TR 380 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
EPINEPHRINE HCL
NTP Experiment-Test: 05095-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:50:54
Facility: Battelle Northwest
Chemical CAS #: 55-31-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05095-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:50:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 1.5MG/M3 3.0MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 11 7 9
Moribund 7 8 7
Survivors
Moribund 1
Terminal Sacrifice 32 35 33
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (47) (15) (48)
Dilatation 1 (7%)
Intestine Large, Colon (49) (15) (50)
Inflammation, Chronic 1 (7%)
Intestine Large, Rectum (50) (15) (50)
Prolapse 1 (7%)
Intestine Small, Ileum (49) (14) (50)
Amyloid Deposition 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Jejunum (49) (18) (50)
Inflammation, Suppurative 1 (6%)
Liver (50) (20) (50)
Cyst 2 (4%)
Cytologic Alterations 1 (5%)
Focal Cellular Change 1 (5%) 2 (4%)
Hemorrhage 1 (2%)
Infarct 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%)
Inflammation, Subacute 2 (4%) 3 (6%)
Necrosis 3 (6%) 1 (2%)
Pancreas (50) (16) (50)
Inflammation, Subacute 1 (2%)
Acinus, Hypoplasia 1 (2%)
Duct, Cyst 1 (2%)
Salivary Glands (49) (14) (49)
Hemorrhage 1 (7%)
Stomach, Forestomach (50) (19) (49)
Hyperkeratosis 6 (12%) 1 (5%) 3 (6%)
Hyperplasia, Lymphoid 1 (5%)
Inflammation, Subacute 1 (2%)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (5%) 1 (2%)
Epithelium, Hyperplasia 1 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05095-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:50:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 1.5MG/M3 3.0MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Glandular (50) (15) (50)
Hyperplasia 3 (6%)
Inflammation, Subacute 1 (2%)
Mineralization 1 (2%) 1 (2%)
Pigmentation 1 (2%)
Tooth (1) (3)
Abscess 1 (100%)
Developmental Malformation 3 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (15) (50)
Atrium, Thrombosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (16) (50)
Hyperplasia 1 (2%)
Hyperplasia, Focal 1 (2%) 1 (2%)
Hypertrophy, Focal 2 (4%) 1 (6%) 1 (2%)
Adrenal Gland, Medulla (50) (16) (50)
Hyperplasia 1 (2%) 1 (6%) 2 (4%)
Pituitary Gland (49) (46) (49)
Congestion 4 (8%) 1 (2%) 1 (2%)
Hyperplasia 18 (37%) 17 (37%) 22 (45%)
Pigmentation 1 (2%)
Pars Distalis, Hyperplasia 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (49) (18) (48)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic 1 (6%)
Follicular Cell, Cyst 1 (6%)
Follicular Cell, Hyperplasia 4 (8%) 6 (13%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05095-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:50:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 1.5MG/M3 3.0MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (26) (50)
Corpora Amylacea 1 (2%)
Cyst 18 (36%) 12 (46%) 11 (22%)
Cyst, Multiple 1 (4%)
Hemorrhage 1 (2%)
Mineralization 2 (8%)
Pigmentation 1 (4%)
Germinal Epithelium, Hyperplasia 1 (4%)
Rete Ovarii, Hyperplasia 1 (2%)
Uterus (50) (19) (50)
Angiectasis 1 (2%)
Dilatation 1 (2%) 1 (5%)
Hyperplasia, Cystic 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Prolapse 1 (2%)
Thrombosis 1 (2%)
Artery, Thrombosis 1 (2%)
Endometrium, Degeneration, Hyaline 1 (2%)
Endometrium, Hyperplasia 8 (16%) 1 (5%) 8 (16%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (15) (50)
Myelofibrosis 2 (4%) 1 (2%)
Lymph Node (50) (29) (49)
Iliac, Hyperplasia, Lymphoid 1 (3%) 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Mesenteric, Congestion 1 (2%) 1 (3%)
Mesenteric, Hyperplasia, Lymphoid 2 (4%)
Renal, Hyperplasia, Lymphoid 2 (4%)
Lymph Node, Bronchial (45) (20) (49)
Hyperplasia, Lymphoid 3 (15%) 1 (2%)
Lymph Node, Mandibular (49) (19) (45)
Atrophy 1 (2%)
Hyperplasia, Lymphoid 3 (16%) 7 (16%)
Pigmentation 1 (2%) 1 (2%)
Spleen (50) (25) (50)
Atrophy 2 (4%)
