TR 381 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC CARVONE DATE: 09/04/94
EXPERIMENT: 05032 TEST: 02 TIME: 19:33:28
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: ROUTE: GAVAGE NTP C#: 55867A
PATHOLOGIST: DR. A. BOOTHE S. EUSTIS CAS: 99490
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC CARVONE DATE: 09/04/94
EXPERIMENT: 05032 TEST: 02 TIME: 19:33:28
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: ROUTE: GAVAGE NTP C#: 55867A
PATHOLOGIST: DR. A. BOOTHE S. EUSTIS CAS: 99490
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC CARVONE DATE: 09/04/94
EXPERIMENT: 05032 TEST: 02 TIME: 19:33:28
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: ROUTE: GAVAGE NTP C#: 55867A
PATHOLOGIST: DR. A. BOOTHE S. EUSTIS CAS: 99490
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF CARVONE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Skin: Subcutaneous Tissue Neurofibrosarcoma, Fibrosarcoma, Sarcoma,
Neurofibroma, or Fibroma
Neurofibrosarcoma, Fibrosarcoma, or Sarcoma
All Organs Hemangiosarcoma or Hemangioma
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Skeletal Muscle Sarcoma
====================================================================================================
DATE: 09/04/94 EXPERIMENT: 05032 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CARVONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 375 750 | VEHICLE 375 750 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/48 (4%) 0/49 (0%) 0/48 (0%) | 0/49 (0%) 0/48 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.6% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/36 (6%) 0/42 (0%) 0/36 (0%) | 0/13 (0%) 0/29 (0%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.090N P=0.205N P=0.238N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.090N P=0.205N P=0.238N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.090N P=0.205N P=0.238N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.095N | (e) |
|FISHER EXACT | P=0.242N P=0.247N | (e) (e) |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 1/50 (2%) | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.7% 4.5% 2.8% | 5.8% 0.0% 0.0% |
|TERMINAL (d) | 1/37 (3%) 1/42 (2%) 1/36 (3%) | 0/14 (0%) 0/29 (0%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 525 729 (T) | 522 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.610 P=0.534 P=0.756 | P=0.076N P=0.219N P=0.192N |
|INCIDENTAL TUMOR | P=0.595N P=0.529 P=0.756 | P=0.277N P=0.485N P=0.539N |
|LOGISTIC REGRESSION | P=0.617 P=0.491 P=0.756 | P=0.098N P=0.232N P=0.246N |
|COCHRAN-ARMITAGE | P=0.622N | P=0.095N |
|FISHER EXACT | P=0.500 P=0.753N | P=0.247N P=0.247N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05032 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CARVONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 375 750 | VEHICLE 375 750 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 4/50 (8%) 4/49 (8%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.4% 9.5% 10.5% | 4.8% 0.0% 0.0% |
|TERMINAL (d) | 2/37 (5%) 4/42 (10%) 3/36 (8%) | 0/14 (0%) 0/29 (0%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 498 | 695 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.255 P=0.397 P=0.321 | P=0.191N P=0.429N P=0.382N |
|INCIDENTAL TUMOR | P=0.279 P=0.397 P=0.358 | P=0.567N P=0.731N P=0.892N |
|LOGISTIC REGRESSION | P=0.244 P=0.397 P=0.311 | P=0.239N P=0.471N P=0.460N |
|COCHRAN-ARMITAGE | P=0.265 | P=0.269N |
|FISHER EXACT | P=0.339 P=0.329 | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 3/50 (6%) 3/49 (6%) | 0/50 (0%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 13.5% 7.1% 8.3% | 0.0% 5.7% 2.6% |
|TERMINAL (d) | 5/37 (14%) 3/42 (7%) 3/36 (8%) | 0/14 (0%) 1/29 (3%) 1/38 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) | --- 565 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.289N P=0.288N P=0.370N | P=0.535 P=0.327 P=0.699 |
