TR 380 Rat Pathology Tables
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
Facility: Battelle Northwest
Chemical CAS #: 55-31-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 6| 7| 6| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 7| 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 2| 7|
| 9| 9| 1| 9| 6| 9| 0| 2| 9| 9| 9| 9| 9| 9| 8| 7| 9| 4| 9| 9| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + M + + + + + + + + + M + + A + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + A + + + + + M +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 2 2 2 2 3 1 2 3 2 2 |
Clear Cell Focus | X |
Developmental Malformation | X |
Eosinophilic Focus | X X |
Inflammation, Granulomatous | 2 2 1 2 2 2 2 4 2 2 3 |
Necrosis | 3 3 3 4 |
Bile Duct, Hyperplasia | 4 1 2 2 1 |
Hepatocyte, Cytomegaly | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 3 2 3 3 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
Acinus, Atrophy | 2 3 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Karyomegaly | 1 |
Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Suppurative | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +|
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 3 2 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 6| 7| 6| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 7| 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 2| 7|
| 9| 9| 1| 9| 6| 9| 0| 2| 9| 9| 9| 9| 9| 9| 8| 7| 9| 4| 9| 9| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Myocardium, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 |
Vacuolization Cytoplasmic | 3 2 1 2 4 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hyperplasia | 1 2 2 1 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + M + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 2 2 2 2 2 2 1 2 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia | 2 3 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | |
Dilatation | 2 2 3 |
Hemorrhage | |
Inflammation, Suppurative | |
Metaplasia, Squamous | |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + M + + + + + M M M + M M M + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 6| 7| 6| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 7| 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 2| 7|
| 9| 9| 1| 9| 6| 9| 0| 2| 9| 9| 9| 9| 9| 9| 8| 7| 9| 4| 9| 9| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X 3 3 3 4 3 |
Congestion | 3 |
Hemorrhage | 3 3 4 |
Ventricle, Dilatation | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 2 1 2 2 2 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 4 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 |
Alveolus, Inflammation, Suppurative | 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Suppurative | 2 |
Parasite Metazoan | |
Glands, Dilatation | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Acanthosis | 4 |
Inflammation, Granulomatous | 4 |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 2| 6| 7| 6| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 7| 2| 7| 2| 7| 8| 2| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 2| 7|
| 9| 9| 1| 9| 6| 9| 0| 2| 9| 9| 9| 9| 9| 9| 8| 7| 9| 4| 9| 9| 9| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Atrophy | |
Lens, Cataract | 2 2 |
__________________________________________________________________________|
Lacrimal Gland | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Infarct | |
Mineralization | 2 |
Nephropathy, Chronic | 2 3 3 2 1 4 2 2 2 3 4 3 2 3 2 2 2 3 3 3 2 1 3 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 2| 2| 1| 4| 9| 2| 2| 2| 2| 5| 2| 2| 7| 2| 7| 2| 2| 2| 8| 2| 1| 1| |
| 3| 9| 9| 9| 9| 4| 4| 3| 9| 9| 9| 9| 1| 9| 9| 7| 9| 1| 9| 9| 9| 2| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + A + + + + + + +| 45 |
Parasite Metazoan | 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + A + + + + + + +| 45 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + A + + + + + + +| 48 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.0|
Basophilic Focus | 2 2 2 2 3 3 2 2 2 2 2 | 21 2.1|
Clear Cell Focus | 1 2 | 3 1.5|
Developmental Malformation | X | 2 |
Eosinophilic Focus | 2 | 3 2.0|
Inflammation, Granulomatous | 3 3 2 2 2 3 2 2 | 19 2.3|
Necrosis | 4 3 3 | 7 3.3|
Bile Duct, Hyperplasia | 1 2 2 2 2 | 10 1.9|
Hepatocyte, Cytomegaly | | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 3 2 2 2 3 4| 11 2.6|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 2 1 3 | 7 2.1|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 2.0|
Karyomegaly | | 1 1.0|
Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 4| 1 4.0|
Inflammation, Suppurative | 3 4| 2 3.5|
Ulcer | 2 4| 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 2| 2| 1| 4| 9| 2| 2| 2| 2| 5| 2| 2| 7| 2| 7| 2| 2| 2| 8| 2| 1| 1| |
| 3| 9| 9| 9| 9| 4| 4| 3| 9| 9| 9| 9| 1| 9| 9| 7| 9| 1| 9| 9| 9| 2| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 2 2 2 2 | 13 2.0|
Thrombosis | X X | 2 |
Myocardium, Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 3 2 2 | 13 2.1|
Vacuolization Cytoplasmic | 2 1 2 3 2 2 2 2 2 1 2 4 2 | 21 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 2.0|
Hyperplasia | 2 2 3 | 7 1.9|
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + M + + + + M + + + M + M + + M| 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 2 | 3 2.7|
Pars Distalis, Hyperplasia | 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 3 3 4 2 4 2 2 1 | 17 2.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | X | 2 |
Hyperplasia | 2 3 2 | 5 2.4|
Inflammation, Suppurative | 4 2 2 4 | 5 3.2|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X | 7 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Decidual Reaction | X | 1 |
Dilatation | | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 2| 2| 1| 4| 9| 2| 2| 2| 2| 5| 2| 2| 7| 2| 7| 2| 2| 2| 8| 2| 1| 1| |
| 3| 9| 9| 9| 9| 4| 4| 3| 9| 9| 9| 9| 1| 9| 9| 7| 9| 1| 9| 9| 9| 2| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hemorrhage | 4 | 1 4.0|
Inflammation, Suppurative | 4 | 1 4.0|
Metaplasia, Squamous | 3 | 1 3.0|
Endometrium, Hyperplasia | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + M + + + + + + + + M + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + M + + + + + + M M + + + + + M + + + + + + +| 37 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + M + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 4 3 | 3 3.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Galactocele | | 1 |
__________________________________________________________________________|____________|
Skin | + M + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Acanthosis | 4| 1 4.0|
Inflammation, Chronic | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 3 2 4 | 10 3.0|
Congestion | | 1 3.0|
Hemorrhage | 3 3 2 | 6 3.0|
Ventricle, Dilatation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 2 2 2 | 12 1.9|
Epithelium, Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 2| 2| 1| 4| 9| 2| 2| 2| 2| 5| 2| 2| 7| 2| 7| 2| 2| 2| 8| 2| 1| 1| |
| 3| 9| 9| 9| 9| 4| 4| 3| 9| 9| 9| 9| 1| 9| 9| 7| 9| 1| 9| 9| 9| 2| 9| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 3 2 | 5 2.2|
Alveolus, Inflammation, Suppurative | | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Parasite Metazoan | 2 | 1 2.0|
