TR 380 Rat Pathology Tables
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
Facility: Battelle Northwest
Chemical CAS #: 55-31-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 6| 7| 6| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 7| 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 2| 7|
| 9| 9| 1| 9| 6| 9| 0| 2| 9| 9| 9| 9| 9| 9| 8| 7| 9| 4| 9| 9| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M + + + + + + + + + M + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + A + + + + + M +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X|
Neoplastic Nodule | X |
Neoplastic Nodule, Multiple | |
__________________________________________________________________________|
Mesentery | |
Hemangioma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + M + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 6| 7| 6| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 7| 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 2| 7|
| 9| 9| 1| 9| 6| 9| 0| 2| 9| 9| 9| 9| 9| 9| 8| 7| 9| 4| 9| 9| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Carcinoma | X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
Endometrium, Deciduoma Malignant | X |
Endometrium, Polyp | |
Endometrium, Polyp Stromal | X X X X X X |
Endometrium, Polyp Stromal, Multiple | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Leukemia Mononuclear | X |
Mesenteric, Leukemia Mononuclear | X X X|
Pancreatic, Leukemia Mononuclear | X X|
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + M + + + + + M M M + M M M + + + + +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
Thymoma Benign | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 6| 7| 6| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 7| 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 2| 7|
| 9| 9| 1| 9| 6| 9| 0| 2| 9| 9| 9| 9| 9| 9| 8| 7| 9| 4| 9| 9| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Adenocarcinoma | X |
Fibroadenoma | X X X X X X|
Fibroadenoma, Multiple | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Respiratory Epithelium, Adenoma | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 2| 2| 1| 4| 9| 2| 2| 2| 2| 5| 2| 2| 7| 2| 7| 2| 2| 2| 8| 2| 1| 1| |
| 3| 9| 9| 9| 9| 4| 4| 3| 9| 9| 9| 9| 1| 9| 9| 7| 9| 1| 9| 9| 9| 2| 9| 5| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + A + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + A + + + + + + +| 45 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + A + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X| 24 |
Neoplastic Nodule | | 1 |
Neoplastic Nodule, Multiple | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Hemangioma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X | 8 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 9 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 10 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 2| 2| 1| 4| 9| 2| 2| 2| 2| 5| 2| 2| 7| 2| 7| 2| 2| 2| 8| 2| 1| 1| |
| 3| 9| 9| 9| 9| 4| 4| 3| 9| 9| 9| 9| 1| 9| 9| 7| 9| 1| 9| 9| 9| 2| 9| 5| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + M + + + + M + + + M + M + + M| 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X| 9 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X| 30 |
Pars Distalis, Carcinoma | | 1 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | X X | 4 |
C-Cell, Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | X X | 5 |
Carcinoma | | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granulosa Cell Tumor Malignant | X X | 2 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 5 |
Endometrium, Deciduoma Malignant | | 1 |
Endometrium, Polyp | X | 1 |
Endometrium, Polyp Stromal | X X | 8 |
Endometrium, Polyp Stromal, Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 7 |
__________________________________________________________________________|____________|
Lymph Node | + M + + + + + + + + M + + + + + + + + + + + + + +| 48 |
Mediastinal, Leukemia Mononuclear | X | 2 |
Mesenteric, Leukemia Mononuclear | | 3 |
Pancreatic, Leukemia Mononuclear | | 2 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + M + + + + + + M M + + + + + M + + + + + + +| 37 |
Leukemia Mononuclear | X X X X X X| 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 2| 2| 1| 4| 9| 2| 2| 2| 2| 5| 2| 2| 7| 2| 7| 2| 2| 2| 8| 2| 1| 1| |
| 3| 9| 9| 9| 9| 4| 4| 3| 9| 9| 9| 9| 1| 9| 9| 7| 9| 1| 9| 9| 9| 2| 9| 5| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + M + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X X| 14 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X| 24 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 11 |
Thymoma Benign | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Adenocarcinoma | X | 2 |
Fibroadenoma | X X X | 9 |
Fibroadenoma, Multiple | | 1 |
__________________________________________________________________________|____________|
Skin | + M + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Fibroma | X | 1 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Leukemia Mononuclear | X X X X X X X| 19 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
Respiratory Epithelium, Adenoma | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + + | 5 |
__________________________________________________________________________|____________|
Lacrimal Gland | + + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 2| 2| 1| 4| 9| 2| 2| 2| 2| 5| 2| 2| 7| 2| 7| 2| 2| 2| 8| 2| 1| 1| |
