Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/3023

TR 381 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                              CARVONE


NTP Experiment-Test: 05032-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: GAVAGE                                                                                                     Time: 19:21:15




       Facility:  International Research and Development Corp.

       Chemical CAS #:  99490

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          23            9            4                                                  
    Dead                                              13           10            7                                                  
    Accident                                                        2            1                                                  
  Survivors                                                                                                                         
    Moribund                                                        1                                                               
    Terminal Sacrifice                                14           28           38                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (49)         (49)                                                
      Perforation, Focal                                            1 (2%)       1 (2%)                                             
      Mucosa, Muscularis, Inflammation, Acute,                                                                                      
           Diffuse                                     1 (2%)                                                                       
      Periesophageal Tissue, Abscess, Focal            1 (2%)                                                                       
      Periesophageal Tissue, Abscess, Multifocal       2 (4%)                                                                       
      Periesophageal Tissue, Inflammation, Chronic                  1 (2%)                                                          
   Gallbladder                                        (31)         (34)         (42)                                                
      Infiltration Cellular, Diffuse, Lymphocyte       1 (3%)       1 (3%)       1 (2%)                                             
      Infiltration Cellular, Focal, Lymphocyte                      2 (6%)       2 (5%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte    2 (6%)       1 (3%)       1 (2%)                                             
      Inflammation, Acute, Diffuse                     1 (3%)                    1 (2%)                                             
      Inflammation, Acute, Focal                                    3 (9%)       1 (2%)                                             
   Intestine Large, Cecum                             (46)         (44)         (46)                                                
      Ulcer, Diffuse                                                1 (2%)                                                          
      Lymphoid Nodule, Hyperplasia, Focal, Lymphoid                              1 (2%)                                             
      Lymphoid Nodule, Hyperplasia, Lymphoid,                                                                                       
          Multifocal                                                             1 (2%)                                             
      Wall, Abscess, Multifocal                                     1 (2%)                                                          
   Intestine Large, Rectum                            (47)         (45)         (45)                                                
      Inflammation, Acute, Focal                       5 (11%)     15 (33%)     22 (49%)                                            
   Intestine Small, Jejunum                           (41)         (40)         (47)                                                
      Peyer's Patch, Hyperplasia, Diffuse, Lymphoid                              1 (2%)                                             
      Peyer's Patch, Hyperplasia, Focal, Lymphoid                                2 (4%)                                             
      Peyer's Patch, Hyperplasia, Lymphoid,                                                                                         
          Multifocal                                                1 (3%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis, Multifocal                                                    1 (2%)                                             
      Fatty Change, Diffuse                                                      1 (2%)                                             
      Hematopoietic Cell Proliferation, Multifocal    18 (36%)     12 (24%)      1 (2%)                                             
      Hypertrophy, Focal                                                         1 (2%)                                             
      Infiltration Cellular, Focal, Lymphocyte         3 (6%)       1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Infiltration Cellular, Multifocal, Lymphocyte    2 (4%)       4 (8%)       4 (8%)                                             
      Inflammation, Acute, Multifocal                  1 (2%)                    2 (4%)                                             
      Bile Duct, Infiltration Cellular, Multifocal,                                                                                 
           Lymphocyte                                  3 (6%)       4 (8%)       5 (10%)                                            
      Bile Duct, Mineralization, Multifocal                         1 (2%)                                                          
      Hepatocyte, Focal Cellular Change                                          1 (2%)                                             
      Serosa, Abscess, Focal                           1 (2%)                                                                       
      Serosa, Inflammation, Acute, Focal                            1 (2%)                                                          
      Serosa, Inflammation, Acute, Multifocal          2 (4%)                                                                       
      Serosa, Inflammation, Chronic, Focal             1 (2%)                                                                       
   Mesentery                                          (20)         (12)         (2)                                                 
      Abscess, Focal                                   1 (5%)                                                                       
      Abscess, Multifocal                             19 (95%)      8 (67%)                                                         
      Cyst, Single                                                  1 (8%)                                                          
      Inflammation, Acute, Multifocal                                            1 (50%)                                            
      Inflammation, Granulomatous, Multifocal                       1 (8%)                                                          
      Pigmentation, Diffuse                                         1 (8%)                                                          
      Fat, Necrosis, Multifocal                                                  1 (50%)                                            
   Pancreas                                           (49)         (49)         (49)                                                
      Abscess, Multifocal                              3 (6%)       1 (2%)                                                          
      Atrophy, Diffuse                                 1 (2%)                    1 (2%)                                             
      Atrophy, Focal                                   1 (2%)                    3 (6%)                                             
      Atrophy, Multifocal                              2 (4%)                                                                       
      Inflammation, Acute, Diffuse                     4 (8%)       1 (2%)                                                          
      Inflammation, Acute, Focal                                    1 (2%)                                                          
      Inflammation, Acute, Multifocal                  2 (4%)                                                                       
      Inflammation, Chronic, Diffuse                   1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic, Focal                     1 (2%)       5 (10%)      2 (4%)                                             
      Inflammation, Chronic, Multifocal                4 (8%)       1 (2%)       1 (2%)                                             
      Necrosis, Focal                                                            1 (2%)                                             
      Necrosis, Multifocal                             1 (2%)                                                                       
      Duct, Cyst, Single                                                         2 (4%)                                             
      Duct, Dilatation                                 1 (2%)                    1 (2%)                                             
      Duct, Inflammation, Chronic, Focal                            1 (2%)       2 (4%)                                             
      Duct, Inflammation, Chronic, Multifocal                       1 (2%)       3 (6%)                                             
   Salivary Glands                                    (49)         (45)         (50)                                                
      Infiltration Cellular, Focal, Lymphocyte         4 (8%)       5 (11%)      9 (18%)                                            
      Infiltration Cellular, Multifocal, Lymphocyte   11 (22%)      8 (18%)     17 (34%)                                            
   Stomach, Forestomach                               (47)         (47)         (49)                                                
      Abscess, Focal                                   1 (2%)       1 (2%)       1 (2%)                                             
      Abscess, Multifocal                                                        1 (2%)                                             
      Acanthosis, Focal                                5 (11%)      2 (4%)       7 (14%)                                            
      Acanthosis, Multifocal                           1 (2%)                                                                       
