TR 381 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
CARVONE
NTP Experiment-Test: 05032-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/04/94
Route: GAVAGE Time: 19:21:15
Facility: International Research and Development Corp.
Chemical CAS #: 99490
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 23 9 4
Dead 13 10 7
Accident 2 1
Survivors
Moribund 1
Terminal Sacrifice 14 28 38
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (49) (49)
Perforation, Focal 1 (2%) 1 (2%)
Mucosa, Muscularis, Inflammation, Acute,
Diffuse 1 (2%)
Periesophageal Tissue, Abscess, Focal 1 (2%)
Periesophageal Tissue, Abscess, Multifocal 2 (4%)
Periesophageal Tissue, Inflammation, Chronic 1 (2%)
Gallbladder (31) (34) (42)
Infiltration Cellular, Diffuse, Lymphocyte 1 (3%) 1 (3%) 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 2 (6%) 2 (5%)
Infiltration Cellular, Multifocal, Lymphocyte 2 (6%) 1 (3%) 1 (2%)
Inflammation, Acute, Diffuse 1 (3%) 1 (2%)
Inflammation, Acute, Focal 3 (9%) 1 (2%)
Intestine Large, Cecum (46) (44) (46)
Ulcer, Diffuse 1 (2%)
Lymphoid Nodule, Hyperplasia, Focal, Lymphoid 1 (2%)
Lymphoid Nodule, Hyperplasia, Lymphoid,
Multifocal 1 (2%)
Wall, Abscess, Multifocal 1 (2%)
Intestine Large, Rectum (47) (45) (45)
Inflammation, Acute, Focal 5 (11%) 15 (33%) 22 (49%)
Intestine Small, Jejunum (41) (40) (47)
Peyer's Patch, Hyperplasia, Diffuse, Lymphoid 1 (2%)
Peyer's Patch, Hyperplasia, Focal, Lymphoid 2 (4%)
Peyer's Patch, Hyperplasia, Lymphoid,
Multifocal 1 (3%)
Liver (50) (50) (50)
Angiectasis, Multifocal 1 (2%)
Fatty Change, Diffuse 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 18 (36%) 12 (24%) 1 (2%)
Hypertrophy, Focal 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 3 (6%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Infiltration Cellular, Multifocal, Lymphocyte 2 (4%) 4 (8%) 4 (8%)
Inflammation, Acute, Multifocal 1 (2%) 2 (4%)
Bile Duct, Infiltration Cellular, Multifocal,
Lymphocyte 3 (6%) 4 (8%) 5 (10%)
Bile Duct, Mineralization, Multifocal 1 (2%)
Hepatocyte, Focal Cellular Change 1 (2%)
Serosa, Abscess, Focal 1 (2%)
Serosa, Inflammation, Acute, Focal 1 (2%)
Serosa, Inflammation, Acute, Multifocal 2 (4%)
Serosa, Inflammation, Chronic, Focal 1 (2%)
Mesentery (20) (12) (2)
Abscess, Focal 1 (5%)
Abscess, Multifocal 19 (95%) 8 (67%)
Cyst, Single 1 (8%)
Inflammation, Acute, Multifocal 1 (50%)
Inflammation, Granulomatous, Multifocal 1 (8%)
Pigmentation, Diffuse 1 (8%)
Fat, Necrosis, Multifocal 1 (50%)
Pancreas (49) (49) (49)
Abscess, Multifocal 3 (6%) 1 (2%)
Atrophy, Diffuse 1 (2%) 1 (2%)
Atrophy, Focal 1 (2%) 3 (6%)
Atrophy, Multifocal 2 (4%)
Inflammation, Acute, Diffuse 4 (8%) 1 (2%)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Acute, Multifocal 2 (4%)
Inflammation, Chronic, Diffuse 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 5 (10%) 2 (4%)
Inflammation, Chronic, Multifocal 4 (8%) 1 (2%) 1 (2%)
Necrosis, Focal 1 (2%)
Necrosis, Multifocal 1 (2%)
Duct, Cyst, Single 2 (4%)
Duct, Dilatation 1 (2%) 1 (2%)
Duct, Inflammation, Chronic, Focal 1 (2%) 2 (4%)
Duct, Inflammation, Chronic, Multifocal 1 (2%) 3 (6%)
Salivary Glands (49) (45) (50)
Infiltration Cellular, Focal, Lymphocyte 4 (8%) 5 (11%) 9 (18%)
Infiltration Cellular, Multifocal, Lymphocyte 11 (22%) 8 (18%) 17 (34%)
Stomach, Forestomach (47) (47) (49)
Abscess, Focal 1 (2%) 1 (2%) 1 (2%)
Abscess, Multifocal 1 (2%)
Acanthosis, Focal 5 (11%) 2 (4%) 7 (14%)
Acanthosis, Multifocal 1 (2%)
Cyst Epithelial Inclusion, Focal 1 (2%) 1 (2%)