| 3| 9| 9| 9| 9| 4| 4| 3| 9| 9| 9| 9| 1| 9| 9| 7| 9| 1| 9| 9| 9| 2| 9| 5| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Leukemia Mononuclear | | 2 |
Papilloma | X X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X| 24 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 2| 3| 7| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 2| 3| 3| 8|
| 1| 1| 1| 1| 1| 7| 4| 1| 9| 1| 7| 1| 1| 1| 7| 4| 1| 1| 1| 1| 1| 3| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Pancreas | + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + +|
Leukemia Mononuclear | X X|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + +|
Adenoma, Multiple | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + +|
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + M|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 2| 3| 7| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 2| 3| 3| 8|
| 1| 1| 1| 1| 1| 7| 4| 1| 9| 1| 7| 1| 1| 1| 7| 4| 1| 1| 1| 1| 1| 3| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + +|
Granulosa Cell Tumor NOS | X |
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Uterus | + + + + + + + + + +|
Leiomyoma | X |
Leukemia Mononuclear | X |
Endometrium, Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Mediastinal, Leukemia Mononuclear | |
Mesenteric, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + + + M +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + M|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + +|
Adenocarcinoma | X X |
Fibroadenoma | X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + +|
Fibroma | X |
Fibrous Histiocytoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
Glioma NOS, Marked | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 2| 3| 7| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 2| 3| 3| 8|
| 1| 1| 1| 1| 1| 7| 4| 1| 9| 1| 7| 1| 1| 1| 7| 4| 1| 1| 1| 1| 1| 3| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + +|
__________________________________________________________________________|
Lacrimal Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 1| 5| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| |
DAY ON TEST | 5| 3| 2| 3| 3| 2| 2| 3| 1| 5| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 5| 2| 5| |
| 3| 1| 8| 1| 1| 0| 6| 5| 4| 3| 0| 1| 1| 1| 1| 9| 1| 1| 1| 4| 1| 1| 3| 0| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Intestine Large | + + + A + + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + M + + + M + + + + A| 17 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Intestine Small | + + + A + + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + + + A| 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + + + A| 19 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + +| 31 |
Leukemia Mononuclear | X X X X X X X X X X | 18 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + +| 21 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + +| 21 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + +| 21 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + +| 23 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + +| 23 |
Leukemia Mononuclear | X X X X X X X X | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + + + + + + + +| 22 |
Leukemia Mononuclear | X X X X X X | 8 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + +| 22 |
Adenoma, Multiple | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +| 38 |
Leukemia Mononuclear | X X X X | 6 |
Pars Distalis, Adenoma | X X X X X X X X X | 25 |
Pars Distalis, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + +| 21 |
C-Cell, Adenoma | X X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 1| 5| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| |
DAY ON TEST | 5| 3| 2| 3| 3| 2| 2| 3| 1| 5| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 5| 2| 5| |
| 3| 1| 8| 1| 1| 0| 6| 5| 4| 3| 0| 1| 1| 1| 1| 9| 1| 1| 1| 4| 1| 1| 3| 0| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + M + + +| 21 |
Adenoma | | 1 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + +| 22 |
Granulosa Cell Tumor NOS | | 1 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + +| 25 |
Leiomyoma | | 1 |
Leukemia Mononuclear | | 1 |
Endometrium, Polyp Stromal | X X X | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + +| 21 |
Leukemia Mononuclear | X X X X | 7 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + +| 22 |
Mediastinal, Leukemia Mononuclear | X | 1 |
Mesenteric, Leukemia Mononuclear | X X | 2 |
Renal, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + M + + + + + + + +| 18 |
Leukemia Mononuclear | X X X X X X | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + M + +| 17 |
Leukemia Mononuclear | X X X X X X | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + +| 26 |
Leukemia Mononuclear | X X X X X X X X X X | 18 |
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + +| 19 |
Leukemia Mononuclear | X X X X | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + +| 28 |
Adenocarcinoma | X | 3 |
Fibroadenoma | X X X X X X X | 11 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + +| 22 |
Fibroma | | 1 |
Fibrous Histiocytoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + +| 21 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 1| 5| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| |
