TR 371 Rat Pathology Tables
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
Facility: International Research and Development Corp.
Chemical CAS #: 108883
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 5| 2| 3| 2| 3| 5| 1| 0| 3| 5| 2| 4| 1| 3| 2| 3| 3| 3| 3|
| 0| 2| 8| 3| 0| 2| 9| 9| 0| 6| 2| 8| 0| 8| 1| 8| 9| 4| 9| 8| 9| 3| 2| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Developmental Malformation | X X X X X |
Fatty Change | 2 2 |
Focal Cellular Change | X 2 X X X X X X X X X X X|
Granuloma | 2 2 2 1 2 2 |
Hematopoietic Cell Proliferation | |
Necrosis | 2 2 2 |
Arteriole, Thrombosis | |
Bile Duct, Hyperplasia | 2 2 1 3 2 2 1 2 2 1 3 2 1 2 1|
Portal, Inflammation, Chronic | 1 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2 1 2 |
Venule, Thrombosis | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 4 3 2 2 2 2 |
Acinus, Hyperplasia | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
Inflammation, Chronic Active | |
Ulcer | 4 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Dilatation | 2 1 2 2 1 2 2 2 1 2 2 2 1 |
Mucosa, Erosion | 2 1 |
Mucosa, Pigmentation | 2 |
Mucosa, Ulcer | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 5| 2| 3| 2| 3| 5| 1| 0| 3| 5| 2| 4| 1| 3| 2| 3| 3| 3| 3|
| 0| 2| 8| 3| 0| 2| 9| 9| 0| 6| 2| 8| 0| 8| 1| 8| 9| 4| 9| 8| 9| 3| 2| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 2 2 2 2 2 1 1 3 3 1 1 2 2 2 2 1 1 1 2 2|
Inflammation, Acute | |
Mineralization | 2 |
Atrium, Thrombosis | |
Ventricle, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 3 4 2 2 1 2 2 2 1 1 2 1 4 2 2|
Hyperplasia | 2 2 2 2 2 2 1 2 |
Hypertrophy | 2 |
Pigmentation | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3|
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 3 3 2 2 |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute | 1 |
C-Cell, Hyperplasia | 1 1 2 2 2 1 2 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Acute | |
Inflammation, Chronic | 2 1 2 2 2 2 2 2 2|
Inflammation, Chronic Active | 3 3 2 2 |
Duct, Ectasia | 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Periovarian Tissue, Cyst | X X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 5| 2| 3| 2| 3| 5| 1| 0| 3| 5| 2| 4| 1| 3| 2| 3| 3| 3| 3|
| 0| 2| 8| 3| 0| 2| 9| 9| 0| 6| 2| 8| 0| 8| 1| 8| 9| 4| 9| 8| 9| 3| 2| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | |
Prolapse | |
Endometrium, Hyperplasia, Cystic | 2 2 |
__________________________________________________________________________|
Vagina | + + + |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 2 |
Myeloid Cell, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 2 2 2 |
Inflammation, Acute | |
Mediastinal, Hemorrhage | |
Mesenteric, Congestion | 2 |
Mesenteric, Edema | |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 1 2 2 2 2 2 |
Mesenteric, Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M M + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | |
Hyperplasia, Lymphoid | 2 3 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2|
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 1 3 4 2 2 2 3 2 2 1 2 2 2 2 2 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Reticulum Cell | 3 |
Pigmentation | 2 2 2 2 1 2 2 3 3 3 2 1 2 3 3 3 2 2 1|
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + M + + + + +|
Congestion | 2 |
Cyst | X |
Mediastinum, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | |
Acinus, Ectasia | 2 2 3 2 3 3 2 2 3 3 2 4 4 3 2 2 3 2|
Acinus, Hyperplasia | |
Duct, Ectasia | 2 4 2 2 2 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 5| 2| 3| 2| 3| 5| 1| 0| 3| 5| 2| 4| 1| 3| 2| 3| 3| 3| 3|
| 0| 2| 8| 3| 0| 2| 9| 9| 0| 6| 2| 8| 0| 8| 1| 8| 9| 4| 9| 8| 9| 3| 2| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Head, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X |
Cranium, Osteopetrosis | 3 4 |
Femur, Fibrous Osteodystrophy | X |
Femur, Osteopetrosis | 3 2 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X |
Gliosis | 3 |
Hemorrhage | |
Hydrocephalus | 2 |
Lateral Ventricle, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Hemorrhage | 2 1 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Pigmentation, Cholesterol | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 2 1 2 1 1 2 1 2 2 1|
Alveolus, Mineralization | |
Arteriole, Mineralization | 2 2 2 2 2 2 2 2 2 2 2 2 1 2|
Interstitium, Inflammation, Chronic | 1 1 1 1 1 2 1 1|
Interstitium, Inflammation, Chronic | |
Active | |
Peribronchiolar, Inflammation, Acute | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | 3 |
Lumen, Hemorrhage | 3 2 2 2 2 2 2 2 2 1 2 3|
Mucosa, Inflammation, Acute | 2 2 2 2 1 2 4 2 2 |
Nasolacrimal Duct, Hemorrhage | |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 1 3 1 2 |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 3 1 2 2 2 2 2 2 2 2 2 2 2 2|
Olfactory Epithelium, Erosion | 2 2 |
Respiratory Epithelium, Degeneration | 3 2 1 1 2 2 1 1 2 1 2 |
Respiratory Epithelium, Erosion | 3 |
Respiratory Epithelium, Metaplasia, | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 4| 7| 4| 6| 7| 4| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 5| 2| 3| 2| 3| 5| 1| 0| 3| 5| 2| 4| 1| 3| 2| 3| 3| 3| 3|
| 0| 2| 8| 3| 0| 2| 9| 9| 0| 6| 2| 8| 0| 8| 1| 8| 9| 4| 9| 8| 9| 3| 2| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | |
Cataract | 4 |
Retina, Degeneration | 4 |
Sclera, Mineralization | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Nephropathy, Chronic | 3 2 4 2 2 3 1 2 2 4 2 2 2 3 2 2 2 3 2 3 2|
Pelvis, Calculus Micro Observation | |
Only | |
Renal Tubule, Cyst | X |
Renal Tubule, Hyperplasia | 3 |
Renal Tubule, Pigmentation | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 4| 6| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 3| 3| 5| 3| 9| 7| 3| 3| 3| 5| 2| 2| 3| 3| 3| 6| 5| 7| 5| 3| 3| 3| 3| 5|
| 2| 0| 1| 9| 0| 7| 5| 0| 9| 2| 9| 9| 9| 3| 1| 1| 8| 8| 5| 8| 3| 1| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
Erosion | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 |
Developmental Malformation | X |
Fatty Change | 2 |
Focal Cellular Change | X X X X X X X X X X X X |
Granuloma | 2 2 1 1 2 2 |
Hematopoietic Cell Proliferation | 2 |
Necrosis | |
Arteriole, Thrombosis | |
Bile Duct, Hyperplasia | 1 2 1 2 1 2 1 2 1 2 2 2 2 1 2 1 |
Portal, Inflammation, Chronic | 2 2 2 2 1 1 1 2 1 2 2 2 2 2 2 2 2 1 2 |
Venule, Thrombosis | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Acinus, Atrophy | 2 4 2 3 4 1 1 2 |
Acinus, Hyperplasia | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Squamous | |
Inflammation, Chronic Active | 1 4 |
Ulcer | 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + |
Mucosa, Dilatation | 2 1 2 2 2 2 1 2 1 |
Mucosa, Erosion | 1 |
Mucosa, Pigmentation | |
Mucosa, Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 4| 6| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 3| 3| 5| 3| 9| 7| 3| 3| 3| 5| 2| 2| 3| 3| 3| 6| 5| 7| 5| 3| 3| 3| 3| 5|
| 2| 0| 1| 9| 0| 7| 5| 0| 9| 2| 9| 9| 9| 3| 1| 1| 8| 8| 5| 8| 3| 1| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy, Chronic | 3 2 2 2 2 1 1 2 1 1 3 3 2 2 2 3 2 2 3 |
Inflammation, Acute | |
Mineralization | |
Atrium, Thrombosis | |
Ventricle, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Degeneration, Fatty | 2 1 2 2 2 1 2 1 2 1 2 |
Hyperplasia | 2 1 1 2 1 |
Hypertrophy | 2 1 2 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + + + + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + M + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X X X |
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia | 2 2 3 |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Inflammation, Acute | |
C-Cell, Hyperplasia | 2 1 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + + + |
Cyst | |
Inflammation, Acute | 3 |
Inflammation, Chronic | 2 2 2 2 1 2 1 2 |
Inflammation, Chronic Active | 2 2 2 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + |
Periovarian Tissue, Cyst | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 4| 6| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 3| 3| 5| 3| 9| 7| 3| 3| 3| 5| 2| 2| 3| 3| 3| 6| 5| 7| 5| 3| 3| 3| 3| 5|
| 2| 0| 1| 9| 0| 7| 5| 0| 9| 2| 9| 9| 9| 3| 1| 1| 8| 8| 5| 8| 3| 1| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Ectasia | 2 |
Hemorrhage | 4 |
Prolapse | X |
Endometrium, Hyperplasia, Cystic | |
__________________________________________________________________________|
Vagina | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Myelofibrosis | 1 1 2 2 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Hyperplasia, Lymphoid | 2 2 |
Inflammation, Acute | |
Mediastinal, Hemorrhage | |
Mesenteric, Congestion | 1 2 |
Mesenteric, Edema | 3 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 |
Mesenteric, Inflammation, Acute | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + |
Congestion | 2 3 |
Cyst | X |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 2 3 1 2 2 2 2 3 2 3 2 2 3 3 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Reticulum Cell | |
Pigmentation | 3 2 2 2 2 2 3 2 2 3 2 2 3 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + M + + + + + |
Congestion | 2 |
Cyst | X |
Mediastinum, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Inflammation, Chronic Active | 3 |
Acinus, Ectasia | 3 2 2 4 2 3 3 2 3 2 3 3 |
Acinus, Hyperplasia | 2 2 |
Duct, Ectasia | 2 2 2 2 2 3 2 3 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 4| 6| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 3| 3| 5| 3| 9| 7| 3| 3| 3| 5| 2| 2| 3| 3| 3| 6| 5| 7| 5| 3| 3| 3| 3| 5|
| 2| 0| 1| 9| 0| 7| 5| 0| 9| 2| 9| 9| 9| 3| 1| 1| 8| 8| 5| 8| 3| 1| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Head, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
Cranium, Fibrous Osteodystrophy | |
Cranium, Osteopetrosis | |
Femur, Fibrous Osteodystrophy | |
Femur, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Compression | X X X |
Gliosis | |
Hemorrhage | 3 2 2 2 |
Hydrocephalus | |
Lateral Ventricle, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Hemorrhage | 1 2 1 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Pigmentation, Cholesterol | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 2 1 2 1 2 2 |
Alveolus, Mineralization | |
Arteriole, Mineralization | 2 2 2 2 2 1 2 |
Interstitium, Inflammation, Chronic | 1 1 1 2 1 1 2 |
Interstitium, Inflammation, Chronic | |
Active | |
Peribronchiolar, Inflammation, Acute | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Lumen, Foreign Body | |
Lumen, Hemorrhage | 3 2 3 2 2 2 1 1 3 2 2 2 4 |
Mucosa, Inflammation, Acute | 2 2 2 1 2 2 2 3 1 2 1 2 |
Nasolacrimal Duct, Hemorrhage | |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 |
Olfactory Epithelium, Erosion | |
Respiratory Epithelium, Degeneration | 1 1 1 2 1 1 2 1 1 1 1 2 2 1 |
Respiratory Epithelium, Erosion | 2 |
Respiratory Epithelium, Metaplasia, | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 4| 6| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 3| 3| 5| 3| 9| 7| 3| 3| 3| 5| 2| 2| 3| 3| 3| 6| 5| 7| 5| 3| 3| 3| 3| 5|
| 2| 0| 1| 9| 0| 7| 5| 0| 9| 2| 9| 9| 9| 3| 1| 1| 8| 8| 5| 8| 3| 1| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 2 |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Atrophy | 4 |
Cataract | 4 3 |
Retina, Degeneration | 4 2 4 |
Sclera, Mineralization | 3 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Nephropathy, Chronic | 2 3 2 2 3 2 2 1 2 3 3 3 2 2 3 3 2 2 3 3 |
Pelvis, Calculus Micro Observation | |
Only | X |
Renal Tubule, Cyst | X |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| | |
DAY ON TEST | 8| 9| 3| 2| 3| 5| 5| 2| 2| 3| | |
| 3| 1| 2| 9| 3| 5| 9| 9| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 50 |
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 50 |
Parasite Metazoan | | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 50 |
Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 50 |
Erosion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Angiectasis | | 2 2.0|
Developmental Malformation | | 6 |
Fatty Change | | 3 2.0|
Focal Cellular Change | X X X X | 29 2.0|
Granuloma | | 12 1.8|
Hematopoietic Cell Proliferation | | 1 2.0|
Necrosis | 2 | 4 2.0|
Arteriole, Thrombosis | X | 1 |
Bile Duct, Hyperplasia | 3 1 1 2 2 2 2 | 38 1.7|
Portal, Inflammation, Chronic | 2 1 2 2 2 1 3 2 | 47 1.8|
Venule, Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 50 |
Acinus, Atrophy | 2 2 1 | 18 2.2|
Acinus, Hyperplasia | 3 | 1 3.0|
Duct, Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
Hyperplasia, Squamous | | 1 3.0|
Inflammation, Chronic Active | | 2 2.5|
Ulcer | 4 | 6 3.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 50 |
Mucosa, Dilatation | 2 2 1 2 2 | 27 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| | |
DAY ON TEST | 8| 9| 3| 2| 3| 5| 5| 2| 2| 3| | |
| 3| 1| 2| 9| 3| 5| 9| 9| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Erosion | 3 3 3 | 6 2.2|
Mucosa, Pigmentation | | 1 2.0|
Mucosa, Ulcer | 2 | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Cardiomyopathy, Chronic | 2 2 3 2 2 2 2 2 | 48 1.9|
Inflammation, Acute | 4 | 1 4.0|
Mineralization | | 1 2.0|
Atrium, Thrombosis | X X | 2 |
Ventricle, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 50 |
Degeneration, Fatty | 1 1 2 2 2 2 2 | 33 1.8|
Hyperplasia | 1 1 3 | 16 1.7|
Hypertrophy | | 4 1.8|
Pigmentation | 2 2 2 2 2 2 2 2 2 | 50 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 49 |
Hyperplasia | | 4 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + M + + + M | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 50 |
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Cyst | | 10 |
Pars Distalis, Hemorrhage | 3 4 | 3 3.3|
Pars Distalis, Hyperplasia | | 7 2.4|
Pars Intermedia, Angiectasis | 3 | 1 3.0|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Acute | | 1 1.0|
C-Cell, Hyperplasia | 1 1 1 | 17 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| | |
DAY ON TEST | 8| 9| 3| 2| 3| 5| 5| 2| 2| 3| | |
| 3| 1| 2| 9| 3| 5| 9| 9| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + | 49 |
Cyst | | 1 |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | 2 2 2 1 | 21 1.8|
Inflammation, Chronic Active | 2 3 | 10 2.3|
Duct, Ectasia | | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 50 |
Periovarian Tissue, Cyst | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 50 |
Ectasia | | 2 2.0|
Hemorrhage | | 1 4.0|
Prolapse | | 1 |
Endometrium, Hyperplasia, Cystic | | 2 2.0|
__________________________________________________________________________|____________|
Vagina | + | 4 |
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + M + + + + + + + | 49 |
