TR 380 Mouse Pathology Tables
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
Facility: Battelle Northwest
Chemical CAS #: 55-31-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 6| 5| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 6| 6| 2| 4| 4| 2| 4| 4| 4| 4| 4| 4| 1| 4| 0| 4| 3| 4| 4| 3| 4| 5| 0| 1| 4|
| 7| 6| 8| 2| 2| 0| 2| 2| 2| 2| 2| 2| 4| 2| 3| 2| 2| 2| 2| 1| 2| 8| 7| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + + M + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + M + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + M + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hemorrhage | |
Infarct | 4 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Subacute | 2 |
Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Subacute | 2|
Mineralization | |
Pigmentation | 2 |
__________________________________________________________________________|
Tooth | |
Abscess | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 6| 5| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 6| 6| 2| 4| 4| 2| 4| 4| 4| 4| 4| 4| 1| 4| 0| 4| 3| 4| 4| 3| 4| 5| 0| 1| 4|
| 7| 6| 8| 2| 2| 0| 2| 2| 2| 2| 2| 2| 4| 2| 3| 2| 2| 2| 2| 1| 2| 8| 7| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M + M + M M + M M M M M + M M M M + M + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 4 2 |
Hyperplasia | 4 1 1 2 3 3 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | |
Cyst | 2 3 X X X 2 2 X 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Cystic | |
Endometrium, Degeneration, Hyaline | 2 |
Endometrium, Hyperplasia | 2 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Congestion | 3 |
Mesenteric, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +|
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + M + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + M M + + + + + + M + + + + + + + + M + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | X 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 6| 5| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 6| 6| 2| 4| 4| 2| 4| 4| 4| 4| 4| 4| 1| 4| 0| 4| 3| 4| 4| 3| 4| 5| 0| 1| 4|
| 7| 6| 8| 2| 2| 0| 2| 2| 2| 2| 2| 2| 4| 2| 3| 2| 2| 2| 2| 1| 2| 8| 7| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Mineralization | 2 1 1 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Granulomatous | |
Inflammation, Subacute | 2 2 |
Alveolar Epithelium, Hyperplasia | 3 2 |
Interstitium, Fibrosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 2 2 2 2 2 2 1 2 2 2 2 2 2 1 1 2 2 1 1 2|
Olfactory Epithelium, Metaplasia, | |
Focal | 1 1 1 1 |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 2 2 2 2 2 |
Respiratory Epithelium, Degeneration | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | |
Inflammation, Subacute | 2 |
Metaplasia, Osseous | 1 |
Glomerulus, Amyloid Deposition | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 4| 4| 2| 4| 4| 4| 1| 4| 2| 4| 4| 4| 4| 8| 1| 4| 4| 4| 4| 4| 4| 7| 4| 8| 4| |
| 2| 2| 4| 2| 2| 2| 5| 2| 4| 2| 2| 2| 2| 9| 3| 2| 2| 2| 2| 2| 2| 9| 2| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 2 |
Hemorrhage | 2 | 1 2.0|
Infarct | | 1 4.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Inflammation, Subacute | 4 | 2 3.0|
Necrosis | 2 3 | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 1 2 4 2 3| 6 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 3 | 3 2.3|
Inflammation, Subacute | | 1 2.0|
Mineralization | 1 | 1 1.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Abscess | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 4| 4| 2| 4| 4| 4| 1| 4| 2| 4| 4| 4| 4| 8| 1| 4| 4| 4| 4| 4| 4| 7| 4| 8| 4| |
| 2| 2| 4| 2| 2| 2| 5| 2| 4| 2| 2| 2| 2| 9| 3| 2| 2| 2| 2| 2| 2| 9| 2| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 2.0|
Hypertrophy, Focal | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + M + + + + + + M M + M + + M M M M M M M M| 18 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Congestion | 1 | 4 2.0|
Hyperplasia | 2 3 2 4 2 3 2 1 2 2 4 4| 18 2.5|
Pars Intermedia, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | | 1 3.0|
Follicular Cell, Hyperplasia | 1 2 4 | 4 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corpora Amylacea | 2 | 1 2.0|
Cyst | X 3 2 4 2 2 1 3 2 | 18 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 | 1 4.0|
Hyperplasia, Cystic | 4 | 1 4.0|
Endometrium, Degeneration, Hyaline | | 1 2.0|
Endometrium, Hyperplasia | 1 2 4 2 4 | 8 2.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesenteric, Congestion | | 1 3.0|
Mesenteric, Hyperplasia, Lymphoid | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + + + M M + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 3 4 3| 4 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 4| 4| 2| 4| 4| 4| 1| 4| 2| 4| 4| 4| 4| 8| 1| 4| 4| 4| 4| 4| 4| 7| 4| 8| 4| |
| 2| 2| 4| 2| 2| 2| 5| 2| 4| 2| 2| 2| 2| 9| 3| 2| 2| 2| 2| 2| 2| 9| 2| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Histiocytic | | 1 3.0|
Hyperplasia, Lymphoid | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 44 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Alopecia | 2 2 2 | 5 2.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | | 1 2.0|
Mineralization | 2 2 2 1| 9 1.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 2 2 | 2 2.0|
Inflammation, Granulomatous | 1 1 2 1 4 | 5 1.8|
Inflammation, Subacute | | 2 2.0|
Alveolar Epithelium, Hyperplasia | | 2 2.5|
