TR 371 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC TOLUENE DATE: 09/18/94
EXPERIMENT: 05701 TEST: 02 TIME: 13:26:23
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: 0570001 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 07272B
PATHOLOGIST: J. SAGARTZ CAS: 108883
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC TOLUENE DATE: 09/18/94
EXPERIMENT: 05701 TEST: 02 TIME: 13:26:23
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: 0570001 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 07272B
PATHOLOGIST: J. SAGARTZ CAS: 108883
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC TOLUENE DATE: 09/18/94
EXPERIMENT: 05701 TEST: 02 TIME: 13:26:23
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: 0570001 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 07272B
PATHOLOGIST: J. SAGARTZ CAS: 108883
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF TOLUENE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Testes Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Benign Tumors
Malignant Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
====================================================================================================
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/49 (14%) 8/50 (16%) 6/50 (12%) | 1/49 (2%) 0/48 (0%) 4/49 (8%) |
|ADJUSTED (b) | 21.6% 23.2% 24.6% | 3.0% 0.0% 10.9% |
|TERMINAL (d) | 5/29 (17%) 3/28 (11%) 4/22 (18%) | 1/33 (3%) 0/34 (0%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | 618 670 715 | 729 (T) --- 564 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.507 P=0.516 P=0.558 | P=0.071 P=0.494N P=0.157 |
|INCIDENTAL TUMOR | P=0.434N P=0.612 P=0.557N | P=0.102 P=0.494N P=0.201 |
|LOGISTIC REGRESSION | P=0.487N P=0.548 P=0.552N | P=0.086 P=0.494N P=0.186 |
|COCHRAN-ARMITAGE | P=0.427N | P=0.082 |
|FISHER EXACT | P=0.517 P=0.484N | P=0.505N P=0.181 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/49 (14%) 9/50 (18%) 6/50 (12%) | 1/49 (2%) 0/48 (0%) 4/49 (8%) |
|ADJUSTED (b) | 21.6% 26.3% 24.6% | 3.0% 0.0% 10.9% |
|TERMINAL (d) | 5/29 (17%) 4/28 (14%) 4/22 (18%) | 1/33 (3%) 0/34 (0%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | 618 670 715 | 729 (T) --- 564 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.497 P=0.410 P=0.558 | P=0.071 P=0.494N P=0.157 |
|INCIDENTAL TUMOR | P=0.446N P=0.497 P=0.557N | P=0.102 P=0.494N P=0.201 |
|LOGISTIC REGRESSION | P=0.491N P=0.442 P=0.552N | P=0.086 P=0.494N P=0.186 |
|COCHRAN-ARMITAGE | P=0.427N | P=0.082 |
|FISHER EXACT | P=0.410 P=0.484N | P=0.505N P=0.181 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) | 2/49 (4%) 4/50 (8%) 3/44 (7%) |
|ADJUSTED (b) | 0.0% 3.6% 0.0% | 6.3% 10.6% 9.7% |
|TERMINAL (d) | 0/30 (0%) 1/28 (4%) 0/22 (0%) | 2/32 (6%) 3/35 (9%) 2/29 (7%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- | 729 (T) 554 706 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.691 P=0.486 (e) | P=0.374 P=0.367 P=0.454 |
|INCIDENTAL TUMOR | P=0.691 P=0.486 (e) | P=0.356 P=0.283 P=0.484 |
|LOGISTIC REGRESSION | P=0.691 P=0.486 (e) | P=0.362 P=0.345 P=0.448 |
|COCHRAN-ARMITAGE | P=0.731 | P=0.364 |
|FISHER EXACT | P=0.500 (e) | P=0.349 P=0.449 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 0/50 (0%) | 2/49 (4%) 4/50 (8%) 3/44 (7%) |
|ADJUSTED (b) | 3.3% 3.6% 0.0% | 6.3% 10.6% 9.7% |
|TERMINAL (d) | 1/30 (3%) 1/28 (4%) 0/22 (0%) | 2/32 (6%) 3/35 (9%) 2/29 (7%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- | 729 (T) 554 706 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.395N P=0.747 P=0.562N | P=0.374 P=0.367 P=0.454 |
