TR 373 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
SUCCINIC ANHYDRIDE
NTP Experiment-Test: 05041-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/05/94
Route: GAVAGE Time: 13:16:48
Facility: Microbiological Associates
Chemical CAS #: 108-30-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 50MG/KG 100MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Early Deaths
Dead 10 11 10
Moribund 18 15 14
Gavage Death 1 6 9
Accident 1
Survivors
Terminal Sacrifice 30 27 26
Dead 1
Moribund 1
Animals Examined Microscopically 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (54) (35) (53)
Adenocarcinoma, Extension 1 (2%)
Intestine Large, Colon (55) (44) (55)
Adenocarcinoma, Extension 1 (2%)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Intestine Small, Duodenum (55) (44) (52)
Adenocarcinoma, Extension 1 (2%)
Intestine Small, Ileum (53) (35) (51)
Liver (60) (52) (60)
Adenocarcinoma, Extension 1 (2%)
Neoplastic Nodule 2 (3%) 1 (2%) 2 (3%)
Neoplastic Nodule, Multiple 1 (2%)
Mesentery (6) (6) (3)
Adenocarcinoma, Extension 1 (17%)
Sarcoma, Metastatic, Skeletal Muscle 1 (17%)
Pancreas (59) (44) (59)
Adenocarcinoma, Extension 1 (2%)
Salivary Glands (60) (45) (59)
Stomach, Forestomach (58) (44) (57)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (58) (45) (54)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (45) (60)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 50MG/KG 100MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (45) (59)
Adenocarcinoma, Extension 1 (2%)
Adenoma, Multiple 1 (2%)
Carcinoma 1 (2%)
Adrenal Gland, Medulla (59) (43) (54)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 2 (3%) 1 (2%) 3 (6%)
Pheochromocytoma Benign, Multiple 1 (2%)
Pituitary Gland (60) (55) (60)
Pars Distalis, Adenoma 27 (45%) 25 (45%) 18 (30%)
Pars Distalis, Adenoma, Multiple 3 (5%) 1 (2%) 2 (3%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%)
Thyroid Gland (59) (45) (60)
C-Cell, Adenoma 5 (8%) 2 (4%) 5 (8%)
C-Cell, Carcinoma 4 (7%) 2 (4%) 3 (5%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (39) (27) (53)
Adenoma 2 (5%) 2 (7%) 3 (6%)
Squamous Cell Papilloma, Multiple 1 (3%)
Ovary (59) (44) (60)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Luteoma 1 (2%)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Uterus (59) (48) (60)
Adenocarcinoma 1 (2%)
Hemangiosarcoma 1 (2%)
Leiomyosarcoma 1 (2%)
Sarcoma 1 (2%)
Sarcoma Stromal 1 (2%)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Endometrium, Polyp Stromal 11 (19%) 8 (17%) 6 (10%)
Endometrium, Polyp Stromal, Multiple 3 (5%)
Endometrium, Sarcoma Stromal 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 50MG/KG 100MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (45) (60)
Lymph Node (59) (45) (60)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Lymph Node, Mandibular (54) (43) (55)
Lymph Node, Mesenteric (59) (43) (59)
Spleen (59) (46) (60)
Thymus (48) (41) (52)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (55) (59)
Adenocarcinoma 2 (4%) 2 (3%)
Adenoma 1 (2%) 2 (4%)
Fibroadenoma 17 (29%) 17 (31%) 12 (20%)
Fibroadenoma, Multiple 8 (14%) 6 (11%)
Skin (60) (44) (60)
Sarcoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Head, Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (45) (60)
Astrocytoma Benign 1 (2%)
Carcinoma 1 (2%)
Ependymoma Benign 1 (2%)
Oligodendroglioma Benign 1 (2%)
Spinal Cord (1) (1)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 50MG/KG 100MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (49) (60)
Adenocarcinoma, Metastatic, Uterus 1 (2%)
Alveolar/Bronchiolar Adenoma 3 (5%) 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (59) (60)
Nephroblastoma 2 (3%)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Urinary Bladder (56) (41) (60)
Leiomyosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60)
Leukemia Mononuclear 11 (18%) 6 (10%) 8 (13%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 50MG/KG 100MG/KG
FEMALE LOW FEM HIGHFEM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 55 47 39
Total Primary Neoplasms 117 86 77
Total Animals with Benign Neoplasms 52 42 34
Total Benign Neoplasms 87 68 59
Total Animals with Malignant Neoplasms 21 15 18
Total Malignant Neoplasms 30 18 18
Total Animals with Metastatic Neoplasms 2 1 1
Total Metastatic Neoplasm 5 1 5
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 50MG/KG 100MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Early Deaths
Moribund 15 16 10
Dead 8 9 14
Gavage Death 1 2 4
Survivors
Terminal Sacrifice 36 33 32
Animals Examined Microscopically 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (28) (60)
Leiomyosarcoma 1 (2%)
Intestine Large, Cecum (52) (24) (53)
Lipoma 1 (2%)
Intestine Small, Duodenum (52) (24) (53)
Leiomyosarcoma 1 (4%)
Intestine Small, Ileum (53) (24) (51)
Leiomyosarcoma 1 (2%)
Intestine Small, Jejunum (52) (23) (51)
Leiomyoma 1 (2%)
Liver (60) (47) (60)
Neoplastic Nodule 1 (2%)
Schwannoma Malignant, Metastatic, Peripheral
Nerve 1 (2%)
Mesentery (13) (14) (12)
