TR 382 Mouse Pathology Tables
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
Facility: Southern Research Institute
Chemical CAS #: 98-01-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 9| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 3| 3| 3|
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 8| 4| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Focal Cellular Change | |
Granuloma, Multiple | 1 |
Hematopoietic Cell Proliferation | |
Necrosis, Focal | 2 |
Sinusoid, Infiltration Cellular, | |
Polymorphonuclear | 3 3 3 |
__________________________________________________________________________|
Mesentery | + + |
Abscess | 4 |
Inflammation, Acute, Suppurative | |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
Acinus, Atrophy, Multifocal | 4 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty, Focal | 2 |
Hyperplasia, Focal | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 9| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 3| 3| 3|
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 8| 4| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + M + M + + + + + + + M + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 2|
Pars Distalis, Hyperplasia, Focal | 2 1 2 2 2 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 |
Follicle, Cyst | X |
Follicle, Degeneration, Cystic | 1 1 1 1 1 3 |
Follicular Cell, Hyperplasia, Cystic,| |
Focal | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + M + + + + + + + + + M + + + + + + +|
Abscess | 4 4 4 |
Cyst | X X X X |
Cyst, Two | X |
Hyperplasia, Tubular | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 2 |
Inflammation, Acute, Suppurative | |
Endometrium, Hyperplasia, Cystic | 3 3 3 2 2 2 4 3 3 2 3 4 2 3 3 1 3 4 2 3 3 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukocytosis | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 2 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 4 3 4 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 9| 4| 3| 3| 3| 3| 3| 3| 3| 9| 9| 3| 3| 3|
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 6| 8| 4| 1| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Inflammation, Acute, | |
Suppurative | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Infiltration Cellular, Multifocal, | |
Histiocyte | 3 |
Mediastinum, Foreign Body | |
Mediastinum, Inflammation, Acute, | |
Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Foreign Body | 4 |
Nasolacrimal Duct, Inflammation, | |
Subacute | 1 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Multifocal, | |
Suppurative | 3 |
Metaplasia, Focal, Osseous | 1 |
Nephropathy, Chronic | 1 1 1 1 1 2 1 1 1 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 0| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 6| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 7| 3| 3| 3| 2| 6| 3| 3| 3| 0| 4| 7| 3| 3| 4| 7| 3| 3| 3| 3| 4| 3| 3| 3| |
| 1| 3| 1| 1| 1| 0| 2| 1| 2| 2| 5| 8| 1| 2| 2| 3| 6| 2| 2| 2| 0| 8| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + M + + + M + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + M + + + A + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | | 1 2.0|
Focal Cellular Change | X | 1 |
Granuloma, Multiple | | 1 1.0|
Hematopoietic Cell Proliferation | 2 2 2 3 2 | 5 2.2|
Necrosis, Focal | 3 | 2 2.5|
Sinusoid, Infiltration Cellular, | | |
Polymorphonuclear | 2 2 2 | 6 2.5|
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Abscess | | 1 4.0|
Inflammation, Acute, Suppurative | 3 2 | 2 2.5|
Fat, Necrosis, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2 1 1 1| 6 1.2|
Acinus, Atrophy, Multifocal | | 1 4.0|
Duct, Cyst | X X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 2 1 1 1 1 1 1 1| 24 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 0| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 6| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 7| 3| 3| 3| 2| 6| 3| 3| 3| 0| 4| 7| 3| 3| 4| 7| 3| 3| 3| 3| 4| 3| 3| 3| |
| 1| 3| 1| 1| 1| 0| 2| 1| 2| 2| 5| 8| 1| 2| 2| 3| 6| 2| 2| 2| 0| 8| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty, Focal | | 1 2.0|
Hyperplasia, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 46 |
Pars Distalis, Angiectasis | 2 | 5 2.0|
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 | 12 1.9|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 1 | 2 1.5|
Follicle, Cyst | X | 2 |
Follicle, Degeneration, Cystic | 1 1 2 1 1 1 1 2| 14 1.3|
Follicular Cell, Hyperplasia, Cystic,| | |
Focal | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Abscess | 4 4 4 2 4 4 | 9 3.8|
Cyst | X X X | 7 |
Cyst, Two | | 1 |
Hyperplasia, Tubular | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 1 2 2 | 6 1.8|
Inflammation, Acute, Suppurative | 2 2 | 2 2.0|
Endometrium, Hyperplasia, Cystic | 3 3 2 2 3 3 3 2 2 2 2 2 3 2 2 3 2 3 1 3| 43 2.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 2 |
Leukocytosis | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 0| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 6| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 7| 3| 3| 3| 2| 6| 3| 3| 3| 0| 4| 7| 3| 3| 4| 7| 3| 3| 3| 3| 4| 3| 3| 3| |
| 1| 3| 1| 1| 1| 0| 2| 1| 2| 2| 5| 8| 1| 2| 2| 3| 6| 2| 2| 2| 0| 8| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia | 4 3 4 3 2 3 | 8 3.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Hyperplasia, Lymphoid | 4 | 1 4.0|
Mediastinal, Hyperplasia, Lymphoid | 4 | 1 4.0|
Renal, Hyperplasia, Lymphoid | 4 | 2 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + + + M + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 2 2 2 2 2 | 12 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 4 2 4 3 4 4 3 4 4 4 3 | 16 3.6|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Cyst | X X | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Inflammation, Acute, | | |
Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 1 | 2 2.0|
Mediastinum, Foreign Body | 4 | 1 4.0|
Mediastinum, Inflammation, Acute, | | |
