TR 373 Rat Pathology Tables
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
Facility: Microbiological Associates
Chemical CAS #: 108-30-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 6| 7| 7| 6| 5| 7| 7| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 9| 7| 0| 1| 2| 4| 0| 2| 2| 2| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 0| 4|
| 9| 3| 9| 5| 6| 4| 1| 9| 0| 7| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Regeneration | |
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + A + + + + + + + + + +|
Inflammation, Acute | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M A + + + + + + + A + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + M + + + + A + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + M + + + + A + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus, Multiple | X X X X X X X X |
Cytologic Alterations | X |
Cytologic Alterations, Multiple | |
Fibrosis, Focal | 2 2 2 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic | 2 1 2 2 2 1 2 |
Necrosis, Focal | |
Vacuolization Cytoplasmic | 2 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 2 |
Centrilobular, Vacuolization | |
Cytoplasmic | 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Inflammation, Chronic | |
Acinus, Atrophy, Diffuse | 4 |
Acinus, Atrophy, Focal | 1 1 1 1 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + M + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic | 1 1 2 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + M + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 6| 7| 7| 6| 5| 7| 7| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 9| 7| 0| 1| 2| 4| 0| 2| 2| 2| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 0| 4|
| 9| 3| 9| 5| 6| 4| 1| 9| 0| 7| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + |
Foreign Body | 2 |
Aorta, Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 2 2 1 2 1 1 2 1 1 2 2 |
Epicardium, Inflammation, Chronic | |
Active | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 1 |
Necrosis, Focal | 2 |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 3 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + M + M + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Concretion | |
Pars Distalis, Cyst | 1 |
Pars Distalis, Degeneration, Focal | 2 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + M + M + + + M M + + + + M + M M M + + + +|
Dilatation | 2 2 |
Hyperplasia | 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Endometrium, Hyperplasia, Cystic | 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 6| 7| 7| 6| 5| 7| 7| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 9| 7| 0| 1| 2| 4| 0| 2| 2| 2| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 0| 4|
| 9| 3| 9| 5| 6| 4| 1| 9| 0| 7| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hyperplasia, Reticulum Cell | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + M + + + + + + + + M + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2|
Pigmentation | 1 1 3 1 1 |
__________________________________________________________________________|
Thymus | M + + M + + + + M + + + + + + + + + + M M + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Femur, Hyperostosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Thrombosis, Focal | 2 |
Thalamus, Compression | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Foreign Body | 2 |
Hemorrhage | 2 |
Hyperplasia, Adenomatous | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1|
Inflammation, Acute | 3 |
Alveolar Epithelium, Hyperplasia | |
Mediastinum, Foreign Body | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 6| 7| 7| 6| 5| 7| 7| 7| 5| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 9| 7| 0| 1| 2| 4| 0| 2| 2| 2| 1| 6| 2| 2| 2| 2| 2| 3| 3| 3| 0| 4|
| 9| 3| 9| 5| 6| 4| 1| 9| 0| 7| 9| 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mediastinum, Inflammation, Acute | |
Mediastinum, Inflammation, Chronic | |
Active | 4 |
Pleura, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sinus, Foreign Body | |
Sinus, Fungus | |
Sinus, Inflammation, Acute | |
Turbinate, Inflammation, Chronic | 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | A + |
Abscess | |
Lens Capsule, Cataract | |
Retina, Atrophy | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Mineralization | |
Nephropathy | 1 1 1 1 1 1 1 |
Papilla, Necrosis | 3 |
Pelvis, Dilatation | 3 |
Pelvis, Mineralization | 2 1 1 |
Renal Tubule, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Urinary Bladder | + + + + M + M + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 0| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 3| 3| 1| 1| 7| 3| 3| 1| 1| 3| 3| 3| 3| 2| 3| 3| 0| 5| 7| 3| 3| 0| 4| 9|
| 6| 0| 0| 5| 6| 0| 0| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0| 6| 3| 7| 0| 0| 5| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Regeneration | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + M + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + + + A +|
Inflammation, Acute | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + M + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + M + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus, Multiple | X X X X X X X X X X X X X |
Cytologic Alterations | |
Cytologic Alterations, Multiple | X |
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic | 2 2 2 1 2 2 1 1 |
Necrosis, Focal | |
Vacuolization Cytoplasmic | 1 3 2 4 |
Bile Duct, Hyperplasia | 2 1 2 1 2 2 1 |
Centrilobular, Vacuolization | |
Cytoplasmic | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Inflammation, Chronic | 1 |
Acinus, Atrophy, Diffuse | 3 |
Acinus, Atrophy, Focal | 1 1 1 |
Acinus, Hyperplasia | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 0| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 3| 3| 1| 1| 7| 3| 3| 1| 1| 3| 3| 3| 3| 2| 3| 3| 0| 5| 7| 3| 3| 0| 4| 9|
| 6| 0| 0| 5| 6| 0| 0| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0| 6| 3| 7| 0| 0| 5| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | |
Foreign Body | |
Aorta, Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1|
Epicardium, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 2 2 |
Necrosis, Focal | 2 |
Vacuolization Cytoplasmic, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M M + M + + + + + + + + M + + + + + + M M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 1 2 2 |
Pars Distalis, Concretion | 2 |
Pars Distalis, Cyst | 2 1 |
Pars Distalis, Degeneration, Focal | |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M M + + + M + M + M M + + M + + M + + + M M|
Dilatation | |
Hyperplasia | |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + M|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hemorrhage | |
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 0| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 3| 3| 1| 1| 7| 3| 3| 1| 1| 3| 3| 3| 3| 2| 3| 3| 0| 5| 7| 3| 3| 0| 4| 9|
| 6| 0| 0| 5| 6| 0| 0| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0| 6| 3| 7| 0| 0| 5| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 1 |
Pigmentation | 3 1 |
__________________________________________________________________________|
Thymus | M + M + + + + + + + + + + + + + + M + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 2 3 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Femur, Hyperostosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Thrombosis, Focal | |
Thalamus, Compression | 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Foreign Body | |
Hemorrhage | 2 |
Hyperplasia, Adenomatous | 1 2 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Acute | |
Alveolar Epithelium, Hyperplasia | 3 |
Mediastinum, Foreign Body | 2 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5| 0| 7| 7| 7| 6| 4|
DAY ON TEST | 2| 3| 3| 1| 1| 7| 3| 3| 1| 1| 3| 3| 3| 3| 2| 3| 3| 0| 5| 7| 3| 3| 0| 4| 9|
| 6| 0| 0| 5| 6| 0| 0| 0| 9| 1| 0| 0| 0| 0| 0| 0| 0| 6| 3| 7| 0| 0| 5| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
CONTROL | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mediastinum, Inflammation, Acute | 4 |
Mediastinum, Inflammation, Chronic | |
Active | |
Pleura, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sinus, Foreign Body | 2 |
Sinus, Fungus | 2 |
Sinus, Inflammation, Acute | 1 2 |
Turbinate, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
Abscess | 4 |
Lens Capsule, Cataract | 2 |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Mineralization | 1 |
Nephropathy | 1 1 1 1 1 2 1 1 1 |
Papilla, Necrosis | |
Pelvis, Dilatation | |
Pelvis, Mineralization | 2 |
Renal Tubule, Vacuolization | |
Cytoplasmic | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 0| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 6| 7| 0| 2| 3| 3| 3| 0| | |
| 0| 0| 3| 9| 9| 3| 0| 0| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Muscularis, Regeneration | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + A + + + + A | 56 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + A | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + A | 55 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + A | 53 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + + A | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + A | 55 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + A | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + A | 53 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 1.0|
Basophilic Focus, Multiple | X X X X X X | 27 |
Cytologic Alterations | | 1 |
Cytologic Alterations, Multiple | | 1 |
Fibrosis, Focal | 1 | 6 1.7|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X | 5 |
Inflammation, Chronic | 2 | 16 1.7|
Necrosis, Focal | 1 | 1 1.0|
Vacuolization Cytoplasmic | 1 | 6 2.2|
Bile Duct, Hyperplasia | 1 2 2 2 1 | 19 1.4|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 5 2.0|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Fat, Necrosis | | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + A + + + + + | 59 |
Ectopic Tissue | | 1 |
Inflammation, Chronic | | 1 1.0|
Acinus, Atrophy, Diffuse | | 2 3.5|
Acinus, Atrophy, Focal | 1 1 2 | 10 1.1|
Acinus, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + A + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + A + + + + + | 58 |
Foreign Body | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 0| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 6| 7| 0| 2| 3| 3| 3| 0| | |
| 0| 0| 3| 9| 9| 3| 0| 0| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 3 1.3|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + | 58 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Foreign Body | | 1 2.0|
Aorta, Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 1 1 1 1 1 1 | 38 1.2|
Epicardium, Inflammation, Chronic | | |
Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | | 4 1.8|
Necrosis, Focal | | 2 2.0|
Vacuolization Cytoplasmic, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
Hyperplasia | 1 2 | 11 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M A M + + + + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | 2 1 | 9 1.8|
Pars Distalis, Concretion | | 1 2.0|
Pars Distalis, Cyst | 2 | 4 1.5|
Pars Distalis, Degeneration, Focal | | 1 2.0|
Pars Distalis, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + A + + + + + | 59 |
C-Cell, Hyperplasia | | 8 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 0| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 6| 7| 0| 2| 3| 3| 3| 0| | |
| 0| 0| 3| 9| 9| 3| 0| 0| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + A + + + + + | 39 |
Dilatation | | 2 2.0|
