     +  M  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 5| 6| 7| 7| 6| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 3| 3| 8| 5| 3| 3| 2| 3| 5| 3| 7| 2|             
                                           | 9| 0| 9| 0| 3| 0| 2| 2| 3| 5| 3| 1| 1| 8| 1| 9| 2| 3| 1| 5| 0| 9| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |       X                    X                             X        X      |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +|             
      Carcinoma Adenosquamous, Metastatic, |                                                                          |             
           Lung                            |                                                                          |             
      Leukemia Mononuclear                 |                            X                                      X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Fibroadenoma                         |             X                                                            |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                                          X               |             
      Thoracic, Subcutaneous Tissue,       |                                                                          |             
          Fibroma                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Carcinoma Adenosquamous              |                                                                          |             
      Leukemia Monocytic                   |                                                                          |             
      Leukemia Mononuclear                 |       X                    X                             X        X      |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Carcinoma Adenosquamous, Metastatic, |                                                                          |             
           Lung                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                     +                                    |             
      Carcinoma                            |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                            X                                      X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 5| 6| 7| 7| 6| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 5| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 3| 3| 8| 5| 3| 3| 2| 3| 5| 3| 7| 2|             
                                           | 9| 0| 9| 0| 3| 0| 2| 2| 3| 5| 3| 1| 1| 8| 1| 9| 2| 3| 1| 5| 0| 9| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Monocytic                   |                                                                          |             
      Leukemia Mononuclear                 |       X                    X                             X        X      |             
      Lymphoma Malignant Lymphocytic       |                                  X                                       |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 7| 7| 4| 6| 6| 7| 6| 4| 6| 7| 6| 7| 4| 6| 7| 7| 4| 7| 6| 6| 6| 4|             
                             DAY ON TEST   | 5| 3| 5| 3| 3| 7| 1| 6| 3| 7| 5| 2| 3| 7| 2| 5| 2| 3| 3| 5| 3| 1| 0| 7| 5|             
                                           | 9| 1| 8| 2| 2| 2| 4| 3| 2| 3| 8| 5| 2| 2| 9| 9| 2| 1| 3| 8| 0| 8| 2| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Adenocarcinoma, Mucinous             |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Hepatocellular Adenoma               |                         X                             X                  |             
      Leukemia Mononuclear                 |    X              X              X  X                          X  X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X                                                      |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Heart                                   |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Carcinoma Adenosquamous, Metastatic, |                                                                          |             
           Lung                            |                X                                                         |             
      Leukemia Mononuclear                 |    X              X                                   X           X  X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |    X              X                 X                 X        X  X  X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |    X              X                 X                          X  X  X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 7| 7| 4| 6| 6| 7| 6| 4| 6| 7| 6| 7| 4| 6| 7| 7| 4| 7| 6| 6| 6| 4|             
                             DAY ON TEST   | 5| 3| 5| 3| 3| 7| 1| 6| 3| 7| 5| 2| 3| 7| 2| 5| 2| 3| 3| 5| 3| 1| 0| 7| 5|             
                                           | 9| 1| 8| 2| 2| 2| 4| 3| 2| 3| 8| 5| 2| 2| 9| 9| 2| 1| 3| 8| 0| 8| 2| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma NOS                 |                                     X                          X     X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Adenoma                              |                                           X                    X         |             
      Carcinoma                            |                                                       X                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +     +  +  M  +  +  +  M     +  +  M  +     +  +  +     +  +  M  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Pars Distalis, Adenoma               |    X     X  X     X  X     X        X  X        X              X         |             
      Pars Distalis, Leukemia Mononuclear  |                                                                      X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |                                                             X            |             
      Follicle, Adenoma                    |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Testes                                  |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|                         X                             X     X        X   |             
      Interstitial Cell, Adenoma           |             X     X  X              X  X  X        X           X         |             
      Serosa, Mesothelioma Malignant       |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                           +                              |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |    X              X              X                                X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Carcinoma Adenosquamous, Metastatic, |                                                                          |             
           Lung                            |                X                                                         |             
      Leukemia Mononuclear                 |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                  X                                X      |             
      Mesenteric, Leukemia Mononuclear     |    X                             X                    X        X  X  X   |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    M     +  +  M  +  +  M  +     M  +  +  +     M  +  +     +  M  M  +   |             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 7| 7| 4| 6| 6| 7| 6| 4| 6| 7| 6| 7| 4| 6| 7| 7| 4| 7| 6| 6| 6| 4|             
                             DAY ON TEST   | 5| 3| 5| 3| 3| 7| 1| 6| 3| 7| 5| 2| 3| 7| 2| 5| 2| 3| 3| 5| 3| 1| 0| 7| 5|             
                                           | 9| 1| 8| 2| 2| 2| 4| 3| 2| 3| 8| 5| 2| 2| 9| 9| 2| 1| 3| 8| 0| 8| 2| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |    X              X              X  X                 X        X  X  X   |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +  +  +  +  +  +  M     +  +  M  +     +  +  +     +  +  +  +   |             
      Carcinoma Adenosquamous, Metastatic, |                                                                          |             
           Lung                            |                X                                                         |             
