TR 381 Mouse Pathology Tables
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
Facility: International Research and Development Corp.
Chemical CAS #: 99490
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 6| 6| 6| 7| 4| 4| 5| 6| 7|
DAY ON TEST | 6| 2| 3| 3| 2| 8| 5| 3| 2| 3| 2| 7| 2| 3| 3| 0| 0| 9| 9| 0| 1| 6| 7| 4| 3|
| 5| 9| 0| 1| 9| 3| 8| 1| 9| 1| 0| 9| 7| 0| 1| 7| 9| 2| 5| 9| 7| 5| 6| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Muscularis, Inflammation, | |
Acute, Diffuse | |
Periesophageal Tissue, Abscess, Focal| |
Periesophageal Tissue, Abscess, | |
Multifocal | 2 |
__________________________________________________________________________|
Gallbladder | + + + + + + M + + + + + A + M + A M + + A + A + +|
Infiltration Cellular, Diffuse, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 2 |
Inflammation, Acute, Diffuse | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 1 1 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + M + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + M + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Multifocal | 1 1 1 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 1 3 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Inflammation, Acute, Multifocal | 2 |
Bile Duct, Infiltration Cellular, | |
Multifocal, Lymphocyte | 1 2 2 |
Serosa, Abscess, Focal | |
Serosa, Inflammation, Acute, | |
Multifocal | |
Serosa, Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Abscess, Focal | |
Abscess, Multifocal | 4 4 2 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Multifocal | 4 |
Atrophy, Diffuse | 4 |
Atrophy, Focal | 4 |
Atrophy, Multifocal | 1 |
Inflammation, Acute, Diffuse | 4 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 6| 6| 6| 7| 4| 4| 5| 6| 7|
DAY ON TEST | 6| 2| 3| 3| 2| 8| 5| 3| 2| 3| 2| 7| 2| 3| 3| 0| 0| 9| 9| 0| 1| 6| 7| 4| 3|
| 5| 9| 0| 1| 9| 3| 8| 1| 9| 1| 0| 9| 7| 0| 1| 7| 9| 2| 5| 9| 7| 5| 6| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Acute, Multifocal | |
Inflammation, Chronic, Diffuse | 1 |
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic, Multifocal | 2 1 |
Necrosis, Multifocal | 2 |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 1 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 3 3 3 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + M + + + + + + + +|
Abscess, Focal | |
Acanthosis, Focal | 3 2 3 |
Acanthosis, Multifocal | |
Hyperkeratosis, Focal | |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Media, Mineralization, Diffuse| 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic, Focal | 3 |
Epicardium, Inflammation, Acute, | |
Diffuse | |
Epicardium, Inflammation, Acute, | |
Focal | 2 |
Epicardium, Inflammation, Acute, | |
Multifocal | 2 2 |
Epicardium, Inflammation, Chronic, | |
Diffuse | |
Epicardium, Inflammation, Chronic, | |
Multifocal | 2 |
Myocardium, Inflammation, Acute, | |
Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 6| 6| 6| 7| 4| 4| 5| 6| 7|
DAY ON TEST | 6| 2| 3| 3| 2| 8| 5| 3| 2| 3| 2| 7| 2| 3| 3| 0| 0| 9| 9| 0| 1| 6| 7| 4| 3|
| 5| 9| 0| 1| 9| 3| 8| 1| 9| 1| 0| 9| 7| 0| 1| 7| 9| 2| 5| 9| 7| 5| 6| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cyst, Single | 1 |
Hematopoietic Cell Proliferation, | |
Diffuse | |
Hematopoietic Cell Proliferation, | |
Focal | |
Hematopoietic Cell Proliferation, | |
Multifocal | 1 1 |
Bilateral, Hematopoietic Cell | |
Proliferation, Diffuse | 3 |
Bilateral, Hematopoietic Cell | |
Proliferation, Multifocal | 1 2 |
Bilateral, Vacuolization Cytoplasmic,| |
Diffuse | 3 |
Bilateral, Spindle Cell, Hyperplasia,| |
Diffuse | 2 2 3 3 2 2 3 2 2 2 2 2 2 2 2 2|
Bilateral, Spindle Cell, Hyperplasia,| |
Multifocal | 1 2 2 2 2 2 2 |
Spindle Cell, Hyperplasia, Diffuse | 2 |
Spindle Cell, Hyperplasia, Multifocal| 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + M M + M + + + M M + M + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + I + +|
Hypertrophy, Focal | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma, Focal | 3 |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | 1 |
Ultimobranchial Cyst | X X X X X X X |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Focal | 4 2 |
Abscess, Multifocal | 4 4 4 4 |
Cyst, Multiple | |
Cyst, Single | 1 1 3 3 2 |
Bilateral, Abscess, Multifocal | 4 4 4 |
Bilateral, Cyst, Multiple | 3 2 |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 6| 6| 6| 7| 4| 4| 5| 6| 7|
DAY ON TEST | 6| 2| 3| 3| 2| 8| 5| 3| 2| 3| 2| 7| 2| 3| 3| 0| 0| 9| 9| 0| 1| 6| 7| 4| 3|
| 5| 9| 0| 1| 9| 3| 8| 1| 9| 1| 0| 9| 7| 0| 1| 7| 9| 2| 5| 9| 7| 5| 6| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Abscess, Focal | |
Abscess, Multifocal | 4 4 4 |
Dilatation | 3 2 2 |
Inflammation, Acute, Diffuse | 2 4 2 |
Endometrium, Hyperplasia, Cystic, | |
Diffuse | 2 2 1 2 4 2 3 1 2|
Endometrium, Hyperplasia, Cystic, | |
Multifocal | 2 |
Lumen, Exudate | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia, Diffuse | 3 |
Myelofibrosis, Focal | 2 2 |
Myeloid Cell, Hyperplasia, Diffuse | 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + M + + + + + + + + + + + + + + + I + +|
Bronchial, Abscess, Focal | 4 |
Bronchial, Hyperplasia, Diffuse, | |
Lymphoid | 2 |
Bronchial, Infiltration Cellular, | |
Diffuse, Plasma Cell | 3 |
Iliac, Hyperplasia, Lymphoid, | |
Multifocal | |
Iliac, Infiltration Cellular, | |
Diffuse, Plasma Cell | 3 3 |
Inguinal, Infiltration Cellular, | |
Diffuse, Plasma Cell | 3 3 |
Mediastinal, Abscess, Focal | |
Mediastinal, Infiltration Cellular, | |
Diffuse, Plasma Cell | 3 |
Renal, Infiltration Cellular, | |
Diffuse, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + |
Hyperplasia, Diffuse, Lymphoid | |
Hyperplasia, Lymphoid, Multifocal | 2 2 |
Infiltration Cellular, Diffuse, | |
Plasma Cell | 3 3 3 |
Sinus, Ectasia, Diffuse | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M M + + + + + + + + + + + + + + + I + +|
Hematopoietic Cell Proliferation, | |
Multifocal | |
Hyperplasia, Diffuse, Lymphoid | |
Hyperplasia, Diffuse, Re Cell | 2 3 |
Hyperplasia, Focal, Lymphoid | 1 1 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 6| 6| 6| 7| 4| 4| 5| 6| 7|
DAY ON TEST | 6| 2| 3| 3| 2| 8| 5| 3| 2| 3| 2| 7| 2| 3| 3| 0| 0| 9| 9| 0| 1| 6| 7| 4| 3|
| 5| 9| 0| 1| 9| 3| 8| 1| 9| 1| 0| 9| 7| 0| 1| 7| 9| 2| 5| 9| 7| 5| 6| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid, Multifocal | 2 |
Infiltration Cellular, Diffuse, | |
Plasma Cell | |
Inflammation, Acute, Focal | |
Necrosis, Caseous, Diffuse | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid, Diffuse | 2 |
Hematopoietic Cell Proliferation, | |
Diffuse | 1 2 1 3 1 3 3 2 3 1 3 |
Hyperplasia, Diffuse, Lymphoid | 2 2 2 |
Hyperplasia, Lymphoid, Multifocal | |
Pigmentation, Diffuse | 2 2 2 1 1 |
Artery, Trabecula, Amyloid | |
Deposition, Multifocal | 2 |
Capsule, Inflammation, Acute, Diffuse| |
Capsule, Inflammation, Acute, | |
Multifocal | |
Capsule, Inflammation, Chronic, | |
Diffuse | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + M + M + M + + + M + + + + + +|
Abscess, Multifocal | 4 |
Atrophy, Diffuse | 3 3 4 1 4 4 3 3 3 |
Hyperplasia, Lymphoid, Multifocal | 1 |
Mediastinum, Abscess, Focal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Diffuse | 1 1 2 2 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + |
Acanthosis, Focal | 2 |
Acanthosis, Multifocal | 1 |
Back, Subcutaneous Tissue, Abscess, | |
Focal | |
Hair Follicle, Atrophy, Diffuse | 3 2 |
Hair Follicle, Atrophy, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy, | |
Diffuse | 2 2 3 |
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Acute, Diffuse | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 6| 6| 6| 7| 4| 4| 5| 6| 7|
DAY ON TEST | 6| 2| 3| 3| 2| 8| 5| 3| 2| 3| 2| 7| 2| 3| 3| 0| 0| 9| 9| 0| 1| 6| 7| 4| 3|
| 5| 9| 0| 1| 9| 3| 8| 1| 9| 1| 0| 9| 7| 0| 1| 7| 9| 2| 5| 9| 7| 5| 6| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Thalamus, Mineralization, | |
Multifocal | 1 1 1 1 2 1 1|
Meninges, Abscess, Focal | 4 |
Meninges, Inflammation, Acute, Focal | 4 |
Thalamus, Mineralization, Focal | 1 1 |
Thalamus, Mineralization, Multifocal | 1 |
Ventricle, Abscess, Multifocal | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Multifocal | |
Bacterium, Multifocal | 3 |
Congestion, Multifocal | 1 |
Hemorrhage, Focal | 1 |
Hemorrhage, Multifocal | 1 |
Alveolar Epithelium, Hyperplasia | 2|
Artery, Adventitia, Inflammation, | |
Chronic, Multifocal | 3 |
Artery, Media, Hypertrophy, | |
Multifocal | 2 3 3 |
Peribronchial, Infiltration Cellular,| |
Multifocal, Lymphocyte | 1 2 2 2 1 2 2 3 2 2 3 1 3 2 3 2|
Peribronchiolar, Infiltration | |
Cellular, Multifocal, Lymphocyte | 3 |
Perivascular, Infiltration Cellular, | |
Diffuse, Lymphocyte | |
Perivascular, Infiltration Cellular, | |
Multifocal, Lymphocyte | 3 2 2 2 3 |
Pleura, Foreign Body, Focal | |
Pleura, Granuloma, Focal | |
Pleura, Inflammation, Acute, Diffuse | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 1 2 1 2 2 1 2 2 1 1 2 1 1 2 2 1|
Glands, Hyperplasia | 1 2 1 1 1 1 |
Nasolacrimal Duct, Exudate, Diffuse | 2 |
Olfactory Epithelium, Atrophy | 1 3 3 3 2 2 2 2 2 2 |
Turbinate, Exudate | 3 3 2 2 3 2 2 2 |
Turbinate, Fungus, Multifocal | 3 |
Turbinate, Hemorrhage, Focal | |
Turbinate, Inflammation, Acute, | |
Diffuse | |
Turbinate, Inflammation, Acute, | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 6| 6| 6| 7| 4| 4| 5| 6| 7|
DAY ON TEST | 6| 2| 3| 3| 2| 8| 5| 3| 2| 3| 2| 7| 2| 3| 3| 0| 0| 9| 9| 0| 1| 6| 7| 4| 3|
| 5| 9| 0| 1| 9| 3| 8| 1| 9| 1| 0| 9| 7| 0| 1| 7| 9| 2| 5| 9| 7| 5| 6| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Multifocal | 1 1 2 |
Turbinate, Inflammation, Chronic, | |
Diffuse | 3 |
Turbinate, Inflammation, Chronic, | |
Focal | |
Turbinate, Inflammation, Chronic, | |
Multifocal | 2 1 2 1 2 2 2 2 3 1 2 1 1 1 |
Turbinate, Ulcer, Focal | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + A + + + + + + + +|
Inflammation, Chronic, Diffuse | 1 1 |
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic, Multifocal | 1 1 1 1 |
Peritracheal Tissue, Abscess, | |
Multifocal | |
Peritracheal Tissue, Inflammation, | |
Acute, Focal | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | A |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | 3 |
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic, Multifocal | 2 |
Bilateral, Abscess, Multifocal | |
Bilateral, Glomerulosclerosis, | |
Diffuse | 4 |
Bilateral, Inflammation, Chronic, | |
Diffuse | 3 |
Bilateral, Inflammation, Chronic, | |
Multifocal | 2 1 2 2 1 2 1 1 2 1 2 1 1 |
Bilateral, Pelvis, Bacterium, | |
Multifocal | |
Glomerulus, Renal Tubule, Amyloid | |
Deposition, Diffuse | 4 |
Interstitial Tissue, Renal Tubule, | |
Pigmentation, Multifocal | 1 |
Left, Hydronephrosis | |
Pelvis, Bacterium, Focal | 3 |
Pelvis, Bacterium, Multifocal | |
Pelvis, Concretion, Multifocal | 2 |
Renal Tubule, Bacterium, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 6| 6| 6| 7| 4| 4| 5| 6| 7|
DAY ON TEST | 6| 2| 3| 3| 2| 8| 5| 3| 2| 3| 2| 7| 2| 3| 3| 0| 0| 9| 9| 0| 1| 6| 7| 4| 3|
| 5| 9| 0| 1| 9| 3| 8| 1| 9| 1| 0| 9| 7| 0| 1| 7| 9| 2| 5| 9| 7| 5| 6| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Casts Protein, | |
Multifocal | 2 |
Renal Tubule, Degeneration, Focal | 3 |
Renal Tubule, Regeneration, Focal | |
Renal Tubule, Regeneration, | |
Multifocal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + + + + + + + + M + + + + + + + +|
Abscess, Focal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 1 4 2 2 1 2 3 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 6| 4| 5| 5| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 7| 4| 7| 7| 7| 6| |
DAY ON TEST | 3| 2| 3| 0| 7| 3| 9| 9| 0| 9| 4| 5| 2| 8| 3| 2| 1| 3| 7| 0| 9| 0| 0| 3| 9| |
| 3| 9| 3| 5| 0| 6| 1| 8| 8| 3| 3| 3| 9| 1| 1| 2| 0| 8| 6| 8| 1| 9| 7| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mucosa, Muscularis, Inflammation, | | |
Acute, Diffuse | 3 | 1 3.0|
Periesophageal Tissue, Abscess, Focal| 4 | 1 4.0|
Periesophageal Tissue, Abscess, | | |
Multifocal | 4 | 2 3.0|
__________________________________________________________________________|____________|
Gallbladder | A + A A M + + + + A + + + M + A M + M A + + A + M| 31 |
Infiltration Cellular, Diffuse, | | |
Lymphocyte | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 2 1.5|
Inflammation, Acute, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + M + + M| 47 |
Inflammation, Acute, Focal | 1 | 5 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + + + + A + + + + + + + + + + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + A + A + + + + + + + + + + A| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A A + + + + + + A + + + + + + + + + + + + A| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + A A + + + + + + A + A + + + + + + + + + + A| 41 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 1 3 1 2 2 2 1 2 2 1 2 2 2 2| 18 1.7|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 3 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 2 2.0|
Inflammation, Acute, Multifocal | | 1 2.0|
Bile Duct, Infiltration Cellular, | | |
Multifocal, Lymphocyte | | 3 1.7|
Serosa, Abscess, Focal | 4 | 1 4.0|
Serosa, Inflammation, Acute, | | |
Multifocal | 4 3 | 2 3.5|
Serosa, Inflammation, Chronic, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + +| 20 |
Abscess, Focal | 3 | 1 3.0|
Abscess, Multifocal | 3 4 4 4 4 3 4 4 4 4 4 4 4| 19 3.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 6| 4| 5| 5| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 7| 4| 7| 7| 7| 6| |
DAY ON TEST | 3| 2| 3| 0| 7| 3| 9| 9| 0| 9| 4| 5| 2| 8| 3| 2| 1| 3| 7| 0| 9| 0| 0| 3| 9| |
| 3| 9| 3| 5| 0| 6| 1| 8| 8| 3| 3| 3| 9| 1| 1| 2| 0| 8| 6| 8| 1| 9| 7| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Abscess, Multifocal | 4 3 | 3 3.7|
Atrophy, Diffuse | | 1 4.0|
Atrophy, Focal | | 1 4.0|
Atrophy, Multifocal | 2 | 2 1.5|
Inflammation, Acute, Diffuse | 4 2 | 4 3.0|
Inflammation, Acute, Multifocal | 3 2 | 2 2.5|
Inflammation, Chronic, Diffuse | | 1 1.0|
Inflammation, Chronic, Focal | | 1 1.0|
Inflammation, Chronic, Multifocal | 1 1 | 4 1.3|
Necrosis, Multifocal | | 1 2.0|
Duct, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 3 1 | 4 1.5|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 2 2 2 | 11 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + M M + + + + + + + + + + + + +| 47 |
Abscess, Focal | 2 | 1 2.0|
Acanthosis, Focal | 3 2 | 5 2.6|
Acanthosis, Multifocal | 2 | 1 2.0|
Hyperkeratosis, Focal | 1 | 1 1.0|
Inflammation, Acute, Focal | 2 | 1 2.0|
Inflammation, Chronic, Focal | 2 2 3| 5 2.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + M + + + +| 48 |
Inflammation, Acute, Focal | 3 | 1 3.0|
Inflammation, Chronic, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Media, Mineralization, Diffuse| | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic, Focal | | 1 3.0|
Epicardium, Inflammation, Acute, | | |
Diffuse | 3 | 1 3.0|
Epicardium, Inflammation, Acute, | | |
Focal | | 1 2.0|
Epicardium, Inflammation, Acute, | | |
Multifocal | 2 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 6| 4| 5| 5| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 7| 4| 7| 7| 7| 6| |
DAY ON TEST | 3| 2| 3| 0| 7| 3| 9| 9| 0| 9| 4| 5| 2| 8| 3| 2| 1| 3| 7| 0| 9| 0| 0| 3| 9| |