DAY ON TEST | 5| 3| 2| 3| 3| 2| 2| 3| 1| 5| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 5| 2| 5| |
| 3| 1| 8| 1| 1| 0| 6| 5| 4| 3| 0| 1| 1| 1| 1| 9| 1| 1| 1| 4| 1| 1| 3| 0| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + +| 21 |
Carcinoma, Metastatic, Pituitary | | |
Gland | X | 1 |
Glioma NOS, Marked | X| 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + +| 23 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X | 15 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + +| 21 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 7 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Squamous Cell Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + +| 23 |
Leukemia Mononuclear | X X X X | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + +| 21 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 3| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 3| 3| 3| 8| 3| 3| 3| 5| 3| 1| 3| 2| 3| 7| 5| 3| 4| 3| 1| 3| 3|
| 0| 0| 5| 4| 7| 0| 0| 1| 0| 0| 0| 7| 0| 5| 0| 2| 0| 2| 6| 0| 4| 0| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + A + + A + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + A + + + A + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + A + + + A + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + A + + + A + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + A + + A + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + A + + + A + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + A + + + A + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + A + + + A + + A + + + + + +|
Adenocarcinoma | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + A + + + A + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + A + + + A + + A + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Neoplastic Nodule | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + M + + + A + + M + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + A + + A + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + A + + A + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + A + + A + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + A + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + A + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + A + + + A + + A + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + A + + + A + + A + + + + + +|
Adenoma | X|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + A + + + A + + A + + + + + +|
Leukemia Mononuclear | X X X X |
Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + + + A + + M + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + A + + M + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + A + + A + + + + + +|
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + A + + + A + + M + + + + + +|
C-Cell, Adenoma | X X X |
C-Cell, Adenoma, Multiple | X |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 3| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 3| 3| 3| 8| 3| 3| 3| 5| 3| 1| 3| 2| 3| 7| 5| 3| 4| 3| 1| 3| 3|
| 0| 0| 5| 4| 7| 0| 0| 1| 0| 0| 0| 7| 0| 5| 0| 2| 0| 2| 6| 0| 4| 0| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + A + + + + + M + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + A + + + M + + A + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + A + + A + + + + + +|
Carcinoma | X |
Endometrium, Polyp Stromal | X X X |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + A + + + A + + A + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + A + + A + + + + + +|
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M M + + + + + + + + A + + M + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + A + + + M + + A + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + A + + + A + + A + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + A + + A + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
Adenocarcinoma | X X X |
Fibroadenoma | X |
Fibroadenoma, Multiple | X X |
__________________________________________________________________________|
Skin | + + + + M + + + + + + + + + + A + + + + + + + + +|
Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + A + + A + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + A + + + + + + + + +|
Glioma NOS, Moderate | X |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 3| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 3| 3| 3| 8| 3| 3| 3| 5| 3| 1| 3| 2| 3| 7| 5| 3| 4| 3| 1| 3| 3|
| 0| 0| 5| 4| 7| 0| 0| 1| 0| 0| 0| 7| 0| 5| 0| 2| 0| 2| 6| 0| 4| 0| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Oligodendroglioma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + A + + + M + + A + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + A + + A + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Bronchus, Carcinoma | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + A + + + A + + A + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + A + + + A + + A + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + A + + A + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + + A + + A + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 6| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 2| 3| 7| 2| 3| 6| 3| |
| 0| 0| 2| 2| 0| 2| 0| 0| 0| 0| 7| 0| 0| 9| 0| 0| 0| 0| 5| 0| 9| 0| 0| 5| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + A + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + A + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + A + + + + + + + A + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + A + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + A + + + + + +| 44 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + A + + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X X X X X X | 16 |