      Cyst Epithelial Inclusion, Focal                              1 (2%)       1 (2%)                                             
      Hyperkeratosis, Focal                            1 (2%)       3 (6%)       1 (2%)                                             
      Hyperplasia, Basal Cell                                       1 (2%)                                                          
      Inflammation, Acute, Focal                       1 (2%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic, Focal                     5 (11%)      3 (6%)       1 (2%)                                             
   Stomach, Glandular                                 (48)         (49)         (50)                                                
      Inflammation, Acute, Focal                       1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Acute, Multifocal                               1 (2%)                                                          
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (49)         (50)                                                
      Aorta, Media, Mineralization, Diffuse            1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)                                                
      Artery, Inflammation, Chronic, Focal             1 (2%)       3 (6%)                                                          
      Atrium Left, Bacterium, Focal                                              1 (2%)                                             
      Atrium Left, Thrombosis                                       1 (2%)       1 (2%)                                             
      Epicardium, Inflammation, Acute, Diffuse         1 (2%)                                                                       
      Epicardium, Inflammation, Acute, Focal           1 (2%)                                                                       
      Epicardium, Inflammation, Acute, Multifocal      3 (6%)                                                                       
      Epicardium, Inflammation, Chronic, Diffuse       1 (2%)                                                                       
      Epicardium, Inflammation, Chronic, Focal                      2 (4%)                                                          
      Epicardium, Inflammation, Chronic, Multifocal    1 (2%)                                                                       
      Myocardium, Inflammation, Acute, Diffuse                      1 (2%)                                                          
      Myocardium, Inflammation, Acute, Focal           1 (2%)                                                                       
      Myocardium, Inflammation, Chronic, Focal                                   2 (4%)                                             
      Myocardium, Inflammation, Chronic, Multifocal                 1 (2%)                                                          
      Pericardium, Inflammation, Chronic, Focal                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (49)         (50)                                                
      Capsule, Inflammation, Chronic, Multifocal                    1 (2%)                                                          
   Adrenal Gland, Cortex                              (50)         (49)         (50)                                                
      Cyst, Multiple                                                             1 (2%)                                             
      Cyst, Single                                     1 (2%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation, Diffuse        2 (4%)                                                                       
      Hematopoietic Cell Proliferation, Focal          1 (2%)       1 (2%)                                                          
      Hematopoietic Cell Proliferation, Multifocal     2 (4%)       1 (2%)       1 (2%)                                             
      Hypertrophy, Focal                                            1 (2%)       1 (2%)                                             
      Bilateral, Hematopoietic Cell Proliferation,                                                                                  
           Diffuse                                     1 (2%)       1 (2%)                                                          
      Bilateral, Hematopoietic Cell Proliferation,                                                                                  
           Multifocal                                  9 (18%)      2 (4%)                                                          
      Bilateral, Vacuolization Cytoplasmic, Diffuse    2 (4%)       1 (2%)       1 (2%)                                             
      Bilateral, Spindle Cell, Hyperplasia, Diffuse   32 (64%)     33 (67%)     39 (78%)                                            
      Bilateral, Spindle Cell, Hyperplasia,                                                                                         
          Multifocal                                  16 (32%)     10 (20%)      7 (14%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Spindle Cell, Hyperplasia, Diffuse               1 (2%)       4 (8%)       3 (6%)                                             
      Spindle Cell, Hyperplasia, Multifocal            1 (2%)       1 (2%)                                                          
   Adrenal Gland, Medulla                             (49)         (48)         (50)                                                
      Hematopoietic Cell Proliferation, Focal                       1 (2%)                                                          
   Pituitary Gland                                    (46)         (49)         (48)                                                
      Hypertrophy, Focal                               1 (2%)       1 (2%)       1 (2%)                                             
      Craniopharyngeal Duct, Cyst                                   1 (2%)                                                          
   Thyroid Gland                                      (49)         (46)         (50)                                                
      Granuloma, Focal                                 1 (2%)                                                                       
      Hyperplasia, Multifocal                                       1 (2%)                                                          
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Inflammation, Chronic, Focal                     1 (2%)       1 (2%)                                                          
      Ultimobranchial Cyst                            13 (27%)     18 (39%)      4 (8%)                                             
      Follicle, Cyst                                   1 (2%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (48)         (48)                                                
      Abscess, Focal                                   4 (8%)                                                                       
      Abscess, Multifocal                             16 (32%)      7 (15%)                                                         
      Cyst, Multiple                                   1 (2%)                    1 (2%)                                             
      Cyst, Single                                     7 (14%)      4 (8%)      10 (21%)                                            
      Mineralization, Focal                                         2 (4%)                                                          
      Bilateral, Abscess, Multifocal                   6 (12%)      2 (4%)       1 (2%)                                             
      Bilateral, Cyst, Multiple                        2 (4%)       1 (2%)       1 (2%)                                             
      Germinal Epithelium, Hyperplasia, Focal                       1 (2%)                                                          
      Periovarian Tissue, Inflammation, Chronic,                                                                                    
           Diffuse                                                  1 (2%)                                                          
   Oviduct                                                         (1)                                                              
      Inflammation, Acute, Diffuse                                  1 (100%)                                                        
   Uterus                                             (50)         (50)         (50)                                                
      Abscess, Focal                                   1 (2%)       1 (2%)                                                          
      Abscess, Multifocal                              9 (18%)      2 (4%)                                                          
      Dilatation                                       5 (10%)      7 (14%)     14 (28%)                                            
      Inflammation, Acute, Diffuse                     3 (6%)       3 (6%)                                                          
      Endometrium, Edema, Diffuse                                   1 (2%)                                                          
      Endometrium, Hyperplasia, Cystic, Diffuse       14 (28%)     26 (52%)     27 (54%)                                            
      Endometrium, Hyperplasia, Cystic, Multifocal     1 (2%)       1 (2%)       1 (2%)                                             
      Lumen, Exudate                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hypoplasia, Diffuse                              1 (2%)                                                                       
      Myelofibrosis, Focal                             2 (4%)                                                                       
      Myeloid Cell, Hyperplasia, Diffuse               6 (12%)      4 (8%)       1 (2%)                                             
   Lymph Node                                         (47)         (47)         (48)                                                
      Bronchial, Abscess, Focal                        1 (2%)                                                                       
      Bronchial, Hyperplasia, Diffuse, Lymphoid        1 (2%)                                                                       
      Bronchial, Infiltration Cellular, Diffuse,                                                                                    
           Plasma Cell                                 1 (2%)                                                                       
      Iliac, Hyperplasia, Lymphoid, Multifocal         1 (2%)                                                                       