| 3| 9| 3| 5| 0| 6| 1| 8| 8| 3| 3| 3| 9| 1| 1| 2| 0| 8| 6| 8| 1| 9| 7| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Epicardium, Inflammation, Chronic, | | |
Diffuse | 1 | 1 1.0|
Epicardium, Inflammation, Chronic, | | |
Multifocal | | 1 2.0|
Myocardium, Inflammation, Acute, | | |
Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Single | | 1 1.0|
Hematopoietic Cell Proliferation, | | |
Diffuse | 2 1 | 2 1.5|
Hematopoietic Cell Proliferation, | | |
Focal | 1 | 1 1.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | | 2 1.0|
Bilateral, Hematopoietic Cell | | |
Proliferation, Diffuse | | 1 3.0|
Bilateral, Hematopoietic Cell | | |
Proliferation, Multifocal | 1 2 2 2 2 1 1| 9 1.6|
Bilateral, Vacuolization Cytoplasmic,| | |
Diffuse | 2 | 2 2.5|
Bilateral, Spindle Cell, Hyperplasia,| | |
Diffuse | 2 3 2 2 2 2 3 2 3 3 2 2 2 3 2 2| 32 2.3|
Bilateral, Spindle Cell, Hyperplasia,| | |
Multifocal | 2 2 2 2 2 2 2 2 2 | 16 1.9|
Spindle Cell, Hyperplasia, Diffuse | | 1 2.0|
Spindle Cell, Hyperplasia, Multifocal| | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + M| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + M + + + M + + + + + + M M M + M M +| 33 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + M +| 46 |
Hypertrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Granuloma, Focal | | 1 3.0|
Inflammation, Acute, Focal | 1 | 1 1.0|
Inflammation, Chronic, Focal | | 1 1.0|
Ultimobranchial Cyst | X X X X X X | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 6| 4| 5| 5| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 7| 4| 7| 7| 7| 6| |
DAY ON TEST | 3| 2| 3| 0| 7| 3| 9| 9| 0| 9| 4| 5| 2| 8| 3| 2| 1| 3| 7| 0| 9| 0| 0| 3| 9| |
| 3| 9| 3| 5| 0| 6| 1| 8| 8| 3| 3| 3| 9| 1| 1| 2| 0| 8| 6| 8| 1| 9| 7| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess, Focal | 4 4 | 4 3.5|
Abscess, Multifocal | 4 4 4 4 4 4 4 4 4 4 4 4| 16 4.0|
Cyst, Multiple | 3 | 1 3.0|
Cyst, Single | 2 3 | 7 2.1|
Bilateral, Abscess, Multifocal | 4 4 4 | 6 4.0|
Bilateral, Cyst, Multiple | | 2 2.5|
__________________________________________________________________________|____________|
Oviduct | M | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess, Focal | 4 | 1 4.0|
Abscess, Multifocal | 4 4 4 3 4 4| 9 3.9|
Dilatation | 2 3 | 5 2.4|
Inflammation, Acute, Diffuse | | 3 2.7|
Endometrium, Hyperplasia, Cystic, | | |
Diffuse | 1 2 2 2 2 | 14 2.0|
Endometrium, Hyperplasia, Cystic, | | |
Multifocal | | 1 2.0|
Lumen, Exudate | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypoplasia, Diffuse | | 1 3.0|
Myelofibrosis, Focal | | 2 2.0|
Myeloid Cell, Hyperplasia, Diffuse | 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 |
Bronchial, Abscess, Focal | | 1 4.0|
Bronchial, Hyperplasia, Diffuse, | | |
Lymphoid | | 1 2.0|
Bronchial, Infiltration Cellular, | | |
Diffuse, Plasma Cell | | 1 3.0|
Iliac, Hyperplasia, Lymphoid, | | |
Multifocal | 3 | 1 3.0|
Iliac, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 6| 4| 5| 5| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 7| 4| 7| 7| 7| 6| |
DAY ON TEST | 3| 2| 3| 0| 7| 3| 9| 9| 0| 9| 4| 5| 2| 8| 3| 2| 1| 3| 7| 0| 9| 0| 0| 3| 9| |
| 3| 9| 3| 5| 0| 6| 1| 8| 8| 3| 3| 3| 9| 1| 1| 2| 0| 8| 6| 8| 1| 9| 7| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Diffuse, Plasma Cell | 2 2 | 4 2.5|
Inguinal, Infiltration Cellular, | | |
Diffuse, Plasma Cell | | 2 3.0|
Mediastinal, Abscess, Focal | 4 | 1 4.0|
Mediastinal, Infiltration Cellular, | | |
Diffuse, Plasma Cell | | 1 3.0|
Renal, Infiltration Cellular, | | |
Diffuse, Plasma Cell | 3 4 3| 4 3.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 7 |
Hyperplasia, Diffuse, Lymphoid | 2 | 1 2.0|
Hyperplasia, Lymphoid, Multifocal | | 2 2.0|
Infiltration Cellular, Diffuse, | | |
Plasma Cell | 3 | 4 3.0|
Sinus, Ectasia, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +| 46 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 | 1 2.0|
Hyperplasia, Diffuse, Lymphoid | 2 | 1 2.0|
Hyperplasia, Diffuse, Re Cell | 2 2 2 2 2 | 7 2.1|
Hyperplasia, Focal, Lymphoid | | 2 1.0|
Hyperplasia, Lymphoid, Multifocal | 1 | 2 1.5|
Infiltration Cellular, Diffuse, | | |
Plasma Cell | 3 2 | 2 2.5|
Inflammation, Acute, Focal | 1 | 1 1.0|
Necrosis, Caseous, Diffuse | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid, Diffuse | | 1 2.0|
Hematopoietic Cell Proliferation, | | |
Diffuse | 2 3 2 2 2 3 3 2 3 1 3 2 3 1 2 1 2 2 3 4 3| 32 2.3|
Hyperplasia, Diffuse, Lymphoid | 1 | 4 1.8|
Hyperplasia, Lymphoid, Multifocal | 2 | 1 2.0|
Pigmentation, Diffuse | 2 | 6 1.7|
Artery, Trabecula, Amyloid | | |
Deposition, Multifocal | | 1 2.0|
Capsule, Inflammation, Acute, Diffuse| 4 | 1 4.0|
Capsule, Inflammation, Acute, | | |
Multifocal | 4 | 1 4.0|
Capsule, Inflammation, Chronic, | | |
Diffuse | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 6| 4| 5| 5| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 7| 4| 7| 7| 7| 6| |
DAY ON TEST | 3| 2| 3| 0| 7| 3| 9| 9| 0| 9| 4| 5| 2| 8| 3| 2| 1| 3| 7| 0| 9| 0| 0| 3| 9| |
| 3| 9| 3| 5| 0| 6| 1| 8| 8| 3| 3| 3| 9| 1| 1| 2| 0| 8| 6| 8| 1| 9| 7| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | M + + M M + + + M + + M + + + + + + M M + + M M M| 35 |
Abscess, Multifocal | | 1 4.0|
Atrophy, Diffuse | 2 2 4 3 4 2 3 3 | 17 3.0|
Hyperplasia, Lymphoid, Multifocal | 1 | 2 1.0|
Mediastinum, Abscess, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + + + M| 48 |
Hyperplasia, Diffuse | 2 2 1 1 2 1 2 2 1 1 | 16 1.4|
__________________________________________________________________________|____________|
Skin | + + + + + + +| 16 |
Acanthosis, Focal | | 1 2.0|
Acanthosis, Multifocal | | 1 1.0|
Back, Subcutaneous Tissue, Abscess, | | |
Focal | 4 | 1 4.0|
Hair Follicle, Atrophy, Diffuse | 3 | 3 2.7|
Hair Follicle, Atrophy, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femur, Fibrous Osteodystrophy, | | |
Diffuse | | 3 2.3|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Inflammation, Acute, Diffuse | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Thalamus, Mineralization, | | |
Multifocal | 1 1 1 1 1 | 12 1.1|
Meninges, Abscess, Focal | | 1 4.0|
Meninges, Inflammation, Acute, Focal | | 1 4.0|
Thalamus, Mineralization, Focal | 1 | 3 1.0|
Thalamus, Mineralization, Multifocal | 1 1 1 1 | 5 1.0|
Ventricle, Abscess, Multifocal | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess, Multifocal | 4 | 1 4.0|
Bacterium, Multifocal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 6| 4| 5| 5| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 7| 4| 7| 7| 7| 6| |
DAY ON TEST | 3| 2| 3| 0| 7| 3| 9| 9| 0| 9| 4| 5| 2| 8| 3| 2| 1| 3| 7| 0| 9| 0| 0| 3| 9| |
| 3| 9| 3| 5| 0| 6| 1| 8| 8| 3| 3| 3| 9| 1| 1| 2| 0| 8| 6| 8| 1| 9| 7| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Congestion, Multifocal | | 1 1.0|
Hemorrhage, Focal | 2 | 2 1.5|
Hemorrhage, Multifocal | 2 | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Artery, Adventitia, Inflammation, | | |
Chronic, Multifocal | | 1 3.0|
Artery, Media, Hypertrophy, | | |
Multifocal | 2 | 4 2.5|
Peribronchial, Infiltration Cellular,| | |
Multifocal, Lymphocyte | 2 2 2 2 1 1 3 2 3 1 1 2 2 1 | 30 1.9|
Peribronchiolar, Infiltration | | |
Cellular, Multifocal, Lymphocyte | 1 | 2 2.0|
Perivascular, Infiltration Cellular, | | |
Diffuse, Lymphocyte | 2 | 1 2.0|
Perivascular, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 2 2 2 3 1 2 1 3 1 1 2| 16 2.0|
Pleura, Foreign Body, Focal | 1 | 1 1.0|
Pleura, Granuloma, Focal | 1 | 1 1.0|
Pleura, Inflammation, Acute, Diffuse | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Foreign Body | 2 2 2 2 2 2 2 1 2 3 2 1 2 1 2 2 1 1| 35 1.6|
Glands, Hyperplasia | 1 2 1 1 1 1 1 1 2 1 2 2 1| 19 1.3|
Nasolacrimal Duct, Exudate, Diffuse | | 1 2.0|
Olfactory Epithelium, Atrophy | 2 3 4 1 3 4 1 3 2 2 3 3 3 4 2| 25 2.5|
Turbinate, Exudate | 3 2 2 2 3 1 1 | 15 2.2|
Turbinate, Fungus, Multifocal | | 1 3.0|
Turbinate, Hemorrhage, Focal | 3 | 1 3.0|
Turbinate, Inflammation, Acute, | | |
Diffuse | 4 1 | 2 2.5|
Turbinate, Inflammation, Acute, | | |
Multifocal | 1 1 | 5 1.2|
Turbinate, Inflammation, Chronic, | | |
Diffuse | | 1 3.0|
Turbinate, Inflammation, Chronic, | | |
Focal | 1 | 1 1.0|
Turbinate, Inflammation, Chronic, | | |
Multifocal | 2 2 2 2 3 4 2 3 2 1 2 2 1 1 1| 29 1.8|
Turbinate, Ulcer, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 6| 4| 5| 5| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 7| 4| 7| 7| 7| 6| |
DAY ON TEST | 3| 2| 3| 0| 7| 3| 9| 9| 0| 9| 4| 5| 2| 8| 3| 2| 1| 3| 7| 0| 9| 0| 0| 3| 9| |
| 3| 9| 3| 5| 0| 6| 1| 8| 8| 3| 3| 3| 9| 1| 1| 2| 0| 8| 6| 8| 1| 9| 7| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic, Diffuse | 2 | 3 1.3|
Inflammation, Chronic, Focal | 1 | 2 1.0|
Inflammation, Chronic, Multifocal | 1 1 | 6 1.0|
Peritracheal Tissue, Abscess, | | |
Multifocal | 4 | 1 4.0|
Peritracheal Tissue, Inflammation, | | |
Acute, Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Multiple | | 1 3.0|
Inflammation, Chronic, Focal | | 1 2.0|
Inflammation, Chronic, Multifocal | 2 | 2 2.0|
Bilateral, Abscess, Multifocal | 2 | 1 2.0|
Bilateral, Glomerulosclerosis, | | |
Diffuse | 1 | 2 2.5|
Bilateral, Inflammation, Chronic, | | |
Diffuse | | 1 3.0|
Bilateral, Inflammation, Chronic, | | |
Multifocal | 2 2 2 1 1 1 2 1 2 2 1 3 1 1 1 1 2 1 2 2| 33 1.5|
Bilateral, Pelvis, Bacterium, | | |
Multifocal | 3 | 1 3.0|
Glomerulus, Renal Tubule, Amyloid | | |
Deposition, Diffuse | | 1 4.0|
Interstitial Tissue, Renal Tubule, | | |
Pigmentation, Multifocal | | 1 1.0|
Left, Hydronephrosis | 2 | 1 2.0|
Pelvis, Bacterium, Focal | | 1 3.0|
Pelvis, Bacterium, Multifocal | 2| 1 2.0|
Pelvis, Concretion, Multifocal | | 1 2.0|
Renal Tubule, Bacterium, Multifocal | 2 | 1 2.0|
Renal Tubule, Casts Protein, | | |
Multifocal | | 1 2.0|
Renal Tubule, Degeneration, Focal | 3 2 | 3 2.7|
Renal Tubule, Regeneration, Focal | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 6| 4| 5| 5| 7| 6| 6| 6| 7| 6| 7| 5| 6| 6| 6| 7| 4| 7| 7| 7| 6| |
DAY ON TEST | 3| 2| 3| 0| 7| 3| 9| 9| 0| 9| 4| 5| 2| 8| 3| 2| 1| 3| 7| 0| 9| 0| 0| 3| 9| |
| 3| 9| 3| 5| 0| 6| 1| 8| 8| 3| 3| 3| 9| 1| 1| 2| 0| 8| 6| 8| 1| 9| 7| 0| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Regeneration, | | |
Multifocal | 1 | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | M + + + + + + + + + + + + + + + + + + + + + + + A| 46 |
Abscess, Focal | 4 | 1 4.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 3 1 | 4 1.5|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 3 2 2 3 2 | 16 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 5| 6| 6| 7| 6| 3| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 6| 8| 2| 2| 2| 5| 1| 4| 3| 9| 1| 3| 3| 3| 2| 8| 9| 4| 2| 2| 0| 2| 5| 3| 2|
| 5| 0| 9| 9| 9| 0| 2| 2| 0| 3| 2| 0| 1| 0| 9| 9| 1| 5| 9| 9| 8| 6| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
375 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation, Focal | |
Periesophageal Tissue, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Gallbladder | M + + + + + + + + M M + + M + M + + + M + M A + M|
Infiltration Cellular, Diffuse, | |
Lymphocyte | |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Inflammation, Acute, Focal | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + A + + + + + + + + A + A + + A A + + +|
Ulcer, Diffuse | |
Wall, Abscess, Multifocal | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + A + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + M + + + + + M A + + + M + + +|
Inflammation, Acute, Focal | 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + A + + + + A + A + + A A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + A + + + A + + + + A + A + + A A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + A + + + + A + A + + A A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + A + + + A + + + + A + A + + A A + + +|
Peyer's Patch, Hyperplasia, Lymphoid,| |
Multifocal | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Multifocal | 1 2 2 2 1 2 1 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 |
Bile Duct, Infiltration Cellular, | |
Multifocal, Lymphocyte | 1 1 |
Bile Duct, Mineralization, Multifocal| |
Serosa, Inflammation, Acute, Focal | 4 |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Abscess, Multifocal | 4 4 4 4 4 4 |
Cyst, Single | 4 |
Inflammation, Granulomatous, | |
Multifocal | |
Pigmentation, Diffuse | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + M + + + + + + + + +|
Abscess, Multifocal | 4 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 5| 6| 6| 7| 6| 3| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 6| 8| 2| 2| 2| 5| 1| 4| 3| 9| 1| 3| 3| 3| 2| 8| 9| 4| 2| 2| 0| 2| 5| 3| 2|
| 5| 0| 9| 9| 9| 0| 2| 2| 0| 3| 2| 0| 1| 0| 9| 9| 1| 5| 9| 9| 8| 6| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
375 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Acute, Diffuse | |
Inflammation, Acute, Focal | 3 |
Inflammation, Chronic, Diffuse | 2 |
Inflammation, Chronic, Focal | 1 3 |
Inflammation, Chronic, Multifocal | 2 |
Duct, Inflammation, Chronic, Focal | |
Duct, Inflammation, Chronic, | |
Multifocal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + M + + + + + + + + + M M M + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 1 1 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + M + + + + + + + + + + + + + + + M + M + +|
Abscess, Focal | 2 |
Acanthosis, Focal | 2 3 |
Cyst Epithelial Inclusion, Focal | 1 |
Hyperkeratosis, Focal | 2 2 3|
Hyperplasia, Basal Cell | |
Inflammation, Chronic, Focal | 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Inflammation, Acute, Focal | 1 |
Inflammation, Acute, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic, Focal | 2 3 |
Atrium Left, Thrombosis | 3|
Epicardium, Inflammation, Chronic, | |
Focal | |
Myocardium, Inflammation, Acute, | |
Diffuse | 3 |
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 |
Pericardium, Inflammation, Chronic, | |
Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Capsule, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 5| 6| 6| 7| 6| 3| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 6| 8| 2| 2| 2| 5| 1| 4| 3| 9| 1| 3| 3| 3| 2| 8| 9| 4| 2| 2| 0| 2| 5| 3| 2|
| 5| 0| 9| 9| 9| 0| 2| 2| 0| 3| 2| 0| 1| 0| 9| 9| 1| 5| 9| 9| 8| 6| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
375 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation, | |
Focal | 2 |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Hypertrophy, Focal | 3 |
Bilateral, Hematopoietic Cell | |
Proliferation, Diffuse | 3 |
Bilateral, Hematopoietic Cell | |
Proliferation, Multifocal | 2 1 |
Bilateral, Vacuolization Cytoplasmic,| |
Diffuse | 2 |
Bilateral, Spindle Cell, Hyperplasia,| |
Diffuse | 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 |
Bilateral, Spindle Cell, Hyperplasia,| |
Multifocal | 2 2 2 2 |
Spindle Cell, Hyperplasia, Diffuse | 2 2 |
Spindle Cell, Hyperplasia, Multifocal| 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hematopoietic Cell Proliferation, | |
Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + M + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M M + M M + M + M M M + + + + M M + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hypertrophy, Focal | |
Craniopharyngeal Duct, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + M + + + M + + + + + + + + + + + + + +|
Hyperplasia, Multifocal | 3 |
Inflammation, Chronic, Focal | 2 |