|INCIDENTAL TUMOR | P=0.395N P=0.747 P=0.562N | P=0.356 P=0.283 P=0.484 |
|LOGISTIC REGRESSION | P=0.395N P=0.747 P=0.562N | P=0.362 P=0.345 P=0.448 |
|COCHRAN-ARMITAGE | P=0.331N | P=0.364 |
|FISHER EXACT | P=0.753N P=0.500N | P=0.349 P=0.449 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 2/50 (4%) | 0/50 (0%) 0/49 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.6% 7.1% 8.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/30 (3%) 2/28 (7%) 1/22 (5%) | 0/33 (0%) 0/35 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 618 729 (T) 704 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.508 P=0.675 P=0.618 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.569 P=0.663 P=0.686N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.578 P=0.690N P=0.681 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.601 | (e) |
|FISHER EXACT | P=0.691N P=0.691N | (e) (e) |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 2/49 (4%) 1/50 (2%) |
|ADJUSTED (b) | 3.3% 0.0% 2.7% | 0.0% 5.7% 3.3% |
|TERMINAL (d) | 1/30 (3%) 0/28 (0%) 0/22 (0%) | 0/33 (0%) 2/35 (6%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 632 | --- 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.635 P=0.514N P=0.723 | P=0.333 P=0.251 P=0.481 |
|INCIDENTAL TUMOR | P=0.661N P=0.514N P=0.762N | P=0.333 P=0.251 P=0.481 |
|LOGISTIC REGRESSION | P=0.667 P=0.514N P=0.760 | P=0.333 P=0.251 P=0.481 |
|COCHRAN-ARMITAGE | P=0.669N | P=0.361 |
|FISHER EXACT | P=0.500N P=0.753N | P=0.242 P=0.500 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 3/50 (6%) | 0/50 (0%) 2/49 (4%) 1/50 (2%) |
|ADJUSTED (b) | 8.8% 7.1% 10.4% | 0.0% 5.7% 3.3% |
|TERMINAL (d) | 2/30 (7%) 2/28 (7%) 1/22 (5%) | 0/33 (0%) 2/35 (6%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | 618 729 (T) 632 | --- 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.487 P=0.525N P=0.571 | P=0.333 P=0.251 P=0.481 |
|INCIDENTAL TUMOR | P=0.563 P=0.537N P=0.655N | P=0.333 P=0.251 P=0.481 |
|LOGISTIC REGRESSION | P=0.568 P=0.488N P=0.649 | P=0.333 P=0.251 P=0.481 |
|COCHRAN-ARMITAGE | P=0.588N | P=0.361 |
|FISHER EXACT | P=0.500N P=0.661N | P=0.242 P=0.500 |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 3.6% 7.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 1/28 (4%) 1/22 (5%) | 0/33 (0%) 0/35 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 659 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.105 P=0.486 P=0.197 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.125 P=0.486 P=0.247 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.130 P=0.486 P=0.228 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.142 | (e) |
|FISHER EXACT | P=0.500 P=0.247 | (e) (e) |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 3.6% 7.4% | 0.0% 0.0% 3.3% |
|TERMINAL (d) | 0/30 (0%) 1/28 (4%) 1/22 (5%) | 0/33 (0%) 0/35 (0%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 659 | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.105 P=0.486 P=0.197 | P=0.254 (e) P=0.481 |
|INCIDENTAL TUMOR | P=0.125 P=0.486 P=0.247 | P=0.254 (e) P=0.481 |
|LOGISTIC REGRESSION | P=0.130 P=0.486 P=0.228 | P=0.254 (e) P=0.481 |
|COCHRAN-ARMITAGE | P=0.142 | P=0.269 |
|FISHER EXACT | P=0.500 P=0.247 | (e) P=0.500 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 0/50 (0%) | 2/50 (4%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 12.4% 7.1% 0.0% | 5.7% 8.6% 0.0% |