Interstitium, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 2 1 1 1 1 2 2 2 2 1 2 2 2 2 2 2 2 2 2 3| 44 1.7|
Olfactory Epithelium, Metaplasia, | | |
Focal | 1 1 1 3 2 1| 10 1.3|
Olfactory Epithelium, Metaplasia | 1 | 1 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 | 7 1.7|
Respiratory Epithelium, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 4| 4| 2| 4| 4| 4| 1| 4| 2| 4| 4| 4| 4| 8| 1| 4| 4| 4| 4| 4| 4| 7| 4| 8| 4| |
| 2| 2| 4| 2| 2| 2| 5| 2| 4| 2| 2| 2| 2| 9| 3| 2| 2| 2| 2| 2| 2| 9| 2| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 | 1 1.0|
Hydronephrosis | 4 | 1 4.0|
Inflammation, Subacute | | 1 2.0|
Metaplasia, Osseous | | 1 1.0|
Glomerulus, Amyloid Deposition | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 4| 4| 6| 4| 9| 4| 4| 4| 4| 0| 4| 4| 4| 4| 5| 3| 4| 4| 4| 4| 1| 4| 4| 4| 4|
| 4| 4| 5| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 4| 4| 4| 4| 6| 4| 4| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + |
Dilatation | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
Prolapse | 4 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + |
Cytologic Alterations | |
Focal Cellular Change | |
__________________________________________________________________________|
Pancreas | + + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
Hemorrhage | |
__________________________________________________________________________|
Stomach | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + |
Hyperkeratosis | 3 |
Hyperplasia, Lymphoid | 2 |
Ulcer | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + M + M + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia | 4 3 1 1 4 3 1|
Pigmentation | 3 |
Pars Distalis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 4| 4| 6| 4| 9| 4| 4| 4| 4| 0| 4| 4| 4| 4| 5| 3| 4| 4| 4| 4| 1| 4| 4| 4| 4|
| 4| 4| 5| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 4| 4| 4| 4| 6| 4| 4| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + |
Inflammation, Chronic | 4 |
Follicular Cell, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + M + + + |
Cyst | 3 3 1 1 4 |
Cyst, Multiple | |
Mineralization | 3 2 |
Pigmentation | 4 |
Germinal Epithelium, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + |
Dilatation | |
Endometrium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | |
Mesenteric, Congestion | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 3 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Thymus | + + + + M + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + |
Alopecia | 2 2 2 |
Edema | |
Inflammation, Chronic | 2 |
Inflammation, Necrotizing | 4 |
Sebaceous Gland, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 4| 4| 6| 4| 9| 4| 4| 4| 4| 0| 4| 4| 4| 4| 5| 3| 4| 4| 4| 4| 1| 4| 4| 4| 4|
| 4| 4| 5| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 4| 4| 4| 4| 6| 4| 4| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Hemorrhage, Acute, Multifocal | 4 |
Mineralization | 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | |
Inflammation, Granulomatous | 2 |
Inflammation, Subacute | |
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 2 2 1 2 1 3 1 3 2 2 3 1 1 3 2 1 1 2 2 2 3|
Olfactory Epithelium, Metaplasia, | |
Focal | 2 2 1 2 2 2 1 1 1 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 2 1 2 2 2 2 2 2 2 1 1 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + |
Hemorrhage, Acute | |
Hydronephrosis | |
Renal Tubule, Degeneration, Hyaline | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 6| |
DAY ON TEST | 4| 9| 8| 4| 4| 4| 4| 4| 4| 6| 0| 4| 4| 4| 4| 4| 1| 4| 9| 4| 8| 4| 4| 4| 9| |
| 4| 2| 1| 4| 4| 4| 4| 4| 4| 1| 7| 4| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + +| 15 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + +| 13 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + +| 15 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + +| 15 |
Prolapse | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + +| 19 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + +| 14 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + +| 14 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + +| 18 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + +| 20 |
Cytologic Alterations | 3 | 1 3.0|
Focal Cellular Change | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + +| 14 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + +| 19 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + +| 19 |
Hyperkeratosis | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Ulcer | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + +| 17 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + +| 16 |
Hypertrophy, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + +| 16 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + M M M| 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 6| |
DAY ON TEST | 4| 9| 8| 4| 4| 4| 4| 4| 4| 6| 0| 4| 4| 4| 4| 4| 1| 4| 9| 4| 8| 4| 4| 4| 9| |
| 4| 2| 1| 4| 4| 4| 4| 4| 4| 1| 7| 4| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + M + + + + + + + + + + + + + + + + + + +| 46 |
Congestion | 2 | 1 2.0|
Hyperplasia | 3 3 3 2 1 2 3 3 1 2| 17 2.4|
Pigmentation | | 1 3.0|
Pars Distalis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + +| 18 |
Inflammation, Chronic | | 1 4.0|
Follicular Cell, Cyst | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + +| 26 |
Cyst | 2 2 2 2 2 3 1 | 12 2.2|
Cyst, Multiple | X | 1 |
Mineralization | | 2 2.5|
Pigmentation | | 1 4.0|