Ultimobranchial Cyst | X X X X X X X X X|
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + M + + + + M + + +|
Abscess, Multifocal | 4 4 4 4 |
Cyst, Single | 3 3 |
Mineralization, Focal | |
Bilateral, Abscess, Multifocal | 4 4 |
Bilateral, Cyst, Multiple | 4 |
Germinal Epithelium, Hyperplasia, | |
Focal | 3 |
Periovarian Tissue, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 5| 6| 6| 7| 6| 3| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 6| 8| 2| 2| 2| 5| 1| 4| 3| 9| 1| 3| 3| 3| 2| 8| 9| 4| 2| 2| 0| 2| 5| 3| 2|
| 5| 0| 9| 9| 9| 0| 2| 2| 0| 3| 2| 0| 1| 0| 9| 9| 1| 5| 9| 9| 8| 6| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
375 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Chronic, Diffuse | |
__________________________________________________________________________|
Oviduct | + |
Inflammation, Acute, Diffuse | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Focal | 3 |
Abscess, Multifocal | 4 4 |
Dilatation | 3 3 |
Inflammation, Acute, Diffuse | 1 2 |
Endometrium, Edema, Diffuse | |
Endometrium, Hyperplasia, Cystic, | |
Diffuse | 2 1 2 2 2 3 2 2 2 2|
Endometrium, Hyperplasia, Cystic, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia, Diffuse | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + + + + + + A + + + + A + + + +|
Iliac, Infiltration Cellular, | |
Diffuse, Plasma Cell | 3 |
Mediastinal, Abscess, Multifocal | |
Mediastinal, Hyperplasia, Diffuse, | |
Lymphoid | |
Renal, Infiltration Cellular, | |
Diffuse, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + +|
Hyperplasia, Focal, Lymphoid | |
Hyperplasia, Lymphoid, Multifocal | 2 1 2 |
Infiltration Cellular, Diffuse, | |
Plasma Cell | 1 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + A + + + + A + + + +|
Hematopoietic Cell Proliferation, | |
Multifocal | 1 |
Hyperplasia, Diffuse, Lymphoid | |
Hyperplasia, Diffuse, Re Cell | 1 |
Hyperplasia, Lymphoid, Multifocal | 1 2 |
Infiltration Cellular, Diffuse, | |
Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Diffuse | 2 2 3 3 3 3 2 2 |
Hyperplasia, Diffuse, Lymphoid | |
Hyperplasia, Lymphoid, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 5| 6| 6| 7| 6| 3| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 6| 8| 2| 2| 2| 5| 1| 4| 3| 9| 1| 3| 3| 3| 2| 8| 9| 4| 2| 2| 0| 2| 5| 3| 2|
| 5| 0| 9| 9| 9| 0| 2| 2| 0| 3| 2| 0| 1| 0| 9| 9| 1| 5| 9| 9| 8| 6| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
375 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation, Diffuse | 1 |
Capsule, Inflammation, Chronic, Focal| 4 |
__________________________________________________________________________|
Thymus | M + + + + M + + + M + + + + + + M + + + + + + + +|
Abscess, Focal | 4 |
Atrophy, Diffuse | 3 3 4 3 2 4 2 4 3 3|
Hyperplasia, Focal, Lymphoid | |
Mediastinum, Abscess, Multifocal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M M + + + + + + + + + + + + + + + M + +|
Hyperplasia, Diffuse | 1 1 1 2 1 1 1|
Inflammation, Acute | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + +|
Acanthosis, Diffuse | 1 |
Acanthosis, Multifocal | 1 |
Hyperkeratosis, Diffuse | 1 |
Hyperkeratosis, Focal | 1 |
Hyperkeratosis, Multifocal | |
Inflammation, Chronic, Diffuse | 1 1 |
Inflammation, Chronic, Focal | |
Inflammation, Chronic, Multifocal | |
Hair Follicle, Atrophy, Diffuse | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fracture Healed | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + M + + + + + + + + + + + + + +|
Bilateral, Thalamus, Mineralization, | |
Multifocal | 1 1 1 1 1 1 1 1 1 1 |
Meninges, Cerebrum, Abscess, | |
Multifocal | |
Thalamus, Hemorrhage, Multifocal | |
Thalamus, Mineralization, Focal | 1 1 |
Thalamus, Mineralization, Multifocal | 1 1 |
Ventricle, Abscess, Multifocal | 4 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Multifocal | |
Hemorrhage, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 5| 6| 6| 7| 6| 3| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 6| 8| 2| 2| 2| 5| 1| 4| 3| 9| 1| 3| 3| 3| 2| 8| 9| 4| 2| 2| 0| 2| 5| 3| 2|
| 5| 0| 9| 9| 9| 0| 2| 2| 0| 3| 2| 0| 1| 0| 9| 9| 1| 5| 9| 9| 8| 6| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
375 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | |
Peribronchial, Infiltration Cellular,| |
Diffuse, Lymphocyte | 3 |
Peribronchial, Infiltration Cellular,| |
Multifocal, Lymphocyte | 3 3 2 2 1 2 2 2 2 2 2 1 1 |
Perivascular, Infiltration Cellular, | |
Multifocal, Lymphocyte | 2 2 2 3 1 1 3 1 3 1 1 3 2 |
Pleura, Inflammation, Chronic, | |
Diffuse | |
__________________________________________________________________________|
Nose | + + + + + + + + + + M + + + + + + + + + + + + + +|
Foreign Body | 1 1 2 1 3 2 1 1 1 1 1 2 1 2 2 2 2 2 3 1|
Glands, Hyperplasia | 1 2 3 2 3 2 1 1 3 2 1 2 2 3 2 2 2 2 2 2 2 2 3|
Olfactory Epithelium, Atrophy | 3 3 3 3 3 3 1 3 3 3 2 3 4 3 3 3 3 3 3 2 3 3 3 3|
Turbinate, Exudate | 2 3 2 1 2 3 2 1 2 |
Turbinate, Hemorrhage, Diffuse | 3 |
Turbinate, Hemorrhage, Multifocal | 3 |
Turbinate, Inflammation, Acute, | |
Multifocal | 1 1 1 1 1 1 1 1 1 |
Turbinate, Inflammation, Chronic, | |
Diffuse | 2 3 3 |
Turbinate, Inflammation, Chronic, | |
Focal | 1 2 2|
Turbinate, Inflammation, Chronic, | |
Multifocal | 3 3 1 2 2 1 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Diffuse | 2 |
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic, Multifocal | 1 1 |
Peritracheal Tissue, Inflammation, | |
Chronic, Diffuse | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Inflammation, Chronic, Multifocal | 1 1 2 1 1 |
Bilateral, Glomerulosclerosis, | |
Diffuse | |
Bilateral, Hematopoietic Cell | |
Proliferation, Diffuse | 2 |
Bilateral, Inflammation, Chronic, | |
Multifocal | 1 2 1 1 3 1 2 2 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 5| 6| 6| 7| 6| 3| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 6| 8| 2| 2| 2| 5| 1| 4| 3| 9| 1| 3| 3| 3| 2| 8| 9| 4| 2| 2| 0| 2| 5| 3| 2|
| 5| 0| 9| 9| 9| 0| 2| 2| 0| 3| 2| 0| 1| 0| 9| 9| 1| 5| 9| 9| 8| 6| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
375 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Bilateral, Cortex, Abscess, | |
Multifocal | |
Bilateral, Renal Tubule, Bacterium, | |
Multifocal | |
Bilateral, Renal Tubule, Casts | |
Protein, Multifocal | |
Bilateral, Renal Tubule, | |
Pigmentation, Multifocal | 3 |
Bilateral, Renal Tubule, | |
Regeneration, Multifocal | |
Capsule, Interstitial Tissue, | |
Inflammation, Chronic | |
Pelvis, Bacterium, Multifocal | |
Renal Tubule, Degeneration, | |
Multifocal | |
Renal Tubule, Regeneration, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + I + + + + + + + A + A + + M + + + +|
Abscess, Focal | 1 |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 1 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 1 2 2 1 1 2 2 2 |
Serosa, Inflammation, Chronic, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 6| 7| 5| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 2| 2| 0| 3| 3| 8| 7| 3| 9| 2| 2| 3| 2| 3| |
| 2| 1| 1| 0| 0| 1| 1| 1| 1| 0| 9| 9| 9| 7| 0| 5| 2| 3| 1| 7| 5| 9| 0| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
375 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Perforation, Focal | 4 | 1 4.0|
Periesophageal Tissue, Inflammation, | | |
Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | M M + + + + + + + + A + + M + + + + + A + M + M +| 34 |
Infiltration Cellular, Diffuse, | | |
Lymphocyte | 2 | 1 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 3 2 | 2 2.5|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
Inflammation, Acute, Focal | 1 1 | 3 1.3|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
Ulcer, Diffuse | 4 | 1 4.0|
Wall, Abscess, Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + M| 45 |
Inflammation, Acute, Focal | 1 1 1 1 1 1 1 1 1 1 | 15 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + A + + A A + + + +| 39 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A A + + A + + + +| 40 |
Peyer's Patch, Hyperplasia, Lymphoid,| | |
Multifocal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 1 1 1 1 1| 12 1.3|
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2 | 4 1.5|
Bile Duct, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 1 2 | 4 1.3|
Bile Duct, Mineralization, Multifocal| 2 | 1 2.0|
Serosa, Inflammation, Acute, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 12 |
Abscess, Multifocal | 4 4 | 8 4.0|
Cyst, Single | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 6| 7| 5| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 2| 2| 0| 3| 3| 8| 7| 3| 9| 2| 2| 3| 2| 3| |
| 2| 1| 1| 0| 0| 1| 1| 1| 1| 0| 9| 9| 9| 7| 0| 5| 2| 3| 1| 7| 5| 9| 0| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
375 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Granulomatous, | | |
Multifocal | 3 | 1 3.0|
Pigmentation, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess, Multifocal | | 1 4.0|
Inflammation, Acute, Diffuse | 3 | 1 3.0|
Inflammation, Acute, Focal | | 1 3.0|
Inflammation, Chronic, Diffuse | | 1 2.0|
Inflammation, Chronic, Focal | 2 1 1 | 5 1.6|
Inflammation, Chronic, Multifocal | | 1 2.0|
Duct, Inflammation, Chronic, Focal | 1 | 1 1.0|
Duct, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + +| 45 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 1 | 5 1.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 1 1 | 8 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Abscess, Focal | | 1 2.0|
Acanthosis, Focal | | 2 2.5|
Cyst Epithelial Inclusion, Focal | | 1 1.0|
Hyperkeratosis, Focal | | 3 2.3|
Hyperplasia, Basal Cell | 4 | 1 4.0|
Inflammation, Chronic, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute, Focal | | 1 1.0|
Inflammation, Acute, Multifocal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic, Focal | 3 | 3 2.7|
Atrium Left, Thrombosis | | 1 3.0|
Epicardium, Inflammation, Chronic, | | |
Focal | 2 1 | 2 1.5|
Myocardium, Inflammation, Acute, | | |
Diffuse | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 6| 7| 5| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 2| 2| 0| 3| 3| 8| 7| 3| 9| 2| 2| 3| 2| 3| |
| 2| 1| 1| 0| 0| 1| 1| 1| 1| 0| 9| 9| 9| 7| 0| 5| 2| 3| 1| 7| 5| 9| 0| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
375 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Myocardium, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
Pericardium, Inflammation, Chronic, | | |
Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Inflammation, Chronic, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation, | | |
Focal | | 1 2.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 1 | 1 1.0|
Hypertrophy, Focal | | 1 3.0|
Bilateral, Hematopoietic Cell | | |
Proliferation, Diffuse | | 1 3.0|
Bilateral, Hematopoietic Cell | | |
Proliferation, Multifocal | | 2 1.5|
Bilateral, Vacuolization Cytoplasmic,| | |
Diffuse | | 1 2.0|
Bilateral, Spindle Cell, Hyperplasia,| | |
Diffuse | 3 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2| 33 2.1|
Bilateral, Spindle Cell, Hyperplasia,| | |
Multifocal | 2 1 2 1 2 2 | 10 1.8|
Spindle Cell, Hyperplasia, Diffuse | 2 2 | 4 2.0|
Spindle Cell, Hyperplasia, Multifocal| | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M + + M + M M + M + M M + + + + + M + M M| 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hypertrophy, Focal | 1 | 1 1.0|
Craniopharyngeal Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | M + + + + + + + + + + + + + M + + + + + + + + + +| 46 |
Hyperplasia, Multifocal | | 1 3.0|
Inflammation, Chronic, Focal | | 1 2.0|
Ultimobranchial Cyst | X X X X X X X X X| 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 6| 7| 5| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 2| 2| 0| 3| 3| 8| 7| 3| 9| 2| 2| 3| 2| 3| |
| 2| 1| 1| 0| 0| 1| 1| 1| 1| 0| 9| 9| 9| 7| 0| 5| 2| 3| 1| 7| 5| 9| 0| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
375 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicle, Cyst | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Abscess, Multifocal | 4 4 4 | 7 4.0|
Cyst, Single | 4 3 | 4 3.3|
Mineralization, Focal | 2 2 | 2 2.0|
Bilateral, Abscess, Multifocal | | 2 4.0|
Bilateral, Cyst, Multiple | | 1 4.0|
Germinal Epithelium, Hyperplasia, | | |
Focal | | 1 3.0|
Periovarian Tissue, Inflammation, | | |
Chronic, Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Oviduct | | 1 |
Inflammation, Acute, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess, Focal | | 1 3.0|
Abscess, Multifocal | | 2 4.0|
Dilatation | 3 3 4 3 3 | 7 3.1|
Inflammation, Acute, Diffuse | 1 | 3 1.3|
Endometrium, Edema, Diffuse | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic, | | |
Diffuse | 1 2 3 2 1 2 2 2 3 2 1 2 1 1 2 2| 26 1.9|
Endometrium, Hyperplasia, Cystic, | | |
Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myeloid Cell, Hyperplasia, Diffuse | 1 1 2 | 4 1.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Iliac, Infiltration Cellular, | | |
Diffuse, Plasma Cell | | 1 3.0|
Mediastinal, Abscess, Multifocal | 4 | 1 4.0|
Mediastinal, Hyperplasia, Diffuse, | | |
Lymphoid | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 6| 7| 5| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 2| 2| 0| 3| 3| 8| 7| 3| 9| 2| 2| 3| 2| 3| |
| 2| 1| 1| 0| 0| 1| 1| 1| 1| 0| 9| 9| 9| 7| 0| 5| 2| 3| 1| 7| 5| 9| 0| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
375 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Infiltration Cellular, | | |
Diffuse, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + +| 15 |
Hyperplasia, Focal, Lymphoid | 1 | 1 1.0|
Hyperplasia, Lymphoid, Multifocal | 3 2 2 1 2| 8 1.9|
Infiltration Cellular, Diffuse, | | |
Plasma Cell | 2 2 3 3 1| 7 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 1.0|
Hyperplasia, Diffuse, Lymphoid | 3 | 1 3.0|
Hyperplasia, Diffuse, Re Cell | | 1 1.0|
Hyperplasia, Lymphoid, Multifocal | 1 | 3 1.3|
Infiltration Cellular, Diffuse, | | |
Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation, | | |
Diffuse | 1 1 2 1 3 3 2 1 2 2 | 18 2.1|
Hyperplasia, Diffuse, Lymphoid | 2 2 3 | 3 2.3|
Hyperplasia, Lymphoid, Multifocal | 1 | 2 1.0|
Pigmentation, Diffuse | 1 1 | 3 1.0|
Capsule, Inflammation, Chronic, Focal| 4 | 2 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + M + M + + + M + + + + + + +| 42 |
Abscess, Focal | | 1 4.0|
Atrophy, Diffuse | 2 3 3 | 13 3.0|
Hyperplasia, Focal, Lymphoid | 2 | 1 2.0|
Mediastinum, Abscess, Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 46 |
Hyperplasia, Diffuse | 1 | 8 1.1|
Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + +| 34 |
Acanthosis, Diffuse | 1 | 2 1.0|
Acanthosis, Multifocal | 1 1 | 3 1.0|
Hyperkeratosis, Diffuse | | 1 1.0|
Hyperkeratosis, Focal | | 1 1.0|
Hyperkeratosis, Multifocal | 1 1 | 2 1.0|
Inflammation, Chronic, Diffuse | 1 2 1| 5 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 6| 7| 5| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 2| 2| 0| 3| 3| 8| 7| 3| 9| 2| 2| 3| 2| 3| |
| 2| 1| 1| 0| 0| 1| 1| 1| 1| 0| 9| 9| 9| 7| 0| 5| 2| 3| 1| 7| 5| 9| 0| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
375 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic, Focal | 1 | 1 1.0|
Inflammation, Chronic, Multifocal | 1 | 1 1.0|
Hair Follicle, Atrophy, Diffuse | 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femur, Fracture Healed | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, Thalamus, Mineralization, | | |