Hyperplasia | | 1 2.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Cyst | 2 | 4 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Hemorrhage | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia | 2 | 3 2.7|
Hyperplasia, Reticulum Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + M + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + M | 54 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + | 59 |
Edema | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + A + + + + + | 59 |
Hematopoietic Cell Proliferation | 2 2 | 6 1.8|
Pigmentation | 2 2 1 | 10 1.6|
__________________________________________________________________________|____________|
Thymus | + + M + + M + + + + | 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + | 59 |
Dilatation | 2 | 8 2.4|
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Cranium, Femur, Hyperostosis | | 2 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Abscess | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 0| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 6| 7| 0| 2| 3| 3| 3| 0| | |
| 0| 0| 3| 9| 9| 3| 0| 0| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Thrombosis, Focal | | 1 2.0|
Thalamus, Compression | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + M + | 58 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 2 2.5|
Foreign Body | 2 | 2 2.0|
Hemorrhage | 2 | 3 2.0|
Hyperplasia, Adenomatous | 2 | 4 1.8|
Infiltration Cellular, Histiocyte | 1 1 1 | 23 1.0|
Inflammation, Acute | 3 | 2 3.0|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
Mediastinum, Foreign Body | | 1 2.0|
Mediastinum, Inflammation, Acute | | 1 4.0|
Mediastinum, Inflammation, Chronic | | |
Active | | 1 4.0|
Pleura, Inflammation, Chronic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + A + + + + + | 59 |
Sinus, Foreign Body | | 1 2.0|
Sinus, Fungus | | 1 2.0|
Sinus, Inflammation, Acute | | 2 1.5|
Turbinate, Inflammation, Chronic | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 4 |
Abscess | | 1 4.0|
Lens Capsule, Cataract | | 1 2.0|
Retina, Atrophy | 3 | 3 2.7|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 1 1.0|
Mineralization | | 1 1.0|
Nephropathy | 1 1 1 1 | 20 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 0| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 6| 7| 0| 2| 3| 3| 3| 0| | |
| 0| 0| 3| 9| 9| 3| 0| 0| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
CONTROL | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Papilla, Necrosis | | 1 3.0|
Pelvis, Dilatation | | 1 3.0|
Pelvis, Mineralization | 2 | 5 1.6|
Renal Tubule, Vacuolization | | |
Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + M + + + | 56 |
Angiectasis | | 1 2.0|
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 5| 4| 0| 0| 7| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 6| 6| 1| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 0| 0| 0| 3| 1| 1| 0| 0| 3| 3| 3| 0| 1| 3| 9| 8| 6| 0| 3| 3| 3| 3| 3|
| 1| 0| 1| 5| 2| 1| 3| 0| 9| 9| 1| 1| 1| 5| 2| 1| 1| 4| 9| 2| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + |
Hemorrhage | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + M M M M M M + M + + + + M |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + M M M M M M + M + + + + M |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + M M M M M M + M + + + + M |
__________________________________________________________________________|
Intestine Small, Jejunum | + + M M M M M M + M + + + + M |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | X |
Basophilic Focus, Multiple | X X X X |
Congestion | 3 |
Cytologic Alterations | |
Cytologic Alterations, Multiple | X |
Fibrosis, Focal | 2 1 1 |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Nodular | 2 |
Inflammation, Chronic | 1 2 1 2 |
Necrosis, Focal | |
Necrosis, Multifocal | 3 2 |
Vacuolization Cytoplasmic | 3 |
Bile Duct, Hyperplasia | |
Centrilobular, Fibrosis, Multifocal | 3 |
Centrilobular, Necrosis | 2 |
Centrilobular, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + |
Hemorrhage | 2 |
Inflammation, Chronic | 3 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + |
Inflammation, Acute | |
Acinus, Atrophy, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + |
Edema | 2 |
Inflammation, Acute | 1 |
Inflammation, Chronic | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + |
Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 5| 4| 0| 0| 7| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 6| 6| 1| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 0| 0| 0| 3| 1| 1| 0| 0| 3| 3| 3| 0| 1| 3| 9| 8| 6| 0| 3| 3| 3| 3| 3|
| 1| 0| 1| 5| 2| 1| 3| 0| 9| 9| 1| 1| 1| 5| 2| 1| 1| 4| 9| 2| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 1 |
Foreign Body | |
Atrium, Thrombosis | |
Epicardium, Inflammation, Chronic | 2 2 |
Epicardium, Necrosis | 2 1 |
Pericardium, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + |
Congestion | 3 |
Hypertrophy, Focal | 4 |
Metaplasia, Osseous | |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M + M M + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 2|
Pars Distalis, Hyperplasia | 3 |
Pars Distalis, Pigmentation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M M M M M M M + M M + + M M + |
Dilatation | |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + |
Cyst | 3 |
Hemorrhage | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + |
Hemorrhage | 3 |
Endometrium, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 5| 4| 0| 0| 7| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 6| 6| 1| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 0| 0| 0| 3| 1| 1| 0| 0| 3| 3| 3| 0| 1| 3| 9| 8| 6| 0| 3| 3| 3| 3| 3|
| 1| 0| 1| 5| 2| 1| 3| 0| 9| 9| 1| 1| 1| 5| 2| 1| 1| 4| 9| 2| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Reticulum Cell | 4 |
Hypoplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + |
Mediastinal, Giant Cell, Multiple | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + |
Hemorrhage | 2 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + M + |
Edema | |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + M + + + + + + + + + + |
Congestion | |
Hematopoietic Cell Proliferation | 2 2 |
Infarct | |
Pigmentation | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + |
Necrosis | 4 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + M + + + M + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + |
Cranium, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + |
Hemorrhage | 2 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + |
Necrosis | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + |
Congestion | 2 3 2 3 |
Edema | |
Foreign Body | 2 3 4 |
Hemorrhage | 1 4 |
Hyperplasia, Adenomatous | 1 |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Acute | 3 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 5| 4| 0| 0| 7| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 6| 6| 1| 0| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 0| 0| 0| 3| 1| 1| 0| 0| 3| 3| 3| 0| 1| 3| 9| 8| 6| 0| 3| 3| 3| 3| 3|
| 1| 0| 1| 5| 2| 1| 3| 0| 9| 9| 1| 1| 1| 5| 2| 1| 1| 4| 9| 2| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Granulomatous | |
Pigmentation | 1 |
Pleura, Foreign Body | 2 |
Pleura, Inflammation, Acute | |
Pleura, Necrosis | 2 2 3 2 |
__________________________________________________________________________|
Nose | + + + M M + M M M M + + + + M + + + + M + + + + +|
Foreign Body | |
Sinus, Foreign Body | |
Sinus, Inflammation, Acute | |
Turbinate, Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + |
Necrosis | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Lens Capsule, Cataract | 2 3 |
Retina, Atrophy | 3 3 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 |
Nephropathy | 1 1 2 1 |
Pigmentation | |
Pelvis, Mineralization | |
Renal Tubule, Atrophy | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + M + + M + + + + + |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 7| 6| 6| 5| 4| 7| 7| 7| 6| 7| 7| 7| 6| 0| 7| 7| 7| 6| 6|
DAY ON TEST | 1| 3| 3| 8| 9| 2| 3| 7| 0| 4| 7| 3| 3| 3| 2| 2| 3| 3| 0| 1| 3| 3| 3| 9| 0|
| 7| 1| 1| 9| 9| 3| 2| 7| 6| 1| 1| 2| 2| 2| 0| 3| 2| 2| 3| 1| 2| 2| 2| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Basophilic Focus, Multiple | X X X X X X X X X X |
Congestion | 2 |
Cytologic Alterations | X |
Cytologic Alterations, Multiple | |
Fibrosis, Focal | 1 1 2 1 1 2 1|
Hepatodiaphragmatic Nodule | X X X X X X|
Hyperplasia, Nodular | 2 2 |
Inflammation, Chronic | 1 1 1 1 1 1 2 |
Necrosis, Focal | 1 |
Necrosis, Multifocal | 4 |
Vacuolization Cytoplasmic | 2|
Bile Duct, Hyperplasia | 1 2 1 1 |
Centrilobular, Fibrosis, Multifocal | |
Centrilobular, Necrosis | 2 |
Centrilobular, Vacuolization | |
Cytoplasmic | 2 |
__________________________________________________________________________|
Mesentery | + |
Hemorrhage | |
Inflammation, Chronic | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + +|
Inflammation, Acute | |
Acinus, Atrophy, Focal | 2 3 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + M + + + + +|
Edema | |
Inflammation, Acute | 2|
Inflammation, Chronic | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 7| 6| 6| 5| 4| 7| 7| 7| 6| 7| 7| 7| 6| 0| 7| 7| 7| 6| 6|
DAY ON TEST | 1| 3| 3| 8| 9| 2| 3| 7| 0| 4| 7| 3| 3| 3| 2| 2| 3| 3| 0| 1| 3| 3| 3| 9| 0|
| 7| 1| 1| 9| 9| 3| 2| 7| 6| 1| 1| 2| 2| 2| 0| 3| 2| 2| 3| 1| 2| 2| 2| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 2 1 |
Foreign Body | |
Atrium, Thrombosis | 2 |
Epicardium, Inflammation, Chronic | |
Epicardium, Necrosis | |
Pericardium, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + M + + + + +|
Congestion | |
Hypertrophy, Focal | |
Metaplasia, Osseous | 2 |
Necrosis, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + M + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 3 |
Pars Distalis, Hyperplasia | 2 |
Pars Distalis, Pigmentation | 1 |
__________________________________________________________________________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + M + + M + + + M M + M + + M|
Dilatation | 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 3 |
Hemorrhage | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Endometrium, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 7| 6| 6| 5| 4| 7| 7| 7| 6| 7| 7| 7| 6| 0| 7| 7| 7| 6| 6|
DAY ON TEST | 1| 3| 3| 8| 9| 2| 3| 7| 0| 4| 7| 3| 3| 3| 2| 2| 3| 3| 0| 1| 3| 3| 3| 9| 0|
| 7| 1| 1| 9| 9| 3| 2| 7| 6| 1| 1| 2| 2| 2| 0| 3| 2| 2| 3| 1| 2| 2| 2| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Reticulum Cell | 4 |
Hypoplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Giant Cell, Multiple | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | |
Infarct | 2 |
Pigmentation | 2 1 2 1 1 |
__________________________________________________________________________|
Thymus | + + + + M + M + + + + M + + + + + + + M + +|
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + M +|
Dilatation | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + M + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 2 |
Foreign Body | 3 3 2 |
Hemorrhage | 2 |
Hyperplasia, Adenomatous | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 |
Inflammation, Acute | 3 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 7| 6| 6| 5| 4| 7| 7| 7| 6| 7| 7| 7| 6| 0| 7| 7| 7| 6| 6|
DAY ON TEST | 1| 3| 3| 8| 9| 2| 3| 7| 0| 4| 7| 3| 3| 3| 2| 2| 3| 3| 0| 1| 3| 3| 3| 9| 0|
| 7| 1| 1| 9| 9| 3| 2| 7| 6| 1| 1| 2| 2| 2| 0| 3| 2| 2| 3| 1| 2| 2| 2| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
50 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Granulomatous | 4 |
Pigmentation | |
Pleura, Foreign Body | |
Pleura, Inflammation, Acute | |
Pleura, Necrosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + M + + + + +|
Foreign Body | 2 |
Sinus, Foreign Body | 2 3 |
