TR 380 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
EPINEPHRINE HCL
NTP Experiment-Test: 05095-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
Facility: Battelle Northwest
Chemical CAS #: 55-31-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1.5MG/M3 5.0MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 14 16 14
Dead 4 5 6
Survivors
Terminal Sacrifice 32 29 30
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Ileum (45) (18) (44)
Adenocarcinoma 1 (2%)
Liver (50) (31) (47)
Neoplastic Nodule 1 (2%) 1 (2%)
Neoplastic Nodule, Multiple 1 (2%)
Mesentery (1) (2)
Hemangioma 1 (100%)
Pancreas (49) (21) (47)
Salivary Glands (50) (21) (48)
Stomach, Forestomach (50) (21) (48)
Stomach, Glandular (49) (21) (47)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (21) (49)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (23) (47)
Adenoma 1 (2%)
Adrenal Gland, Medulla (50) (22) (47)
Pheochromocytoma Benign 1 (2%) 1 (5%) 4 (9%)
Islets, Pancreatic (49) (22) (47)
Adenoma 1 (2%)
Adenoma, Multiple 1 (5%)
Pituitary Gland (49) (38) (47)
Pars Distalis, Adenoma 30 (61%) 25 (66%) 32 (68%)
Pars Distalis, Carcinoma 1 (2%) 1 (3%) 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (21) (47)
C-Cell, Adenoma 4 (8%) 3 (14%) 4 (9%)
Page 2
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1.5MG/M3 5.0MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (21) (47)
Adenoma 5 (10%) 1 (5%)
Carcinoma 2 (4%) 1 (5%)
Ovary (50) (22) (47)
Granulosa Cell Tumor NOS 1 (5%)
Granulosa Cell Tumor Malignant 2 (4%)
Uterus (50) (25) (48)
Carcinoma 1 (2%)
Leiomyoma 1 (4%)
Endometrium, Deciduoma Malignant 1 (2%)
Endometrium, Polyp 1 (2%)
Endometrium, Polyp Stromal 8 (16%) 4 (16%) 4 (8%)
Endometrium, Polyp Stromal, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (21) (47)
Lymph Node (48) (22) (48)
Lymph Node, Bronchial (37) (18) (39)
Lymph Node, Mandibular (48) (17) (45)
Spleen (50) (26) (47)
Thymus (50) (19) (47)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (28) (49)
Adenocarcinoma 2 (4%) 3 (11%) 4 (8%)
Fibroadenoma 9 (18%) 11 (39%) 9 (18%)
Fibroadenoma, Multiple 1 (2%) 2 (4%)
Skin (48) (22) (48)
Fibroma 1 (2%) 1 (5%) 1 (2%)
Fibrous Histiocytoma 1 (5%)
Squamous Cell Carcinoma 1 (2%)
Page 3
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1.5MG/M3 5.0MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (21) (48)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (21) (49)
Carcinoma, Metastatic, Pituitary Gland 1 (5%)
Glioma NOS, Marked 1 (5%)
Glioma NOS, Moderate 1 (2%)
Oligodendroglioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (23) (48)
Alveolar/Bronchiolar Adenoma 1 (4%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Bronchus, Carcinoma 1 (2%)
Nose (50) (50) (46)
Respiratory Epithelium, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (23) (48)
Urinary Bladder (49) (21) (47)
Papilloma 2 (4%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 24 (48%) 18 (36%) 16 (32%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 1.5MG/M3 5.0MG/M3
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 41 43
Total Primary Neoplasms 105 76 87
Total Animals with Benign Neoplasms 43 35 38
Total Benign Neoplasms 70 49 59
Total Animals with Malignant Neoplasms 29 22 23
Total Malignant Neoplasms 35 25 27
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 1 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 2 1
Total Uncertain Neoplasms 2 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1.5MG/M3 5.0MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 17 17 13
Dead 6 5
Survivors
Terminal Sacrifice 33 26 32
Moribund 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (48) (24) (49)
Intestine Large, Cecum (49) (22) (46)
Intestine Large, Colon (50) (20) (47)
Intestine Large, Rectum (50) (20) (45)
Intestine Small, Duodenum (50) (21) (47)
Intestine Small, Ileum (49) (19) (44)
