TR 382 Mouse Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
FURFURAL
NTP Experiment-Test: 05005-08 Report: PEIRPT05
Study Type: CHRONIC Date: 09/03/94
Route: GAVAGE Time: 06:46:19
Facility: Southern Research Institute
Chemical CAS #: 98-01-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund 8 11 9 7
Dead 8 8 11 11
Dosing Accident 1
Natural Death 1 1
Accident 2
Survivors
Terminal Sacrifice 32 28 29 32
Terminal Sacrifice 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (46) (46) (48) (43)
Intestine Small, Duodenum (46) (48) (45) (49)
Polyp Adenomatous 1 (2%) 1 (2%)
Intestine Small, Ileum (49) (47) (48) (49)
Intestine Small, Jejunum (48) (48) (46) (50)
Liver (50) (50) (50) (50)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 4 (8%) 2 (4%) 4 (8%)
Hepatocellular Adenoma 1 (2%) 3 (6%) 5 (10%) 8 (16%)
Histiocytic Sarcoma, Metastatic 1 (2%)
Mesentery (6) (10) (7) (11)
Hemangioma 1 (10%)
Pancreas (50) (50) (48) (50)
Histiocytic Sarcoma 1 (2%)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Squamous Cell Papilloma 1 (2%) 1 (2%) 6 (12%)
Stomach, Glandular (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50) (50)
Adenoma 1 (2%)
Adrenal Gland, Medulla (50) (50) (50) (50)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (50) (50) (48) (50)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (46) (49) (49) (49)
Pars Distalis, Adenoma 7 (15%) 3 (6%) 4 (8%) 9 (18%)
Pars Distalis, Fibrosarcoma, Extension,
Metastatic, Skin 1 (2%)
Thyroid Gland (50) (50) (49) (50)
Follicular Cell, Adenoma 1 (2%) 2 (4%)
Follicular Cell, Adenoma, Cystic 2 (4%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (48) (49) (50) (50)
Carcinoma 1 (2%)
Cystadenoma, Papillary 2 (4%) 1 (2%) 1 (2%)
Mixed Tumor Benign 1 (2%)
Teratoma 1 (2%)
Yolk Sac Carcinoma 1 (2%)
Uterus (50) (50) (50) (50)
Leiomyoma 1 (2%)
Polyp Stromal 1 (2%) 1 (2%)
Sarcoma Stromal 1 (2%)
Cervix, Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (49) (50)
Hemangiosarcoma 1 (2%) 1 (2%)
Lymph Node (50) (50) (50) (50)
Pancreatic, Histiocytic Sarcoma 1 (2%)
Lymph Node, Mandibular (47) (47) (49) (48)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Lymph Node, Mesenteric (48) (46) (49) (48)
Spleen (50) (50) (50) (50)
Page 3
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Hemangiosarcoma 1 (2%) 1 (2%)
Hemangiosarcoma, Multiple 1 (2%)
Thymus (49) (47) (44) (46)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (48)
Adenoacanthoma 1 (2%)
Adenocarcinoma 1 (2%) 1 (2%) 1 (2%)
Adenocarcinoma, Multiple, Two 1 (2%)
Skin (50) (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (2%) 2 (4%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Cranium, Fibrosarcoma, Extension, Metastatic,
Skin 1 (2%)
Skeletal Muscle (1) (3) (1)
Carcinoma, Metastatic, Harderian Gland 1 (33%)
Hemangiosarcoma 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Meninges, Fibrosarcoma, Extension,
Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 3 (6%) 1 (2%) 1 (2%) 3 (6%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple, Two 1 (2%)
Carcinoma, Multiple, Metastatic, Four,
Harderian Gland 1 (2%)
Nose (50) (50) (50) (50)
Lumen, Carcinoma, Metastatic, Harderian Gland 1 (2%)
Page 4
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Trachea (50) (50) (49) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (1) (2)
Adenoma 2 (100%)
Carcinoma 1 (100%)
Fibrosarcoma, Extension, Metastatic, Skin 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cortex, Adenoma 1 (2%)
Urinary Bladder (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 2 (4%)
Lymphoma Malignant Histiocytic 1 (2%) 1 (2%)
Lymphoma Malignant Lymphocytic 2 (4%) 2 (4%)
Lymphoma Malignant Mixed 8 (16%) 10 (20%) 7 (14%) 8 (16%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 33 26 24 31