Hyperkeratosis, Focal 1 (2%) 3 (6%) 1 (2%)
Hyperplasia, Basal Cell 1 (2%)
Inflammation, Acute, Focal 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic, Focal 5 (11%) 3 (6%) 1 (2%)
Stomach, Glandular (48) (49) (50)
Inflammation, Acute, Focal 1 (2%) 1 (2%) 1 (2%)
Inflammation, Acute, Multifocal 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (49) (50)
Aorta, Media, Mineralization, Diffuse 1 (2%)
Heart (50) (50) (50)
Artery, Inflammation, Chronic, Focal 1 (2%) 3 (6%)
Atrium Left, Bacterium, Focal 1 (2%)
Atrium Left, Thrombosis 1 (2%) 1 (2%)
Epicardium, Inflammation, Acute, Diffuse 1 (2%)
Epicardium, Inflammation, Acute, Focal 1 (2%)
Epicardium, Inflammation, Acute, Multifocal 3 (6%)
Epicardium, Inflammation, Chronic, Diffuse 1 (2%)
Epicardium, Inflammation, Chronic, Focal 2 (4%)
Epicardium, Inflammation, Chronic, Multifocal 1 (2%)
Myocardium, Inflammation, Acute, Diffuse 1 (2%)
Myocardium, Inflammation, Acute, Focal 1 (2%)
Myocardium, Inflammation, Chronic, Focal 2 (4%)
Myocardium, Inflammation, Chronic, Multifocal 1 (2%)
Pericardium, Inflammation, Chronic, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (49) (50)
Capsule, Inflammation, Chronic, Multifocal 1 (2%)
Adrenal Gland, Cortex (50) (49) (50)
Cyst, Multiple 1 (2%)
Cyst, Single 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation, Diffuse 2 (4%)
Hematopoietic Cell Proliferation, Focal 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 2 (4%) 1 (2%) 1 (2%)
Hypertrophy, Focal 1 (2%) 1 (2%)
Bilateral, Hematopoietic Cell Proliferation,
Diffuse 1 (2%) 1 (2%)
Bilateral, Hematopoietic Cell Proliferation,
Multifocal 9 (18%) 2 (4%)
Bilateral, Vacuolization Cytoplasmic, Diffuse 2 (4%) 1 (2%) 1 (2%)
Bilateral, Spindle Cell, Hyperplasia, Diffuse 32 (64%) 33 (67%) 39 (78%)
Bilateral, Spindle Cell, Hyperplasia,
Multifocal 16 (32%) 10 (20%) 7 (14%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Spindle Cell, Hyperplasia, Diffuse 1 (2%) 4 (8%) 3 (6%)
Spindle Cell, Hyperplasia, Multifocal 1 (2%) 1 (2%)
Adrenal Gland, Medulla (49) (48) (50)
Hematopoietic Cell Proliferation, Focal 1 (2%)
Pituitary Gland (46) (49) (48)
Hypertrophy, Focal 1 (2%) 1 (2%) 1 (2%)
Craniopharyngeal Duct, Cyst 1 (2%)
Thyroid Gland (49) (46) (50)
Granuloma, Focal 1 (2%)
Hyperplasia, Multifocal 1 (2%)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 1 (2%)
Ultimobranchial Cyst 13 (27%) 18 (39%) 4 (8%)
Follicle, Cyst 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (48) (48)
Abscess, Focal 4 (8%)
Abscess, Multifocal 16 (32%) 7 (15%)
Cyst, Multiple 1 (2%) 1 (2%)
Cyst, Single 7 (14%) 4 (8%) 10 (21%)
Mineralization, Focal 2 (4%)
Bilateral, Abscess, Multifocal 6 (12%) 2 (4%) 1 (2%)
Bilateral, Cyst, Multiple 2 (4%) 1 (2%) 1 (2%)
Germinal Epithelium, Hyperplasia, Focal 1 (2%)
Periovarian Tissue, Inflammation, Chronic,
Diffuse 1 (2%)
Oviduct (1)
Inflammation, Acute, Diffuse 1 (100%)
Uterus (50) (50) (50)
Abscess, Focal 1 (2%) 1 (2%)
Abscess, Multifocal 9 (18%) 2 (4%)
Dilatation 5 (10%) 7 (14%) 14 (28%)
Inflammation, Acute, Diffuse 3 (6%) 3 (6%)
Endometrium, Edema, Diffuse 1 (2%)
Endometrium, Hyperplasia, Cystic, Diffuse 14 (28%) 26 (52%) 27 (54%)
Endometrium, Hyperplasia, Cystic, Multifocal 1 (2%) 1 (2%) 1 (2%)
Lumen, Exudate 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Hypoplasia, Diffuse 1 (2%)
Myelofibrosis, Focal 2 (4%)
Myeloid Cell, Hyperplasia, Diffuse 6 (12%) 4 (8%) 1 (2%)
Lymph Node (47) (47) (48)
Bronchial, Abscess, Focal 1 (2%)
Bronchial, Hyperplasia, Diffuse, Lymphoid 1 (2%)
