TR 381 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/04/94
EXP: 05032 CARVONE TIME: 19:33:46
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 55867A
CONT: CAS: 99490
PATHOLOGIST: DR. A. BOOTHE S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/04/94
EXP: 05032 CARVONE TIME: 19:33:46
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 55867A
CONT: CAS: 99490
PATHOLOGIST: DR. A. BOOTHE S. EUSTIS
CARVONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 200 289 337 466 504 577 592 622 637 670 |
| 680 687 699 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 375 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 207 329 407 525 552 663 669 714 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 750 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 4 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 130 175 332 401 461 592 602 695 707 718 |
| CENSORED DEATHS |
| 3 3 4 498 |
| |
==================================================================================
CARVONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 98.0 94.0 94.0 92.0 90.0 86.0 82.0 74.0 |
|CONTROL | |
| | |
|375 | 100.0 100.0 98.0 96.0 94.0 94.0 92.0 90.0 88.0 84.0 |
|MG/KG | |
| | |
|750 | 100.0 95.7 95.7 93.6 91.5 89.4 89.4 85.0 85.0 78.5 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 375 750 |
| CONTROL MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 74.0% 84.0% 78.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.675N P=0.329N P=0.784N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 535.4 508.3 481.3 |
|NATURAL DEATHS (C) | (46.0) (63.7) (68.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 678.7 693.7 631.3 |
|(STANDARD ERROR) | (16.8) (15.0) (29.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
CARVONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 36 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 407 417 420 436 465 483 491 522 533 533 |
| 565 576 579 591 598 609 610 627 638 643 |
| 645 653 658 670 676 681 692 693 693 695 |
| 705 707 708 708 709 709 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 375 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 2 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 312 435 489 491 550 565 580 582 597 608 |
| 612 625 626 642 645 659 673 693 707 |
| CENSORED DEATHS |
| 2 379 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 750 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 1 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 374 389 535 539 539 549 570 610 615 690 |
| 692 |
| CENSORED DEATHS |
| 3 |
| |
==================================================================================
CARVONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 94.0 88.0 80.0 70.0 54.0 28.0 |
|CONTROL | |
| | |
|375 | 100.0 100.0 100.0 98.0 98.0 95.9 91.7 81.3 66.7 60.4 |
|MG/KG | |
| | |
|750 | 100.0 100.0 100.0 100.0 95.9 95.9 89.8 85.7 81.6 77.6 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 375 750 |
| CONTROL MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 28.0% 60.4% 77.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.006N P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 604.0 583.7 554.7 |
|NATURAL DEATHS (C) | (16.1) (22.2) (30.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 639.0 652.3 676.1 |
|(STANDARD ERROR) | (14.0) (19.4) (18.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
CARVONE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
375 MG/KG = 2
750 MG/KG = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 12
|
| 3 3 12 1 2
| 3 1 231 2
P 95 +
E | 31 32 1 2
R | 1 1 2 2
C | 3 3
E 90 + 1 2 1 2
N | 3 3
T | 1 13 22
| 1 1 2 2
S 85 + 3 3
U | 1 1 2 2
R | 1 1 33
V | 3 3
I 80 + 1 1
V | 3 3
A | 11
L | 11
75 +
| 1 1
|
|
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.
CARVONE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
375 MG/KG = 2
750 MG/KG = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
| 2 3 3 11 2
| 3 1 1 22 3
| 1 1 2 2
90 + 1 1 3 2 2
| 1 1 3 232
| 1 1 1 322 3
| 2 223 3
P 80 + 1 1 22
E | 1 1 2 2 3 3
R | 1 1
C | 11 2 2
E 70 + 11 22 2
N | 11 2 2
T | 1 1 1 2 2
| 2 2
S 60 + 11 2 2
U | 11
R | 1 1
V | 11
I 50 + 11
V | 11
A |
L | 11
40 + 11
|
| 11
|
30 +
| 1 1
|
|
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.
--multipart-boundary
Content-type: text/plain
Range: bytes 24731-24731/24731
--multipart-boundary--