|TERMINAL (d) | 3/30 (10%) 2/28 (7%) 0/22 (0%) | 1/33 (3%) 3/35 (9%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 652 729 (T) --- | 710 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.061N P=0.358N P=0.101N | P=0.226N P=0.524 P=0.267N |
|INCIDENTAL TUMOR | P=0.051N P=0.332N P=0.079N | P=0.207N P=0.532 P=0.225N |
|LOGISTIC REGRESSION | P=0.042N* P=0.315N P=0.072N | P=0.226N P=0.506 P=0.256N |
|COCHRAN-ARMITAGE | P=0.037N* | P=0.202N |
|FISHER EXACT | P=0.339N P=0.059N | P=0.500 P=0.247N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 3/50 (6%) 0/50 (0%) | 2/50 (4%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 12.4% 10.7% 0.0% | 5.7% 8.6% 0.0% |
|TERMINAL (d) | 3/30 (10%) 3/28 (11%) 0/22 (0%) | 1/33 (3%) 3/35 (9%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 652 729 (T) --- | 710 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.081N P=0.526N P=0.101N | P=0.226N P=0.524 P=0.267N |
|INCIDENTAL TUMOR | P=0.070N P=0.501N P=0.079N | P=0.207N P=0.532 P=0.225N |
|LOGISTIC REGRESSION | P=0.056N P=0.473N P=0.072N | P=0.226N P=0.506 P=0.256N |
|COCHRAN-ARMITAGE | P=0.049N* | P=0.202N |
|FISHER EXACT | P=0.500N P=0.059N | P=0.500 P=0.247N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 3/50 (6%) 0/50 (0%) | 2/50 (4%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 12.4% 10.7% 0.0% | 5.7% 8.6% 0.0% |
|TERMINAL (d) | 3/30 (10%) 3/28 (11%) 0/22 (0%) | 1/33 (3%) 3/35 (9%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 652 729 (T) --- | 710 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.081N P=0.526N P=0.101N | P=0.226N P=0.524 P=0.267N |
|INCIDENTAL TUMOR | P=0.070N P=0.501N P=0.079N | P=0.207N P=0.532 P=0.225N |
|LOGISTIC REGRESSION | P=0.056N P=0.473N P=0.072N | P=0.226N P=0.506 P=0.256N |
|COCHRAN-ARMITAGE | P=0.049N* | P=0.202N |
|FISHER EXACT | P=0.500N P=0.059N | P=0.500 P=0.247N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 5.7% 2.8% 3.3% |
|TERMINAL (d) | 0/30 (0%) 0/28 (0%) 0/22 (0%) | 1/33 (3%) 0/35 (0%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 710 717 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.413N P=0.487N P=0.539N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.356N P=0.465N P=0.496N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.405N P=0.501N P=0.535N |
|COCHRAN-ARMITAGE | (e) | P=0.378N |
|FISHER EXACT | (e) (e) | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 1/50 (2%) 6/50 (12%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 6.1% 2.9% 17.7% |
|TERMINAL (d) | 0/30 (0%) 0/28 (0%) 0/22 (0%) | 2/33 (6%) 1/35 (3%) 4/30 (13%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 729 (T) 729 (T) 563 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.055 P=0.479N P=0.110 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.068 P=0.479N P=0.128 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.061 P=0.479N P=0.120 |
|COCHRAN-ARMITAGE | (e) | P=0.070 |
|FISHER EXACT | (e) (e) | P=0.500N P=0.134 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 4/50 (8%) 2/50 (4%) 7/50 (14%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 11.6% 5.6% 20.9% |
|TERMINAL (d) | 0/30 (0%) 0/28 (0%) 0/22 (0%) | 3/33 (9%) 1/35 (3%) 5/30 (17%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 710 717 563 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.151 P=0.317N P=0.213 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.189 P=0.302N P=0.253 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.162 P=0.332N P=0.228 |
|COCHRAN-ARMITAGE | (e) | P=0.187 |
|FISHER EXACT | (e) (e) | P=0.339N P=0.262 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) | 13/50 (26%) 4/50 (8%) 7/50 (14%) |