Bronchial, Infiltration Cellular, Diffuse,
Plasma Cell 1 (2%)
Iliac, Hyperplasia, Lymphoid, Multifocal 1 (2%)
Iliac, Infiltration Cellular, Diffuse,
Plasma Cell 4 (9%) 1 (2%)
Inguinal, Infiltration Cellular, Diffuse,
Plasma Cell 2 (4%)
Mediastinal, Abscess, Focal 1 (2%)
Mediastinal, Abscess, Multifocal 1 (2%)
Mediastinal, Hyperplasia, Diffuse, Lymphoid 1 (2%)
Mediastinal, Infiltration Cellular, Diffuse,
Plasma Cell 1 (2%)
Renal, Infiltration Cellular, Diffuse,
Plasma Cell 4 (9%) 1 (2%)
Lymph Node, Mandibular (7) (15)
Hyperplasia, Diffuse, Lymphoid 1 (14%)
Hyperplasia, Focal, Lymphoid 1 (7%)
Hyperplasia, Lymphoid, Multifocal 2 (29%) 8 (53%)
Infiltration Cellular, Diffuse, Plasma Cell 4 (57%) 7 (47%)
Sinus, Ectasia, Diffuse 1 (14%)
Lymph Node, Mesenteric (46) (47) (48)
Hematopoietic Cell Proliferation, Multifocal 1 (2%) 1 (2%)
Hyperplasia, Diffuse, Lymphoid 1 (2%) 1 (2%) 2 (4%)
Hyperplasia, Diffuse, Re Cell 7 (15%) 1 (2%) 1 (2%)
Hyperplasia, Focal, Lymphoid 2 (4%)
Hyperplasia, Lymphoid, Multifocal 2 (4%) 3 (6%) 14 (29%)
Infiltration Cellular, Diffuse, Plasma Cell 2 (4%) 1 (2%)
Inflammation, Acute, Focal 1 (2%)
Necrosis, Caseous, Diffuse 1 (2%)
Spleen (50) (49) (50)
Depletion Lymphoid, Diffuse 1 (2%)
Hematopoietic Cell Proliferation, Diffuse 32 (64%) 18 (37%) 7 (14%)
Hyperplasia, Diffuse, Lymphoid 4 (8%) 3 (6%) 16 (32%)
Hyperplasia, Lymphoid, Multifocal 1 (2%) 2 (4%) 3 (6%)
Hyperplasia, Multifocal, Re Cell 1 (2%)
Pigmentation, Diffuse 6 (12%) 3 (6%) 3 (6%)
Artery, Trabecula, Amyloid Deposition,
Multifocal 1 (2%)
Capsule, Inflammation, Acute, Diffuse 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Capsule, Inflammation, Acute, Multifocal 1 (2%)
Capsule, Inflammation, Chronic, Diffuse 1 (2%)
Capsule, Inflammation, Chronic, Focal 2 (4%)
Thymus (35) (42) (46)
Abscess, Focal 1 (2%)
Abscess, Multifocal 1 (3%)
Atrophy, Diffuse 17 (49%) 13 (31%) 6 (13%)
Hyperplasia, Focal, Lymphoid 1 (2%) 2 (4%)
Hyperplasia, Focal, Re Cell 1 (2%)
Hyperplasia, Lymphoid, Multifocal 2 (6%)
Mediastinum, Abscess, Focal 1 (3%)
Mediastinum, Abscess, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (46) (42)
Hyperplasia, Diffuse 16 (33%) 8 (17%) 3 (7%)
Inflammation, Acute 1 (2%)
Skin (16) (34) (14)
Acanthosis, Diffuse 2 (6%) 1 (7%)
Acanthosis, Focal 1 (6%) 2 (14%)
Acanthosis, Multifocal 1 (6%) 3 (9%) 8 (57%)
Hyperkeratosis, Diffuse 1 (3%) 1 (7%)
Hyperkeratosis, Focal 1 (3%)
Hyperkeratosis, Multifocal 2 (6%)
Inflammation, Acute, Multifocal 1 (7%)
Inflammation, Chronic, Diffuse 5 (15%) 2 (14%)
Inflammation, Chronic, Focal 1 (3%)
Inflammation, Chronic, Multifocal 1 (3%) 1 (7%)
Ulcer, Focal 1 (7%)
Back, Subcutaneous Tissue, Abscess, Focal 1 (6%)
Hair Follicle, Acanthosis, Diffuse 1 (7%)
Hair Follicle, Atrophy, Diffuse 3 (19%) 3 (9%) 6 (43%)
Hair Follicle, Atrophy, Focal 1 (6%)
Hair Follicle, Atrophy, Multifocal 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Femur, Fibrous Osteodystrophy, Diffuse 3 (6%)
Femur, Fracture Healed 1 (2%)
Skeletal Muscle (1) (1) (2)
Inflammation, Acute, Diffuse 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50)
Bilateral, Thalamus, Mineralization,
Multifocal 12 (24%) 17 (35%) 15 (30%)
Meninges, Abscess, Focal 1 (2%)
Meninges, Inflammation, Acute, Focal 1 (2%)
Meninges, Cerebrum, Abscess, Multifocal 1 (2%)
Thalamus, Hemorrhage, Multifocal 1 (2%)
Thalamus, Mineralization, Focal 3 (6%) 3 (6%) 4 (8%)
Thalamus, Mineralization, Multifocal 5 (10%) 6 (12%) 6 (12%)