Hematopoietic Cell Proliferation 4 (8%) 2 (8%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 4 (8%) 3 (12%) 5 (10%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05095-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:50:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 1.5MG/M3 3.0MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (44) (14) (45)
Duct, Dilatation, Multifocal 1 (2%)
Skin (49) (23) (49)
Alopecia 5 (10%) 6 (26%) 6 (12%)
Edema 1 (4%) 2 (4%)
Inflammation, Chronic 1 (4%) 1 (2%)
Inflammation, Necrotizing 1 (4%) 1 (2%)
Ulcer 1 (2%)
Sebaceous Gland, Hyperplasia 1 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (15) (50)
Costochondral Junction, Degeneration 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (15) (50)
Hemorrhage, Acute, Multifocal 1 (7%)
Inflammation, Subacute 1 (2%)
Mineralization 9 (18%) 3 (20%) 16 (32%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (27) (50)
Congestion 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Lymphocyte 2 (4%) 1 (4%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Granulomatous 5 (10%) 2 (7%) 3 (6%)
Inflammation, Subacute 2 (4%) 1 (4%) 1 (2%)
Thrombosis 2 (7%)
Alveolar Epithelium, Hyperplasia 2 (4%) 2 (7%) 1 (2%)
Interstitium, Fibrosis 1 (2%)
Nose (50) (48) (50)
Inflammation, Suppurative 1 (2%) 7 (15%) 8 (16%)
Olfactory Epithelium, Degeneration, Hyaline 44 (88%) 43 (90%) 47 (94%)
Olfactory Epithelium, Metaplasia 1 (2%)
Olfactory Epithelium, Metaplasia, Focal 10 (20%) 21 (44%) 12 (24%)
Respiratory Epithelium, Degeneration 1 (2%)
Respiratory Epithelium, Degeneration, Hyaline 7 (14%) 28 (58%) 19 (38%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Respiratory Epithelium, Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05095-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:50:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 1.5MG/M3 3.0MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (19) (50)
Cyst 1 (2%) 1 (2%)
Hemorrhage, Acute 1 (5%)
Hydronephrosis 1 (2%) 1 (5%)
Inflammation, Subacute 1 (2%) 2 (4%)
Metaplasia, Osseous 1 (2%)
Glomerulus, Amyloid Deposition 1 (2%)
Renal Tubule, Degeneration, Hyaline 1 (5%)
Urinary Bladder (50) (15) (50)
Infiltration Cellular, Lymphocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05095-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:50:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 1.5MG/M3 3.0MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 10 4 4
Moribund 7 12 10
Survivors
Terminal Sacrifice 33 34 36
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (50) (15) (50)
Inflammation, Suppurative 1 (2%)
Intestine Small (50) (18) (50)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Ileum (50) (17) (49)
Amyloid Deposition 1 (2%)
Hyperplasia, Lymphoid 1 (6%)
Intestine Small, Jejunum (50) (17) (50)
Hyperplasia, Lymphoid 1 (6%) 1 (2%)
Liver (50) (25) (50)
Congestion 1 (2%)
Focal Cellular Change 1 (2%) 1 (4%) 1 (2%)
Hemorrhage 1 (2%)
Infarct 1 (2%) 1 (4%) 3 (6%)
Inflammation, Subacute 1 (4%) 1 (2%)
Necrosis 1 (2%) 2 (8%)
Bile Duct, Cyst 1 (2%)
Serosa, Fibrosis, Chronic 1 (4%)
Pancreas (50) (16) (50)
Hemorrhage 1 (2%)
Duct, Cyst 1 (2%)
Stomach, Forestomach (47) (16) (50)
Hyperkeratosis 1 (6%) 2 (4%)
Inflammation, Subacute 1 (2%) 1 (2%)
Ulcer 1 (2%)
Stomach, Glandular (49) (16) (50)
Hyperplasia 2 (4%) 1 (6%) 2 (4%)
Subserosa, Cyst 1 (2%)
Tooth (2) (1)
Inflammation, Suppurative 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05095-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:50:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 1.5MG/M3 3.0MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (16) (50)
Artery, Inflammation, Subacute 1 (2%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (32) (48)
Hyperplasia 1 (3%) 3 (6%)
Hyperplasia, Diffuse 2 (4%)
Hyperplasia, Focal 2 (4%) 4 (13%) 1 (2%)
Hypertrophy 2 (6%) 3 (6%)
Hypertrophy, Diffuse 1 (3%) 3 (6%)
Hypertrophy, Focal 16 (32%) 12 (38%) 13 (27%)
Adrenal Gland, Medulla (48) (16) (45)
Hyperplasia, Focal 1 (2%)