|ADJUSTED (b) | 3.3% 0.0% 0.0% | 35.8% 11.4% 20.4% |
|TERMINAL (d) | 1/30 (3%) 0/28 (0%) 0/22 (0%) | 10/33 (30%) 4/35 (11%) 5/30 (17%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- | 655 729 (T) 561 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.309N P=0.514N P=0.562N | P=0.094N P=0.013N* P=0.158N |
|INCIDENTAL TUMOR | P=0.309N P=0.514N P=0.562N | P=0.073N P=0.011N* P=0.114N |
|LOGISTIC REGRESSION | P=0.309N P=0.514N P=0.562N | P=0.084N P=0.014N* P=0.133N |
|COCHRAN-ARMITAGE | P=0.269N | P=0.067N |
|FISHER EXACT | P=0.500N P=0.500N | P=0.016N* P=0.105N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) | 13/50 (26%) 5/50 (10%) 8/50 (16%) |
|ADJUSTED (b) | 3.3% 0.0% 0.0% | 35.8% 13.9% 23.6% |
|TERMINAL (d) | 1/30 (3%) 0/28 (0%) 0/22 (0%) | 10/33 (30%) 4/35 (11%) 6/30 (20%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- | 655 717 561 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.309N P=0.514N P=0.562N | P=0.162N P=0.028N* P=0.231N |
|INCIDENTAL TUMOR | P=0.309N P=0.514N P=0.562N | P=0.124N P=0.022N* P=0.177N |
|LOGISTIC REGRESSION | P=0.309N P=0.514N P=0.562N | P=0.146N P=0.030N* P=0.203N |
|COCHRAN-ARMITAGE | P=0.269N | P=0.117N |
|FISHER EXACT | P=0.500N P=0.500N | P=0.033N* P=0.163N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) | 14/50 (28%) 6/50 (12%) 13/50 (26%) |
|ADJUSTED (b) | 3.3% 0.0% 0.0% | 38.6% 16.7% 36.6% |
|TERMINAL (d) | 1/30 (3%) 0/28 (0%) 0/22 (0%) | 11/33 (33%) 5/35 (14%) 9/30 (30%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- | 655 717 561 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.309N P=0.514N P=0.562N | P=0.546N P=0.032N* P=0.568 |
|INCIDENTAL TUMOR | P=0.309N P=0.514N P=0.562N | P=0.471N P=0.026N* P=0.524N |
|LOGISTIC REGRESSION | P=0.309N P=0.514N P=0.562N | P=0.515N P=0.035N* P=0.565N |
|COCHRAN-ARMITAGE | P=0.269N | P=0.452N |
|FISHER EXACT | P=0.500N P=0.500N | P=0.039N* P=0.500N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Ovary |
| Granulosa Cell Tumor Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | | 0.0% 0.0% 5.9% |
|TERMINAL (d) | | 0/33 (0%) 0/35 (0%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | | --- --- 652 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.085 (e) P=0.221 |
|INCIDENTAL TUMOR | | P=0.101 (e) P=0.253 |
|LOGISTIC REGRESSION | | P=0.094 (e) P=0.235 |
|COCHRAN-ARMITAGE | | P=0.095 |
|FISHER EXACT | | (e) P=0.247 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 22/49 (45%) 24/50 (48%) 18/50 (36%) | 31/50 (62%) 27/50 (54%) 31/50 (62%) |
|ADJUSTED (b) | 52.4% 59.7% 45.0% | 70.1% 62.3% 71.8% |
|TERMINAL (d) | 11/30 (37%) 13/28 (46%) 4/22 (18%) | 20/33 (61%) 19/35 (54%) 18/30 (60%) |
|FIRST INCIDENCE (DAYS) | 473 572 478 | 430 457 421 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.513N P=0.429 P=0.511N | P=0.362 P=0.243N P=0.381 |
|INCIDENTAL TUMOR | P=0.121N P=0.492 P=0.115N | P=0.512 P=0.229N P=0.560 |
|LOGISTIC REGRESSION | P=0.114N P=0.440 P=0.126N | P=0.505 P=0.275N P=0.540 |
|COCHRAN-ARMITAGE | P=0.212N | P=0.541 |
|FISHER EXACT | P=0.457 P=0.243N | P=0.272N P=0.582N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 22/49 (45%) 24/50 (48%) 19/50 (38%) | 31/50 (62%) 27/50 (54%) 31/50 (62%) |
|ADJUSTED (b) | 52.4% 59.7% 46.4% | 70.1% 62.3% 71.8% |
|TERMINAL (d) | 11/30 (37%) 13/28 (46%) 4/22 (18%) | 20/33 (61%) 19/35 (54%) 18/30 (60%) |
|FIRST INCIDENCE (DAYS) | 473 572 478 | 430 457 421 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.484 P=0.429 P=0.551 | P=0.362 P=0.243N P=0.381 |