Ventricle, Abscess, Multifocal 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Abscess, Multifocal 1 (2%) 2 (4%)
Bacterium, Multifocal 1 (2%)
Congestion, Multifocal 1 (2%)
Hemorrhage, Diffuse 1 (2%)
Hemorrhage, Focal 2 (4%)
Hemorrhage, Multifocal 2 (4%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%)
Alveolus, Inflammation, Acute, Focal 1 (2%)
Artery, Adventitia, Inflammation, Chronic,
Multifocal 1 (2%)
Artery, Media, Hypertrophy, Multifocal 4 (8%)
Peribronchial, Infiltration Cellular,
Diffuse, Lymphocyte 1 (2%) 1 (2%)
Peribronchial, Infiltration Cellular,
Multifocal, Lymphocyte 30 (60%) 28 (56%) 35 (70%)
Peribronchiolar, Infiltration Cellular,
Multifocal, Lymphocyte 2 (4%) 2 (4%)
Perivascular, Infiltration Cellular, Diffuse,
Lymphocyte 1 (2%) 1 (2%)
Perivascular, Infiltration Cellular,
Multifocal, Lymphocyte 16 (32%) 23 (46%) 8 (16%)
Pleura, Foreign Body, Focal 1 (2%) 1 (2%)
Pleura, Granuloma, Focal 1 (2%)
Pleura, Inflammation, Acute, Diffuse 1 (2%)
Pleura, Inflammation, Acute, Multifocal 1 (2%)
Pleura, Inflammation, Chronic, Diffuse 1 (2%)
Nose (49) (49) (50)
Foreign Body 35 (71%) 35 (71%) 33 (66%)
Hyperplasia, Focal, Lymphoid 1 (2%)
Glands, Hyperplasia 19 (39%) 45 (92%) 49 (98%)
Nasolacrimal Duct, Exudate, Diffuse 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Olfactory Epithelium, Atrophy 25 (51%) 46 (94%) 49 (98%)
Turbinate, Exudate 15 (31%) 22 (45%) 17 (34%)
Turbinate, Fungus, Focal 1 (2%)
Turbinate, Fungus, Multifocal 1 (2%)
Turbinate, Hemorrhage, Diffuse 2 (4%)
Turbinate, Hemorrhage, Focal 1 (2%)
Turbinate, Hemorrhage, Multifocal 1 (2%)
Turbinate, Inflammation, Acute, Diffuse 2 (4%) 2 (4%)
Turbinate, Inflammation, Acute, Focal 1 (2%)
Turbinate, Inflammation, Acute, Multifocal 5 (10%) 22 (45%) 39 (78%)
Turbinate, Inflammation, Chronic, Diffuse 1 (2%) 10 (20%) 3 (6%)
Turbinate, Inflammation, Chronic, Focal 1 (2%) 4 (8%) 2 (4%)
Turbinate, Inflammation, Chronic, Multifocal 29 (59%) 17 (35%) 16 (32%)
Turbinate, Ulcer, Focal 1 (2%)
Trachea (49) (50) (50)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Chronic, Diffuse 3 (6%) 3 (6%) 1 (2%)
Inflammation, Chronic, Focal 2 (4%) 5 (10%) 1 (2%)
Inflammation, Chronic, Multifocal 6 (12%) 7 (14%) 10 (20%)
Peritracheal Tissue, Abscess, Multifocal 1 (2%)
Peritracheal Tissue, Foreign Body, Focal 1 (2%)
Peritracheal Tissue, Hemorrhage, Focal 1 (2%)
Peritracheal Tissue, Inflammation, Acute,
Focal 1 (2%)
Peritracheal Tissue, Inflammation, Chronic,
Diffuse 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Cyst, Multiple 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 2 (4%) 4 (8%)
Inflammation, Chronic, Multifocal 2 (4%) 10 (20%) 7 (14%)
Bilateral, Abscess, Multifocal 1 (2%)
Bilateral, Glomerulosclerosis, Diffuse 2 (4%) 1 (2%)
Bilateral, Hematopoietic Cell Proliferation,
Diffuse 1 (2%)
Bilateral, Inflammation, Chronic, Diffuse 1 (2%)
Bilateral, Inflammation, Chronic, Multifocal 33 (66%) 21 (42%) 21 (42%)
Bilateral, Cortex, Abscess, Multifocal 1 (2%)
Bilateral, Pelvis, Bacterium, Multifocal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Bilateral, Renal Tubule, Bacterium,
Multifocal 1 (2%)
Bilateral, Renal Tubule, Casts Protein,
Multifocal 1 (2%)
Bilateral, Renal Tubule, Mineralization,
Multifocal 1 (2%)
Bilateral, Renal Tubule, Pigmentation,
Multifocal 2 (4%)
Bilateral, Renal Tubule, Regeneration,
Multifocal 1 (2%)
Capsule, Interstitial Tissue, Inflammation,
Chronic 1 (2%)
Glomerulus, Renal Tubule, Amyloid Deposition,
Diffuse 1 (2%)
Interstitial Tissue, Renal Tubule,
Pigmentation, Multifocal 1 (2%)