      Leukemia Mononuclear                 |    X                                                              X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Thoracic, Subcutaneous Tissue,       |                                                                          |             
          Fibroma                          |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Carcinoma Adenosquamous              |                X                                                         |             
      Leukemia Monocytic                   |                                     X                                    |             
      Leukemia Mononuclear                 |    X              X              X                    X        X  X  X   |             
                                            __________________________________________________________________________|             
   Nose                                    |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Carcinoma Adenosquamous, Metastatic, |                                                                          |             
           Lung                            |                X                                                         |             
      Leukemia Mononuclear                 |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                   X                                                  X   |             
      Sarcoma                              |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +     +  +  +  +  +  +  +     +  +  +  +     +  +  +     +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 4| 7| 7| 4| 6| 6| 7| 6| 4| 6| 7| 6| 7| 4| 6| 7| 7| 4| 7| 6| 6| 6| 4|             
                             DAY ON TEST   | 5| 3| 5| 3| 3| 7| 1| 6| 3| 7| 5| 2| 3| 7| 2| 5| 2| 3| 3| 5| 3| 1| 0| 7| 5|             
                                           | 9| 1| 8| 2| 2| 2| 4| 3| 2| 3| 8| 5| 2| 2| 9| 9| 2| 1| 3| 8| 0| 8| 2| 6| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Monocytic                   |                                     X                                    |             
      Leukemia Mononuclear                 |    X              X              X  X                 X        X  X  X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Mesothelioma Malignant               |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2|                                            |            |
                                           | 9| 7| 6| 8| 9| 1| 9| 1| 0| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     A      |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +        +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +        +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +        +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +        +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                X                                                         |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +        +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                X                                                         |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +        +  +  +  +  +                                             |  50        |
      Adenocarcinoma, Mucinous             |                                                                          |          1 |
      Leukemia Mononuclear                 |                X                                                         |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +        +  +  +  +  +                                             |  50        |
      Hepatocellular Adenoma               |                                                                          |          4 |
      Leukemia Mononuclear                 |       X        X  X  X  X                                                |         16 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +        +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
      Acinus, Adenoma                      |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +        +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +        +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          3 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +        +  +  +  +  +                                             |  50        |
      Carcinoma Adenosquamous, Metastatic, |                                                                          |            |
           Lung                            |                                                                          |          1 |
      Leukemia Mononuclear                 |       X        X                                                         |          9 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2|                                            |            |
                                           | 9| 7| 6| 8| 9| 1| 9| 1| 0| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     A      |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X        X  X     X                                                |         14 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |       X        X        X                                                |         11 |
      Pheochromocytoma NOS                 |                X     X                                                   |          7 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +        +  +  +  +  +                                             |  50        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M        +  +  +  +  +                                             |  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +  +  +  +  +                                             |  49        |
      Pars Distalis, Adenoma               |    X                 X  X                                                |         22 |
      Pars Distalis, Leukemia Mononuclear  |                X                                                         |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +        +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
      C-Cell, Adenoma                      |                                                                          |          5 |
      Follicle, Adenoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +        +  +  +  +  +                                             |  50        |
      Carcinoma                            |                      X                                                   |          1 |
      Leukemia Mononuclear                 |                X                                                         |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +        +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
      Bilateral, Interstitial Cell, Adenoma|                   X     X  X                                             |         23 |
      Interstitial Cell, Adenoma           | X              X                                                         |         13 |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +        +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X        X     X                                                   |         10 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +        +  +  +  +  +                                             |  50        |
      Carcinoma Adenosquamous, Metastatic, |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2|                                            |            |
                                           | 9| 7| 6| 8| 9| 1| 9| 1| 0| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     A      |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Lung                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          4 |
      Mesenteric, Leukemia Mononuclear     |       X        X  X  X  X                                                |         14 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M        +  +  +  +  +                                             |  36        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +        +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X        X  X  X  X                                                |         17 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +        +  +  +  +  +                                             |  44        |