Suppurative | 4 4 2 | 3 3.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Foreign Body | | 1 4.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | | 4 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 0| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 6| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 1| 7| 3| 3| 3| 2| 6| 3| 3| 3| 0| 4| 7| 3| 3| 4| 7| 3| 3| 3| 3| 4| 3| 3| 3| |
| 1| 3| 1| 1| 1| 0| 2| 1| 2| 2| 5| 8| 1| 2| 2| 3| 6| 2| 2| 2| 0| 8| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Multifocal, | | |
Suppurative | | 1 3.0|
Metaplasia, Focal, Osseous | | 1 1.0|
Nephropathy, Chronic | 3 1 1 2 1 1 1 1 3 1 1 1 | 24 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 1 1| 7 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 2| 8| 1| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 4| 3| 3| 3| 3|
| 2| 1| 1| 1| 1| 6| 6| 5| 4| 1| 1| 1| 1| 1| 1| 2| 0| 1| 1| 1| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X X |
Hematopoietic Cell Proliferation | 2 |
Necrosis, Multifocal | |
Vacuolization Cytoplasmic, Diffuse | |
Serosa, Subserosa, Inflammation, | |
Chronic, Multifocal | 1 1 1 |
Serosa, Subserosa, Pigmentation, | |
Multifocal | 1 1 1 1 1 1 |
Sinusoid, Infiltration Cellular, | |
Polymorphonuclear | |
Subserosa, Inflammation, Chronic, | |
Multifocal | |
Subserosa, Pigmentation, Multifocal | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Acute, Suppurative | |
Inflammation, Subacute | 3 |
Fat, Necrosis, Focal | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 2 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 3 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 2| 8| 1| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 4| 3| 3| 3| 3|
| 2| 1| 1| 1| 1| 6| 6| 5| 4| 1| 1| 1| 1| 1| 1| 2| 0| 1| 1| 1| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2|
Capsule, Accessory Adrenal Cortical | |
Nodule | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 2 1 2 2|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 2 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X |
Follicle, Degeneration, Cystic | 2 2 2 2 2 2 |
Follicular Cell, Hyperplasia, Cystic,| |
Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | X X X X X X X X X|
Hemorrhage | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 3 2 |
Inflammation, Acute, Suppurative | 2 |
Endometrium, Hyperplasia, Cystic | 4 3 3 3 3 3 3 4 3 3 4 2 3 4 2 4 3 4 4 4 4 4 3 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 2| 8| 1| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 4| 3| 3| 3| 3|
| 2| 1| 1| 1| 1| 6| 6| 5| 4| 1| 1| 1| 1| 1| 1| 2| 0| 1| 1| 1| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Hyperplasia, Lymphoid | 4 |
Mediastinal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 4 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 3 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 4 2 4 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin, Multifocal| |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Mediastinum, Inflammation, Subacute | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Subacute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 3| 7| 7| 7| 7| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 2| 8| 1| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 4| 3| 3| 3| 3|
| 2| 1| 1| 1| 1| 6| 6| 5| 4| 1| 1| 1| 1| 1| 1| 2| 0| 1| 1| 1| 2| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
175 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Fibrosis, Focal | 1 2 |
Nephropathy, Chronic | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
Renal Tubule, Dilatation, Multifocal | |
Renal Tubule, Pigmentation, | |
Hemosiderin, Multifocal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 2| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 9| 3| 3| 3| 1| 3| 3| 3| 3| 0| 1| 3| 5| 5| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| |
| 6| 6| 1| 1| 1| 4| 1| 1| 1| 1| 1| 5| 3| 4| 4| 9| 3| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
175 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + + + + + + + M M M M + + M + M + +| 43 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Focal Cellular Change | | 2 |
Hematopoietic Cell Proliferation | 1 2 1 | 4 1.5|
Necrosis, Multifocal | 2 1 | 2 1.5|
Vacuolization Cytoplasmic, Diffuse | 2 | 1 2.0|
Serosa, Subserosa, Inflammation, | | |
Chronic, Multifocal | 1 1 2| 6 1.2|
Serosa, Subserosa, Pigmentation, | | |
Multifocal | 1 1 1 1| 10 1.0|
Sinusoid, Infiltration Cellular, | | |
Polymorphonuclear | 3 2 | 2 2.5|
Subserosa, Inflammation, Chronic, | | |
Multifocal | 1 1 | 2 1.0|
Subserosa, Pigmentation, Multifocal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + +| 11 |
Inflammation, Acute, Suppurative | 2 3 | 2 2.5|
Inflammation, Subacute | | 1 3.0|
Fat, Necrosis, Focal | 2 3 2 2 2| 7 2.4|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 1 1| 10 1.1|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 1 2 1 1 1 1 1| 23 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 2| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 9| 3| 3| 3| 1| 3| 3| 3| 3| 0| 1| 3| 5| 5| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| |
| 6| 6| 1| 1| 1| 4| 1| 1| 1| 1| 1| 5| 3| 4| 4| 9| 3| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
175 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | 2 | 2 2.5|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 | 2 2.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + M + + + + + + + + + + + + + + + M + + +| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
Pars Distalis, Angiectasis | 2 2 4 2 | 11 2.1|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Cyst | X X X| 4 |
Follicle, Degeneration, Cystic | 2 1 1 2 2 2 | 12 1.8|
Follicular Cell, Hyperplasia, Cystic,| | |
Focal | 2 3 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 2 4 | 3 3.3|
Cyst | X X X | 12 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 2| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 9| 3| 3| 3| 1| 3| 3| 3| 3| 0| 1| 3| 5| 5| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| |