Multifocal | 1 1 1 1 1 2 2 | 17 1.1|
Meninges, Cerebrum, Abscess, | | |
Multifocal | 4 | 1 4.0|
Thalamus, Hemorrhage, Multifocal | 3 | 1 3.0|
Thalamus, Mineralization, Focal | 1 | 3 1.0|
Thalamus, Mineralization, Multifocal | 1 1 1 1 | 6 1.0|
Ventricle, Abscess, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess, Multifocal | 2 3 | 2 2.5|
Hemorrhage, Diffuse | 4 | 1 4.0|
Alveolar Epithelium, Hyperplasia | 3 | 1 3.0|
Peribronchial, Infiltration Cellular,| | |
Diffuse, Lymphocyte | | 1 3.0|
Peribronchial, Infiltration Cellular,| | |
Multifocal, Lymphocyte | 1 3 2 2 2 2 3 2 2 2 1 1 1 1 1 | 28 1.8|
Perivascular, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 2 2 1 3 3 1 2 1 3 1| 23 1.9|
Pleura, Inflammation, Chronic, | | |
Diffuse | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 1 2 1 1 1 2 1 1 3 2 1 2 2 1 1| 35 1.5|
Glands, Hyperplasia | 2 2 1 3 2 1 3 2 3 1 1 2 2 2 2 1 2 2 3 3 3 3| 45 2.1|
Olfactory Epithelium, Atrophy | 3 3 3 3 4 2 3 3 4 1 3 4 3 3 2 3 4 4 3 3 2 3| 46 2.9|
Turbinate, Exudate | 2 1 2 2 2 1 1 2 2 3 2 1 1| 22 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 6| 7| 5| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 2| 2| 0| 3| 3| 8| 7| 3| 9| 2| 2| 3| 2| 3| |
| 2| 1| 1| 0| 0| 1| 1| 1| 1| 0| 9| 9| 9| 7| 0| 5| 2| 3| 1| 7| 5| 9| 0| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
375 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Turbinate, Hemorrhage, Diffuse | 3 | 2 3.0|
Turbinate, Hemorrhage, Multifocal | | 1 3.0|
Turbinate, Inflammation, Acute, | | |
Multifocal | 1 1 1 2 1 1 1 1 1 1 1 1 1| 22 1.0|
Turbinate, Inflammation, Chronic, | | |
Diffuse | 2 3 3 2 2 3 2| 10 2.5|
Turbinate, Inflammation, Chronic, | | |
Focal | 1 | 4 1.5|
Turbinate, Inflammation, Chronic, | | |
Multifocal | 3 2 2 2 1 2 3 1 | 17 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Diffuse | 2 1 | 3 1.7|
Inflammation, Chronic, Focal | 1 1 1 1| 5 1.0|
Inflammation, Chronic, Multifocal | 1 1 1 1 1 | 7 1.0|
Peritracheal Tissue, Inflammation, | | |
Chronic, Diffuse | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | 1 1| 2 1.0|
Inflammation, Chronic, Multifocal | 1 1 1 1 1 | 10 1.1|
Bilateral, Glomerulosclerosis, | | |
Diffuse | 1 | 1 1.0|
Bilateral, Hematopoietic Cell | | |
Proliferation, Diffuse | | 1 2.0|
Bilateral, Inflammation, Chronic, | | |
Multifocal | 1 2 2 2 3 2 1 2 2 1 | 21 1.7|
Bilateral, Cortex, Abscess, | | |
Multifocal | 3 | 1 3.0|
Bilateral, Renal Tubule, Bacterium, | | |
Multifocal | 3 | 1 3.0|
Bilateral, Renal Tubule, Casts | | |
Protein, Multifocal | 1 | 1 1.0|
Bilateral, Renal Tubule, | | |
Pigmentation, Multifocal | 2 | 2 2.5|
Bilateral, Renal Tubule, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 4| 5| 6| 7| 5| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 2| 2| 0| 3| 3| 8| 7| 3| 9| 2| 2| 3| 2| 3| |
| 2| 1| 1| 0| 0| 1| 1| 1| 1| 0| 9| 9| 9| 7| 0| 5| 2| 3| 1| 7| 5| 9| 0| 9| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
375 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Regeneration, Multifocal | 2 | 1 2.0|
Capsule, Interstitial Tissue, | | |
Inflammation, Chronic | 3 | 1 3.0|
Pelvis, Bacterium, Multifocal | 2 | 1 2.0|
Renal Tubule, Degeneration, | | |
Multifocal | 1 | 1 1.0|
Renal Tubule, Regeneration, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Abscess, Focal | | 1 1.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 1 1 | 6 1.2|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 1| 22 1.8|
Serosa, Inflammation, Chronic, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 2| 3| 2| 9| 4| 3| 3| 2| 3| 7| 3| 3| 2| 2| 1| 3| 2| 3| 2|
| 9| 5| 0| 0| 0| 9| 9| 0| 9| 2| 9| 1| 0| 9| 1| 4| 1| 1| 9| 9| 0| 1| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
750 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation, Focal | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + A M + M + + + + + + + M + + + +|
Infiltration Cellular, Diffuse, | |
Lymphocyte | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Acute, Diffuse | |
Inflammation, Acute, Focal | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Lymphoid Nodule, Hyperplasia, Focal, | |
Lymphoid | 2 |
Lymphoid Nodule, Hyperplasia, | |
Lymphoid, Multifocal | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + M + + M + + + + + + + M + + +|
Inflammation, Acute, Focal | 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Diffuse, | |
Lymphoid | 3 |
Peyer's Patch, Hyperplasia, Focal, | |
Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | |
Fatty Change, Diffuse | |
Hematopoietic Cell Proliferation, | |
Multifocal | 1 |
Hypertrophy, Focal | |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 |
Inflammation, Acute, Multifocal | 1 |
Bile Duct, Infiltration Cellular, | |
Multifocal, Lymphocyte | |
Hepatocyte, Focal Cellular Change | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Acute, Multifocal | 4 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 2| 3| 2| 9| 4| 3| 3| 2| 3| 7| 3| 3| 2| 2| 1| 3| 2| 3| 2|
| 9| 5| 0| 0| 0| 9| 9| 0| 9| 2| 9| 1| 0| 9| 1| 4| 1| 1| 9| 9| 0| 1| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
750 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Fat, Necrosis, Multifocal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | |
Atrophy, Focal | 4 2 |
Inflammation, Chronic, Diffuse | 3 |
Inflammation, Chronic, Focal | |
Inflammation, Chronic, Multifocal | 1 |
Necrosis, Focal | 4 |
Duct, Cyst, Single | |
Duct, Dilatation | |
Duct, Inflammation, Chronic, Focal | |
Duct, Inflammation, Chronic, | |
Multifocal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 1 1 1 1 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 3 2 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | M + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Focal | 2 |
Abscess, Multifocal | |
Acanthosis, Focal | 2 2 2 3 |
Cyst Epithelial Inclusion, Focal | 1 |
Hyperkeratosis, Focal | |
Inflammation, Acute, Focal | 2 |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium Left, Bacterium, Focal | |
Atrium Left, Thrombosis | |
Myocardium, Inflammation, Chronic, | |
Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | |
Cyst, Single | |
Hematopoietic Cell Proliferation, | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 2| 3| 2| 9| 4| 3| 3| 2| 3| 7| 3| 3| 2| 2| 1| 3| 2| 3| 2|
| 9| 5| 0| 0| 0| 9| 9| 0| 9| 2| 9| 1| 0| 9| 1| 4| 1| 1| 9| 9| 0| 1| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
750 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Multifocal | |
Hypertrophy, Focal | |
Bilateral, Vacuolization Cytoplasmic,| |
Diffuse | 3 |
Bilateral, Spindle Cell, Hyperplasia,| |
Diffuse | 2 2 2 2 3 2 2 2 2 2 3 1 2 2 2 3 2 2 3|
Bilateral, Spindle Cell, Hyperplasia,| |
Multifocal | 2 2 1 2 |
Spindle Cell, Hyperplasia, Diffuse | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M + M + + M + + M + M M M M M + M + M M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hypertrophy, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X X |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | 4 |
Cyst, Single | 2 3 2 1 |
Bilateral, Abscess, Multifocal | 4 |
Bilateral, Cyst, Multiple | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 2 2 4 3 |
Endometrium, Hyperplasia, Cystic, | |
Diffuse | 1 2 1 2 2 2 2 2 2 1 1 2 2 2 2|
Endometrium, Hyperplasia, Cystic, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia, Diffuse | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia, Diffuse, Lymphoid | 4 |
Hyperplasia, Diffuse, Re Cell | |
Hyperplasia, Lymphoid, Multifocal | 2 2 1 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 2| 3| 2| 9| 4| 3| 3| 2| 3| 7| 3| 3| 2| 2| 1| 3| 2| 3| 2|
| 9| 5| 0| 0| 0| 9| 9| 0| 9| 2| 9| 1| 0| 9| 1| 4| 1| 1| 9| 9| 0| 1| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
750 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Diffuse | 2 2 2 1 |
Hyperplasia, Diffuse, Lymphoid | 2 2 1 3 2 1 1 |
Hyperplasia, Lymphoid, Multifocal | 1 1 |
Hyperplasia, Multifocal, Re Cell | |
Pigmentation, Diffuse | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M M + + +|
Atrophy, Diffuse | 2 4 4 2 |
Hyperplasia, Focal, Lymphoid | |
Hyperplasia, Focal, Re Cell | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + I + + + + + + M + M + + + + + + + + + + + + + +|
Hyperplasia, Diffuse | |
__________________________________________________________________________|
Skin | + + + + + + + + + + +|
Acanthosis, Diffuse | |
Acanthosis, Focal | 1 |
Acanthosis, Multifocal | 1 1 2 1 1 1 1 1|
Hyperkeratosis, Diffuse | |
Inflammation, Acute, Multifocal | 2 |
Inflammation, Chronic, Diffuse | 1 |
Inflammation, Chronic, Multifocal | 1 |
Ulcer, Focal | |
Hair Follicle, Acanthosis, Diffuse | 1 |
Hair Follicle, Atrophy, Diffuse | 1 1 2 2 1 |
Hair Follicle, Atrophy, Multifocal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Thalamus, Mineralization, | |
Multifocal | 1 1 1 1 1 1 |
Thalamus, Mineralization, Focal | 1 |
Thalamus, Mineralization, Multifocal | 1 1 1 1 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolus, Inflammation, Acute, Focal | |
Peribronchial, Infiltration Cellular,| |
Diffuse, Lymphocyte | 3 |
Peribronchial, Infiltration Cellular,| |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 2| 3| 2| 9| 4| 3| 3| 2| 3| 7| 3| 3| 2| 2| 1| 3| 2| 3| 2|
| 9| 5| 0| 0| 0| 9| 9| 0| 9| 2| 9| 1| 0| 9| 1| 4| 1| 1| 9| 9| 0| 1| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
750 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Multifocal, Lymphocyte | 1 2 1 2 2 1 1 3 3 2 1 1 3 2 2 1 1 1|
Peribronchiolar, Infiltration | |
Cellular, Multifocal, Lymphocyte | 1 |
Perivascular, Infiltration Cellular, | |
Diffuse, Lymphocyte | 3 |
Perivascular, Infiltration Cellular, | |
Multifocal, Lymphocyte | 1 1 1 |
Pleura, Foreign Body, Focal | |
Pleura, Inflammation, Acute, | |
Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 2 2 1 1 2 2 1 2 2 1 1 1 |
Hyperplasia, Focal, Lymphoid | |
Glands, Hyperplasia | 3 3 3 2 3 3 4 4 3 3 3 2 4 3 4 3 3 4 2 3 3 2 4 4 3|
Olfactory Epithelium, Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 3 3 3 3 4 3 3 3 3|
Turbinate, Exudate | 2 2 2 2 2 1 3 1 2 |
Turbinate, Fungus, Focal | 4 |
Turbinate, Inflammation, Acute, | |
Diffuse | 2 |
Turbinate, Inflammation, Acute, Focal| 4 |
Turbinate, Inflammation, Acute, | |
Multifocal | 2 2 2 1 1 2 1 2 1 2 1 1 1 1 1 1 1 1|
Turbinate, Inflammation, Chronic, | |
Diffuse | 3 |
Turbinate, Inflammation, Chronic, | |
Focal | 1 |
Turbinate, Inflammation, Chronic, | |
Multifocal | 1 2 2 2 2 3 3 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 1 |
Inflammation, Chronic, Diffuse | |
Inflammation, Chronic, Focal | |
Inflammation, Chronic, Multifocal | 1 1 1 1 1 1 |
Peritracheal Tissue, Foreign Body, | |
Focal | |
Peritracheal Tissue, Hemorrhage, | |
Focal | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | 4 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 2| 3| 2| 9| 4| 3| 3| 2| 3| 7| 3| 3| 2| 2| 1| 3| 2| 3| 2|
| 9| 5| 0| 0| 0| 9| 9| 0| 9| 2| 9| 1| 0| 9| 1| 4| 1| 1| 9| 9| 0| 1| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
750 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic, Multifocal | 2 1 1 1 1 |
Bilateral, Inflammation, Chronic, | |
Multifocal | 1 2 2 2 1 1 2 1 1 2 2 |
Bilateral, Renal Tubule, | |
Mineralization, Multifocal | 1 |
Pelvis, Bacterium, Multifocal | 1 |
__________________________________________________________________________|
Ureter | + |
Dilatation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 1 1 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 3 1 2 2 1 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 3| 7| 1| 3| 3| 9| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 2| 3| 3| |
| 1| 1| 9| 9| 0| 0| 5| 1| 0| 0| 9| 9| 9| 0| 0| 1| 1| 0| 1| 9| 3| 0| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
750 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Perforation, Focal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + + A + + + + + + + + + + A + M + +| 42 |
Infiltration Cellular, Diffuse, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 2 1.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 1 1.0|
Inflammation, Acute, Diffuse | 2 | 1 2.0|
Inflammation, Acute, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + M + + + A + + A + + + + + + + + + + + + + + +| 46 |
Lymphoid Nodule, Hyperplasia, Focal, | | |
Lymphoid | | 1 2.0|
Lymphoid Nodule, Hyperplasia, | | |
Lymphoid, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + M + + + + + + + + + + + +| 45 |
Inflammation, Acute, Focal | 1 1 1 1 1 1 1 1 1 1 1 1| 22 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + A + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + A + + + + + + + + + + A + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + A + + + +| 47 |
Peyer's Patch, Hyperplasia, Diffuse, | | |
Lymphoid | | 1 3.0|
Peyer's Patch, Hyperplasia, Focal, | | |
Lymphoid | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Multifocal | 2 | 1 2.0|
Fatty Change, Diffuse | 3 | 1 3.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 1.0|
Hypertrophy, Focal | 1 | 1 1.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 | 1 1.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 1 | 4 1.5|
Inflammation, Acute, Multifocal | 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 3| 7| 1| 3| 3| 9| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 2| 3| 3| |
| 1| 1| 9| 9| 0| 0| 5| 1| 0| 0| 9| 9| 9| 0| 0| 1| 1| 0| 1| 9| 3| 0| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
750 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Bile Duct, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 1 1 1 1 1 | 5 1.0|
Hepatocyte, Focal Cellular Change | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Inflammation, Acute, Multifocal | | 1 4.0|
Fat, Necrosis, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Atrophy, Diffuse | 4 | 1 4.0|
Atrophy, Focal | 3 | 3 3.0|
Inflammation, Chronic, Diffuse | | 1 3.0|
Inflammation, Chronic, Focal | 1 1 | 2 1.0|
Inflammation, Chronic, Multifocal | | 1 1.0|
Necrosis, Focal | | 1 4.0|
Duct, Cyst, Single | 3 2 | 2 2.5|
Duct, Dilatation | 3 | 1 3.0|
Duct, Inflammation, Chronic, Focal | 2 1 | 2 1.5|
Duct, Inflammation, Chronic, | | |
Multifocal | 3 2 | 3 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 1 1 2 | 9 1.1|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 3 2 1 2 1 2 3 3| 17 1.8|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess, Focal | | 1 2.0|
Abscess, Multifocal | 2 | 1 2.0|
Acanthosis, Focal | 1 2 1 | 7 1.9|
Cyst Epithelial Inclusion, Focal | | 1 1.0|
Hyperkeratosis, Focal | 2 | 1 2.0|
Inflammation, Acute, Focal | | 1 2.0|
Inflammation, Chronic, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium Left, Bacterium, Focal | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 3| 7| 1| 3| 3| 9| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 2| 3| 3| |
| 1| 1| 9| 9| 0| 0| 5| 1| 0| 0| 9| 9| 9| 0| 0| 1| 1| 0| 1| 9| 3| 0| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
750 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Atrium Left, Thrombosis | X | 1 |
Myocardium, Inflammation, Chronic, | | |
Focal | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Multiple | 1 | 1 1.0|
Cyst, Single | 2 | 1 2.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 | 1 2.0|
Hypertrophy, Focal | 2 | 1 2.0|