      Iliac, Infiltration Cellular, Diffuse,                                                                                        
          Plasma Cell                                  4 (9%)       1 (2%)                                                          
      Inguinal, Infiltration Cellular, Diffuse,                                                                                     
           Plasma Cell                                 2 (4%)                                                                       
      Mediastinal, Abscess, Focal                      1 (2%)                                                                       
      Mediastinal, Abscess, Multifocal                              1 (2%)                                                          
      Mediastinal, Hyperplasia, Diffuse, Lymphoid                   1 (2%)                                                          
      Mediastinal, Infiltration Cellular, Diffuse,                                                                                  
           Plasma Cell                                 1 (2%)                                                                       
      Renal, Infiltration Cellular, Diffuse,                                                                                        
          Plasma Cell                                  4 (9%)       1 (2%)                                                          
   Lymph Node, Mandibular                             (7)          (15)                                                             
      Hyperplasia, Diffuse, Lymphoid                   1 (14%)                                                                      
      Hyperplasia, Focal, Lymphoid                                  1 (7%)                                                          
      Hyperplasia, Lymphoid, Multifocal                2 (29%)      8 (53%)                                                         
      Infiltration Cellular, Diffuse, Plasma Cell      4 (57%)      7 (47%)                                                         
      Sinus, Ectasia, Diffuse                          1 (14%)                                                                      
   Lymph Node, Mesenteric                             (46)         (47)         (48)                                                
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)       1 (2%)                                                          
      Hyperplasia, Diffuse, Lymphoid                   1 (2%)       1 (2%)       2 (4%)                                             
      Hyperplasia, Diffuse, Re Cell                    7 (15%)      1 (2%)       1 (2%)                                             
      Hyperplasia, Focal, Lymphoid                     2 (4%)                                                                       
      Hyperplasia, Lymphoid, Multifocal                2 (4%)       3 (6%)      14 (29%)                                            
      Infiltration Cellular, Diffuse, Plasma Cell      2 (4%)       1 (2%)                                                          
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Necrosis, Caseous, Diffuse                       1 (2%)                                                                       
   Spleen                                             (50)         (49)         (50)                                                
      Depletion Lymphoid, Diffuse                      1 (2%)                                                                       
      Hematopoietic Cell Proliferation, Diffuse       32 (64%)     18 (37%)      7 (14%)                                            
      Hyperplasia, Diffuse, Lymphoid                   4 (8%)       3 (6%)      16 (32%)                                            
      Hyperplasia, Lymphoid, Multifocal                1 (2%)       2 (4%)       3 (6%)                                             
      Hyperplasia, Multifocal, Re Cell                                           1 (2%)                                             
      Pigmentation, Diffuse                            6 (12%)      3 (6%)       3 (6%)                                             
      Artery, Trabecula, Amyloid Deposition,                                                                                        
          Multifocal                                   1 (2%)                                                                       
      Capsule, Inflammation, Acute, Diffuse            1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Capsule, Inflammation, Acute, Multifocal         1 (2%)                                                                       
      Capsule, Inflammation, Chronic, Diffuse          1 (2%)                                                                       
      Capsule, Inflammation, Chronic, Focal                         2 (4%)                                                          
   Thymus                                             (35)         (42)         (46)                                                
      Abscess, Focal                                                1 (2%)                                                          
      Abscess, Multifocal                              1 (3%)                                                                       
      Atrophy, Diffuse                                17 (49%)     13 (31%)      6 (13%)                                            
      Hyperplasia, Focal, Lymphoid                                  1 (2%)       2 (4%)                                             
      Hyperplasia, Focal, Re Cell                                                1 (2%)                                             
      Hyperplasia, Lymphoid, Multifocal                2 (6%)                                                                       
      Mediastinum, Abscess, Focal                      1 (3%)                                                                       
      Mediastinum, Abscess, Multifocal                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (46)         (42)                                                
      Hyperplasia, Diffuse                            16 (33%)      8 (17%)      3 (7%)                                             
      Inflammation, Acute                                           1 (2%)                                                          
   Skin                                               (16)         (34)         (14)                                                
      Acanthosis, Diffuse                                           2 (6%)       1 (7%)                                             
      Acanthosis, Focal                                1 (6%)                    2 (14%)                                            
      Acanthosis, Multifocal                           1 (6%)       3 (9%)       8 (57%)                                            
      Hyperkeratosis, Diffuse                                       1 (3%)       1 (7%)                                             
      Hyperkeratosis, Focal                                         1 (3%)                                                          
      Hyperkeratosis, Multifocal                                    2 (6%)                                                          
      Inflammation, Acute, Multifocal                                            1 (7%)                                             
      Inflammation, Chronic, Diffuse                                5 (15%)      2 (14%)                                            
      Inflammation, Chronic, Focal                                  1 (3%)                                                          
      Inflammation, Chronic, Multifocal                             1 (3%)       1 (7%)                                             
      Ulcer, Focal                                                               1 (7%)                                             
      Back, Subcutaneous Tissue, Abscess, Focal        1 (6%)                                                                       
      Hair Follicle, Acanthosis, Diffuse                                         1 (7%)                                             
      Hair Follicle, Atrophy, Diffuse                  3 (19%)      3 (9%)       6 (43%)                                            
      Hair Follicle, Atrophy, Focal                    1 (6%)                                                                       
      Hair Follicle, Atrophy, Multifocal                                         1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Femur, Fibrous Osteodystrophy, Diffuse           3 (6%)                                                                       
      Femur, Fracture Healed                                        1 (2%)                                                          
   Skeletal Muscle                                    (1)          (1)          (2)                                                 
      Inflammation, Acute, Diffuse                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)                                                
      Bilateral, Thalamus, Mineralization,                                                                                          
          Multifocal                                  12 (24%)     17 (35%)     15 (30%)                                            
      Meninges, Abscess, Focal                         1 (2%)                                                                       
      Meninges, Inflammation, Acute, Focal             1 (2%)                                                                       
      Meninges, Cerebrum, Abscess, Multifocal                       1 (2%)                                                          
      Thalamus, Hemorrhage, Multifocal                              1 (2%)                                                          
      Thalamus, Mineralization, Focal                  3 (6%)       3 (6%)       4 (8%)                                             
      Thalamus, Mineralization, Multifocal             5 (10%)      6 (12%)      6 (12%)                                            
      Ventricle, Abscess, Multifocal                   1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Abscess, Multifocal                              1 (2%)       2 (4%)                                                          
      Bacterium, Multifocal                            1 (2%)                                                                       
      Congestion, Multifocal                           1 (2%)                                                                       