Glands, Dilatation | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Acanthosis | | 1 4.0|
Inflammation, Granulomatous | | 1 4.0|
__________________________________________________________________________|____________|
Eye | + + + | 5 |
Atrophy | 4 | 1 4.0|
Lens, Cataract | 2 | 3 2.0|
__________________________________________________________________________|____________|
Lacrimal Gland | + + + | 3 |
Inflammation, Chronic | 3 3 2 | 3 2.7|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Infarct | 4 | 1 4.0|
Mineralization | | 1 2.0|
Nephropathy, Chronic | 2 2 2 3 2 3 3 2 2 3 2 2 2 3 3 1 3 2 2 2 2 1 3 3 2| 49 2.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 2| 3| 7| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 2| 3| 3| 8|
| 1| 1| 1| 1| 1| 7| 4| 1| 9| 1| 7| 1| 1| 1| 7| 4| 1| 1| 1| 1| 1| 3| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X 3 2 |
Basophilic Focus, Multiple | 3 |
Clear Cell Focus | 1 |
Developmental Malformation | X X X X X X |
Eosinophilic Focus | 3 |
Hyperplasia, Focal | 3 |
Inflammation, Granulomatous | 3 2 3 |
Necrosis | |
Bile Duct, Hyperplasia | 2 2 2 2 1 2|
Hepatocyte, Vacuolization Cytoplasmic| 2 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
Acinus, Atrophy | 2 2 4|
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + +|
Acanthosis | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + +|
Cardiomyopathy | 2 2 2 |
Mineralization | |
Artery, Mineralization | |
Myocardium, Necrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + +|
Hemorrhage | 4|
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 2| 3| 7| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 2| 3| 3| 8|
| 1| 1| 1| 1| 1| 7| 4| 1| 9| 1| 7| 1| 1| 1| 7| 4| 1| 1| 1| 1| 1| 3| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Vacuolization Cytoplasmic | 3 3 2 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 3 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + M|
Hyperplasia | 3 4 |
Inflammation, Suppurative | 4 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + +|
Dilatation | 3 |
Hemorrhage | |
Inflammation, Suppurative | 4 |
Prolapse | 4 |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Mediastinal, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + + + M +|
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + +|
Developmental Malformation | X |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 2| 3| 7| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 2| 3| 3| 8|
| 1| 1| 1| 1| 1| 7| 4| 1| 9| 1| 7| 1| 1| 1| 7| 4| 1| 1| 1| 1| 1| 3| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + +|
Galactocele | X |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Diaphragm, Developmental Malformation| X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
Compression | 3 3 |
Ventricle, Dilatation | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + +|
Foreign Body | |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 3 |
Mineralization | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + +|
Foreign Body | 4 |
Mineralization | |
Alveolus, Edema | 4 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2 2 4 2 |
Alveolus, Inflammation, Suppurative | 4 |
Bronchiole, Inflammation, Suppurative| 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Foreign Body | 2 2 2 |
Inflammation, Suppurative | 1 3 4 3 3 1 |
Glands, Dilatation | 1 4 1 2 2 1 1 1 2|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Respiratory Epithelium, Hyperplasia | 2 2 1 2 1 1 3|
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + +|
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 2| 3| 7| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 2| 3| 3| 8|
| 1| 1| 1| 1| 1| 7| 4| 1| 9| 1| 7| 1| 1| 1| 7| 4| 1| 1| 1| 1| 1| 3| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + +|
Lens, Cataract | 2 2 2 2|
__________________________________________________________________________|
Lacrimal Gland | + |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + +|
Mineralization | |
Nephropathy, Chronic | 4 1 2 4 1 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 1| 5| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| |
DAY ON TEST | 5| 3| 2| 3| 3| 2| 2| 3| 1| 5| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 5| 2| 5| |
| 3| 1| 8| 1| 1| 0| 6| 5| 4| 3| 0| 1| 1| 1| 1| 9| 1| 1| 1| 4| 1| 1| 3| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Intestine Large | + + + A + + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + M + + + M + + + + A| 17 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Intestine Small | + + + A + + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + + + A| 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + + + A| 19 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + +| 31 |
Angiectasis | 4 | 1 4.0|
Basophilic Focus | 4 3 3 2 3 3 | 9 2.9|
Basophilic Focus, Multiple | | 1 3.0|
Clear Cell Focus | 4 | 2 2.5|
Developmental Malformation | X X X| 9 |
Eosinophilic Focus | | 1 3.0|
Hyperplasia, Focal | | 1 3.0|
Inflammation, Granulomatous | 3 2 2 | 6 2.5|
Necrosis | 3 2 2 | 3 2.3|
Bile Duct, Hyperplasia | 2 2 2 | 9 1.9|
Hepatocyte, Vacuolization Cytoplasmic| 3 2 4 3 | 7 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + +| 21 |
Acinus, Atrophy | 3 2 3 2 | 7 2.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + +| 21 |
Acanthosis | 2 | 1 2.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + +| 21 |
Mineralization | 4| 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + +| 21 |
Cardiomyopathy | 2 2 2 | 6 2.0|
Mineralization | 4| 1 4.0|
Artery, Mineralization | 4| 1 4.0|
Myocardium, Necrosis | 4| 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 1| 5| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| |
DAY ON TEST | 5| 3| 2| 3| 3| 2| 2| 3| 1| 5| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 5| 2| 5| |
| 3| 1| 8| 1| 1| 0| 6| 5| 4| 3| 0| 1| 1| 1| 1| 9| 1| 1| 1| 4| 1| 1| 3| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + +| 23 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + +| 23 |
Hemorrhage | | 1 4.0|
Necrosis | 4| 2 4.0|
Vacuolization Cytoplasmic | 2 4 3 2 2 | 9 2.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + + + + + + + +| 22 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + +| 22 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + +| 20 |
Hyperplasia | 3| 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +| 38 |
Cyst | X X X | 3 |
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + +| 21 |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia | 1 1 2 2 1 | 9 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + M + + +| 21 |
Hyperplasia | | 2 3.5|
Inflammation, Suppurative | 3 | 3 3.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + +| 22 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + +| 25 |
Dilatation | | 1 3.0|
Hemorrhage | 4 | 1 4.0|
Inflammation, Suppurative | 2 | 2 3.0|
Prolapse | | 1 4.0|
Endometrium, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + +| 21 |
Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + +| 22 |
Mediastinal, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 1| 5| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| |
DAY ON TEST | 5| 3| 2| 3| 3| 2| 2| 3| 1| 5| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 5| 2| 5| |