Neoplastic Nodule | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Adenoma | | 1 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X | 5 |
Pheochromocytoma Benign | X | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + M + + + M + + + + + + +| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + I + +| 47 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 6| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 2| 3| 7| 2| 3| 6| 3| |
| 0| 0| 2| 2| 0| 2| 0| 0| 0| 0| 7| 0| 0| 9| 0| 0| 0| 0| 5| 0| 9| 0| 0| 5| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X| 32 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
C-Cell, Adenoma | X | 4 |
C-Cell, Adenoma, Multiple | | 1 |
C-Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Carcinoma | | 1 |
Endometrium, Polyp Stromal | X | 4 |
__________________________________________________________________________|____________|
Vagina | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + + + + + M M M + + M + + + + + M M| 39 |
Leukemia Mononuclear | X X X | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M + + + + + + + + + + + + + + + + + + + + + +| 45 |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X X X X X X | 16 |
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenocarcinoma | X| 4 |
Fibroadenoma | X X X X X X X X | 9 |
Fibroadenoma, Multiple | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 6| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 2| 3| 7| 2| 3| 6| 3| |
| 0| 0| 2| 2| 0| 2| 0| 0| 0| 0| 7| 0| 0| 9| 0| 0| 0| 0| 5| 0| 9| 0| 0| 5| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Fibroma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Glioma NOS, Moderate | | 1 |
Oligodendroglioma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X | 11 |
Bronchus, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + A + + + + + +| 46 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 4| 6| 2| 2| 2| 5| 2| 2| 2| 2| 2| 5| 2| 2| 0| 1| 2| 2| 1| 2| 9| 1| 2|
| 9| 9| 0| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 9| 9| 7| 7| 9| 9| 7| 9| 3| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
Neoplastic Nodule | |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + M + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Sarcoma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Schwannoma NOS | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X X X X X |
Pheochromocytoma Benign, Multiple | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 4| 6| 2| 2| 2| 5| 2| 2| 2| 2| 2| 5| 2| 2| 0| 1| 2| 2| 1| 2| 9| 1| 2|
| 9| 9| 0| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 9| 9| 7| 7| 9| 9| 7| 9| 3| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X X X X |
C-Cell, Adenoma, Multiple | X |
C-Cell, Carcinoma | X X|
Follicular Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + M + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
Interstitial Cell, Adenoma | X X X X X X X|
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Mesenteric, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + M + + M + + + + M + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + M|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + M + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 4| 6| 2| 2| 2| 5| 2| 2| 2| 2| 2| 5| 2| 2| 0| 1| 2| 2| 1| 2| 9| 1| 2|
| 9| 9| 0| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 9| 9| 7| 7| 9| 9| 7| 9| 3| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M + + + + M + + M + M + + M M + + + + + + +|
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
Keratoacanthoma | X |
Trichoepithelioma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Oligodendroglioma Benign | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | |
Sarcoma | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 9| 2| 1| 2| 2| 0| 2| 7| 2| 2| 1| 2| 0| 1| 2| |
| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 6| 9| 7| 9| 9| 2| 9| 9| 9| 9| 7| 9| 7| 4| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + M + M + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X | 18 |
Neoplastic Nodule | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 2 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
Schwannoma NOS | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 7 |
Pheochromocytoma Benign | X X X X | 9 |
Pheochromocytoma Benign, Multiple | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 9| 2| 1| 2| 2| 0| 2| 7| 2| 2| 1| 2| 0| 1| 2| |
| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 6| 9| 7| 9| 9| 2| 9| 9| 9| 9| 7| 9| 7| 4| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X X | 5 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + M M M + + M + + + + + + + + +| 43 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X | 34 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 2 |
C-Cell, Adenoma | X X X| 7 |
C-Cell, Adenoma, Multiple | X | 2 |
C-Cell, Carcinoma | X X | 4 |
Follicular Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + M + + + + + + + M + + + + + M + + + +| 46 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Adenoma | X X | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | X | 1 |