| 6| 6| 1| 1| 1| 4| 1| 1| 1| 1| 1| 5| 3| 4| 4| 9| 3| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
175 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hydrometra | | 2 2.5|
Inflammation, Acute, Suppurative | 2 | 2 2.0|
Endometrium, Hyperplasia, Cystic | 1 4 4 4 3 2 1 4 2 3 3 2 2 3 2 2 3 3 3 2 3 3 3| 48 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
Leukocytosis | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 1 1 1 | 8 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Hyperplasia, Lymphoid | | 1 4.0|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Renal, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 2 3 3 2 | 7 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + M + + +| 48 |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 | 13 2.2|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 4 3 3 2 3 1 | 11 2.9|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + + M + M + + + + + + + +| 46 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + M + M + + + + + + + + +| 48 |
Duct, Cyst | X X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibrosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 | 1 2.0|
Hemorrhage, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 2| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 9| 3| 3| 3| 1| 3| 3| 3| 3| 0| 1| 3| 5| 5| 4| 4| 3| 3| 3| 3| 3| 3| 3| 3| |
| 6| 6| 1| 1| 1| 4| 1| 1| 1| 1| 1| 5| 3| 4| 4| 9| 3| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
175 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Pigmentation, Hemosiderin, Multifocal| 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 3 | 1 3.0|
Mediastinum, Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Inflammation, | | |
Subacute | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 4 | 1 4.0|
Fibrosis, Focal | | 2 1.5|
Nephropathy, Chronic | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 35 1.1|
Renal Tubule, Dilatation, Multifocal | 3 | 1 3.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 1 | 6 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 5| 7| 7| 7| 7| 3| 4| 5| 7| 7| 4| 5| 5| 6| 6| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 2| 2| 2| 6| 2| 2| 2| 2| 6| 9| 1| 2| 2| 8| 7| 7| 4| 7| 3| 1| 2| 2| 2|
| 8| 6| 9| 9| 9| 8| 9| 9| 9| 9| 0| 3| 4| 9| 9| 8| 4| 5| 8| 5| 6| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + M + M + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + M A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + A + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + M A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + A + + +|
Inflammation, Focal, Subacute | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Focal Cellular Change | X |
Granuloma, Multiple | |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Lymphocyte | 2 |
Necrosis, Multifocal | |
Kupffer Cell, Pigmentation, | |
Multifocal | 1 |
Sinusoid, Infiltration Cellular, | |
Polymorphonuclear | 3 2 4 3 2 2 2 3 3 2 |
Subserosa, Inflammation, Chronic, | |
Multifocal | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Acute, Suppurative | 3 |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
Inflammation, Acute, Suppurative | 2 2 2 |
Acinus, Atrophy, Multifocal | |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 1 |
Inflammation, Subacute | 2 2 2 |
Ulcer | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Multiple | |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 5| 7| 7| 7| 7| 3| 4| 5| 7| 7| 4| 5| 5| 6| 6| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 2| 2| 2| 6| 2| 2| 2| 2| 6| 9| 1| 2| 2| 8| 7| 7| 4| 7| 3| 1| 2| 2| 2|
| 8| 6| 9| 9| 9| 8| 9| 9| 9| 9| 0| 3| 4| 9| 9| 8| 4| 5| 8| 5| 6| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 3 |
Inflammation, Focal, Subacute | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | |
Spindle Cell, Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Pars Distalis, Angiectasis | 2 1 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | |
Follicle, Cyst | X X |
Follicle, Degeneration, Cystic | 2 1 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 4 4 4 4 4 4 4 4 |
Cyst | X X X X X |
Hyperplasia, Tubular | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hydrometra | 2 3 |
Inflammation, Acute, Suppurative | 3 4 2 3 2 |
Endometrium, Hyperplasia, Cystic | 1 3 2 2 3 1 2 3 2 3 3 3 2 2 3 2 2 2 2 2 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 5| 7| 7| 7| 7| 3| 4| 5| 7| 7| 4| 5| 5| 6| 6| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 2| 2| 2| 6| 2| 2| 2| 2| 6| 9| 1| 2| 2| 8| 7| 7| 4| 7| 3| 1| 2| 2| 2|
| 8| 6| 9| 9| 9| 8| 9| 9| 9| 9| 0| 3| 4| 9| 9| 8| 4| 5| 8| 5| 6| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood | + |
Leukocytosis | 2 |
Polychromasia | 2 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + I + + + + + + + + +|
Hyperplasia | 2 2 3 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Inflammation, Acute, | |
Suppurative | 3 |
Renal, Hyperplasia, Lymphoid | 2 4 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 3 2 3 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 4 4 4 4 2 4 3 3 4 4 4 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + M + + + + + + + + +|
Cyst | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Acute, Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, | |
Polymorphonuclear | 3 |
Inflammation, Acute, Multifocal, | |
Suppurative | 3 |
Mediastinum, Inflammation, Acute, | |
Suppurative | 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 7| 5| 7| 7| 7| 7| 3| 4| 5| 7| 7| 4| 5| 5| 6| 6| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 0| 2| 2| 2| 6| 2| 2| 2| 2| 6| 9| 1| 2| 2| 8| 7| 7| 4| 7| 3| 1| 2| 2| 2|
| 8| 6| 9| 9| 9| 8| 9| 9| 9| 9| 0| 3| 4| 9| 9| 8| 4| 5| 8| 5| 6| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
100 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | 2 |
Nasolacrimal Duct, Inflammation, | |
Subacute | 2 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Harderian Gland | + |
Cyst | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Multifocal, | |
Suppurative | 3 |