Germinal Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + +| 19 |
Dilatation | 4 | 1 4.0|
Endometrium, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + M + +| 29 |
Iliac, Hyperplasia, Lymphoid | 4 | 1 4.0|
Mesenteric, Congestion | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + M + +| 20 |
Hyperplasia, Lymphoid | 4 4 | 3 3.7|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + +| 19 |
Hyperplasia, Lymphoid | 4 3 4 | 3 3.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + +| 25 |
Hematopoietic Cell Proliferation | 3 | 2 3.0|
Hyperplasia, Lymphoid | 3 3| 3 3.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + +| 14 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 6| |
DAY ON TEST | 4| 9| 8| 4| 4| 4| 4| 4| 4| 6| 0| 4| 4| 4| 4| 4| 1| 4| 9| 4| 8| 4| 4| 4| 9| |
| 4| 2| 1| 4| 4| 4| 4| 4| 4| 1| 7| 4| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + +| 14 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + +| 23 |
Alopecia | 2 2 2 | 6 2.0|
Edema | 2 | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Necrotizing | | 1 4.0|
Sebaceous Gland, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + +| 15 |
Hemorrhage, Acute, Multifocal | | 1 4.0|
Mineralization | 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + +| 14 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + +| 27 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Inflammation, Granulomatous | 1 | 2 1.5|
Inflammation, Subacute | 2 | 1 2.0|
Thrombosis | 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 2 1 2 2 1 | 7 1.9|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 2 2 2 2 2 3 2 2 2 1 2 1 2 2 3 2 2 1 2| 43 1.9|
Olfactory Epithelium, Metaplasia, | | |
Focal | 2 2 2 1 1 1 2 1 2 1 2| 21 1.6|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 2 2 2 2 2 1 1 2 2 2 1 | 28 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + +| 19 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 3| 7| 7| 7| 6| |
DAY ON TEST | 4| 9| 8| 4| 4| 4| 4| 4| 4| 6| 0| 4| 4| 4| 4| 4| 1| 4| 9| 4| 8| 4| 4| 4| 9| |
| 4| 2| 1| 4| 4| 4| 4| 4| 4| 1| 7| 4| 4| 4| 4| 4| 6| 4| 3| 4| 4| 4| 4| 4| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hemorrhage, Acute | 2 | 1 2.0|
Hydronephrosis | 2 | 1 2.0|
Renal Tubule, Degeneration, Hyaline | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + +| 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 4|
DAY ON TEST | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 0| 4| 4| 4| 2| 2|
| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 1| 5| 5| 2| 9| 5| 5| 5| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
3.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + M + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 2 2 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Subacute | 2 3 |
Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Hypoplasia | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Inflammation, Subacute | |
Inflammation, Suppurative | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
__________________________________________________________________________|
Tooth | + + |
Developmental Malformation | X 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Hyperplasia | |
Hypertrophy, Focal | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M M + M M M M M + + M M M + + M + + + + M + M|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 4|
DAY ON TEST | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 0| 4| 4| 4| 2| 2|
| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 1| 5| 5| 2| 9| 5| 5| 5| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
3.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia | 3 2 4 2 2 4 4 3 1 2 4 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Follicular Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 2 4 |
Hemorrhage | |
Rete Ovarii, Hyperplasia | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | 4 |
Prolapse | |
Thrombosis | 2 |
Artery, Thrombosis | 3 |
Endometrium, Hyperplasia | 1 1 3 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | 4 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Atrophy | 3 |
Hyperplasia, Lymphoid | 3 2 3 3 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia, Lymphoid | 3 2 |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + M + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 4|
DAY ON TEST | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 0| 4| 4| 4| 2| 2|
| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 1| 5| 5| 2| 9| 5| 5| 5| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
3.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Duct, Dilatation, Multifocal | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 1 1 |
Edema | 4 |
Inflammation, Chronic | 3 |
Inflammation, Necrotizing | |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Costochondral Junction, Degeneration | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 2 2 2 2 1 3 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Lymphocyte | |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Granulomatous | |
Inflammation, Subacute | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 3 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 |
Olfactory Epithelium, Metaplasia, | |
Focal | 3 2 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 1 1 2 2 2 2 2 2 1 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
Respiratory Epithelium, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 4| 4|