      Carcinoma Adenosquamous, Metastatic, |                                                                          |            |
           Lung                            |                                                                          |          1 |
      Leukemia Mononuclear                 |       X        X                                                         |          6 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +        +  +  +  +  +                                             |  50        |
      Fibroadenoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +        +  +  +  +  +                                             |  50        |
      Subcutaneous Tissue, Fibroma         |                      X                                                   |          2 |
      Thoracic, Subcutaneous Tissue,       |                                                                          |            |
          Fibroma                          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +        +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +        +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          3 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +        +  +  +  +  +                                             |  50        |
      Carcinoma Adenosquamous              |                                                                          |          1 |
      Leukemia Monocytic                   |                                                                          |          1 |
      Leukemia Mononuclear                 |       X        X  X  X  X                                                |         16 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +        +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +        +  +  +  +  +                                             |  50        |
      Carcinoma Adenosquamous, Metastatic, |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 4| 4| 4| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2|                                            |            |
                                           | 9| 7| 6| 8| 9| 1| 9| 1| 0| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     A      |
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Lung                            |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                                                  |          3 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +        +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +        +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X        X                                                         |          5 |
      Sarcoma                              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +        +  +  +  +  +                                             |  50        |
      Leukemia Monocytic                   |                                                                          |          1 |
      Leukemia Mononuclear                 |       X        X  X  X  X                                                |         17 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 6| 7| 6| 7| 4| 7| 6| 7| 7| 4| 4| 7| 6| 6| 7| 7| 5| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 8| 2| 3| 8| 3| 5| 3| 8| 3| 2| 5| 7| 3| 2| 1| 3| 3| 7| 9| 7| 3| 7| 1| 1|             
                                           | 1| 3| 5| 1| 9| 0| 8| 2| 8| 3| 9| 9| 8| 0| 4| 8| 3| 1| 2| 8| 0| 2| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                X                                                         |             
      Histiocytic Sarcoma, Metastatic      | X                                                                        |             
      Leukemia Mononuclear                 |          X  X                 X     X     X  X  X     X  X     X     X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                 X           X                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                         X                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                 X     X     X  X  X                    X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Fibrosarcoma, Metastatic,   |                                                                          |             
           Skin                            |       X                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                               X                                          |             
      Leukemia Mononuclear                 |          X  X                 X     X     X                          X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X                 X     X     X                          X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 6| 7| 6| 7| 4| 7| 6| 7| 7| 4| 4| 7| 6| 6| 7| 7| 5| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 8| 2| 3| 8| 3| 5| 3| 8| 3| 2| 5| 7| 3| 2| 1| 3| 3| 7| 9| 7| 3| 7| 1| 1|             
                                           | 1| 3| 5| 1| 9| 0| 8| 2| 8| 3| 9| 9| 8| 0| 4| 8| 3| 1| 2| 8| 0| 2| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Malignant           |                               X                                          |             
      Pheochromocytoma NOS                 |                                                          X           X   |             
      Bilateral, Pheochromocytoma NOS      |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X              X     X  X  X  X           X  X        X           X  X  X|             
      Pars Distalis, Leukemia Mononuclear  |             X                                                            |             
      Pars Intermedia, Leukemia Mononuclear|             X                                                            |             
      Pars Nervosa, Leukemia Mononuclear   |             X                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
      C-Cell, Adenoma                      |          X                                                               |             
      C-Cell, Carcinoma                    |                X                                                         |             
      Follicle, Adenoma                    |          X                                                              X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |             X                       X                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                             X                              |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +                                                        +            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
      Bilateral, Interstitial Cell, Adenoma|       X  X     X                       X        X              X        X|             
      Interstitial Cell, Adenoma           |             X           X     X                    X     X  X        X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                           +                              |             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X                 X     X     X  X           X     X     X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |       X                                                                  |             
      Iliac, Leukemia Mononuclear          |                               X                                          |             
      Mediastinal, Leukemia Mononuclear    |                                           X  X        X                  |             
      Mesenteric, Leukemia Mononuclear     |             X                 X     X     X  X  X     X  X     X         |             
      Renal, Carcinoma, Metastatic, Kidney |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 6| 7| 6| 7| 4| 7| 6| 7| 7| 4| 4| 7| 6| 6| 7| 7| 5| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 8| 2| 3| 8| 3| 5| 3| 8| 3| 2| 5| 7| 3| 2| 1| 3| 3| 7| 9| 7| 3| 7| 1| 1|             