Myelofibrosis | 2 4 | 8 2.0|
Myeloid Cell, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 50 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | | 6 2.0|
Inflammation, Acute | 4 | 1 4.0|
Mediastinal, Hemorrhage | 4 | 1 4.0|
Mesenteric, Congestion | 2 | 4 1.8|
Mesenteric, Edema | | 1 3.0|
Mesenteric, Hyperplasia, Lymphoid | 2 | 17 1.9|
Mesenteric, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + | 47 |
Congestion | 2 2 | 5 2.2|
Cyst | | 1 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 | 41 2.0|
Inflammation, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | 2 3 3 2 2 3 2 2 | 41 2.2|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Reticulum Cell | | 1 3.0|
Pigmentation | 3 2 2 2 1 1 2 | 44 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| | |
DAY ON TEST | 8| 9| 3| 2| 3| 5| 5| 2| 2| 3| | |
| 3| 1| 2| 9| 3| 5| 9| 9| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + | 46 |
Congestion | 3 2 | 4 2.3|
Cyst | | 2 |
Mediastinum, Inflammation, Chronic | | |
Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 50 |
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
Acinus, Ectasia | 2 2 3 2 2 2 3 | 37 2.6|
Acinus, Hyperplasia | 3 | 3 2.3|
Duct, Ectasia | 2 2 2 2 3 | 21 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Head, Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + M + + + + + + + | 49 |
Cranium, Fibrous Osteodystrophy | | 1 |
Cranium, Osteopetrosis | | 2 3.5|
Femur, Fibrous Osteodystrophy | | 1 |
Femur, Osteopetrosis | | 3 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
Compression | X X | 11 |
Gliosis | | 1 3.0|
Hemorrhage | 2 | 5 2.2|
Hydrocephalus | | 1 2.0|
Lateral Ventricle, Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Congestion | 2 3 3 | 5 2.6|
Hemorrhage | 2 | 7 1.6|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 | 49 2.0|
Pigmentation, Cholesterol | 2 | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 1 1 1 1 2 3 | 28 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| | |
DAY ON TEST | 8| 9| 3| 2| 3| 5| 5| 2| 2| 3| | |
| 3| 1| 2| 9| 3| 5| 9| 9| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Mineralization | 1 | 1 1.0|
Arteriole, Mineralization | 1 2 2 2 | 25 1.9|
Interstitium, Inflammation, Chronic | 2 1 | 17 1.2|
Interstitium, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
Peribronchiolar, Inflammation, Acute | | 2 4.0|
__________________________________________________________________________|____________|
Nose | + M + + + + + + + | 49 |
Lumen, Foreign Body | 2 2 3 | 4 2.5|
Lumen, Hemorrhage | 2 2 1 2 2 | 30 2.1|
Mucosa, Inflammation, Acute | 3 2 2 2 1 4 | 27 2.0|
Nasolacrimal Duct, Hemorrhage | 1 | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 5 1.8|
Olfactory Epithelium, Degeneration | 2 2 2 2 1 2 2 | 44 2.0|
Olfactory Epithelium, Erosion | | 2 2.0|
Respiratory Epithelium, Degeneration | 1 1 1 2 | 29 1.4|
Respiratory Epithelium, Erosion | 2 2 | 4 2.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
Hemorrhage | | 1 2.0|
Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 5 |
Atrophy | | 1 4.0|
Cataract | | 3 3.7|
Retina, Degeneration | | 4 3.5|
Sclera, Mineralization | | 2 2.5|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Inflammation, Acute | 3 | 1 3.0|
Nephropathy, Chronic | 2 3 4 2 1 2 3 4 | 49 2.4|
Pelvis, Calculus Micro Observation | | |
Only | | 1 |
Renal Tubule, Cyst | | 2 |
Renal Tubule, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| | |
DAY ON TEST | 8| 9| 3| 2| 3| 5| 5| 2| 2| 3| | |
| 3| 1| 2| 9| 3| 5| 9| 9| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Pigmentation | 2 3 2 2 1 2 2 3 2 | 49 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4|
DAY ON TEST | 8| 5| 3| 3| 2| 3| 5| 3| 3| 5| 3| 5| 3| 2| 5| 2| 3| 3| 3| 3| 3| 5| 3| 5| 5|
| 1| 7| 0| 3| 9| 2| 8| 2| 3| 8| 2| 4| 0| 9| 3| 9| 3| 1| 1| 3| 0| 8| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 3 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 3 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X X X |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + |
Edema | |
Erosion | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + |
Edema | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + |
Edema | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 |
Congestion | 2 |
Developmental Malformation | X X |
Fatty Change | 3 |
Focal Cellular Change | X X X X X X X X X X X X X X X X X |
Granuloma | 2 2 2 2 2 2 |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | |
Necrosis | 4 |
Bile Duct, Hyperplasia | 2 2 1 2 1 1 1 1 2 1 1 1 2 3 1 |
Portal, Inflammation, Chronic | 2 2 2 2 1 1 2 2 1 2 1 2 2 2 2 2 3 2 1 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
Acinus, Atrophy | 2 2 4 3 3 3 2 1 1 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + |
Hyperkeratosis | 2 |
Hyperplasia, Squamous | |
Inflammation, Acute | |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4|
DAY ON TEST | 8| 5| 3| 3| 2| 3| 5| 3| 3| 5| 3| 5| 3| 2| 5| 2| 3| 3| 3| 3| 3| 5| 3| 5| 5|
| 1| 7| 0| 3| 9| 2| 8| 2| 3| 8| 2| 4| 0| 9| 3| 9| 3| 1| 1| 3| 0| 8| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Mucosa, Dilatation | 2 2 1 1 1 1 2 2 2 2 2 2 2 2 |
Mucosa, Erosion | 2 2 |
__________________________________________________________________________|
Tooth | |
Pulp, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy, Chronic | 2 2 2 2 2 1 2 2 1 2 2 2 3 2 2 2 2 1 2 1 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Degeneration, Fatty | 1 2 2 2 4 2 1 2 1 1 3 |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | 4 |
Hyperplasia | 2 2 2 2 2 2 2 2 1 2 2 2 |
Hypertrophy | 2 2 2 2 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + M + |
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + M + + + + + + M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 2 2 3 |
Pars Distalis, Cyst | X X X X X X |
Pars Distalis, Hyperplasia | 3 3 3 3 3 3 2 3 |
Pars Distalis, Metaplasia, Osseous | 2 |
Pars Intermedia, Angiectasis | 3 |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 1 4 2 1 2 1 1 1 2 2 2 |
Follicle, Ectasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4|
DAY ON TEST | 8| 5| 3| 3| 2| 3| 5| 3| 3| 5| 3| 5| 3| 2| 5| 2| 3| 3| 3| 3| 3| 5| 3| 5| 5|
| 1| 7| 0| 3| 9| 2| 8| 2| 3| 8| 2| 4| 0| 9| 3| 9| 3| 1| 1| 3| 0| 8| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
Inflammation, Chronic | 2 1 2 2 2 1 |
Inflammation, Chronic Active | 2 2 2 2 4 1 2 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + |
Ectasia | 2 |
Endometrium, Hyperplasia, Cystic | |
Endometrium, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Vagina | + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
Myelofibrosis | 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Hyperplasia, Lymphoid | 2 2 |
Pigmentation | |
Mediastinal, Congestion | |
Mediastinal, Hyperplasia, Lymphoid | |
Mesenteric, Congestion | |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 |
Mesenteric, Inflammation, Acute | 3 |
Renal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + |
Congestion | 2 3 2 |
Cyst | |
Hyperplasia, Lymphoid | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 1 4 3 3 3 2 2 2 4 2 3 1 3 2 2 4 4 3 2 2 |
Hyperplasia, Lymphoid | |
Infarct | |
Pigmentation | 3 2 2 2 2 2 2 1 2 2 2 3 2 2 2 2 3 2 3 2 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + M + + + |
Congestion | 4 |
Cyst | X |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4|
DAY ON TEST | 8| 5| 3| 3| 2| 3| 5| 3| 3| 5| 3| 5| 3| 2| 5| 2| 3| 3| 3| 3| 3| 5| 3| 5| 5|
| 1| 7| 0| 3| 9| 2| 8| 2| 3| 8| 2| 4| 0| 9| 3| 9| 3| 1| 1| 3| 0| 8| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Acinus, Ectasia | 2 2 4 2 2 2 2 2 2 2 2 2 2 4 |
Acinus, Hyperplasia | |
Duct, Ectasia | 2 3 3 2 3 2 2 2 3 2 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Head, Inflammation, Chronic Active | |
Lip, Inflammation, Chronic Active | 2 |
Subcutaneous Tissue, Head, Granuloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
Cranium, Osteopetrosis | 4 |
Femur, Osteopetrosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Compression | X X |
Hemorrhage | 1 2 2 |
Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Congestion | 4 |
Hemorrhage | 1 3 1 1 |
Infiltration Cellular | 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 2 1 1 1 2 2 1 |
Arteriole, Mineralization | 2 2 2 2 2 2 2 1 2 2 2 |
Interstitium, Inflammation, Chronic | 1 1 1 |
Interstitium, Inflammation, Chronic | |
Active | |
Peribronchiolar, Inflammation, Acute | |
Peribronchiolar, Inflammation, | |
Chronic | 4 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
Lumen, Foreign Body | |
Lumen, Hemorrhage | 1 3 2 2 2 4 3 2 3 2 2 2 2 2 2 2 |
Mucosa, Inflammation, Acute | 1 1 3 1 2 2 3 2 2 2 2 3 2 3 2 2 3 |
Mucosa, Inflammation | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Nasolacrimal Duct, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4|
DAY ON TEST | 8| 5| 3| 3| 2| 3| 5| 3| 3| 5| 3| 5| 3| 2| 5| 2| 3| 3| 3| 3| 3| 5| 3| 5| 5|
| 1| 7| 0| 3| 9| 2| 8| 2| 3| 8| 2| 4| 0| 9| 3| 9| 3| 1| 1| 3| 0| 8| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Chronic Active | |
Olfactory Epithelium, Degeneration | 2 2 2 3 2 2 3 2 3 1 3 3 2 3 2 3 2 2 2 2 3 |
Olfactory Epithelium, Erosion | 2 2 2 2 2 |
Olfactory Epithelium, Metaplasia | |
Olfactory Epithelium, Metaplasia, | |
Squamous | 2 |
Respiratory Epithelium, Degeneration | 1 1 1 1 1 3 1 1 3 3 1 1 3 3 1 1 3 2 1 1 |
Respiratory Epithelium, Erosion | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Atrophy | |
Cataract | 3 |
Hemorrhage | 3 |
Retina, Degeneration | 4 4 |
Sclera, Mineralization | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Nephropathy, Chronic | 1 2 3 1 3 3 3 3 1 3 2 2 3 3 2 3 2 3 2 3 4 |
Pelvis, Calculus Micro Observation | |
Only | |
Renal Tubule, Hyperplasia | |
Renal Tubule, Hypertrophy | 2 |
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4|
DAY ON TEST | 2| 5| 5| 3| 5| 1| 3| 2| 3| 3| 3| 3| 5| 7| 1| 3| 3| 7| 3| 3| 2| 8| 2| 3| 5|
| 9| 3| 3| 3| 9| 7| 0| 9| 1| 7| 0| 2| 8| 6| 1| 2| 1| 9| 2| 3| 9| 1| 9| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X X |
Ulcer | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + |
Edema | 3 |
Erosion | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + |
Edema | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + |
Edema | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 3 2 2 2 |
Congestion | |
Developmental Malformation | X |
Fatty Change | 1 4 |
Focal Cellular Change | X X X X X X X X X X X X X X X X X X |
Granuloma | 2 1 1 2 2 3 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 |
Necrosis | |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 1 2 2 2 2 1 2 2 |
Portal, Inflammation, Chronic | 2 2 2 2 1 2 2 1 1 1 2 2 2 2 2 2 3 1 2 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + |
Acinus, Atrophy | 3 4 2 2 2 2 1 3 2 3 2 2 |
Acinus, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + |
Hyperkeratosis | |
Hyperplasia, Squamous | 2 3 |
Inflammation, Acute | 2 4 4 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4|
DAY ON TEST | 2| 5| 5| 3| 5| 1| 3| 2| 3| 3| 3| 3| 5| 7| 1| 3| 3| 7| 3| 3| 2| 8| 2| 3| 5|
| 9| 3| 3| 3| 9| 7| 0| 9| 1| 7| 0| 2| 8| 6| 1| 2| 1| 9| 2| 3| 9| 1| 9| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 4 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 3 |
Mucosa, Dilatation | 1 1 1 2 2 2 2 2 2 2 |
Mucosa, Erosion | 2 4 |
__________________________________________________________________________|
Tooth | + |
Pulp, Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy, Chronic | 2 2 3 2 2 1 2 2 2 2 2 1 3 2 2 2 2 2 2 2 2 2 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + |
Degeneration, Fatty | 2 2 1 2 2 1 2 2 2 2 2 1 1 2 2 1 1 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hyperplasia | 2 2 2 1 1 2 2 |
Hypertrophy | 1 2 2 |
Pigmentation | 2 2 2 1 2 2 2 2 1 2 2 1 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + M + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 3 2 2 3 2 3 |
Pars Distalis, Metaplasia, Osseous | |
Pars Intermedia, Angiectasis | 3 |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 1 2 1 2 1 1 2 2 |
Follicle, Ectasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4|
DAY ON TEST | 2| 5| 5| 3| 5| 1| 3| 2| 3| 3| 3| 3| 5| 7| 1| 3| 3| 7| 3| 3| 2| 8| 2| 3| 5|
| 9| 3| 3| 3| 9| 7| 0| 9| 1| 7| 0| 2| 8| 6| 1| 2| 1| 9| 2| 3| 9| 1| 9| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 |
Inflammation, Chronic | 2 2 2 2 1 2 1 2 1 2 2 |
Inflammation, Chronic Active | 2 2 3 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + |
Ectasia | |
Endometrium, Hyperplasia, Cystic | 3 2 |
Endometrium, Inflammation, Chronic | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + |
Myelofibrosis | 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Hyperplasia, Lymphoid | |
Pigmentation | |
Mediastinal, Congestion | 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mesenteric, Congestion | 2 2 2 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 |
Mesenteric, Inflammation, Acute | |
Renal, Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 2 2 2 |
Cyst | X |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 2 2 3 2 3 2 3 2 2 2 2 1 2 2 2 2 4 2 3 |
Hyperplasia, Lymphoid | 2 |
Infarct | 4 |
Pigmentation | 2 3 2 2 3 2 3 2 2 2 1 1 2 3 2 2 2 2 |
Capsule, Fibrosis | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M M + + + |
Congestion | |
Cyst | X |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4|
DAY ON TEST | 2| 5| 5| 3| 5| 1| 3| 2| 3| 3| 3| 3| 5| 7| 1| 3| 3| 7| 3| 3| 2| 8| 2| 3| 5|
| 9| 3| 3| 3| 9| 7| 0| 9| 1| 7| 0| 2| 8| 6| 1| 2| 1| 9| 2| 3| 9| 1| 9| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Acinus, Ectasia | 4 2 4 2 3 2 2 2 2 2 2 2 2 2 2 |
Acinus, Hyperplasia | 2 |
Duct, Ectasia | 2 2 2 3 2 2 2 2 2 2 3 2 3 4 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + |
Head, Inflammation, Chronic Active | 3 |
Lip, Inflammation, Chronic Active | |
Subcutaneous Tissue, Head, Granuloma | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + |
Cranium, Osteopetrosis | |
Femur, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + |
Compression | X X X X |
Hemorrhage | 1 4 |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + |
Congestion | 3 3 |
Hemorrhage | 1 3 2 |
Infiltration Cellular | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Metaplasia, Osseous | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 2 1 2 2 1 1 |
Arteriole, Mineralization | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1 |
Interstitium, Inflammation, Chronic | 1 1 1 1 1 |
Interstitium, Inflammation, Chronic | |
Active | 1 2 |
Peribronchiolar, Inflammation, Acute | 1 |