      Hemorrhage, Diffuse                                           1 (2%)                                                          
      Hemorrhage, Focal                                2 (4%)                                                                       
      Hemorrhage, Multifocal                           2 (4%)                                                                       
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (2%)                                                          
      Alveolus, Inflammation, Acute, Focal                                       1 (2%)                                             
      Artery, Adventitia, Inflammation, Chronic,                                                                                    
           Multifocal                                  1 (2%)                                                                       
      Artery, Media, Hypertrophy, Multifocal           4 (8%)                                                                       
      Peribronchial, Infiltration Cellular,                                                                                         
          Diffuse, Lymphocyte                                       1 (2%)       1 (2%)                                             
      Peribronchial, Infiltration Cellular,                                                                                         
          Multifocal, Lymphocyte                      30 (60%)     28 (56%)     35 (70%)                                            
      Peribronchiolar, Infiltration Cellular,                                                                                       
          Multifocal, Lymphocyte                       2 (4%)                    2 (4%)                                             
      Perivascular, Infiltration Cellular, Diffuse,                                                                                 
           Lymphocyte                                  1 (2%)                    1 (2%)                                             
      Perivascular, Infiltration Cellular,                                                                                          
          Multifocal, Lymphocyte                      16 (32%)     23 (46%)      8 (16%)                                            
      Pleura, Foreign Body, Focal                      1 (2%)                    1 (2%)                                             
      Pleura, Granuloma, Focal                         1 (2%)                                                                       
      Pleura, Inflammation, Acute, Diffuse             1 (2%)                                                                       
      Pleura, Inflammation, Acute, Multifocal                                    1 (2%)                                             
      Pleura, Inflammation, Chronic, Diffuse                        1 (2%)                                                          
   Nose                                               (49)         (49)         (50)                                                
      Foreign Body                                    35 (71%)     35 (71%)     33 (66%)                                            
      Hyperplasia, Focal, Lymphoid                                               1 (2%)                                             
      Glands, Hyperplasia                             19 (39%)     45 (92%)     49 (98%)                                            
      Nasolacrimal Duct, Exudate, Diffuse              1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Olfactory Epithelium, Atrophy                   25 (51%)     46 (94%)     49 (98%)                                            
      Turbinate, Exudate                              15 (31%)     22 (45%)     17 (34%)                                            
      Turbinate, Fungus, Focal                                                   1 (2%)                                             
      Turbinate, Fungus, Multifocal                    1 (2%)                                                                       
      Turbinate, Hemorrhage, Diffuse                                2 (4%)                                                          
      Turbinate, Hemorrhage, Focal                     1 (2%)                                                                       
      Turbinate, Hemorrhage, Multifocal                             1 (2%)                                                          
      Turbinate, Inflammation, Acute, Diffuse          2 (4%)                    2 (4%)                                             
      Turbinate, Inflammation, Acute, Focal                                      1 (2%)                                             
      Turbinate, Inflammation, Acute, Multifocal       5 (10%)     22 (45%)     39 (78%)                                            
      Turbinate, Inflammation, Chronic, Diffuse        1 (2%)      10 (20%)      3 (6%)                                             
      Turbinate, Inflammation, Chronic, Focal          1 (2%)       4 (8%)       2 (4%)                                             
      Turbinate, Inflammation, Chronic, Multifocal    29 (59%)     17 (35%)     16 (32%)                                            
      Turbinate, Ulcer, Focal                          1 (2%)                                                                       
   Trachea                                            (49)         (50)         (50)                                                
      Inflammation, Acute, Focal                                                 1 (2%)                                             
      Inflammation, Chronic, Diffuse                   3 (6%)       3 (6%)       1 (2%)                                             
      Inflammation, Chronic, Focal                     2 (4%)       5 (10%)      1 (2%)                                             
      Inflammation, Chronic, Multifocal                6 (12%)      7 (14%)     10 (20%)                                            
      Peritracheal Tissue, Abscess, Multifocal         1 (2%)                                                                       
      Peritracheal Tissue, Foreign Body, Focal                                   1 (2%)                                             
      Peritracheal Tissue, Hemorrhage, Focal                                     1 (2%)                                             
      Peritracheal Tissue, Inflammation, Acute,                                                                                     
           Focal                                       1 (2%)                                                                       
      Peritracheal Tissue, Inflammation, Chronic,                                                                                   
           Diffuse                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Cyst, Multiple                                   1 (2%)                    1 (2%)                                             
      Inflammation, Chronic, Focal                     1 (2%)       2 (4%)       4 (8%)                                             
      Inflammation, Chronic, Multifocal                2 (4%)      10 (20%)      7 (14%)                                            
      Bilateral, Abscess, Multifocal                   1 (2%)                                                                       
      Bilateral, Glomerulosclerosis, Diffuse           2 (4%)       1 (2%)                                                          
      Bilateral, Hematopoietic Cell Proliferation,                                                                                  
           Diffuse                                                  1 (2%)                                                          
      Bilateral, Inflammation, Chronic, Diffuse        1 (2%)                                                                       
      Bilateral, Inflammation, Chronic, Multifocal    33 (66%)     21 (42%)     21 (42%)                                            
      Bilateral, Cortex, Abscess, Multifocal                        1 (2%)                                                          
      Bilateral, Pelvis, Bacterium, Multifocal         1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Bilateral, Renal Tubule, Bacterium,                                                                                           
          Multifocal                                                1 (2%)                                                          
      Bilateral, Renal Tubule, Casts Protein,                                                                                       
          Multifocal                                                1 (2%)                                                          
      Bilateral, Renal Tubule, Mineralization,                                                                                      
           Multifocal                                                            1 (2%)                                             
      Bilateral, Renal Tubule, Pigmentation,                                                                                        
          Multifocal                                                2 (4%)                                                          
      Bilateral, Renal Tubule, Regeneration,                                                                                        
          Multifocal                                                1 (2%)                                                          
      Capsule, Interstitial Tissue, Inflammation,                                                                                   
           Chronic                                                  1 (2%)                                                          
      Glomerulus, Renal Tubule, Amyloid Deposition,                                                                                 
           Diffuse                                     1 (2%)                                                                       
      Interstitial Tissue, Renal Tubule,                                                                                            
          Pigmentation, Multifocal                     1 (2%)                                                                       
      Left, Hydronephrosis                             1 (2%)                                                                       
      Pelvis, Bacterium, Focal                         1 (2%)                                                                       