                                           | 1| 3| 5| 1| 9| 0| 8| 2| 8| 3| 9| 9| 8| 0| 4| 8| 3| 1| 2| 8| 0| 2| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +     +  +  +  +     M  +  M  +  +  +  M  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |             X                 X                 X                    X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Leukemia Mononuclear                 |          X  X                 X     X     X  X  X     X  X     X     X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Kidney        |                                                                      X   |             
      Leukemia Mononuclear                 |             X                       X     X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic      | X                                                                        |             
      Keratoacanthoma                      |                                        X                                 |             
      Subcutaneous Tissue, Fibrosarcoma    |       X                                            X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                       X        X                           |             
      Cerebrum, Astrocytoma Malignant      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic, Kidney        |                                                                      X   |             
      Fibrosarcoma, Metastatic, Skin       |       X                                                                  |             
      Histiocytic Sarcoma, Metastatic      | X                                                                        |             
      Leukemia Mononuclear                 |          X  X                 X     X     X  X  X     X  X     X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                 X                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |          +                                               +               |             
      Carcinoma                            |          X                                               X               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic      | X                                                                        |             
      Leukemia Mononuclear                 |             X                       X     X  X                           |             
      Capsule, Fibrosarcoma, Metastatic,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 2| 6| 7| 6| 7| 4| 7| 6| 7| 7| 4| 4| 7| 6| 6| 7| 7| 5| 6| 5| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 8| 2| 3| 8| 3| 5| 3| 8| 3| 2| 5| 7| 3| 2| 1| 3| 3| 7| 9| 7| 3| 7| 1| 1|             
                                           | 1| 3| 5| 1| 9| 0| 8| 2| 8| 3| 9| 9| 8| 0| 4| 8| 3| 1| 2| 8| 0| 2| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
           Skin                            |       X                                                                  |             
      Renal Tubule, Adenoma                |                                                    X                     |             
      Transitional Epithelium, Carcinoma   |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |       X                                                                  |             
      Leukemia Mononuclear                 |             X                 X              X                           |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X                 X     X     X  X  X     X  X     X     X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 4| 0| 6|             
                             DAY ON TEST   | 2| 7| 3| 3| 3| 2| 2| 9| 3| 9| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 5| 2| 8|             
                                           | 9| 0| 3| 2| 3| 9| 9| 8| 3| 8| 1| 9| 1| 0| 1| 2| 8| 2| 3| 9| 0| 1| 8| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Hepatocellular Carcinoma             |                               X                                          |             
      Hepatocellular Adenoma               |                                                                X         |             
      Histiocytic Sarcoma, Metastatic      |                                                                          |             
      Leukemia Mononuclear                 |    X     X        X  X  X  X           X  X  X                 X        X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Leukemia Mononuclear                 |    X                                                                    X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Leukemia Mononuclear                 |    X                    X                    X                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Leukemia Mononuclear                 |    X              X  X  X  X           X     X                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Capsule, Fibrosarcoma, Metastatic,   |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |    X              X  X  X  X           X     X                          X|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Leukemia Mononuclear                 |    X              X  X  X  X           X     X                          X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 4| 0| 6|             
                             DAY ON TEST   | 2| 7| 3| 3| 3| 2| 2| 9| 3| 9| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 5| 2| 8|             
                                           | 9| 0| 3| 2| 3| 9| 9| 8| 3| 8| 1| 9| 1| 0| 1| 2| 8| 2| 3| 9| 0| 1| 8| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma NOS                 |    X     X                                X                              |             
      Bilateral, Pheochromocytoma NOS      |                      X                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Adenoma                              | X                                                                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +     +  M  +  +     +  +     +  M     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Pars Distalis, Adenoma               |    X           X  X           X     X  X           X  X     X           X|             
      Pars Distalis, Leukemia Mononuclear  |                         X                    X                           |             
      Pars Intermedia, Leukemia Mononuclear|                                                                          |             
      Pars Nervosa, Leukemia Mononuclear   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      C-Cell, Adenoma                      |          X           X              X                       X  X        X|             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicle, Adenoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                   +                                                      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X     X     X     X  X  X  X     X  X        X        X|             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Leukemia Mononuclear                 |    X                    X                    X                          X|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                      X                       X                           |             
      Mesenteric, Leukemia Mononuclear     |    X              X  X  X  X           X     X                          X|             
      Renal, Carcinoma, Metastatic, Kidney |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 4| 0| 6|             
                             DAY ON TEST   | 2| 7| 3| 3| 3| 2| 2| 9| 3| 9| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 5| 2| 8|             
                                           | 9| 0| 3| 2| 3| 9| 9| 8| 3| 8| 1| 9| 1| 0| 1| 2| 8| 2| 3| 9| 0| 1| 8| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     M  +|             
      Leukemia Mononuclear                 |    X                 X  X  X                 X                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Hemangiosarcoma                      |                            X                                             |             
      Leukemia Mononuclear                 |    X     X        X  X  X  X           X     X                 X        X|             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     M  +     +  +|             