Nephropathy, Chronic | 1 1 1 1 1 1 1 2 1 1 2 4 2 1 1 2|
Renal Tubule, Dilatation, Multifocal | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 9| 2| 6| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 9| 1| 3| 3| 3| 0| 9| 3| 3| 3| |
| 0| 3| 2| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 4| 1| 2| 2| 2| 5| 3| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
100 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + A + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + A + + +| 46 |
Inflammation, Focal, Subacute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 | 1 4.0|
Focal Cellular Change | X | 2 |
Granuloma, Multiple | 1| 1 1.0|
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Necrosis, Multifocal | 3 1 1 | 3 1.7|
Kupffer Cell, Pigmentation, | | |
Multifocal | | 1 1.0|
Sinusoid, Infiltration Cellular, | | |
Polymorphonuclear | 2 3 2 2 | 14 2.5|
Subserosa, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 7 |
Inflammation, Acute, Suppurative | 4 2 | 3 3.0|
Fat, Necrosis, Focal | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 1 | 5 1.0|
Inflammation, Acute, Suppurative | 2 | 4 2.0|
Acinus, Atrophy, Multifocal | 3 | 1 3.0|
Duct, Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 21 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 5 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 9| 2| 6| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 9| 1| 3| 3| 3| 0| 9| 3| 3| 3| |
| 0| 3| 2| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 4| 1| 2| 2| 2| 5| 3| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
100 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Subacute | 2 | 4 2.0|
Ulcer | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion, Multiple | 2 | 1 2.0|
Mineralization | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Focal | | 1 3.0|
Inflammation, Focal, Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 2 3.0|
Hyperplasia, Focal | 2 | 2 2.0|
Hypertrophy, Focal | 2 | 1 2.0|
Spindle Cell, Hyperplasia, Focal | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + M + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 2 3 1 2| 6 1.8|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 1 2 | 9 1.6|
__________________________________________________________________________|____________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia, Focal | 2 | 1 2.0|
Follicle, Cyst | X | 3 |
Follicle, Degeneration, Cystic | 2 1 1 1 2 2 | 11 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 4 4 4 4 | 15 4.0|
Cyst | X X X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 9| 2| 6| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 9| 1| 3| 3| 3| 0| 9| 3| 3| 3| |
| 0| 3| 2| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 4| 1| 2| 2| 2| 5| 3| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
100 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia, Tubular | 4 | 1 4.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Hydrometra | 2 | 3 2.3|
Inflammation, Acute, Suppurative | 3 4 2 | 8 2.9|
Endometrium, Hyperplasia, Cystic | 2 1 2 3 3 3 2 2 2 2 3 2 2 3 3 3 3 3 3 3 2 3| 44 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Leukocytosis | | 1 2.0|
Polychromasia | | 1 2.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 3 2 | 11 2.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Inflammation, Acute, | | |
Suppurative | | 1 3.0|
Renal, Hyperplasia, Lymphoid | 3 3 | 5 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 1 2 2 1 2 3 | 13 2.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 4 2 3 4 4 4 2 | 19 3.4|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + M + + + + + + + + + + + + M M + + + + + + + +| 44 |
Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Cyst | X| 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 9| 2| 6| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 9| 1| 3| 3| 3| 0| 9| 3| 3| 3| |
| 0| 3| 2| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 4| 1| 2| 2| 2| 5| 3| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
100 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Inflammation, Acute, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
Inflammation, Acute, Multifocal, | | |
Suppurative | | 1 3.0|
Mediastinum, Inflammation, Acute, | | |
Suppurative | 2 | 3 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | | 4 1.5|
__________________________________________________________________________|____________|
Trachea | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Multifocal, | | |
Suppurative | | 1 3.0|
Nephropathy, Chronic | 3 1 1 1 1 1 1 1 1 1 2 2 2 1 1 1 2| 33 1.4|
Renal Tubule, Dilatation, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2 1 1 1 1 1 | 9 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 4| 4| 6| 7| 7| 4| 7| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 9| 3| 3| 3| 4| 1| 1| 3| 9| 1| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 0| 4| 3| 2| 2| 4| 5| 6| 9| 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
50 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + M + + + + M + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Focal Cellular Change | X X|
Granuloma, Multiple | 1 1 1 |
Hematopoietic Cell Proliferation | 2 2 3 |
Infiltration Cellular, Megakaryocyte | 4 |
Necrosis, Multifocal | 2 |
Vacuolization Cytoplasmic, Diffuse | |
Kupffer Cell, Hyperplasia | |
Kupffer Cell, Pigmentation, | |
Multifocal | 2 |
Sinusoid, Infiltration Cellular, | |
Polymorphonuclear | 3 2 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Subacute | 3 |
Fat, Necrosis, Focal | 3 |
Fat, Necrosis, Multifocal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 1 |
Inflammation, Acute, Suppurative | 2 |
Acinus, Atrophy, Focal | |
Acinus, Atrophy, Multifocal | 2 2 4 |
Acinus, Necrosis, Focal | 2 |
Duct, Cyst | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Hyperplasia, Focal | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 2 1 1 1 1 1 1 2|