Sinus, Inflammation, Acute | 2 1 2 2 2 2 2|
Turbinate, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Trachea | + + M + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Lens Capsule, Cataract | 2 |
Retina, Atrophy | 2 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
Nephropathy | 1 1 1 1 2 1 1 |
Pigmentation | 1 2 |
Pelvis, Mineralization | 1 |
Renal Tubule, Atrophy | |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 6| 7| 7| 0| | |
DAY ON TEST | 2| 3| 3| 2| 8| 3| 4| 3| 3| 0| | |
| 3| 2| 2| 3| 7| 2| 2| 2| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
50 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 45 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + M | 35 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M | 35 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + M | 35 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + M | 35 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 52 |
Basophilic Focus | X | 3 |
Basophilic Focus, Multiple | X X | 16 |
Congestion | | 2 2.5|
Cytologic Alterations | | 1 |
Cytologic Alterations, Multiple | | 1 |
Fibrosis, Focal | 2 1 | 12 1.3|
Hepatodiaphragmatic Nodule | X X X | 12 |
Hyperplasia, Nodular | | 3 2.0|
Inflammation, Chronic | 1 2 2 2 | 15 1.4|
Necrosis, Focal | | 1 1.0|
Necrosis, Multifocal | | 3 3.0|
Vacuolization Cytoplasmic | 2 | 3 2.3|
Bile Duct, Hyperplasia | 1 1 | 6 1.2|
Centrilobular, Fibrosis, Multifocal | | 1 3.0|
Centrilobular, Necrosis | 2 | 3 2.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Fat, Necrosis | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 44 |
Inflammation, Acute | 2 | 1 2.0|
Acinus, Atrophy, Focal | | 5 1.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 44 |
Edema | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 6| 7| 7| 0| | |
DAY ON TEST | 2| 3| 3| 2| 8| 3| 4| 3| 3| 0| | |
| 3| 2| 2| 3| 7| 2| 2| 2| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
50 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Acute | | 2 1.5|
Inflammation, Chronic | 2 | 1 2.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 45 |
Inflammation, Acute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 45 |
Cardiomyopathy | 2 2 1 1 1 | 18 1.3|
Foreign Body | 3 | 1 3.0|
Atrium, Thrombosis | | 1 2.0|
Epicardium, Inflammation, Chronic | | 2 2.0|
Epicardium, Necrosis | | 2 1.5|
Pericardium, Inflammation, Acute | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 45 |
Congestion | | 1 3.0|
Hypertrophy, Focal | | 1 4.0|
Metaplasia, Osseous | | 1 2.0|
Necrosis, Focal | 3 2 | 5 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + | 43 |
Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + | 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 55 |
Pars Distalis, Angiectasis | 4 | 9 2.3|
Pars Distalis, Hyperplasia | | 2 2.5|
Pars Distalis, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 45 |
C-Cell, Hyperplasia | | 4 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + M | 27 |
Dilatation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 6| 7| 7| 0| | |
DAY ON TEST | 2| 3| 3| 2| 8| 3| 4| 3| 3| 0| | |
| 3| 2| 2| 3| 7| 2| 2| 2| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
50 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + | 44 |
Cyst | | 4 2.5|
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 48 |
Hemorrhage | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 45 |
Hyperplasia, Reticulum Cell | | 2 4.0|
Hypoplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 45 |
Mediastinal, Giant Cell, Multiple | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + | 43 |
Hemorrhage | | 2 2.5|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 43 |
Edema | 2 | 2 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 46 |
Congestion | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 3 1.7|
Infarct | | 1 2.0|
Pigmentation | 2 | 7 1.4|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 41 |
Necrosis | | 2 3.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 55 |
Dilatation | 1 2 | 4 1.8|
Hyperplasia | 1 | 3 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 44 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 45 |
Cranium, Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 6| 7| 7| 0| | |
DAY ON TEST | 2| 3| 3| 2| 8| 3| 4| 3| 3| 0| | |
| 3| 2| 2| 3| 7| 2| 2| 2| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
50 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 45 |
Hemorrhage | 2 | 3 2.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + | 44 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 49 |
Congestion | 2 | 5 2.4|
Edema | | 1 2.0|
Foreign Body | 2 | 7 2.7|
Hemorrhage | | 3 2.3|
Hyperplasia, Adenomatous | 1 2 | 4 1.3|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 | 13 1.0|
Inflammation, Acute | 3 | 3 3.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Granulomatous | | 1 4.0|
Pigmentation | | 1 1.0|
Pleura, Foreign Body | | 1 2.0|
Pleura, Inflammation, Acute | 3 | 1 3.0|
Pleura, Necrosis | | 5 2.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + M | 50 |
Foreign Body | | 1 2.0|
Sinus, Foreign Body | | 2 2.5|
Sinus, Inflammation, Acute | | 7 1.9|
Turbinate, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 44 |
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 8 |
Lens Capsule, Cataract | 3 | 4 2.5|
Retina, Atrophy | 3 2 | 5 2.6|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 59 |
Congestion | | 1 2.0|
Hemorrhage | | 1 2.0|
Nephropathy | 1 1 2 1 | 15 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 7| 6| 7| 7| 0| | |
DAY ON TEST | 2| 3| 3| 2| 8| 3| 4| 3| 3| 0| | |
| 3| 2| 2| 3| 7| 2| 2| 2| 2| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
50 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
LOW FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Pigmentation | | 2 1.5|
Pelvis, Mineralization | 2 1 | 3 1.3|
Renal Tubule, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 41 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 0| 7| 7| 6| 3| 1| 7| 1| 1| 3| 3|
DAY ON TEST | 3| 1| 0| 3| 0| 3| 2| 1| 6| 2| 3| 3| 3| 3| 0| 3| 2| 2| 5| 9| 3| 7| 7| 3| 6|
| 1| 9| 6| 2| 5| 2| 0| 1| 3| 5| 2| 2| 2| 2| 9| 2| 0| 5| 3| 8| 2| 6| 0| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Adventitia, Fibrosis | |
Muscularis, Regeneration | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X X X X X |
Congestion | 2 |
Cytologic Alterations | X X X X X X |
Fibrosis, Focal | 1 2 2 2 1|
Hepatodiaphragmatic Nodule | X X X X X X|
Hyperplasia, Nodular | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 1 1 2 2 2 2 |
Necrosis, Multifocal | 2 |
Vacuolization Cytoplasmic | 4 2 |
Bile Duct, Hyperplasia | 2 1 |
Centrilobular, Congestion | 2 |
Centrilobular, Vacuolization | |
Cytoplasmic | 3 |
Hepatocyte, Inclusion Body | |
Intranuclear | 2|
__________________________________________________________________________|
Mesentery | + + |
Hemorrhage | 3 |
Inflammation, Chronic | 2 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | 2 |
Inflammation, Chronic | 1 |
Acinus, Atrophy, Focal | 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +|
Erosion, Acute | |
Hyperplasia, Focal | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 0| 7| 7| 6| 3| 1| 7| 1| 1| 3| 3|
DAY ON TEST | 3| 1| 0| 3| 0| 3| 2| 1| 6| 2| 3| 3| 3| 3| 0| 3| 2| 2| 5| 9| 3| 7| 7| 3| 6|
| 1| 9| 6| 2| 5| 2| 0| 1| 3| 5| 2| 2| 2| 2| 9| 2| 0| 5| 3| 8| 2| 6| 0| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +|
Epithelium, Cyst | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 2 1 1 1 1 |
Atrium, Thrombosis | |
Coronary Artery, Inflammation, | |
Chronic | |
Epicardium, Foreign Body | 2 2 |
Epicardium, Inflammation, Acute | |
Epicardium, Inflammation, Chronic | |
Active | 2 4 4 |
Epicardium, Necrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia | |
Hypertrophy | 3 |
Necrosis, Focal | |
Vacuolization Cytoplasmic, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + + + M + + + + M M +|
Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M + M + + M + + M + + + M + M + + M + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Pars Distalis, Angiectasis | 2 2 2 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Degeneration, Focal | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Dilatation | |
Inflammation, Acute | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 0| 7| 7| 6| 3| 1| 7| 1| 1| 3| 3|
DAY ON TEST | 3| 1| 0| 3| 0| 3| 2| 1| 6| 2| 3| 3| 3| 3| 0| 3| 2| 2| 5| 9| 3| 7| 7| 3| 6|
| 1| 9| 6| 2| 5| 2| 0| 1| 3| 5| 2| 2| 2| 2| 9| 2| 0| 5| 3| 8| 2| 6| 0| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 2 1 |
Congestion | |
Cyst | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
__________________________________________________________________________|
Vagina | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Foreign Body | 2 2 |
Mediastinal, Hemorrhage | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + M + +|
Congestion | |
Cyst | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hemorrhage | 3 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic | |
Pigmentation | 2 2 2 1 1 |
__________________________________________________________________________|
Thymus | + M + + M + M M + + + + + + + + + + + + + + + + M|
Hemorrhage | |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Acute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 0| 7| 7| 6| 3| 1| 7| 1| 1| 3| 3|
DAY ON TEST | 3| 1| 0| 3| 0| 3| 2| 1| 6| 2| 3| 3| 3| 3| 0| 3| 2| 2| 5| 9| 3| 7| 7| 3| 6|
| 1| 9| 6| 2| 5| 2| 0| 1| 3| 5| 2| 2| 2| 2| 9| 2| 0| 5| 3| 8| 2| 6| 0| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis, Multifocal | 2 |
Meninges, Infiltration Cellular, | |
Lymphocyte | |
Pons, Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 |
Edema | |
Fibrosis, Focal | |
Foreign Body | 2 2 2 2 |
Hemorrhage | 3 |
Hyperplasia, Adenomatous | 2 1 |
Infiltration Cellular, Histiocyte | 2 1 1 1 1 1 1 2 1 1|
Inflammation, Acute | 3 |
Inflammation, Chronic | |
Pigmentation | 1 |
Bronchiole, Foreign Body | |
Bronchiole, Inflammation, Acute | 3 |
Bronchiole, Inflammation, Subacute | 3 |
Mediastinum, Foreign Body | 2 |
Mediastinum, Hemorrhage | 4 |
Mediastinum, Inflammation, Chronic | |
Active | 3 4 |
Mediastinum, Necrosis | |
Pleura, Fibrosis | 2 |
Pleura, Inflammation, Chronic Active | 2 2 |
Pleura, Necrosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + A + + + + + + + + + +|
Sinus, Foreign Body | 2 |
Sinus, Fungus | 2 |
Sinus, Hemorrhage | |
Sinus, Inflammation, Acute | 2 2 3 2 |
Turbinate, Inflammation, Subacute | 2 2 |
Turbinate, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 1 |
Necrosis | 4 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 5| 2| 7| 7| 7| 7| 0| 7| 7| 6| 3| 1| 7| 1| 1| 3| 3|
DAY ON TEST | 3| 1| 0| 3| 0| 3| 2| 1| 6| 2| 3| 3| 3| 3| 0| 3| 2| 2| 5| 9| 3| 7| 7| 3| 6|
| 1| 9| 6| 2| 5| 2| 0| 1| 3| 5| 2| 2| 2| 2| 9| 2| 0| 5| 3| 8| 2| 6| 0| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | + + |
Lens Capsule, Cataract | 2 2 |
Retina, Atrophy | 3 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 1 1 1 1 1 |
Pigmentation | 3 |
Pelvis, Mineralization | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 6| 1| 0| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 6| 6| 2|
DAY ON TEST | 3| 7| 1| 0| 0| 3| 3| 3| 3| 0| 3| 3| 2| 2| 3| 3| 3| 7| 8| 8| 3| 3| 6| 0| 0|
| 2| 4| 1| 9| 5| 2| 2| 2| 2| 3| 2| 2| 6| 6| 2| 2| 2| 8| 6| 3| 2| 2| 3| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4|
Adventitia, Fibrosis | 4|
Muscularis, Regeneration | 2 |