      Carcinoma, Metastatic, Kidney        |                                                                          |             
      Leukemia Mononuclear                 |    X                 X  X                    X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Histiocytic Sarcoma, Metastatic      |                                                                          |             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Leukemia Mononuclear                 |                         X                                               X|             
      Cerebrum, Astrocytoma Malignant      |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                             X            |             
      Carcinoma, Metastatic, Kidney        |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Histiocytic Sarcoma, Metastatic      |                                                                          |             
      Leukemia Mononuclear                 |    X     X        X  X  X  X           X  X  X                          X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Leukemia Mononuclear                 |    X                 X                                                   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Histiocytic Sarcoma, Metastatic      |                                                                          |             
      Leukemia Mononuclear                 |    X                    X                    X                          X|             
      Capsule, Fibrosarcoma, Metastatic,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 4| 0| 6|             
                             DAY ON TEST   | 2| 7| 3| 3| 3| 2| 2| 9| 3| 9| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 5| 2| 8|             
                                           | 9| 0| 3| 2| 3| 9| 9| 8| 3| 8| 1| 9| 1| 0| 1| 2| 8| 2| 3| 9| 0| 1| 8| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    600 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
           Skin                            |                                                                          |             
      Renal Tubule, Adenoma                |                                                                          |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Leukemia Mononuclear                 |    X                    X  X           X     X                           |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +     +  +     +  +|             
      Leukemia Mononuclear                 |    X     X        X  X  X  X           X  X  X                 X        X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 4| 4| 7| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3|                                            |            |
                                           | 3| 9| 4| 8| 9| 3| 8| 0| 2| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     A      |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +        +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +        +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                         X                                                |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +        +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                         X                                                |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +        +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +        +     +  +  +                                             |  50        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Histiocytic Sarcoma, Metastatic      |                                                                          |          1 |
      Leukemia Mononuclear                 |       X        X        X                                                |         25 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   2        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +        +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                 X                                                |          7 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +        +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +        +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                 X                                                |          7 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +        +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                 X                                                |          4 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +        +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X        X        X                                                |         17 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +        +     +  +  +                                             |  50        |
      Capsule, Fibrosarcoma, Metastatic,   |                                                                          |            |
           Skin                            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  49                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 4| 4| 7| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3|                                            |            |
                                           | 3| 9| 4| 8| 9| 3| 8| 0| 2| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     A      |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +        +     +  +  +                                             |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                 X                                                |         16 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +        +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                 X                                                |         16 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma NOS                 |                         X  X                                             |          7 |
      Bilateral, Pheochromocytoma NOS      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +        +     +  +  +                                             |  50        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     M        +     +  +  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +        +     +  +  +                                             |  50        |
      Pars Distalis, Adenoma               |       X                    X                                             |         24 |
      Pars Distalis, Leukemia Mononuclear  |       X                 X                                                |          5 |
      Pars Intermedia, Leukemia Mononuclear|                                                                          |          1 |
      Pars Nervosa, Leukemia Mononuclear   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +        +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
      C-Cell, Adenoma                      |                                                                          |          7 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicle, Adenoma                    |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +        +     +  +  +                                             |  50        |
      Adenoma                              |                            X                                             |          1 |
      Leukemia Mononuclear                 |                         X                                                |          3 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +        +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                      +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +        +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                         X                                                |          2 |
      Bilateral, Interstitial Cell, Adenoma| X              X     X                                                   |         27 |
      Interstitial Cell, Adenoma           |                         X  X                                             |          9 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  50                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 4| 4| 7| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3|                                            |            |