Left, Hydronephrosis 1 (2%)
Pelvis, Bacterium, Focal 1 (2%)
Pelvis, Bacterium, Multifocal 1 (2%) 1 (2%) 1 (2%)
Pelvis, Concretion, Multifocal 1 (2%)
Renal Tubule, Bacterium, Multifocal 1 (2%)
Renal Tubule, Casts Protein, Multifocal 1 (2%)
Renal Tubule, Degeneration, Focal 3 (6%)
Renal Tubule, Degeneration, Multifocal 1 (2%)
Renal Tubule, Regeneration, Focal 1 (2%) 1 (2%)
Renal Tubule, Regeneration, Multifocal 2 (4%)
Ureter (1)
Dilatation 1 (100%)
Urinary Bladder (46) (46) (48)
Abscess, Focal 1 (2%) 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 4 (9%) 6 (13%) 5 (10%)
Infiltration Cellular, Multifocal, Lymphocyte 16 (35%) 22 (48%) 19 (40%)
Serosa, Inflammation, Chronic, Multifocal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 6 6 7
Moribund 7 2 3
Accident 4
Survivors
Terminal Sacrifice 37 42 36
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (49)
Perforation, Focal 1 (2%)
Periesophageal Tissue, Hemorrhage, Focal 1 (2%)
Periesophageal Tissue, Inflammation, Acute,
Diffuse 1 (2%)
Gallbladder (38) (36) (43)
Infiltration Cellular, Diffuse, Lymphocyte 4 (11%) 2 (6%) 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 1 (3%) 3 (8%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (3%) 1 (3%)
Inflammation, Acute, Diffuse 1 (3%) 4 (11%)
Inflammation, Acute, Focal 1 (2%)
Intestine Large, Cecum (50) (46) (49)
Lymphoid Nodule, Hyperplasia, Focal, Lymphoid 1 (2%)
Lymphoid Nodule, Hyperplasia, Lymphoid,
Multifocal 1 (2%)
Intestine Large, Rectum (48) (45) (44)
Inflammation, Acute, Focal 19 (40%) 15 (33%) 18 (41%)
Intestine Small, Duodenum (48) (47) (46)
Peyer's Patch, Hyperplasia, Lymphoid,
Multifocal 1 (2%)
Intestine Small, Jejunum (48) (48) (48)
Peyer's Patch, Hyperplasia, Focal, Lymphoid 1 (2%) 2 (4%)
Liver (50) (50) (49)
Basophilic Focus 1 (2%)
Cyst, Multiple 1 (2%)
Fatty Change, Multifocal 1 (2%) 1 (2%)
Infarct, Focal 2 (4%) 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 3 (6%)
Inflammation, Acute, Focal 1 (2%)
Necrosis, Coagulative, Diffuse 1 (2%)
Necrosis, Coagulative, Multifocal 2 (4%)
Bile Duct, Infiltration Cellular, Multifocal,
Lymphocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (1)
Inflammation, Acute, Diffuse 1 (100%)
Pancreas (50) (50) (48)
Abscess, Focal 1 (2%)
Atrophy, Focal 2 (4%) 3 (6%) 2 (4%)
Inflammation, Chronic, Focal 1 (2%) 7 (14%)
Inflammation, Chronic, Multifocal 2 (4%) 2 (4%)
Necrosis, Focal 1 (2%)
Vacuolization Cytoplasmic, Multifocal 1 (2%) 1 (2%)
Artery, Media, Mineralization, Multifocal 1 (2%)
Duct, Inflammation, Chronic, Focal 1 (2%)
Salivary Glands (50) (50) (50)
Infiltration Cellular, Focal, Lymphocyte 5 (10%) 10 (20%) 7 (14%)
Infiltration Cellular, Multifocal, Lymphocyte 17 (34%) 25 (50%) 11 (22%)
Stomach, Forestomach (48) (48) (47)
Abscess, Focal 4 (8%) 3 (6%)
Abscess, Multifocal 1 (2%) 3 (6%)
Acanthosis, Focal 2 (4%) 3 (6%) 5 (11%)
Acanthosis, Multifocal 2 (4%) 2 (4%) 6 (13%)
Cyst Epithelial Inclusion, Focal 1 (2%) 1 (2%)
Hyperkeratosis, Focal 2 (4%)
Inflammation, Acute, Focal 1 (2%) 1 (2%)
Inflammation, Acute, Multifocal 1 (2%)
Inflammation, Chronic, Focal 2 (4%) 6 (13%)
Inflammation, Chronic, Multifocal 1 (2%) 1 (2%)
Serosa, Inflammation, Acute, Diffuse 1 (2%)
Stomach, Glandular (49) (49) (48)
Inflammation, Acute, Focal 2 (4%)
Inflammation, Chronic, Focal 1 (2%)
Artery, Adventitia, Inflammation, Chronic,
Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (49) (50) (50)
Mesenteric Artery, Aorta, Adventitia,
Inflammation, Chronic, Multifocal 1 (2%)