Total Primary Neoplasms 45 37 32 51
Total Animals with Benign Neoplasms 16 14 16 23
Total Benign Neoplasms 21 14 18 33
Total Animals with Malignant Neoplasms 22 20 12 16
Total Malignant Neoplasms 24 23 14 18
Total Animals with Metastatic Neoplasms 2 2
Total Metastatic Neoplasm 6 5
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Dead 9 12 13 8
Moribund 6 8 12 8
Natural Death 1
Accident 1
Accidently Killed 5
Dosing Accident 2
Survivors
Terminal Sacrifice 35 28 24 27
Missing 1
Animals Examined Microscopically 50 50 49 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (46) (44) (43) (42)
Intestine Large, Cecum (49) (47) (49) (46)
Intestine Large, Rectum (48) (49) (49) (48)
Intestine Small, Ileum (45) (47) (48) (47)
Intestine Small, Jejunum (47) (46) (47) (45)
Polyp Adenomatous 1 (2%)
Liver (50) (50) (49) (50)
Carcinoma, Metastatic 1 (2%)
Fibrosarcoma, Extension, Metastatic,
Mesentery 1 (2%)
Hemangioma 1 (2%)
Hemangiosarcoma 2 (4%) 4 (8%) 2 (4%)
Hemangiosarcoma, Multiple, Two 1 (2%)
Hemangiosarcoma, Multiple, Four 1 (2%)
Hepatoblastoma 1 (2%) 1 (2%) 1 (2%)
Hepatocellular Carcinoma 6 (12%) 12 (24%) 5 (10%) 15 (30%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Carcinoma, Multiple, Two 1 (2%) 1 (2%) 4 (8%)
Hepatocellular Carcinoma, Multiple, Three 1 (2%)
Hepatocellular Adenoma 9 (18%) 12 (24%) 7 (14%) 14 (28%)
Hepatocellular Adenoma, Multiple, Two 4 (8%) 2 (4%)
Hepatocellular Adenoma, Multiple, Three 1 (2%) 2 (4%)
Hepatocellular Adenoma, Two 1 (2%)
Squamous Cell Carcinoma, Metastatic, Stomach 1 (2%)
Mesentery (4) (3) (5) (5)
Carcinoma, Metastatic 1 (20%)
Fibrosarcoma, Extension, Metastatic, Skin 1 (20%)
Fibrosarcoma, Multiple, Greater Than Five 1 (20%)
Page 7
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Pancreas (50) (50) (49) (49)
Fibrosarcoma, Extension, Metastatic,
Mesentery 1 (2%)
Salivary Glands (50) (50) (49) (50)
Fibrosarcoma, Extension, Metastatic, Skin 1 (2%) 1 (2%) 2 (4%)
Stomach, Forestomach (50) (49) (49) (49)
Adenocarcinoma 1 (2%)
Fibrosarcoma, Metastatic, Mesentery 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Stomach, Glandular (50) (49) (49) (49)
Carcinoma, Metastatic, Seminal Vesicle 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (49) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Carcinoma, Metastatic 1 (2%)
Hemangiosarcoma 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (49) (50)
Capsule, Fibrosarcoma, Extension, Metastatic,
Mesentery 1 (2%)
Spindle Cell, Adenoma 1 (2%)
Adrenal Gland, Medulla (50) (50) (48) (50)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 2 (4%) 4 (8%) 2 (4%) 1 (2%)
Pheochromocytoma Benign, Multiple 1 (2%)
Islets, Pancreatic (50) (48) (49) (49)
Adenoma 1 (2%)
Pituitary Gland (47) (45) (46) (49)
Pars Distalis, Adenoma 2 (4%)
Thyroid Gland (49) (50) (48) (50)
Follicular Cell, Adenoma 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (4) (5) (2) (2)
Epididymis (50) (50) (49) (50)
Penis (1)
Fibrosarcoma 1 (100%)
Preputial Gland (9) (10) (14) (8)
Squamous Cell Papilloma 1 (7%)
Prostate (50) (50) (48) (49)
Seminal Vesicle (50) (50) (48) (50)
Carcinoma 1 (2%)
Fibrosarcoma, Extension, Metastatic,
Mesentery 1 (2%)
Testes (50) (50) (49) (50)
Interstitial Cell, Adenoma 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (49) (50)
Hemangiosarcoma 1 (2%) 2 (4%) 1 (2%)
Lymph Node (50) (50) (49) (50)
Axillary, Histiocytic Sarcoma 1 (2%)
Iliac, Histiocytic Sarcoma 1 (2%)
Inguinal, Histiocytic Sarcoma 1 (2%)
Inguinal, Squamous Cell Carcinoma,
Metastatic, Skin 1 (2%)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Mediastinal, Carcinoma, Metastatic 1 (2%)
Mediastinal, Carcinoma, Metastatic, Seminal
Vesicle 1 (2%)
