TR 373 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Microbiological Assoc. DATE: 09/05/94
EXP: 05041 SUCCINIC ANHYDRIDE TIME: 13:27:45
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 55696B
CONT: N01ES2802601 CAS: 108-30-5
PATHOLOGIST: W. HALL
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Microbiological Assoc. DATE: 09/05/94
EXP: 05041 SUCCINIC ANHYDRIDE TIME: 13:27:45
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 55696B
CONT: N01ES2802601 CAS: 108-30-5
PATHOLOGIST: W. HALL
SUCCINIC ANHYDRIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 23 CENSORED DEATHS 1 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 364 481 542 549 575 590 599 603 632 632 |
| 642 646 661 681 691 691 696 706 708 711 |
| 715 716 723 |
| CENSORED DEATHS |
| 145 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50MG/KG LOW |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 25 CENSORED DEATHS 2 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 2 279 365 451 495 550 568 575 583 598 |
| 619 620 634 641 641 662 676 677 690 703 |
| 705 714 716 716 723 |
| CENSORED DEATHS |
| 191 620 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100MG/KGHIGH |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 24 CENSORED DEATHS 4 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 68 82 96 185 463 515 533 554 570 603 |
| 604 625 639 662 670 679 695 698 703 711 |
| 711 713 719 723 |
| CENSORED DEATHS |
| 176 209 305 431 |
| |
==================================================================================
SUCCINIC ANHYDRIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.3 98.3 96.6 94.9 86.4 78.0 61.0 |
| | |
| | |
|50MG/KG LOW| 98.3 98.3 98.3 94.9 94.9 93.2 91.6 83.1 72.8 57.2 |
| | |
| | |
|100MG/KGHIG| 96.7 95.0 93.3 93.3 93.3 91.5 87.9 80.7 75.4 57.4 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 50MG/KG LOW 100MG/KGHIGH |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 61.0% 57.2% 57.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.656 P=0.690 P=0.718 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 632.8 584.1 550.9 |
|NATURAL DEATHS (C) | (18.4) (33.0) (44.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 682.4 657.9 627.8 |
|(STANDARD ERROR) | (13.0) (18.2) (24.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
SUCCINIC ANHYDRIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 28 CENSORED DEATHS 1 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 77 169 479 494 507 516 553 576 604 606 |
| 611 616 620 640 641 642 663 670 695 705 |
| 705 707 711 715 719 723 723 726 |
| CENSORED DEATHS |
| 9 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50MG/KG LOW |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 26 CENSORED DEATHS 7 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 2 2 11 169 187 401 471 541 590 599 |
| 603 606 606 617 620 642 677 684 689 691 |
| 695 705 723 723 723 723 |
| CENSORED DEATHS |
| 5 9 9 9 10 12 13 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100MG/KG HIGH |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 24 CENSORED DEATHS 9 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 198 225 337 353 365 417 503 563 586 606 |
| 606 619 625 629 642 663 674 678 705 711 |
| 720 720 726 726 |
| CENSORED DEATHS |
| 5 5 9 9 111 170 176 200 283 |
| |
==================================================================================
SUCCINIC ANHYDRIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 98.3 96.6 96.6 96.6 96.6 94.9 89.8 84.7 71.2 52.5 |
| | |
| | |
|50MG/KG LOW| 94.8 92.9 91.0 91.0 89.2 87.3 85.4 79.7 70.2 51.2 |
| | |
| | |
|100MG/KG | 100.0 100.0 96.2 90.3 88.3 88.3 86.4 82.4 68.7 53.0 |
|HIGH | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 50MG/KG LOW 100MG/KG |
| HIGH |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 52.5% 51.2% 53.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000 P=0.873 P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 600.5 526.9 566.5 |
|NATURAL DEATHS (C) | (29.2) (47.3) (33.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 657.0 557.5 570.8 |
|(STANDARD ERROR) | (19.3) (35.1) (30.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
SUCCINIC ANHYDRIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
50MG/KG LOW = 2
100MG/KGHIGH = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 12 3 1
| 2 3 3 2 1 1
|
| 3 3 2 2 1 1
95 + 3 3 2 2 11
| 3 2 3 2 1 1
|
| 3 2 3 2 1 1
90 + 3 3 2 2 11
| 22 11
P | 3 3
E | 3 322 1 1
R 85 + 2 2
C | 3 3
E | 2 2 11
N | 3 3 11
T 80 + 2 2 1 1
| 3 3
S | 22 1 1
U | 11
R 75 + 2 23
V | 33
I | 2 2 11
V | 3 11
A 70 + 11
L | 2 233
| 2 2
| 311
65 +
| 22
| 211
| 331 1
60 +
| 22
| 2 2
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 12 obs hidden.
SUCCINIC ANHYDRIDE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
50MG/KG LOW = 2
100MG/KG HIGH = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 12 1 3
| 1 1
| 3 3
| 22 1 3 3 1
95 + 2 2 1 1
| 3 3 1 1
| 2 2 3 3
| 2 2 11
90 + 3 3 1 1
| 2 3 2 3 1 1
| 2 2
| 3 3 1 1
P 85 + 2 3 3 2
E | 22
R | 3 11
C | 22
E 80 + 11
N | 3 3
T | 1 1
| 2 23
S 75 +
U |
R | 23 1 1
V | 3 11
I 70 + 2 12 1
V | 3 22
A | 11
L | 22
65 + 3 3
|
| 2211
| 2211
60 +
| 2 2
| 11
|
55 +
|
| 1 1
| 2 2
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 16 obs hidden.
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