Peribronchiolar, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + |
Lumen, Foreign Body | 2 |
Lumen, Hemorrhage | 2 2 2 2 1 1 3 2 2 1 2 2 2 2 |
Mucosa, Inflammation, Acute | 2 2 2 2 2 3 2 2 2 2 2 2 2 3 2 3 2 2 2 |
Mucosa, Inflammation | |
Nasolacrimal Duct, Inflammation, | |
Acute | 1 2 |
Nasolacrimal Duct, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 4| 7| 7| 7| 7| 5| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 4|
DAY ON TEST | 2| 5| 5| 3| 5| 1| 3| 2| 3| 3| 3| 3| 5| 7| 1| 3| 3| 7| 3| 3| 2| 8| 2| 3| 5|
| 9| 3| 3| 3| 9| 7| 0| 9| 1| 7| 0| 2| 8| 6| 1| 2| 1| 9| 2| 3| 9| 1| 9| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Chronic Active | 2 |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 2 3 2 2 2 2 2 3 2 2 2 2 2 2 2 3 |
Olfactory Epithelium, Erosion | 2 1 2 |
Olfactory Epithelium, Metaplasia | 2 |
Olfactory Epithelium, Metaplasia, | |
Squamous | |
Respiratory Epithelium, Degeneration | 2 1 1 1 1 1 3 2 1 1 2 1 1 2 3 1 1 1 1 3 |
Respiratory Epithelium, Erosion | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Atrophy | 4 |
Cataract | 3 |
Hemorrhage | |
Retina, Degeneration | 4 |
Sclera, Mineralization | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + |
Nephropathy, Chronic | 2 1 2 3 3 2 3 2 2 3 3 3 2 3 3 2 4 2 2 4 3 4 |
Pelvis, Calculus Micro Observation | |
Only | X |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Hypertrophy | |
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 4| 7| 5| 4| 7| 4| 7| 4| 7| 7| | |
DAY ON TEST | 1| 3| 4| 5| 3| 5| 3| 5| 3| 3| | |
| 4| 1| 0| 8| 0| 9| 2| 9| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 50 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + | 49 |
Inflammation, Acute | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + | 49 |
Inflammation, Acute | | 1 3.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + | 50 |
Parasite Metazoan | | 5 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + | 49 |
Edema | | 1 3.0|
Erosion | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + | 49 |
Edema | | 1 3.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + | 49 |
Edema | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + | 50 |
Angiectasis | 2 | 6 2.2|
Congestion | | 1 2.0|
Developmental Malformation | X X | 5 |
Fatty Change | | 3 2.7|
Focal Cellular Change | X X X X X 1 | 41 1.0|
Granuloma | 2 | 13 1.9|
Hematopoietic Cell Proliferation | 1 | 2 1.0|
Hemorrhage | | 1 2.0|
Necrosis | | 1 4.0|
Bile Duct, Hyperplasia | 1 1 3 2 1 | 36 1.7|
Portal, Inflammation, Chronic | 2 2 2 2 2 2 | 46 1.8|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | M + + + + + + | 49 |
Acinus, Atrophy | 2 2 2 | 24 2.3|
Acinus, Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 4| 7| 5| 4| 7| 4| 7| 4| 7| 7| | |
DAY ON TEST | 1| 3| 4| 5| 3| 5| 3| 5| 3| 3| | |
| 4| 1| 0| 8| 0| 9| 2| 9| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 50 |
Hyperkeratosis | | 1 2.0|
Hyperplasia, Squamous | | 2 2.5|
Inflammation, Acute | | 3 3.3|
Inflammation, Chronic Active | | 1 3.0|
Ulcer | | 5 3.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 50 |
Inflammation, Acute | | 1 3.0|
Mucosa, Dilatation | 2 2 | 26 1.7|
Mucosa, Erosion | | 4 2.5|
__________________________________________________________________________|____________|
Tooth | | 1 |
Pulp, Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 50 |
Cardiomyopathy, Chronic | 2 1 3 2 2 2 3 | 50 2.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + M + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + M + + + | 49 |
Degeneration, Fatty | 3 1 1 | 31 1.7|
Hematopoietic Cell Proliferation | | 1 1.0|
Hemorrhage | | 1 4.0|
Hyperplasia | | 19 1.8|
Hypertrophy | 2 2 | 9 1.9|
Pigmentation | 2 2 2 2 2 | 48 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + | 48 |
Hyperplasia | | 4 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | M + + + + + + | 49 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 50 |
Pars Distalis, Angiectasis | | 3 2.3|
Pars Distalis, Cyst | X X X X X | 14 |
Pars Distalis, Hyperplasia | 2 3 2 | 17 2.6|
Pars Distalis, Metaplasia, Osseous | | 1 2.0|
Pars Intermedia, Angiectasis | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 4| 7| 5| 4| 7| 4| 7| 4| 7| 7| | |
DAY ON TEST | 1| 3| 4| 5| 3| 5| 3| 5| 3| 3| | |
| 4| 1| 0| 8| 0| 9| 2| 9| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Nervosa, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 50 |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia | 1 2 | 23 1.7|
Follicle, Ectasia | 3 | 4 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + | 50 |
Hyperplasia | | 2 2.0|
Inflammation, Chronic | 2 1 2 | 20 1.7|
Inflammation, Chronic Active | 2 | 14 2.2|
__________________________________________________________________________|____________|
Ovary | + + + + + + + | 50 |
Periovarian Tissue, Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + | 50 |
Ectasia | | 1 2.0|
Endometrium, Hyperplasia, Cystic | | 2 2.5|
Endometrium, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 50 |
Myelofibrosis | 2 1 2 1 | 9 1.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 50 |
Congestion | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 | 3 2.0|
Pigmentation | 2 | 1 2.0|
Mediastinal, Congestion | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mesenteric, Congestion | | 3 2.0|
Mesenteric, Hyperplasia, Lymphoid | 2 3 2 2 | 32 2.1|
Mesenteric, Inflammation, Acute | | 1 3.0|
Renal, Congestion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + | 48 |
Congestion | 2 | 8 2.1|
Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 4| 7| 5| 4| 7| 4| 7| 4| 7| 7| | |
DAY ON TEST | 1| 3| 4| 5| 3| 5| 3| 5| 3| 3| | |
| 4| 1| 0| 8| 0| 9| 2| 9| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 3 3 2 2 | 42 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 50 |
Fibrosis | 4 | 3 3.3|
Hematopoietic Cell Proliferation | 3 2 2 3 3 3 | 46 2.5|
Hyperplasia, Lymphoid | | 1 2.0|
Infarct | | 1 4.0|
Pigmentation | 2 2 2 2 2 1 | 44 2.1|
Capsule, Fibrosis | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + | 46 |
Congestion | 3 | 2 3.5|
Cyst | | 2 |
Hyperplasia, Lymphoid | 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 50 |
Acinus, Ectasia | 1 3 2 2 4 | 34 2.3|
Acinus, Hyperplasia | | 1 2.0|
Duct, Ectasia | 2 3 2 | 31 2.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + | 50 |
Head, Inflammation, Chronic Active | | 1 3.0|
Lip, Inflammation, Chronic Active | | 1 2.0|
Subcutaneous Tissue, Head, Granuloma | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 50 |
Cranium, Osteopetrosis | | 1 4.0|
Femur, Osteopetrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 50 |
Compression | | 6 |
Hemorrhage | 1 | 6 1.8|
Hydrocephalus | | 2 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 50 |
Congestion | 1 2 | 5 2.6|
Hemorrhage | | 7 1.7|
Infiltration Cellular | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 4| 7| 5| 4| 7| 4| 7| 4| 7| 7| | |
DAY ON TEST | 1| 3| 4| 5| 3| 5| 3| 5| 3| 3| | |
| 4| 1| 0| 8| 0| 9| 2| 9| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 | 49 2.0|
Metaplasia, Osseous | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 2 | 20 1.6|
Arteriole, Mineralization | 2 2 2 | 30 1.9|
Interstitium, Inflammation, Chronic | 2 | 9 1.1|
Interstitium, Inflammation, Chronic | | |
Active | | 2 1.5|
Peribronchiolar, Inflammation, Acute | | 1 1.0|
Peribronchiolar, Inflammation, | | |
Chronic | 1 | 5 1.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + | 50 |
Lumen, Foreign Body | | 1 2.0|
Lumen, Hemorrhage | 2 2 2 4 | 34 2.1|
Mucosa, Inflammation, Acute | 2 1 2 2 2 | 41 2.1|
Mucosa, Inflammation | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 2 1.5|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 2.0|
Olfactory Epithelium, Degeneration | 2 3 3 2 2 3 | 48 2.3|
Olfactory Epithelium, Erosion | 2 2 2 | 11 1.9|
Olfactory Epithelium, Metaplasia | | 1 2.0|
Olfactory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
Respiratory Epithelium, Degeneration | 1 1 1 1 1 | 45 1.5|
Respiratory Epithelium, Erosion | | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 50 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Atrophy | | 1 4.0|
Cataract | | 2 3.0|
Hemorrhage | | 1 3.0|
Retina, Degeneration | | 3 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 4| 7| 5| 4| 7| 4| 7| 4| 7| 7| | |
DAY ON TEST | 1| 3| 4| 5| 3| 5| 3| 5| 3| 3| | |
| 4| 1| 0| 8| 0| 9| 2| 9| 3| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Sclera, Mineralization | | 2 2.5|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 50 |
Nephropathy, Chronic | 3 2 3 2 3 | 48 2.6|
Pelvis, Calculus Micro Observation | | |
Only | | 1 |
Renal Tubule, Hyperplasia | | 1 1.0|
Renal Tubule, Hypertrophy | | 1 2.0|
Renal Tubule, Pigmentation | 1 2 2 2 2 2 2 | 50 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 1| 4| 4| 6| 7| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 3| 6| 9| 6| 5| 5| 4| 3| 3| 3| 4| 3| 5| 4| 3| 0| 2| 0| 5| 3| 3| 3| 3|
| 9| 3| 1| 3| 3| 5| 8| 8| 0| 0| 3| 0| 8| 2| 8| 8| 1| 6| 9| 8| 8| 0| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + M + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + M + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small | + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + M + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 2 |
Developmental Malformation | X X |
Fatty Change | 1 2 |
Focal Cellular Change | 1 X X X X X X X X X X X X X X X|
Granuloma | 2 2 2 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Bile Duct, Hyperplasia | 2 1 1 1 2 1 1 2 2 2 2|
Portal, Hyperplasia | 2 |
Portal, Inflammation, Chronic | 2 2 2 1 1 1 1 2 2 2 1 1 2 2 2|
Portal, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic Active | |
Acinus, Atrophy | 1 2 2 2 2 2|
Acinus, Vacuolization Cytoplasmic | 2 |
Arteriole, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2|
Acinus, Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
Inflammation, Chronic Active | 3 2 |
Ulcer | 3 3 4 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 2 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 1| 4| 4| 6| 7| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 3| 6| 9| 6| 5| 5| 4| 3| 3| 3| 4| 3| 5| 4| 3| 0| 2| 0| 5| 3| 3| 3| 3|
| 9| 3| 1| 3| 3| 5| 8| 8| 0| 0| 3| 0| 8| 2| 8| 8| 1| 6| 9| 8| 8| 0| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Dilatation | 2 2 1 2 2 2 2 2 1 2 1 |
Mucosa, Erosion | 3 1 |
Mucosa, Mineralization | 2 |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Chronic | |
Pulp, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 2 1 3 2 2 3 2 2 2 2 2 1 3 3 3 2 2 2|
Mineralization | 4 |
Artery, Mineralization | 4 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + M + + + + + + + + + +|
Congestion | 3 |
Degeneration, Fatty | 1 2 1 3 2 2 2 2 2 1 3 2 2 1 2|
Hyperplasia | 2 2 1 2 1 1 |
Hypertrophy | 2 |
Inflammation, Chronic | |
Pigmentation | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + M|
Hypertrophy | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Congestion | 2 |
Pars Distalis, Cyst | X X X X X|
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 3 2 2|
Pars Intermedia, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 2 2 1 1 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 1| 4| 4| 6| 7| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 3| 6| 9| 6| 5| 5| 4| 3| 3| 3| 4| 3| 5| 4| 3| 0| 2| 0| 5| 3| 3| 3| 3|
| 9| 3| 1| 3| 3| 5| 8| 8| 0| 0| 3| 0| 8| 2| 8| 8| 1| 6| 9| 8| 8| 0| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Acute | 4 |
Inflammation, Chronic | 1 2 2 2 1 2 2 2 2 2 1 1 2|
Inflammation, Chronic Active | 2 3 |
Duct, Ectasia | 4 |
Duct, Hyperplasia, Squamous | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Endometrium, Ectasia | |
Endometrium, Hyperplasia, Cystic | 2 1 |
Endometrium, Inflammation, Chronic | 2 |
Myometrium, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Vagina | + + |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | 2 2 2 3 |
Inflammation, Acute | 4 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Pigmentation | 2 |
Mesenteric, Congestion | 2 2 2|
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + M + + + + + + + M + + + + + +|
Congestion | 2 2|
Cyst | X X |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2|
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 |
Hematopoietic Cell Proliferation | 3 2 2 2 2 2 3 2 1 3 2 2 1 3 2 3 1|
Hyperplasia, Lymphoid | |
Infarct | |
Pigmentation | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 3 3 3|
Capsule, Inflammation, Acute | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 1| 4| 4| 6| 7| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 3| 6| 9| 6| 5| 5| 4| 3| 3| 3| 4| 3| 5| 4| 3| 0| 2| 0| 5| 3| 3| 3| 3|
| 9| 3| 1| 3| 3| 5| 8| 8| 0| 0| 3| 0| 8| 2| 8| 8| 1| 6| 9| 8| 8| 0| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | 2 |
Cyst | X X X |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Ectasia | 3 4 2 3 4 2 3 4 3 3 2 2|
Acinus, Hyperplasia, Cystic | |
Duct, Ectasia | 4 2 2 2 2 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Head, Ulcer | 3 |
Subcutaneous Tissue, Abscess | 4 |
Subcutaneous Tissue, Head, Abscess | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | 4 |
Femur, Fibrous Osteodystrophy | 4 X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X X X |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 3 |
Hemorrhage | 1 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Pigmentation, Cholesterol | 1 |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 2 2 1 1 1 2 2 2 2 1 2 |
Arteriole, Mineralization | 2 2 2 2 2 2 2 2 2 2|
Interstitium, Inflammation, Chronic | |
Interstitium, Inflammation, Chronic | |
Active | 2 2 |
Peribronchiolar, Inflammation, | |
Chronic | 2 |
Peribronchiolar, Inflammation, | |
Chronic Active | |
Pleura, Fibrosis | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 6| 7| 5| 6| 1| 4| 4| 6| 7| 7| 7| 6| 7| 4| 6| 7| 6| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 3| 6| 9| 6| 5| 5| 4| 3| 3| 3| 4| 3| 5| 4| 3| 0| 2| 0| 5| 3| 3| 3| 3|
| 9| 3| 1| 3| 3| 5| 8| 8| 0| 0| 3| 0| 8| 2| 8| 8| 1| 6| 9| 8| 8| 0| 0| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Smooth Muscle, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Glands, Hyperplasia | |
Lumen, Foreign Body | |
Lumen, Hemorrhage | 2 2 1 3 2 3 1 2 3 2 2 3 2|
Mucosa, Inflammation, Acute | 2 2 2 1 3 3 1 3 3 3 1 1 2 2 2|
Nasolacrimal Duct, Inflammation, | |
Acute | 2 2 |
Olfactory Epithelium, Degeneration | 2 2 3 2 2 2 2 2 2 2 2 3 2 2 2 3 3 3 2|
Olfactory Epithelium, Erosion | 2 2 2 1 2 2 |
Olfactory Epithelium, Hemorrhage | |
Olfactory Epithelium, Metaplasia | 2 |