Pituitary Gland (50) (16) (48)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Penis (2)
Abscess 1 (50%)
Inflammation, Chronic 1 (50%)
Preputial Gland (13) (9) (7)
Inflammation, Chronic 1 (8%) 1 (11%)
Inflammation, Suppurative 5 (38%) 4 (44%) 4 (57%)
Duct, Dilatation 6 (46%) 4 (44%) 1 (14%)
Duct, Hyperplasia 1 (8%)
Prostate (48) (13) (49)
Inflammation, Suppurative 2 (4%) 1 (8%) 1 (2%)
Seminal Vesicle (2) (4) (1)
Dilatation 1 (25%)
Inflammation, Chronic 1 (50%)
Inflammation, Suppurative 1 (50%)
Testes (50) (15) (50)
Atrophy 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05095-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:50:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 1.5MG/M3 3.0MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (16) (50)
Hyperplasia, Neutrophil 1 (2%) 1 (6%)
Lymph Node (49) (20) (50)
Mediastinal, Hyperplasia, Lymphoid 1 (5%)
Mesenteric, Hyperplasia, Lymphoid 1 (2%)
Mesenteric, Sinus, Dilatation 1 (5%)
Renal, Hyperplasia, Lymphoid 1 (5%)
Lymph Node, Bronchial (43) (13) (49)
Hyperplasia, Lymphoid 1 (8%) 1 (2%)
Lymph Node, Mandibular (43) (12) (41)
Hyperplasia, Lymphoid 3 (7%) 2 (5%)
Spleen (50) (20) (50)
Atrophy 1 (5%)
Hematopoietic Cell Proliferation 3 (6%) 2 (10%) 1 (2%)
Hyperplasia, Lymphoid 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (48) (21) (49)
Alopecia 3 (6%) 4 (19%) 3 (6%)
Inflammation, Necrotizing 1 (2%)
Inflammation, Suppurative 2 (4%) 1 (5%) 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (16) (50)
Abscess 1 (6%)
Infiltration Cellular, Lymphocyte 1 (2%)
Mineralization 30 (60%) 2 (13%) 31 (62%)
Meninges, Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (32) (50)
Congestion 2 (4%) 2 (4%)
Hemorrhage, Acute 1 (3%)
Hemorrhage, Focal 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05095-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:50:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 1.5MG/M3 3.0MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Infiltration Cellular, Histiocyte 2 (4%) 3 (9%)
Inflammation, Subacute 4 (8%) 1 (3%) 2 (4%)
Inflammation, Suppurative 3 (9%) 1 (2%)
Leukocytosis 1 (2%)
Alveolar Epithelium, Hyperplasia 7 (14%) 6 (19%) 6 (12%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 2 (4%)
Bronchiole, Hyperplasia 2 (4%)
Bronchiole, Hyperplasia, Focal 5 (16%)
Bronchus, Ulcer, Focal 1 (2%)
Pleura, Inflammation, Subacute 1 (2%)
Nose (50) (50) (50)
Hemorrhage, Acute 1 (2%)
Inflammation, Suppurative 1 (2%) 4 (8%) 3 (6%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
Olfactory Epithelium, Degeneration, Focal,
Hyaline 1 (2%)
Olfactory Epithelium, Degeneration, Hyaline 3 (6%) 17 (34%) 39 (78%)
Olfactory Epithelium, Metaplasia, Focal 8 (16%) 11 (22%) 8 (16%)
Respiratory Epithelium, Degeneration, Hyaline 5 (10%) 2 (4%) 2 (4%)
Respiratory Epithelium, Hyperplasia, Focal 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (16) (50)
Atrophy 1 (6%)
Bacterium, Acute 1 (2%)
Developmental Malformation 1 (6%)
Fibrosis, Focal 1 (2%)
Hemorrhage, Focal 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Suppurative 1 (6%) 1 (2%)
Metaplasia, Osseous 1 (2%) 1 (2%)
Mineralization 1 (6%) 1 (2%)
Nephropathy 1 (2%) 1 (2%)
Pelvis, Inflammation, Chronic 2 (4%) 2 (13%) 2 (4%)
Pelvis, Inflammation, Suppurative 1 (6%) 1 (2%)
Renal Tubule, Casts 2 (4%)
Renal Tubule, Degeneration 2 (4%)
Renal Tubule, Dilatation 1 (2%)
Renal Tubule, Regeneration 3 (6%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05095-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/13/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 00:50:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 1.5MG/M3 3.0MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Renal Tubule, Regeneration, Focal 1 (2%) 1 (2%)
Urinary Bladder (50) (16) (50)
Concretion 1 (2%)
Dilatation 1 (2%) 1 (6%)
Hyperplasia 1 (6%)
Inflammation, Subacute 1 (2%) 1 (6%)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
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