DAY ON TEST | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 6| 4| 4| 4| 0| 4| 4| 4| 2| 2|
| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 1| 5| 5| 2| 9| 5| 5| 5| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
3.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Subacute | 4 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 3| |
DAY ON TEST | 9| 4| 6| 7| 4| 4| 4| 4| 9| 2| 4| 4| 4| 4| 3| 9| 4| 8| 4| 4| 4| 4| 8| 4| 4| |
| 3| 5| 8| 2| 5| 5| 5| 5| 2| 8| 5| 5| 5| 5| 0| 3| 5| 0| 5| 5| 5| 5| 5| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
3.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Focal Cellular Change | | 2 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Subacute | 2 | 3 2.3|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Hypoplasia | 4 | 1 4.0|
Duct, Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Hyperkeratosis | 3 2 | 3 2.7|
Inflammation, Subacute | 3 | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 3 |
Developmental Malformation | X | 3 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 1.0|
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 3| |
DAY ON TEST | 9| 4| 6| 7| 4| 4| 4| 4| 9| 2| 4| 4| 4| 4| 3| 9| 4| 8| 4| 4| 4| 4| 8| 4| 4| |
| 3| 5| 8| 2| 5| 5| 5| 5| 2| 8| 5| 5| 5| 5| 0| 3| 5| 0| 5| 5| 5| 5| 5| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
3.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hypertrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + M + M M + + + + + + + + + + M M + M M| 29 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Congestion | 4 | 1 4.0|
Hyperplasia | 4 2 4 3 2 4 3 2 2 1 | 22 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
Follicular Cell, Hyperplasia | 1 3 3 3 | 6 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X 2 1 3 1 4 2 | 11 2.5|
Hemorrhage | 2 | 1 2.0|
Rete Ovarii, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 4.0|
Prolapse | 4 | 1 4.0|
Thrombosis | | 1 2.0|
Artery, Thrombosis | | 1 3.0|
Endometrium, Hyperplasia | 2 2 3 4 2 | 8 2.3|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Iliac, Hyperplasia, Lymphoid | | 1 4.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M M + + + + + + + + + + + + + + + + + + + M M| 45 |
Atrophy | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 3| |
DAY ON TEST | 9| 4| 6| 7| 4| 4| 4| 4| 9| 2| 4| 4| 4| 4| 3| 9| 4| 8| 4| 4| 4| 4| 8| 4| 4| |
| 3| 5| 8| 2| 5| 5| 5| 5| 2| 8| 5| 5| 5| 5| 0| 3| 5| 0| 5| 5| 5| 5| 5| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
3.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 2 2 4 | 7 2.7|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 2 3.5|
Hyperplasia, Lymphoid | 3 3 1 | 5 2.4|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + M M + + + + + + + + + + + + + + M + + + + + M +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + M| 45 |
Duct, Dilatation, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Alopecia | 2 2 2 1 | 6 1.5|
Edema | 2 | 2 3.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Necrotizing | 4| 1 4.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Costochondral Junction, Degeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 2 2 3 2 2 2 | 16 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Granulomatous | 2 3 1 | 3 2.0|
Inflammation, Subacute | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 2 2 2 4| 8 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 6| 7| 2| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 3| |
DAY ON TEST | 9| 4| 6| 7| 4| 4| 4| 4| 9| 2| 4| 4| 4| 4| 3| 9| 4| 8| 4| 4| 4| 4| 8| 4| 4| |
| 3| 5| 8| 2| 5| 5| 5| 5| 2| 8| 5| 5| 5| 5| 0| 3| 5| 0| 5| 5| 5| 5| 5| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
3.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 2 2 3 3 3 3 2 2 3 3 3 3 3 3 3 3 2 3 3 3 3 3| 47 2.8|
Olfactory Epithelium, Metaplasia, | | |
Focal | 1 1 2 1 1 1 2 1 2 | 12 1.6|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 1 2 2 1 2 2 | 19 1.8|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
Respiratory Epithelium, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Inflammation, Subacute | | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 3| 4| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 4| 0| 4| 4| 4| 4| 1| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 5| 0| 4| 5| 4| 4| 4| 9|
| 2| 8| 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 9| 2| 1| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + M + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4|
Focal Cellular Change | 2 |
Infarct | |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + M M + + + + + M + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Stomach, Glandular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Subserosa, Cyst | |
__________________________________________________________________________|
Tooth | + |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hypertrophy, Focal | 2 2 2 2 1 2 2 1 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + M + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + M M M M M + + M M + M M + + M M M M + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 3| 4| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 4| 0| 4| 4| 4| 4| 1| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 5| 0| 4| 5| 4| 4| 4| 9|
| 2| 8| 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 9| 2| 1| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + +|