      Pelvis, Bacterium, Multifocal                    1 (2%)       1 (2%)       1 (2%)                                             
      Pelvis, Concretion, Multifocal                   1 (2%)                                                                       
      Renal Tubule, Bacterium, Multifocal              1 (2%)                                                                       
      Renal Tubule, Casts Protein, Multifocal          1 (2%)                                                                       
      Renal Tubule, Degeneration, Focal                3 (6%)                                                                       
      Renal Tubule, Degeneration, Multifocal                        1 (2%)                                                          
      Renal Tubule, Regeneration, Focal                1 (2%)       1 (2%)                                                          
      Renal Tubule, Regeneration, Multifocal           2 (4%)                                                                       
   Ureter                                                                       (1)                                                 
      Dilatation                                                                 1 (100%)                                           
   Urinary Bladder                                    (46)         (46)         (48)                                                
      Abscess, Focal                                   1 (2%)       1 (2%)                                                          
      Infiltration Cellular, Focal, Lymphocyte         4 (9%)       6 (13%)      5 (10%)                                            
      Infiltration Cellular, Multifocal, Lymphocyte   16 (35%)     22 (48%)     19 (40%)                                            
      Serosa, Inflammation, Chronic, Multifocal                     1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               6            6            7                                                  
    Moribund                                           7            2            3                                                  
    Accident                                                                     4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           42           36                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (49)                                                
      Perforation, Focal                                            1 (2%)                                                          
      Periesophageal Tissue, Hemorrhage, Focal                                   1 (2%)                                             
      Periesophageal Tissue, Inflammation, Acute,                                                                                   
           Diffuse                                                               1 (2%)                                             
   Gallbladder                                        (38)         (36)         (43)                                                
      Infiltration Cellular, Diffuse, Lymphocyte       4 (11%)      2 (6%)       1 (2%)                                             
      Infiltration Cellular, Focal, Lymphocyte         1 (3%)       3 (8%)                                                          
      Infiltration Cellular, Multifocal, Lymphocyte    1 (3%)       1 (3%)                                                          
      Inflammation, Acute, Diffuse                     1 (3%)       4 (11%)                                                         
      Inflammation, Acute, Focal                                                 1 (2%)                                             
   Intestine Large, Cecum                             (50)         (46)         (49)                                                
      Lymphoid Nodule, Hyperplasia, Focal, Lymphoid                 1 (2%)                                                          
      Lymphoid Nodule, Hyperplasia, Lymphoid,                                                                                       
          Multifocal                                                1 (2%)                                                          
   Intestine Large, Rectum                            (48)         (45)         (44)                                                
      Inflammation, Acute, Focal                      19 (40%)     15 (33%)     18 (41%)                                            
   Intestine Small, Duodenum                          (48)         (47)         (46)                                                
      Peyer's Patch, Hyperplasia, Lymphoid,                                                                                         
          Multifocal                                                             1 (2%)                                             
   Intestine Small, Jejunum                           (48)         (48)         (48)                                                
      Peyer's Patch, Hyperplasia, Focal, Lymphoid                   1 (2%)       2 (4%)                                             
   Liver                                              (50)         (50)         (49)                                                
      Basophilic Focus                                 1 (2%)                                                                       
      Cyst, Multiple                                   1 (2%)                                                                       
      Fatty Change, Multifocal                                      1 (2%)       1 (2%)                                             
      Infarct, Focal                                   2 (4%)                    1 (2%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte                 3 (6%)                                                          
      Inflammation, Acute, Focal                                    1 (2%)                                                          
      Necrosis, Coagulative, Diffuse                   1 (2%)                                                                       
      Necrosis, Coagulative, Multifocal                                          2 (4%)                                             
      Bile Duct, Infiltration Cellular, Multifocal,                                                                                 
           Lymphocyte                                  1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (1)                                                                           
      Inflammation, Acute, Diffuse                     1 (100%)                                                                     
   Pancreas                                           (50)         (50)         (48)                                                
      Abscess, Focal                                   1 (2%)                                                                       
      Atrophy, Focal                                   2 (4%)       3 (6%)       2 (4%)                                             
      Inflammation, Chronic, Focal                     1 (2%)       7 (14%)                                                         
      Inflammation, Chronic, Multifocal                2 (4%)       2 (4%)                                                          
      Necrosis, Focal                                  1 (2%)                                                                       
      Vacuolization Cytoplasmic, Multifocal            1 (2%)       1 (2%)                                                          
      Artery, Media, Mineralization, Multifocal                                  1 (2%)                                             
      Duct, Inflammation, Chronic, Focal                                         1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)                                                
      Infiltration Cellular, Focal, Lymphocyte         5 (10%)     10 (20%)      7 (14%)                                            
      Infiltration Cellular, Multifocal, Lymphocyte   17 (34%)     25 (50%)     11 (22%)                                            
   Stomach, Forestomach                               (48)         (48)         (47)                                                
      Abscess, Focal                                   4 (8%)       3 (6%)                                                          
      Abscess, Multifocal                              1 (2%)       3 (6%)                                                          
      Acanthosis, Focal                                2 (4%)       3 (6%)       5 (11%)                                            
      Acanthosis, Multifocal                           2 (4%)       2 (4%)       6 (13%)                                            
      Cyst Epithelial Inclusion, Focal                 1 (2%)                    1 (2%)                                             
      Hyperkeratosis, Focal                                         2 (4%)                                                          
      Inflammation, Acute, Focal                                    1 (2%)       1 (2%)                                             
      Inflammation, Acute, Multifocal                                            1 (2%)                                             
      Inflammation, Chronic, Focal                     2 (4%)                    6 (13%)                                            
      Inflammation, Chronic, Multifocal                1 (2%)                    1 (2%)                                             
      Serosa, Inflammation, Acute, Diffuse             1 (2%)                                                                       
   Stomach, Glandular                                 (49)         (49)         (48)                                                
      Inflammation, Acute, Focal                                                 2 (4%)                                             
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
      Artery, Adventitia, Inflammation, Chronic,                                                                                    
           Multifocal                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (49)         (50)         (50)                                                
      Mesenteric Artery, Aorta, Adventitia,                                                                                         
          Inflammation, Chronic, Multifocal            1 (2%)                                                                       