                                           | 3| 9| 4| 8| 9| 3| 8| 0| 2| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     A      |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +        +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                 X                                                |         15 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +        +     +  +  +                                             |  50        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          5 |
      Mesenteric, Leukemia Mononuclear     |       X        X        X                                                |         20 |
      Renal, Carcinoma, Metastatic, Kidney |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +        +     +  +  +                                             |  45        |
      Leukemia Mononuclear                 |       X                 X                                                |         11 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +        +     +  +  +                                             |  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |       X        X     X  X                                                |         25 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +        M     +  +  M                                             |  46        |
      Carcinoma, Metastatic, Kidney        |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                 X                                                |          9 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     M        +     +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +        +     +  +  +                                             |  50        |
      Histiocytic Sarcoma, Metastatic      |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +        +     +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +        +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                 X                                                |          7 |
      Cerebrum, Astrocytoma Malignant      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +        +     +  +  +                                             |  50        |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Carcinoma, Metastatic, Kidney        |                                                                          |          1 |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  51                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 4| 4| 7| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3|                                            |            |
                                           | 3| 9| 4| 8| 9| 3| 8| 0| 2| 2|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     A      |
    600 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma, Metastatic      |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                 X                                                |         22 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +        +     +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +        +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          5 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   2        |
      Carcinoma                            |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +        +     +  +  +                                             |  50        |
      Histiocytic Sarcoma, Metastatic      |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                 X                                                |         10 |
      Capsule, Fibrosarcoma, Metastatic,   |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
      Transitional Epithelium, Carcinoma   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +        +     +  +  +                                             |  50        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                 X                                                |         10 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +        +     +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X        X     X  X                                                |         26 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  52                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 5| 6| 4| 6|             
                             DAY ON TEST   | 3| 3| 9| 3| 5| 2| 4| 4| 9| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 2| 5| 9| 7| 5| 5|             
                                           | 3| 1| 1| 2| 8| 2| 0| 3| 6| 2| 2| 2| 0| 9| 6| 1| 6| 1| 1| 6| 2| 7| 1| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                      X  X     X  X  X  X           X     X  X           X|             
      Serosa, Mesothelioma Malignant       |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                               X                             X            |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                             X            |             
      Serosa, Mesothelioma Malignant       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                         X                                   X            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                      X  X                                X  X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Capsule, Mesothelioma Malignant      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                      X  X     X                    X     X  X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                      X  X     X                    X     X  X            |             
      Pheochromocytoma NOS                 | X                          X        X                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 5| 6| 4| 6|             
                             DAY ON TEST   | 3| 3| 9| 3| 5| 2| 4| 4| 9| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 2| 5| 9| 7| 5| 5|             
                                           | 3| 1| 1| 2| 8| 2| 0| 3| 6| 2| 2| 2| 0| 9| 6| 1| 6| 1| 1| 6| 2| 7| 1| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Pars Distalis, Adenoma               |          X     X     X           X        X     X              X        X|             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Distalis, Leukemia Monocytic    |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                               X                    X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      C-Cell, Adenoma                      |                               X                 X     X     X           X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X        X        X  X  X  X  X  X     X     X  X     X     X     X|             
      Interstitial Cell, Adenoma           |                   X                       X              X     X         |             
      Serosa, Mesothelioma Malignant       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                   +                                                      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                      X  X                          X     X  X           X|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                             X            |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Mesenteric, Leukemia Mononuclear     |                      X  X     X  X  X              X     X  X           X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  M  M  M  +  +  +  +  +  M  +  M  +  +  +  +  M  +     +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                      X  X     X  X  X  X           X     X  X           X|             
      Lymphoma Malignant                   |                                                                          |             
      Capsule, Mesothelioma Malignant      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                      X  X                                                |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 4| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 5| 6| 4| 6|             