Bilateral, Vacuolization Cytoplasmic,| | |
Diffuse | | 1 3.0|
Bilateral, Spindle Cell, Hyperplasia,| | |
Diffuse | 3 2 1 2 2 2 2 2 2 2 2 3 2 2 2 2 2 3 2 2| 39 2.1|
Bilateral, Spindle Cell, Hyperplasia,| | |
Multifocal | 2 2 2 | 7 1.9|
Spindle Cell, Hyperplasia, Diffuse | 2 | 3 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + I + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M + M + M M + + M + M + + M M + M + M M M M| 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Hypertrophy, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X X | 4 |
Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + M + + + + + M| 48 |
Cyst, Multiple | | 1 4.0|
Cyst, Single | 1 4 2 2 2 1 | 10 2.0|
Bilateral, Abscess, Multifocal | | 1 4.0|
Bilateral, Cyst, Multiple | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 2 2 2 4 2 2 | 14 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 3| 7| 1| 3| 3| 9| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 2| 3| 3| |
| 1| 1| 9| 9| 0| 0| 5| 1| 0| 0| 9| 9| 9| 0| 0| 1| 1| 0| 1| 9| 3| 0| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
750 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Hyperplasia, Cystic, | | |
Diffuse | 1 1 2 1 2 1 2 2 2 2 2 2| 27 1.7|
Endometrium, Hyperplasia, Cystic, | | |
Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myeloid Cell, Hyperplasia, Diffuse | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Hyperplasia, Diffuse, Lymphoid | 2 | 2 3.0|
Hyperplasia, Diffuse, Re Cell | 3 | 1 3.0|
Hyperplasia, Lymphoid, Multifocal | 2 2 2 2 1 1 1 | 14 1.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation, | | |
Diffuse | 1 2 3 | 7 1.9|
Hyperplasia, Diffuse, Lymphoid | 2 2 2 2 2 2 1 2 2| 16 1.8|
Hyperplasia, Lymphoid, Multifocal | 1 | 3 1.0|
Hyperplasia, Multifocal, Re Cell | 1 | 1 1.0|
Pigmentation, Diffuse | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M M + + + + + + + + + + + + + +| 46 |
Atrophy, Diffuse | 3 4 | 6 3.2|
Hyperplasia, Focal, Lymphoid | 2 2 | 2 2.0|
Hyperplasia, Focal, Re Cell | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + M M + + + + + + + + + M M + + + + +| 42 |
Hyperplasia, Diffuse | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Skin | + + + | 14 |
Acanthosis, Diffuse | 1 | 1 1.0|
Acanthosis, Focal | 1 | 2 1.0|
Acanthosis, Multifocal | | 8 1.1|
Hyperkeratosis, Diffuse | 1 | 1 1.0|
Inflammation, Acute, Multifocal | | 1 2.0|
Inflammation, Chronic, Diffuse | 3 | 2 2.0|
Inflammation, Chronic, Multifocal | | 1 1.0|
Ulcer, Focal | 3 | 1 3.0|
Hair Follicle, Acanthosis, Diffuse | | 1 1.0|
Hair Follicle, Atrophy, Diffuse | 2 | 6 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 3| 7| 1| 3| 3| 9| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 2| 3| 3| |
| 1| 1| 9| 9| 0| 0| 5| 1| 0| 0| 9| 9| 9| 0| 0| 1| 1| 0| 1| 9| 3| 0| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
750 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hair Follicle, Atrophy, Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Thalamus, Mineralization, | | |
Multifocal | 1 1 1 1 1 1 1 1 1 | 15 1.0|
Thalamus, Mineralization, Focal | 1 1 1 | 4 1.0|
Thalamus, Mineralization, Multifocal | 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolus, Inflammation, Acute, Focal | 1 | 1 1.0|
Peribronchial, Infiltration Cellular,| | |
Diffuse, Lymphocyte | | 1 3.0|
Peribronchial, Infiltration Cellular,| | |
Multifocal, Lymphocyte | 2 1 2 2 2 1 1 1 2 2 2 1 2 3 1 1 3| 35 1.7|
Peribronchiolar, Infiltration | | |
Cellular, Multifocal, Lymphocyte | 3 | 2 2.0|
Perivascular, Infiltration Cellular, | | |
Diffuse, Lymphocyte | | 1 3.0|
Perivascular, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 1 2 1 3 1 | 8 1.4|
Pleura, Foreign Body, Focal | 2 | 1 2.0|
Pleura, Inflammation, Acute, | | |
Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 1 1 2 1 1 1 2 2 1 1 1 2 1 1 1 2 1 2 1 1| 33 1.4|
Hyperplasia, Focal, Lymphoid | 3 | 1 3.0|
Glands, Hyperplasia | 4 3 4 3 2 2 2 4 4 3 3 4 4 4 4 4 3 3 3 4 4 4 3 4| 49 3.3|
Olfactory Epithelium, Atrophy | 3 3 3 3 3 3 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 49 3.1|
Turbinate, Exudate | 3 2 2 4 2 2 3 2 | 17 2.2|
Turbinate, Fungus, Focal | | 1 4.0|
Turbinate, Inflammation, Acute, | | |
Diffuse | 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 6| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 3| 7| 1| 3| 3| 9| 3| 2| 2| 3| 3| 3| 3| 3| 3| 2| 0| 3| 2| 3| 3| |
| 1| 1| 9| 9| 0| 0| 5| 1| 0| 0| 9| 9| 9| 0| 0| 1| 1| 0| 1| 9| 3| 0| 9| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
750 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Turbinate, Inflammation, Acute, Focal| | 1 4.0|
Turbinate, Inflammation, Acute, | | |
Multifocal | 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.2|
Turbinate, Inflammation, Chronic, | | |
Diffuse | 3 3 | 3 3.0|
Turbinate, Inflammation, Chronic, | | |
Focal | 2| 2 1.5|
Turbinate, Inflammation, Chronic, | | |
Multifocal | 1 1 1 2 2 2 1 | 16 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Focal | | 1 1.0|
Inflammation, Chronic, Diffuse | 1 | 1 1.0|
Inflammation, Chronic, Focal | 1 | 1 1.0|
Inflammation, Chronic, Multifocal | 1 1 1 1 | 10 1.0|
Peritracheal Tissue, Foreign Body, | | |
Focal | 2 | 1 2.0|
Peritracheal Tissue, Hemorrhage, | | |
Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst, Multiple | | 1 4.0|
Inflammation, Chronic, Focal | 1 1 1 | 4 1.0|
Inflammation, Chronic, Multifocal | 1 1 | 7 1.1|
Bilateral, Inflammation, Chronic, | | |
Multifocal | 2 2 3 1 1 2 1 2 2 1| 21 1.6|
Bilateral, Renal Tubule, | | |
Mineralization, Multifocal | | 1 1.0|
Pelvis, Bacterium, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Ureter | | 1 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + + A + + + +| 48 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 2 | 5 1.2|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 1 2 2 2 1 1 2| 19 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 8| 2| 3| 2| 9| 8| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 2|
| 7| 1| 0| 0| 7| 2| 0| 9| 9| 0| 0| 9| 1| 0| 0| 9| 0| 0| 1| 0| 0| 4| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + M A + + + + + + + + + M + + + + + M + + + +|
Infiltration Cellular, Diffuse, | |
Lymphocyte | 3 2 2|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Acute, Diffuse | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Cyst, Multiple | |
Infarct, Focal | |
Necrosis, Coagulative, Diffuse | |
Bile Duct, Infiltration Cellular, | |
Multifocal, Lymphocyte | 3 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Acute, Diffuse | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Focal | |
Atrophy, Focal | 2 |
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic, Multifocal | |
Necrosis, Focal | 1 |
Vacuolization Cytoplasmic, Multifocal| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 1 2 2 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 3 1 2 2 2 1 2 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + M M + + + + + + + + + + + + + + + + + + + + +|
Abscess, Focal | 2 2 1 |
Abscess, Multifocal | 1 |
Acanthosis, Focal | 3 3 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 8| 2| 3| 2| 9| 8| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 2|
| 7| 1| 0| 0| 7| 2| 0| 9| 9| 0| 0| 9| 1| 0| 0| 9| 0| 0| 1| 0| 0| 4| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acanthosis, Multifocal | 1 |
Cyst Epithelial Inclusion, Focal | 2 |
Inflammation, Chronic, Focal | 2 2 |
Inflammation, Chronic, Multifocal | |
Serosa, Inflammation, Acute, Diffuse | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + + + + +|
Artery, Adventitia, Inflammation, | |
Chronic, Multifocal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric Artery, Aorta, Adventitia,| |
Inflammation, Chronic, | |
Multifocal | |
Mesenteric Artery, Aorta, Media, | |
Hypertrophy, Multifocal | |
Mesenteric Artery, Renal Artery, | |
Adventitia, Inflammation, | |
Chronic, Multifocal | |
Mesenteric Artery, Renal Artery, | |
Media, Hypertrophy, Diffuse | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic, | |
Diffuse | |
Endocardium, Inflammation, Chronic, | |
Focal | 1 |
Epicardium, Inflammation, Acute, | |
Diffuse | |
Epicardium, Inflammation, Acute, | |
Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | |
Bilateral, Spindle Cell, Hyperplasia,| |
Focal | 1 |
Bilateral, Spindle Cell, Hyperplasia,| |
Multifocal | 1 2 2 1 1 2 2 1 1 1 2 2 1 1 1 |
Spindle Cell, Hyperplasia, Focal | 1 1 1 |
Spindle Cell, Hyperplasia, Multifocal| 1 2 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + M + + + + + + + M + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 8| 2| 3| 2| 9| 8| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 2|
| 7| 1| 0| 0| 7| 2| 0| 9| 9| 0| 0| 9| 1| 0| 0| 9| 0| 0| 1| 0| 0| 4| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Vacuolization Cytoplasmic, Diffuse | 1 |
__________________________________________________________________________|
Parathyroid Gland | M M + + M + + M M M + M + M + + M + + + + + M M M|
Infiltration Cellular, Focal, | |
Lymphocyte | |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + M + M + + + + + + + M + + + +|
Hypertrophy, Focal | |
Craniopharyngeal Duct, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
Ultimobranchial Cyst | X X X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular, Multifocal | |
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic, Multifocal | |
Vacuolization Cytoplasmic, Diffuse | |
Bilateral, Vacuolization Cytoplasmic,| |
Diffuse | 3 |
Bilateral, Vacuolization Cytoplasmic,| |
Multifocal | |
Serosa, Inflammation, Acute, Diffuse | |
__________________________________________________________________________|
Penis | |
Inflammation, Focal | |
__________________________________________________________________________|
Preputial Gland | + + + |
Abscess, Focal | 4 |
Abscess, Multifocal | 4 |
Dilatation | |
Inflammation, Chronic, Diffuse | |
Inflammation, Chronic, Multifocal | |
Bilateral, Dilatation | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + M|
Abscess, Multifocal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
Inflammation, Acute, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 8| 2| 3| 2| 9| 8| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 2|
| 7| 1| 0| 0| 7| 2| 0| 9| 9| 0| 0| 9| 1| 0| 0| 9| 0| 0| 1| 0| 0| 4| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | |
Abscess, Multifocal | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Seminiferous Tubule, | |
Vacuolization Cytoplasmic, | |
Diffuse | 3 |
Seminiferous Tubule, Degeneration, | |
Diffuse | 3 |
Seminiferous Tubule, Degeneration, | |
Focal | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia, Diffuse | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid, | |
Multifocal | 2 1 |
Inguinal, Hyperplasia, Diffuse, | |
Lymphoid | 3 |
Inguinal, Pigmentation, Diffuse | |
Renal, Hyperplasia, Lymphoid, | |
Multifocal | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Diffuse | 1 2 |
Hematopoietic Cell Proliferation, | |
Focal | 1 |
Hyperplasia, Diffuse, Lymphoid | 1 3 2 1 |
Hyperplasia, Diffuse, Re Cell | 3 |
Hyperplasia, Focal, Lymphoid | 1 1 |
Hyperplasia, Lymphoid, Multifocal | 1 1 1 1 1 |
Infiltration Cellular, Diffuse, | |
Plasma Cell | |
Inflammation, Acute, Diffuse | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Diffuse | 3 3 3 3 2 |
Hyperplasia, Diffuse, Lymphoid | 1 2 1 |
Hyperplasia, Focal, Lymphoid | 1 |
Hyperplasia, Lymphoid, Multifocal | 3 1 2 1 1 1 1|
Pigmentation, Diffuse | |
__________________________________________________________________________|
Thymus | M + + M M + + + + M + + M + + + + + + + + + + + +|
Atrophy, Diffuse | 2 3 |
Cyst, Single | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 8| 2| 3| 2| 9| 8| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 2|
| 7| 1| 0| 0| 7| 2| 0| 9| 9| 0| 0| 9| 1| 0| 0| 9| 0| 0| 1| 0| 0| 4| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Focal, Lymphoid | |
Mediastinum, Abscess, Focal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M + M M M M M M M M M + M M M M M M M M M|
Inflammation, Chronic, Multifocal | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + |
Acanthosis, Focal | 1 3 3 1 |
Acanthosis, Multifocal | 2 1 |
Cyst Epithelial Inclusion, Single | 2 |
Hyperkeratosis, Focal | 1 2 2 |
Hyperkeratosis, Multifocal | 1 |
Inflammation, Acute, Multifocal | |
Inflammation, Chronic, Diffuse | 2 |
Inflammation, Chronic, Focal | 4 |
Inflammation, Chronic, Multifocal | 1 |
Ulcer, Focal | 4 3 4 |
Artery, Subcutaneous Tissue, | |
Adventitia, Inflammation, | |
Chronic, Focal | |
Artery, Subcutaneous Tissue, | |
Adventitia, Inflammation, | |
Chronic, Multifocal | 2 |
Hair Follicle, Atrophy, Diffuse | 3 3 |
Hair Follicle, Inflammation, Chronic,| |
Multifocal | |
Prepuce, Cyst Epithelial Inclusion, | |
Focal | |
Subcutaneous Tissue, Head, Granuloma,| |
Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Thalamus, Mineralization, | |
Multifocal | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 |
Lateral Ventricle, Meninges, Abscess,| |
Multifocal | 4 |
Thalamus, Mineralization, Focal | |
Thalamus, Mineralization, Multifocal | 1 |
__________________________________________________________________________|
Peripheral Nerve | + + |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 8| 2| 3| 2| 9| 8| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 2|
| 7| 1| 0| 0| 7| 2| 0| 9| 9| 0| 0| 9| 1| 0| 0| 9| 0| 0| 1| 0| 0| 4| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Thrombosis, Diffuse | 4 |
Alveolar Epithelium, Hyperplasia | 2 2|
Peribronchial, Infiltration Cellular,| |
Multifocal, Lymphocyte | 1 1 1 1 1 2 2 1 1 1 1 2 1 2 2 1 3|
Peribronchiolar, Infiltration | |
Cellular, Multifocal, Lymphocyte | |
Perivascular, Infiltration Cellular, | |
Multifocal, Lymphocyte | 1 1 1 |
Pleura, Inflammation, Acute, Diffuse | |
Pleura, Inflammation, Acute, | |
Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 2 1 2 1 1 1 1 1 1 2 2 2 1 1 |
Glands, Hyperplasia | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic, Focal | |
Olfactory Epithelium, Atrophy | 1 2 2 2 2 2 2 |
Turbinate, Exudate | 1 2 2 2 1 2 |
Turbinate, Inflammation, Chronic, | |
Diffuse | 2 |
Turbinate, Inflammation, Chronic, | |
Focal | 2 1 |
Turbinate, Inflammation, Chronic, | |
Multifocal | 2 1 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Diffuse | 1 1 1 1 |
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic, Multifocal | 1 1 1 1 1 1|
Peritracheal Tissue, Inflammation, | |
Chronic, Multifocal | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium, Multifocal | |
Casts Protein, Diffuse | |
Cyst, Single | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 8| 2| 3| 2| 9| 8| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 2|
| 7| 1| 0| 0| 7| 2| 0| 9| 9| 0| 0| 9| 1| 0| 0| 9| 0| 0| 1| 0| 0| 4| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Hydronephrosis | 2 |
Inflammation, Acute, Multifocal | |
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic, Multifocal | 3 1 1 |
Bilateral, Inflammation, Acute, Focal| |
Bilateral, Inflammation, Chronic, | |
Focal | |
Bilateral, Inflammation, Chronic, | |
Multifocal | 1 1 1 2 2 2 2 1 2 1 2 2 2 1 1|
Bilateral, Artery, Inflammation, | |
Chronic, Multifocal | |
Bilateral, Renal Tubule, Casts | |
Protein, Multifocal | |