Interstitial Cell, Adenoma | X X X X X X X | 14 |
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X| 25 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 6 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Leukemia Mononuclear | | 1 |
Mediastinal, Leukemia Mononuclear | | 1 |
Mesenteric, Leukemia Mononuclear | X X | 2 |
Pancreatic, Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 9| 2| 1| 2| 2| 0| 2| 7| 2| 2| 1| 2| 0| 1| 2| |
| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 6| 9| 7| 9| 9| 2| 9| 9| 9| 9| 7| 9| 7| 4| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + M + + + + + + + + + + + + + + M + + +| 44 |
Leukemia Mononuclear | X X X X X X X X | 13 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X | 11 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X | 18 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + + + + M + + +| 46 |
Leukemia Mononuclear | X X X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + M + + + + M + + + + + + + M + M M + + + + M| 35 |
Fibroadenoma | X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibroma | X X X X| 5 |
Keratoacanthoma | X | 2 |
Trichoepithelioma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
Oligodendroglioma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X | 4 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X | 18 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
Leukemia Mononuclear | X X | 2 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 9| 2| 1| 2| 2| 0| 2| 7| 2| 2| 1| 2| 0| 1| 2| |
| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 6| 9| 7| 9| 9| 2| 9| 9| 9| 9| 7| 9| 7| 4| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 4 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 7 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X | 19 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 7| 5| 7| 1| 7| 3| 3| 3| 5| 3| 3| 0| 3| 8| 3| 3| 3| 6| 3| 9| 3| 3| 8| 3|
| 1| 2| 1| 7| 0| 2| 1| 1| 1| 9| 1| 1| 2| 1| 1| 1| 1| 1| 8| 1| 3| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + A + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + A + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + A + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + A + + |
__________________________________________________________________________|
Intestine Small | + + + A + + + + A + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + A + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + A + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + A + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + |
Leukemia Monocytic | |
Leukemia Mononuclear | X X X X X X X X |
Neoplastic Nodule | |
__________________________________________________________________________|
Mesentery | + |
Sarcoma | |
Schwannoma NOS | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X |
Pheochromocytoma Benign, Multiple | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + |
Adenoma | |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M M + + + |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 7| 5| 7| 1| 7| 3| 3| 3| 5| 3| 3| 0| 3| 8| 3| 3| 3| 6| 3| 9| 3| 3| 8| 3|
| 1| 2| 1| 7| 0| 2| 1| 1| 1| 9| 1| 1| 2| 1| 1| 1| 1| 1| 8| 1| 3| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + |
C-Cell, Adenoma | X X |
C-Cell, Adenoma, Multiple | |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + M + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + |
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | X |
Interstitial Cell, Adenoma | X X X X X |
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Mediastinal, Leukemia Mononuclear | |
Mesenteric, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 7| 5| 7| 1| 7| 3| 3| 3| 5| 3| 3| 0| 3| 8| 3| 3| 3| 6| 3| 9| 3| 3| 8| 3|
| 1| 2| 1| 7| 0| 2| 1| 1| 1| 9| 1| 1| 2| 1| 1| 1| 1| 1| 8| 1| 3| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + |
Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | |
Osteosarcoma, Metastatic, Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Oligodendroglioma Benign | X |
__________________________________________________________________________|
Spinal Cord | + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X X X X X |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Monocytic | |
Leukemia Mononuclear | X X X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 5| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 3| 1| 3| 0| 4| 3| 3| 9| 3| 9| 9| 3| 3| 3| 3| 0| 2| 3| 2| 3| 9| 3| 3| |
| 1| 1| 1| 7| 1| 9| 4| 1| 1| 9| 1| 3| 8| 1| 1| 5| 1| 1| 0| 0| 3| 1| 9| 0| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + +| 24 |
__________________________________________________________________________|____________|
Intestine Large | + A + + + + + A + + + + +| 23 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + M + A + + + A + + + + +| 22 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + A + + + + +| 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + A + + + + +| 20 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A + + + A + + + + +| 19 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + A + + + + +| 20 |
__________________________________________________________________________|____________|
Liver | + + + + A + + + + + + + + + + + + +| 33 |
Leukemia Monocytic | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X| 19 |