Intestine Small, Jejunum (50) (20) (45)
Liver (50) (33) (49)
Neoplastic Nodule 1 (2%) 1 (3%)
Mesentery (5) (5) (2)
Sarcoma 1 (20%)
Schwannoma NOS 1 (20%)
Pancreas (50) (23) (49)
Salivary Glands (50) (24) (49)
Stomach, Forestomach (49) (26) (48)
Sarcoma 1 (2%)
Stomach, Glandular (50) (25) (48)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (24) (50)
Schwannoma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1.5MG/M3 5.0MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (23) (49)
Osteosarcoma, Metastatic, Bone 1 (4%)
Adrenal Gland, Medulla (50) (25) (48)
Pheochromocytoma Malignant 1 (4%) 1 (2%)
Pheochromocytoma Benign 9 (18%) 2 (8%) 14 (29%)
Pheochromocytoma Benign, Multiple 2 (4%) 1 (4%) 2 (4%)
Islets, Pancreatic (50) (24) (49)
Adenoma 5 (10%) 1 (4%) 1 (2%)
Carcinoma 1 (2%) 1 (4%)
Parathyroid Gland (43) (19) (37)
Pituitary Gland (50) (36) (48)
Pars Distalis, Adenoma 34 (68%) 29 (81%) 25 (52%)
Pars Distalis, Carcinoma 1 (3%)
Thyroid Gland (50) (24) (49)
C-Cell, Adenoma 7 (14%) 2 (8%) 5 (10%)
C-Cell, Adenoma, Multiple 2 (4%) 1 (4%)
C-Cell, Carcinoma 4 (8%) 2 (8%)
Follicular Cell, Carcinoma 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (46) (27) (39)
Preputial Gland (49) (25) (49)
Adenoma 3 (6%) 2 (4%)
Carcinoma 1 (4%) 2 (4%)
Prostate (50) (25) (49)
Adenoma 1 (2%)
Seminal Vesicle (50) (24) (49)
Testes (50) (47) (50)
Interstitial Cell, Adenoma 14 (28%) 10 (21%) 8 (16%)
Interstitial Cell, Adenoma, Multiple 25 (50%) 22 (47%) 34 (68%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (23) (49)
Lymph Node (50) (28) (50)
Lymph Node, Bronchial (44) (22) (45)
Lymph Node, Mandibular (48) (24) (42)
Spleen (50) (32) (49)
Page 7
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1.5MG/M3 5.0MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Osteosarcoma, Metastatic, Bone 1 (3%)
Thymus (46) (22) (49)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (35) (20) (41)
Fibroadenoma 2 (6%) 1 (2%)
Skin (50) (26) (50)
Fibroma 5 (10%) 1 (2%)
Keratoacanthoma 2 (4%) 1 (2%)
Lipoma 1 (2%)
Papilloma 2 (4%)
Sarcoma 1 (2%)
Trichoepithelioma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (24) (50)
Osteosarcoma 1 (4%)
Skeletal Muscle (2) (1) (1)
Osteosarcoma, Metastatic, Bone 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (24) (50)
Oligodendroglioma Benign 1 (2%) 1 (4%)
Cerebrum, Astrocytoma NOS 1 (2%)
Spinal Cord (1)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (29) (49)
Alveolar/Bronchiolar Adenoma 4 (8%) 1 (3%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Preputial Gland 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (3%)
Nose (50) (49) (50)
Adenoma 1 (2%)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1.5MG/M3 5.0MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1)
Neurofibroma 1 (100%)
Eye (4) (3) (3)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (26) (49)
Pelvis, Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (50) (22) (49)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Monocytic 1 (2%)
Leukemia Mononuclear 19 (38%) 21 (42%) 22 (44%)
Mesothelioma Malignant 1 (2%) 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05095-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC EPINEPHRINE HCL Date: 09/12/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 23:29:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 1.5MG/M3 5.0MG/M3
MALE MALE MALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 49 50
Total Primary Neoplasms 150 104 133
Total Animals with Benign Neoplasms 50 47 50
Total Benign Neoplasms 119 71 102
Total Animals with Malignant Neoplasms 25 27 26
Total Malignant Neoplasms 30 32 30
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 4 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1 1
Total Uncertain Neoplasms 1 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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