| 3| 1| 8| 1| 1| 0| 6| 5| 4| 3| 0| 1| 1| 1| 1| 9| 1| 1| 1| 4| 1| 1| 3| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + M + + + + + + + +| 18 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + M + +| 17 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + +| 26 |
Developmental Malformation | | 1 |
Fibrosis | 3 4| 2 3.5|
Hematopoietic Cell Proliferation | | 1 3.0|
Pigmentation | 4| 1 4.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + +| 19 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + +| 28 |
Galactocele | | 1 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + +| 22 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Diaphragm, Developmental Malformation| | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + +| 21 |
Compression | 3 4 4 3 | 6 3.3|
Ventricle, Dilatation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + +| 21 |
Foreign Body | 2 | 1 2.0|
Inflammation, Chronic | 2 | 2 1.5|
Inflammation, Suppurative | 3 2 1 | 4 2.3|
Mineralization | 4| 1 4.0|
Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + +| 23 |
Foreign Body | | 1 4.0|
Mineralization | 4| 1 4.0|
Alveolus, Edema | | 1 4.0|
Alveolus, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 7| 1| 5| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| |
DAY ON TEST | 5| 3| 2| 3| 3| 2| 2| 3| 1| 5| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 5| 2| 5| |
| 3| 1| 8| 1| 1| 0| 6| 5| 4| 3| 0| 1| 1| 1| 1| 9| 1| 1| 1| 4| 1| 1| 3| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Histiocyte | 3 3 | 7 2.7|
Alveolus, Inflammation, Suppurative | | 1 4.0|
Bronchiole, Inflammation, Suppurative| | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | | 1 4.0|
Foreign Body | 2 3 | 5 2.2|
Inflammation, Suppurative | 2 3 3 2 | 10 2.5|
Glands, Dilatation | 2 2 2 1 1 2| 15 1.7|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 2 1 3 2 1 | 12 1.8|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 3 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + +| 21 |
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 7 |
Lens, Cataract | 3 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + +| 23 |
Mineralization | 4| 1 4.0|
Nephropathy, Chronic | 2 2 3 2 2 2 2 3 3 3 2 4| 21 2.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + +| 21 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 3| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 3| 3| 3| 8| 3| 3| 3| 5| 3| 1| 3| 2| 3| 7| 5| 3| 4| 3| 1| 3| 3|
| 0| 0| 5| 4| 7| 0| 0| 1| 0| 0| 0| 7| 0| 5| 0| 2| 0| 2| 6| 0| 4| 0| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + A + + A + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + A + + + A + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + A + + + A + + A + + + + + +|
Parasite Metazoan | |
Artery, Inflammation | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + A + + + A + + A + + + + + +|
Hemorrhage | |
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + A + + A + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + A + + + A + + A + + + + + +|
Muscularis, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + A + + + A + + A + + + + + +|
Artery, Inflammation | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + A + + + A + + A + + + + + +|
Artery, Inflammation | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + A + + + A + + A + + + + + +|
Artery, Inflammation | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + A + + + A + + A + + + + + +|
Angiectasis | |
Basophilic Focus | 2 2 2 2 2 2 2 1 2 2 |
Clear Cell Focus | 2 2 |
Developmental Malformation | X X X X |
Eosinophilic Focus | |
Eosinophilic Focus, Multiple | X |
Hematopoietic Cell Proliferation | 3 2 |
Inflammation, Granulomatous | 2 3 3 4 3 1 3 2 2 |
Inflammation, Suppurative | 2 3 |
Mixed Cell Focus | X |
Necrosis | 2 3 |
Artery, Inflammation | 4 |
Artery, Mineralization | |
Bile Duct, Hyperplasia | 2 2 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 3 3 3 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | 4 |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + M + + + A + + M + + + + + +|
Fibrosis | 3 |
Acinus, Atrophy | 2 2 |
Artery, Inflammation | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + A + + A + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + A + + A + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + A + + A + + + + + +|
Acanthosis | 3 2 3 4 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 3| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 3| 3| 3| 8| 3| 3| 3| 5| 3| 1| 3| 2| 3| 7| 5| 3| 4| 3| 1| 3| 3|
| 0| 0| 5| 4| 7| 0| 0| 1| 0| 0| 0| 7| 0| 5| 0| 2| 0| 2| 6| 0| 4| 0| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Developmental Malformation | X |
Hyperkeratosis | 2 |
Inflammation, Suppurative | 3 2 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + A + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 2 |
Mineralization | 4 |
Artery, Inflammation | 4 |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + A + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 2 2 3 2 2 2 |
Mineralization | 4 |
Thrombosis | X 3 X |
Artery, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + A + + + A + + A + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + A + + + A + + A + + + + + +|
Angiectasis | |
Hemorrhage | 2 |
Hyperplasia | 2 |
Necrosis | 2 |
Thrombosis | |
Vacuolization Cytoplasmic | 2 2 3 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + A + + + A + + A + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + + + A + + M + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + A + + M + + M + + +|
Hyperplasia | 4 1|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + A + + A + + + + + +|
Cyst | X |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 2 2 2 |
Pars Intermedia, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + A + + + A + + M + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 4 2 1 1 1 3 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 3| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 3| 3| 3| 8| 3| 3| 3| 5| 3| 1| 3| 2| 3| 7| 5| 3| 4| 3| 1| 3| 3|
| 0| 0| 5| 4| 7| 0| 0| 1| 0| 0| 0| 7| 0| 5| 0| 2| 0| 2| 6| 0| 4| 0| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + A + + + + + M + + +|
Hyperplasia | |
Inflammation, Suppurative | |
Metaplasia, Squamous | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + A + + + M + + A + + + + + +|
Cyst | X X |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + A + + A + + + + + +|
Dilatation | 2 |
__________________________________________________________________________|
Vagina | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Neutrophilia | 4 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + A + + + A + + A + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + A + + A + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M M + + + + + + + + A + + M + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + A + + + M + + A + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + A + + + A + + A + + + + + +|
Fibrosis | 4 4 |
Hematopoietic Cell Proliferation | 3 3 4 |
Infarct | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + A + + A + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + M + + + + + + + + + + A + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + A + + A + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Diaphragm, Developmental Malformation| X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + A + + + + + + + + +|