Olfactory Epithelium, Metaplasia, | |
Squamous | 2 |
Respiratory Epithelium, Degeneration | 1 2 1 1 1 2 2 2 2 3 1 1 1 3 2 2|
Respiratory Epithelium, Erosion | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 |
Anterior Chamber, Hemorrhage | 3 |
Lids, Inflammation, Chronic Active | 2 |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy, Chronic | 1 3 4 2 4 2 2 3 3 2 4 4 3 2 4 4 4 2 2 3|
Capsule, Inflammation, Chronic | |
Renal Tubule, Cyst | |
Renal Tubule, Pigmentation | 1 2 2 2 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 5| 4| 5| 4| 7| 5| 4| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 6| 5| 3| 8| 5| 2| 3| 2| 3| 3| 3| 5| 3| 5| 6| 5| 2| 3| 2| 0| 0| 3| 3|
| 1| 9| 4| 8| 3| 4| 9| 3| 2| 1| 0| 1| 2| 9| 3| 2| 7| 9| 9| 2| 9| 6| 6| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Developmental Malformation | X X |
Fatty Change | |
Focal Cellular Change | X X X X X X X X X X X X X X X X X X|
Granuloma | 2 2 1 2 2 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 3|
Bile Duct, Hyperplasia | 2 2 2 2 3 2 2 2 2 1 2 1 2 2 1|
Portal, Hyperplasia | |
Portal, Inflammation, Chronic | 1 2 1 1 2 3 2 1 1 2 2 2 2 2 1 2 2 1|
Portal, Inflammation, Chronic Active | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic Active | |
Acinus, Atrophy | 1 2 2 2 2 2 2 |
Acinus, Vacuolization Cytoplasmic | |
Arteriole, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 4 |
Inflammation, Chronic Active | 3 |
Ulcer | 4 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Acute | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 5| 4| 5| 4| 7| 5| 4| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 6| 5| 3| 8| 5| 2| 3| 2| 3| 3| 3| 5| 3| 5| 6| 5| 2| 3| 2| 0| 0| 3| 3|
| 1| 9| 4| 8| 3| 4| 9| 3| 2| 1| 0| 1| 2| 9| 3| 2| 7| 9| 9| 2| 9| 6| 6| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Dilatation | 2 2 2 2 2 2 2 2 2 2 2 2 2 1|
Mucosa, Erosion | 1 |
Mucosa, Mineralization | |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Chronic | |
Pulp, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 2 2 2 2 2 3 2 2 2 1 2 2 3 2 3 2 1|
Mineralization | |
Artery, Mineralization | |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Degeneration, Fatty | 1 1 1 2 3 1 2 1 4 2 1 1 2 1|
Hyperplasia | 1 2 1|
Hypertrophy | 2 1 |
Inflammation, Chronic | 2 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M M + M + + M M + + + + + +|
Hypertrophy | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Congestion | |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 3 2 3 |
Pars Intermedia, Angiectasis | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X X |
C-Cell, Hyperplasia | 2 1 1 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 5| 4| 5| 4| 7| 5| 4| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 6| 5| 3| 8| 5| 2| 3| 2| 3| 3| 3| 5| 3| 5| 6| 5| 2| 3| 2| 0| 0| 3| 3|
| 1| 9| 4| 8| 3| 4| 9| 3| 2| 1| 0| 1| 2| 9| 3| 2| 7| 9| 9| 2| 9| 6| 6| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M M + + + + M M + + + + + + + + + M + +|
Hyperplasia | |
Inflammation, Acute | 4 |
Inflammation, Chronic | 1 1 1 2 1 2 |
Inflammation, Chronic Active | 2 2 1 |
Duct, Ectasia | |
Duct, Hyperplasia, Squamous | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Endometrium, Ectasia | 2 |
Endometrium, Hyperplasia, Cystic | 2 4 1 2 |
Endometrium, Inflammation, Chronic | |
Myometrium, Inflammation, Chronic | |
__________________________________________________________________________|
Vagina | + |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Myelofibrosis | 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 2 2 2|
Inflammation, Acute | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Pigmentation | |
Mesenteric, Congestion | 2 |
Mesenteric, Hyperplasia, Lymphoid | 2 1 2 2 3 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | M M + M + + + + + + + M + + + + + + + +|
Congestion | 2|
Cyst | |
Hyperplasia, Lymphoid | 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2|
Inflammation, Acute | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 3 2 2 2 2 2 2 2 2 4 1 2 3 1 2 2 2 2 2|
Hyperplasia, Lymphoid | 2 |
Infarct | 3 |
Pigmentation | 2 2 2 2 2 2 2 2 2 1 4 2 1 2 2 2 2 2 2 2|
Capsule, Inflammation, Acute | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + M M +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 5| 4| 5| 4| 7| 5| 4| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 6| 5| 3| 8| 5| 2| 3| 2| 3| 3| 3| 5| 3| 5| 6| 5| 2| 3| 2| 0| 0| 3| 3|
| 1| 9| 4| 8| 3| 4| 9| 3| 2| 1| 0| 1| 2| 9| 3| 2| 7| 9| 9| 2| 9| 6| 6| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | |
Cyst | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Ectasia | 4 2 3 2 3 3 2 4 2 2 2 2|
Acinus, Hyperplasia, Cystic | |
Duct, Ectasia | 3 3 2 2 3 2 4 3 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Head, Ulcer | |
Subcutaneous Tissue, Abscess | |
Subcutaneous Tissue, Head, Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X |
Femur, Fibrous Osteodystrophy | 2 X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Compression | X X X X |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2|
Hemorrhage | 3 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2|
Pigmentation, Cholesterol | 2 |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 2 2 1 1 2 2 3 1 1 1 1 2 2|
Arteriole, Mineralization | 2 2 2 2 1 2 2 2 2 2 2 2 1|
Interstitium, Inflammation, Chronic | 1 |
Interstitium, Inflammation, Chronic | |
Active | 1 1 |
Peribronchiolar, Inflammation, | |
Chronic | |
Peribronchiolar, Inflammation, | |
Chronic Active | 4 |
Pleura, Fibrosis | 4 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 5| 4| 5| 4| 7| 5| 4| 7| 7| 4| 7| 7| 7| 4| 7| 6| 6| 4| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 6| 5| 3| 8| 5| 2| 3| 2| 3| 3| 3| 5| 3| 5| 6| 5| 2| 3| 2| 0| 0| 3| 3|
| 1| 9| 4| 8| 3| 4| 9| 3| 2| 1| 0| 1| 2| 9| 3| 2| 7| 9| 9| 2| 9| 6| 6| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Smooth Muscle, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Glands, Hyperplasia | 4 |
Lumen, Foreign Body | 2 |
Lumen, Hemorrhage | 2 3 2 2 2 2 2 3 2 1 2 2|
Mucosa, Inflammation, Acute | 1 2 2 2 2 2 2 2 3 2 2 2 2 2 2 1 2 2|
Nasolacrimal Duct, Inflammation, | |
Acute | 3 2 |
Olfactory Epithelium, Degeneration | 1 2 2 2 2 2 2 2 2 2 2 2 2 3 3 2 2 3 2|
Olfactory Epithelium, Erosion | 1 |
Olfactory Epithelium, Hemorrhage | |
Olfactory Epithelium, Metaplasia | 2 2 |
Olfactory Epithelium, Metaplasia, | |
Squamous | |
Respiratory Epithelium, Degeneration | 1 1 1 1 1 1 1 1 2 1 3 2 2 2 1|
Respiratory Epithelium, Erosion | 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Anterior Chamber, Hemorrhage | |
Lids, Inflammation, Chronic Active | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy, Chronic | 1 4 2 2 2 2 1 3 3 2 3 3 4 4 4 2 3 2 2 1|
Capsule, Inflammation, Chronic | |
Renal Tubule, Cyst | X |
Renal Tubule, Pigmentation | 1 2 2 1 2 2 1 2 1 2 2 2 1 1 2 2 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 5| 5| 3| 3| 2| 3| 3| 2| 3| 3| | |
| 9| 4| 3| 2| 9| 0| 3| 9| 3| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 49 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 48 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 49 |
Erosion | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Angiectasis | 2 2 1 | 6 1.7|
Developmental Malformation | X | 5 |
Fatty Change | | 2 1.5|
Focal Cellular Change | X X X X X X X | 41 1.0|
Granuloma | 2 2 | 10 1.9|
Hematopoietic Cell Proliferation | | 2 2.0|
Hemorrhage | | 1 3.0|
Bile Duct, Hyperplasia | 1 2 2 2 2 | 31 1.7|
Portal, Hyperplasia | | 1 2.0|
Portal, Inflammation, Chronic | 1 1 2 1 2 2 2 | 40 1.6|
Portal, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Acinus, Atrophy | 2 2 | 15 1.9|
Acinus, Vacuolization Cytoplasmic | | 1 2.0|
Arteriole, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
Hyperplasia, Squamous | 3 3 | 4 3.3|
Inflammation, Chronic Active | | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 5| 5| 3| 3| 2| 3| 3| 2| 3| 3| | |
| 9| 4| 3| 2| 9| 0| 3| 9| 3| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 4 | 9 3.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 50 |
Foreign Body | 3 | 1 3.0|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | | 2 2.0|
Mucosa, Dilatation | 2 2 2 | 28 1.9|
Mucosa, Erosion | 2 2 | 5 1.8|
Mucosa, Mineralization | | 1 2.0|
Serosa, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Peridontal Tissue, Inflammation, | | |
Chronic | 3 | 1 3.0|
Pulp, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + | 50 |
Aorta, Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Cardiomyopathy, Chronic | 2 2 3 2 2 3 2 2 1 | 47 2.0|
Mineralization | | 1 4.0|
Artery, Mineralization | | 1 4.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 49 |
Congestion | | 1 3.0|
Degeneration, Fatty | 2 2 2 3 1 2 3 1 | 37 1.8|
Hyperplasia | | 9 1.4|
Hypertrophy | 2 | 4 1.8|
Inflammation, Chronic | | 1 2.0|
Pigmentation | 2 2 2 2 2 2 2 2 2 | 48 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 49 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 1 | 6 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + + + + | 41 |
Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 5| 5| 3| 3| 2| 3| 3| 2| 3| 3| | |
| 9| 4| 3| 2| 9| 0| 3| 9| 3| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Congestion | | 1 2.0|
Pars Distalis, Cyst | X X | 11 |
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 2 | 7 2.4|
Pars Intermedia, Angiectasis | 2 | 2 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
Ultimobranchial Cyst | | 2 |
C-Cell, Hyperplasia | 2 | 15 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + | 44 |
Hyperplasia | 3 | 2 3.0|
Inflammation, Acute | | 2 4.0|
Inflammation, Chronic | 1 2 | 21 1.6|
Inflammation, Chronic Active | 2 1 | 7 1.9|
Duct, Ectasia | | 1 4.0|
Duct, Hyperplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 50 |
Follicle, Cyst | | 1 |
Periovarian Tissue, Cyst | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 50 |
Ectasia | 2 | 1 2.0|
Endometrium, Ectasia | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 1 | 7 1.9|
Endometrium, Inflammation, Chronic | | 1 2.0|
Myometrium, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | | 3 |
Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Hyperplasia | | 1 4.0|
Myelofibrosis | 1 | 4 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 50 |
Congestion | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 5| 5| 3| 3| 2| 3| 3| 2| 3| 3| | |
| 9| 4| 3| 2| 9| 0| 3| 9| 3| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 2 2 | 10 2.1|
Inflammation, Acute | | 1 4.0|
Mediastinal, Hyperplasia, Lymphoid | | 2 2.0|
Mediastinal, Pigmentation | | 1 2.0|
Mesenteric, Congestion | | 4 2.0|
Mesenteric, Hyperplasia, Lymphoid | 1 2 2 | 29 1.9|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + | 42 |
Congestion | | 3 2.0|
Cyst | | 2 |
Hyperplasia, Lymphoid | 2 2 3 2 2 2 2 | 39 1.9|
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Fibrosis | | 3 2.7|
Hematopoietic Cell Proliferation | 2 2 2 3 2 2 1 2 | 44 2.1|
Hyperplasia, Lymphoid | | 1 2.0|
Infarct | | 1 3.0|
Pigmentation | 2 2 1 4 1 2 1 2 | 47 2.0|
Capsule, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + | 46 |
Congestion | | 1 2.0|
Cyst | | 3 |
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 50 |
Inflammation, Chronic | 3 | 1 3.0|
Acinus, Ectasia | 2 4 2 | 27 2.7|
Acinus, Hyperplasia, Cystic | 4 | 1 4.0|
Duct, Ectasia | 2 1 3 2 | 23 2.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Cyst Epithelial Inclusion | | 1 |
Head, Ulcer | | 1 3.0|
Subcutaneous Tissue, Abscess | | 1 4.0|
Subcutaneous Tissue, Head, Abscess | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
Cranium, Fibrous Osteodystrophy | | 2 4.0|
Femur, Fibrous Osteodystrophy | | 4 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 5| 5| 3| 3| 2| 3| 3| 2| 3| 3| | |
| 9| 4| 3| 2| 9| 0| 3| 9| 3| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 49 |
Compression | X X | 13 |
Hemorrhage | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Congestion | 1 | 6 2.2|
Hemorrhage | 1 | 4 1.8|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 | 50 2.0|
Pigmentation, Cholesterol | | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 2 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 1 2 1 2 | 36 1.6|
Arteriole, Mineralization | 2 2 2 | 26 1.9|
Interstitium, Inflammation, Chronic | 1 | 2 1.0|
Interstitium, Inflammation, Chronic | | |
Active | | 4 1.5|
Peribronchiolar, Inflammation, | | |
Chronic | | 1 2.0|
Peribronchiolar, Inflammation, | | |
Chronic Active | | 1 4.0|
Pleura, Fibrosis | | 1 4.0|
Smooth Muscle, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 50 |
Glands, Hyperplasia | | 1 4.0|
Lumen, Foreign Body | | 1 2.0|
Lumen, Hemorrhage | 2 3 2 1 2 2 2 | 32 2.1|
Mucosa, Inflammation, Acute | 1 2 2 2 2 2 2 2 | 41 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | 2 1 | 6 2.0|
Olfactory Epithelium, Degeneration | 2 3 2 2 2 2 2 2 2 | 47 2.2|
Olfactory Epithelium, Erosion | 1 2 2 | 10 1.7|
Olfactory Epithelium, Hemorrhage | 2 | 1 2.0|
Olfactory Epithelium, Metaplasia | 2 1 | 5 1.8|
Olfactory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
Respiratory Epithelium, Degeneration | 2 1 1 1 1 3 2 1 | 39 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 5| 5| 3| 3| 2| 3| 3| 2| 3| 3| | |
| 9| 4| 3| 2| 9| 0| 3| 9| 3| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Erosion | | 3 2.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | 2 | 2 2.5|
Anterior Chamber, Hemorrhage | | 1 3.0|
Lids, Inflammation, Chronic Active | | 1 2.0|
Retina, Degeneration | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Hydronephrosis | 4 | 1 4.0|
Nephropathy, Chronic | 2 3 3 4 3 4 3 2 4 | 49 2.8|
Capsule, Inflammation, Chronic | 2 | 1 2.0|
Renal Tubule, Cyst | | 1 |
Renal Tubule, Pigmentation | 2 2 2 1 2 2 2 2 1 | 48 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 5| 6| 7| 7| 6| 7| 4| 7| 4| 7|
DAY ON TEST | 5| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 3| 3| 8| 5| 3| 3| 2| 3| 5| 3| 7| 2|
| 9| 0| 9| 0| 3| 0| 2| 2| 3| 5| 3| 1| 1| 8| 1| 9| 2| 3| 1| 5| 0| 9| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + M + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 |
Congestion | |
Developmental Malformation | X |
Fatty Change | 2 |
Focal Cellular Change | X X X X X X X X X X X X|
Granuloma | |
Necrosis | 3 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 2 2|
Portal, Inflammation, Chronic | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 2 2 2 2 2 3 2 2 2 1 3|
Acinus, Hyperplasia | |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Erosion | 3 |