__________________________________________________________________________|
Intestine Large | + + + + A + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + M M A + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M M A + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + A + M A + + + + A + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + M A + + + + A + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A M M A + + + + A + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A M M A + + + + A + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | X X X X X X X |
Congestion | 2 2 |
Cytologic Alterations | |
Fibrosis, Focal | 2 2 2 2 1 |
Hepatodiaphragmatic Nodule | X X X X X X X |
Hyperplasia, Nodular | |
Inflammation, Acute | |
Inflammation, Chronic | 1 2 2 1 2 2 |
Necrosis, Multifocal | |
Vacuolization Cytoplasmic | 2 3 |
Bile Duct, Hyperplasia | 1 1 2 1 2 2 2 |
Centrilobular, Congestion | |
Centrilobular, Vacuolization | |
Cytoplasmic | |
Hepatocyte, Inclusion Body | |
Intranuclear | |
__________________________________________________________________________|
Mesentery | |
Hemorrhage | |
Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Hemorrhage | |
Inflammation, Chronic | |
Acinus, Atrophy, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
Erosion, Acute | 2 |
Hyperplasia, Focal | 2 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 6| 1| 0| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 6| 6| 2|
DAY ON TEST | 3| 7| 1| 0| 0| 3| 3| 3| 3| 0| 3| 3| 2| 2| 3| 3| 3| 7| 8| 8| 3| 3| 6| 0| 0|
| 2| 4| 1| 9| 5| 2| 2| 2| 2| 3| 2| 2| 6| 6| 2| 2| 2| 8| 6| 3| 2| 2| 3| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + A + + + + + + + + + + + + + + +|
Epithelium, Cyst | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 1 2 1 |
Atrium, Thrombosis | |
Coronary Artery, Inflammation, | |
Chronic | |
Epicardium, Foreign Body | |
Epicardium, Inflammation, Acute | 2 |
Epicardium, Inflammation, Chronic | |
Active | |
Epicardium, Necrosis | 3 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia | 2 |
Hypertrophy | |
Necrosis, Focal | 2 |
Vacuolization Cytoplasmic, Focal | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 1 1 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M + M + + + + + + + + + + + + M + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Degeneration, Focal | 1 |
Pars Distalis, Hyperplasia | 1 3 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + + M + + + + + + M M M M|
Dilatation | |
Inflammation, Acute | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 6| 1| 0| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 6| 6| 2|
DAY ON TEST | 3| 7| 1| 0| 0| 3| 3| 3| 3| 0| 3| 3| 2| 2| 3| 3| 3| 7| 8| 8| 3| 3| 6| 0| 0|
| 2| 4| 1| 9| 5| 2| 2| 2| 2| 3| 2| 2| 6| 6| 2| 2| 2| 8| 6| 3| 2| 2| 3| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | |
Congestion | |
Cyst | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 |
__________________________________________________________________________|
Vagina | + |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Hyperplasia, Reticulum Cell | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Foreign Body | |
Mediastinal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M M|
Congestion | 2 |
Cyst | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | 2 |
Pigmentation | 2 1 2|
__________________________________________________________________________|
Thymus | M + + + + + + + + + M + + + + + + + + + M + + + +|
Hemorrhage | 2 2|
Necrosis | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 6| 1| 0| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 6| 6| 2|
DAY ON TEST | 3| 7| 1| 0| 0| 3| 3| 3| 3| 0| 3| 3| 2| 2| 3| 3| 3| 7| 8| 8| 3| 3| 6| 0| 0|
| 2| 4| 1| 9| 5| 2| 2| 2| 2| 3| 2| 2| 6| 6| 2| 2| 2| 8| 6| 3| 2| 2| 3| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis, Multifocal | |
Meninges, Infiltration Cellular, | |
Lymphocyte | 2 |
Pons, Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 2 3 3 |
Edema | 2 |
Fibrosis, Focal | 1 |
Foreign Body | 2 1 2|
Hemorrhage | 2 |
Hyperplasia, Adenomatous | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 |
Pigmentation | 2 |
Bronchiole, Foreign Body | |
Bronchiole, Inflammation, Acute | |
Bronchiole, Inflammation, Subacute | |
Mediastinum, Foreign Body | |
Mediastinum, Hemorrhage | |
Mediastinum, Inflammation, Chronic | |
Active | 4 |
Mediastinum, Necrosis | 2 |
Pleura, Fibrosis | 4|
Pleura, Inflammation, Chronic Active | |
Pleura, Necrosis | 3 4 2 |
__________________________________________________________________________|
Nose | + + M M + + + + + + + + + + + + + + + + + + + + +|
Sinus, Foreign Body | 2 2 2|
Sinus, Fungus | 2 |
Sinus, Hemorrhage | |
Sinus, Inflammation, Acute | 2 2 2 |
Turbinate, Inflammation, Subacute | |
Turbinate, Necrosis | 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic | |
Necrosis | 4 4|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 6| 1| 0| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 2| 7| 7| 6| 6| 2|
DAY ON TEST | 3| 7| 1| 0| 0| 3| 3| 3| 3| 0| 3| 3| 2| 2| 3| 3| 3| 7| 8| 8| 3| 3| 6| 0| 0|
| 2| 4| 1| 9| 5| 2| 2| 2| 2| 3| 2| 2| 6| 6| 2| 2| 2| 8| 6| 3| 2| 2| 3| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
100MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | + |
Lens Capsule, Cataract | 2 |
Retina, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 2 1 1 |
Pigmentation | |
Pelvis, Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 4| 0| | |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 4| 1| 0| | |
| 2| 2| 9| 2| 2| 2| 2| 2| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Inflammation, Chronic | 2 1 | 3 2.3|
Adventitia, Fibrosis | | 1 4.0|
Muscularis, Regeneration | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + A + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + | 51 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus, Multiple | X X X X X X X | 25 |
Congestion | | 3 2.0|
Cytologic Alterations | | 6 |
Fibrosis, Focal | | 10 1.7|
Hepatodiaphragmatic Nodule | X | 14 |
Hyperplasia, Nodular | 2 | 1 2.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | 2 2 2 | 15 1.7|
Necrosis, Multifocal | 3 | 2 2.5|
Vacuolization Cytoplasmic | | 4 2.8|
Bile Duct, Hyperplasia | | 9 1.6|
Centrilobular, Congestion | | 1 2.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 1 3.0|
Hepatocyte, Inclusion Body | | |
Intranuclear | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Fat, Necrosis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + A + + + + + + + | 59 |
Cyst | | 1 1.0|
Hemorrhage | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Acinus, Atrophy, Focal | 1 | 5 1.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 4| 0| | |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 4| 1| 0| | |
| 2| 2| 9| 2| 2| 2| 2| 2| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + A + + + + + + + | 57 |
Erosion, Acute | | 1 2.0|
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + M + + + + A + + | 54 |
Epithelium, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 1 1 1 | 21 1.3|
Atrium, Thrombosis | 2 | 1 2.0|
Coronary Artery, Inflammation, | | |
Chronic | 2 | 1 2.0|
Epicardium, Foreign Body | | 2 2.0|
Epicardium, Inflammation, Acute | 1 | 2 1.5|
Epicardium, Inflammation, Chronic | | |
Active | | 3 3.3|
Epicardium, Necrosis | | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 59 |
Congestion | 2 | 2 2.0|
Hyperplasia | 3 | 2 2.5|
Hypertrophy | | 1 3.0|
Necrosis, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 3 2 | 6 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 54 |
Hyperplasia | | 9 1.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + + + + + | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Hemorrhage | | 1 2.0|
Pars Distalis, Angiectasis | 2 2 2 | 8 2.0|
Pars Distalis, Cyst | 2 | 3 2.0|
Pars Distalis, Degeneration, Focal | | 1 1.0|
Pars Distalis, Hyperplasia | 2 4 | 7 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 4| 0| | |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 4| 1| 0| | |
| 2| 2| 9| 2| 2| 2| 2| 2| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | | 5 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 53 |
Dilatation | 2 | 1 2.0|
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Atrophy | | 2 1.5|
Congestion | 3 2 | 2 2.5|
Cyst | | 2 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Congestion | 2 | 1 2.0|
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
Hyperplasia, Reticulum Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Foreign Body | | 2 2.0|
Mediastinal, Hemorrhage | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + | 55 |
Congestion | | 1 2.0|
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Hemorrhage | | 3 2.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Pigmentation | 2 | 9 1.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 52 |
Hemorrhage | | 2 2.0|
Necrosis | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 4| 0| | |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 4| 1| 0| | |
| 2| 2| 9| 2| 2| 2| 2| 2| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Dilatation | | 1 2.0|
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Inflammation, | | |
Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Thrombosis, Multifocal | | 1 2.0|
Meninges, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
Pons, Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 3 2 | 9 2.6|
Edema | 2 | 2 2.0|
Fibrosis, Focal | | 1 1.0|
Foreign Body | 2 | 8 1.9|
Hemorrhage | 2 | 3 2.3|
Hyperplasia, Adenomatous | 1 | 4 1.3|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 | 24 1.1|
Inflammation, Acute | 2 | 3 2.3|
Inflammation, Chronic | 2 | 2 2.0|
Pigmentation | | 2 1.5|
Bronchiole, Foreign Body | 2 | 1 2.0|
Bronchiole, Inflammation, Acute | 3 | 2 3.0|
Bronchiole, Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 4| 0| | |
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 4| 1| 0| | |
| 2| 2| 9| 2| 2| 2| 2| 2| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
100MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
HIGHFEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mediastinum, Foreign Body | | 1 2.0|
Mediastinum, Hemorrhage | | 1 4.0|
Mediastinum, Inflammation, Chronic | | |
Active | | 3 3.7|
Mediastinum, Necrosis | | 1 2.0|
Pleura, Fibrosis | 2 | 3 2.7|
Pleura, Inflammation, Chronic Active | | 2 2.0|
Pleura, Necrosis | 2 | 4 2.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 57 |
Sinus, Foreign Body | 3 | 5 2.2|
Sinus, Fungus | | 2 2.0|
Sinus, Hemorrhage | 2 | 1 2.0|
Sinus, Inflammation, Acute | 3 1 | 9 2.1|
Turbinate, Inflammation, Subacute | | 2 2.0|
Turbinate, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Necrosis | 4 | 5 3.8|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
Lens Capsule, Cataract | 2 | 4 2.0|
Retina, Atrophy | 2 | 4 2.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | 2 | 1 2.0|
Nephropathy | 1 | 9 1.1|
Pigmentation | | 1 3.0|
Pelvis, Mineralization | | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 1| 4| 2| 2| 2| 2| 7| 2| 2| 2| 4| 8| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|
| 9| 9| 9| 1| 9| 9| 9| 9| 9| 5| 9| 9| 9| 6| 1| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + A + +|
Foreign Body | |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X|
Basophilic Focus, Multiple | X X X 1 X |
Cytologic Alterations | X |
Cytologic Alterations, Multiple | X |
Fibrosis, Focal | 2 1 1 |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | 2|
Hyperplasia, Nodular | |
Inflammation, Chronic | 2 1 1 1 |
Necrosis, Focal | |
Necrosis, Multifocal | |
Vacuolization Cytoplasmic | 2 1 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 2 1 2 1 2 1 2 1 2 2 1 1 2 1 2 2 1 2 2|
Centrilobular, Necrosis | |
Centrilobular, Vacuolization | |
Cytoplasmic | 1 |