Bilateral, Renal Tubule, Concretion, | |
Multifocal | |
Bilateral, Renal Tubule, | |
Degeneration, Multifocal | |
Bilateral, Renal Tubule, | |
Regeneration, Multifocal | 1 |
Bilateral, Renal Tubule, | |
Vacuolization Cytoplasmic, | |
Multifocal | |
Interstitial Tissue, Inflammation, | |
Chronic, Diffuse | |
Renal Tubule, Casts Protein, Diffuse | |
Renal Tubule, Concretion, Multifocal | |
Renal Tubule, Degeneration, Focal | 1 |
Renal Tubule, Degeneration, | |
Multifocal | 1 |
Renal Tubule, Regeneration, | |
Multifocal | 1 |
__________________________________________________________________________|
Ureter | + |
Dilatation | 1 |
__________________________________________________________________________|
Urethra | |
Mucosa, Inflammation, Acute, Diffuse | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 1 1 |
Inflammation, Acute, Focal | |
Transitional Epithelium, Hyperplasia,| |
Diffuse | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 7| 8| 2| 3| 2| 9| 8| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 2|
| 7| 1| 0| 0| 7| 2| 0| 9| 9| 0| 0| 9| 1| 0| 0| 9| 0| 0| 1| 0| 0| 4| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Transitional Epithelium, | |
Vacuolization Cytoplasmic, | |
Diffuse | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 3| 7| 5| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 2| 2| 3| 3| 2| 0| 6| 3| 2| 3| 8| 3| 2| 9| 2| 7| 2| 3| 3| 2| |
| 9| 1| 1| 1| 1| 9| 9| 1| 1| 9| 0| 6| 0| 9| 1| 9| 7| 9| 2| 9| 7| 9| 0| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + M M + + M + + + + A + + + + + + M + M M + + + +| 38 |
Infiltration Cellular, Diffuse, | | |
Lymphocyte | 2 | 4 2.3|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 1 1.0|
Inflammation, Acute, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Inflammation, Acute, Focal | 1 1 1 1 1 1 1 1 1 1 1 1| 19 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 |
Cyst, Multiple | X | 1 |
Infarct, Focal | 4 4 | 2 4.0|
Necrosis, Coagulative, Diffuse | 4 | 1 4.0|
Bile Duct, Infiltration Cellular, | | |
Multifocal, Lymphocyte | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Inflammation, Acute, Diffuse | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess, Focal | 4 | 1 4.0|
Atrophy, Focal | 1 | 2 1.5|
Inflammation, Chronic, Focal | | 1 1.0|
Inflammation, Chronic, Multifocal | 1 1 | 2 1.0|
Necrosis, Focal | | 1 1.0|
Vacuolization Cytoplasmic, Multifocal| 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 5 1.6|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 1 2 1 2 2 1 2 | 17 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 3| 7| 5| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 2| 2| 3| 3| 2| 0| 6| 3| 2| 3| 8| 3| 2| 9| 2| 7| 2| 3| 3| 2| |
| 9| 1| 1| 1| 1| 9| 9| 1| 1| 9| 0| 6| 0| 9| 1| 9| 7| 9| 2| 9| 7| 9| 0| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Abscess, Focal | 2 | 4 1.8|
Abscess, Multifocal | | 1 1.0|
Acanthosis, Focal | | 2 3.0|
Acanthosis, Multifocal | 3 | 2 2.0|
Cyst Epithelial Inclusion, Focal | | 1 2.0|
Inflammation, Chronic, Focal | | 2 2.0|
Inflammation, Chronic, Multifocal | 2 | 1 2.0|
Serosa, Inflammation, Acute, Diffuse | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Artery, Adventitia, Inflammation, | | |
Chronic, Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Mesenteric Artery, Aorta, Adventitia,| | |
Inflammation, Chronic, | | |
Multifocal | 3 | 1 3.0|
Mesenteric Artery, Aorta, Media, | | |
Hypertrophy, Multifocal | 3 | 1 3.0|
Mesenteric Artery, Renal Artery, | | |
Adventitia, Inflammation, | | |
Chronic, Multifocal | 3 | 1 3.0|
Mesenteric Artery, Renal Artery, | | |
Media, Hypertrophy, Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic, | | |
Diffuse | 3 3 | 2 3.0|
Endocardium, Inflammation, Chronic, | | |
Focal | | 1 1.0|
Epicardium, Inflammation, Acute, | | |
Diffuse | 3 1 | 2 2.0|
Epicardium, Inflammation, Acute, | | |
Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 3| 7| 5| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 2| 2| 3| 3| 2| 0| 6| 3| 2| 3| 8| 3| 2| 9| 2| 7| 2| 3| 3| 2| |
| 9| 1| 1| 1| 1| 9| 9| 1| 1| 9| 0| 6| 0| 9| 1| 9| 7| 9| 2| 9| 7| 9| 0| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hypertrophy, Focal | 2 | 1 2.0|
Bilateral, Spindle Cell, Hyperplasia,| | |
Focal | | 1 1.0|
Bilateral, Spindle Cell, Hyperplasia,| | |
Multifocal | 1 1 1 2 1 2 1 1 1 1 | 25 1.3|
Spindle Cell, Hyperplasia, Focal | 1 1 1 1 1 2| 9 1.1|
Spindle Cell, Hyperplasia, Multifocal| 2 1 1 1 1 2 1 | 11 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vacuolization Cytoplasmic, Diffuse | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M M + + + M + M M + + + M + + + + M M + + M M| 27 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + M + + + + + + M M + + + + + + + M + + M| 40 |
Hypertrophy, Focal | 1 | 1 1.0|
Craniopharyngeal Duct, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 | 1 1.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 1.0|
Ultimobranchial Cyst | X | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular, Multifocal | 2 | 1 2.0|
Inflammation, Chronic, Focal | 2 2 1 | 4 1.5|
Inflammation, Chronic, Multifocal | 1 | 1 1.0|
Vacuolization Cytoplasmic, Diffuse | 2 | 1 2.0|
Bilateral, Vacuolization Cytoplasmic,| | |
Diffuse | | 1 3.0|
Bilateral, Vacuolization Cytoplasmic,| | |
Multifocal | 1 | 1 1.0|
Serosa, Inflammation, Acute, Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 3| 7| 5| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 2| 2| 3| 3| 2| 0| 6| 3| 2| 3| 8| 3| 2| 9| 2| 7| 2| 3| 3| 2| |
| 9| 1| 1| 1| 1| 9| 9| 1| 1| 9| 0| 6| 0| 9| 1| 9| 7| 9| 2| 9| 7| 9| 0| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + M | 10 |
Abscess, Focal | 4 4 4 | 4 4.0|
Abscess, Multifocal | | 1 4.0|
Dilatation | 2 | 1 2.0|
Inflammation, Chronic, Diffuse | 2 3 3 | 3 2.7|
Inflammation, Chronic, Multifocal | 2 | 1 2.0|
Bilateral, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess, Multifocal | 4 | 1 4.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 | 3 1.3|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 2 1.5|
Inflammation, Acute, Diffuse | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
Abscess, Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Seminiferous Tubule, | | |
Vacuolization Cytoplasmic, | | |
Diffuse | 2 | 2 2.5|
Seminiferous Tubule, Degeneration, | | |
Diffuse | | 1 3.0|
Seminiferous Tubule, Degeneration, | | |
Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myeloid Cell, Hyperplasia, Diffuse | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Hyperplasia, Lymphoid, | | |
Multifocal | | 2 1.5|
Inguinal, Hyperplasia, Diffuse, | | |
Lymphoid | | 1 3.0|
Inguinal, Pigmentation, Diffuse | 2 | 1 2.0|
Renal, Hyperplasia, Lymphoid, | | |
Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 3| 7| 5| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 2| 2| 3| 3| 2| 0| 6| 3| 2| 3| 8| 3| 2| 9| 2| 7| 2| 3| 3| 2| |
| 9| 1| 1| 1| 1| 9| 9| 1| 1| 9| 0| 6| 0| 9| 1| 9| 7| 9| 2| 9| 7| 9| 0| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Diffuse | 1 | 3 1.3|
Hematopoietic Cell Proliferation, | | |
Focal | | 1 1.0|
Hyperplasia, Diffuse, Lymphoid | 2 1 3 3 4 3 2 3 | 12 2.3|
Hyperplasia, Diffuse, Re Cell | 2 | 2 2.5|
Hyperplasia, Focal, Lymphoid | 1 | 3 1.0|
Hyperplasia, Lymphoid, Multifocal | 2 3 3 1 2 1| 11 1.5|
Infiltration Cellular, Diffuse, | | |
Plasma Cell | 2 | 1 2.0|
Inflammation, Acute, Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation, | | |
Diffuse | 2 2 3 3 | 9 2.7|
Hyperplasia, Diffuse, Lymphoid | 3 | 4 1.8|
Hyperplasia, Focal, Lymphoid | | 1 1.0|
Hyperplasia, Lymphoid, Multifocal | 1 1 1 2 2| 12 1.4|
Pigmentation, Diffuse | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +| 44 |
Atrophy, Diffuse | 3 3 3 4 | 6 3.0|
Cyst, Single | 2 | 1 2.0|
Hyperplasia, Focal, Lymphoid | 4 | 1 4.0|
Mediastinum, Abscess, Focal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M + M M M + + M M M M M M M M| 5 |
Inflammation, Chronic, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + | 26 |
Acanthosis, Focal | | 4 2.0|
Acanthosis, Multifocal | 2 | 3 1.7|
Cyst Epithelial Inclusion, Single | | 1 2.0|
Hyperkeratosis, Focal | | 3 1.7|
Hyperkeratosis, Multifocal | 2 | 2 1.5|
Inflammation, Acute, Multifocal | 3 | 1 3.0|
Inflammation, Chronic, Diffuse | 3 2 | 3 2.3|
Inflammation, Chronic, Focal | 4 | 2 4.0|
Inflammation, Chronic, Multifocal | 1 | 2 1.0|
Ulcer, Focal | 2 4 | 5 3.4|
Artery, Subcutaneous Tissue, | | |
Adventitia, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 3| 7| 5| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 2| 2| 3| 3| 2| 0| 6| 3| 2| 3| 8| 3| 2| 9| 2| 7| 2| 3| 3| 2| |
| 9| 1| 1| 1| 1| 9| 9| 1| 1| 9| 0| 6| 0| 9| 1| 9| 7| 9| 2| 9| 7| 9| 0| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Chronic, Focal | 3 | 1 3.0|
Artery, Subcutaneous Tissue, | | |
Adventitia, Inflammation, | | |
Chronic, Multifocal | | 1 2.0|
Hair Follicle, Atrophy, Diffuse | 3 | 3 3.0|
Hair Follicle, Inflammation, Chronic,| | |
Multifocal | 1 | 1 1.0|
Prepuce, Cyst Epithelial Inclusion, | | |
Focal | 3 | 1 3.0|
Subcutaneous Tissue, Head, Granuloma,| | |
Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Thalamus, Mineralization, | | |
Multifocal | 1 1 1 1 1 1 1 1| 23 1.0|
Lateral Ventricle, Meninges, Abscess,| | |
Multifocal | | 1 4.0|
Thalamus, Mineralization, Focal | 1 1 | 2 1.0|
Thalamus, Mineralization, Multifocal | 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | 2 | 1 2.0|
Thrombosis, Diffuse | | 1 4.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
Peribronchial, Infiltration Cellular,| | |
Multifocal, Lymphocyte | 1 1 2 1 1 2 2 1 1 1 2 1 | 29 1.4|
Peribronchiolar, Infiltration | | |
Cellular, Multifocal, Lymphocyte | 1 | 1 1.0|
Perivascular, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 1 | 4 1.0|
Pleura, Inflammation, Acute, Diffuse | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 3| 7| 5| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 2| 2| 3| 3| 2| 0| 6| 3| 2| 3| 8| 3| 2| 9| 2| 7| 2| 3| 3| 2| |
| 9| 1| 1| 1| 1| 9| 9| 1| 1| 9| 0| 6| 0| 9| 1| 9| 7| 9| 2| 9| 7| 9| 0| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Pleura, Inflammation, Acute, | | |
Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 3 1 1 1 1 1 1 1 1 1 | 25 1.3|
Glands, Hyperplasia | 1 1| 3 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic, Focal | 2 | 1 2.0|
Olfactory Epithelium, Atrophy | 2 2 2 2| 11 1.9|
Turbinate, Exudate | 3 2 2 | 9 1.9|
Turbinate, Inflammation, Chronic, | | |
Diffuse | | 1 2.0|
Turbinate, Inflammation, Chronic, | | |
Focal | 3 2 2 1| 6 1.8|
Turbinate, Inflammation, Chronic, | | |
Multifocal | 2 2 1 1 2 | 9 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Diffuse | 3 1 1 1 1 1 | 10 1.2|
Inflammation, Chronic, Focal | | 1 1.0|
Inflammation, Chronic, Multifocal | 1 1 1 1| 10 1.0|
Peritracheal Tissue, Inflammation, | | |
Chronic, Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium, Multifocal | 3 | 1 3.0|
Casts Protein, Diffuse | 4 | 1 4.0|
Cyst, Single | 3 | 1 3.0|
Hydronephrosis | | 1 2.0|
Inflammation, Acute, Multifocal | 3 | 1 3.0|
Inflammation, Chronic, Focal | 1 | 2 1.5|
Inflammation, Chronic, Multifocal | | 3 1.7|
Bilateral, Inflammation, Acute, Focal| 2 | 1 2.0|
Bilateral, Inflammation, Chronic, | | |
Focal | 1 | 1 1.0|
Bilateral, Inflammation, Chronic, | | |
Multifocal | 2 1 1 2 2 2 2 1 1 2 2 1 2 2| 29 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 4| 7| 7| 7| 2| 3| 7| 5| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 2| 3| 3| 3| 3| 2| 2| 3| 3| 2| 0| 6| 3| 2| 3| 8| 3| 2| 9| 2| 7| 2| 3| 3| 2| |
| 9| 1| 1| 1| 1| 9| 9| 1| 1| 9| 0| 6| 0| 9| 1| 9| 7| 9| 2| 9| 7| 9| 0| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Bilateral, Artery, Inflammation, | | |
Chronic, Multifocal | 3 | 1 3.0|
Bilateral, Renal Tubule, Casts | | |
Protein, Multifocal | 1 | 1 1.0|
Bilateral, Renal Tubule, Concretion, | | |
Multifocal | 2 | 1 2.0|
Bilateral, Renal Tubule, | | |
Degeneration, Multifocal | 3 | 1 3.0|
Bilateral, Renal Tubule, | | |
Regeneration, Multifocal | 1 | 2 1.0|
Bilateral, Renal Tubule, | | |
Vacuolization Cytoplasmic, | | |
Multifocal | 2 | 1 2.0|
Interstitial Tissue, Inflammation, | | |
Chronic, Diffuse | 4 | 1 4.0|
Renal Tubule, Casts Protein, Diffuse | 2 | 1 2.0|
Renal Tubule, Concretion, Multifocal | 2 | 1 2.0|
Renal Tubule, Degeneration, Focal | | 1 1.0|
Renal Tubule, Degeneration, | | |
Multifocal | 1 | 2 1.0|
Renal Tubule, Regeneration, | | |
Multifocal | 1 | 2 1.0|
__________________________________________________________________________|____________|
Ureter | | 1 |
Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Mucosa, Inflammation, Acute, Diffuse | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 | 1 3.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 3 | 3 1.7|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 2 1 1 1 2 1 | 13 1.3|
Inflammation, Acute, Focal | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia,| | |
Diffuse | 3 | 1 3.0|
Transitional Epithelium, | | |
Vacuolization Cytoplasmic, | | |
Diffuse | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 3| 2|
| 7| 1| 0| 0| 9| 7| 0| 1| 1| 9| 0| 9| 1| 9| 9| 2| 9| 0| 1| 0| 1| 1| 0| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
375 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation, Focal | 4 |
__________________________________________________________________________|
Gallbladder | A + + M + A + + M + + + M M + M + + + + M + + + +|
Infiltration Cellular, Diffuse, | |
Lymphocyte | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Acute, Diffuse | 1 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphoid Nodule, Hyperplasia, Focal, | |
Lymphoid | |
Lymphoid Nodule, Hyperplasia, | |
Lymphoid, Multifocal | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M + M + + + + + + + M + + + + + + + + +|
Inflammation, Acute, Focal | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Focal, | |
Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fatty Change, Multifocal | 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 1 |
Inflammation, Acute, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 |
Inflammation, Chronic, Focal | 1 1 1 3 |
Inflammation, Chronic, Multifocal | 1 2 |
Vacuolization Cytoplasmic, Multifocal| 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 1 2 1 1 2 1 2 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 2 1 2 2 2 1 1 1 1 2 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + M|
Abscess, Focal | 1 |
Abscess, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 3| 2|
| 7| 1| 0| 0| 9| 7| 0| 1| 1| 9| 0| 9| 1| 9| 9| 2| 9| 0| 1| 0| 1| 1| 0| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
375 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acanthosis, Focal | 2 3 |
Acanthosis, Multifocal | 2 |
Hyperkeratosis, Focal | |
Inflammation, Acute, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic, | |
Diffuse | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | |
Bilateral, Hypertrophy, Multifocal | 2 |
Bilateral, Spindle Cell, Hyperplasia,| |
Diffuse | |
Bilateral, Spindle Cell, Hyperplasia,| |
Multifocal | 1 1 1 1 2 1 2 2 3 2 2 1 2|
Spindle Cell, Hyperplasia, Focal | 1 1 1 2 1 |
Spindle Cell, Hyperplasia, Multifocal| 1 1 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | M + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M M M M + + M M + M + + M + + M M + + + M + M|