Hyperplasia, Squamous | 2 2 |
Inflammation, Acute | 2 3 |
Inflammation, Chronic Active | 2 3 |
Ulcer | 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Mucosa, Dilatation | 2 2 2 1 2 1 2 2 |
Mucosa, Ectasia | 2 2 |
Mucosa, Erosion | 2 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 5| 6| 7| 7| 6| 7| 4| 7| 4| 7|
DAY ON TEST | 5| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 3| 3| 8| 5| 3| 3| 2| 3| 5| 3| 7| 2|
| 9| 0| 9| 0| 3| 0| 2| 2| 3| 5| 3| 1| 1| 8| 1| 9| 2| 3| 1| 5| 0| 9| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Ulcer | 4 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 2 2 3 2 3 2 2 2 3 2 2 3 3 3 1 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 2 2 2 2 2 2 2 2 2 3 2 1 2 3 2 |
Hyperplasia | 2 1 1 2 1 2 2 2 2 |
Hypertrophy | 1 2 2 |
Pigmentation | 2 1 1 1 1 1 2 1 1 2 1 2 2 1 1 2 1 2 2 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M M + + + M + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Atrophy | |
Pars Distalis, Cyst | X |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 2 2 1 2 3 1 2 2 2 3 |
Pars Intermedia, Cyst | X X |
Pars Nervosa, Pigmentation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 2 2 3 1 1 3 2|
Follicle, Ectasia | 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 3 4 |
Inflammation, Acute | 4 |
Inflammation, Chronic | 2 2 2 1 2 1 2 2 2 2 2 2|
Inflammation, Chronic Active | 3 2 |
Duct, Ectasia | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 5| 6| 7| 7| 6| 7| 4| 7| 4| 7|
DAY ON TEST | 5| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 3| 3| 8| 5| 3| 3| 2| 3| 5| 3| 7| 2|
| 9| 0| 9| 0| 3| 0| 2| 2| 3| 5| 3| 1| 1| 8| 1| 9| 2| 3| 1| 5| 0| 9| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia | 2 2 2 |
Inflammation, Acute | 3 4 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 2 1 2 3 2 3|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 2 |
Interstitial Cell, Hyperplasia | 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hyperplasia, Lymphoid | |
Mediastinal, Congestion | 2 |
Mesenteric, Congestion | 1 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 1 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + M + M M + + M + + M +|
Congestion | 2 2 3 3 2 2 |
Cyst | X |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 2 2 3 2 2 2 2 2 2 2 2 3 3 2 2 3 2 2 2 2 2|
Hyperplasia, Lymphoid | 2 |
Mineralization | |
Pigmentation | 2 2 2 3 2 2 2 2 2 2 2 2 3 2 2 2 2 2 1 2 2|
__________________________________________________________________________|
Thymus | + + M + M + + + + + + + + + + M + + + + + + +|
Congestion | 3 |
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic | |
Acinus, Ectasia | 2 2 2 1 2 3 4 2 2 2 2 1 3 2|
Duct, Ectasia | 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Epidermis, Cyst | 3 |
Hair Follicle, Head, Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 5| 6| 7| 7| 6| 7| 4| 7| 4| 7|
DAY ON TEST | 5| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 3| 3| 8| 5| 3| 3| 2| 3| 5| 3| 7| 2|
| 9| 0| 9| 0| 3| 0| 2| 2| 3| 5| 3| 1| 1| 8| 1| 9| 2| 3| 1| 5| 0| 9| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hair Follicle, Head, Inflammation, | |
Acute | 2 |
Head, Inflammation, Acute | |
Head, Inflammation, Chronic Active | |
Tail, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | 3 |
Femur, Fibrous Osteodystrophy | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hemorrhage | 3 3 2 2 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Hemorrhage | 3 1 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2|
Pigmentation, Cholesterol | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 2 2 2 2 2 2 2 1 1 1 2 1 1|
Arteriole, Mineralization | 2 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2|
Bronchiole, Mineralization | 1 |
Interstitium, Inflammation, Chronic | 2 2 1 |
Interstitium, Inflammation, Chronic | |
Active | 1 1 1 |
Pleura, Inflammation, Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Lumen, Foreign Body | |
Lumen, Hemorrhage | 3 3 2 2 2 2 2 2 2 3 3 4 2 2 4 2 2 3|
Mucosa, Inflammation, Acute | 2 2 2 1 1 2 2 1 2 2 2 2|
Mucosa, Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Acute | 1 3 2 |
Nasolacrimal Duct, Inflammation | 2 |
Nasopharyngeal Duct, Inflammation, | |
Acute | 2 |
Olfactory Epithelium, Degeneration | 2 2 2 2 1 1 2 2 2 1 2 2 2 2 2 2 2 1|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 3| 7| 5| 6| 7| 7| 6| 7| 4| 7| 4| 7|
DAY ON TEST | 5| 3| 2| 3| 3| 3| 3| 3| 3| 4| 3| 3| 0| 3| 3| 8| 5| 3| 3| 2| 3| 5| 3| 7| 2|
| 9| 0| 9| 0| 3| 0| 2| 2| 3| 5| 3| 1| 1| 8| 1| 9| 2| 3| 1| 5| 0| 9| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Degeneration | 2 2 2 1 1 3 1 2 1 2 |
Respiratory Epithelium, Erosion | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
Vomeronasal Organ, Inflammation, | |
Acute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
Retina, Degeneration | 4 |
Sclera, Mineralization | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Nephropathy, Chronic | 3 3 2 2 2 4 2 2 2 3 2 4 2 4 2 3 2 4 2 4 3 3|
Renal Tubule, Cyst | |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Pigmentation | 2 2 2 1 2 2 2 2 2 2 2 2 1 1 2 2 1 2 2 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Hemorrhage | |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 4| 6| 4| 7| 7| 4| 6| 6| 7| 6| 4| 6| 7| 6| 7| 4| 6| 7| 7| 4| 7| 6| 6| 6| 4|
DAY ON TEST | 5| 3| 5| 3| 3| 7| 1| 6| 3| 7| 5| 2| 3| 7| 2| 5| 2| 3| 3| 5| 3| 1| 0| 7| 5|
| 9| 1| 8| 2| 2| 2| 4| 3| 2| 3| 8| 5| 2| 2| 9| 9| 2| 1| 3| 8| 0| 8| 2| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 2 3 |
Congestion | 3 3 2 |
Developmental Malformation | |
Fatty Change | 3 |
Focal Cellular Change | X X X X X X X X X X |
Granuloma | 2 |
Necrosis | 2 |
Bile Duct, Hyperplasia | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 3 1 2 4 |
Portal, Inflammation, Chronic | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 1 2 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + |
Acinus, Atrophy | 2 4 4 4 4 3 4 3 2 2 1 1 3 |
Acinus, Hyperplasia | |
Artery, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + |
Cyst | X |
Erosion | |
Hyperplasia, Squamous | |
Inflammation, Acute | 3 2 |
Inflammation, Chronic Active | 3 |
Ulcer | 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Mucosa, Dilatation | 2 2 2 2 1 |
Mucosa, Ectasia | |
Mucosa, Erosion | 1 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 4| 6| 4| 7| 7| 4| 6| 6| 7| 6| 4| 6| 7| 6| 7| 4| 6| 7| 7| 4| 7| 6| 6| 6| 4|
DAY ON TEST | 5| 3| 5| 3| 3| 7| 1| 6| 3| 7| 5| 2| 3| 7| 2| 5| 2| 3| 3| 5| 3| 1| 0| 7| 5|
| 9| 1| 8| 2| 2| 2| 4| 3| 2| 3| 8| 5| 2| 2| 9| 9| 2| 1| 3| 8| 0| 8| 2| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy, Chronic | 2 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 4 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Degeneration, Fatty | 2 2 2 1 2 2 2 2 2 1 2 2 3 2 |
Hyperplasia | 2 2 2 |
Hypertrophy | |
Pigmentation | 2 1 2 2 2 2 1 2 2 2 2 1 1 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M + + M + + + + + + M + |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Atrophy | 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 2 2 3 2 |
Pars Intermedia, Cyst | |
Pars Nervosa, Pigmentation | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 2 1 |
Follicle, Ectasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + |
Abscess | |
Inflammation, Acute | |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Inflammation, Chronic Active | 2 2 2 3 |
Duct, Ectasia | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 4| 6| 4| 7| 7| 4| 6| 6| 7| 6| 4| 6| 7| 6| 7| 4| 6| 7| 7| 4| 7| 6| 6| 6| 4|
DAY ON TEST | 5| 3| 5| 3| 3| 7| 1| 6| 3| 7| 5| 2| 3| 7| 2| 5| 2| 3| 3| 5| 3| 1| 0| 7| 5|
| 9| 1| 8| 2| 2| 2| 4| 3| 2| 3| 8| 5| 2| 2| 9| 9| 2| 1| 3| 8| 0| 8| 2| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + |
Atrophy | |
Hyperplasia | 2 2 2 3 |
Inflammation, Acute | 2 2 |
Inflammation, Chronic | 4 |
Inflammation, Chronic Active | 3 3 3 3 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + |
Atrophy | 2 3 1 3 2 3 |
Interstitial Cell, Hyperplasia | 2 2 2 1 2 2 2 1 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + |
Edema | |
Hyperplasia, Lymphoid | 2 |
Mediastinal, Congestion | |
Mesenteric, Congestion | |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 1 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + M + + M + M + + + M + + + M M + |
Congestion | 2 2 2 |
Cyst | |
Hyperplasia, Lymphoid | 2 2 1 2 3 2 2 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
Fibrosis | 3 3 |
Hematopoietic Cell Proliferation | 2 2 1 2 2 3 3 2 2 2 2 2 2 2 2 |
Hyperplasia, Lymphoid | 2 |
Mineralization | 2 |
Pigmentation | 2 2 2 3 2 2 2 2 2 2 2 2 2 1 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + M + + + + + + + + |
Congestion | 2 |
Cyst | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 2 |
Inflammation, Chronic | |
Acinus, Ectasia | 2 3 4 4 3 3 2 2 2 2 2 2 2 3 2 |
Duct, Ectasia | 1 2 3 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
Cyst Epithelial Inclusion | |
Epidermis, Cyst | |
Hair Follicle, Head, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 4| 6| 4| 7| 7| 4| 6| 6| 7| 6| 4| 6| 7| 6| 7| 4| 6| 7| 7| 4| 7| 6| 6| 6| 4|
DAY ON TEST | 5| 3| 5| 3| 3| 7| 1| 6| 3| 7| 5| 2| 3| 7| 2| 5| 2| 3| 3| 5| 3| 1| 0| 7| 5|
| 9| 1| 8| 2| 2| 2| 4| 3| 2| 3| 8| 5| 2| 2| 9| 9| 2| 1| 3| 8| 0| 8| 2| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hair Follicle, Head, Inflammation, | |
Acute | |
Head, Inflammation, Acute | |
Head, Inflammation, Chronic Active | |
Tail, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
Cranium, Fibrous Osteodystrophy | |
Femur, Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Compression | X X X X |
Hemorrhage | 4 2 2 3 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Congestion | 3 4 3 2 |
Hemorrhage | 2 1 3 1 2 1 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Pigmentation, Cholesterol | |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 2 2 2 1 |
Arteriole, Mineralization | 2 2 2 2 2 1 2 2 1 2 2 2 2 1 2 |
Bronchiole, Mineralization | |
Interstitium, Inflammation, Chronic | 1 |
Interstitium, Inflammation, Chronic | |
Active | 1 1 |
Pleura, Inflammation, Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 |
Lumen, Foreign Body | 2 2 2 |
Lumen, Hemorrhage | 1 2 2 2 2 2 1 2 3 2 1 |
Mucosa, Inflammation, Acute | 2 1 1 2 2 1 3 2 2 2 2 1 |
Mucosa, Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Nasolacrimal Duct, Inflammation | |
Nasopharyngeal Duct, Inflammation, | |
Acute | |
Olfactory Epithelium, Degeneration | 1 2 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 4| 6| 4| 7| 7| 4| 6| 6| 7| 6| 4| 6| 7| 6| 7| 4| 6| 7| 7| 4| 7| 6| 6| 6| 4|
DAY ON TEST | 5| 3| 5| 3| 3| 7| 1| 6| 3| 7| 5| 2| 3| 7| 2| 5| 2| 3| 3| 5| 3| 1| 0| 7| 5|
| 9| 1| 8| 2| 2| 2| 4| 3| 2| 3| 8| 5| 2| 2| 9| 9| 2| 1| 3| 8| 0| 8| 2| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Degeneration | 1 2 1 |
Respiratory Epithelium, Erosion | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
Vomeronasal Organ, Inflammation, | |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
Retina, Degeneration | |
Sclera, Mineralization | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | |
Nephropathy, Chronic | 4 3 2 2 2 4 4 3 2 3 2 3 2 3 4 2 4 3 4 |
Renal Tubule, Cyst | X |
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Pigmentation | 2 2 2 1 2 1 2 2 3 2 2 2 1 2 2 2 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + |
Calculus Gross Observation | X |
Hemorrhage | 2 |
Inflammation, Acute | 3 |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2| | |
| 9| 7| 6| 8| 9| 1| 9| 1| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 50 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 50 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 49 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 50 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Angiectasis | 1 | 7 1.9|
Congestion | | 3 2.7|
Developmental Malformation | | 1 |
Fatty Change | 2 | 3 2.3|
Focal Cellular Change | X X X X X X | 28 |
Granuloma | | 1 2.0|
Necrosis | | 2 2.5|
Bile Duct, Hyperplasia | 2 2 2 4 3 1 1 2 | 48 2.1|
Portal, Inflammation, Chronic | 2 2 2 2 1 2 1 2 | 48 1.9|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | 3 | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Acinus, Atrophy | 2 2 3 2 | 30 2.4|
Acinus, Hyperplasia | 2 | 1 2.0|
Artery, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 50 |
Cyst | | 1 |
Erosion | | 1 3.0|
Hyperplasia, Squamous | | 2 2.0|
Inflammation, Acute | | 4 2.5|
Inflammation, Chronic Active | | 3 2.7|
Ulcer | | 4 3.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2| | |
| 9| 7| 6| 8| 9| 1| 9| 1| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 50 |
Inflammation, Acute | | 1 3.0|
Mucosa, Dilatation | 2 2 1 1 | 17 1.7|
Mucosa, Ectasia | | 2 2.0|
Mucosa, Erosion | 3 3 | 4 2.3|
Mucosa, Ulcer | | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Cardiomyopathy, Chronic | 3 2 3 3 3 2 3 | 49 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Degeneration, Fatty | 2 3 2 2 2 | 35 2.0|
Hyperplasia | 1 2 1 | 15 1.7|
Hypertrophy | 1 | 4 1.5|
Pigmentation | 1 2 1 1 2 2 1 | 43 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 49 |
Hyperplasia | 1 2 | 10 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + | 42 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 49 |
Pars Distalis, Atrophy | | 1 2.0|
Pars Distalis, Cyst | X | 3 |
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 1 2 2 | 18 2.0|
Pars Intermedia, Cyst | | 2 |
Pars Nervosa, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 1 | 12 1.7|
Follicle, Ectasia | | 3 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2| | |
| 9| 7| 6| 8| 9| 1| 9| 1| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 50 |
Abscess | | 3 3.3|
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic | 2 2 2 2 | 29 1.9|
Inflammation, Chronic Active | 3 2 2 2 | 10 2.3|
Duct, Ectasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 50 |
Atrophy | | 1 2.0|
Hyperplasia | 2 2 2 | 10 2.1|
Inflammation, Acute | 2 3 | 7 2.6|
Inflammation, Chronic | | 1 4.0|
Inflammation, Chronic Active | 2 3 | 14 2.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 50 |
Atrophy | 1 | 11 2.2|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 | 35 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 4 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 50 |
Myelofibrosis | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
Edema | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Congestion | | 1 2.0|
Mesenteric, Congestion | | 1 1.0|