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 4 4|
Duct, Dilatation | 2 3 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + M M + + + + + + + +|
Inflammation, Suppurative | 2|
__________________________________________________________________________|
Seminal Vesicle | |
Inflammation, Chronic | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + + + + + M + + M + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + M M + + + + + + +|
Hyperplasia, Lymphoid | 4 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2|
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + M + + M M + + + + + M M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 2 |
Inflammation, Suppurative | 4 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 3 2 2 2 2 2 2 2 3 1 2 2 3 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 3| 4| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 4| 0| 4| 4| 4| 4| 1| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 5| 0| 4| 5| 4| 4| 4| 9|
| 2| 8| 2| 2| 2| 2| 0| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 9| 2| 1| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Subacute | 2 1 4 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia | 2 2 2 2 2 |
Pleura, Inflammation, Subacute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 2 |
Olfactory Epithelium, Metaplasia, | |
Focal | 2 2 2 2 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 |
Respiratory Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium, Acute | 4 |
Fibrosis, Focal | 3|
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic, Focal | 4 |
Metaplasia, Osseous | |
Nephropathy | 2 |
Pelvis, Inflammation, Chronic | |
Renal Tubule, Regeneration, Focal | |
Renal Tubule, Regeneration | 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | |
Dilatation | 4 |
Inflammation, Subacute | 3|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| |
DAY ON TEST | 7| 4| 4| 4| 4| 7| 4| 0| 6| 4| 4| 4| 8| 4| 4| 4| 4| 3| 4| 4| 0| 4| 0| 3| 7| |
| 8| 2| 2| 2| 2| 3| 2| 6| 7| 2| 2| 2| 9| 2| 2| 2| 2| 0| 2| 2| 9| 2| 8| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + M + M + + + + M + + + + + + M + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 4.0|
Focal Cellular Change | | 1 2.0|
Infarct | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Inflammation, Subacute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 2 2.5|
Subserosa, Cyst | X | 1 |
__________________________________________________________________________|____________|
Tooth | + | 2 |
Inflammation, Suppurative | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 1 | 2 1.5|
Hypertrophy, Focal | 2 2 2 2 2 2 | 16 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| |
DAY ON TEST | 7| 4| 4| 4| 4| 7| 4| 0| 6| 4| 4| 4| 8| 4| 4| 4| 4| 3| 4| 4| 0| 4| 0| 3| 7| |
| 8| 2| 2| 2| 2| 3| 2| 6| 7| 2| 2| 2| 9| 2| 2| 2| 2| 0| 2| 2| 9| 2| 8| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + M + M M + M M M M M M + + M M M M +| 20 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 13 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | 3 4 3 | 5 3.6|
Duct, Dilatation | 4 3 3 3 | 6 3.0|
Duct, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 4 | 2 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Neutrophil | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mesenteric, Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M + + + M + + + + + + + + + + + + + + + + + M| 43 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M + + + + + + + + M + + + + + + + + + + + + +| 43 |
Hyperplasia, Lymphoid | 3 | 3 3.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + + + + + + + M + M +| 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M M + M M M M M M M M M M M M M M M M M M M| 2 |
__________________________________________________________________________|____________|
Skin | + + + M + + M + + + + + + + + + + + + + + + + + +| 48 |
Alopecia | 3 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| |
DAY ON TEST | 7| 4| 4| 4| 4| 7| 4| 0| 6| 4| 4| 4| 8| 4| 4| 4| 4| 3| 4| 4| 0| 4| 0| 3| 7| |
| 8| 2| 2| 2| 2| 3| 2| 6| 7| 2| 2| 2| 9| 2| 2| 2| 2| 0| 2| 2| 9| 2| 8| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 4 | 2 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 2 2 1 1 1 2 2 2 2 2 2 2 | 30 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 3 | 2 2.5|
Infiltration Cellular, Histiocyte | 3 | 2 2.5|
Inflammation, Subacute | 3 | 4 2.5|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 3 | 7 2.1|
Pleura, Inflammation, Subacute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 1 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 | 3 1.7|
Olfactory Epithelium, Metaplasia, | | |
Focal | 2 1 2 | 8 1.8|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 2 1 | 5 1.4|
Respiratory Epithelium, Hyperplasia, | | |
Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium, Acute | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 5| |
DAY ON TEST | 7| 4| 4| 4| 4| 7| 4| 0| 6| 4| 4| 4| 8| 4| 4| 4| 4| 3| 4| 4| 0| 4| 0| 3| 7| |
| 8| 2| 2| 2| 2| 3| 2| 6| 7| 2| 2| 2| 9| 2| 2| 2| 2| 0| 2| 2| 9| 2| 8| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Fibrosis, Focal | | 1 3.0|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
Inflammation, Chronic, Focal | | 1 4.0|
Metaplasia, Osseous | 3 | 1 3.0|
Nephropathy | | 1 2.0|
Pelvis, Inflammation, Chronic | 3 3 | 2 3.0|
Renal Tubule, Regeneration, Focal | 2 | 1 2.0|