__________________________________________________________________________|
Mesentery | + + + + + +|
Inflammation, Chronic | |
Fat, Necrosis | 3 2 2 3 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | 1 2 1 1 1 1 2 1 2|
Acinus, Hyperplasia, Focal | |
Artery, Inflammation, Chronic | |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + M + + + + + + + + + + + M + +|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 1| 4| 2| 2| 2| 2| 7| 2| 2| 2| 4| 8| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|
| 9| 9| 9| 1| 9| 9| 9| 9| 9| 5| 9| 9| 9| 6| 1| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hemorrhage | |
Inflammation, Chronic | 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + M + + + + + + + A + +|
Edema | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 1 2 1 1 2 2 2 2 2 2 1 1 2 1 2 2 3|
Atrium, Thrombosis | 4 3 |
Epicardium, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy, Focal | |
Necrosis, Focal | |
Vacuolization Cytoplasmic, Focal | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 2 1 1 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + M M + + + M + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + M M + +|
Hemorrhage | |
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | 1 |
C-Cell, Hyperplasia | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 1| 4| 2| 2| 2| 2| 7| 2| 2| 2| 4| 8| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|
| 9| 9| 9| 1| 9| 9| 9| 9| 9| 5| 9| 9| 9| 6| 1| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Serosa, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + M M + + M + + + + + + + + +|
Dilatation | |
Hyperplasia | 2 |
Inflammation, Acute | 3 1 |
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia | 1 1 1 |
Inflammation, Acute | 2 2 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia, Reticulum Cell | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Giant Cell, Multiple | 2 |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + M M + + M M +|
Cyst | 2 2|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 1 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +|
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 |
Hyperplasia, Nodular | |
Pigmentation | 2 1 |
__________________________________________________________________________|
Thymus | + + + M + + + M M + M + + + + M + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + M + + + + + + M + + M|
Dilatation | 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternum, Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 1| 4| 2| 2| 2| 2| 7| 2| 2| 2| 4| 8| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|
| 9| 9| 9| 1| 9| 9| 9| 9| 9| 5| 9| 9| 9| 6| 1| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis, Multifocal | |
__________________________________________________________________________|
Spinal Cord | |
Nerve, Demyelination | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Fibrosis, Focal | 1 |
Hyperplasia, Adenomatous | 2 2 1 2 |
Infiltration Cellular, Histiocyte | 1 1 1 2 1 1 |
Metaplasia, Osseous | |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + A + +|
Inflammation, Chronic Active | 3 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Sinus, Foreign Body | |
Sinus, Fungus | 3 |
Sinus, Inflammation, Acute | 2 2 2 |
Turbinate, Foreign Body | 2 |
Turbinate, Inflammation, Acute | 2 |
Turbinate, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Lens Capsule, Cataract | 3 2 2 |
Retina, Atrophy | 3 3 3 2 |
Sclera, Metaplasia, Osseous | 2 1 2 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 1 |
Cyst | 2 |
Hydronephrosis | |
Inflammation, Chronic | |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 1| 4| 2| 2| 2| 2| 7| 2| 2| 2| 4| 8| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|
| 9| 9| 9| 1| 9| 9| 9| 9| 9| 5| 9| 9| 9| 6| 1| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 3 2 2 1 1 2 2 1 2 1 1 2 1 1 1 1 3 2 2 2 2 1|
Papilla, Necrosis | |
Pelvis, Dilatation | |
Pelvis, Inflammation, Acute | |
Renal Tubule, Pigmentation | 2 |
__________________________________________________________________________|
Ureter | |
Inflammation, Acute | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 9| 8| 4| 2| 2| 3| 3| 9| 2| 1| 0| 6| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9|
| 9| 9| 1| 1| 2| 9| 9| 2| 2| 0| 9| 5| 8| 4| 2| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M + + + + A + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + A + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + M + + + + A + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + A + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + + + + A + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X |
Basophilic Focus, Multiple | X X 1 X X X X X X |
Cytologic Alterations | |
Cytologic Alterations, Multiple | X X X X |
Fibrosis, Focal | 1 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | 2 |
Hyperplasia, Nodular | 2 |
Inflammation, Chronic | 2 1 |
Necrosis, Focal | 1 |
Necrosis, Multifocal | 2 |
Vacuolization Cytoplasmic | 2 2 2|
Bile Duct, Cyst | 3 |
Bile Duct, Hyperplasia | 2 2 2 2 1 2 2 1 1 1 2 2 1 2 2 2 2 1 2|
Centrilobular, Necrosis | 3 |
Centrilobular, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic | 2 2 |
Fat, Necrosis | 2 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + M + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Acinus, Atrophy, Diffuse | 3 |
Acinus, Atrophy, Focal | 2 1 1 2 2 1 1 1 1 1 |
Acinus, Hyperplasia, Focal | |
Artery, Inflammation, Chronic | 3 |
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 9| 8| 4| 2| 2| 3| 3| 9| 2| 1| 0| 6| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9|
| 9| 9| 1| 1| 2| 9| 9| 2| 2| 0| 9| 5| 8| 4| 2| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hemorrhage | |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 4 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 2 2 2 2 2 1 1 2 2 2 1 2 1 2 1 2 |
Atrium, Thrombosis | 4 |
Epicardium, Inflammation, Chronic | |
Active | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 2 1 3 2 |
Hypertrophy, Focal | 2 |
Necrosis, Focal | 2|
Vacuolization Cytoplasmic, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M M + M + + + M + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 1 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Inflammation, Chronic | 1 |
C-Cell, Hyperplasia | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 9| 8| 4| 2| 2| 3| 3| 9| 2| 1| 0| 6| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9|
| 9| 9| 1| 1| 2| 9| 9| 2| 2| 0| 9| 5| 8| 4| 2| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Serosa, Hyperplasia, Focal | |
__________________________________________________________________________|
Preputial Gland | + + + + + + M + + + + M + + M + + + + + + M + + +|
Dilatation | 3 |
Hyperplasia | |
Inflammation, Acute | 2 2 1|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 3 |
Inflammation, Acute | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Giant Cell, Multiple | |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M M M + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 2 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Hyperplasia, Nodular | 2 |
Pigmentation | 2 1 |
__________________________________________________________________________|
Thymus | + + M + + M M + + + + + + + + + M + M M + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + + + M + + + + + + + + + + + + M + M + + +|
Dilatation | 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternum, Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 9| 8| 4| 2| 2| 3| 3| 9| 2| 1| 0| 6| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9|
| 9| 9| 1| 1| 2| 9| 9| 2| 2| 0| 9| 5| 8| 4| 2| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis, Multifocal | 2 |
__________________________________________________________________________|
Spinal Cord | + + + |
Nerve, Demyelination | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis, Focal | |
Hyperplasia, Adenomatous | 2 2 1 1 |
Infiltration Cellular, Histiocyte | 1 2 1 1 1|
Metaplasia, Osseous | 1 2 |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 2 |
Sinus, Foreign Body | 2 |
Sinus, Fungus | |
Sinus, Inflammation, Acute | 2 1 2 |
Turbinate, Foreign Body | |
Turbinate, Inflammation, Acute | |
Turbinate, Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Lens Capsule, Cataract | 2 |
Retina, Atrophy | 2 2 2 3 |
Sclera, Metaplasia, Osseous | 1 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic, Focal | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | 3 2 |
Hydronephrosis | 3 |
Inflammation, Chronic | 2 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 6| 6| 5| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 2| 9| 8| 4| 2| 2| 3| 3| 9| 2| 1| 0| 6| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9|
| 9| 9| 1| 1| 2| 9| 9| 2| 2| 0| 9| 5| 8| 4| 2| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 2 2 1 1 1 2 1 1 2 2 2 2 1 2 3 1 2 1 1 2 2|
Papilla, Necrosis | 2 |
Pelvis, Dilatation | 4 |
Pelvis, Inflammation, Acute | 1 |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Ureter | + |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 4 |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 6| 1| 7| | |
DAY ON TEST | 2| 2| 9| 9| 0| 2| 1| 6| 4| 2| | |
| 9| 9| 6| 1| 3| 9| 6| 1| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Fibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + A + A + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + A + M + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + A + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + A + M + | 51 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + A + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + A + A + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + A + M + | 53 |
Foreign Body | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + A + M + | 52 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 2 | 3 1.3|
Basophilic Focus | | 4 |
Basophilic Focus, Multiple | X | 15 1.0|
Cytologic Alterations | X | 2 |
Cytologic Alterations, Multiple | | 5 |
Fibrosis, Focal | 2 | 5 1.4|
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 6 |
Hyperplasia, Focal | | 2 2.0|
Hyperplasia, Nodular | | 1 2.0|
Inflammation, Chronic | | 6 1.3|
Necrosis, Focal | | 1 1.0|
Necrosis, Multifocal | | 1 2.0|
Vacuolization Cytoplasmic | 2 | 6 1.8|
Bile Duct, Cyst | | 1 3.0|
Bile Duct, Hyperplasia | 1 1 2 1 | 42 1.6|
Centrilobular, Necrosis | | 1 3.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | 1 | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 13 |
Inflammation, Chronic | | 2 2.0|
Fat, Necrosis | 1 2 | 12 2.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 1 1.0|
Acinus, Atrophy, Diffuse | | 1 3.0|
Acinus, Atrophy, Focal | 1 2 1 | 22 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 6| 1| 7| | |
DAY ON TEST | 2| 2| 9| 9| 0| 2| 1| 6| 4| 2| | |
| 9| 9| 6| 1| 3| 9| 6| 1| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinus, Hyperplasia, Focal | 1 | 1 1.0|
Artery, Inflammation, Chronic | | 1 3.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 58 |
Cyst | 2 | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic | | 2 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Inflammation, Chronic | 2 | 2 2.0|
Inflammation, Chronic Active | | 1 4.0|
Ulcer | 1 3 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Edema | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 2 1 1 2 | 47 1.7|
Atrium, Thrombosis | | 3 3.7|
Epicardium, Inflammation, Chronic | | |
Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Hyperplasia | | 6 2.0|
Hypertrophy, Focal | | 1 2.0|