|INCIDENTAL TUMOR | P=0.161N P=0.492 P=0.152N | P=0.512 P=0.229N P=0.560 |
|LOGISTIC REGRESSION | P=0.150N P=0.440 P=0.163N | P=0.505 P=0.275N P=0.540 |
|COCHRAN-ARMITAGE | P=0.276N | P=0.541 |
|FISHER EXACT | P=0.457 P=0.311N | P=0.272N P=0.582N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 8.9% 0.0% 2.4% | 0.0% 0.0% 3.3% |
|TERMINAL (d) | 2/30 (7%) 0/28 (0%) 0/22 (0%) | 0/33 (0%) 0/35 (0%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | 625 --- 597 | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.221N P=0.131N P=0.382N | P=0.254 (e) P=0.481 |
|INCIDENTAL TUMOR | P=0.173N P=0.139N P=0.301N | P=0.254 (e) P=0.481 |
|LOGISTIC REGRESSION | P=0.175N P=0.119N P=0.304N | P=0.254 (e) P=0.481 |
|COCHRAN-ARMITAGE | P=0.176N | P=0.269 |
|FISHER EXACT | P=0.121N P=0.309N | (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 5.9% 4.5% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 1/28 (4%) 1/22 (5%) | 0/33 (0%) 0/35 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | --- 625 729 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.298 P=0.232 P=0.438 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.339 P=0.218 P=0.438 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.351 P=0.238 P=0.438 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.360 | (e) |
|FISHER EXACT | P=0.247 P=0.500 | (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 8.9% 5.9% 6.9% | 0.0% 2.9% 3.3% |
|TERMINAL (d) | 2/30 (7%) 1/28 (4%) 1/22 (5%) | 0/33 (0%) 1/35 (3%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | 625 625 597 | --- 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.500N P=0.519N P=0.601N | P=0.309 P=0.512 P=0.481 |
|INCIDENTAL TUMOR | P=0.416N P=0.543N P=0.527N | P=0.309 P=0.512 P=0.481 |
|LOGISTIC REGRESSION | P=0.410N P=0.499N P=0.508N | P=0.309 P=0.512 P=0.481 |
|COCHRAN-ARMITAGE | P=0.406N | P=0.331 |
|FISHER EXACT | P=0.500N P=0.500N | P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 5.9% 4.5% | 0.0% 2.9% 0.0% |
|TERMINAL (d) | 0/30 (0%) 1/28 (4%) 1/22 (5%) | 0/33 (0%) 1/35 (3%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | --- 625 729 (T) | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.298 P=0.232 P=0.438 | P=0.721 P=0.512 (e) |
|INCIDENTAL TUMOR | P=0.339 P=0.218 P=0.438 | P=0.721 P=0.512 (e) |
|LOGISTIC REGRESSION | P=0.351 P=0.238 P=0.438 | P=0.721 P=0.512 (e) |
|COCHRAN-ARMITAGE | P=0.360 | P=0.731 |
|FISHER EXACT | P=0.247 P=0.500 | P=0.500 (e) |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 0.0% 6.7% |
|TERMINAL (d) | 0/30 (0%) 0/28 (0%) 0/22 (0%) | 0/33 (0%) 0/35 (0%) 2/30 (7%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.083 (e) P=0.217 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.083 (e) P=0.217 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.083 (e) P=0.217 |
|COCHRAN-ARMITAGE | (e) | P=0.095 |
|FISHER EXACT | (e) (e) | (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 36/50 (72%) 36/50 (72%) 40/50 (80%) | |
|ADJUSTED (b) | 94.6% 92.2% 95.1% | |
|TERMINAL (d) | 28/30 (93%) 25/28 (89%) 20/22 (91%) | |
|FIRST INCIDENCE (DAYS) | 614 570 495 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.013 * P=0.488 P=0.019 * | |
|INCIDENTAL TUMOR | P=0.052 P=0.541N P=0.073 | |
|LOGISTIC REGRESSION | P=0.072 P=0.435N P=0.096 | |
|COCHRAN-ARMITAGE | P=0.210 | |
|FISHER EXACT | P=0.588N P=0.241 | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 7/50 (14%) 8/50 (16%) | 2/50 (4%) 8/50 (16%) 3/50 (6%) |