Mesenteric, Hyperplasia, Lymphoid | 2 2 | 17 1.9|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + | 36 |
Congestion | 3 | 10 2.3|
Cyst | | 1 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 1 | 32 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Fibrosis | 3 3 | 5 3.0|
Hematopoietic Cell Proliferation | 1 2 2 2 2 | 42 2.1|
Hyperplasia, Lymphoid | | 2 2.0|
Mineralization | | 1 2.0|
Pigmentation | 2 2 1 2 | 39 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + | 44 |
Congestion | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2| | |
| 9| 7| 6| 8| 9| 1| 9| 1| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cyst | | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 50 |
Inflammation, Acute | | 2 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Acinus, Ectasia | 3 3 2 3 2 | 34 2.4|
Duct, Ectasia | 3 | 10 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 50 |
Cyst Epithelial Inclusion | | 1 |
Epidermis, Cyst | | 1 3.0|
Hair Follicle, Head, Hemorrhage | | 1 2.0|
Hair Follicle, Head, Inflammation, | | |
Acute | | 1 2.0|
Head, Inflammation, Acute | 2 | 1 2.0|
Head, Inflammation, Chronic Active | 2 | 1 2.0|
Tail, Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
Cranium, Fibrous Osteodystrophy | | 1 3.0|
Femur, Fibrous Osteodystrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Compression | | 5 |
Hemorrhage | 3 1 | 11 2.5|
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Congestion | | 6 2.8|
Hemorrhage | | 8 1.8|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 | 50 2.0|
Pigmentation, Cholesterol | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 2 1 2 2 | 26 1.7|
Arteriole, Mineralization | 2 2 1 2 2 2 1 | 41 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2| | |
| 9| 7| 6| 8| 9| 1| 9| 1| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Bronchiole, Mineralization | | 1 1.0|
Interstitium, Inflammation, Chronic | 2 | 5 1.6|
Interstitium, Inflammation, Chronic | | |
Active | | 5 1.0|
Pleura, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
Inflammation, Chronic Active | | 1 2.0|
Lumen, Foreign Body | 2 | 4 2.0|
Lumen, Hemorrhage | 2 3 | 31 2.3|
Mucosa, Inflammation, Acute | 2 2 2 2 1 3 | 30 1.8|
Mucosa, Inflammation, Chronic Active | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 4 2.0|
Nasolacrimal Duct, Inflammation | | 1 2.0|
Nasopharyngeal Duct, Inflammation, | | |
Acute | | 1 2.0|
Olfactory Epithelium, Degeneration | 2 2 2 2 1 1 2 1 | 39 1.8|
Respiratory Epithelium, Degeneration | 2 2 | 15 1.7|
Respiratory Epithelium, Erosion | 2 2 | 4 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
Vomeronasal Organ, Inflammation, | | |
Acute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 1 4.0|
Retina, Degeneration | | 1 4.0|
Sclera, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Nephropathy, Chronic | 3 4 1 4 2 3 3 4 | 49 2.9|
Renal Tubule, Cyst | | 1 |
Renal Tubule, Hyperplasia | 2 4 | 4 2.0|
Renal Tubule, Pigmentation | 2 2 2 2 2 1 2 1 | 50 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 7| 1| 5| 5| 3| 2| 3| 3| 2| | |
| 9| 7| 6| 8| 9| 1| 9| 1| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 50 |
Calculus Gross Observation | | 1 |
Hemorrhage | | 1 2.0|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 6| 2| 6| 7| 6| 7| 4| 7| 6| 7| 7| 4| 4| 7| 6| 6| 7| 7| 5| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 8| 8| 2| 3| 8| 3| 5| 3| 8| 3| 2| 5| 7| 3| 2| 1| 3| 3| 7| 9| 7| 3| 7| 1| 1|
| 1| 3| 5| 1| 9| 0| 8| 2| 8| 3| 9| 9| 8| 0| 4| 8| 3| 1| 2| 8| 0| 2| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hemorrhage | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Parasite Metazoan | X X|
Ulcer | 4 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Congestion | 3 |
Developmental Malformation | X X X |
Fatty Change | 4 |
Focal Cellular Change | X X X X X X X X X X X|
Granuloma | 2 |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | 2 |
Necrosis | 3 |
Bile Duct, Dilatation | |
Bile Duct, Hyperplasia | 2 3 2 4 2 2 2 2 2 2 2 2 3 2 2 2 2 2 3 2 2 2|
Bile Duct, Inflammation, Chronic | |
Portal, Inflammation, Chronic | 2 2 3 2 2 1 2 2 1 2 3 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | |
Inflammation, Acute | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Acinus, Atrophy | 2 2 2 2 2 3 2 2 4 4 2 3 3 2 1 |
Acinus, Hyperplasia | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia, Squamous | |
Inflammation, Acute | 4 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 6| 2| 6| 7| 6| 7| 4| 7| 6| 7| 7| 4| 4| 7| 6| 6| 7| 7| 5| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 8| 8| 2| 3| 8| 3| 5| 3| 8| 3| 2| 5| 7| 3| 2| 1| 3| 3| 7| 9| 7| 3| 7| 1| 1|
| 1| 3| 5| 1| 9| 0| 8| 2| 8| 3| 9| 9| 8| 0| 4| 8| 3| 1| 2| 8| 0| 2| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 4 |
Ulcer | 4 4 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Congestion | 2 |
Mucosa, Dilatation | 2 2 2 2 2 2 2 1 1 2 |
Mucosa, Erosion | 2 2 2 3 2 2 |
Mucosa, Granuloma | |
Mucosa, Hemorrhage | |
Mucosa, Inflammation, Acute | |
Mucosa, Ulcer | 4 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 3 2 2 2 3 2 2 3 2 2 3 2 2 2 3 3 3 3|
Hemorrhage | |
Atrium, Thrombosis | X X X |
Pericardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 4 2 2 2 2 2 2 2 1 2 2 2 1 2 2 2 1 1 2 1|
Hyperplasia | 2 2|
Hypertrophy | |
Pigmentation | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 3 3 3 2 3 2 2 2 2 |
Pars Intermedia, Angiectasis | 3 |
Pars Intermedia, Cyst | X |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 1 1 2 1 2 2 |
Follicle, Ectasia | 2 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 6| 2| 6| 7| 6| 7| 4| 7| 6| 7| 7| 4| 4| 7| 6| 6| 7| 7| 5| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 8| 8| 2| 3| 8| 3| 5| 3| 8| 3| 2| 5| 7| 3| 2| 1| 3| 3| 7| 9| 7| 3| 7| 1| 1|
| 1| 3| 5| 1| 9| 0| 8| 2| 8| 3| 9| 9| 8| 0| 4| 8| 3| 1| 2| 8| 0| 2| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic | 2 2 3 1 2 2 2 2 3 2 3 2 |
Inflammation, Chronic Active | 2 4 3 2 2 3 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
Inflammation, Acute | 2 2 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + |
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 2 4 4 2 4 |
Congestion | 2 |
Mineralization | 1 |
Arteriole, Inflammation, Chronic | |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Lymphoid | 2 2 |
Mediastinal, Congestion | 4 4 |
Mediastinal, Hyperplasia, Lymphoid | |
Mesenteric, Congestion | |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2|
Mesenteric, Inflammation, Acute | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + M + + + M + M + + + +|
Congestion | 2 2 2 2|
Cyst | X |
Hyperplasia, Lymphoid | 3 2 3 2 2 3 3 3 2 2 3 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 3 2 2 2 2 2 2 2 2 2 2 3 2 2 3 1 1 2 2|
Infarct | 4 |
Pigmentation | 2 3 2 2 2 1 2 2 2 1 1 3 2 2 1 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 6| 2| 6| 7| 6| 7| 4| 7| 6| 7| 7| 4| 4| 7| 6| 6| 7| 7| 5| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 8| 8| 2| 3| 8| 3| 5| 3| 8| 3| 2| 5| 7| 3| 2| 1| 3| 3| 7| 9| 7| 3| 7| 1| 1|
| 1| 3| 5| 1| 9| 0| 8| 2| 8| 3| 9| 9| 8| 0| 4| 8| 3| 1| 2| 8| 0| 2| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | 4 3 2 |
Cyst | X |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + +|
Acinus, Ectasia | 3 4 4 2 2 2 3 3 2 2 2|
Duct, Ectasia | 3 3 4 2 2 3 1 2 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3|
Cyst Epithelial Inclusion | X |
Hair Follicle, Inflammation, Chronic | |
Head, Inflammation, Acute | 4 |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Abscess | |
Cranium, Fibrous Osteodystrophy | X |
Femur, Fibrous Osteodystrophy | X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X |
Hemorrhage | 2 2 4 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Hemorrhage | 2 |
Infiltration Cellular, Lymphocyte | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Pigmentation, Cholesterol | 2 1 |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 2 2 2 1 2 1 |
Arteriole, Mineralization | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Interstitium, Inflammation, Chronic | 1 2 1 1|
Peribronchiolar, Inflammation, | |
Chronic | 4 3 |
Peribronchiolar, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 6| 2| 6| 7| 6| 7| 4| 7| 6| 7| 7| 4| 4| 7| 6| 6| 7| 7| 5| 6| 5| 7| 5| 7| 7|
DAY ON TEST | 8| 8| 2| 3| 8| 3| 5| 3| 8| 3| 2| 5| 7| 3| 2| 1| 3| 3| 7| 9| 7| 3| 7| 1| 1|
| 1| 3| 5| 1| 9| 0| 8| 2| 8| 3| 9| 9| 8| 0| 4| 8| 3| 1| 2| 8| 0| 2| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lumen, Foreign Body | 2 2 2 2 |
Lumen, Hemorrhage | 1 2 2 2 2 2 2 2 2 |
Mucosa, Hemorrhage | 1 |
Mucosa, Inflammation, Acute | 2 2 2 2 2 3 1 2 2 1 3 2 2 2 2 2 |
Nasolacrimal Duct, Degeneration | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | 1 |
Olfactory Epithelium, Degeneration | 2 2 2 2 2 3 3 2 3 2 2 2 2 2 3 3 2 1 3 2 3 3|
Olfactory Epithelium, Erosion | 2 |
Olfactory Epithelium, Metaplasia | 3 |
Respiratory Epithelium, Degeneration | 3 2 2 3 3 2 2 1 1 3 1 2 1 1 1 3 1|
Respiratory Epithelium, Erosion | 2 2 2 2 2 |
Respiratory Epithelium, Hemorrhage | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Nephropathy, Chronic | 2 2 4 4 4 3 4 3 3 2 4 2 3 2 3 2 3 3 3 3 4 3|
Pelvis, Inflammation, Acute | |
Renal Tubule, Cyst | |
Renal Tubule, Hyperplasia | 3 2 4 |
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 4 2 2 2 3 2 2 2 2 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 4| 0| 6|
DAY ON TEST | 2| 7| 3| 3| 3| 2| 2| 9| 3| 9| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 5| 2| 8|
| 9| 0| 3| 2| 3| 9| 9| 8| 3| 8| 1| 9| 1| 0| 1| 2| 8| 2| 3| 9| 0| 1| 8| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Hemorrhage | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Parasite Metazoan | X X |
Ulcer | 3 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 2 2 2 2 |
Congestion | |
Developmental Malformation | X |
Fatty Change | 1 |
Focal Cellular Change | X X X X X X X X X X X |
Granuloma | |
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 |
Necrosis | 3 |
Bile Duct, Dilatation | |
Bile Duct, Hyperplasia | 2 3 2 2 2 2 2 2 4 2 1 2 3 2 2 2 2 2 2 2 2|
Bile Duct, Inflammation, Chronic | |
Portal, Inflammation, Chronic | 2 2 2 2 2 2 1 3 2 1 2 2 2 3 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Acute | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Acinus, Atrophy | 2 2 2 3 3 1 4 2 1 1 2 2 3 2 1 2 |
Acinus, Hyperplasia | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic | 3 |
Acinus, Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia, Squamous | |
Inflammation, Acute | 2 1 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 4| 0| 6|
DAY ON TEST | 2| 7| 3| 3| 3| 2| 2| 9| 3| 9| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 5| 2| 8|
| 9| 0| 3| 2| 3| 9| 9| 8| 3| 8| 1| 9| 1| 0| 1| 2| 8| 2| 3| 9| 0| 1| 8| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 |
Ulcer | 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Congestion | |
Mucosa, Dilatation | 2 2 1 1 1 1 2 2 |
Mucosa, Erosion | 1 2 2 2|
Mucosa, Granuloma | 2 |
Mucosa, Hemorrhage | 3 |
Mucosa, Inflammation, Acute | 3|
Mucosa, Ulcer | 4 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 3 2 2 2 2 3 3 2 2 2 2 2 1 2 2 1 1|
Hemorrhage | |
Atrium, Thrombosis | X |
Pericardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 2 1 2 2 2 1 3 2 1 1 1 1 2 1|
Hyperplasia | 2 2 2 2 2 2 2 |
Hypertrophy | 2 2 2 2 1 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 1 1 2 2 2 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + M + + + + + M + +|
Hyperplasia | 3|
Hypertrophy | 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 3 2 2 2 2 3 3 1 |
Pars Intermedia, Angiectasis | 3|
Pars Intermedia, Cyst | X |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 1 2 1 1 1 |
Follicle, Ectasia | 1|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 4| 0| 6|
DAY ON TEST | 2| 7| 3| 3| 3| 2| 2| 9| 3| 9| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 5| 2| 8|
| 9| 0| 3| 2| 3| 9| 9| 8| 3| 8| 1| 9| 1| 0| 1| 2| 8| 2| 3| 9| 0| 1| 8| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | 2 4 2 3 2 2 2 3 2 2 2 2 2 2|
Inflammation, Chronic Active | 3 4 3 3 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Acute | 1 2 2 2 |
Inflammation, Chronic | 2 1 |
Inflammation, Chronic Active | 2 2 3 4 |
__________________________________________________________________________|
Seminal Vesicle | + |
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 2 2 |
Congestion | |
Mineralization | 3 |
Arteriole, Inflammation, Chronic | 4 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | |
Mediastinal, Congestion | 3 3 4 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mesenteric, Congestion | 2 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 |
Mesenteric, Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M +|
Congestion | 3 3 2 2 3 |
Cyst | |
Hyperplasia, Lymphoid | 2 2 2 2 3 3 2 3 2 2 2 2 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 4 |
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 1 2 2 2 2 2 2 2 2 3 2|
Infarct | |
Pigmentation | 2 2 2 2 2 1 2 2 2 2 1 2 3 2 2 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 4| 0| 6|
DAY ON TEST | 2| 7| 3| 3| 3| 2| 2| 9| 3| 9| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 5| 2| 8|
| 9| 0| 3| 2| 3| 9| 9| 8| 3| 8| 1| 9| 1| 0| 1| 2| 8| 2| 3| 9| 0| 1| 8| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | 2 2 |
Cyst | |
Hyperplasia, Lymphoid | 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Acinus, Ectasia | 2 2 3 2 2 2 2 4 2 1 1 4 2|
Duct, Ectasia | 2 2 2 2 2 2 4 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst Epithelial Inclusion | X |
Hair Follicle, Inflammation, Chronic | 2 |
Head, Inflammation, Acute | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Cranium, Abscess | |
Cranium, Fibrous Osteodystrophy | |
Femur, Fibrous Osteodystrophy | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hemorrhage | 2 2 4|
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hemorrhage | 2|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Pigmentation, Cholesterol | |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 2 2 2 2 2 2|
Arteriole, Mineralization | 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2|
Interstitium, Inflammation, Chronic | 1 2 |
Peribronchiolar, Inflammation, | |
Chronic | |
Peribronchiolar, Inflammation, | |
Chronic Active | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 4| 0| 6|
DAY ON TEST | 2| 7| 3| 3| 3| 2| 2| 9| 3| 9| 3| 5| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 5| 2| 8|