Mesenteric Artery, Aorta, Media, Hypertrophy,
Multifocal 1 (2%)
Mesenteric Artery, Renal Artery, Adventitia,
Inflammation, Chronic, Multifocal 1 (2%)
Mesenteric Artery, Renal Artery, Media,
Hypertrophy, Diffuse 1 (2%)
Heart (50) (50) (50)
Artery, Inflammation, Chronic, Diffuse 2 (4%) 1 (2%)
Endocardium, Inflammation, Acute, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Endocardium, Inflammation, Chronic, Focal 1 (2%)
Epicardium, Inflammation, Acute, Diffuse 2 (4%) 1 (2%)
Epicardium, Inflammation, Acute, Focal 1 (2%) 2 (4%)
Ventricle Left, Myocardium, Hemorrhage, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50)
Hypertrophy, Focal 1 (2%) 3 (6%) 2 (4%)
Bilateral, Hypertrophy, Multifocal 1 (2%)
Bilateral, Spindle Cell, Hyperplasia, Diffuse 1 (2%)
Bilateral, Spindle Cell, Hyperplasia, Focal 1 (2%)
Bilateral, Spindle Cell, Hyperplasia,
Multifocal 25 (50%) 30 (60%) 23 (46%)
Spindle Cell, Hyperplasia, Diffuse 1 (2%)
Spindle Cell, Hyperplasia, Focal 9 (18%) 8 (16%) 5 (10%)
Spindle Cell, Hyperplasia, Multifocal 11 (22%) 6 (12%) 4 (8%)
Adrenal Gland, Medulla (48) (49) (48)
Hyperplasia, Focal 1 (2%) 1 (2%)
Islets, Pancreatic (50) (47) (49)
Vacuolization Cytoplasmic, Diffuse 1 (2%)
Parathyroid Gland (27) (27) (26)
Cyst, Single 1 (4%)
Infiltration Cellular, Focal, Lymphocyte 1 (4%)
Pituitary Gland (40) (48) (48)
Hypertrophy, Focal 1 (3%)
Craniopharyngeal Duct, Cyst 1 (3%) 1 (2%)
Thyroid Gland (50) (50) (49)
Hyperplasia, Cystic, Focal 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 1 (2%) 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Ultimobranchial Cyst 5 (10%) 9 (18%) 7 (14%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50)
Atypia Cellular, Multifocal 1 (2%) 1 (2%)
Granuloma Sperm, Focal 1 (2%)
Inflammation, Chronic, Focal 4 (8%) 2 (4%) 2 (4%)
Inflammation, Chronic, Multifocal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Spermatocele 1 (2%)
Vacuolization Cytoplasmic, Diffuse 1 (2%) 2 (4%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Bilateral, Atypia Cellular, Multifocal 4 (8%)
Bilateral, Inflammation, Chronic, Multifocal 1 (2%)
Bilateral, Vacuolization Cytoplasmic, Diffuse 1 (2%) 1 (2%)
Bilateral, Vacuolization Cytoplasmic,
Multifocal 1 (2%) 1 (2%)
Serosa, Inflammation, Acute, Diffuse 1 (2%)
Penis (1)
Inflammation, Focal 1 (100%)
Preputial Gland (10) (4) (3)
Abscess, Focal 4 (40%) 1 (33%)
Abscess, Multifocal 1 (10%) 1 (25%)
Dilatation 1 (10%) 1 (25%) 1 (33%)
Inflammation, Chronic, Diffuse 3 (30%) 1 (25%) 1 (33%)
Inflammation, Chronic, Multifocal 1 (10%)
Bilateral, Abscess, Multifocal 2 (50%)
Bilateral, Dilatation 1 (10%)
Prostate (49) (49) (49)
Abscess, Multifocal 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 3 (6%) 4 (8%) 2 (4%)
Infiltration Cellular, Multifocal, Lymphocyte 2 (4%) 1 (2%) 1 (2%)
Inflammation, Acute, Diffuse 2 (4%)
Seminal Vesicle (1)
Abscess, Multifocal 1 (100%)
Testes (50) (50) (50)
Bilateral, Seminiferous Tubule, Degeneration,
Diffuse 1 (2%)
Bilateral, Seminiferous Tubule,
Vacuolization Cytoplasmic, Diffuse 2 (4%) 3 (6%) 1 (2%)
Seminiferous Tubule, Degeneration, Diffuse 1 (2%) 1 (2%) 1 (2%)
Seminiferous Tubule, Degeneration, Focal 1 (2%) 1 (2%) 1 (2%)
Seminiferous Tubule, Mineralization, Focal 1 (2%)
Seminiferous Tubule, Mineralization,
Multifocal 1 (2%)
Seminiferous Tubule, Vacuolization
Cytoplasmic, Diffuse 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49)
Erythroid Cell, Hyperplasia, Diffuse 1 (2%)
Myeloid Cell, Hyperplasia, Diffuse 2 (4%)