|ADJUSTED (b) | 15.2% 22.3% 29.1% | 5.4% 20.0% 9.7% |
|TERMINAL (d) | 4/30 (13%) 5/28 (18%) 5/22 (23%) | 1/33 (3%) 5/35 (14%) 2/30 (7%) |
|FIRST INCIDENCE (DAYS) | 589 686 606 | 655 553 723 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.113 P=0.360 P=0.145 | P=0.379 P=0.061 P=0.457 |
|INCIDENTAL TUMOR | P=0.170 P=0.382 P=0.211 | P=0.445 P=0.040 * P=0.515 |
|LOGISTIC REGRESSION | P=0.194 P=0.404 P=0.245 | P=0.416 P=0.049 * P=0.470 |
|COCHRAN-ARMITAGE | P=0.231 | P=0.429 |
|FISHER EXACT | P=0.380 P=0.277 | P=0.046 * P=0.500 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) | 2/50 (4%) 2/50 (4%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 3.6% 0.0% | 5.3% 5.7% 6.7% |
|TERMINAL (d) | 0/30 (0%) 1/28 (4%) 0/22 (0%) | 1/33 (3%) 2/35 (6%) 2/30 (7%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- | 642 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.691 P=0.486 (e) | P=0.566 P=0.676N P=0.661 |
|INCIDENTAL TUMOR | P=0.691 P=0.486 (e) | P=0.581 P=0.611 P=0.680 |
|LOGISTIC REGRESSION | P=0.691 P=0.486 (e) | P=0.575 P=0.693 P=0.678 |
|COCHRAN-ARMITAGE | P=0.731 | P=0.601 |
|FISHER EXACT | P=0.500 (e) | P=0.691N P=0.691N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 8/50 (16%) 8/50 (16%) | 4/50 (8%) 10/50 (20%) 5/50 (10%) |
|ADJUSTED (b) | 15.2% 25.7% 29.1% | 10.5% 25.3% 16.1% |
|TERMINAL (d) | 4/30 (13%) 6/28 (21%) 5/22 (23%) | 2/33 (6%) 7/35 (20%) 4/30 (13%) |
|FIRST INCIDENCE (DAYS) | 589 686 606 | 642 553 723 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.111 P=0.257 P=0.145 | P=0.377 P=0.097 P=0.443 |
|INCIDENTAL TUMOR | P=0.167 P=0.274 P=0.211 | P=0.443 P=0.049 * P=0.500 |
|LOGISTIC REGRESSION | P=0.195 P=0.300 P=0.245 | P=0.414 P=0.075 P=0.463 |
|COCHRAN-ARMITAGE | P=0.236 | P=0.440 |
|FISHER EXACT | P=0.277 P=0.277 | P=0.074 P=0.500 |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.3% 6.6% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/30 (3%) 1/28 (4%) 0/22 (0%) | 0/33 (0%) 0/35 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 711 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.427N P=0.491 P=0.562N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.378N P=0.531 P=0.562N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.390N P=0.518 P=0.562N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.360N | (e) |
|FISHER EXACT | P=0.500 P=0.500N | (e) (e) |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 4/50 (8%) 5/50 (10%) 2/50 (4%) |
|ADJUSTED (b) | | 11.4% 11.6% 6.7% |
|TERMINAL (d) | | 3/33 (9%) 2/35 (6%) 2/30 (7%) |
|FIRST INCIDENCE (DAYS) | | 675 537 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.319N P=0.517 P=0.387N |
|INCIDENTAL TUMOR | | P=0.328N P=0.545 P=0.357N |
|LOGISTIC REGRESSION | | P=0.257N P=0.526 P=0.378N |
|COCHRAN-ARMITAGE | | P=0.283N |
|FISHER EXACT | | P=0.500 P=0.339N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 5/50 (10%) 5/50 (10%) 3/50 (6%) |
|ADJUSTED (b) | | 14.3% 11.6% 8.6% |
|TERMINAL (d) | | 4/33 (12%) 2/35 (6%) 2/30 (7%) |
|FIRST INCIDENCE (DAYS) | | 675 537 561 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.336N P=0.608N P=0.409N |
|INCIDENTAL TUMOR | | P=0.338N P=0.588N P=0.372N |
|LOGISTIC REGRESSION | | P=0.262N P=0.612N P=0.374N |
|COCHRAN-ARMITAGE | | P=0.297N |
|FISHER EXACT | | P=0.630N P=0.357N |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.2% 6.3% 4.2% | 2.2% 0.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 1/28 (4%) 0/22 (0%) | 0/33 (0%) 0/35 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 701 698 726 | 638 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.565 P=0.510 P=0.724 | P=0.282N P=0.504N P=0.519N |