| 9| 0| 3| 2| 3| 9| 9| 8| 3| 8| 1| 9| 1| 0| 1| 2| 8| 2| 3| 9| 0| 1| 8| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
600 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lumen, Foreign Body | 2 |
Lumen, Hemorrhage | 2 2 2 2 1 2 2 2 2 2 1 2 1|
Mucosa, Hemorrhage | |
Mucosa, Inflammation, Acute | 2 4 2 2 2 2 2 2 2 2 2|
Nasolacrimal Duct, Degeneration | |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Olfactory Epithelium, Degeneration | 3 2 3 2 3 2 2 2 3 3 3 3 3 2 2 3 3 2 3 3|
Olfactory Epithelium, Erosion | 3 2 |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Degeneration | 1 1 1 2 1 1 1 1 1 2 1 2 2 1 |
Respiratory Epithelium, Erosion | 2 |
Respiratory Epithelium, Hemorrhage | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 2 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Nephropathy, Chronic | 3 3 4 4 3 3 3 4 3 2 4 3 4 3 3 2 2 4 4 2|
Pelvis, Inflammation, Acute | |
Renal Tubule, Cyst | X |
Renal Tubule, Hyperplasia | 4 |
Renal Tubule, Pigmentation | 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 4 |
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 4| 4| 7| 4| 7| 7| 7| | |
DAY ON TEST | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3| | |
| 3| 9| 4| 8| 9| 3| 8| 0| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 50 |
Erosion | | 1 1.0|
Hemorrhage | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 50 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 50 |
Erosion | | 1 3.0|
Parasite Metazoan | | 4 |
Ulcer | | 4 3.3|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 50 |
Angiectasis | 2 | 11 2.0|
Congestion | 3 | 2 3.0|
Developmental Malformation | | 4 |
Fatty Change | | 2 2.5|
Focal Cellular Change | X | 23 |
Granuloma | | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 2 1.0|
Hemorrhage | | 2 2.0|
Necrosis | | 2 3.0|
Bile Duct, Dilatation | 4 | 1 4.0|
Bile Duct, Hyperplasia | 1 3 3 2 3 2 | 49 2.2|
Bile Duct, Inflammation, Chronic | 4 | 1 4.0|
Portal, Inflammation, Chronic | 3 2 1 2 2 | 45 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 50 |
Inflammation, Acute | | 1 3.0|
Acinus, Atrophy | 2 2 1 | 34 2.2|
Acinus, Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation, Chronic | | 1 3.0|
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 4| 4| 7| 4| 7| 7| 7| | |
DAY ON TEST | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3| | |
| 3| 9| 4| 8| 9| 3| 8| 0| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 50 |
Erosion | 3 | 1 3.0|
Hyperplasia, Squamous | 2 | 1 2.0|
Inflammation, Acute | | 3 2.3|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 2 3.0|
Ulcer | 4 4 | 7 3.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 50 |
Mucosa, Congestion | | 1 2.0|
Mucosa, Dilatation | 2 2 2 | 21 1.7|
Mucosa, Erosion | 3 | 11 2.1|
Mucosa, Granuloma | | 1 2.0|
Mucosa, Hemorrhage | | 1 3.0|
Mucosa, Inflammation, Acute | | 1 3.0|
Mucosa, Ulcer | 4 | 5 3.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + | 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + | 50 |
Cardiomyopathy, Chronic | 3 2 3 2 2 | 47 2.2|
Hemorrhage | 2 | 1 2.0|
Atrium, Thrombosis | X X | 6 |
Pericardium, Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 50 |
Degeneration, Fatty | 2 2 1 2 2 2 | 41 1.7|
Hyperplasia | 2 | 10 2.0|
Hypertrophy | | 5 1.8|
Pigmentation | 2 2 2 2 1 2 | 46 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 50 |
Hyperplasia | 2 2 3 2 | 15 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 50 |
Hyperplasia | | 4 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + | 45 |
Hyperplasia | | 1 3.0|
Hypertrophy | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 4| 4| 7| 4| 7| 7| 7| | |
DAY ON TEST | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3| | |
| 3| 9| 4| 8| 9| 3| 8| 0| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 50 |
Pars Distalis, Angiectasis | | 3 2.3|
Pars Distalis, Cyst | | 6 |
Pars Distalis, Hyperplasia | 3 2 3 | 22 2.4|
Pars Intermedia, Angiectasis | | 2 3.0|
Pars Intermedia, Cyst | | 2 |
Pars Intermedia, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 50 |
C-Cell, Hyperplasia | 1 1 | 20 1.5|
Follicle, Ectasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 50 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 2 2 | 28 2.2|
Inflammation, Chronic Active | 3 2 2 | 17 2.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 50 |
Hyperplasia | | 3 1.7|
Inflammation, Acute | 3 | 7 2.0|
Inflammation, Chronic | | 3 1.7|
Inflammation, Chronic Active | 3 | 6 2.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 5 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + | 50 |
Atrophy | 1 | 12 2.6|
Congestion | | 1 2.0|
Mineralization | | 2 2.0|
Arteriole, Inflammation, Chronic | 2 | 2 3.0|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 | 46 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 50 |
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 4| 4| 7| 4| 7| 7| 7| | |
DAY ON TEST | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3| | |
| 3| 9| 4| 8| 9| 3| 8| 0| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Congestion | | 1 3.0|
Hyperplasia, Lymphoid | | 2 2.0|
Mediastinal, Congestion | | 5 3.6|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mesenteric, Congestion | | 1 2.0|
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 | 20 2.0|
Mesenteric, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 45 |
Congestion | 4 | 10 2.5|
Cyst | | 1 |
Hyperplasia, Lymphoid | 3 2 3 2 | 31 2.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 50 |
Fibrosis | | 3 3.0|
Hematopoietic Cell Proliferation | 2 2 2 1 2 | 42 2.0|
Infarct | | 1 4.0|
Pigmentation | 2 1 2 1 1 | 37 1.8|
__________________________________________________________________________|____________|
Thymus | + + M + + M | 46 |
Congestion | | 5 2.6|
Cyst | | 1 |
Hyperplasia, Lymphoid | 3 | 4 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + | 48 |
Acinus, Ectasia | 3 | 25 2.4|
Duct, Ectasia | 2 | 19 2.4|
__________________________________________________________________________|____________|
Skin | + + + + + + | 50 |
Abscess | | 1 3.0|
Cyst Epithelial Inclusion | | 2 |
Hair Follicle, Inflammation, Chronic | | 1 2.0|
Head, Inflammation, Acute | | 1 4.0|
Subcutaneous Tissue, Edema | 4 | 1 4.0|
Subcutaneous Tissue, Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 50 |
Cranium, Abscess | 4 | 1 4.0|
Cranium, Fibrous Osteodystrophy | | 1 |
Femur, Fibrous Osteodystrophy | X | 4 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 4| 4| 7| 4| 7| 7| 7| | |
DAY ON TEST | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3| | |
| 3| 9| 4| 8| 9| 3| 8| 0| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 50 |
Compression | | 7 |
Hemorrhage | 4 | 8 2.6|
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + | 50 |
Congestion | | 3 3.0|
Hemorrhage | 2 1 | 4 1.8|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 | 47 2.0|
Pigmentation, Cholesterol | | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 2 2.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 | 18 1.8|
Arteriole, Mineralization | 2 2 2 2 2 | 40 2.0|
Interstitium, Inflammation, Chronic | | 6 1.3|
Peribronchiolar, Inflammation, | | |
Chronic | 3 | 3 3.3|
Peribronchiolar, Inflammation, | | |
Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 50 |
Lumen, Foreign Body | | 5 2.0|
Lumen, Hemorrhage | 2 1 3 | 25 1.8|
Mucosa, Hemorrhage | | 1 1.0|
Mucosa, Inflammation, Acute | 2 3 2 | 30 2.1|
Nasolacrimal Duct, Degeneration | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 1.0|
Olfactory Epithelium, Degeneration | 3 2 3 3 2 2 | 48 2.5|
Olfactory Epithelium, Erosion | | 3 2.3|
Olfactory Epithelium, Metaplasia | | 1 3.0|
Respiratory Epithelium, Degeneration | 1 2 2 1 1 1 | 37 1.6|
Respiratory Epithelium, Erosion | | 6 2.0|
Respiratory Epithelium, Hemorrhage | | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 50 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 7| 4| 6| 4| 4| 7| 4| 7| 7| 7| | |
DAY ON TEST | 1| 5| 1| 5| 5| 3| 5| 3| 2| 3| | |
| 3| 9| 4| 8| 9| 3| 8| 0| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
600 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 50 |
Congestion | 3 | 1 3.0|
Nephropathy, Chronic | 3 3 4 4 2 4 | 48 3.1|
Pelvis, Inflammation, Acute | 3 | 1 3.0|
Renal Tubule, Cyst | X | 2 |
Renal Tubule, Hyperplasia | | 4 3.3|
Renal Tubule, Pigmentation | 2 2 2 2 1 2 | 48 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 50 |
Calculus Micro Observation Only | X | 1 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | | 1 4.0|
Transitional Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 5| 6| 4| 6|
DAY ON TEST | 3| 3| 9| 3| 5| 2| 4| 4| 9| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 2| 5| 9| 7| 5| 5|
| 3| 1| 1| 2| 8| 2| 0| 3| 6| 2| 2| 2| 0| 9| 6| 1| 6| 1| 1| 6| 2| 7| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + +|
Granuloma | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Parasite Metazoan | X X X X |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Congestion | |
Developmental Malformation | X |
Fatty Change | 1 2 1 3 |
Focal Cellular Change | X X X X X X X X X X |
Granuloma | 2 |
Necrosis | 2|
Bile Duct, Hyperplasia | 3 2 2 2 1 2 2 3 2 1 2 2 2 1 2 3 3 2 2 2 1 2 3|
Portal, Inflammation, Chronic | 2 2 2 2 2 2 2 2 1 2 1 2 1 2 3 2 1 2 2 2 2|
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Mesentery | + |
Arteriole, Inflammation, Chronic | 2 |
Arteriole, Inflammation, Chronic | |
Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 2 3 2 2 1 2 3 1 2 |
Acinus, Hyperplasia | |
Arteriole, Inflammation, Chronic | |
Active | |
Arteriole, Mineralization | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 |
Arteriole, Mineralization | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 5| 6| 4| 6|
DAY ON TEST | 3| 3| 9| 3| 5| 2| 4| 4| 9| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 2| 5| 9| 7| 5| 5|
| 3| 1| 1| 2| 8| 2| 0| 3| 6| 2| 2| 2| 0| 9| 6| 1| 6| 1| 1| 6| 2| 7| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | |
Hyperplasia, Squamous | |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 4 2 |
Mineralization | 3 |
Ulcer | 3 4 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
Mineralization | 3 |
Mucosa, Dilatation | 2 2 2 2 2 2|
Mucosa, Erosion | 2 2 2 2 1 1|
Mucosa, Ulcer | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | 3 |
Thoracic, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 1 4 2 2 3 3 3 3 2 3 2 2 1 1 2 2 3 2 2 3 3|
Mineralization | 3 |
Artery, Mineralization | |
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 1 2 1 2 2 1 1 1 3 2 2 2 2 3 3 2 2|
Hyperplasia | 1 2 1 3 2 |
Hypertrophy | 2|
Pigmentation | 1 1 2 2 2 2 2 1 1 2 1 2 1 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hemorrhage | 2 |
Pars Distalis, Hyperplasia | 3 2 2 3 2 2 |
Pars Intermedia, Angiectasis | 3 |
Pars Intermedia, Cyst | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 5| 6| 4| 6|
DAY ON TEST | 3| 3| 9| 3| 5| 2| 4| 4| 9| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 2| 5| 9| 7| 5| 5|
| 3| 1| 1| 2| 8| 2| 0| 3| 6| 2| 2| 2| 0| 9| 6| 1| 6| 1| 1| 6| 2| 7| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Ultimobranchial Cyst | X X |
C-Cell, Hyperplasia | 1 1 1 1 2 |
Follicle, Ectasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 2 |
Inflammation, Chronic Active | 3 2 2 2 3 3 2 3 2 3 3 3|
Mineralization | 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 |
Inflammation, Acute | 2 4|
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 4|
Arteriole, Inflammation, Chronic | |
Interstitial Cell, Hyperplasia | 1 2 2 2 2 2 2 2 2 2 1 2 1 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mesenteric, Congestion | 2 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 |
Popliteal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M M M + + + + + M + M + + + + M + +|
Congestion | 2 |
Cyst | |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 3 |
Hematopoietic Cell Proliferation | 2 2 1 2 3 2 2 2 2 2 1 1 2 2 2 3 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 5| 6| 4| 6|
DAY ON TEST | 3| 3| 9| 3| 5| 2| 4| 4| 9| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 2| 5| 9| 7| 5| 5|
| 3| 1| 1| 2| 8| 2| 0| 3| 6| 2| 2| 2| 0| 9| 6| 1| 6| 1| 1| 6| 2| 7| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 |
Pigmentation | 2 1 3 2 2 2 2 2 1 2 1 3 1 2 2 1 2 2 1|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + +|
Acinus, Ectasia | 2 2 3 2 1 3 3 2 4 2 3 3|
Duct, Ectasia | 3 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Foot, Ulcer | |
Head, Abscess | 2 |
Head, Inflammation, Acute | |
Tail, Subcutaneous Tissue, | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | 4 |
Cranium, Inflammation, Chronic | |
Femur, Fibrous Osteodystrophy | 3 |
Humerus, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hemorrhage | |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Hemorrhage | 1 1 1 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Inflammation, Chronic | 1 |
Metaplasia, Osseous | |
Pigmentation, Cholesterol | |
Alveolar Epithelium, Hyperplasia | 2 2 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 2 2 2 2 1 2 2 2 2 |
Alveolus, Mineralization | 2 |
Arteriole, Mineralization | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 5| 5| 5| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 6| 5| 6| 4| 6|
DAY ON TEST | 3| 3| 9| 3| 5| 2| 4| 4| 9| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 2| 5| 9| 7| 5| 5|
| 3| 1| 1| 2| 8| 2| 0| 3| 6| 2| 2| 2| 0| 9| 6| 1| 6| 1| 1| 6| 2| 7| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Bronchiole, Inflammation, Acute | 2 |
Interstitium, Inflammation, Chronic | 1 1 1 |
Interstitium, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + A + + + + + + + + + + + + + + + + +|
Lumen, Degeneration | 2 |
Lumen, Foreign Body | 2 2 |
Lumen, Hemorrhage | 2 3 2 2 1 2 1 1 2 3 2 2 3 2 3|
Mucosa, Inflammation, Acute | 2 3 3 3 2 1 2 2 2 2 2 1 2 1 2 2 2 2 2|
Nasolacrimal Duct, Inflammation, | |
Acute | 3 2|
Olfactory Epithelium, Degeneration | 4 3 3 2 1 2 2 3 3 3 2 3 2 2 3 3 3 2 3|
Olfactory Epithelium, Erosion | 2 2 2 2 1 |
Olfactory Epithelium, Metaplasia | |
Olfactory Epithelium, Metaplasia, | |
Squamous | 2 |
Respiratory Epithelium, Degeneration | 3 2 1 1 2 1 3 3 2 2 2 2 3 3 1 |
Respiratory Epithelium, Erosion | 2 |
Respiratory Epithelium, Ulcer | |
Vomeronasal Organ, Inflammation, | |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 2 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | |
Sclera, Mineralization | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Mineralization | 3 |
Nephropathy, Chronic | 2 3 4 3 4 3 3 4 4 4 4 4 4 2 3 2 4 4 2 4 4 4|
Pelvis, Inflammation, Acute | 4 |