Lymph Node (50) (50) (49)
Axillary, Hyperplasia, Lymphoid, Multifocal 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Inguinal, Hyperplasia, Diffuse, Lymphoid 1 (2%)
Inguinal, Hyperplasia, Lymphoid, Multifocal 1 (2%)
Inguinal, Pigmentation, Diffuse 1 (2%)
Inguinal, Pigmentation, Focal 1 (2%)
Inguinal, Pigmentation, Multifocal 1 (2%)
Renal, Hyperplasia, Lymphoid, Multifocal 1 (2%)
Lymph Node, Mesenteric (50) (50) (48)
Hematopoietic Cell Proliferation, Diffuse 3 (6%) 7 (14%)
Hematopoietic Cell Proliferation, Focal 1 (2%)
Hyperplasia, Diffuse, Lymphoid 12 (24%) 1 (2%) 1 (2%)
Hyperplasia, Diffuse, Re Cell 2 (4%)
Hyperplasia, Focal, Lymphoid 3 (6%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid, Multifocal 11 (22%) 7 (14%) 10 (21%)
Infiltration Cellular, Diffuse, Plasma Cell 1 (2%)
Inflammation, Acute, Diffuse 1 (2%)
Thrombosis 1 (2%)
Mediastinal, Hyperplasia, Lymphoid,
Multifocal 1 (2%)
Spleen (50) (50) (48)
Hematopoietic Cell Proliferation, Diffuse 9 (18%) 3 (6%) 6 (13%)
Hyperplasia, Diffuse, Lymphoid 4 (8%) 2 (4%) 2 (4%)
Hyperplasia, Focal, Lymphoid 1 (2%)
Hyperplasia, Lymphoid, Multifocal 12 (24%) 11 (22%) 10 (21%)
Pigmentation, Diffuse 1 (2%)
Thymus (44) (42) (44)
Atrophy, Diffuse 6 (14%) 8 (19%) 5 (11%)
Cyst, Single 1 (2%)
Hyperplasia, Diffuse, Lymphoid 1 (2%)
Hyperplasia, Focal, Lymphoid 1 (2%)
Mineralization, Multifocal 1 (2%)
Mediastinum, Abscess, Focal 1 (2%)
Mediastinum, Hemorrhage, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (5) (4) (6)
Inflammation, Chronic, Multifocal 1 (20%)
Skin (26) (45) (15)
Acanthosis, Focal 4 (15%) 1 (2%)
Acanthosis, Multifocal 3 (12%) 5 (33%)
Cyst Epithelial Inclusion, Single 1 (4%)
Hyperkeratosis, Focal 3 (12%) 1 (2%)
Hyperkeratosis, Multifocal 2 (8%) 1 (7%)
Inflammation, Acute, Multifocal 1 (4%)
Inflammation, Chronic, Diffuse 3 (12%) 1 (7%)
Inflammation, Chronic, Focal 2 (8%) 2 (4%) 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inflammation, Chronic, Multifocal 2 (8%)
Ulcer, Focal 5 (19%)
Artery, Subcutaneous Tissue, Adventitia,
Inflammation, Chronic, Focal 1 (4%)
Artery, Subcutaneous Tissue, Adventitia,
Inflammation, Chronic, Multifocal 1 (4%)
Back, Ulcer, Focal 1 (7%)
Hair Follicle, Atrophy, Diffuse 3 (12%) 1 (7%)
Hair Follicle, Atrophy, Focal 3 (20%)
Hair Follicle, Inflammation, Chronic,
Multifocal 1 (4%)
Neck, Edema, Diffuse 1 (7%)
Prepuce, Acanthosis, Diffuse 1 (7%)
Prepuce, Cyst Epithelial Inclusion, Focal 1 (4%)
Prepuce, Inflammation, Chronic, Diffuse 1 (7%)
Subcutaneous Tissue, Edema, Diffuse 2 (4%)
Subcutaneous Tissue, Head, Granuloma, Focal 1 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Bilateral, Thalamus, Mineralization,
Multifocal 23 (46%) 20 (40%) 22 (44%)
Cerebellum, Hemorrhage, Multifocal 1 (2%)
Lateral Ventricle, Meninges, Abscess,
Multifocal 1 (2%)
Olfactory Lobe, Mineralization, Focal 1 (2%)
Thalamus, Mineralization, Focal 2 (4%) 1 (2%)
Thalamus, Mineralization, Multifocal 5 (10%) 9 (18%) 7 (14%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (1)
Hemorrhage 1 (100%)
Lung (50) (50) (50)
Congestion, Diffuse 1 (2%)
Foreign Body 1 (2%)
Hemorrhage, Focal 1 (2%) 2 (4%)
Hemorrhage, Multifocal 2 (4%) 3 (6%)
Thrombosis, Diffuse 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolar Epithelium, Hyperplasia 2 (4%) 1 (2%)
Alveolar Epithelium, Hypertrophy, Focal 4 (8%) 1 (2%)
Alveolus, Foreign Body, Multifocal 1 (2%)
Peribronchial, Infiltration Cellular,
Multifocal, Lymphocyte 29 (58%) 32 (64%) 21 (42%)
Peribronchiolar, Infiltration Cellular,