      Mesenteric Artery, Aorta, Media, Hypertrophy,                                                                                 
           Multifocal                                  1 (2%)                                                                       
      Mesenteric Artery, Renal Artery, Adventitia,                                                                                  
           Inflammation, Chronic, Multifocal           1 (2%)                                                                       
      Mesenteric Artery, Renal Artery, Media,                                                                                       
          Hypertrophy, Diffuse                         1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)                                                
      Artery, Inflammation, Chronic, Diffuse           2 (4%)       1 (2%)                                                          
      Endocardium, Inflammation, Acute, Focal                                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Endocardium, Inflammation, Chronic, Focal        1 (2%)                                                                       
      Epicardium, Inflammation, Acute, Diffuse         2 (4%)                    1 (2%)                                             
      Epicardium, Inflammation, Acute, Focal           1 (2%)                    2 (4%)                                             
      Ventricle Left, Myocardium, Hemorrhage, Focal                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Hypertrophy, Focal                               1 (2%)       3 (6%)       2 (4%)                                             
      Bilateral, Hypertrophy, Multifocal                            1 (2%)                                                          
      Bilateral, Spindle Cell, Hyperplasia, Diffuse                 1 (2%)                                                          
      Bilateral, Spindle Cell, Hyperplasia, Focal      1 (2%)                                                                       
      Bilateral, Spindle Cell, Hyperplasia,                                                                                         
          Multifocal                                  25 (50%)     30 (60%)     23 (46%)                                            
      Spindle Cell, Hyperplasia, Diffuse                                         1 (2%)                                             
      Spindle Cell, Hyperplasia, Focal                 9 (18%)      8 (16%)      5 (10%)                                            
      Spindle Cell, Hyperplasia, Multifocal           11 (22%)      6 (12%)      4 (8%)                                             
   Adrenal Gland, Medulla                             (48)         (49)         (48)                                                
      Hyperplasia, Focal                               1 (2%)       1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (47)         (49)                                                
      Vacuolization Cytoplasmic, Diffuse               1 (2%)                                                                       
   Parathyroid Gland                                  (27)         (27)         (26)                                                
      Cyst, Single                                                  1 (4%)                                                          
      Infiltration Cellular, Focal, Lymphocyte         1 (4%)                                                                       
   Pituitary Gland                                    (40)         (48)         (48)                                                
      Hypertrophy, Focal                               1 (3%)                                                                       
      Craniopharyngeal Duct, Cyst                      1 (3%)                    1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (49)                                                
      Hyperplasia, Cystic, Focal                                    1 (2%)                                                          
      Infiltration Cellular, Focal, Lymphocyte         1 (2%)       1 (2%)                                                          
      Infiltration Cellular, Multifocal, Lymphocyte    1 (2%)                                                                       
      Ultimobranchial Cyst                             5 (10%)      9 (18%)      7 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
      Atypia Cellular, Multifocal                      1 (2%)                    1 (2%)                                             
      Granuloma Sperm, Focal                                        1 (2%)                                                          
      Inflammation, Chronic, Focal                     4 (8%)       2 (4%)       2 (4%)                                             
      Inflammation, Chronic, Multifocal                1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Spermatocele                                                  1 (2%)                                                          
      Vacuolization Cytoplasmic, Diffuse               1 (2%)                    2 (4%)                                             
      Vacuolization Cytoplasmic, Focal                                           1 (2%)                                             
      Bilateral, Atypia Cellular, Multifocal                                     4 (8%)                                             
      Bilateral, Inflammation, Chronic, Multifocal                  1 (2%)                                                          
      Bilateral, Vacuolization Cytoplasmic, Diffuse    1 (2%)                    1 (2%)                                             
      Bilateral, Vacuolization Cytoplasmic,                                                                                         
          Multifocal                                   1 (2%)       1 (2%)                                                          
      Serosa, Inflammation, Acute, Diffuse             1 (2%)                                                                       
   Penis                                              (1)                                                                           
      Inflammation, Focal                              1 (100%)                                                                     
   Preputial Gland                                    (10)         (4)          (3)                                                 
      Abscess, Focal                                   4 (40%)                   1 (33%)                                            
      Abscess, Multifocal                              1 (10%)      1 (25%)                                                         
      Dilatation                                       1 (10%)      1 (25%)      1 (33%)                                            
      Inflammation, Chronic, Diffuse                   3 (30%)      1 (25%)      1 (33%)                                            
      Inflammation, Chronic, Multifocal                1 (10%)                                                                      
      Bilateral, Abscess, Multifocal                                2 (50%)                                                         
      Bilateral, Dilatation                            1 (10%)                                                                      
   Prostate                                           (49)         (49)         (49)                                                
      Abscess, Multifocal                              1 (2%)                                                                       
      Infiltration Cellular, Focal, Lymphocyte         3 (6%)       4 (8%)       2 (4%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte    2 (4%)       1 (2%)       1 (2%)                                             
      Inflammation, Acute, Diffuse                     2 (4%)                                                                       
   Seminal Vesicle                                    (1)                                                                           
      Abscess, Multifocal                              1 (100%)                                                                     
   Testes                                             (50)         (50)         (50)                                                
      Bilateral, Seminiferous Tubule, Degeneration,                                                                                 
           Diffuse                                                  1 (2%)                                                          
      Bilateral, Seminiferous Tubule,                                                                                               
          Vacuolization Cytoplasmic, Diffuse           2 (4%)       3 (6%)       1 (2%)                                             
      Seminiferous Tubule, Degeneration, Diffuse       1 (2%)       1 (2%)       1 (2%)                                             
      Seminiferous Tubule, Degeneration, Focal         1 (2%)       1 (2%)       1 (2%)                                             
      Seminiferous Tubule, Mineralization, Focal                    1 (2%)                                                          
      Seminiferous Tubule, Mineralization,                                                                                          
          Multifocal                                                1 (2%)                                                          
      Seminiferous Tubule, Vacuolization                                                                                            
          Cytoplasmic, Diffuse                                                   2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)                                                
      Erythroid Cell, Hyperplasia, Diffuse                                       1 (2%)                                             
      Myeloid Cell, Hyperplasia, Diffuse               2 (4%)                                                                       
   Lymph Node                                         (50)         (50)         (49)                                                
      Axillary, Hyperplasia, Lymphoid, Multifocal      2 (4%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Inguinal, Hyperplasia, Diffuse, Lymphoid         1 (2%)                                                                       
      Inguinal, Hyperplasia, Lymphoid, Multifocal                   1 (2%)                                                          