Renal Tubule, Cyst | X X |
Renal Tubule, Pigmentation | 1 1 2 1 2 2 2 1 1 2 2 1 2 2 2 3 2 2 1 2 2 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 4| 4| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 5| 7| 4| 4| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 2| 5| 3| 9| 3| 2| 0| 3| 2| 5| 5| 3| 6| 3| 0| 5| 1| 5| 7| 3| 2| 3|
| 8| 9| 8| 6| 8| 2| 7| 0| 9| 4| 3| 9| 9| 9| 3| 0| 2| 8| 6| 5| 9| 8| 3| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
Granuloma | 3 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Parasite Metazoan | X X |
Ulcer | 3 4 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 2 |
Developmental Malformation | X|
Fatty Change | 2 2 2 |
Focal Cellular Change | X X X X X X X X X|
Granuloma | |
Necrosis | |
Bile Duct, Hyperplasia | 2 2 1 3 2 1 3 2 2 1 2 2 4 3 2 2 2 2 2|
Portal, Inflammation, Chronic | 2 2 2 2 1 2 2 2 1 2 2 3 2 2 2 2 2 2|
Serosa, Fibrosis | |
__________________________________________________________________________|
Mesentery | + + |
Arteriole, Inflammation, Chronic | 2 |
Arteriole, Inflammation, Chronic | |
Active | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 2 2 2 2 2 3 2 2 3 3 2 2 1 2 1|
Acinus, Hyperplasia | 2 |
Arteriole, Inflammation, Chronic | |
Active | 3 |
Arteriole, Mineralization | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Arteriole, Mineralization | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 4| 4| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 5| 7| 4| 4| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 2| 5| 3| 9| 3| 2| 0| 3| 2| 5| 5| 3| 6| 3| 0| 5| 1| 5| 7| 3| 2| 3|
| 8| 9| 8| 6| 8| 2| 7| 0| 9| 4| 3| 9| 9| 9| 3| 0| 2| 8| 6| 5| 9| 8| 3| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | |
Hyperplasia, Squamous | 3 |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Mineralization | |
Ulcer | 3 4 3 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | |
Mucosa, Dilatation | 2 2 2 2 2 2 2 |
Mucosa, Erosion | 3 2 |
Mucosa, Ulcer | 3 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + +|
Aorta, Mineralization | |
Thoracic, Inflammation, Chronic | |
Active | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 3 2 2 2 3 2 2 2 2 3 3 2 2 2 2 3 3 3|
Mineralization | |
Artery, Mineralization | |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 1 2 2 1 1 2 1 1 2 1 2 1 3 2 1 1 |
Hyperplasia | 2 2 2 1 1 |
Hypertrophy | 2 |
Pigmentation | 2 2 2 1 2 2 1 2 2 2 2 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + M + + + M + + M + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 1 2 2 2 |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | X |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 4| 4| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 5| 7| 4| 4| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 2| 5| 3| 9| 3| 2| 0| 3| 2| 5| 5| 3| 6| 3| 0| 5| 1| 5| 7| 3| 2| 3|
| 8| 9| 8| 6| 8| 2| 7| 0| 9| 4| 3| 9| 9| 9| 3| 0| 2| 8| 6| 5| 9| 8| 3| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 1 1 1 2 2 1 |
Follicle, Ectasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic | 3 1 2 1 3 2 |
Inflammation, Chronic Active | 2 2 2 2 3 2 3 3 2 3 3|
Mineralization | |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 2 4 3 3 4 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 4 |
Arteriole, Inflammation, Chronic | 2 |
Interstitial Cell, Hyperplasia | 2 2 2 2 1 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Mesenteric, Congestion | 2 3 2 |
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 1 1 2 2 2|
Popliteal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M M M + + + + + + M + + M + + + + +|
Congestion | 2 2|
Cyst | |
Hyperplasia, Lymphoid | 3 2 2 2 2 2 2 1 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 1 1 1 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 4| 4| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 5| 7| 4| 4| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 2| 5| 3| 9| 3| 2| 0| 3| 2| 5| 5| 3| 6| 3| 0| 5| 1| 5| 7| 3| 2| 3|
| 8| 9| 8| 6| 8| 2| 7| 0| 9| 4| 3| 9| 9| 9| 3| 0| 2| 8| 6| 5| 9| 8| 3| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 2 |
Pigmentation | 2 2 2 2 2 1 1 2 2 2 2 3 2 2 1 2|
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + M + + + +|
Congestion | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +|
Acinus, Ectasia | 3 4 4 2 2 3 3 2 1 1|
Duct, Ectasia | 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Abscess | |
Foot, Ulcer | 4 |
Head, Abscess | |
Head, Inflammation, Acute | |
Tail, Subcutaneous Tissue, | |
Inflammation, Acute | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | 1 |
Cranium, Inflammation, Chronic | |
Femur, Fibrous Osteodystrophy | 1 |
Humerus, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hemorrhage | 2 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 |
Hemorrhage | 1 2 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Inflammation, Chronic | |
Metaplasia, Osseous | 1 |
Pigmentation, Cholesterol | 2 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 2 2 1 2 2 2 1 1|
Alveolus, Mineralization | 2 |
Arteriole, Mineralization | 2 2 2 2 2 2 1 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
_____________________________________________________________________________________________________________________
| 4| 4| 4| 7| 5| 6| 5| 7| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 5| 7| 4| 4| 7| 7| 7|
DAY ON TEST | 5| 5| 5| 2| 5| 3| 9| 3| 2| 0| 3| 2| 5| 5| 3| 6| 3| 0| 5| 1| 5| 7| 3| 2| 3|
| 8| 9| 8| 6| 8| 2| 7| 0| 9| 4| 3| 9| 9| 9| 3| 0| 2| 8| 6| 5| 9| 8| 3| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
1200 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Bronchiole, Inflammation, Acute | 3 |
Interstitium, Inflammation, Chronic | 1 1 1 1 1 |
Interstitium, Inflammation, Chronic | |
Active | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Lumen, Degeneration | |
Lumen, Foreign Body | |
Lumen, Hemorrhage | 2 2 2 2 2 2 2 2 2 3 3 2 2|
Mucosa, Inflammation, Acute | 1 2 2 2 1 2 2 2 3 2 2 2 1 2|
Nasolacrimal Duct, Inflammation, | |
Acute | |
Olfactory Epithelium, Degeneration | 3 1 2 3 3 2 3 3 1 3 2 2 2 3 3 3|
Olfactory Epithelium, Erosion | 2 2 |
Olfactory Epithelium, Metaplasia | |
Olfactory Epithelium, Metaplasia, | |
Squamous | 2 |
Respiratory Epithelium, Degeneration | 2 2 2 2 2 1 2 1 1|
Respiratory Epithelium, Erosion | 3 2 |
Respiratory Epithelium, Ulcer | 2 |
Vomeronasal Organ, Inflammation, | |
Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Cataract | 2|
Retina, Degeneration | 4|
Sclera, Mineralization | 2|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Infarct | 3|
Mineralization | |
Nephropathy, Chronic | 4 3 4 3 4 4 4 4 2 2 3 2 4 2 4 2 1 4 3|
Pelvis, Inflammation, Acute | |
Renal Tubule, Cyst | X X |
Renal Tubule, Pigmentation | 2 2 2 1 1 2 3 2 1 1 1 3 2 2 2 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 2| 6| 7| 6| 4| | |
DAY ON TEST | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5| | |
| 5| 0| 1| 9| 8| 5| 1| 9| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 49 |
Granuloma | | 1 3.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 49 |
Inflammation, Acute | | 1 3.0|
Parasite Metazoan | X | 7 |
Ulcer | | 3 3.3|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 49 |
Erosion | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 49 |
Erosion | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Angiectasis | 2 | 3 2.0|
Congestion | | 1 2.0|
Developmental Malformation | | 2 |
Fatty Change | 3 | 8 2.0|
Focal Cellular Change | X X X X | 23 |
Granuloma | | 1 2.0|
Necrosis | | 1 2.0|
Bile Duct, Hyperplasia | 2 2 2 2 3 2 2 | 49 2.1|
Portal, Inflammation, Chronic | 2 2 2 2 1 3 1 | 46 1.9|
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Arteriole, Inflammation, Chronic | | 2 2.0|
Arteriole, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Acinus, Atrophy | 2 3 3 | 30 2.1|
Acinus, Hyperplasia | | 1 2.0|
Arteriole, Inflammation, Chronic | | |
Active | | 1 3.0|
Arteriole, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 2| 6| 7| 6| 4| | |
DAY ON TEST | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5| | |
| 5| 0| 1| 9| 8| 5| 1| 9| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinus, Atrophy | | 1 1.0|
Arteriole, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 49 |
Erosion | 3 | 1 3.0|
Hyperplasia, Squamous | 3 | 2 3.0|
Inflammation, Acute | 3 | 2 2.5|
Inflammation, Chronic Active | | 2 3.0|
Mineralization | | 1 3.0|
Ulcer | 4 | 9 3.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 49 |
Inflammation, Chronic Active | | 1 4.0|
Mineralization | 2 | 2 2.5|
Mucosa, Dilatation | 1 2 2 2 2 | 18 1.9|
Mucosa, Erosion | 3 | 9 2.0|
Mucosa, Ulcer | | 3 3.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + | 50 |
Aorta, Mineralization | | 1 3.0|
Thoracic, Inflammation, Chronic | | |
Active | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Cardiomyopathy, Chronic | 1 2 2 2 3 3 2 | 47 2.3|
Mineralization | | 1 3.0|
Artery, Mineralization | 2 | 1 2.0|
Atrium, Thrombosis | | 3 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Degeneration, Fatty | 3 1 1 3 2 1 1 2 | 43 1.7|
Hyperplasia | 2 | 11 1.7|
Hypertrophy | 2 | 3 2.0|
Pigmentation | 1 2 2 2 | 39 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 50 |
Hyperplasia | 2 | 4 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 2| 6| 7| 6| 4| | |
DAY ON TEST | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5| | |
| 5| 0| 1| 9| 8| 5| 1| 9| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + | 44 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 50 |
Pars Distalis, Angiectasis | 3 | 1 3.0|
Pars Distalis, Cyst | | 5 |
Pars Distalis, Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia | 2 | 11 2.1|
Pars Intermedia, Angiectasis | | 1 3.0|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Ultimobranchial Cyst | | 2 |
C-Cell, Hyperplasia | 1 2 | 14 1.4|
Follicle, Ectasia | 2 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 50 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic | 2 3 3 1 2 2 | 22 2.0|
Inflammation, Chronic Active | 2 3 | 25 2.5|
Mineralization | | 1 2.0|
Duct, Ectasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 50 |
Hyperplasia | | 3 1.7|
Inflammation, Acute | 4 2 | 5 2.8|
Inflammation, Chronic | 2 | 2 2.0|
Inflammation, Chronic Active | 3 2 | 10 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 50 |
Atrophy | 3 3 | 9 3.1|
Arteriole, Inflammation, Chronic | | 1 2.0|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 | 37 1.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 2| 6| 7| 6| 4| | |
DAY ON TEST | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5| | |
| 5| 0| 1| 9| 8| 5| 1| 9| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 50 |
Myelofibrosis | 2 3 | 5 2.4|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
Mediastinal, Hemorrhage | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mesenteric, Congestion | | 4 2.3|
Mesenteric, Hyperplasia, Lymphoid | 2 2 2 2 2 | 22 1.9|
Popliteal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M M + + + | 37 |
Congestion | | 3 2.0|
Cyst | X | 1 |
Hyperplasia, Lymphoid | 2 2 2 3 2 | 30 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Fibrosis | | 4 2.8|
Hematopoietic Cell Proliferation | 2 2 2 2 1 1 | 40 1.8|
Hyperplasia, Lymphoid | | 3 2.0|
Pigmentation | 2 2 1 2 2 1 2 | 42 1.8|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + | 46 |
Congestion | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 49 |
Acinus, Ectasia | 2 3 4 3 2 3 | 28 2.6|
Duct, Ectasia | 3 3 | 8 2.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 50 |
Abscess | 4 | 1 4.0|
Foot, Ulcer | | 1 4.0|
Head, Abscess | | 1 2.0|
Head, Inflammation, Acute | 2 | 1 2.0|
Tail, Subcutaneous Tissue, | | |
Inflammation, Acute | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
Cranium, Fibrous Osteodystrophy | | 2 2.5|
Cranium, Inflammation, Chronic | 4 | 1 4.0|
Femur, Fibrous Osteodystrophy | | 2 2.0|
Humerus, Fracture | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 2| 6| 7| 6| 4| | |
DAY ON TEST | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5| | |
| 5| 0| 1| 9| 8| 5| 1| 9| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Compression | X X | 6 |
Hemorrhage | | 2 2.0|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Congestion | | 4 2.0|
Hemorrhage | | 5 1.2|
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 2 2 2 | 49 2.0|
Inflammation, Chronic | | 1 1.0|
Metaplasia, Osseous | | 1 1.0|
Pigmentation, Cholesterol | | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 3 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 2 2 | 25 1.7|
Alveolus, Mineralization | | 2 2.0|
Arteriole, Mineralization | 2 2 2 2 2 2 2 1 | 38 1.9|
Bronchiole, Inflammation, Acute | | 2 2.5|
Interstitium, Inflammation, Chronic | 1 1 | 10 1.0|
Interstitium, Inflammation, Chronic | | |
Active | 2 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 49 |
Lumen, Degeneration | | 1 2.0|
Lumen, Foreign Body | | 2 2.0|
Lumen, Hemorrhage | 3 1 3 2 3 2 2 | 35 2.1|
Mucosa, Inflammation, Acute | 1 2 2 1 1 1 2 | 40 1.9|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 2 2.5|
Olfactory Epithelium, Degeneration | 3 3 3 3 3 3 3 | 42 2.6|
Olfactory Epithelium, Erosion | 2 | 8 1.9|
Olfactory Epithelium, Metaplasia | 2 | 1 2.0|
Olfactory Epithelium, Metaplasia, | | |
Squamous | | 2 2.0|
Respiratory Epithelium, Degeneration | 1 1 2 3 1 2 2 | 31 1.9|
Respiratory Epithelium, Erosion | | 3 2.3|
Respiratory Epithelium, Ulcer | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05701-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOLUENE Date: 05/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:31:19
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 2| 6| 7| 6| 4| | |
DAY ON TEST | 9| 3| 3| 1| 5| 0| 4| 2| 8| 5| | |
| 5| 0| 1| 9| 8| 5| 1| 9| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A |
1200 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Vomeronasal Organ, Inflammation, | | |
Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
Inflammation, Acute | | 3 1.7|
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 2 2.5|
Retina, Degeneration | | 1 4.0|
Sclera, Mineralization | | 2 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Infarct | 3 | 2 3.0|
Mineralization | | 1 3.0|
Nephropathy, Chronic | 2 3 4 4 3 4 4 | 48 3.3|
Pelvis, Inflammation, Acute | | 1 4.0|
Renal Tubule, Cyst | X | 5 |
Renal Tubule, Pigmentation | 2 1 1 2 2 2 2 | 47 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 50 |
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
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