Multifocal, Lymphocyte 1 (2%)
Perivascular, Infiltration Cellular,
Multifocal, Lymphocyte 4 (8%) 5 (10%) 1 (2%)
Pleura, Inflammation, Acute, Diffuse 1 (2%)
Pleura, Inflammation, Acute, Multifocal 1 (2%)
Pleura, Inflammation, Chronic, Focal 1 (2%)
Nose (50) (50) (49)
Foreign Body 25 (50%) 23 (46%) 26 (53%)
Glands, Hyperplasia 3 (6%) 42 (84%) 44 (90%)
Nasolacrimal Duct, Inflammation, Chronic,
Diffuse 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic,
Focal 1 (2%)
Olfactory Epithelium, Atrophy 11 (22%) 42 (84%) 44 (90%)
Turbinate, Congestion, Diffuse 1 (2%)
Turbinate, Exudate 9 (18%) 10 (20%) 8 (16%)
Turbinate, Foreign Body 1 (2%)
Turbinate, Hemorrhage, Diffuse 6 (12%)
Turbinate, Hemorrhage, Focal 1 (2%)
Turbinate, Inflammation, Acute, Diffuse 1 (2%)
Turbinate, Inflammation, Acute, Focal 1 (2%) 2 (4%)
Turbinate, Inflammation, Acute, Multifocal 3 (6%) 27 (55%)
Turbinate, Inflammation, Chronic, Diffuse 1 (2%) 6 (12%) 1 (2%)
Turbinate, Inflammation, Chronic, Focal 6 (12%) 2 (4%)
Turbinate, Inflammation, Chronic, Multifocal 9 (18%) 3 (6%) 6 (12%)
Trachea (50) (50) (49)
Inflammation, Chronic, Diffuse 10 (20%) 8 (16%)
Inflammation, Chronic, Focal 1 (2%) 2 (4%)
Inflammation, Chronic, Multifocal 10 (20%) 5 (10%) 11 (22%)
Peritracheal Tissue, Foreign Body, Multifocal 1 (2%)
Peritracheal Tissue, Hemorrhage, Diffuse 1 (2%) 1 (2%)
Peritracheal Tissue, Hemorrhage, Multifocal 1 (2%)
Peritracheal Tissue, Inflammation, Acute,
Multifocal 1 (2%)
Peritracheal Tissue, Inflammation, Chronic,
Focal 1 (2%)
Peritracheal Tissue, Inflammation, Chronic,
Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49)
Bacterium, Multifocal 1 (2%)
Casts Protein, Diffuse 1 (2%)
Cyst, Multiple 1 (2%)
Cyst, Single 1 (2%) 4 (8%) 1 (2%)
Hydronephrosis 1 (2%)
Inflammation, Acute, Multifocal 1 (2%)
Inflammation, Chronic, Focal 2 (4%) 5 (10%) 7 (14%)
Inflammation, Chronic, Multifocal 3 (6%) 3 (6%) 3 (6%)
Bilateral, Cyst, Multiple 1 (2%)
Bilateral, Inflammation, Acute, Focal 1 (2%)
Bilateral, Inflammation, Chronic, Focal 1 (2%)
Bilateral, Inflammation, Chronic, Multifocal 29 (58%) 25 (50%) 19 (39%)
Bilateral, Artery, Inflammation, Chronic,
Multifocal 1 (2%)
Bilateral, Renal Tubule, Casts Protein,
Multifocal 1 (2%)
Bilateral, Renal Tubule, Concretion,
Multifocal 1 (2%) 2 (4%)
Bilateral, Renal Tubule, Degeneration,
Multifocal 1 (2%) 2 (4%) 1 (2%)
Bilateral, Renal Tubule, Regeneration,
Multifocal 2 (4%) 2 (4%) 2 (4%)
Bilateral, Renal Tubule, Vacuolization
Cytoplasmic, Multifocal 1 (2%)
Interstitial Tissue, Inflammation, Chronic,
Diffuse 1 (2%)
Renal Tubule, Casts Protein, Diffuse 1 (2%)
Renal Tubule, Concretion, Multifocal 1 (2%)
Renal Tubule, Degeneration, Focal 1 (2%) 4 (8%) 1 (2%)
Renal Tubule, Degeneration, Multifocal 2 (4%) 1 (2%)
Renal Tubule, Regeneration, Focal 2 (4%) 3 (6%)
Renal Tubule, Regeneration, Multifocal 2 (4%) 4 (8%)
Renal Tubule, Vacuolization Cytoplasmic,
Multifocal 1 (2%)
Ureter (1)
Dilatation 1 (100%)
Urethra (1)
Mucosa, Inflammation, Acute, Diffuse 1 (100%)
Urinary Bladder (50) (47) (48)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Dilatation 1 (2%) 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 3 (6%) 3 (6%) 3 (6%)
Infiltration Cellular, Multifocal, Lymphocyte 13 (26%) 6 (13%) 3 (6%)
Inflammation, Acute, Focal 1 (2%)
Transitional Epithelium, Hyperplasia, Diffuse 1 (2%)
Transitional Epithelium, Vacuolization
Cytoplasmic, Diffuse 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
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