Renal Tubule, Regeneration | | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Concretion | 3 | 1 3.0|
Dilatation | | 1 4.0|
Inflammation, Subacute | | 1 3.0|
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 4| 6| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 4| 4| 5| 4| 5| 4| 1| 5| 6| 2| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2|
| 3| 3| 9| 3| 6| 3| 9| 4| 8| 0| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + +|
Focal Cellular Change | 3 |
Infarct | 2 |
Inflammation, Subacute | 3 |
Necrosis | 4 |
Serosa, Fibrosis, Chronic | 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + M + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 |
Hyperplasia | |
Hypertrophy, Diffuse | 1 |
Hypertrophy, Focal | 1 1 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M M M M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + M + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 4| 6| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 4| 4| 5| 4| 5| 4| 1| 5| 6| 2| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2|
| 3| 3| 9| 3| 6| 3| 9| 4| 8| 0| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + M + + +|
__________________________________________________________________________|
Penis | + |
Abscess | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 4 3 4|
Duct, Dilatation | 4 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + |
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + +|
Hyperplasia, Neutrophil | 4 |
__________________________________________________________________________|
Lymph Node | + M + + + M + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | |
Mesenteric, Sinus, Dilatation | 4 |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + M + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + M + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + +|
Atrophy | 2 |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + M + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + +|
Alopecia | 2 |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + +|
Abscess | |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 4| 6| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 4| 4| 5| 4| 5| 4| 1| 5| 6| 2| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2|
| 3| 3| 9| 3| 6| 3| 9| 4| 8| 0| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 3 |
Infiltration Cellular, Histiocyte | 2 2 2 |
Inflammation, Subacute | 2 |
Inflammation, Suppurative | 1 2 2 |
Alveolar Epithelium, Hyperplasia | |
Bronchiole, Hyperplasia, Focal | 4 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 3 |
Inflammation, Suppurative | 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 2 1 2 |
Olfactory Epithelium, Metaplasia, | |
Focal | 1 1 1 1 1 2 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 |
Respiratory Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + +|
Atrophy | |
Developmental Malformation | |
Inflammation, Suppurative | 3 |
Mineralization | 2 |
Pelvis, Inflammation, Chronic | 4|
Pelvis, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + +|
Dilatation | 3 |
Hyperplasia | 4|
Inflammation, Subacute | 3|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 4| 7| 4| 7| 5| 5| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 6| 8| 4| 4| 4| 4| 9| 4| 2| 4| 7| 4| |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9| 3| 3| 3| 3| 8| 3| 4| 3| 1| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + +| 16 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M + +| 14 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + M + M M + +| 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + +| 15 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + +| 18 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + +| 17 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + +| 17 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + +| 25 |
Focal Cellular Change | | 1 3.0|
Infarct | | 1 2.0|
Inflammation, Subacute | | 1 3.0|
Necrosis | 4 | 2 4.0|
Serosa, Fibrosis, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + +| 16 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + +| 15 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + +| 18 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + +| 16 |
Hyperkeratosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + +| 16 |
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Tooth | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + +| 16 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +| 32 |
Hyperplasia, Focal | 1 1 | 4 1.3|
Hyperplasia | 2 | 1 2.0|
Hypertrophy, Diffuse | | 1 1.0|
Hypertrophy, Focal | 2 1 2 2 1 1 1 1 1 2 | 12 1.3|
Hypertrophy | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + +| 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 4| 7| 4| 7| 5| 5| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 6| 8| 4| 4| 4| 4| 9| 4| 2| 4| 7| 4| |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9| 3| 3| 3| 3| 8| 3| 4| 3| 1| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + +| 16 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + + + +| 5 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + +| 16 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + +| 15 |
__________________________________________________________________________|____________|
Penis | + | 2 |
Abscess | | 1 3.0|
Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + +| 9 |
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | 3 | 4 3.5|