Neoplastic Nodule | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 5 |
Sarcoma | X | 1 |
Schwannoma NOS | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + + + +| 23 |
Leukemia Mononuclear | X X X| 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + +| 24 |
Leukemia Mononuclear | X X| 4 |
__________________________________________________________________________|____________|
Stomach | + A + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + + + + + + +| 26 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + + + + +| 25 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + +| 24 |
Leukemia Mononuclear | X| 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + A + + + + + + + + + + +| 26 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + A + + + + + + + + + + +| 23 |
Leukemia Mononuclear | X X| 4 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + A + + + + + + + + + + +| 25 |
Leukemia Mononuclear | X| 3 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 5| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 3| 1| 3| 0| 4| 3| 3| 9| 3| 9| 9| 3| 3| 3| 3| 0| 2| 3| 2| 3| 9| 3| 3| |
| 1| 1| 1| 7| 1| 9| 4| 1| 1| 9| 1| 3| 8| 1| 1| 5| 1| 1| 0| 0| 3| 1| 9| 0| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Benign, Multiple | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + +| 24 |
Adenoma | X | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + M + M + + + + +| 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + +| 36 |
Leukemia Mononuclear | X X| 6 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X| 29 |
Pars Distalis, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + + + + +| 24 |
C-Cell, Adenoma | | 2 |
C-Cell, Adenoma, Multiple | X | 1 |
C-Cell, Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + +| 27 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + M + + + + + + + + + + +| 25 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + +| 25 |
Leukemia Mononuclear | X| 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + +| 24 |
Leukemia Mononuclear | X| 1 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X| 3 |
Mesothelioma Malignant | X | 2 |
Interstitial Cell, Adenoma | X X X X X | 10 |
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X | 22 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + A + + + + + + + + + + +| 23 |
Leukemia Mononuclear | X X X X X X X| 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + +| 28 |
Mediastinal, Leukemia Mononuclear | X X | 2 |
Mesenteric, Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 5| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 3| 1| 3| 0| 4| 3| 3| 9| 3| 9| 9| 3| 3| 3| 3| 0| 2| 3| 2| 3| 9| 3| 3| |
| 1| 1| 1| 7| 1| 9| 4| 1| 1| 9| 1| 3| 8| 1| 1| 5| 1| 1| 0| 0| 3| 1| 9| 0| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + + + + + + +| 22 |
Leukemia Mononuclear | X X X X X X| 9 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M +| 24 |
Leukemia Mononuclear | X X X X X X| 10 |
__________________________________________________________________________|____________|
Spleen | + + + + A + + + + + + + + + + + + + +| 32 |
Leukemia Mononuclear | X X X X X X X X X X X X X| 21 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Thymus | + M + + + + M + + + + + +| 22 |
Leukemia Mononuclear | X| 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + M + + + +| 20 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + +| 26 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + +| 24 |
Osteosarcoma | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Osteosarcoma, Metastatic, Bone | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + +| 24 |
Leukemia Mononuclear | | 2 |
Oligodendroglioma Benign | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + +| 24 |
__________________________________________________________________________|____________|
Lung | + A + + + + + + + + + + + + +| 29 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X X X| 13 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + +| 24 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 5| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 3| 1| 3| 0| 4| 3| 3| 9| 3| 9| 9| 3| 3| 3| 3| 0| 2| 3| 2| 3| 9| 3| 3| |
| 1| 1| 1| 7| 1| 9| 4| 1| 1| 9| 1| 3| 8| 1| 1| 5| 1| 1| 0| 0| 3| 1| 9| 0| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + A + + + + + + + + + + + +| 26 |
Leukemia Mononuclear | X| 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + + +| 22 |
Leukemia Mononuclear | X| 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Monocytic | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X| 21 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6| 3| 0| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|
| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 6| 0| 3| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + I M + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + A + + + + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + I + + + + A|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + + + + + + A|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X X X X X |
Pheochromocytoma Benign, Multiple | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6| 3| 0| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|
| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 6| 0| 3| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + M + + M + + M M M + + M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + I + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
C-Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + M + + + M + + + + + + + + + + + M + + M M + A|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
Adenoma | |
Carcinoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + A|
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
Interstitial Cell, Adenoma | X X X X X|
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + M + + + + + M M + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + M + M + + M + + + + M + M + + + A|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + + + + M + M + + + + M|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6| 3| 0| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|
| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 6| 0| 3| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Keratoacanthoma | |
Lipoma | |
Papilloma | |
Sarcoma | |
Trichoepithelioma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Cerebrum, Astrocytoma NOS | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + M + + + + + + A|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + A|
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Preputial | |
Gland | |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Neurofibroma | X |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X X |
Pelvis, Transitional Epithelium, | |
Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6| 3| 0| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|
| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 6| 0| 3| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 6| 7| 7| 6| |
DAY ON TEST | 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 1| 3| 1| 3| 3| 4| 0| 3| 7| 9| 3| 5| 3| 3| 3| |
| 1| 0| 0| 0| 0| 4| 0| 0| 0| 0| 7| 0| 8| 0| 0| 4| 7| 0| 2| 5| 7| 0| 0| 0| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + A + + +| 46 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + + + + M + + + + + + + + + + +| 45 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + A + A + + +| 44 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + A + A + + +| 45 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X X | 21 |
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + I + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X X X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 6| 7| 7| 6| |
DAY ON TEST | 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 1| 3| 1| 3| 3| 4| 0| 3| 7| 9| 3| 5| 3| 3| 3| |
| 1| 0| 0| 0| 0| 4| 0| 0| 0| 0| 7| 0| 8| 0| 0| 4| 7| 0| 2| 5| 7| 0| 0| 0| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | X X X X X X | 14 |
Pheochromocytoma Benign, Multiple | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + + M + + M + M + + M + +| 37 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X | 5 |
Pars Distalis, Adenoma | X X X X X X X X X X | 25 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Adenoma | X X | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | M + M + + M + + + + M + + + + + M + + + + + + + +| 39 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X X| 2 |
Carcinoma | X X | 2 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X | 1 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 2 |
Mesothelioma Malignant | X | 2 |
Interstitial Cell, Adenoma | X X X | 8 |
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X X X X| 34 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X | 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + M + + + + + + + + + + + M + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 6| 7| 7| 6| |
DAY ON TEST | 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 1| 3| 1| 3| 3| 4| 0| 3| 7| 9| 3| 5| 3| 3| 3| |
| 1| 0| 0| 0| 0| 4| 0| 0| 0| 0| 7| 0| 8| 0| 0| 4| 7| 0| 2| 5| 7| 0| 0| 0| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X X | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| 42 |
Leukemia Mononuclear | X X X X X | 11 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X X | 21 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + M + + + + + + + M + M M M + +| 41 |
Fibroadenoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibroma | X | 1 |
Keratoacanthoma | X | 1 |
Lipoma | X | 1 |
Papilloma | X X | 2 |
Sarcoma | X | 1 |
Trichoepithelioma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 4 |
Cerebrum, Astrocytoma NOS | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Carcinoma, Metastatic, Preputial | | |
Gland | X | 1 |
Leukemia Mononuclear | X X X X X X X X | 15 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05095-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 6| 7| 7| 6| |
DAY ON TEST | 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 1| 3| 1| 3| 3| 4| 0| 3| 7| 9| 3| 5| 3| 3| 3| |
| 1| 0| 0| 0| 0| 4| 0| 0| 0| 0| 7| 0| 8| 0| 0| 4| 7| 0| 2| 5| 7| 0| 0| 0| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Neurofibroma | | 1 |
__________________________________________________________________________|____________|
Eye | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X | 6 |
Pelvis, Transitional Epithelium, | | |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X | 22 |
Mesothelioma Malignant | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
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