Necrosis, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + M + | 58 |
Hyperplasia | 2 1 | 21 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + | 51 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 57 |
Hemorrhage | 2 | 1 2.0|
Pars Distalis, Angiectasis | | 2 1.5|
Pars Distalis, Hyperplasia | | 8 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 6| 1| 7| | |
DAY ON TEST | 2| 2| 9| 9| 0| 2| 1| 6| 4| 2| | |
| 9| 9| 6| 1| 3| 9| 6| 1| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Cyst | | 2 2.0|
Inflammation, Chronic | | 2 1.0|
C-Cell, Hyperplasia | 1 1 | 11 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Serosa, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + M + + + M M M + | 48 |
Dilatation | | 1 3.0|
Hyperplasia | | 1 2.0|
Inflammation, Acute | | 5 1.8|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Hyperplasia | 2 | 7 1.6|
Inflammation, Acute | | 3 2.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + M + | 59 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Fibrosis | | 1 2.0|
Hyperplasia, Reticulum Cell | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Giant Cell, Multiple | | 1 2.0|
Mediastinal, Hemorrhage | 4 | 3 2.7|
Mediastinal, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M M | 50 |
Cyst | | 5 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 4 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + | 57 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Fibrosis, Focal | | 2 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 6| 1| 7| | |
DAY ON TEST | 2| 2| 9| 9| 0| 2| 1| 6| 4| 2| | |
| 9| 9| 6| 1| 3| 9| 6| 1| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | | 1 2.0|
Hyperplasia, Nodular | | 1 2.0|
Pigmentation | | 4 1.5|
__________________________________________________________________________|____________|
Thymus | + + + + + M M + + + | 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + M M | 48 |
Dilatation | | 5 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Sternum, Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Thrombosis, Multifocal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 3 |
Nerve, Demyelination | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 2 4 2 | 5 2.8|
Fibrosis, Focal | | 1 1.0|
Hyperplasia, Adenomatous | 1 2 | 10 1.6|
Infiltration Cellular, Histiocyte | 2 | 12 1.3|
Metaplasia, Osseous | | 2 1.5|
Pigmentation | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + M + | 58 |
Inflammation, Chronic Active | | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 2 2.0|
Sinus, Foreign Body | | 1 2.0|
Sinus, Fungus | | 1 3.0|
Sinus, Inflammation, Acute | 2 | 7 1.9|
Turbinate, Foreign Body | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 6| 1| 7| | |
DAY ON TEST | 2| 2| 9| 9| 0| 2| 1| 6| 4| 2| | |
| 9| 9| 6| 1| 3| 9| 6| 1| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Turbinate, Inflammation, Acute | | 1 2.0|
Turbinate, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 8 |
Lens Capsule, Cataract | | 4 2.3|
Retina, Atrophy | | 8 2.5|
Sclera, Metaplasia, Osseous | | 4 1.5|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Inflammation, Chronic, Focal | | 2 1.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Abscess | | 1 1.0|
Cyst | 2 | 4 2.3|
Hydronephrosis | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Mineralization | | 1 1.0|
Nephropathy | 2 1 1 2 2 3 4 1 1 | 52 1.7|
Papilla, Necrosis | | 1 2.0|
Pelvis, Dilatation | | 1 4.0|
Pelvis, Inflammation, Acute | | 1 1.0|
Renal Tubule, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Ureter | | 1 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Hemorrhage | | 2 4.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 3| 7| 6| 6| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 9| 3| 2| 6| 0| 7| 4| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 8| 7| 3| 3| 1| 3| 0|
| 0| 0| 4| 0| 5| 5| 7| 1| 1| 9| 0| 0| 0| 0| 0| 0| 0| 3| 3| 5| 0| 0| 6| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + +|
Necrosis | 2|
__________________________________________________________________________|
Intestine Large | + A + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A M + + + + A + + + + + M|
Inflammation, Acute | |
Parasite Protozoan | |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + A + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + A + + + + + M|
__________________________________________________________________________|
Intestine Small | + A + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + A + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + A + + + + + M|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + A + + + + + M|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X |
Basophilic Focus, Multiple | X X |
Congestion | 2 |
Cytologic Alterations | X |
Fibrosis, Focal | 2 |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | 2 |
Hyperplasia, Nodular | 2 |
Inflammation, Chronic | |
Necrosis, Focal | 2 |
Vacuolization Cytoplasmic | 4 2 1 1 |
Bile Duct, Hyperplasia | 3 1 1 1 2 2 2 2 2 2 3 1 2 1 1 |
Centrilobular, Congestion | 2 |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A|
Cyst | 1 2 |
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + +|
Edema | 3 |
Fungus | X |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + +|
Atrophy | |
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 3| 7| 6| 6| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 9| 3| 2| 6| 0| 7| 4| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 8| 7| 3| 3| 1| 3| 0|
| 0| 0| 4| 0| 5| 5| 7| 1| 1| 9| 0| 0| 0| 0| 0| 0| 0| 3| 3| 5| 0| 0| 6| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | 3 |
Erosion | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 3 2 1 2 1 1 2 |
Atrium, Thrombosis | |
Epicardium, Fibrosis | |
Epicardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
Hypertrophy, Focal | 2 |
Necrosis, Focal | 2 |
Vacuolization Cytoplasmic, Focal | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 1 1 2 |
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 1 2 1 |
Pars Distalis, Inflammation, Chronic | |
Pars Distalis, Thrombosis | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
C-Cell, Hyperplasia | 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | + + + + + M + + + + M + M M + M|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 3| 7| 6| 6| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 9| 3| 2| 6| 0| 7| 4| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 8| 7| 3| 3| 1| 3| 0|
| 0| 0| 4| 0| 5| 5| 7| 1| 1| 9| 0| 0| 0| 0| 0| 0| 0| 3| 3| 5| 0| 0| 6| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Pigmentation | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + +|
Cyst | |
Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + A|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Focal | 2 2 1 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + M + + + + +|
Dilatation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + M + + +|
Cyst Epithelial Inclusion | |
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + +|
Congestion | 2 |
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 3 3 2 3|
Fibrosis, Focal | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 3| 7| 6| 6| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 9| 3| 2| 6| 0| 7| 4| 9| 7| 3| 3| 3| 3| 3| 3| 3| 0| 8| 7| 3| 3| 1| 3| 0|
| 0| 0| 4| 0| 5| 5| 7| 1| 1| 9| 0| 0| 0| 0| 0| 0| 0| 3| 3| 5| 0| 0| 6| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | 2 2 |
Hemorrhage | |
Hyperplasia | |
Hyperplasia, Adenomatous | 2 2 |
Infiltration Cellular, Histiocyte | 2 1 1 2 1 1 1 1 |
Leukocytosis | 4 |
Necrosis, Multifocal | 2 |
Thrombosis | 2 2 |
Interstitium, Edema | |
Interstitium, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + M|
Nasolacrimal Duct, Inflammation, | |
Acute | |
Sinus, Foreign Body | |
Sinus, Fungus | 2 2 2 3 |
Sinus, Hemorrhage | 3 |
Sinus, Inflammation, Acute | 2 2 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + +|
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Hemorrhage | 3 |
Capsule, Lens, Cataract | |
Lens Capsule, Cataract | 3 3 |
Retina, Atrophy | 2 2 3 3 |
Sclera, Metaplasia, Osseous | 2 2 2 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hydronephrosis | |
Inflammation, Suppurative | 2 |
Nephropathy | 1 2 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 |
Renal Tubule, Atrophy, Diffuse | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 1| 7| 2| 3| 3| 4| 6| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9|
| 0| 6| 6| 0| 0| 0| 1| 8| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + +|
Inflammation, Acute | |
Parasite Protozoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Basophilic Focus | X X X |
Basophilic Focus, Multiple | X X X |
Congestion | 2 1 2 |
Cytologic Alterations | X X X |
Fibrosis, Focal | 1 1 1 |
Hepatodiaphragmatic Nodule | X X X X X X |
Hyperplasia, Focal | 2 2 |
Hyperplasia, Nodular | |
Inflammation, Chronic | 1 |
Necrosis, Focal | |
Vacuolization Cytoplasmic | 2 2 2 |
Bile Duct, Hyperplasia | 2 1 2 2 2 2 2 2 1 |
Centrilobular, Congestion | |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Necrosis | 2 2 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + +|
Cyst | |
Acinus, Atrophy, Diffuse | 3 |
Acinus, Atrophy, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + +|
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + +|
Edema | |
Fungus | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + +|
Atrophy | 2 |
Dilatation | 2 |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 1| 7| 2| 3| 3| 4| 6| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9|
| 0| 6| 6| 0| 0| 0| 1| 8| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | |
Erosion | 2 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + +|
Cardiomyopathy | 2 2 1 1 1 2 2 1|
Atrium, Thrombosis | 2 |
Epicardium, Fibrosis | |
Epicardium, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hypertrophy, Focal | |
Necrosis, Focal | |
Vacuolization Cytoplasmic, Focal | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 |
Necrosis | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 2 2 1 1 1 |
Pars Distalis, Inflammation, Chronic | 2 |
Pars Distalis, Thrombosis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
C-Cell, Hyperplasia | 1 1 1 1 |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + M + + M|
__________________________________________________________________________|
Prostate | + + + + + + + + + + +|
Hyperplasia | 1 2 |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 1| 7| 2| 3| 3| 4| 6| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9|
| 0| 6| 6| 0| 0| 0| 1| 8| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Pigmentation | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + +|
Mediastinal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + +|
Cyst | 2 |
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 2 |
Pigmentation | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M M + + + M + +|
Dilatation | 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + +|
Cyst Epithelial Inclusion | 2 |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 2 |
Fibrosis, Focal | 1 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 1| 7| 2| 3| 3| 4| 6| 5| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9|
| 0| 6| 6| 0| 0| 0| 1| 8| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | |
Hemorrhage | 4 |
Hyperplasia | 2 |
Hyperplasia, Adenomatous | 2 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 |
Leukocytosis | |
Necrosis, Multifocal | |
Thrombosis | 2 |
Interstitium, Edema | 2 |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Sinus, Foreign Body | 2 |
Sinus, Fungus | 2 |