Pigmentation, Focal, Hemosiderin | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 4| 4| 6| 7| 7| 4| 7| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 9| 3| 3| 3| 4| 1| 1| 3| 9| 1| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 0| 4| 3| 2| 2| 4| 5| 6| 9| 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
50 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis, Focal | 3 |
Hyperplasia | 2 2 2|
Inflammation, Subacute | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Inflammation, Focal, Subacute | 2 |
Mineralization, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 2 4 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
Follicle, Cyst | |
Follicle, Degeneration, Cystic | 2 1 1 1 2 1 1 |
Follicular Cell, Hyperplasia, Cystic,| |
Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 4 |
Angiectasis | 2 |
Cyst | X X X X X X|
Cyst, Two | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 4| 4| 6| 7| 7| 4| 7| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 9| 3| 3| 3| 4| 1| 1| 3| 9| 1| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 0| 4| 3| 2| 2| 4| 5| 6| 9| 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
50 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hydrometra | 2 2 2 |
Inflammation, Acute, Suppurative | 2 4 4 |
Endometrium, Hyperplasia, Cystic | 4 3 4 3 3 2 2 3 3 2 2 2 4 3 3 3 2 3 2 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Leukocytosis | 2 |
Polychromasia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 3 1 3 2 |
Infiltration Cellular, Megakaryocyte | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | 3 3 3 |
Mediastinal, Inflammation, Acute, | |
Suppurative | |
Renal, Hyperplasia, Lymphoid | 3 4 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Lymphoid | 3|
Infiltration Cellular, Megakaryocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + M|
Angiectasis | 2 2 |
Hyperplasia, Lymphoid | 2 2 2 2 2 3 |
Infiltration Cellular, Megakaryocyte | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hematopoietic Cell Proliferation | 3 4 3 4 4 4 2 2 2 4 3 4 |
Infiltration Cellular, Megakaryocyte | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 4| 4| 6| 7| 7| 4| 7| 7| 7| 7| 2| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 5| 9| 3| 3| 3| 4| 1| 1| 3| 9| 1| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3|
| 0| 4| 3| 2| 2| 4| 5| 6| 9| 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
50 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Granuloma | 2 |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Megakaryocyte | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Mediastinum, Inflammation, Acute, | |
Suppurative | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Subacute | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Hyperplasia, Melanocyte | 3 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Inflammation, Acute, Multifocal, | |
Suppurative | 4 |
Metaplasia, Focal, Osseous | |
Nephropathy, Chronic | 2 2 1 2 3 1 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Degeneration, | |
Multifocal | 3 |
Renal Tubule, Mineralization, | |
Multifocal | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 2 1 1 |
Inflammation, Subacute | 3 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 3| 3| 4| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 1| 3| 3| 3| 3| 7| 7| 3| 0| 3| 0| 7| 6| 3| 3| |
| 5| 5| 5| 5| 5| 7| 9| 5| 5| 5| 5| 5| 5| 5| 5| 3| 7| 4| 4| 5| 9| 4| 4| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
50 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + M + + + + + + + + + M + + + +| 46 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 | 1 2.0|
Focal Cellular Change | | 2 |
Granuloma, Multiple | | 3 1.0|
Hematopoietic Cell Proliferation | 2 | 4 2.3|
Infiltration Cellular, Megakaryocyte | | 1 4.0|
Necrosis, Multifocal | | 1 2.0|
Vacuolization Cytoplasmic, Diffuse | 3 | 1 3.0|
Kupffer Cell, Hyperplasia | 2 | 1 2.0|
Kupffer Cell, Pigmentation, | | |
Multifocal | | 1 2.0|
Sinusoid, Infiltration Cellular, | | |
Polymorphonuclear | | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 10 |
Inflammation, Subacute | | 1 3.0|
Fat, Necrosis, Focal | | 1 3.0|
Fat, Necrosis, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 1 1 | 6 1.3|
Inflammation, Acute, Suppurative | 2 | 2 2.0|
Acinus, Atrophy, Focal | 1 | 1 1.0|
Acinus, Atrophy, Multifocal | 2 2 | 5 2.4|
Acinus, Necrosis, Focal | | 1 2.0|
Duct, Cyst | X | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 3| 3| 4| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 1| 3| 3| 3| 3| 7| 7| 3| 0| 3| 0| 7| 6| 3| 3| |
| 5| 5| 5| 5| 5| 7| 9| 5| 5| 5| 5| 5| 5| 5| 5| 3| 7| 4| 4| 5| 9| 4| 4| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
50 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Focal | 3 | 1 3.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2 1 1 2 1 1 1 1 1 2 1| 22 1.2|
Pigmentation, Focal, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 2 | 1 2.0|
Hyperkeratosis, Focal | | 1 3.0|
Hyperplasia | 2 2 | 5 2.0|
Inflammation, Subacute | 2 2 | 3 2.0|
Ulcer | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | 1 | 1 1.0|
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | | 1 2.0|
Inflammation, Focal, Subacute | 1 | 2 1.5|
Mineralization, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + M + + + + + + + + + M M + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 2 2 4 | 5 2.4|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 1 2 | 14 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X | 1 |
Follicle, Cyst | X | 1 |
Follicle, Degeneration, Cystic | 1 2 2 1 2 1| 13 1.4|
Follicular Cell, Hyperplasia, Cystic,| | |
Focal | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 3| 3| 4| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 1| 3| 3| 3| 3| 7| 7| 3| 0| 3| 0| 7| 6| 3| 3| |
| 5| 5| 5| 5| 5| 7| 9| 5| 5| 5| 5| 5| 5| 5| 5| 3| 7| 4| 4| 5| 9| 4| 4| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
50 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Abscess | 4 4 4 | 6 4.0|
Angiectasis | | 1 2.0|
Cyst | X X X X X | 11 |
Cyst, Two | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 4 | 3 2.7|
