TR 380 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/12/94
EXP: 05095 EPINEPHRINE HCL TIME: 23:41:20
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 55663
CONT: N01-ES-38061 CAS: 55-31-2
PATHOLOGIST: R. RENNE
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/12/94
EXP: 05095 EPINEPHRINE HCL TIME: 23:41:20
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 55663
CONT: N01-ES-38061 CAS: 55-31-2
PATHOLOGIST: R. RENNE
EPINEPHRINE HCL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 463 540 653 659 661 679 693 696 702 707 |
| 707 714 717 717 717 717 717 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.5MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 535 598 601 609 623 630 644 651 659 668 |
| 672 672 677 681 686 693 693 699 699 702 |
| 710 717 720 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5.0MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 500 556 560 566 611 630 630 637 644 650 |
| 672 674 695 703 707 714 717 718 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
EPINEPHRINE HCL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 96.0 90.0 66.0 |
| | |
| | |
|1.5MG/M3 | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 94.0 82.0 54.0 |
| | |
| | |
|5.0MG/M3 | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 92.0 80.0 64.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 1.5MG/M3 5.0MG/M3 |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.0% 54.0% 64.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.959 P=0.178 P=0.773 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 674.1 662.6 643.6 |
|NATURAL DEATHS (C) | (16.9) ( 9.5) (15.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 710.3 698.4 698.2 |
|(STANDARD ERROR) | ( 6.8) ( 6.4) ( 7.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
EPINEPHRINE HCL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 258 476 476 577 582 603 624 637 644 651 |
| 670 671 671 682 693 714 715 715 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.5MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 126 430 524 528 535 553 553 581 623 651 |
| 653 679 679 714 714 714 717 717 717 720 |
| 720 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5.0MG/M3 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 356 572 581 615 622 622 637 644 654 657 |
| 662 665 679 679 682 715 715 720 725 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
EPINEPHRINE HCL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 98.0 98.0 98.0 94.0 94.0 88.0 80.0 64.0 |
| | |
| | |
|1.5MG/M3 | 100.0 98.0 98.0 98.0 98.0 96.0 90.0 84.0 78.0 58.0 |
| | |
| | |
|5.0MG/M3 | 100.0 100.0 100.0 98.0 98.0 98.0 98.0 94.0 76.0 60.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 1.5MG/M3 5.0MG/M3 |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 64.0% 58.0% 60.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.962 P=0.735 P=0.902 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 614.4 611.8 646.5 |
|NATURAL DEATHS (C) | (26.9) (30.8) (18.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 687.7 679.8 696.0 |
|(STANDARD ERROR) | (12.3) (15.2) ( 9.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
EPINEPHRINE HCL
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
1.5MG/M3 = 2
5.0MG/M3 = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 2
|
| 1 3 21 3 2
| 1 1
95 +
| 33 22 1 1
| 3 232
|
90 + 322 1 1
|
| 2 2 1 1
| 3322 11
P 85 +
E | 332 2 11
R | 33 22
C |
E 80 + 3 3
N |
T | 33 11
| 22 3 11
S 75 +
U | 22 33
R |
V |
I 70 + 22 33
V |
A | 33
L | 22 1 1
65 +
| 3 3
| 22
|
60 + 22
|
| 22
|
55 +
| 2 2
|
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.
EPINEPHRINE HCL
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
1.5MG/M3 = 2
5.0MG/M3 = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 3
|
| 2 1 3 2 1 3
| 2 2 33
95 +
| 1 22 1 3
| 22 11 33
|
90 + 2 2 1 1
|
P | 1 313
E | 2 2 113
R 85 +
C | 2 2 11 3
E | 2 11
N |
T 80 + 12 31
|
S | 2 2
U | 3 3
R 75 +
V | 121 2
I | 311
V |
A 70 + 31 13
L |
| 11
|
65 +
| 13 1
|
|
60 + 3 3
|
| 2 2
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 12 obs hidden.
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