Duct, Dilatation | 3| 4 3.8|
__________________________________________________________________________|____________|
Prostate | + + + M M + +| 13 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 4 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + +| 15 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + +| 16 |
Hyperplasia, Neutrophil | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + +| 20 |
Mediastinal, Hyperplasia, Lymphoid | 4 | 1 4.0|
Mesenteric, Sinus, Dilatation | | 1 4.0|
Renal, Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + M + +| 13 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + +| 12 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + +| 20 |
Atrophy | | 1 2.0|
Hematopoietic Cell Proliferation | 4| 2 3.5|
__________________________________________________________________________|____________|
Thymus | + + + M M + +| 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 4| 7| 4| 7| 5| 5| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 6| 8| 4| 4| 4| 4| 9| 4| 2| 4| 7| 4| |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9| 3| 3| 3| 3| 8| 3| 4| 3| 1| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M M M M M| 3 |
__________________________________________________________________________|____________|
Skin | + + + M + + + + + + + +| 21 |
Alopecia | 2 2 2 | 4 2.0|
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + +| 16 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + +| 16 |
Abscess | 4 | 1 4.0|
Mineralization | 2| 2 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + +| 16 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + +| 32 |
Hemorrhage, Acute | | 1 3.0|
Infiltration Cellular, Histiocyte | | 3 2.0|
Inflammation, Subacute | | 1 2.0|
Inflammation, Suppurative | | 3 1.7|
Alveolar Epithelium, Hyperplasia | 2 3 3 1 2 3| 6 2.3|
Bronchiole, Hyperplasia, Focal | 1 3 | 5 2.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Acute | | 1 3.0|
Inflammation, Suppurative | 2 1 1 | 4 1.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 3.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 2 1 2 1 2 2 2 1 | 17 1.5|
Olfactory Epithelium, Metaplasia, | | |
Focal | 2 1 1 1 | 11 1.3|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 | 2 1.5|
Respiratory Epithelium, Hyperplasia, | | |
Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + +| 16 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 4| 7| 4| 7| 5| 5| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 6| 8| 4| 4| 4| 4| 9| 4| 2| 4| 7| 4| |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9| 3| 3| 3| 3| 8| 3| 4| 3| 1| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + +| 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + +| 16 |
Atrophy | 4 | 1 4.0|
Developmental Malformation | X | 1 |
Inflammation, Suppurative | | 1 3.0|
Mineralization | | 1 2.0|
Pelvis, Inflammation, Chronic | 4 | 2 4.0|
Pelvis, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + +| 16 |
Dilatation | | 1 3.0|
Hyperplasia | | 1 4.0|
Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 3| 7| 6| 7| 7| 7| 7| 4| 7| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 5| 4| 9| 4| 4| 4| 4| 3| 4| 4| 4| 4| 2| 0| 8| 4| 4| 3| 4| 4| 4| 0| 4| 4| 4|
| 3| 1| 4| 1| 1| 5| 1| 7| 1| 1| 1| 1| 1| 2| 1| 1| 1| 8| 1| 1| 1| 4| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
3.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + + M + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + M + + + + + + M + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 2 |
Hemorrhage | 4 |
Infarct | 3 4 |
Inflammation, Subacute | 1 |
Bile Duct, Cyst | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Inflammation, Subacute | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
__________________________________________________________________________|
Tooth | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Diffuse | 2 |
Hyperplasia, Focal | |
Hyperplasia | 2 2|
Hypertrophy, Diffuse | 2 1 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 3| 7| 6| 7| 7| 7| 7| 4| 7| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 5| 4| 9| 4| 4| 4| 4| 3| 4| 4| 4| 4| 2| 0| 8| 4| 4| 3| 4| 4| 4| 0| 4| 4| 4|
| 3| 1| 4| 1| 1| 5| 1| 7| 1| 1| 1| 1| 1| 2| 1| 1| 1| 8| 1| 1| 1| 4| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
3.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy, Focal | 2 1 1 2 1|
Hypertrophy | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + + + M + M + M + M M M M + M + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + |
Inflammation, Suppurative | 4 4 |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + M + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + M + + + + + + M + + + M + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + M M M + + + + + + + + M + M + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M M M M M M M M M M M M M M M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + M + + + + + + + + + + + +|
Alopecia | 1 |
Inflammation, Necrotizing | 3 |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 3| 7| 6| 7| 7| 7| 7| 4| 7| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 5| 4| 9| 4| 4| 4| 4| 3| 4| 4| 4| 4| 2| 0| 8| 4| 4| 3| 4| 4| 4| 0| 4| 4| 4|
| 3| 1| 4| 1| 1| 5| 1| 7| 1| 1| 1| 1| 1| 2| 1| 1| 1| 8| 1| 1| 1| 4| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
3.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Mineralization | 1 3 3 2 2 2 1 1 2 2 2 1 2 2 1 2 2|