Compression | 3 2 3 3 |
Thrombosis | |
Ventricle, Dilatation | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 5| 3| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 3| 3| 3| 8| 3| 3| 3| 5| 3| 1| 3| 2| 3| 7| 5| 3| 4| 3| 1| 3| 3|
| 0| 0| 5| 4| 7| 0| 0| 1| 0| 0| 0| 7| 0| 5| 0| 2| 0| 2| 6| 0| 4| 0| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + A + + + M + + A + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic | 3 2 2 1 |
Inflammation, Suppurative | 1 2 2 3 2 1 2 1 3 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + A + + A + + + + + +|
Foreign Body | 2 |
Inflammation, Granulomatous | 4 |
Mineralization | 4 |
Alveolar Epithelium, Hyperplasia | 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2 3 2 |
Alveolus, Inflammation, Suppurative | 2 1 2 2 |
Artery, Inflammation | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + A + + + A + + A + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 4 2|
Glands, Dilatation | 1 2 1 2 2 2 2 1 2 1 2 2 1 2 1 2 2 2 3 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Respiratory Epithelium, Hyperplasia | 2 1 2 1 2 1 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + A + + + A + + A + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 2 |
__________________________________________________________________________|
Lacrimal Gland | + |
Degeneration | 3 |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + A + + A + + + + + +|
Mineralization | 4 2 |
Nephropathy, Chronic | 3 3 2 3 3 4 2 4 2 2 4 2 3 2 3 2 2 2 2 4 3 3|
Pelvis, Dilatation | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + + A + + A + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 6| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 2| 3| 7| 2| 3| 6| 3| |
| 0| 0| 2| 2| 0| 2| 0| 0| 0| 0| 7| 0| 0| 9| 0| 0| 0| 0| 5| 0| 9| 0| 0| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + A + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + A + + + + + +| 44 |
Parasite Metazoan | 2 | 1 2.0|
Artery, Inflammation | 4 | 2 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| 45 |
Hemorrhage | 2 | 1 2.0|
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + A + + + + + + + A + + + + + +| 44 |
Muscularis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + A + + + + + +| 44 |
Artery, Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + A + + + + + +| 44 |
Artery, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + A + + + + + +| 44 |
Artery, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Angiectasis | 1 4 | 2 2.5|
Basophilic Focus | 3 2 2 1 2 2 4 1 2 2 2 2| 22 2.0|
Clear Cell Focus | 2| 3 2.0|
Developmental Malformation | X X| 6 |
Eosinophilic Focus | 3 | 1 3.0|
Eosinophilic Focus, Multiple | | 1 |
Hematopoietic Cell Proliferation | | 2 2.5|
Inflammation, Granulomatous | 2 2 3 2 1 2 2 2 2 3 3 2| 21 2.3|
Inflammation, Suppurative | | 2 2.5|
Mixed Cell Focus | | 1 |
Necrosis | 4 | 3 3.0|
Artery, Inflammation | | 1 4.0|
Artery, Mineralization | 4 | 1 4.0|
Bile Duct, Hyperplasia | 2 2 2 1 | 8 1.9|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 3 2 4 3 4 | 11 2.8|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Inflammation, Chronic | | 1 4.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Fibrosis | | 1 3.0|
Acinus, Atrophy | 3 2 2 2 2 2 2 3 2| 11 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 6| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 2| 3| 7| 2| 3| 6| 3| |
| 0| 0| 2| 2| 0| 2| 0| 0| 0| 0| 7| 0| 0| 9| 0| 0| 0| 0| 5| 0| 9| 0| 0| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Artery, Inflammation | 4 | 2 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acanthosis | | 4 3.0|
Developmental Malformation | | 1 |
Hyperkeratosis | | 1 2.0|
Inflammation, Suppurative | | 4 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +| 47 |
Inflammation, Chronic | 3 | 1 3.0|
Inflammation, Suppurative | | 1 2.0|
Mineralization | 4 | 2 4.0|
Artery, Inflammation | | 1 4.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2| 20 2.0|
Mineralization | 4 | 2 4.0|
Thrombosis | X | 4 3.0|
Artery, Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Angiectasis | 3 | 1 3.0|
Hemorrhage | 2 | 2 2.0|
Hyperplasia | 3 3 2 2 2 2 2| 8 2.3|
Necrosis | | 1 2.0|
Thrombosis | X | 1 |
Vacuolization Cytoplasmic | 3 2 2 2 3 2 3 2 3 3 3 2 | 17 2.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 2 4 1 | 4 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + M + + + M + + + + + + +| 44 |
Hyperplasia | 3 2 2 | 5 2.4|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + I + +| 47 |
Cyst | | 1 |
Pars Distalis, Angiectasis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 6| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 2| 3| 7| 2| 3| 6| 3| |
| 0| 0| 2| 2| 0| 2| 0| 0| 0| 0| 7| 0| 0| 9| 0| 0| 0| 0| 5| 0| 9| 0| 0| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia | | 3 2.0|
Pars Intermedia, Angiectasis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia | 1 4 3 | 11 2.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Suppurative | 3 4 3 4 | 4 3.5|
Metaplasia, Squamous | 4 | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst | X X X | 5 |
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + + | 2 |
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Neutrophilia | | 1 4.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + + + + + M M M + + M + + + + + M M| 39 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M + + + + + + + + + + + + + + + + + + + + + +| 45 |
Hyperplasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Fibrosis | 3 | 3 3.7|
Hematopoietic Cell Proliferation | 4 3 | 5 3.4|
Infarct | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 6| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 2| 3| 7| 2| 3| 6| 3| |
| 0| 0| 2| 2| 0| 2| 0| 0| 0| 0| 7| 0| 0| 9| 0| 0| 0| 0| 5| 0| 9| 0| 0| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Diaphragm, Developmental Malformation| | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Compression | 2 2 3 2 4 | 9 2.7|
Thrombosis | 2 | 1 2.0|
Ventricle, Dilatation | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Foreign Body | 2 2 2 2 | 5 2.0|
Inflammation, Chronic | | 4 2.0|
Inflammation, Suppurative | 2 1 2 2 2 1 2 3 | 17 1.9|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Foreign Body | | 1 2.0|
Inflammation, Granulomatous | | 1 4.0|
Mineralization | 4 | 2 4.0|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 3 | 6 2.5|
Alveolus, Inflammation, Suppurative | 3 | 5 2.0|
Artery, Inflammation | 4 | 2 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + A + + + + + +| 46 |
Foreign Body | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 2 1 1 2 | 6 2.0|
Glands, Dilatation | 2 1 2 1 2 2 2 2 3 2 2 2 2 3 2 2 1| 37 1.8|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 1 2.0|
Respiratory Epithelium, Hyperplasia | 1 1 1 2 2 2 | 13 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 6| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 3| 3| 2| 3| 7| 2| 3| 6| 3| |
| 0| 0| 2| 2| 0| 2| 0| 0| 0| 0| 7| 0| 0| 9| 0| 0| 0| 0| 5| 0| 9| 0| 0| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Lens, Cataract | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
Degeneration | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mineralization | 2 | 3 2.7|