                             DAY ON TEST   | 3| 3| 9| 3| 5| 2| 4| 4| 9| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 2| 5| 9| 7| 5| 5|             
                                           | 3| 1| 1| 2| 8| 2| 0| 3| 6| 2| 2| 2| 0| 9| 6| 1| 6| 1| 1| 6| 2| 7| 1| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Tail, Squamous Cell Papilloma        |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                      X                                   X               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Carcinoma Adenosquamous              |                                                 X                        |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
      Leukemia Mononuclear                 |                      X  X     X  X                 X     X  X           X|             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                   X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                          X  X            |             
      Capsule, Mesothelioma Malignant      |                                                                          |             
      Renal Tubule, Adenoma                |                               X                                         X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                         X                                X               |             
      Serosa, Mesothelioma Malignant       |                                                                          |             
      Transitional Epithelium, Papilloma   |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Monocytic                   |                                                                          |             
      Leukemia Mononuclear                 |                      X  X     X  X  X  X           X     X  X           X|             
      Lymphoma Malignant                   |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 5| 7| 4| 4| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 2| 5| 3| 9| 3| 2| 0| 3| 2| 5| 5| 3| 6| 3| 0| 5| 1| 5| 7| 3| 2| 3|             
                                           | 8| 9| 8| 6| 8| 2| 7| 0| 9| 4| 3| 9| 9| 9| 3| 0| 2| 8| 6| 5| 9| 8| 3| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                   X        X  X                    X  X                  |             
      Serosa, Mesothelioma Malignant       |                                                                X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +  +                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                X         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Serosa, Mesothelioma Malignant       |                                                                X         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X  X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Capsule, Mesothelioma Malignant      |                                                                X         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                   X        X                       X                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                   X        X                       X                     |             
      Pheochromocytoma NOS                 |          X              X                                X               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Adenoma                              |                      X     X                                             |             
      Carcinoma                            |                X                                                         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          +  M  +  +  +  +  +  +  M        +  +  +  M  +  +     M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 5| 7| 4| 4| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 2| 5| 3| 9| 3| 2| 0| 3| 2| 5| 5| 3| 6| 3| 0| 5| 1| 5| 7| 3| 2| 3|             
                                           | 8| 9| 8| 6| 8| 2| 7| 0| 9| 4| 3| 9| 9| 9| 3| 0| 2| 8| 6| 5| 9| 8| 3| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Pars Distalis, Adenoma               |             X  X        X  X                 X           X     X         |             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Distalis, Leukemia Monocytic    |                            X                                             |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      C-Cell, Adenoma                      |                      X        X  X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|          X        X  X        X  X              X     X  X        X  X  X|             
      Interstitial Cell, Adenoma           |             X           X  X                       X                     |             
      Serosa, Mesothelioma Malignant       |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |          +                                            +                  |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                   X        X                       X  X                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                                      |             
      Mediastinal, Leukemia Mononuclear    |                                                    X                     |             
      Mesenteric, Leukemia Mononuclear     |                   X        X  X                    X  X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +  M  M  M  +  +  +  +  +        +  M  +  +  M  +     +  +  +  +|             
      Leukemia Mononuclear                 |                            X                       X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                   X        X  X                    X  X                  |             
      Lymphoma Malignant                   |                                                       X                  |             
      Capsule, Mesothelioma Malignant      |                                                                X         |             
                                            __________________________________________________________________________|             
   Thymus                                  |          M  +  +  +  +  +  +  +  +        +  +  +  +  +  M     +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 5| 7| 4| 4| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 2| 5| 3| 9| 3| 2| 0| 3| 2| 5| 5| 3| 6| 3| 0| 5| 1| 5| 7| 3| 2| 3|             
                                           | 8| 9| 8| 6| 8| 2| 7| 0| 9| 4| 3| 9| 9| 9| 3| 0| 2| 8| 6| 5| 9| 8| 3| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    1200 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                      X                                                   |             
      Tail, Squamous Cell Papilloma        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Carcinoma Adenosquamous              |                                                                          |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |          X                                                               |             
      Leukemia Mononuclear                 |                   X        X                       X  X                  |             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |          +                                                               |             
      Carcinoma                            |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                   X        X                                             |             
      Capsule, Mesothelioma Malignant      |                                                                X         |             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
      Serosa, Mesothelioma Malignant       |                                                                X         |             
      Transitional Epithelium, Papilloma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |          +  +  +  +  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +|             
      Leukemia Monocytic                   |                            X                                             |             
      Leukemia Mononuclear                 |                   X        X  X                    X  X                  |             