|INCIDENTAL TUMOR | P=0.289N P=0.288N P=0.370N | P=0.451 P=0.317 P=0.699 |
|LOGISTIC REGRESSION | P=0.289N P=0.288N P=0.370N | P=0.375 P=0.237 P=0.699 |
|COCHRAN-ARMITAGE | P=0.292N | P=0.360 |
|FISHER EXACT | P=0.357N P=0.369N | P=0.247 P=0.500 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05032 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CARVONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 375 750 | VEHICLE 375 750 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 7/50 (14%) 7/49 (14%) | 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 18.9% 16.7% 18.7% | 4.8% 5.7% 2.6% |
|TERMINAL (d) | 7/37 (19%) 7/42 (17%) 6/36 (17%) | 0/14 (0%) 1/29 (3%) 1/38 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 498 | 695 565 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.535 P=0.513N P=0.589 | P=0.421N P=0.630 P=0.576N |
|INCIDENTAL TUMOR | P=0.556 P=0.513N P=0.612N | P=0.565 P=0.457 P=0.735 |
|LOGISTIC REGRESSION | P=0.511 P=0.513N P=0.565 | P=0.596N P=0.509 P=0.686N |
|COCHRAN-ARMITAGE | P=0.541 | P=0.622N |
|FISHER EXACT | P=0.613N P=0.597 | P=0.500 P=0.753N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 7/50 (14%) 7/49 (14%) | 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 18.9% 16.7% 18.7% | 4.8% 5.7% 2.6% |
|TERMINAL (d) | 7/37 (19%) 7/42 (17%) 6/36 (17%) | 0/14 (0%) 1/29 (3%) 1/38 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 498 | 695 565 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.535 P=0.513N P=0.589 | P=0.421N P=0.630 P=0.576N |
|INCIDENTAL TUMOR | P=0.556 P=0.513N P=0.612N | P=0.565 P=0.457 P=0.735 |
|LOGISTIC REGRESSION | P=0.511 P=0.513N P=0.565 | P=0.596N P=0.509 P=0.686N |
|COCHRAN-ARMITAGE | P=0.541 | P=0.622N |
|FISHER EXACT | P=0.613N P=0.597 | P=0.500 P=0.753N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05032 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CARVONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 375 750 | VEHICLE 375 750 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 4/50 (8%) 5/50 (10%) | 1/50 (2%) 6/50 (12%) 3/50 (6%) |
|ADJUSTED (b) | 17.0% 9.5% 13.9% | 3.1% 19.7% 7.6% |
|TERMINAL (d) | 4/37 (11%) 4/42 (10%) 5/36 (14%) | 0/14 (0%) 5/29 (17%) 2/38 (5%) |
|FIRST INCIDENCE (DAYS) | 337 729 (T) 729 (T) | 638 645 690 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.331N P=0.208N P=0.405N | P=0.515N P=0.190 P=0.561 |
|INCIDENTAL TUMOR | P=0.340N P=0.309N P=0.411N | P=0.343 P=0.122 P=0.220 |
|LOGISTIC REGRESSION | P=0.342N P=0.264N P=0.410N | P=0.417 P=0.089 P=0.375 |
|COCHRAN-ARMITAGE | P=0.314N | P=0.274 |
|FISHER EXACT | P=0.262N P=0.380N | P=0.056 P=0.309 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 5/50 (10%) 6/50 (12%) | 1/50 (2%) 6/50 (12%) 3/50 (6%) |
|ADJUSTED (b) | 17.0% 11.9% 16.2% | 3.1% 19.7% 7.6% |
|TERMINAL (d) | 4/37 (11%) 5/42 (12%) 5/36 (14%) | 0/14 (0%) 5/29 (17%) 2/38 (5%) |
|FIRST INCIDENCE (DAYS) | 337 729 (T) 707 | 638 645 690 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.459N P=0.308N P=0.522N | P=0.515N P=0.190 P=0.561 |
|INCIDENTAL TUMOR | P=0.480N P=0.424N P=0.548N | P=0.343 P=0.122 P=0.220 |
|LOGISTIC REGRESSION | P=0.476N P=0.379N P=0.536N | P=0.417 P=0.089 P=0.375 |
|COCHRAN-ARMITAGE | P=0.439N | P=0.274 |
|FISHER EXACT | P=0.380N P=0.500N | P=0.056 P=0.309 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05032 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CARVONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 375 750 | VEHICLE 375 750 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/40 (0%) 0/48 (0%) 0/48 (0%) | 1/46 (2%) 0/49 (0%) 2/48 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 6.3% 0.0% 5.6% |