Nephropathy, Chronic | 2 2 2 3 3 2 1 3 4 3 3 2 2 1 3 2 2 2 3 2 3 2 2 4 2| 47 2.6|
Pelvis, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 4| 6| 2| 2| 2| 5| 2| 2| 2| 2| 2| 5| 2| 2| 0| 1| 2| 2| 1| 2| 9| 1| 2|
| 9| 9| 0| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 9| 9| 7| 7| 9| 9| 7| 9| 3| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Parasite Metazoan | 2 2 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 2 1 2 1 2 |
Clear Cell Focus | 1 2 3 1 2 2 2 2 2 2 2|
Developmental Malformation | X X X |
Eosinophilic Focus | |
Fibrosis | |
Inflammation, Granulomatous | 2 2 2 2 |
Necrosis | 2 |
Thrombosis, Multiple | 2 |
Bile Duct, Fibrosis | 3 2 2 2 2 3|
Bile Duct, Hyperplasia | 2 3 2 2 1 2 2 2 2 3 2 2 2 2 2 2 2 2|
Hepatocyte, Vacuolization Cytoplasmic| 2 4 2 |
__________________________________________________________________________|
Mesentery | + + |
Fibrosis | |
Hemorrhage | |
Inflammation, Chronic | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Inflammation, Chronic | 3 |
Acinus, Atrophy | 1 1 2 2 2 3 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 |
Karyomegaly | 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + M + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | 2 |
Inflammation, Suppurative | 3 |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 4| 6| 2| 2| 2| 5| 2| 2| 2| 2| 2| 5| 2| 2| 0| 1| 2| 2| 1| 2| 9| 1| 2|
| 9| 9| 0| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 9| 9| 7| 7| 9| 9| 7| 9| 3| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3|
Cyst | X |
Erosion | 4 2 |
Fibrosis | 4|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 3 4|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 1 3 2 2 2 3 |
Thrombosis | X |
Atrium, Dilatation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3|
Mineralization | 1 |
Vacuolization Cytoplasmic | 2 2 3 3 2 2 2 2|
Vacuolization Nuclear | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 2 1 1 2 |
Necrosis | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 2 2 |
Follicular Cell, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Suppurative | 4 4 4 2 3|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 4| 6| 2| 2| 2| 5| 2| 2| 2| 2| 2| 5| 2| 2| 0| 1| 2| 2| 1| 2| 9| 1| 2|
| 9| 9| 0| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 9| 9| 7| 7| 9| 9| 7| 9| 3| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Suppurative | 1 3 2 2 3 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 4 3 4 3 2 3 2 4 4 4 4|
Mineralization | 3 |
Artery, Inflammation | 2 4 |
Interstitial Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Fibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + M + + M + + + + M + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 4 |
Infarct | 2 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M + + + + M + + M + M + + M M + + + + + + +|
Galactocele | X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Diaphragm, Developmental Malformation| X |
Diaphragm, Fibrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 1 2 4 4|
Congestion | |
Gliosis | |
Hemorrhage | 4 2 |
Ventricle, Dilatation | 4 4 3|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 5| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 4| 6| 2| 2| 2| 5| 2| 2| 2| 2| 2| 5| 2| 2| 0| 1| 2| 2| 1| 2| 9| 1| 2|
| 9| 9| 0| 3| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 9| 9| 7| 7| 9| 9| 7| 9| 3| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 |
Inflammation, Chronic | 2 2 2 |
Inflammation, Suppurative | 3 1 2 2 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Hemorrhage | 2 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Edema | |
Alveolus, Fibrosis | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 2 |
Alveolus, Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2|
Hemorrhage | 3 |
Inflammation, Suppurative | 2 3 2 2 2 |
Necrosis | 3 |
Glands, Dilatation | 1 2 1 1 2 1 1 |
Glands, Hyperplasia | 4 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 3 |
Respiratory Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 2 2 |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 4 2 2 3 4 2 3 2 2 3 3 2 2 2 3 4 1 3 3 3 4 2 2 3|
Pelvis, Hyperplasia | |
Pelvis, Inflammation, Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 9| 2| 1| 2| 2| 0| 2| 7| 2| 2| 1| 2| 0| 1| 2| |
| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 6| 9| 7| 9| 9| 2| 9| 9| 9| 9| 7| 9| 7| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + M + M + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 4 | 1 4.0|
Parasite Metazoan | 2 2 X | 5 2.0|
Artery, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 4 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 3 2 2 3 2 | 7 2.3|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 2| 2 2.5|
Basophilic Focus | 2 2 2 2 2 1 2 2 2 3 2 3| 17 1.9|
Clear Cell Focus | 3 2 2 2 2 2 2 | 18 2.0|
Developmental Malformation | X X | 5 |
Eosinophilic Focus | X| 1 |
Fibrosis | 2 | 1 2.0|
Inflammation, Granulomatous | 3 1 2 2 2 2 | 10 2.0|
Necrosis | | 1 2.0|
Thrombosis, Multiple | | 1 2.0|
Bile Duct, Fibrosis | 2 | 7 2.3|
Bile Duct, Hyperplasia | 2 2 2 2 2 1 2 2 2 2 1 2 2 2 1| 33 1.9|
Hepatocyte, Vacuolization Cytoplasmic| 3 2 | 5 2.6|
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Fibrosis | 4 | 1 4.0|
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic | 4 4 | 4 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Acinus, Atrophy | 4 3 2 3 3 2 2 3 2 3 2 3 | 19 2.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 3 1.0|
Karyomegaly | | 3 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 9| 2| 1| 2| 2| 0| 2| 7| 2| 2| 1| 2| 0| 1| 2| |
| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 6| 9| 7| 9| 9| 2| 9| 9| 9| 9| 7| 9| 7| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 4 | 2 3.5|
Hyperkeratosis | 2 | 2 2.0|
Inflammation, Suppurative | 4 3 3 3 | 5 3.2|
Ulcer | 3 | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Cyst | | 1 |
Erosion | 3 | 3 3.0|
Fibrosis | 3 | 2 3.5|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Chronic | 3 | 3 3.3|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 2 2 2 2 3 2 2 1 2 2 2 | 24 2.0|
Thrombosis | | 1 |
Atrium, Dilatation | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 1 2 2 1| 8 1.8|
Mineralization | | 1 1.0|
Vacuolization Cytoplasmic | 2 3 2 2 1 2 2 2 2 3 2 | 19 2.2|
Vacuolization Nuclear | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 3 2 2 1 | 14 1.6|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + M M M + + M + + + + + + + + +| 43 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hyperplasia | 1 | 3 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 3 2 | 9 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 9| 2| 1| 2| 2| 0| 2| 7| 2| 2| 1| 2| 0| 1| 2| |
| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 6| 9| 7| 9| 9| 2| 9| 9| 9| 9| 7| 9| 7| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + M + + + + + + + M + + + + + M + + + +| 46 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Cyst | X X | 3 |
Inflammation, Suppurative | 3 3 3 4 | 9 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.5|
Inflammation, Suppurative | 2 3 3 4 3 3 | 12 2.6|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 3 3 4 2 | 8 2.6|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 4 3 2 3 3 4 4 4 4 3 2 3 4 2 4 3 4 4 4| 35 3.3|
