TR 381 Mouse Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
CARVONE
NTP Experiment-Test: 05032-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/04/94
Route: GAVAGE Time: 19:21:15
Facility: International Research and Development Corp.
Chemical CAS #: 99490
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 23 9 4
Dead 13 10 7
Accident 2 1
Survivors
Moribund 1
Terminal Sacrifice 14 28 38
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (31) (34) (42)
Intestine Large, Cecum (46) (44) (46)
Intestine Large, Colon (48) (47) (47)
Intestine Small, Jejunum (41) (40) (47)
Liver (50) (50) (50)
Hepatocellular Carcinoma 2 (4%) 1 (2%)
Hepatocellular Adenoma 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Mesentery (20) (12) (2)
Sarcoma, Metastatic, Skin 1 (8%)
Fat, Sarcoma, Metastatic, Skeletal Muscle 1 (50%)
Pancreas (49) (49) (49)
Parenchyma, Sarcoma, Metastatic, Skin 1 (2%)
Parenchyma, Sarcoma, Metastatic, Skeletal
Muscle 1 (2%)
Stomach, Forestomach (47) (47) (49)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 3 (6%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (49) (50)
Capsule, Sarcoma, Metastatic, Skin 1 (2%)
Adrenal Gland, Cortex (50) (49) (50)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Page 2
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pituitary Gland (46) (49) (48)
Adenoma 1 (2%) 1 (2%)
Pars Distalis, Adenoma 1 (2%)
Thyroid Gland (49) (46) (50)
Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (48) (48)
Adenoma, Papillary 1 (2%)
Uterus (50) (50) (50)
Leiomyosarcoma 1 (2%)
Polyp 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (47) (47) (48)
Mediastinal, Sarcoma 1 (2%)
Pancreatic, Leiomyosarcoma, Metastatic,
Uterus 1 (2%)
Lymph Node, Mesenteric (46) (47) (48)
Sarcoma, Metastatic 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Spleen (50) (49) (50)
Capsule, Sarcoma, Metastatic, Skin 1 (2%)
Capsule, Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Thymus (35) (42) (46)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (46) (42)
Adenocarcinoma 1 (2%) 1 (2%)
Skin (16) (34) (14)
Subcutaneous Tissue, Sarcoma 1 (3%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1) (2)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (100%)
Back, Sarcoma 1 (50%)
Diaphragm, Sarcoma, Metastatic, Skeletal
Muscle 1 (50%)
Thigh, Sarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 6 (12%) 3 (6%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Parenchyma, Sarcoma, Metastatic, Skeletal
Muscle 1 (2%)
Trachea (49) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2)
Adenoma 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Bilateral, Capsule, Sarcoma, Metastatic, Skin 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (46) (46) (48)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Lymphocytic 1 (2%)
Lymphoma Malignant Mixed 1 (2%) 4 (8%) 4 (8%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 9 14 14
Total Primary Neoplasms 9 18 18
Total Animals with Benign Neoplasms 6 8 7
Total Benign Neoplasms 6 10 8
Total Animals with Malignant Neoplasms 3 8 8
Total Malignant Neoplasms 3 8 10
Total Animals with Metastatic Neoplasms 2 2
Total Metastatic Neoplasm 8 9
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 6 6 7
Moribund 7 2 3
Accident 4
Survivors
Terminal Sacrifice 37 42 36
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (49)
Periesophageal Tissue, Alveolar/Bronchiolar
Carcinoma, Metastatic, Lung 1 (2%)
Gallbladder (38) (36) (43)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Intestine Large, Cecum (50) (46) (49)
Intestine Small, Ileum (49) (49) (48)
Intestine Small, Jejunum (48) (48) (48)
Liver (50) (50) (49)
Hepatocellular Carcinoma 5 (10%) 3 (6%) 3 (6%)
Hepatocellular Adenoma 2 (4%) 4 (8%) 4 (8%)
Pancreas (50) (50) (48)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Sarcoma, Metastatic, Lymph Node 1 (2%)
Salivary Glands (50) (50) (50)
Stomach, Forestomach (48) (48) (47)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Stomach, Glandular (49) (49) (48)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Epicardium, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Medulla (48) (49) (48)
Pheochromocytoma Benign 1 (2%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Pituitary Gland (40) (48) (48)
Thyroid Gland (50) (50) (49)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49)
Lymph Node (50) (50) (49)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Lymph Node, Mesenteric (50) (50) (48)
Hemangioma 1 (2%)
Sarcoma 1 (2%)
Spleen (50) (50) (48)
Hemangiosarcoma 1 (2%)
Thymus (44) (42) (44)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (26) (45) (15)
Back, Subcutaneous Tissue, Fibroma 2 (8%) 1 (7%)
Prepuce, Squamous Cell Carcinoma 1 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (4%)
Subcutaneous Tissue, Hemangioma 1 (4%)
Subcutaneous Tissue, Neurofibrosarcoma 2 (8%) 1 (2%)
Subcutaneous Tissue, Sarcoma 4 (15%) 2 (13%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Fibrosarcoma, Metastatic, Skin 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 7 (14%) 4 (8%) 5 (10%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Nose (50) (50) (49)
Trachea (50) (50) (49)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (2) (1)
Adenoma 1 (100%) 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Glomerulus, Carcinoma, Metastatic, Uncertain
Primary Site 1 (2%)
Renal Tubule, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%)
Lymphoma Malignant Mixed 4 (8%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 8
NTP Experiment-Test: 05032-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC CARVONE Date: 09/04/94
Route: GAVAGE Time: 19:21:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 375 750
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 27 15 16
Total Primary Neoplasms 38 18 20
Total Animals with Benign Neoplasms 17 10 10
Total Benign Neoplasms 18 11 13
Total Animals with Malignant Neoplasms 17 7 7
Total Malignant Neoplasms 20 7 7
Total Animals with Metastatic Neoplasms 2 2
Total Metastatic Neoplasm 2 10
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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