      Inguinal, Pigmentation, Diffuse                  1 (2%)                                                                       
      Inguinal, Pigmentation, Focal                                 1 (2%)                                                          
      Inguinal, Pigmentation, Multifocal                                         1 (2%)                                             
      Renal, Hyperplasia, Lymphoid, Multifocal         1 (2%)                                                                       
   Lymph Node, Mesenteric                             (50)         (50)         (48)                                                
      Hematopoietic Cell Proliferation, Diffuse        3 (6%)       7 (14%)                                                         
      Hematopoietic Cell Proliferation, Focal          1 (2%)                                                                       
      Hyperplasia, Diffuse, Lymphoid                  12 (24%)      1 (2%)       1 (2%)                                             
      Hyperplasia, Diffuse, Re Cell                    2 (4%)                                                                       
      Hyperplasia, Focal, Lymphoid                     3 (6%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Lymphoid, Multifocal               11 (22%)      7 (14%)     10 (21%)                                            
      Infiltration Cellular, Diffuse, Plasma Cell      1 (2%)                                                                       
      Inflammation, Acute, Diffuse                     1 (2%)                                                                       
      Thrombosis                                                                 1 (2%)                                             
      Mediastinal, Hyperplasia, Lymphoid,                                                                                           
          Multifocal                                                             1 (2%)                                             
   Spleen                                             (50)         (50)         (48)                                                
      Hematopoietic Cell Proliferation, Diffuse        9 (18%)      3 (6%)       6 (13%)                                            
      Hyperplasia, Diffuse, Lymphoid                   4 (8%)       2 (4%)       2 (4%)                                             
      Hyperplasia, Focal, Lymphoid                     1 (2%)                                                                       
      Hyperplasia, Lymphoid, Multifocal               12 (24%)     11 (22%)     10 (21%)                                            
      Pigmentation, Diffuse                            1 (2%)                                                                       
   Thymus                                             (44)         (42)         (44)                                                
      Atrophy, Diffuse                                 6 (14%)      8 (19%)      5 (11%)                                            
      Cyst, Single                                     1 (2%)                                                                       
      Hyperplasia, Diffuse, Lymphoid                                             1 (2%)                                             
      Hyperplasia, Focal, Lymphoid                     1 (2%)                                                                       
      Mineralization, Multifocal                                    1 (2%)                                                          
      Mediastinum, Abscess, Focal                      1 (2%)                                                                       
      Mediastinum, Hemorrhage, Focal                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (5)          (4)          (6)                                                 
      Inflammation, Chronic, Multifocal                1 (20%)                                                                      
   Skin                                               (26)         (45)         (15)                                                
      Acanthosis, Focal                                4 (15%)      1 (2%)                                                          
      Acanthosis, Multifocal                           3 (12%)                   5 (33%)                                            
      Cyst Epithelial Inclusion, Single                1 (4%)                                                                       
      Hyperkeratosis, Focal                            3 (12%)      1 (2%)                                                          
      Hyperkeratosis, Multifocal                       2 (8%)                    1 (7%)                                             
      Inflammation, Acute, Multifocal                  1 (4%)                                                                       
      Inflammation, Chronic, Diffuse                   3 (12%)                   1 (7%)                                             
      Inflammation, Chronic, Focal                     2 (8%)       2 (4%)       1 (7%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inflammation, Chronic, Multifocal                2 (8%)                                                                       
      Ulcer, Focal                                     5 (19%)                                                                      
      Artery, Subcutaneous Tissue, Adventitia,                                                                                      
           Inflammation, Chronic, Focal                1 (4%)                                                                       
      Artery, Subcutaneous Tissue, Adventitia,                                                                                      
           Inflammation, Chronic, Multifocal           1 (4%)                                                                       
      Back, Ulcer, Focal                                                         1 (7%)                                             
      Hair Follicle, Atrophy, Diffuse                  3 (12%)                   1 (7%)                                             
      Hair Follicle, Atrophy, Focal                                              3 (20%)                                            
      Hair Follicle, Inflammation, Chronic,                                                                                         
          Multifocal                                   1 (4%)                                                                       
      Neck, Edema, Diffuse                                                       1 (7%)                                             
      Prepuce, Acanthosis, Diffuse                                               1 (7%)                                             
      Prepuce, Cyst Epithelial Inclusion, Focal        1 (4%)                                                                       
      Prepuce, Inflammation, Chronic, Diffuse                                    1 (7%)                                             
      Subcutaneous Tissue, Edema, Diffuse                           2 (4%)                                                          
      Subcutaneous Tissue, Head, Granuloma, Focal      1 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Bilateral, Thalamus, Mineralization,                                                                                          
          Multifocal                                  23 (46%)     20 (40%)     22 (44%)                                            
      Cerebellum, Hemorrhage, Multifocal                                         1 (2%)                                             
      Lateral Ventricle, Meninges, Abscess,                                                                                         
          Multifocal                                   1 (2%)                                                                       
      Olfactory Lobe, Mineralization, Focal                                      1 (2%)                                             
      Thalamus, Mineralization, Focal                  2 (4%)       1 (2%)                                                          
      Thalamus, Mineralization, Multifocal             5 (10%)      9 (18%)      7 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                                                       (1)                                                 
      Hemorrhage                                                                 1 (100%)                                           
   Lung                                               (50)         (50)         (50)                                                
      Congestion, Diffuse                                                        1 (2%)                                             
      Foreign Body                                                               1 (2%)                                             
      Hemorrhage, Focal                                1 (2%)       2 (4%)                                                          
      Hemorrhage, Multifocal                                        2 (4%)       3 (6%)                                             
      Thrombosis, Diffuse                              1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia                 2 (4%)                    1 (2%)                                             
      Alveolar Epithelium, Hypertrophy, Focal                       4 (8%)       1 (2%)                                             
      Alveolus, Foreign Body, Multifocal                                         1 (2%)                                             
      Peribronchial, Infiltration Cellular,                                                                                         
          Multifocal, Lymphocyte                      29 (58%)     32 (64%)     21 (42%)                                            
      Peribronchiolar, Infiltration Cellular,                                                                                       
          Multifocal, Lymphocyte                       1 (2%)                                                                       
      Perivascular, Infiltration Cellular,                                                                                          
          Multifocal, Lymphocyte                       4 (8%)       5 (10%)      1 (2%)                                             
      Pleura, Inflammation, Acute, Diffuse             1 (2%)                                                                       