Hydrometra | 3 2 2 | 6 2.2|
Inflammation, Acute, Suppurative | 2 | 4 3.0|
Endometrium, Hyperplasia, Cystic | 2 3 3 3 3 4 3 2 3 2 3 3 3 3 4 2 2 2 2 3| 42 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
Leukocytosis | | 1 2.0|
Polychromasia | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 2 1 2 2 | 13 1.9|
Infiltration Cellular, Megakaryocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iliac, Hyperplasia, Lymphoid | | 3 3.0|
Mediastinal, Inflammation, Acute, | | |
Suppurative | 4 | 1 4.0|
Renal, Hyperplasia, Lymphoid | 3 | 5 3.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + M + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Megakaryocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + M + + + + + + + + +| 46 |
Angiectasis | | 2 2.0|
Hyperplasia, Lymphoid | 2 2 2 | 9 2.1|
Infiltration Cellular, Megakaryocyte | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Hematopoietic Cell Proliferation | 4 4 4 3 4 | 17 3.4|
Infiltration Cellular, Megakaryocyte | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + + + + M + + M + + +| 47 |
Cyst | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 3| 3| 4| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 1| 3| 3| 3| 3| 7| 7| 3| 0| 3| 0| 7| 6| 3| 3| |
| 5| 5| 5| 5| 5| 7| 9| 5| 5| 5| 5| 5| 5| 5| 5| 3| 7| 4| 4| 5| 9| 4| 4| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
50 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Cyst | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femur, Fracture | X| 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma | | 1 2.0|
Hemorrhage, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Infiltration Cellular, Megakaryocyte | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Mediastinum, Inflammation, Acute, | | |
Suppurative | 1 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Suppurative | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 3.0|
Hyperplasia, Melanocyte | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 2 2 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 3| 3| 4| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 1| 3| 3| 3| 3| 7| 7| 3| 0| 3| 0| 7| 6| 3| 3| |
| 5| 5| 5| 5| 5| 7| 9| 5| 5| 5| 5| 5| 5| 5| 5| 3| 7| 4| 4| 5| 9| 4| 4| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
50 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Acute, Multifocal, | | |
Suppurative | | 1 4.0|
Metaplasia, Focal, Osseous | 1 2 | 2 1.5|
Nephropathy, Chronic | 2 1 1 1 3 1 1 1 1 1 1 1 1 3 2 1 1 1| 33 1.3|
Renal Tubule, Degeneration, | | |
Multifocal | | 1 3.0|
Renal Tubule, Mineralization, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 | 8 1.1|
Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 5| 6| 7| 7| 7| 3| 4| 7| 7| 7| 7| 4| 7| 7| 7| 1| 6| 7| 7| 7|
DAY ON TEST | 1| 3| 6| 3| 3| 8| 2| 3| 3| 3| 7| 5| 3| 3| 3| 3| 5| 3| 3| 3| 2| 1| 3| 3| 3|
| 8| 0| 6| 0| 0| 0| 2| 0| 0| 0| 5| 6| 0| 0| 0| 0| 6| 0| 0| 0| 1| 1| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + M A + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Focal Cellular Change | |
Focal Cellular Change, Multiple | X |
Granuloma, Multiple | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Necrosis, Focal | 2 1 |
Necrosis, Multifocal | |
Vacuolization Cytoplasmic, Diffuse | 3 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Granulomatous, | |
Multifocal | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | |
Acinus, Atrophy, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 2 1 1 2 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
Inflammation, Subacute | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Mineralization | 2 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + +|
Dysplasia | 4 4 3 1 4 4 4 3 4 4 3|
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 5| 6| 7| 7| 7| 3| 4| 7| 7| 7| 7| 4| 7| 7| 7| 1| 6| 7| 7| 7|
DAY ON TEST | 1| 3| 6| 3| 3| 8| 2| 3| 3| 3| 7| 5| 3| 3| 3| 3| 5| 3| 3| 3| 2| 1| 3| 3| 3|
| 8| 0| 6| 0| 0| 0| 2| 0| 0| 0| 5| 6| 0| 0| 0| 0| 6| 0| 0| 0| 1| 1| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal | 2 2 3 |
Capsule, Accessory Adrenal Cortical | |
Nodule | 2 |
Spindle Cell, Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 2 2 2 2 1 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + M + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + M + + + +|
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | X X|
Follicle, Degeneration, Cystic | 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Dilatation | 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + |
Inflammation, Subacute | 4 4 4 |
Duct, Cyst | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukocytosis | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 5| 6| 7| 7| 7| 3| 4| 7| 7| 7| 7| 4| 7| 7| 7| 1| 6| 7| 7| 7|
DAY ON TEST | 1| 3| 6| 3| 3| 8| 2| 3| 3| 3| 7| 5| 3| 3| 3| 3| 5| 3| 3| 3| 2| 1| 3| 3| 3|
| 8| 0| 6| 0| 0| 0| 2| 0| 0| 0| 5| 6| 0| 0| 0| 0| 6| 0| 0| 0| 1| 1| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | 3 |
Inguinal, Pigmentation, Hemosiderin | |
Mediastinal, Hyperplasia, Lymphoid | 4|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 4 2 2 |
Hyperplasia, Lymphoid | 1 3 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 3 3 3 3 2 |
Hyperplasia, Lymphoid | 2 1 3 2 2 3 2 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + M + M + + + + + + +|
Cyst | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M M + M M M M M M M M M + M + M + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer, Focal | 2 |
Epidermis, Hyperplasia, Focal | 2 2 2 2 |
Epidermis, Inflammation, Acute, | |
Focal, Suppurative | 2 |
Subcutaneous Tissue, Edema, Focal | 2 |
Subcutaneous Tissue, Fibrosis, Focal | 2 2 2 2 3 1 3 2 2 |
Subcutaneous Tissue, Hemorrhage, | |
Focal | |
Subcutaneous Tissue, Inflammation, | |
Acute, Focal, Suppurative | |
Subcutaneous Tissue, Inflammation, | |
Granulomatous, Multifocal | |
Subcutaneous Tissue, Metaplasia, | |
Focal, Osseous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arthrosis, Chronic | 2 2 2 |