|TERMINAL (d) | 0/28 (0%) 0/40 (0%) 0/35 (0%) | 0/12 (0%) 0/29 (0%) 2/36 (6%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 709 --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.620 P=0.381N P=0.652N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.350 P=0.718N P=0.568 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.525 P=0.430N P=0.729 |
|COCHRAN-ARMITAGE | (e) | P=0.371 |
|FISHER EXACT | (e) (e) | P=0.484N P=0.516 |
|=================================================================================================================================|
| |
|Skeletal Muscle |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 0.0% 4.5% |
|TERMINAL (d) | 0/37 (0%) 0/42 (0%) 0/36 (0%) | 0/14 (0%) 0/29 (0%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- --- 535 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.116 (e) P=0.282 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.035 * (e) P=0.089 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.089 (e) P=0.229 |
|COCHRAN-ARMITAGE | (e) | P=0.095 |
|FISHER EXACT | (e) (e) | (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05032 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CARVONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 375 750 | VEHICLE 375 750 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.4% 0.0% 2.8% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/37 (5%) 0/42 (0%) 1/36 (3%) | 0/14 (0%) 0/29 (0%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 729 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.364N P=0.211N P=0.510N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.364N P=0.211N P=0.510N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.364N P=0.211N P=0.510N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.360N | (e) |
|FISHER EXACT | P=0.247N P=0.500N | (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.3% 2.4% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/37 (3%) 1/42 (2%) 0/36 (0%) | 0/14 (0%) 0/29 (0%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 699 729 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.141N P=0.456N P=0.243N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.161N P=0.504N P=0.274N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.147N P=0.480N P=0.250N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.142N | (e) |
|FISHER EXACT | P=0.500N P=0.247N | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05032 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CARVONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 375 750 | VEHICLE 375 750 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 1/50 (2%) 3/50 (6%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 21.2% 2.4% 7.9% | 0.0% 3.4% 0.0% |
|TERMINAL (d) | 4/37 (11%) 1/42 (2%) 2/36 (6%) | 0/14 (0%) 1/29 (3%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 592 729 (T) 592 | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.030N* P=0.008N** P=0.080N | P=0.608N P=0.645 (e) |
|INCIDENTAL TUMOR | P=0.057N P=0.020N* P=0.124N | P=0.608N P=0.645 (e) |
|LOGISTIC REGRESSION | P=0.083N P=0.023N* P=0.072N | P=0.608N P=0.645 (e) |
|COCHRAN-ARMITAGE | P=0.025N* | P=0.731 |
|FISHER EXACT | P=0.008N** P=0.061N | P=0.500 (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 1/50 (2%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 16.4% 2.4% 5.1% | 0.0% 3.4% 0.0% |
|TERMINAL (d) | 2/37 (5%) 1/42 (2%) 1/36 (3%) | 0/14 (0%) 1/29 (3%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 592 729 (T) 592 | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.041N* P=0.028N* P=0.100N | P=0.608N P=0.645 (e) |
|INCIDENTAL TUMOR | P=0.082N P=0.070N P=0.160N | P=0.608N P=0.645 (e) |
|LOGISTIC REGRESSION | P=0.126N P=0.085N P=0.263N | P=0.608N P=0.645 (e) |
|COCHRAN-ARMITAGE | P=0.036N* | P=0.731 |