      Lymphoma Malignant                   |                                                       X                  |             
      Mesothelioma Malignant               |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 4| 2| 6| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5|                                            |            |
                                           | 5| 0| 1| 9| 8| 5| 1| 9| 1| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |     A      |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +                                                |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +                                                |  49        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +                                                |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 | X     X           X  X                                                   |         19 |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 | X                                                                        |          3 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +                                                |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +                                                |  49        |
      Leukemia Mononuclear                 |                   X                                                      |          3 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |                   X                                                      |          7 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +                                                |  50        |
      Capsule, Mesothelioma Malignant      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 | X                                                                        |         10 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 | X                                                                        |         10 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 4| 2| 6| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5|                                            |            |
                                           | 5| 0| 1| 9| 8| 5| 1| 9| 1| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |     A      |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma NOS                 |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +                                                |  50        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +     +  +  +  +                                                |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  +                                                |  50        |
      Pars Distalis, Adenoma               | X  X                    X                                                |         18 |
      Pars Distalis, Carcinoma             |          X                                                               |          1 |
      Pars Distalis, Leukemia Monocytic    |                                                                          |          1 |
      Pars Distalis, Leukemia Mononuclear  | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +                                                |  50        |
      C-Cell, Adenoma                      |                                                                          |          8 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Bilateral, Interstitial Cell, Adenoma|    X  X              X                                                   |         30 |
      Interstitial Cell, Adenoma           | X                 X                                                      |         10 |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                   +                                                      |   4        |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 | X                 X                                                      |         12 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
      Mesenteric, Leukemia Mononuclear     | X     X           X                                                      |         17 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M     M  +  +  +                                                |  37        |
      Leukemia Mononuclear                 |                   X                                                      |          4 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 | X     X           X  X                                                   |         19 |
      Lymphoma Malignant                   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 4| 2| 6| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5|                                            |            |
                                           | 5| 0| 1| 9| 8| 5| 1| 9| 1| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |     A      |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Capsule, Mesothelioma Malignant      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +  M  +  +                                                |  46        |
      Leukemia Mononuclear                 | X                                                                        |          4 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +     +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +                                                |  50        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Tail, Squamous Cell Papilloma        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +                                                |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                +                                                         |   1        |
      Fibrosarcoma                         |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 | X                                                                        |          3 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +                                                |  50        |
      Carcinoma Adenosquamous              |                                                                          |          1 |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Leukemia Mononuclear                 | X                 X                                                      |         14 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  +                                                |  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +                                                |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
NTP Experiment-Test: 05701-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              TOLUENE                                          Date: 05/01/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 07:05:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 4| 2| 6| 7| 6| 4|                                            |            |
                             DAY ON TEST   | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5|                                            |            |
                                           | 5| 0| 1| 9| 8| 5| 1| 9| 1| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |     A      |
    1200 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Capsule, Mesothelioma Malignant      |                                                                          |          1 |
      Renal Tubule, Adenoma                |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Serosa, Mesothelioma Malignant       |                                                                          |          1 |
      Transitional Epithelium, Papilloma   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +     +  +  +  +                                                |  50        |
      Leukemia Monocytic                   |                                                                          |          1 |
      Leukemia Mononuclear                 | X     X           X  X                                                   |         19 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  62                                                               
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