__________________________________________________________________________|
Skeletal Muscle | |
Abdominal, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 5| 6| 7| 7| 7| 3| 4| 7| 7| 7| 7| 4| 7| 7| 7| 1| 6| 7| 7| 7|
DAY ON TEST | 1| 3| 6| 3| 3| 8| 2| 3| 3| 3| 7| 5| 3| 3| 3| 3| 5| 3| 3| 3| 2| 1| 3| 3| 3|
| 8| 0| 6| 0| 0| 0| 2| 0| 0| 0| 5| 6| 0| 0| 0| 0| 6| 0| 0| 0| 1| 1| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage, Focal | |
Infiltration Cellular, Multifocal, | |
Histiocyte | 2 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + M + + + +|
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | 3 |
Nasolacrimal Duct, Inflammation, | |
Subacute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 1 1 2 1 1 1 1 |
Metaplasia, Focal, Osseous | |
Nephropathy, Chronic | 1 1 2 1 1 1 1 3 1 1 2 1 1 1 1 1 1|
Renal Tubule, Mineralization, | |
Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 3| 3| 0| 6| 3| 3| 3| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| |
| 0| 9| 0| 0| 0| 0| 3| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 6| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + M + + + M + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 | 1 1.0|
Focal Cellular Change | X X X | 3 |
Focal Cellular Change, Multiple | | 1 |
Granuloma, Multiple | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
Necrosis, Focal | | 2 1.5|
Necrosis, Multifocal | 4 | 1 4.0|
Vacuolization Cytoplasmic, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 4 |
Inflammation, Granulomatous, | | |
Multifocal | 2 | 1 2.0|
Fat, Necrosis, Focal | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy, Focal | 4| 1 4.0|
Acinus, Atrophy, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1| 28 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 5 2.0|
Inflammation, Subacute | 1 | 1 1.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | 2 2 2 | 3 2.0|
Mineralization | 1 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + +| 27 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 3| 3| 0| 6| 3| 3| 3| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| |
| 0| 9| 0| 0| 0| 0| 3| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 6| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Dysplasia | 1 3 2 1 4 4 4 2 3 4 3 2 1 4 3 4| 27 3.1|
Inflammation, Subacute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Hyperplasia, Focal | 2 2 2 2 | 7 2.1|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 1 2.0|
Spindle Cell, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 | 5 1.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 1 2 1 4| 14 1.8|
Pigmentation, Hemosiderin | 1 | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + M M + + + + + + + + + + M + +| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Follicle, Cyst | X X X X | 6 |
Follicle, Degeneration, Cystic | 2 1 2 1 2 1 1 1 2 1 1 1 | 17 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + +| 4 |
Dilatation | 3 2 2| 4 2.5|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 9 |
Inflammation, Subacute | 4 4 2 4 | 7 3.7|
Duct, Cyst | X X | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 3| 3| 0| 6| 3| 3| 3| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| |
| 0| 9| 0| 0| 0| 0| 3| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 6| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Subacute | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 3 2 2| 7 2.3|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Leukocytosis | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 1 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Lymphoid | 2 | 2 2.5|
Inguinal, Pigmentation, Hemosiderin | 1 | 1 1.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + + + M + + + + + M + M + + + +| 44 |
Hyperplasia, Lymphoid | 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 2 2 3 1 2 2 2 2 1| 15 2.2|
Hyperplasia, Lymphoid | 2 3 4 2 2 2 | 10 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 2 | 10 2.6|
Hyperplasia, Lymphoid | 4 3 3 3 2 2 2 3 | 16 2.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst | X X X X X | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M + + M M M M M M M M M M + + M M M M M M| 9 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer, Focal | | 1 2.0|
Epidermis, Hyperplasia, Focal | 2 | 5 2.0|
Epidermis, Inflammation, Acute, | | |
Focal, Suppurative | | 1 2.0|
Subcutaneous Tissue, Edema, Focal | | 1 2.0|
Subcutaneous Tissue, Fibrosis, Focal | 2 2 2 | 12 2.1|
Subcutaneous Tissue, Hemorrhage, | | |
Focal | 3 | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Acute, Focal, Suppurative | 4 | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 3| 3| 0| 6| 3| 3| 3| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| |
| 0| 9| 0| 0| 0| 0| 3| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 6| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Granulomatous, Multifocal | 2 | 1 2.0|
Subcutaneous Tissue, Metaplasia, | | |
Focal, Osseous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Arthrosis, Chronic | 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Abdominal, Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 2 2.5|
Hemorrhage, Focal | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 3 | 4 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 2 2 | 2 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1| 25 1.1|
Metaplasia, Focal, Osseous | 1 | 1 1.0|
Nephropathy, Chronic | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1| 37 1.2|
Renal Tubule, Mineralization, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 6| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 0| 3| 3| 3| 0| 6| 3| 3| 3| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3| |
| 0| 9| 0| 0| 0| 0| 3| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 6| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 7| 4| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 6| 6| 7|
DAY ON TEST | 3| 7| 6| 7| 3| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 8| 3| 3| 3| 3| 5| 3| 6| 3|