|FISHER EXACT | P=0.030N* P=0.080N | P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05032 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CARVONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 375 750 | VEHICLE 375 750 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 9.7% 0.0% 5.1% | 0.0% 3.4% 0.0% |
|TERMINAL (d) | 1/37 (3%) 0/42 (0%) 1/36 (3%) | 0/14 (0%) 1/29 (3%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 637 --- 592 | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.236N P=0.057N P=0.362N | P=0.608N P=0.645 (e) |
|INCIDENTAL TUMOR | P=0.357N P=0.114N P=0.496N | P=0.608N P=0.645 (e) |
|LOGISTIC REGRESSION | P=0.513N P=0.063N P=0.683 | P=0.608N P=0.645 (e) |
|COCHRAN-ARMITAGE | P=0.222N | P=0.731 |
|FISHER EXACT | P=0.059N P=0.339N | P=0.500 (e) |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 2.7% 2.4% 0.0% | 0.0% 10.3% 0.0% |
|TERMINAL (d) | 1/37 (3%) 1/42 (2%) 0/36 (0%) | 0/14 (0%) 3/29 (10%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.334N P=0.733N P=0.505N | P=0.380N P=0.274 (e) |
|INCIDENTAL TUMOR | P=0.334N P=0.733N P=0.505N | P=0.380N P=0.274 (e) |
|LOGISTIC REGRESSION | P=0.334N P=0.733N P=0.505N | P=0.380N P=0.274 (e) |
|COCHRAN-ARMITAGE | P=0.331N | P=0.640 |
|FISHER EXACT | P=0.753N P=0.500N | P=0.121 (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05032 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CARVONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 375 750 | VEHICLE 375 750 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 2.7% 2.4% 0.0% | 0.0% 10.3% 0.0% |
|TERMINAL (d) | 1/37 (3%) 1/42 (2%) 0/36 (0%) | 0/14 (0%) 3/29 (10%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- | --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.334N P=0.733N P=0.505N | P=0.380N P=0.274 (e) |
|INCIDENTAL TUMOR | P=0.334N P=0.733N P=0.505N | P=0.380N P=0.274 (e) |
|LOGISTIC REGRESSION | P=0.334N P=0.733N P=0.505N | P=0.380N P=0.274 (e) |
|COCHRAN-ARMITAGE | P=0.331N | P=0.640 |
|FISHER EXACT | P=0.753N P=0.500N | P=0.121 (e) |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | | 0.0% 0.0% 5.3% |
|TERMINAL (d) | | 0/14 (0%) 0/29 (0%) 2/38 (5%) |
|FIRST INCIDENCE (DAYS) | | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.193 (e) P=0.475 |
|INCIDENTAL TUMOR | | P=0.193 (e) P=0.475 |
|LOGISTIC REGRESSION | | P=0.193 (e) P=0.475 |
|COCHRAN-ARMITAGE | | P=0.095 |
|FISHER EXACT | | (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05032 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CARVONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 375 750 | VEHICLE 375 750 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.4% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/37 (5%) 0/42 (0%) 0/36 (0%) | 0/14 (0%) 0/29 (0%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.093N P=0.211N P=0.244N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.093N P=0.211N P=0.244N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.093N P=0.211N P=0.244N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.095N | (e) |
|FISHER EXACT | P=0.247N P=0.247N | (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.1% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/37 (8%) 0/42 (0%) 0/36 (0%) | 0/14 (0%) 0/29 (0%) 0/38 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.035N* P=0.100N P=0.126N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.035N* P=0.100N P=0.126N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.035N* P=0.100N P=0.126N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.037N* | (e) |
|FISHER EXACT | P=0.121N P=0.121N | (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05032 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CARVONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 375 750 | VEHICLE 375 750 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 2/50 (4%) 1/50 (2%) | 2/50 (4%) 4/50 (8%) 4/50 (8%) |