Cyst, Single | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic, Focal | 4 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Ultimobranchial Cyst | X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm, Focal | |
Inflammation, Chronic, Focal | 1 |
Spermatocele | X |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 3| 2|
| 7| 1| 0| 0| 9| 7| 0| 1| 1| 9| 0| 9| 1| 9| 9| 2| 9| 0| 1| 0| 1| 1| 0| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
375 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Bilateral, Inflammation, Chronic, | |
Multifocal | |
Bilateral, Vacuolization Cytoplasmic,| |
Multifocal | |
__________________________________________________________________________|
Preputial Gland | + |
Abscess, Multifocal | |
Dilatation | |
Inflammation, Chronic, Diffuse | |
Bilateral, Abscess, Multifocal | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 1 1 1|
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Seminiferous Tubule, | |
Degeneration, Diffuse | |
Bilateral, Seminiferous Tubule, | |
Vacuolization Cytoplasmic, | |
Diffuse | 2 |
Seminiferous Tubule, Degeneration, | |
Diffuse | 3 |
Seminiferous Tubule, Degeneration, | |
Focal | |
Seminiferous Tubule, Mineralization, | |
Focal | |
Seminiferous Tubule, Mineralization, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid, | |
Multifocal | 1 |
Inguinal, Pigmentation, Focal | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Diffuse | 1 2 2 2 |
Hyperplasia, Diffuse, Lymphoid | 3 |
Hyperplasia, Focal, Lymphoid | |
Hyperplasia, Lymphoid, Multifocal | 3 2 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Diffuse | 1 3 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 3| 2|
| 7| 1| 0| 0| 9| 7| 0| 1| 1| 9| 0| 9| 1| 9| 9| 2| 9| 0| 1| 0| 1| 1| 0| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
375 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Diffuse, Lymphoid | 3 |
Hyperplasia, Lymphoid, Multifocal | 2 1 1 1 2 1 1|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + M +|
Atrophy, Diffuse | 2 2 1 4 2 2 |
Mineralization, Multifocal | 1 |
Mediastinum, Hemorrhage, Focal | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M M + M M M + M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 1 |
Hyperkeratosis, Focal | 1 |
Inflammation, Chronic, Focal | 1 |
Subcutaneous Tissue, Edema, Diffuse | 3 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Thalamus, Mineralization, | |
Multifocal | 1 2 1 2 1 1 2 2 |
Thalamus, Mineralization, Focal | |
Thalamus, Mineralization, Multifocal | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 1 |
Hemorrhage, Multifocal | |
Alveolar Epithelium, Hypertrophy, | |
Focal | 1 2 |
Peribronchial, Infiltration Cellular,| |
Multifocal, Lymphocyte | 1 1 2 1 2 1 2 2 2 2 1 1 1 1 1 2 1 1 1|
Perivascular, Infiltration Cellular, | |
Multifocal, Lymphocyte | 1 1 1 |
Pleura, Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 2 2 1 1 2 2 1 2 1 |
Glands, Hyperplasia | 2 1 2 1 3 2 2 2 2 1 2 2 2 2 2 1 1 2 1 2|
Olfactory Epithelium, Atrophy | 3 2 2 1 3 2 3 2 2 2 2 3 3 3 2 2 2 3 2 2|
Turbinate, Exudate | 2 2 3 2 |
Turbinate, Hemorrhage, Focal | 2 |
Turbinate, Inflammation, Acute, Focal| |
Turbinate, Inflammation, Acute, | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 2| 0| 3| 3| 3| 2| 3| 2| 3| 2| 2| 5| 2| 3| 3| 3| 3| 3| 3| 3| 2|
| 7| 1| 0| 0| 9| 7| 0| 1| 1| 9| 0| 9| 1| 9| 9| 2| 9| 0| 1| 0| 1| 1| 0| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
375 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Multifocal | 1 1 1 |
Turbinate, Inflammation, Chronic, | |
Diffuse | 1 2 |
Turbinate, Inflammation, Chronic, | |
Focal | 1 2 |
Turbinate, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Diffuse | 2 2 1 |
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic, Multifocal | 1 2 |
Peritracheal Tissue, Hemorrhage, | |
Diffuse | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Single | 1 |
Inflammation, Chronic, Focal | 1 1 1 |
Inflammation, Chronic, Multifocal | 1 3 |
Bilateral, Inflammation, Chronic, | |
Multifocal | 1 2 1 2 2 2 1 1 1 2 |
Bilateral, Renal Tubule, Concretion, | |
Multifocal | |
Bilateral, Renal Tubule, | |
Degeneration, Multifocal | 2 |
Bilateral, Renal Tubule, | |
Regeneration, Multifocal | 1 1 |
Renal Tubule, Degeneration, Focal | 1 2 |
Renal Tubule, Regeneration, Focal | 2 1 |
Renal Tubule, Regeneration, | |
Multifocal | 1 1 1 |
Renal Tubule, Vacuolization | |
Cytoplasmic, Multifocal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 2| 2| 6| 3| 2| 3| 2| 3| 6| 3| 3| 2| 3| 2| |
| 0| 0| 1| 0| 0| 5| 9| 1| 0| 4| 9| 9| 9| 3| 1| 9| 0| 9| 1| 9| 0| 1| 9| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
375 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Perforation, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + M + M + + + + + + + + M + A + M + M +| 36 |
Infiltration Cellular, Diffuse, | | |
Lymphocyte | 2 | 2 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 2 | 3 1.3|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 1 1.0|
Inflammation, Acute, Diffuse | 1 2| 4 1.5|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + M M + + + + + + + + + + + + + A + + + + +| 46 |
Lymphoid Nodule, Hyperplasia, Focal, | | |
Lymphoid | 2 | 1 2.0|
Lymphoid Nodule, Hyperplasia, | | |
Lymphoid, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + M + +| 45 |
Inflammation, Acute, Focal | 1 2 1 1 1 1 1 1| 15 1.1|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Peyer's Patch, Hyperplasia, Focal, | | |
Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fatty Change, Multifocal | | 1 1.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 3 1.0|
Inflammation, Acute, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 1 | 3 1.0|
Inflammation, Chronic, Focal | 1 1 1| 7 1.3|
Inflammation, Chronic, Multifocal | | 2 1.5|
Vacuolization Cytoplasmic, Multifocal| | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 1 | 10 1.3|
Infiltration Cellular, Multifocal, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 2| 2| 6| 3| 2| 3| 2| 3| 6| 3| 3| 2| 3| 2| |
| 0| 0| 1| 0| 0| 5| 9| 1| 0| 4| 9| 9| 9| 3| 1| 9| 0| 9| 1| 9| 0| 1| 9| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
375 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Lymphocyte | 1 2 1 2 1 2 2 2 2 2 2 2 | 25 1.6|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Abscess, Focal | 2 2 | 3 1.7|
Abscess, Multifocal | 2 2| 3 2.0|
Acanthosis, Focal | 2 | 3 2.3|
Acanthosis, Multifocal | 2 | 2 2.0|
Hyperkeratosis, Focal | 1 2 | 2 1.5|
Inflammation, Acute, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Inflammation, Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic, | | |
Diffuse | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy, Focal | 1 2 2 | 3 1.7|
Bilateral, Hypertrophy, Multifocal | | 1 2.0|
Bilateral, Spindle Cell, Hyperplasia,| | |
Diffuse | 3 | 1 3.0|
Bilateral, Spindle Cell, Hyperplasia,| | |
Multifocal | 1 1 2 3 2 2 2 2 2 1 2 2 2 1 2 1 2 | 30 1.7|
Spindle Cell, Hyperplasia, Focal | 1 1 1| 8 1.1|
Spindle Cell, Hyperplasia, Multifocal| 2 2 | 6 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M M + M M + + M + + + + M + + M M M + + + +| 27 |
Cyst, Single | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic, Focal | | 1 4.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 2| 2| 6| 3| 2| 3| 2| 3| 6| 3| 3| 2| 3| 2| |
| 0| 0| 1| 0| 0| 5| 9| 1| 0| 4| 9| 9| 9| 3| 1| 9| 0| 9| 1| 9| 0| 1| 9| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
375 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Ultimobranchial Cyst | X X X X X | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm, Focal | 2 | 1 2.0|
Inflammation, Chronic, Focal | 2 | 2 1.5|
Spermatocele | | 1 |
Bilateral, Inflammation, Chronic, | | |
Multifocal | 1 | 1 1.0|
Bilateral, Vacuolization Cytoplasmic,| | |
Multifocal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + | 4 |
Abscess, Multifocal | 4 | 1 4.0|
Dilatation | 2 | 1 2.0|
Inflammation, Chronic, Diffuse | 2 | 1 2.0|
Bilateral, Abscess, Multifocal | 4 | 2 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 | 4 1.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Seminiferous Tubule, | | |
Degeneration, Diffuse | 3 | 1 3.0|
Bilateral, Seminiferous Tubule, | | |
Vacuolization Cytoplasmic, | | |
Diffuse | 2 2 | 3 2.0|
Seminiferous Tubule, Degeneration, | | |
Diffuse | | 1 3.0|
Seminiferous Tubule, Degeneration, | | |
Focal | 2 | 1 2.0|
Seminiferous Tubule, Mineralization, | | |
Focal | 1 | 1 1.0|
Seminiferous Tubule, Mineralization, | | |
Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 2| 2| 6| 3| 2| 3| 2| 3| 6| 3| 3| 2| 3| 2| |
| 0| 0| 1| 0| 0| 5| 9| 1| 0| 4| 9| 9| 9| 3| 1| 9| 0| 9| 1| 9| 0| 1| 9| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
375 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Lymphoid, | | |
Multifocal | | 1 1.0|
Inguinal, Pigmentation, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation, | | |
Diffuse | 1 2 2 | 7 1.7|
Hyperplasia, Diffuse, Lymphoid | | 1 3.0|
Hyperplasia, Focal, Lymphoid | 1 | 1 1.0|
Hyperplasia, Lymphoid, Multifocal | 1 1 1 | 7 1.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation, | | |
Diffuse | 1 | 3 1.7|
Hyperplasia, Diffuse, Lymphoid | 3 | 2 3.0|
Hyperplasia, Lymphoid, Multifocal | 1 2 1 1 | 11 1.3|
__________________________________________________________________________|____________|
Thymus | M + + + + M + + + + M + + + M + M + + + + + + + M| 42 |
Atrophy, Diffuse | 4 4 | 8 2.6|
Mineralization, Multifocal | | 1 1.0|
Mediastinum, Hemorrhage, Focal | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M + M M M M M M M M M M M| 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + +| 45 |
Acanthosis, Focal | | 1 1.0|
Hyperkeratosis, Focal | | 1 1.0|
Inflammation, Chronic, Focal | 2 | 2 1.5|
Subcutaneous Tissue, Edema, Diffuse | | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Thalamus, Mineralization, | | |
Multifocal | 1 2 1 1 1 1 1 1 2 2 2 1| 20 1.4|
Thalamus, Mineralization, Focal | 1 | 1 1.0|
Thalamus, Mineralization, Multifocal | 1 1 1 1 | 9 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 2| 2| 6| 3| 2| 3| 2| 3| 6| 3| 3| 2| 3| 2| |
| 0| 0| 1| 0| 0| 5| 9| 1| 0| 4| 9| 9| 9| 3| 1| 9| 0| 9| 1| 9| 0| 1| 9| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
375 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | 1 | 2 1.0|
Hemorrhage, Multifocal | 1 2 | 2 1.5|
Alveolar Epithelium, Hypertrophy, | | |
Focal | 2 1 | 4 1.5|
Peribronchial, Infiltration Cellular,| | |
Multifocal, Lymphocyte | 1 1 1 2 1 1 1 2 1 2 2 2 1| 32 1.4|
Perivascular, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 1 2 | 5 1.2|
Pleura, Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 1 1 1 2 2 1 1 2 2 2 1 2| 23 1.5|
Glands, Hyperplasia | 2 2 1 1 1 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2 1 1| 42 1.7|
Olfactory Epithelium, Atrophy | 3 3 1 2 2 3 2 2 2 3 1 3 1 2 2 3 3 2 3 2 2 1| 42 2.2|
Turbinate, Exudate | 2 2 3 2 2 2| 10 2.2|
Turbinate, Hemorrhage, Focal | | 1 2.0|
Turbinate, Inflammation, Acute, Focal| 1 | 1 1.0|
Turbinate, Inflammation, Acute, | | |
Multifocal | | 3 1.0|
Turbinate, Inflammation, Chronic, | | |
Diffuse | 2 2 2 3 | 6 2.0|
Turbinate, Inflammation, Chronic, | | |
Focal | | 2 1.5|
Turbinate, Inflammation, Chronic, | | |
Multifocal | 1 2 2| 3 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Diffuse | 2 1 1 2 1 | 8 1.5|
Inflammation, Chronic, Focal | 1 | 2 1.0|
Inflammation, Chronic, Multifocal | 1 1 1 | 5 1.2|
Peritracheal Tissue, Hemorrhage, | | |
Diffuse | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 2| 2| 3| 3| 1| 2| 2| 2| 6| 3| 2| 3| 2| 3| 6| 3| 3| 2| 3| 2| |
| 0| 0| 1| 0| 0| 5| 9| 1| 0| 4| 9| 9| 9| 3| 1| 9| 0| 9| 1| 9| 0| 1| 9| 1| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
375 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cyst, Single | X X X | 4 1.0|
Inflammation, Chronic, Focal | 1 1 | 5 1.0|
Inflammation, Chronic, Multifocal | 2 | 3 2.0|
Bilateral, Inflammation, Chronic, | | |
Multifocal | 2 3 1 2 1 1 2 1 1 2 1 2 2 2 2| 25 1.6|
Bilateral, Renal Tubule, Concretion, | | |
Multifocal | 1 1 | 2 1.0|
Bilateral, Renal Tubule, | | |
Degeneration, Multifocal | 2 | 2 2.0|
Bilateral, Renal Tubule, | | |
Regeneration, Multifocal | | 2 1.0|
Renal Tubule, Degeneration, Focal | 3 2 | 4 2.0|
Renal Tubule, Regeneration, Focal | | 2 1.5|
Renal Tubule, Regeneration, | | |
Multifocal | 2 | 4 1.3|
Renal Tubule, Vacuolization | | |
Cytoplasmic, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + M + + M + + + A + + + + +| 47 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 1 2 | 3 1.3|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 | 6 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 3| 4| 5| 7| 7| 4| 7| 7| 7| 7| 0| 1| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 9| 2| 2| 9| 2| 3| 3| 1| 0| 7| 3| 2| 3| 3| 3| 2| 2| 3|
| 1| 0| 1| 0| 0| 2| 1| 2| 9| 9| 8| 9| 0| 1| 8| 3| 5| 0| 9| 1| 1| 0| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
750 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Hemorrhage, | |
Focal | |
Periesophageal Tissue, Inflammation, | |
Acute, Diffuse | 3 |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + A A + + + + + + + +|
Infiltration Cellular, Diffuse, | |
Lymphocyte | |
Inflammation, Acute, Focal | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + + M + + + + + + +|
Inflammation, Acute, Focal | 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + M A + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid,| |
Multifocal | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +|
Peyer's Patch, Hyperplasia, Focal, | |
Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + A + + + + + + + +|
Fatty Change, Multifocal | |
Infarct, Focal | 4|
Necrosis, Coagulative, Multifocal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +|
Atrophy, Focal | 1 |
Artery, Media, Mineralization, | |
Multifocal | |
Duct, Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 1 1 1 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 1 2 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + M + + + + + + + + A + + + + + + + +|
Acanthosis, Focal | 2 |
Acanthosis, Multifocal | 2 3 3 3 |
Cyst Epithelial Inclusion, Focal | 1|
Inflammation, Acute, Focal | 1|
Inflammation, Acute, Multifocal | 2 |
Inflammation, Chronic, Focal | 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 3| 4| 5| 7| 7| 4| 7| 7| 7| 7| 0| 1| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 9| 2| 2| 9| 2| 3| 3| 1| 0| 7| 3| 2| 3| 3| 3| 2| 2| 3|
| 1| 0| 1| 0| 0| 2| 1| 2| 9| 9| 8| 9| 0| 1| 8| 3| 5| 0| 9| 1| 1| 0| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
750 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic, Multifocal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +|
Inflammation, Acute, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endocardium, Inflammation, Acute, | |
Focal | 2 |
Epicardium, Inflammation, Acute, | |
Diffuse | 1 |
Epicardium, Inflammation, Acute, | |
Focal | 1 |
Ventricle Left, Myocardium, | |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | 1 2 |
Bilateral, Spindle Cell, Hyperplasia,| |
Multifocal | 1 1 1 1 1 1 2 1 2 2|
Spindle Cell, Hyperplasia, Diffuse | 2 |
Spindle Cell, Hyperplasia, Focal | 1 1 1 1 |
