TR 380 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/13/94
EXP: 05095 EPINEPHRINE HCL TIME: 01:00:21
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 55663
CONT: N01-ES-38061 CAS: 55-31-2
PATHOLOGIST: E. GIDDENS S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/13/94
EXP: 05095 EPINEPHRINE HCL TIME: 01:00:21
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 55663
CONT: N01-ES-38061 CAS: 55-31-2
PATHOLOGIST: E. GIDDENS S. EUSTIS
EPINEPHRINE HCL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 741 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 352 409 551 567 570 573 578 606 610 630 |
| 635 686 689 699 708 708 709 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.5MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 220 419 424 456 465 498 525 542 571 640 |
| 654 659 668 672 689 721 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3.0MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 225 345 381 421 510 538 545 553 604 637 |
| 694 702 724 740 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
EPINEPHRINE HCL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 741 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 741 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 96.0 96.0 96.0 86.0 78.0 66.0 |
| | |
| | |
|1.5MG/M3 | 100.0 100.0 98.0 98.0 94.0 90.0 84.0 82.0 76.0 68.0 |
| | |
| | |
|3.0MG/M3 | 100.0 100.0 98.0 96.0 92.0 92.0 86.0 82.0 80.0 72.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 1.5MG/M3 3.0MG/M3 |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.0% 68.0% 72.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.666N P=1.000N P=0.727N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 604.7 551.4 544.2 |
|NATURAL DEATHS (C) | (24.7) (33.5) (41.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 694.7 680.3 685.9 |
|(STANDARD ERROR) | (12.4) (16.4) (17.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
EPINEPHRINE HCL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 742 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 228 324 503 558 566 615 667 679 683 689 |
| 707 713 714 714 720 724 731 732 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.5MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 384 465 504 539 581 607 616 640 658 661 |
| 692 693 693 693 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3.0MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 268 342 421 425 609 661 672 680 685 692 |
| 693 693 704 728 730 731 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
EPINEPHRINE HCL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 742 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 742 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 98.0 96.0 96.0 96.0 94.0 90.0 88.0 64.0 |
| | |
| | |
|1.5MG/M3 | 100.0 100.0 100.0 100.0 98.0 96.0 92.0 90.0 80.0 70.0 |
| | |
| | |
|3.0MG/M3 | 100.0 100.0 98.0 96.0 92.0 92.0 92.0 92.0 88.0 68.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 1.5MG/M3 3.0MG/M3 |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 64.0% 70.0% 68.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.781N P=0.768N P=0.852N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 625.9 609.5 608.4 |
|NATURAL DEATHS (C) | (34.1) (25.2) (38.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 700.2 702.2 699.2 |
|(STANDARD ERROR) | (14.4) (11.4) (14.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
EPINEPHRINE HCL
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
1.5MG/M3 = 2
3.0MG/M3 = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 23 1
|
| 23 31 12
|
96 + 3 3 122 1
|
| 3 2 2 1 1
|
92 + 3 22 3 11
|
P | 2 23 3
E |
R 88 + 2 2 33 11
C |
E | 2 23 1 1
N |
T 84 + 23 2 11
|
S | 2 31 132
U |
R 80 + 112 2 3
V |
I | 1 2 2 1 33
V |
A 76 + 22 11 3 3
L |
| 11 3 3
|
72 + 2 21 1 3
|
| 2 2
|
68 + 2 2
|
| 1 1
|
64 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 6 obs hidden.
EPINEPHRINE HCL
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
1.5MG/M3 = 2
3.0MG/M3 = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 2
|
| 1 3 1 3 2 2
| 1 3 3 2 1
95 +
| 1 2 1
| 3 2 11 2 3
|
P 90 + 1 2 21 3
E |
R | 21 31
C | 2 2 113
E 85 +
N | 2 2 11
T | 2 2 11
|
S 80 + 2 1 1
U |
R | 11
V | 3 3
I 75 +
V | 3 3
A | 2 113 3
L |
70 + 11 2
|
| 1 13
|
65 +
| 11
|
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.
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