Mineralization | | 1 3.0|
Artery, Inflammation | 3 3 2 | 5 2.8|
Interstitial Cell, Hyperplasia | 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + M + + + + + + + + + + + + + + M + + +| 44 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 4 3 | 3 3.3|
Hematopoietic Cell Proliferation | | 1 4.0|
Infarct | 4 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + + + + M + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + M + + + + M + + + + + + + M + M M + + + + M| 35 |
Galactocele | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 9| 2| 1| 2| 2| 0| 2| 7| 2| 2| 1| 2| 0| 1| 2| |
| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 6| 9| 7| 9| 9| 2| 9| 9| 9| 9| 7| 9| 7| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Diaphragm, Developmental Malformation| | 1 |
Diaphragm, Fibrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X 2 3 3 4 | 9 2.9|
Congestion | 3 | 1 3.0|
Gliosis | 1 | 1 1.0|
Hemorrhage | 3 | 3 3.0|
Ventricle, Dilatation | 3 | 4 3.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 2 2 | 5 2.0|
Inflammation, Chronic | | 3 2.0|
Inflammation, Suppurative | 1 2 2 2 2 2 3 3 2| 14 2.1|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 2.0|
Hemorrhage | | 2 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
Alveolus, Edema | 3 | 1 3.0|
Alveolus, Fibrosis | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 1 | 6 1.8|
Alveolus, Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 2 | 4 2.0|
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | 1 3 3 | 8 2.3|
Necrosis | | 1 3.0|
Glands, Dilatation | 1 2 1 1 2 2 | 13 1.4|
Glands, Hyperplasia | | 2 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 9| 2| 1| 2| 2| 0| 2| 7| 2| 2| 1| 2| 0| 1| 2| |
| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 6| 9| 7| 9| 9| 2| 9| 9| 9| 9| 7| 9| 7| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Hyperplasia, | | |
Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 4 |
Lens, Cataract | 2 3 | 4 2.3|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 3 2 3 3 3 2 3 3 3 3 2 3 2 2 3 4 4 2 2 3 3 3 3 4 3| 49 2.8|
Pelvis, Hyperplasia | 2 | 1 2.0|
Pelvis, Inflammation, Suppurative | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Suppurative | 3 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 7| 5| 7| 1| 7| 3| 3| 3| 5| 3| 3| 0| 3| 8| 3| 3| 3| 6| 3| 9| 3| 3| 8| 3|
| 1| 2| 1| 7| 0| 2| 1| 1| 1| 9| 1| 1| 2| 1| 1| 1| 1| 1| 8| 1| 3| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + A + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + A + + + |
Hemorrhage | 1 2 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + A + + |
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + A + + |
__________________________________________________________________________|
Intestine Small | + + + A + + + + A + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + A + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + A + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + A + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + |
Basophilic Focus | 3 2 |
Clear Cell Focus | 2 |
Developmental Malformation | X X |
Inflammation, Granulomatous | 2 2 |
Necrosis | 3 4 |
Bile Duct, Hyperplasia | 2 3 3 2 2 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 4 3 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | |
Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + |
Acinus, Atrophy | 2 2 2 3 2 3 |
Artery, Inflammation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + |
Hemorrhage | 4 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + |
Acanthosis | 2 3 |
Diverticulum | 2 |
Fibrosis | 3 |
Inflammation, Suppurative | 4 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + |
Inflammation, Suppurative | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 7| 5| 7| 1| 7| 3| 3| 3| 5| 3| 3| 0| 3| 8| 3| 3| 3| 6| 3| 9| 3| 3| 8| 3|
| 1| 2| 1| 7| 0| 2| 1| 1| 1| 9| 1| 1| 2| 1| 1| 1| 1| 1| 8| 1| 3| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + |
Vacuolization Cytoplasmic | 2 2 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M M + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + |
Cyst | X |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + |
C-Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + |
Angiectasis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + |
Cyst | X |
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + M + + + + + + + |
Inflammation, Suppurative | 2 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 3 4 4 4 4|
Artery, Inflammation | 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Renal, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + |
Fibrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + |
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 7| 5| 7| 1| 7| 3| 3| 3| 5| 3| 3| 0| 3| 8| 3| 3| 3| 6| 3| 9| 3| 3| 8| 3|
| 1| 2| 1| 7| 0| 2| 1| 1| 1| 9| 1| 1| 2| 1| 1| 1| 1| 1| 8| 1| 3| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + |
Compression | 3 3 4 3 3 |
Hemorrhage | 3 3 2 |
Ventricle, Dilatation | 4 |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + |
Hemorrhage | 2 |
Inflammation, Suppurative | 2 2 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + |
Hemorrhage | 2 |
Alveolar Epithelium, Hyperplasia | 3 2 3 |
Alveolus, Edema | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
Alveolus, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 2 |
Inflammation, Suppurative | 2 3 |
Glands, Dilatation | 2 2 1 1 2 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Respiratory Epithelium, Hyperplasia | 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + |
Inflammation, Chronic | 3 |
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
Cataract | 2 |
Lens, Cataract | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 7| 5| 7| 1| 7| 3| 3| 3| 5| 3| 3| 0| 3| 8| 3| 3| 3| 6| 3| 9| 3| 3| 8| 3|
| 1| 2| 1| 7| 0| 2| 1| 1| 1| 9| 1| 1| 2| 1| 1| 1| 1| 1| 8| 1| 3| 1| 1| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.5MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + |
Infarct | 4 |
Nephropathy, Chronic | 4 2 3 3 1 4 2 4 3 3 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 5| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 3| 1| 3| 0| 4| 3| 3| 9| 3| 9| 9| 3| 3| 3| 3| 0| 2| 3| 2| 3| 9| 3| 3| |
| 1| 1| 1| 7| 1| 9| 4| 1| 1| 9| 1| 3| 8| 1| 1| 5| 1| 1| 0| 0| 3| 1| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + +| 24 |
__________________________________________________________________________|____________|
Intestine Large | + A + + + + + A + + + + +| 23 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + M + A + + + A + + + + +| 22 |
Hemorrhage | | 3 2.3|
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + A + + + + +| 20 |
Parasite Metazoan | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + A + + + + +| 20 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A + + + A + + + + +| 19 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + A + + + + +| 20 |
__________________________________________________________________________|____________|
Liver | + + + + A + + + + + + + + + + + + +| 33 |
Basophilic Focus | 2 3 2 | 5 2.4|
Clear Cell Focus | | 1 2.0|
Developmental Malformation | X X | 4 |
Inflammation, Granulomatous | 2 | 3 2.0|
Necrosis | 2 2 3 | 5 2.8|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 3| 14 2.2|