Spindle Cell, Hyperplasia, Multifocal| 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M M + + M M + + M M + M M M M M + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X X X X X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular, Multifocal | 1 |
Inflammation, Chronic, Focal | 1 |
Vacuolization Cytoplasmic, Diffuse | 2 |
Vacuolization Cytoplasmic, Focal | |
Bilateral, Atypia Cellular, | |
Multifocal | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 3| 4| 5| 7| 7| 4| 7| 7| 7| 7| 0| 1| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 9| 2| 2| 9| 2| 3| 3| 1| 0| 7| 3| 2| 3| 3| 3| 2| 2| 3|
| 1| 0| 1| 0| 0| 2| 1| 2| 9| 9| 8| 9| 0| 1| 8| 3| 5| 0| 9| 1| 1| 0| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
750 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Bilateral, Vacuolization Cytoplasmic,| |
Diffuse | |
__________________________________________________________________________|
Preputial Gland | + + |
Abscess, Focal | |
Dilatation | 2 |
Inflammation, Chronic, Diffuse | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 1 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Seminiferous Tubule, | |
Vacuolization Cytoplasmic, | |
Diffuse | |
Seminiferous Tubule, Degeneration, | |
Diffuse | 4 |
Seminiferous Tubule, Degeneration, | |
Focal | 2 |
Seminiferous Tubule, Vacuolization | |
Cytoplasmic, Diffuse | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + M + + + + + + + + + +|
Erythroid Cell, Hyperplasia, Diffuse | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + A + + + + + + + +|
Inguinal, Pigmentation, Multifocal | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia, Diffuse, Lymphoid | 2 |
Hyperplasia, Focal, Lymphoid | 1 |
Hyperplasia, Lymphoid, Multifocal | 1 2 2 |
Thrombosis | X |
Mediastinal, Hyperplasia, Lymphoid, | |
Multifocal | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Diffuse | 3 2 |
Hyperplasia, Diffuse, Lymphoid | 1|
Hyperplasia, Lymphoid, Multifocal | 1 1 3 1 1 1 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + M + + + + + + + +|
Atrophy, Diffuse | 3 2 3 2 |
Hyperplasia, Diffuse, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 3| 4| 5| 7| 7| 4| 7| 7| 7| 7| 0| 1| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 9| 2| 2| 9| 2| 3| 3| 1| 0| 7| 3| 2| 3| 3| 3| 2| 2| 3|
| 1| 0| 1| 0| 0| 2| 1| 2| 9| 9| 8| 9| 0| 1| 8| 3| 5| 0| 9| 1| 1| 0| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
750 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M I M M M + M M M M + M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + |
Acanthosis, Multifocal | 1 1 |
Hyperkeratosis, Multifocal | |
Inflammation, Chronic, Diffuse | |
Inflammation, Chronic, Focal | |
Back, Ulcer, Focal | |
Hair Follicle, Atrophy, Diffuse | 3 |
Hair Follicle, Atrophy, Focal | |
Neck, Edema, Diffuse | 2 |
Prepuce, Acanthosis, Diffuse | |
Prepuce, Inflammation, Chronic, | |
Diffuse | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Thalamus, Mineralization, | |
Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Cerebellum, Hemorrhage, Multifocal | |
Olfactory Lobe, Mineralization, Focal| 2 |
Thalamus, Mineralization, Multifocal | 1 1 1 1 |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + |
Hemorrhage | 3 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Diffuse | 3 |
Foreign Body | 2 |
Hemorrhage, Multifocal | 1 3 |
Alveolar Epithelium, Hyperplasia | |
Alveolar Epithelium, Hypertrophy, | |
Focal | 2 |
Alveolus, Foreign Body, Multifocal | |
Peribronchial, Infiltration Cellular,| |
Multifocal, Lymphocyte | 1 1 1 1 1 1 1 1 2|
Perivascular, Infiltration Cellular, | |
Multifocal, Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + M + + + + + + + + + +|
Foreign Body | 1 2 2 2 2 2 2 2 1 1 3 1 1 1|
Glands, Hyperplasia | 2 2 2 2 2 2 3 3 3 2 3 3 3 3 2 3 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 3| 4| 5| 7| 7| 4| 7| 7| 7| 7| 0| 1| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 9| 2| 2| 9| 2| 3| 3| 1| 0| 7| 3| 2| 3| 3| 3| 2| 2| 3|
| 1| 0| 1| 0| 0| 2| 1| 2| 9| 9| 8| 9| 0| 1| 8| 3| 5| 0| 9| 1| 1| 0| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
750 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nasolacrimal Duct, Inflammation, | |
Chronic, Diffuse | 3 |
Olfactory Epithelium, Atrophy | 3 2 3 3 3 3 4 3 4 3 3 3 3 4 3 3 3 4 4 3 3|
Turbinate, Congestion, Diffuse | 3 |
Turbinate, Exudate | 2 2 2 1|
Turbinate, Foreign Body | |
Turbinate, Hemorrhage, Diffuse | 3 3 3 |
Turbinate, Inflammation, Acute, | |
Diffuse | 1 |
Turbinate, Inflammation, Acute, Focal| 1 |
Turbinate, Inflammation, Acute, | |
Multifocal | 1 2 1 1 1 1 2 1 1 1|
Turbinate, Inflammation, Chronic, | |
Diffuse | |
Turbinate, Inflammation, Chronic, | |
Multifocal | 2 3 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Multifocal | 1 1 1 1 1 1 1 1|
Peritracheal Tissue, Foreign Body, | |
Multifocal | 2 |
Peritracheal Tissue, Hemorrhage, | |
Diffuse | 3 |
Peritracheal Tissue, Hemorrhage, | |
Multifocal | 3 |
Peritracheal Tissue, Inflammation, | |
Acute, Multifocal | 3 |
Peritracheal Tissue, Inflammation, | |
Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +|
Cyst, Multiple | 1 |
Cyst, Single | X |
Inflammation, Chronic, Focal | 1 1 1 1 1 |
Inflammation, Chronic, Multifocal | 1 |
Bilateral, Cyst, Multiple | |
Bilateral, Inflammation, Chronic, | |
Multifocal | 1 1 1 1 1 1 1 1 1|
Bilateral, Renal Tubule, | |
Degeneration, Multifocal | 3 |
Bilateral, Renal Tubule, | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 3| 4| 5| 7| 7| 4| 7| 7| 7| 7| 0| 1| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 9| 2| 2| 9| 2| 3| 3| 1| 0| 7| 3| 2| 3| 3| 3| 2| 2| 3|
| 1| 0| 1| 0| 0| 2| 1| 2| 9| 9| 8| 9| 0| 1| 8| 3| 5| 0| 9| 1| 1| 0| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
750 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Regeneration, Multifocal | 1 1 |
Renal Tubule, Degeneration, Focal | 1 |
Renal Tubule, Degeneration, | |
Multifocal | 1|
Renal Tubule, Regeneration, Focal | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +|
Dilatation | |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 0| 3| 0| 2| 3| 0| 2| 3| 3| 3| 9| 2| 3| 3| 2| 0| 2| 3| 2| 3| |
| 3| 1| 0| 0| 1| 4| 1| 7| 9| 0| 1| 9| 0| 1| 1| 5| 9| 0| 1| 9| 2| 9| 1| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
750 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Periesophageal Tissue, Hemorrhage, | | |
Focal | 4 | 1 4.0|
Periesophageal Tissue, Inflammation, | | |
Acute, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + M M + A + + + + M + + A + + + + + + + + +| 43 |
Infiltration Cellular, Diffuse, | | |
Lymphocyte | 2 | 1 2.0|
Inflammation, Acute, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + + + + + M + + + + M + + + + + M +| 44 |
Inflammation, Acute, Focal | 1 1 1 1 1 1 1 1 | 18 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + A + + + +| 46 |
Peyer's Patch, Hyperplasia, Lymphoid,| | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Peyer's Patch, Hyperplasia, Focal, | | |
Lymphoid | 3 | 2 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fatty Change, Multifocal | 3 | 1 3.0|
Infarct, Focal | | 1 4.0|
Necrosis, Coagulative, Multifocal | 3 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Atrophy, Focal | 1| 2 1.0|
Artery, Media, Mineralization, | | |
Multifocal | 3 | 1 3.0|
Duct, Inflammation, Chronic, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 1 | 7 1.3|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 1 1 | 11 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
Acanthosis, Focal | 2 3 2 1 | 5 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 0| 3| 0| 2| 3| 0| 2| 3| 3| 3| 9| 2| 3| 3| 2| 0| 2| 3| 2| 3| |
| 3| 1| 0| 0| 1| 4| 1| 7| 9| 0| 1| 9| 0| 1| 1| 5| 9| 0| 1| 9| 2| 9| 1| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
750 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acanthosis, Multifocal | 3 1 | 6 2.5|
Cyst Epithelial Inclusion, Focal | | 1 1.0|
Inflammation, Acute, Focal | | 1 1.0|
Inflammation, Acute, Multifocal | | 1 2.0|
Inflammation, Chronic, Focal | 1 1 2 | 6 1.5|
Inflammation, Chronic, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Inflammation, Acute, Focal | 2 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endocardium, Inflammation, Acute, | | |
Focal | | 1 2.0|
Epicardium, Inflammation, Acute, | | |
Diffuse | | 1 1.0|
Epicardium, Inflammation, Acute, | | |
Focal | 2 | 2 1.5|
Ventricle Left, Myocardium, | | |
Hemorrhage, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy, Focal | | 2 1.5|
Bilateral, Spindle Cell, Hyperplasia,| | |
Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 23 1.1|
Spindle Cell, Hyperplasia, Diffuse | | 1 2.0|
Spindle Cell, Hyperplasia, Focal | 2| 5 1.2|
Spindle Cell, Hyperplasia, Multifocal| 2 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M M M + M + M M + M + + + M + + + + M + + +| 26 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + M +| 48 |
Craniopharyngeal Duct, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ultimobranchial Cyst | X | 7 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 0| 3| 0| 2| 3| 0| 2| 3| 3| 3| 9| 2| 3| 3| 2| 0| 2| 3| 2| 3| |
| 3| 1| 0| 0| 1| 4| 1| 7| 9| 0| 1| 9| 0| 1| 1| 5| 9| 0| 1| 9| 2| 9| 1| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
750 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular, Multifocal | | 1 1.0|
Inflammation, Chronic, Focal | 2 | 2 1.5|
Vacuolization Cytoplasmic, Diffuse | 1 | 2 1.5|
Vacuolization Cytoplasmic, Focal | 1 | 1 1.0|
Bilateral, Atypia Cellular, | | |
Multifocal | 2 | 4 1.3|
Bilateral, Vacuolization Cytoplasmic,| | |
Diffuse | 1 | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 3 |
Abscess, Focal | 4 | 1 4.0|
Dilatation | | 1 2.0|
Inflammation, Chronic, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 2 1.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Seminiferous Tubule, | | |
Vacuolization Cytoplasmic, | | |
Diffuse | 2 | 1 2.0|
Seminiferous Tubule, Degeneration, | | |
Diffuse | | 1 4.0|
Seminiferous Tubule, Degeneration, | | |
Focal | | 1 2.0|
Seminiferous Tubule, Vacuolization | | |
Cytoplasmic, Diffuse | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erythroid Cell, Hyperplasia, Diffuse | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inguinal, Pigmentation, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Hyperplasia, Diffuse, Lymphoid | | 1 2.0|
Hyperplasia, Focal, Lymphoid | | 1 1.0|
Hyperplasia, Lymphoid, Multifocal | 2 2 1 1 2 1 1 | 10 1.5|
Thrombosis | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 0| 3| 0| 2| 3| 0| 2| 3| 3| 3| 9| 2| 3| 3| 2| 0| 2| 3| 2| 3| |
| 3| 1| 0| 0| 1| 4| 1| 7| 9| 0| 1| 9| 0| 1| 1| 5| 9| 0| 1| 9| 2| 9| 1| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
750 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hyperplasia, Lymphoid, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Hematopoietic Cell Proliferation, | | |
Diffuse | 2 2 2 3 | 6 2.3|
Hyperplasia, Diffuse, Lymphoid | 3 | 2 2.0|
Hyperplasia, Lymphoid, Multifocal | 1 2 1 1 | 10 1.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + M + + M + + M + + + + + +| 44 |
Atrophy, Diffuse | 4 | 5 2.8|
Hyperplasia, Diffuse, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M M + M M M M + M M M M M M M M M M M M M M| 6 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 15 |
Acanthosis, Multifocal | 1 2 1 | 5 1.2|
Hyperkeratosis, Multifocal | 1 | 1 1.0|
Inflammation, Chronic, Diffuse | 2 | 1 2.0|
Inflammation, Chronic, Focal | 1 | 1 1.0|
Back, Ulcer, Focal | 4 | 1 4.0|
Hair Follicle, Atrophy, Diffuse | | 1 3.0|
Hair Follicle, Atrophy, Focal | 1 1 2 | 3 1.3|
Neck, Edema, Diffuse | | 1 2.0|
Prepuce, Acanthosis, Diffuse | 1 | 1 1.0|
Prepuce, Inflammation, Chronic, | | |
Diffuse | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Thalamus, Mineralization, | | |
Multifocal | 1 1 1 1 1 1 1 1 1| 22 1.0|
Cerebellum, Hemorrhage, Multifocal | 3 | 1 3.0|
Olfactory Lobe, Mineralization, Focal| | 1 2.0|
Thalamus, Mineralization, Multifocal | 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 0| 3| 0| 2| 3| 0| 2| 3| 3| 3| 9| 2| 3| 3| 2| 0| 2| 3| 2| 3| |
| 3| 1| 0| 0| 1| 4| 1| 7| 9| 0| 1| 9| 0| 1| 1| 5| 9| 0| 1| 9| 2| 9| 1| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
750 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Larynx | | 1 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion, Diffuse | | 1 3.0|
Foreign Body | | 1 2.0|
Hemorrhage, Multifocal | 4 | 3 2.7|
Alveolar Epithelium, Hyperplasia | 4 | 1 4.0|
Alveolar Epithelium, Hypertrophy, | | |
Focal | | 1 2.0|
Alveolus, Foreign Body, Multifocal | 3 | 1 3.0|
Peribronchial, Infiltration Cellular,| | |
Multifocal, Lymphocyte | 2 1 1 1 1 1 1 1 1 1 1 1 | 21 1.1|
Perivascular, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 3 1 1 1 2 1 1 1 1 1 1 1 | 26 1.5|
Glands, Hyperplasia | 3 3 3 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3| 44 2.8|
Nasolacrimal Duct, Inflammation, | | |
Chronic, Diffuse | | 1 3.0|
Olfactory Epithelium, Atrophy | 4 3 4 4 4 4 4 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 44 3.3|
Turbinate, Congestion, Diffuse | | 1 3.0|
Turbinate, Exudate | 2 2 1 3 | 8 1.9|
Turbinate, Foreign Body | 1 | 1 1.0|
Turbinate, Hemorrhage, Diffuse | 2 3 3 | 6 2.8|
Turbinate, Inflammation, Acute, | | |
Diffuse | | 1 1.0|
Turbinate, Inflammation, Acute, Focal| 1| 2 1.0|
Turbinate, Inflammation, Acute, | | |
Multifocal | 1 1 1 1 1 1 2 1 1 1 1 2 2 1 1 1 1| 27 1.2|
Turbinate, Inflammation, Chronic, | | |
Diffuse | 2 | 1 2.0|
Turbinate, Inflammation, Chronic, | | |
Multifocal | 2 1 | 6 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Inflammation, Chronic, Multifocal | 1 1 1 | 11 1.0|
Peritracheal Tissue, Foreign Body, | | |
Multifocal | | 1 2.0|
Peritracheal Tissue, Hemorrhage, | | |
Diffuse | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05032-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC CARVONE Date: 04/17/97
Route: GAVAGE Time: 13:44:01
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 3| 3| 3| 0| 3| 0| 2| 3| 0| 2| 3| 3| 3| 9| 2| 3| 3| 2| 0| 2| 3| 2| 3| |
| 3| 1| 0| 0| 1| 4| 1| 7| 9| 0| 1| 9| 0| 1| 1| 5| 9| 0| 1| 9| 2| 9| 1| 9| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
750 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Peritracheal Tissue, Hemorrhage, | | |
Multifocal | | 1 3.0|
Peritracheal Tissue, Inflammation, | | |
Acute, Multifocal | | 1 3.0|
Peritracheal Tissue, Inflammation, | | |
Chronic, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst, Multiple | | 1 1.0|
Cyst, Single | | 1 |
Inflammation, Chronic, Focal | 1 1 | 7 1.0|
Inflammation, Chronic, Multifocal | 1 1 | 3 1.0|
Bilateral, Cyst, Multiple | 2 | 1 2.0|
Bilateral, Inflammation, Chronic, | | |
Multifocal | 1 1 1 2 1 1 1 1 1 1| 19 1.1|
Bilateral, Renal Tubule, | | |
Degeneration, Multifocal | | 1 3.0|
Bilateral, Renal Tubule, | | |
Regeneration, Multifocal | | 2 1.0|
Renal Tubule, Degeneration, Focal | | 1 1.0|
Renal Tubule, Degeneration, | | |
Multifocal | | 1 1.0|
Renal Tubule, Regeneration, Focal | 1 | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
Dilatation | 3 | 1 3.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 1 1 | 3 1.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 1 | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
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