Fibrosarcoma 1 (7%)
Sarcoma 1 (7%)
Schwannoma Malignant, Metastatic, Peripheral
Nerve 1 (7%)
Pancreas (59) (26) (59)
Schwannoma Malignant, Metastatic, Peripheral
Nerve 1 (4%)
Salivary Glands (58) (27) (58)
Adenocarcinoma 1 (4%)
Sarcoma 1 (2%) 1 (4%)
Stomach, Forestomach (59) (29) (58)
Stomach, Glandular (58) (31) (59)
Tooth (1) (1)
Neoplasm NOS 1 (100%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 50MG/KG 100MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (29) (59)
Adenocarcinoma, Metastatic, Salivary Glands 1 (3%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Endocardium, Schwannoma Malignant 1 (3%)
Epicardium, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (3%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (60) (59)
Carcinoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Adrenal Gland, Medulla (58) (58) (58)
Neuroblastoma Malignant 1 (2%)
Pheochromocytoma Malignant 4 (7%) 5 (9%) 2 (3%)
Pheochromocytoma Benign 14 (24%) 8 (14%) 9 (16%)
Pheochromocytoma Benign, Multiple 3 (5%) 1 (2%) 3 (5%)
Bilateral, Pheochromocytoma Malignant 1 (2%)
Islets, Pancreatic (59) (27) (60)
Adenoma 2 (7%) 1 (2%)
Adenoma, Multiple 1 (2%)
Carcinoma 1 (2%)
Parathyroid Gland (51) (26) (51)
Adenoma 1 (2%) 1 (2%)
Pituitary Gland (57) (59) (60)
Pars Distalis, Adenoma 19 (33%) 15 (25%) 13 (22%)
Pars Distalis, Adenoma, Multiple 1 (2%) 1 (2%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%)
Thyroid Gland (60) (60) (58)
C-Cell, Adenoma 7 (12%) 7 (12%) 5 (9%)
C-Cell, Carcinoma 6 (10%) 2 (3%) 2 (3%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Adenoma, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2)
Schwannoma Malignant, Metastatic, Spinal Cord 1 (50%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 50MG/KG 100MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (29) (59)
Preputial Gland (48) (23) (51)
Adenoma 4 (17%) 1 (2%)
Seminal Vesicle (59) (30) (57)
Schwannoma Malignant, Metastatic, Peripheral
Nerve 1 (3%)
Testes (60) (58) (60)
Adenoma 1 (2%)
Interstitial Cell, Adenoma 8 (13%) 4 (7%) 6 (10%)
Interstitial Cell, Adenoma, Multiple 48 (80%) 43 (74%) 42 (70%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (60) (29) (60)
Lymph Node, Mandibular (50) (28) (51)
Lymph Node, Mesenteric (57) (28) (59)
Spleen (59) (39) (60)
Hemangiosarcoma 1 (2%)
Schwannoma Malignant, Metastatic, Peripheral
Nerve 1 (3%)
Thymus (45) (28) (48)
Schwannoma Malignant 1 (4%)
Schwannoma Malignant, Metastatic, Peripheral
Nerve 1 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (25) (42)
Adenoma 1 (2%)
Fibroadenoma 1 (2%) 2 (8%) 1 (2%)
Skin (60) (29) (59)
Basal Cell Carcinoma 1 (2%) 1 (2%)
Keratoacanthoma 2 (3%) 6 (10%)
Squamous Cell Papilloma 2 (3%) 1 (3%)
Trichoepithelioma 2 (3%)
Subcutaneous Tissue, Fibroma 3 (5%) 3 (10%) 2 (3%)
Subcutaneous Tissue, Myxosarcoma 1 (2%)
Subcutaneous Tissue, Neurofibroma 1 (3%)
Subcutaneous Tissue, Neurofibrosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 50MG/KG 100MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (28) (60)
Femur, Osteosarcoma 1 (2%)
Vertebra, Osteosarcoma 1 (2%)
Skeletal Muscle (1) (2)
Diaphragm, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (27) (60)
Carcinoma, Extension 1 (2%)
Glioma Benign 1 (2%)
Oligodendroglioma Benign 1 (4%)
Cerebrum, Glioma Benign 1 (2%)
Peripheral Nerve (1)
Schwannoma Malignant 1 (100%)
Spinal Cord (3)
Schwannoma Malignant 1 (33%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60)
Adenocarcinoma, Metastatic, Salivary Glands 1 (2%)
Alveolar/Bronchiolar Adenoma 2 (3%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Sarcoma, Metastatic, Salivary Glands 1 (2%)
Schwannoma Malignant, Metastatic, Peripheral
Nerve 1 (2%)
Pleura, Mediastinum, Alveolar/Bronchiolar
Carcinoma, Metastatic, Lung 1 (2%)
Pleura, Mediastinum, Thymoma Malignant,
Metastatic, Thymus 1 (2%)
Nose (58) (59) (59)
Chondroma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Adenoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 50MG/KG 100MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (59)
Osteosarcoma, Metastatic, Bone 1 (2%)
Sarcoma 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%)
Urinary Bladder (59) (27) (59)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60)
Leukemia Mononuclear 13 (22%) 11 (18%) 12 (20%)
Mesothelioma Malignant 2 (3%) 3 (5%) 4 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05041-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 09/05/94
Route: GAVAGE Time: 13:16:48
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 50MG/KG 100MG/KG
MALE LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 60 57 52
Total Primary Neoplasms 159 128 121
Total Animals with Benign Neoplasms 59 56 51
Total Benign Neoplasms 122 96 95
Total Animals with Malignant Neoplasms 30 28 21
Total Malignant Neoplasms 37 31 26
Total Animals with Metastatic Neoplasms 3 5
Total Metastatic Neoplasm 6 15
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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