      Pleura, Inflammation, Acute, Multifocal          1 (2%)                                                                       
      Pleura, Inflammation, Chronic, Focal                          1 (2%)                                                          
   Nose                                               (50)         (50)         (49)                                                
      Foreign Body                                    25 (50%)     23 (46%)     26 (53%)                                            
      Glands, Hyperplasia                              3 (6%)      42 (84%)     44 (90%)                                            
      Nasolacrimal Duct, Inflammation, Chronic,                                                                                     
           Diffuse                                                               1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Chronic,                                                                                     
           Focal                                       1 (2%)                                                                       
      Olfactory Epithelium, Atrophy                   11 (22%)     42 (84%)     44 (90%)                                            
      Turbinate, Congestion, Diffuse                                             1 (2%)                                             
      Turbinate, Exudate                               9 (18%)     10 (20%)      8 (16%)                                            
      Turbinate, Foreign Body                                                    1 (2%)                                             
      Turbinate, Hemorrhage, Diffuse                                             6 (12%)                                            
      Turbinate, Hemorrhage, Focal                                  1 (2%)                                                          
      Turbinate, Inflammation, Acute, Diffuse                                    1 (2%)                                             
      Turbinate, Inflammation, Acute, Focal                         1 (2%)       2 (4%)                                             
      Turbinate, Inflammation, Acute, Multifocal                    3 (6%)      27 (55%)                                            
      Turbinate, Inflammation, Chronic, Diffuse        1 (2%)       6 (12%)      1 (2%)                                             
      Turbinate, Inflammation, Chronic, Focal          6 (12%)      2 (4%)                                                          
      Turbinate, Inflammation, Chronic, Multifocal     9 (18%)      3 (6%)       6 (12%)                                            
   Trachea                                            (50)         (50)         (49)                                                
      Inflammation, Chronic, Diffuse                  10 (20%)      8 (16%)                                                         
      Inflammation, Chronic, Focal                     1 (2%)       2 (4%)                                                          
      Inflammation, Chronic, Multifocal               10 (20%)      5 (10%)     11 (22%)                                            
      Peritracheal Tissue, Foreign Body, Multifocal                              1 (2%)                                             
      Peritracheal Tissue, Hemorrhage, Diffuse                      1 (2%)       1 (2%)                                             
      Peritracheal Tissue, Hemorrhage, Multifocal                                1 (2%)                                             
      Peritracheal Tissue, Inflammation, Acute,                                                                                     
           Multifocal                                                            1 (2%)                                             
      Peritracheal Tissue, Inflammation, Chronic,                                                                                   
           Focal                                                                 1 (2%)                                             
      Peritracheal Tissue, Inflammation, Chronic,                                                                                   
           Multifocal                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)                                                
      Bacterium, Multifocal                            1 (2%)                                                                       
      Casts Protein, Diffuse                           1 (2%)                                                                       
      Cyst, Multiple                                                             1 (2%)                                             
      Cyst, Single                                     1 (2%)       4 (8%)       1 (2%)                                             
      Hydronephrosis                                   1 (2%)                                                                       
      Inflammation, Acute, Multifocal                  1 (2%)                                                                       
      Inflammation, Chronic, Focal                     2 (4%)       5 (10%)      7 (14%)                                            
      Inflammation, Chronic, Multifocal                3 (6%)       3 (6%)       3 (6%)                                             
      Bilateral, Cyst, Multiple                                                  1 (2%)                                             
      Bilateral, Inflammation, Acute, Focal            1 (2%)                                                                       
      Bilateral, Inflammation, Chronic, Focal          1 (2%)                                                                       
      Bilateral, Inflammation, Chronic, Multifocal    29 (58%)     25 (50%)     19 (39%)                                            
      Bilateral, Artery, Inflammation, Chronic,                                                                                     
           Multifocal                                  1 (2%)                                                                       
      Bilateral, Renal Tubule, Casts Protein,                                                                                       
          Multifocal                                   1 (2%)                                                                       
      Bilateral, Renal Tubule, Concretion,                                                                                          
          Multifocal                                   1 (2%)       2 (4%)                                                          
      Bilateral, Renal Tubule, Degeneration,                                                                                        
          Multifocal                                   1 (2%)       2 (4%)       1 (2%)                                             
      Bilateral, Renal Tubule, Regeneration,                                                                                        
          Multifocal                                   2 (4%)       2 (4%)       2 (4%)                                             
      Bilateral, Renal Tubule, Vacuolization                                                                                        
          Cytoplasmic, Multifocal                      1 (2%)                                                                       
      Interstitial Tissue, Inflammation, Chronic,                                                                                   
           Diffuse                                     1 (2%)                                                                       
      Renal Tubule, Casts Protein, Diffuse             1 (2%)                                                                       
      Renal Tubule, Concretion, Multifocal             1 (2%)                                                                       
      Renal Tubule, Degeneration, Focal                1 (2%)       4 (8%)       1 (2%)                                             
      Renal Tubule, Degeneration, Multifocal           2 (4%)                    1 (2%)                                             
      Renal Tubule, Regeneration, Focal                             2 (4%)       3 (6%)                                             
      Renal Tubule, Regeneration, Multifocal           2 (4%)       4 (8%)                                                          
      Renal Tubule, Vacuolization Cytoplasmic,                                                                                      
           Multifocal                                               1 (2%)                                                          
   Ureter                                             (1)                                                                           
      Dilatation                                       1 (100%)                                                                     
   Urethra                                            (1)                                                                           
      Mucosa, Inflammation, Acute, Diffuse             1 (100%)                                                                     
   Urinary Bladder                                    (50)         (47)         (48)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
NTP Experiment-Test: 05032-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              CARVONE                                          Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 19:21:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      375          750                                                    
                                                   CONTROL      MG/KG        MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Dilatation                                       1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Focal, Lymphocyte         3 (6%)       3 (6%)       3 (6%)                                             
      Infiltration Cellular, Multifocal, Lymphocyte   13 (26%)      6 (13%)      3 (6%)                                             
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia, Diffuse    1 (2%)                                                                       
      Transitional Epithelium, Vacuolization                                                                                        
          Cytoplasmic, Diffuse                         1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   19                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 132292-132292/132292


--multipart-boundary--