Sinus, Hemorrhage | |
Sinus, Inflammation, Acute | 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + +|
Necrosis | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Hemorrhage | |
Capsule, Lens, Cataract | 3 |
Lens Capsule, Cataract | 3 2 |
Retina, Atrophy | 3 3 3 2 |
Sclera, Metaplasia, Osseous | 2 |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2|
Hydronephrosis | 4 |
Inflammation, Suppurative | |
Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 3 1|
Renal Tubule, Atrophy, Diffuse | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 9| 5| 3| 3| 3| 3| 3| 1| | |
| 3| 0| 8| 1| 0| 1| 1| 1| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 28 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 27 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 24 |
Inflammation, Acute | 2 | 1 2.0|
Parasite Protozoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 25 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 25 |
__________________________________________________________________________|____________|
Intestine Small | + + + A | 25 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A | 24 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A | 24 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + A | 23 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 47 |
Angiectasis | | 3 1.3|
Basophilic Focus | X | 7 |
Basophilic Focus, Multiple | | 5 |
Congestion | | 4 1.8|
Cytologic Alterations | | 4 |
Fibrosis, Focal | | 4 1.3|
Hepatodiaphragmatic Nodule | | 9 |
Hyperplasia, Focal | 2 | 4 2.0|
Hyperplasia, Nodular | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Necrosis, Focal | | 1 2.0|
Vacuolization Cytoplasmic | | 7 2.0|
Bile Duct, Hyperplasia | 1 2 2 2 | 28 1.8|
Centrilobular, Congestion | | 1 2.0|
Centrilobular, Necrosis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Mesentery | + + + | 14 |
Fat, Necrosis | 2 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + | 26 |
Cyst | | 2 1.5|
Acinus, Atrophy, Diffuse | | 1 3.0|
Acinus, Atrophy, Focal | | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 27 |
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + | 31 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 29 |
Edema | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 9| 5| 3| 3| 3| 3| 3| 1| | |
| 3| 0| 8| 1| 0| 1| 1| 1| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fungus | | 1 |
Ulcer | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 31 |
Atrophy | | 1 2.0|
Dilatation | | 1 2.0|
Edema | | 1 3.0|
Erosion | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 29 |
Cardiomyopathy | 2 1 1 | 22 1.5|
Atrium, Thrombosis | | 1 2.0|
Epicardium, Fibrosis | 2 | 1 2.0|
Epicardium, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Hyperplasia | | 3 2.0|
Hypertrophy, Focal | | 1 2.0|
Necrosis, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 1 | 8 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 58 |
Hyperplasia | 2 2 | 9 1.4|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 27 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + | 26 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Angiectasis | | 3 2.0|
Pars Distalis, Cyst | | 2 2.0|
Pars Distalis, Hyperplasia | 2 2 1 | 11 1.5|
Pars Distalis, Inflammation, Chronic | | 1 2.0|
Pars Distalis, Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Fibrosis | | 1 2.0|
C-Cell, Hyperplasia | 1 | 6 1.0|
Follicular Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 9| 5| 3| 3| 3| 3| 3| 1| | |
| 3| 0| 8| 1| 0| 1| 1| 1| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + | 29 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + M + | 23 |
__________________________________________________________________________|____________|
Prostate | + + + + | 29 |
Hyperplasia | | 3 1.3|
Inflammation, Acute | | 1 3.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 30 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 58 |
Atrophy | 2 | 3 2.3|
Interstitial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 28 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 29 |
Mediastinal, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 28 |
Cyst | 2 | 2 2.0|
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 28 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 39 |
Congestion | | 1 2.0|
Fibrosis, Focal | 1 | 5 1.6|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | | 1 2.0|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + | 28 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 25 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + | 29 |
Cyst Epithelial Inclusion | | 1 2.0|
Epithelium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 28 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 9| 5| 3| 3| 3| 3| 3| 1| | |
| 3| 0| 8| 1| 0| 1| 1| 1| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 27 |
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + | 27 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 3 2 | 10 2.3|
Fibrosis, Focal | 1 | 2 1.0|
Foreign Body | 1 | 3 1.7|
Hemorrhage | 2 | 2 3.0|
Hyperplasia | | 1 2.0|
Hyperplasia, Adenomatous | | 4 1.8|
Infiltration Cellular, Histiocyte | 1 | 18 1.1|
Leukocytosis | | 1 4.0|
Necrosis, Multifocal | | 1 2.0|
Thrombosis | | 3 2.0|
Interstitium, Edema | | 1 2.0|
Interstitium, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
Sinus, Foreign Body | 2 | 2 2.0|
Sinus, Fungus | 2 2 | 7 2.1|
Sinus, Hemorrhage | | 1 3.0|
Sinus, Inflammation, Acute | 2 2 1 | 11 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + | 28 |
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 8 |
Hemorrhage | | 1 3.0|
Capsule, Lens, Cataract | | 1 3.0|
Lens Capsule, Cataract | | 4 2.8|
Retina, Atrophy | | 8 2.6|
Sclera, Metaplasia, Osseous | | 4 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 2| 3| 9| 5| 3| 3| 3| 3| 3| 1| | |
| 3| 0| 8| 1| 0| 1| 1| 1| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 2 2.5|
Hydronephrosis | | 1 4.0|
Inflammation, Suppurative | | 1 2.0|
Nephropathy | 2 2 1 1 2 1 | 40 1.3|
Renal Tubule, Atrophy, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 27 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 1| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 5| 3| 7| 3| 3| 1| 7| 3| 3| 3| 3| 0| 1| 3| 3| 7| 0| 0| 3| 3| 3| 9| 9|
| 1| 1| 4| 1| 6| 1| 1| 3| 0| 1| 1| 1| 1| 3| 1| 1| 1| 0| 4| 5| 1| 1| 1| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Muscularis, Regeneration | 2 |
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + A + + + + + + +|
Circumanal Gland, Hyperplasia | 2 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + A + + + + + + +|
Parasite Protozoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + A + + + + + + M|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + M A + + + + + + M|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X |
Basophilic Focus, Multiple | X X X X X X X |
Congestion | 2 1 |
Cytologic Alterations | |
Cytologic Alterations, Multiple | X |
Fibrosis, Focal | 1 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | 1 1 |
Vacuolization Cytoplasmic | 2 1 1 3|
Bile Duct, Hyperplasia | 2 2 1 2 2 2 1 2 1 2 2 2 2 2 2 1 1 1 2 1 2 |
Centrilobular, Necrosis | 2 |
Centrilobular, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Artery, Inflammation, Multifocal | |
Fat, Necrosis | 3 3 2 3 2 |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 1 2 2 2 1 1 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Pharynx | + |
Developmental Malformation | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 1 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 1| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 5| 3| 7| 3| 3| 1| 7| 3| 3| 3| 3| 0| 1| 3| 3| 7| 0| 0| 3| 3| 3| 9| 9|
| 1| 1| 4| 1| 6| 1| 1| 3| 0| 1| 1| 1| 1| 3| 1| 1| 1| 0| 4| 5| 1| 1| 1| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 2 1 2 2 2 1 2 1 2 2 2 2 1 1 2 2 1 3 1|
Atrium, Thrombosis | 3 3 |
Endocardium, Fibrosis | |
Epicardium, Inflammation, Chronic | 2 |
Myocardium, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + A + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 |
Necrosis, Focal | |
Vacuolization Cytoplasmic, Focal | 1 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia | 2 1 1 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 1 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 1 2 1 2 2 1 |
Pars Distalis, Vacuolization | |
Cytoplasmic | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
C-Cell, Hyperplasia | 1 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + M + + + + M + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 1| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 5| 3| 7| 3| 3| 1| 7| 3| 3| 3| 3| 0| 1| 3| 3| 7| 0| 0| 3| 3| 3| 9| 9|
| 1| 1| 4| 1| 6| 1| 1| 3| 0| 1| 1| 1| 1| 3| 1| 1| 1| 0| 4| 5| 1| 1| 1| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | |
Inflammation, Acute | |
Inflammation, Chronic | 1 |
Metaplasia, Osseous | |
__________________________________________________________________________|
Prostate | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia | |
Inflammation, Acute | |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Interstitial Cell, Hyperplasia | 1 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + M M + + + M + M + + + + +|
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + M M M + + M M + + +|
Congestion | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + M M + + M M + + + + + + M +|
Dilatation | |
Pigmentation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 3 2 |
Subcutaneous Tissue, Edema | 2 |
Subcutaneous Tissue, Inflammation, | |
Acute | |
Subcutaneous Tissue, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 1| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 5| 3| 7| 3| 3| 1| 7| 3| 3| 3| 3| 0| 1| 3| 3| 7| 0| 0| 3| 3| 3| 9| 9|
| 1| 1| 4| 1| 6| 1| 1| 3| 0| 1| 1| 1| 1| 3| 1| 1| 1| 0| 4| 5| 1| 1| 1| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Cyst | 3 |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Inflammation, Chronic | |
Meninges, Hemorrhage | |
Meninges, Inflammation, Chronic | |
Thalamus, Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 2 2 3 |
Foreign Body | 2 2 2 |
Hemorrhage | |
Hyperplasia, Adenomatous | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Inflammation, Granulomatous | 2 |
Necrosis, Focal | 2 |
Necrosis, Multifocal | 1 2 |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Fibrosis, Focal | |
Interstitium, Inflammation, Chronic | 1 |
Mediastinum, Hemorrhage | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Acute | |
Olfactory Epithelium, Inflammation, | |
Chronic | 2 |
Sinus, Foreign Body | 2 |
Sinus, Fungus | 2 2 |
Sinus, Inflammation, Acute | 2 2 2 2 |
Turbinate, Inflammation, Acute | |
Turbinate, Inflammation, Chronic | 1 2 |
Turbinate, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 1| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 5| 3| 7| 3| 3| 1| 7| 3| 3| 3| 3| 0| 1| 3| 3| 7| 0| 0| 3| 3| 3| 9| 9|
| 1| 1| 4| 1| 6| 1| 1| 3| 0| 1| 1| 1| 1| 3| 1| 1| 1| 0| 4| 5| 1| 1| 1| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + +|
Lens Capsule, Cataract | 2 |
Retina, Atrophy | 3 2 |
Sclera, Metaplasia, Osseous | |
__________________________________________________________________________|
Harderian Gland | + +|
Inflammation, Chronic, Focal | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +|
Congestion | 2 |
Cyst | 1 |
Mineralization | |
Nephropathy | 1 1 1 2 1 1 1 1 1 1 2 1 |
Pelvis, Mineralization | 1|
Renal Tubule, Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 0| 7| 7| 6| 6| 5| 7| 7| 7| 6| 1| 7| 6| 5| 7| 0| 7| 7| 7| 0| 7|
DAY ON TEST | 3| 3| 3| 2| 9| 3| 1| 6| 0| 1| 3| 3| 3| 7| 8| 3| 3| 3| 3| 6| 2| 3| 3| 8| 3|