Hepatocyte, Vacuolization Cytoplasmic| 2 4 | 5 3.2|
__________________________________________________________________________|____________|
Mesentery | + + + + | 5 |
Inflammation, Chronic | 3 3 | 2 3.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + + + +| 23 |
Acinus, Atrophy | 3 2 2 2 2 | 11 2.3|
Artery, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + +| 24 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Stomach | + A + + + + + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + + + + + + +| 26 |
Acanthosis | 3 | 3 2.7|
Diverticulum | | 1 2.0|
Fibrosis | | 1 3.0|
Inflammation, Suppurative | 3 | 2 3.5|
Ulcer | 2 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + + + + +| 25 |
Inflammation, Suppurative | 3 3 | 2 3.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 5| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 3| 1| 3| 0| 4| 3| 3| 9| 3| 9| 9| 3| 3| 3| 3| 0| 2| 3| 2| 3| 9| 3| 3| |
| 1| 1| 1| 7| 1| 9| 4| 1| 1| 9| 1| 3| 8| 1| 1| 5| 1| 1| 0| 0| 3| 1| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + +| 24 |
Cardiomyopathy | 2 2 1 2 | 7 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + A + + + + + + + + + + +| 26 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + A + + + + + + + + + + +| 23 |
Vacuolization Cytoplasmic | 3 3 2 3 | 8 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + A + + + + + + + + + + +| 25 |
Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + +| 24 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + M + M + + + + +| 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + +| 36 |
Cyst | X | 2 |
Pars Distalis, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + + + + +| 24 |
C-Cell, Hyperplasia | 3 4 | 3 3.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + +| 27 |
Angiectasis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + M + + + + + + + + + + +| 25 |
Cyst | X | 2 |
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + +| 25 |
Inflammation, Suppurative | 4 3 2 3 | 6 2.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + +| 24 |
Inflammation, Suppurative | 3 2 | 3 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Atrophy | 4 2 4 3 4 3 3 3 4 4 3 4 3 4 4 3 | 23 3.5|
Artery, Inflammation | | 2 3.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + A + + + + + + + + + + +| 23 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + +| 28 |
Renal, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + + + + + + +| 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 5| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 3| 1| 3| 0| 4| 3| 3| 9| 3| 9| 9| 3| 3| 3| 3| 0| 2| 3| 2| 3| 9| 3| 3| |
| 1| 1| 1| 7| 1| 9| 4| 1| 1| 9| 1| 3| 8| 1| 1| 5| 1| 1| 0| 0| 3| 1| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + M +| 24 |
__________________________________________________________________________|____________|
Spleen | + + + + A + + + + + + + + + + + + + +| 32 |
Fibrosis | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + M + + + + + +| 22 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + M + + + +| 20 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + +| 26 |
Cyst Epithelial Inclusion | X X | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + +| 24 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + +| 24 |
Compression | 3 3 3 2 2 2 | 11 2.8|
Hemorrhage | 2 3 3| 6 2.7|
Ventricle, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + +| 24 |
Hemorrhage | | 1 2.0|
Inflammation, Suppurative | 2 2 3 | 6 2.2|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + A + + + + + + + + + + + + +| 29 |
Hemorrhage | 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia | 4 | 4 3.0|
Alveolus, Edema | | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 4| 4 2.8|
Alveolus, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 2 2 2 | 5 2.0|
Inflammation, Suppurative | 3 2 2 3 4 3 3 | 9 2.8|
Glands, Dilatation | 1 2 1 2 2 2 2 2 2 1 1 | 19 1.7|
Nasolacrimal Duct, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| 5| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 6| |
DAY ON TEST | 3| 3| 3| 1| 3| 0| 4| 3| 3| 9| 3| 9| 9| 3| 3| 3| 3| 0| 2| 3| 2| 3| 9| 3| 3| |
| 1| 1| 1| 7| 1| 9| 4| 1| 1| 9| 1| 3| 8| 1| 1| 5| 1| 1| 0| 0| 3| 1| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
1.5MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Suppurative | 3 | 1 3.0|
Respiratory Epithelium, Hyperplasia | 1 2 3 | 5 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + +| 24 |
Inflammation, Chronic | | 1 3.0|
Epithelium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 3 |
Cataract | | 1 2.0|
Lens, Cataract | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + A + + + + + + + + + + + +| 26 |
Infarct | | 1 4.0|
Nephropathy, Chronic | 2 4 3 4 2 2 2 2 4 3 3 4 4 2| 26 2.9|
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + + +| 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6| 3| 0| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|
| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 6| 0| 3| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + A|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + I M + + + + + + + + + + + + + + + + + + M|
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + A + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + A|
Angiectasis, Focal | 3 |
Basophilic Focus | 2 1 3 2 2 3 3 2 1 1 |
Clear Cell Focus | 2 2 2 |
Developmental Malformation | X |
Inflammation, Granulomatous | 2 2 2 |
Inflammation, Suppurative | |
Necrosis | 3 3 |
Bile Duct, Fibrosis | 2 1 |
Bile Duct, Hyperplasia | 2 2 2 3 2 1 3 3 1 3 3 3 2 1 3 1 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 3 2 2 3 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Chronic | 2 |
Acinus, Atrophy | 2 3 1 2 1 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Chronic | 2 2 |
Karyomegaly | 1 1 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Acanthosis | |
Hyperkeratosis | |
Inflammation, Suppurative | 3 |
Ulcer | |
Muscularis, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + I + + + + A|
Fibrosis | 3 3 |
Inflammation, Chronic | 3 3 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6| 3| 0| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|
| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 6| 0| 3| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 3 2 2 2 2 2 3 2 2 2|
Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + A|
Developmental Malformation | X |
Hemorrhage | 3 |
Hyperplasia | 1 2 2 |
Vacuolization Cytoplasmic | 3 3 2 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + + + + + + A|
Hyperplasia, Focal | 2 |
Hyperplasia | 3 2 2 2 2 2 2 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + M + + M + + M M M + + M + + M|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + I + + + + + + + + + + + + + + + + + + A|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + M + + + M + + + + + + + + + + + M + + M M + A|
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
Cyst | |
Inflammation, Suppurative | 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Suppurative | 2 2 2 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Suppurative | 2 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 4 3 4 4 2 4 2 3 3 3 3 3 4 3 3 3 4 4 |
Mineralization | 4 |