Meninges, Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Focal | 2 2 2 2 |
Inflammation, Subacute | 3 |
Inflammation, Suppurative | 3 |
Leukocytosis | 4 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 |
Alveolar Epithelium, Hyperplasia | 4 2 2 3 |
Bronchiole, Hyperplasia | 2 1 |
Bronchus, Ulcer, Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 2 |
Olfactory Epithelium, Degeneration, | |
Focal, Hyaline | 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 2 3 2 2 2 1 2 2 3 1 2 2 2 2 2 2 1 2 2 2|
Olfactory Epithelium, Metaplasia, | |
Focal | 1 2 1 2|
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Inflammation, Suppurative | 4 |
Metaplasia, Osseous | 2 |
Mineralization | 2 |
Nephropathy | 3 |
Pelvis, Inflammation, Chronic | |
Pelvis, Inflammation, Suppurative | |
Renal Tubule, Casts | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 3| 7| 6| 7| 7| 7| 7| 4| 7| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 5| 4| 9| 4| 4| 4| 4| 3| 4| 4| 4| 4| 2| 0| 8| 4| 4| 3| 4| 4| 4| 0| 4| 4| 4|
| 3| 1| 4| 1| 1| 5| 1| 7| 1| 1| 1| 1| 1| 2| 1| 1| 1| 8| 1| 1| 1| 4| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
3.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Degeneration | 3 |
Renal Tubule, Dilatation | 3 |
Renal Tubule, Regeneration, Focal | |
Renal Tubule, Regeneration | 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 5| 5| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 4| 4| 4| 4| 4| 4| 1| |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 5| 1| 0| 1| 1| 1| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
3.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + + + + M + + + + M + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + M + + + + + + M| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Focal Cellular Change | | 1 2.0|
Hemorrhage | | 1 4.0|
Infarct | 4 | 3 3.7|
Inflammation, Subacute | | 1 1.0|
Bile Duct, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 3 | 2 2.5|
Inflammation, Subacute | 2 | 1 2.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 5| 5| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 4| 4| 4| 4| 4| 4| 1| |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 5| 1| 0| 1| 1| 1| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
3.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Hyperplasia, Diffuse | 1 | 2 1.5|
Hyperplasia, Focal | 2 | 1 2.0|
Hyperplasia | 3 | 3 2.3|
Hypertrophy, Diffuse | 2 | 3 1.7|
Hypertrophy, Focal | 1 2 2 3 1 1 2 1 | 13 1.5|
Hypertrophy | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + M + + + + M + + + + + + + + + + + M| 45 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M M + M + M + M + + + + M + M M M + M + + M| 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 7 |
Inflammation, Suppurative | 2 4 | 4 3.5|
Duct, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + M + + + + + + M + M + + M + + + + + + + +| 41 |
Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | 1 | 2 1.5|
__________________________________________________________________________|____________|
Thymus | + M M + M + + + + + + + M + M M M M M M + + + M +| 33 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 5| 5| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 4| 4| 4| 4| 4| 4| 1| |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 5| 1| 0| 1| 1| 1| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
3.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M + M M M M M M M M M M M M M M M M M M M| 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alopecia | 2 2 | 3 1.7|
Inflammation, Necrotizing | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Mineralization | 2 1 2 1 3 2 2 1 2 2 1 2 2 3| 31 1.8|
Meninges, Hyperplasia, Lymphoid | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + M + + + + + + | 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 4| 2 3.0|
Hemorrhage, Focal | | 4 2.0|
Inflammation, Subacute | 3 | 2 3.0|
Inflammation, Suppurative | | 1 3.0|
Leukocytosis | | 1 4.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 2.0|
Alveolar Epithelium, Hyperplasia | 3 2 | 6 2.7|
Bronchiole, Hyperplasia | | 2 1.5|
Bronchus, Ulcer, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 4 | 3 3.0|
Olfactory Epithelium, Degeneration, | | |
Focal, Hyaline | | 1 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 2 2 | 39 1.9|
Olfactory Epithelium, Metaplasia, | | |
Focal | 1 2 2 1 | 8 1.5|
Respiratory Epithelium, Degeneration,| | |
Hyaline | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05095-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:43:07
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 5| 5| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 4| 4| 4| 4| 4| 4| 1| |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 5| 1| 0| 1| 1| 1| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
3.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | | 1 2.0|
Inflammation, Suppurative | | 1 4.0|
Metaplasia, Osseous | | 1 2.0|
Mineralization | | 1 2.0|
Nephropathy | | 1 3.0|
Pelvis, Inflammation, Chronic | 2 2 | 2 2.0|
Pelvis, Inflammation, Suppurative | 3 | 1 3.0|
Renal Tubule, Casts | 3 2| 2 2.5|
Renal Tubule, Degeneration | 3 | 2 3.0|
Renal Tubule, Dilatation | | 1 3.0|
Renal Tubule, Regeneration, Focal | 2 | 1 2.0|
Renal Tubule, Regeneration | 2 | 3 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
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