|INCIDENTAL TUMOR | P=0.558N P=0.586 P=0.672N | P=0.276N P=0.748N P=0.473N |
|LOGISTIC REGRESSION | P=0.597 P=0.511 P=0.743 | P=0.241N P=0.484N P=0.470N |
|COCHRAN-ARMITAGE | P=0.622N | P=0.269N |
|FISHER EXACT | P=0.500 P=0.753N | P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 17/50 (34%) 26/50 (52%) 19/50 (38%) | 18/50 (36%) 16/50 (32%) 10/50 (20%) |
|ADJUSTED (b) | 41.3% 62.3% 52.1% | 42.6% 38.6% 26.4% |
|TERMINAL (d) | 8/30 (27%) 13/28 (46%) 7/22 (32%) | 10/33 (30%) 10/35 (29%) 5/30 (17%) |
|FIRST INCIDENCE (DAYS) | 416 478 495 | 491 540 584 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.184 P=0.085 P=0.231 | P=0.105N P=0.376N P=0.123N |
|INCIDENTAL TUMOR | P=0.485 P=0.041 * P=0.525 | P=0.048N* P=0.405N P=0.061N |
|LOGISTIC REGRESSION | P=0.374 P=0.053 P=0.429 | P=0.051N P=0.418N P=0.056N |
|COCHRAN-ARMITAGE | P=0.380 | P=0.050N* |
|FISHER EXACT | P=0.053 P=0.418 | P=0.417N P=0.059N |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 45/50 (90%) 46/50 (92%) 47/50 (94%) | 39/50 (78%) 37/50 (74%) 34/50 (68%) |
|ADJUSTED (b) | 100.0% 100.0% 97.9% | 86.6% 80.2% 77.1% |
|TERMINAL (d) | 30/30 (100%) 28/28 (100%) 21/22 (95%) | 27/33 (82%) 26/35 (74%) 20/30 (67%) |
|FIRST INCIDENCE (DAYS) | 473 570 478 | 430 457 421 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.038 * P=0.435 P=0.053 | P=0.416N P=0.330N P=0.462N |
|INCIDENTAL TUMOR | P=0.159 P=0.591 P=0.241 | P=0.189N P=0.322N P=0.197N |
|LOGISTIC REGRESSION | P=0.212 P=0.604 P=0.284 | P=0.190N P=0.418N P=0.238N |
|COCHRAN-ARMITAGE | P=0.290 | P=0.154N |
|FISHER EXACT | P=0.500 P=0.357 | P=0.408N P=0.184N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 600 PPM 1200 PPM | 0 PPM 600 PPM 1200 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 23/50 (46%) 32/50 (64%) 27/50 (54%) | 21/50 (42%) 21/50 (42%) 23/50 (46%) |
|ADJUSTED (b) | 54.5% 73.7% 63.3% | 48.8% 49.4% 57.6% |
|TERMINAL (d) | 12/30 (40%) 17/28 (61%) 8/22 (36%) | 12/33 (36%) 14/35 (40%) 14/30 (47%) |
|FIRST INCIDENCE (DAYS) | 416 478 205 | 491 414 561 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.098 P=0.096 P=0.134 | P=0.276 P=0.509N P=0.307 |
|INCIDENTAL TUMOR | P=0.350 P=0.034 * P=0.411 | P=0.369 P=0.575N P=0.414 |
|LOGISTIC REGRESSION | P=0.247 P=0.053 P=0.314 | P=0.369 P=0.578N P=0.406 |
|COCHRAN-ARMITAGE | P=0.241 | P=0.381 |
|FISHER EXACT | P=0.054 P=0.274 | P=0.580N P=0.420 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 49/50 (98%) 48/50 (96%) 49/50 (98%) | 46/50 (92%) 43/50 (86%) 43/50 (86%) |
|ADJUSTED (b) | 100.0% 100.0% 98.0% | 93.9% 86.0% 89.6% |
|TERMINAL (d) | 30/30 (100%) 28/28 (100%) 21/22 (95%) | 30/33 (91%) 28/35 (80%) 25/30 (83%) |
|FIRST INCIDENCE (DAYS) | 416 478 205 | 430 414 421 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.084 P=0.556N P=0.107 | P=0.482 P=0.273N P=0.500 |
|INCIDENTAL TUMOR | P=0.646N (e) P=0.726N | P=0.279N P=0.230N P=0.338N |
|LOGISTIC REGRESSION | P=0.548 (e) P=0.725 | P=0.226N P=0.260N P=0.306N |
|COCHRAN-ARMITAGE | P=0.622N | P=0.221N |
|FISHER EXACT | P=0.500N P=0.753N | P=0.262N P=0.262N |
|=================================================================================================================================|
DATE: 09/18/94 EXPERIMENT: 05701 TEST: 02 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- TOLUENE
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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