Artery, Inflammation | 2 3 |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6| 3| 0| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|
| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 6| 0| 3| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + M + + + + + M M + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + M + M + + M + + + + M + M + + + A|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A|
Developmental Malformation | X |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 4 |
Infarct | 2 2 2 |
Pigmentation, Hemosiderin | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + + + + M + M + + + + M|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Cyst Epithelial Inclusion | X X |
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Diaphragm, Developmental Malformation| X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 |
Hemorrhage | 2 4 3 |
Mineralization | |
Necrosis | 3 |
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + M + + + + + + A|
Foreign Body | 2 2 |
Inflammation, Suppurative | 2 2 2 3 2 1 2 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hemorrhage | 3 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 4 |
Alveolus, Inflammation, Suppurative | 2 2 1 |
Artery, Mediastinum, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6| 3| 0| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|
| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 6| 0| 3| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5.0MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 1 2 2|
Inflammation, Suppurative | 1 2 1 2 2 3 2 |
Glands, Dilatation | 2 2 3 2 2 2 1 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Hyperplasia | 2 2 1 1 2 2 2 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + A|
Nephropathy, Chronic | 3 3 2 3 3 2 3 2 3 2 3 3 3 3 3 4 3 3 2 3 2 4 3 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 6| 7| 7| 6| |
DAY ON TEST | 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 1| 3| 1| 3| 3| 4| 0| 3| 7| 9| 3| 5| 3| 3| 3| |
| 1| 0| 0| 0| 0| 4| 0| 0| 0| 0| 7| 0| 8| 0| 0| 4| 7| 0| 2| 5| 7| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + A + + +| 46 |
Parasite Metazoan | 3 | 2 2.5|
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + + + + M + + + + + + + + + + +| 45 |
Parasite Metazoan | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + A + A + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + A + A + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis, Focal | | 1 3.0|
Basophilic Focus | 2 2 1 2 2 1 1 2 2 2 2 1 | 22 1.8|
Clear Cell Focus | 2 2 2 1 | 7 1.9|
Developmental Malformation | X | 2 |
Inflammation, Granulomatous | 2 1 2 2 3 3 | 9 2.1|
Inflammation, Suppurative | 3| 1 3.0|
Necrosis | | 2 3.0|
Bile Duct, Fibrosis | | 2 1.5|
Bile Duct, Hyperplasia | 2 2 2 2 2 1 2 2 2 2| 27 2.1|
Hepatocyte, Vacuolization Cytoplasmic| 2 3 | 7 2.6|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Inflammation, Chronic | 4 3 | 2 3.5|
Fat, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 2.0|
Acinus, Atrophy | 2 2 2 2 3 2 2 2 3 3 3| 18 2.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 1 | 3 1.7|
Karyomegaly | | 4 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + I + + + + + + + + + + + +| 48 |
Acanthosis | 3 3 2 | 3 2.7|
Hyperkeratosis | 2 3 2 | 3 2.3|
Inflammation, Suppurative | 4 4 3 | 4 3.5|
Ulcer | 4 | 1 4.0|
Muscularis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 6| 7| 7| 6| |
DAY ON TEST | 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 1| 3| 1| 3| 3| 4| 0| 3| 7| 9| 3| 5| 3| 3| 3| |
| 1| 0| 0| 0| 0| 4| 0| 0| 0| 0| 7| 0| 8| 0| 0| 4| 7| 0| 2| 5| 7| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fibrosis | | 2 3.0|
Inflammation, Chronic | | 2 3.0|
Inflammation, Suppurative | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 3 2 4 2 1 2 2 2 2 2 2 | 28 2.1|
Thrombosis | X| 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Developmental Malformation | | 1 |
Hemorrhage | | 1 3.0|
Hyperplasia | 2 3 | 5 2.0|
Vacuolization Cytoplasmic | 2 2 1 2 1 2 4 3 | 13 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Focal | | 1 2.0|
Hyperplasia | 2 2 2 | 12 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + + M + + M + M + + M + +| 37 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 3 2 2 2 2 | 6 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | M + M + + M + + + + M + + + + + M + + + + + + + +| 39 |
Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X X X X | 4 |
Inflammation, Suppurative | 4 4 4 4 2 4 3 4| 10 3.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 3 4 3 1 | 8 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 6| 7| 7| 6| |
DAY ON TEST | 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 1| 3| 1| 3| 3| 4| 0| 3| 7| 9| 3| 5| 3| 3| 3| |
| 1| 0| 0| 0| 0| 4| 0| 0| 0| 0| 7| 0| 8| 0| 0| 4| 7| 0| 2| 5| 7| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 3 4 3 3 | 7 2.7|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 4 3 3 4 2 3 3 2 4 4 3 4 3 4 4 4 3 3 4 3 | 41 3.3|
Mineralization | | 1 4.0|
Artery, Inflammation | 4 | 3 3.0|
Interstitial Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + M + + + + + + + + + + + M + +| 45 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Developmental Malformation | | 1 |
Fibrosis | 4 | 2 3.5|
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage | | 1 4.0|
Infarct | | 3 2.0|
Pigmentation, Hemosiderin | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + M + + + + + + + M + M M M + +| 41 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 3.0|
Cyst Epithelial Inclusion | | 2 |
Hyperkeratosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Diaphragm, Developmental Malformation| | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 | 3 3.0|
Hemorrhage | 3 1 4 | 6 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05095-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC EPINEPHRINE HCL Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:26:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 6| 7| 7| 6| |
DAY ON TEST | 1| 3| 3| 3| 3| 7| 3| 3| 3| 3| 1| 3| 1| 3| 3| 4| 0| 3| 7| 9| 3| 5| 3| 3| 3| |
| 1| 0| 0| 0| 0| 4| 0| 0| 0| 0| 7| 0| 8| 0| 0| 4| 7| 0| 2| 5| 7| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5.0MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Mineralization | 4 | 1 4.0|
Necrosis | | 1 3.0|
Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Foreign Body | 2 | 3 2.0|
Inflammation, Suppurative | 3 2 2 2 2 | 13 2.1|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 3 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 3.0|
Alveolus, Inflammation, Suppurative | 2 2| 5 1.8|
Artery, Mediastinum, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 2 2 2 2 2 | 10 1.9|
Inflammation, Suppurative | 3 2 2 4 4 3 3 2 2 2| 17 2.4|
Glands, Dilatation | 1 2 2 2 2 2 2 2 3 2 2 2 2 2 2 3 2 2 2 2 2| 44 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
Olfactory Epithelium, Metaplasia | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 4 2 3 2 2 3| 15 2.1|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 3 |
Lens, Cataract | 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Nephropathy, Chronic | 3 3 3 2 3 2 3 3 4 3 2 3 2 2 4 2 2 3 3 3 2 3 3 3 3| 49 2.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
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