| 1| 1| 1| 5| 6| 1| 9| 2| 3| 5| 1| 1| 1| 9| 5| 1| 9| 3| 1| 8| 3| 1| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Muscularis, Regeneration | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + A + + + + + M + + + M +|
Circumanal Gland, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M + + + + + + + + A + + + + + M + + + M +|
Parasite Protozoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A A + + + + A + + + + + M + + + M +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + A A + + + + A + + + + + M + + + M +|
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + + + A + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A A + + + + A + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + A A + + + + A + + + + + M + + + M +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + + A A + + + + A + + + + + M + + + M +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | |
Basophilic Focus, Multiple | X X X X X X X|
Congestion | 2 |
Cytologic Alterations | |
Cytologic Alterations, Multiple | |
Fibrosis, Focal | 2 2 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic | 1 |
Vacuolization Cytoplasmic | |
Bile Duct, Hyperplasia | 1 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1|
Centrilobular, Necrosis | 2 3 |
Centrilobular, Vacuolization | |
Cytoplasmic | 2 1 |
__________________________________________________________________________|
Mesentery | + + + |
Artery, Inflammation, Multifocal | |
Fat, Necrosis | 2 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 2 1 2 1 1 2|
Artery, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Pharynx | |
Developmental Malformation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Inflammation, Chronic | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 0| 7| 7| 6| 6| 5| 7| 7| 7| 6| 1| 7| 6| 5| 7| 0| 7| 7| 7| 0| 7|
DAY ON TEST | 3| 3| 3| 2| 9| 3| 1| 6| 0| 1| 3| 3| 3| 7| 8| 3| 3| 3| 3| 6| 2| 3| 3| 8| 3|
| 1| 1| 1| 5| 6| 1| 9| 2| 3| 5| 1| 1| 1| 9| 5| 1| 9| 3| 1| 8| 3| 1| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Acute | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + A + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 2 1 1 2 1 1 1 2 1 |
Atrium, Thrombosis | |
Endocardium, Fibrosis | 2 |
Epicardium, Inflammation, Chronic | 2 |
Myocardium, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 2 2 |
Necrosis, Focal | 2 |
Vacuolization Cytoplasmic, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 1 1 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + M + M + + M + + M M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 2 1 2 |
Pars Distalis, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + A + + + + + A + + + + + + + + + + +|
Cyst | 2 |
C-Cell, Hyperplasia | 1 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + M + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + A + + + + + M + + + + + M + M + M +|
Dilatation | 2 |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 0| 7| 7| 6| 6| 5| 7| 7| 7| 6| 1| 7| 6| 5| 7| 0| 7| 7| 7| 0| 7|
DAY ON TEST | 3| 3| 3| 2| 9| 3| 1| 6| 0| 1| 3| 3| 3| 7| 8| 3| 3| 3| 3| 6| 2| 3| 3| 8| 3|
| 1| 1| 1| 5| 6| 1| 9| 2| 3| 5| 1| 1| 1| 9| 5| 1| 9| 3| 1| 8| 3| 1| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 3 |
Inflammation, Acute | 2 3|
Inflammation, Chronic | |
Metaplasia, Osseous | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + M + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + M + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis, Focal | 2 3 |
Hematopoietic Cell Proliferation | 2 |
Necrosis | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + M + A + + M + + + + M + + +|
Congestion | |
Hemorrhage | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M M + + M M + M + M + M + + M M + + + + M|
Dilatation | |
Pigmentation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + M + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Inflammation, | |
Acute | 2|
Subcutaneous Tissue, Thrombosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 0| 7| 7| 6| 6| 5| 7| 7| 7| 6| 1| 7| 6| 5| 7| 0| 7| 7| 7| 0| 7|
DAY ON TEST | 3| 3| 3| 2| 9| 3| 1| 6| 0| 1| 3| 3| 3| 7| 8| 3| 3| 3| 3| 6| 2| 3| 3| 8| 3|
| 1| 1| 1| 5| 6| 1| 9| 2| 3| 5| 1| 1| 1| 9| 5| 1| 9| 3| 1| 8| 3| 1| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Cyst | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Inflammation, Chronic | |
Meninges, Hemorrhage | 1 |
Meninges, Inflammation, Chronic | |
Thalamus, Compression | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + A + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 4 2 3 4 |
Foreign Body | 2 2 2 |
Hemorrhage | 2 |
Hyperplasia, Adenomatous | |
Infiltration Cellular, Histiocyte | 1 2 1 1 1 |
Inflammation, Granulomatous | |
Necrosis, Focal | |
Necrosis, Multifocal | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Fibrosis, Focal | |
Interstitium, Inflammation, Chronic | 2 |
Mediastinum, Hemorrhage | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Olfactory Epithelium, Inflammation, | |
Chronic | |
Sinus, Foreign Body | |
Sinus, Fungus | 2 2 2 |
Sinus, Inflammation, Acute | 2 2 2 2 2 |
Turbinate, Inflammation, Acute | 2 |
Turbinate, Inflammation, Chronic | 2 |
Turbinate, Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Chronic | |
Necrosis | 3 3 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 0| 7| 7| 6| 6| 5| 7| 7| 7| 6| 1| 7| 6| 5| 7| 0| 7| 7| 7| 0| 7|
DAY ON TEST | 3| 3| 3| 2| 9| 3| 1| 6| 0| 1| 3| 3| 3| 7| 8| 3| 3| 3| 3| 6| 2| 3| 3| 8| 3|
| 1| 1| 1| 5| 6| 1| 9| 2| 3| 5| 1| 1| 1| 9| 5| 1| 9| 3| 1| 8| 3| 1| 1| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + + |
Lens Capsule, Cataract | |
Retina, Atrophy | 3 1 |
Sclera, Metaplasia, Osseous | 2 2 |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | |
Mineralization | 1 |
Nephropathy | 1 2 1 2 4 1 1 1 1 1 2 2 |
Pelvis, Mineralization | |
Renal Tubule, Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 6| 0| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Inflammation, Acute | | 1 3.0|
Muscularis, Regeneration | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + A | 54 |
Circumanal Gland, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A | 53 |
Parasite Protozoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + A | 54 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A | 51 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 2 |
Basophilic Focus, Multiple | X X X X X | 19 |
Congestion | | 3 1.7|
Cytologic Alterations | X | 1 |
Cytologic Alterations, Multiple | | 1 |
Fibrosis, Focal | 2 | 4 1.8|
Hepatodiaphragmatic Nodule | X | 6 |
Inflammation, Chronic | 1 | 4 1.0|
Vacuolization Cytoplasmic | | 4 1.8|
Bile Duct, Hyperplasia | 1 1 1 1 2 2 2 2 | 46 1.7|
Centrilobular, Necrosis | | 3 2.3|
Centrilobular, Vacuolization | | |
Cytoplasmic | 2 | 3 1.7|
__________________________________________________________________________|____________|
Mesentery | + + + | 12 |
Artery, Inflammation, Multifocal | 2 | 1 2.0|
Fat, Necrosis | 3 2 3 | 11 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Acinus, Atrophy, Focal | 1 2 2 | 17 1.6|
Artery, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Developmental Malformation | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 58 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 6| 0| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + M + + + | 58 |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 1 1.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation, | | |
Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Cardiomyopathy | 2 1 1 2 2 2 2 | 43 1.5|
Atrium, Thrombosis | | 2 3.0|
Endocardium, Fibrosis | | 1 2.0|
Epicardium, Inflammation, Chronic | | 2 2.0|
Myocardium, Inflammation, Acute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 59 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | 1 | 4 1.8|
Necrosis, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + M + + | 58 |
Hyperplasia | 1 2 | 14 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M | 51 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | | 5 1.6|
Pars Distalis, Cyst | | 2 2.0|
Pars Distalis, Hyperplasia | 1 2 | 11 1.5|
Pars Distalis, Vacuolization | | |
Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 58 |
Cyst | | 2 1.5|
C-Cell, Hyperplasia | | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 6| 0| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + M M + + | 51 |
Dilatation | | 1 2.0|
Hyperplasia | | 1 3.0|
Inflammation, Acute | 2 | 3 2.3|
Inflammation, Chronic | | 1 1.0|
Metaplasia, Osseous | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + A | 58 |
Hemorrhage | | 1 2.0|
Hyperplasia | | 1 2.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + A | 57 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Atrophy | | 2 2.5|
Interstitial Cell, Hyperplasia | | 4 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M M + | 51 |
Hemorrhage | | 3 2.0|
Hyperplasia, Lymphoid | 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Fibrosis, Focal | 3 | 3 2.7|
Hematopoietic Cell Proliferation | | 2 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 6| 0| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Congestion | 3 | 1 3.0|
Hemorrhage | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + M + + + + | 42 |
Dilatation | 2 | 1 2.0|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Cyst Epithelial Inclusion | | 2 2.5|
Subcutaneous Tissue, Edema | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Acute | | 1 2.0|
Subcutaneous Tissue, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Cyst | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Cerebrum, Inflammation, Chronic | 2 | 1 2.0|
Meninges, Hemorrhage | | 1 1.0|
Meninges, Inflammation, Chronic | 3 | 1 3.0|
Thalamus, Compression | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 59 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 3 | 12 2.7|
Foreign Body | 2 | 7 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Adenomatous | 2 | 2 1.5|
Infiltration Cellular, Histiocyte | 1 2 | 11 1.2|
Inflammation, Granulomatous | | 1 2.0|
Necrosis, Focal | | 1 2.0|
Necrosis, Multifocal | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05041-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SUCCINIC ANHYDRIDE Date: 05/01/97
Route: GAVAGE Time: 11:52:17
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 1| 6| 0| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 3| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | | 1 3.0|
Alveolus, Fibrosis, Focal | 2 | 1 2.0|
Interstitium, Inflammation, Chronic | | 2 1.5|
Mediastinum, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + A | 59 |
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
Olfactory Epithelium, Inflammation, | | |
Chronic | | 1 2.0|
Sinus, Foreign Body | 2 2 | 3 2.0|
Sinus, Fungus | | 5 2.0|
Sinus, Inflammation, Acute | 2 2 | 11 2.0|
Turbinate, Inflammation, Acute | | 1 2.0|
Turbinate, Inflammation, Chronic | | 3 1.7|
Turbinate, Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 1 2.0|
Necrosis | | 3 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 8 |
Lens Capsule, Cataract | 2 | 2 2.0|
Retina, Atrophy | 3 | 5 2.4|
Sclera, Metaplasia, Osseous | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Inflammation, Chronic, Focal | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Congestion | | 1 2.0|
Cyst | | 1 1.0|
Mineralization | 1 | 2 1.0|
Nephropathy | 1 1 | 26 1.3|
Pelvis, Mineralization | | 1 1.0|
Renal Tubule, Pigmentation | | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Hemorrhage | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 795557-795557/795557
--multipart-boundary--