|ADJUSTED (b) | 12.5% 4.4% 2.6% | 10.7% 11.5% 10.5% |
|TERMINAL (d) | 3/37 (8%) 0/42 (0%) 0/36 (0%) | 1/14 (7%) 2/29 (7%) 4/38 (11%) |
|FIRST INCIDENCE (DAYS) | 504 552 695 | 676 580 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.065N P=0.186N P=0.115N | P=0.529N P=0.546 P=0.589N |
|INCIDENTAL TUMOR | P=0.087N P=0.300N P=0.110N | P=0.405 P=0.417 P=0.604 |
|LOGISTIC REGRESSION | P=0.059N P=0.225N P=0.111N | P=0.365 P=0.364 P=0.593 |
|COCHRAN-ARMITAGE | P=0.060N | P=0.274 |
|FISHER EXACT | P=0.218N P=0.102N | P=0.339 P=0.339 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 2/50 (4%) 1/50 (2%) | 2/50 (4%) 4/50 (8%) 4/50 (8%) |
|ADJUSTED (b) | 12.5% 4.4% 2.6% | 10.7% 11.5% 10.5% |
|TERMINAL (d) | 3/37 (8%) 0/42 (0%) 0/36 (0%) | 1/14 (7%) 2/29 (7%) 4/38 (11%) |
|FIRST INCIDENCE (DAYS) | 504 552 695 | 676 580 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.065N P=0.186N P=0.115N | P=0.529N P=0.546 P=0.589N |
|INCIDENTAL TUMOR | P=0.087N P=0.300N P=0.110N | P=0.405 P=0.417 P=0.604 |
|LOGISTIC REGRESSION | P=0.059N P=0.225N P=0.111N | P=0.365 P=0.364 P=0.593 |
|COCHRAN-ARMITAGE | P=0.060N | P=0.274 |
|FISHER EXACT | P=0.218N P=0.102N | P=0.339 P=0.339 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05032 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CARVONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 375 750 | VEHICLE 375 750 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 17/50 (34%) 10/50 (20%) 10/50 (20%) | 6/50 (12%) 8/50 (16%) 7/50 (14%) |
|ADJUSTED (b) | 42.1% 23.1% 26.8% | 24.4% 26.4% 17.9% |
|TERMINAL (d) | 14/37 (38%) 9/42 (21%) 9/36 (25%) | 1/14 (7%) 7/29 (24%) 6/38 (16%) |
|FIRST INCIDENCE (DAYS) | 337 525 498 | 522 645 690 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.075N P=0.047N* P=0.107N | P=0.140N P=0.447N P=0.219N |
|INCIDENTAL TUMOR | P=0.067N P=0.073N P=0.098N | P=0.512 P=0.409 P=0.409 |
|LOGISTIC REGRESSION | P=0.085N P=0.077N P=0.118N | P=0.471N P=0.486 P=0.607N |
|COCHRAN-ARMITAGE | P=0.066N | P=0.443 |
|FISHER EXACT | P=0.088N P=0.088N | P=0.387 P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 17/50 (34%) 7/50 (14%) 7/50 (14%) | 3/50 (6%) 9/50 (18%) 8/50 (16%) |
|ADJUSTED (b) | 39.3% 15.8% 17.7% | 17.6% 24.8% 19.5% |
|TERMINAL (d) | 11/37 (30%) 5/42 (12%) 4/36 (11%) | 2/14 (14%) 5/29 (17%) 6/38 (16%) |
|FIRST INCIDENCE (DAYS) | 504 552 592 | 676 435 535 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.014N* P=0.012N* P=0.030N* | P=0.470 P=0.236 P=0.512 |
|INCIDENTAL TUMOR | P=0.022N* P=0.031N* P=0.036N* | P=0.186 P=0.127 P=0.250 |
|LOGISTIC REGRESSION | P=0.029N* P=0.016N* P=0.052N | P=0.111 P=0.067 P=0.161 |
|COCHRAN-ARMITAGE | P=0.009N** | P=0.093 |
|FISHER EXACT | P=0.017N* P=0.017N* | P=0.061 P=0.100 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05032 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- CARVONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 375 750 | VEHICLE 375 750 |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 27/50 (54%) 15/50 (30%) 16/50 (32%) | 9/50 (18%) 15/50 (30%) 14/50 (28%) |
|ADJUSTED (b) | 61.1% 33.2% 39.8% | 38.5% 42.2% 33.8% |
|TERMINAL (d) | 20/37 (54%) 12/42 (29%) 12/36 (33%) | 3/14 (21%) 10/29 (34%) 11/38 (29%) |
|FIRST INCIDENCE (DAYS) | 337 525 498 | 522 435 535 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.027N* P=0.007N** P=0.043N* | P=0.246N P=0.542 P=0.301N |
|INCIDENTAL TUMOR | P=0.029N* P=0.017N* P=0.039N* | P=0.217 P=0.162 P=0.205 |
|LOGISTIC REGRESSION | P=0.023N* P=0.011N* P=0.035N* | P=0.236 P=0.151 P=0.300 |
|COCHRAN-ARMITAGE | P=0.016N* | P=0.150 |
|FISHER EXACT | P=0.013N* P=0.021N* | P=0.121 P=0.171 |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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