Mediastinal, Fibrosarcoma, Metastatic,
Mesentery 1 (2%)
Pancreatic, Histiocytic Sarcoma 1 (2%)
Pancreatic, Squamous Cell Carcinoma,
Metastatic, Stomach 1 (2%)
Renal, Histiocytic Sarcoma 1 (2%)
Lymph Node, Mandibular (44) (46) (47) (48)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (49) (45) (49) (50)
Fibrosarcoma, Metastatic, Spleen 1 (2%)
Histiocytic Sarcoma 1 (2%)
Spleen (50) (50) (48) (49)
Fibrosarcoma 1 (2%)
Hemangiosarcoma 2 (4%) 2 (4%)
Thymus (47) (42) (44) (45)
Histiocytic Sarcoma 1 (2%)
Page 9
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (49) (50)
Basal Cell Adenoma 1 (2%)
Keratoacanthoma 1 (2%)
Squamous Cell Carcinoma 1 (2%) 2 (4%)
Squamous Cell Papilloma 2 (4%)
Subcutaneous Tissue, Fibroma 3 (6%) 1 (2%) 2 (4%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 6 (12%) 10 (20%) 2 (4%)
Subcutaneous Tissue, Fibrosarcoma, Multiple 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (3) (2) (1)
Alveolar/Bronchiolar Carcinoma, Multiple,
Metastatic, Two, Lung 1 (33%)
Fibrosarcoma, Extension, Metastatic,
Mesentery 1 (50%)
Fibrosarcoma, Extension, Metastatic, Skin 1 (50%)
Hemangiosarcoma 1 (33%)
Sarcoma 1 (100%)
Abdominal, Carcinoma, Metastatic, Seminal
Vesicle 1 (33%)
Diaphragm, Carcinoma, Metastatic, Seminal
Vesicle 1 (33%)
Intercostal, Carcinoma, Metastatic, Seminal
Vesicle 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (49) (50)
Meningioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49) (50)
Alveolar/Bronchiolar Adenoma 9 (18%) 3 (6%) 2 (4%) 8 (16%)
Alveolar/Bronchiolar Carcinoma 3 (6%) 4 (8%) 2 (4%) 6 (12%)
Alveolar/Bronchiolar Carcinoma, Multiple,
Greater Than Five 1 (2%) 1 (2%)
Carcinoma, Multiple, Metastatic, Greater
Than Five 1 (2%)
Carcinoma, Multiple, Metastatic, Greater
Than Five, Seminal Vesicle 1 (2%)
Fibrosarcoma, Multiple, Metastatic, Greater
Than Five, Skin 1 (2%)
Fibrosarcoma, Metastatic 1 (2%)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma, Multiple,
Metastatic, Two, Liver 1 (2%)
Hepatocellular Carcinoma, Multiple,
Metastatic, Four, Liver 1 (2%)
Hepatocellular Carcinoma, Multiple,
Metastatic, Greater Than Five, Liver 1 (2%) 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (4%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Mediastinum, Carcinoma, Multiple, Metastatic,
Greater Than Five, Seminal Vesicle 1 (2%)
Mediastinum, Fibrosarcoma, Metastatic,
Mesentery 1 (2%)
Nose (49) (50) (49) (50)
Polyp 1 (2%)
Trachea (50) (50) (48) (50)
Retinoblastoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2) (2) (1)
Adenoma 2 (100%) 1 (50%) 1 (100%)
Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Carcinoma, Metastatic, Seminal Vesicle 1 (2%)
Cortex, Adenoma 1 (2%) 1 (2%)
Cortex, Carcinoma 1 (2%)
Cortex, Carcinoma, Metastatic 1 (2%)
Urinary Bladder (49) (50) (49) (49)
Page 11
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(49) *(50)
Histiocytic Sarcoma 1 (2%)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Lymphocytic 2 (4%) 2 (4%) 1 (2%)
Lymphoma Malignant Mixed 3 (6%) 2 (4%) 5 (10%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 05005-08 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 06:46:19
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE 50. 100. 175.
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 38 41 42 42
Total Primary Neoplasms 60 70 59 77
Total Animals with Benign Neoplasms 24 24 20 30
Total Benign Neoplasms 28 29 24 37
Total Animals with Malignant Neoplasms 22 31 27 32
Total Malignant Neoplasms 32 41 35 40
Total Animals with Metastatic Neoplasms 3 6 5 6
Total Metastatic Neoplasm 4 16 15 13
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 13
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 78422-78422/78422
--multipart-boundary--