| 0| 5| 7| 6| 0| 8| 0| 0| 0| 0| 4| 0| 0| 0| 0| 2| 2| 0| 0| 0| 0| 6| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
175 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + M + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Focal Cellular Change | X X X |
Hematopoietic Cell Proliferation | 2|
Inclusion Body Intranuclear | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Mineralization, Focal | 2 |
Necrosis, Focal | 4 |
Necrosis, Multifocal | 4 1 3 3 |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Multifocal| 1 |
Biliary Tract, Cyst | |
Biliary Tract, Cyst Multilocular | X X X |
Biliary Tract, Dilatation | |
Biliary Tract, Subserosa, | |
Hyperplasia, Multifocal | |
Serosa, Subserosa, Inflammation, | |
Chronic, Multifocal | 4 1 1 1 1 1 1 2 1|
Serosa, Subserosa, Pigmentation, | |
Multifocal | 1 1 1 1 1 1 1 2 1|
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 2 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 |
Acinus, Atrophy, Multifocal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 |
Inflammation, Subacute | 2 2 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 7| 4| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 6| 6| 7|
DAY ON TEST | 3| 7| 6| 7| 3| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 8| 3| 3| 3| 3| 5| 3| 6| 3|
| 0| 5| 7| 6| 0| 8| 0| 0| 0| 0| 4| 0| 0| 0| 0| 2| 2| 0| 0| 0| 0| 6| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
175 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer, Multiple | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 |
Ulcer | |
__________________________________________________________________________|
Tooth | + + + + + + + + + +|
Dysplasia | 1 3 4 1 4 2 4 4 2 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 4 2 1 1 1 |
Hypertrophy, Focal | 1 |
Capsule, Accessory Adrenal Cortical | |
Nodule | 2 |
Spindle Cell, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 3 2 2|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 |
Follicle, Cyst | |
Follicle, Degeneration, Cystic | 2 1 2 2 2 1 2 2 2|
Follicular Cell, Hyperplasia, Cystic,| |
Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Dilatation | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2|
Pigmentation, Focal, Cholesterol | 2|
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Inflammation, Subacute | 4 4 3 3 4 |
Duct, Cyst | X X X |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 7| 4| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 6| 6| 7|
DAY ON TEST | 3| 7| 6| 7| 3| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 8| 3| 3| 3| 3| 5| 3| 6| 3|
| 0| 5| 7| 6| 0| 8| 0| 0| 0| 0| 4| 0| 0| 0| 0| 2| 2| 0| 0| 0| 0| 6| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
175 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 |
Inflammation, Subacute | 3 |
Necrosis, Focal | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukocytosis | 2 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Lymphoid | 2 2 |
Necrosis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 2 2 2 3 1 4 |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 2 2 2 2 |
Inflammation, Chronic | 2 |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 3 2 3 3 3 3 4 3 4|
Hyperplasia, Lymphoid | 3 2 2 4 2 2 2 3 4 2 2|
Necrosis | |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + M +|
Cyst | |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + + M M M M M + M M M M + M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia, Focal | |
Epidermis, Hyperplasia, Focal | 2 |
Sebaceous Gland, Hyperplasia, Focal | 2 |
Subcutaneous Tissue, Fibrosis, Focal | 2 3 2 2|
Subcutaneous Tissue, Inflammation, | |
Focal, Subacute | 3 4|
Subcutaneous Tissue, Metaplasia, | |
Focal, Osseous | 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 7| 4| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 6| 6| 7|
DAY ON TEST | 3| 7| 6| 7| 3| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 6| 8| 3| 3| 3| 3| 5| 3| 6| 3|
| 0| 5| 7| 6| 0| 8| 0| 0| 0| 0| 4| 0| 0| 0| 0| 2| 2| 0| 0| 0| 0| 6| 2| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
175 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Mineralization, | |
Focal | |
Subcutaneous Tissue, Necrosis, Focal | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arthrosis, Chronic | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Foreign Body | |
Hemorrhage, Multifocal | |
Infiltration Cellular, Multifocal, | |
Histiocyte | 2 3 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Subacute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium, Multifocal | 4 |
Fibrosis, Focal | 2 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 1 2 2 1 1 1 1 2 1 2 1 |
Inflammation, Acute, Multifocal, | |
Suppurative | 4 |
Metaplasia, Focal, Osseous | |
Nephropathy, Chronic | 1 2 1 3 1 3 2 1 1 1 2 1 3 4 1 1 1 2 3 1 2|
Renal Tubule, Mineralization, | |
Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 2| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 4| 5| 7| 7| 0| 0| 0| 0| 0| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 9| 3| 3| 3| 6| 3| 2| 3| 3| 4| 6| 6| 3| 3| 5| 5| 5| 5| 5| 2| 3| 3| 3| 3| |
| 4| 6| 0| 0| 0| 6| 0| 8| 0| 0| 8| 4| 3| 0| 0| 6| 6| 7| 7| 7| 8| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
175 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | A M + + + M + + + M M + M + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + + + + + + + + + + + + + + + + A + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M A + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + A + + A + + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Focal Cellular Change | X X| 5 |
Hematopoietic Cell Proliferation | | 1 2.0|
Inclusion Body Intranuclear | 2| 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 1 1.0|
Mineralization, Focal | | 1 2.0|
Necrosis, Focal | 4 | 2 4.0|
Necrosis, Multifocal | 4 3 1 3 | 8 2.8|
Vacuolization Cytoplasmic, Diffuse | 3 | 1 3.0|
Vacuolization Cytoplasmic, Multifocal| | 1 1.0|
Biliary Tract, Cyst | X | 1 |
Biliary Tract, Cyst Multilocular | | 3 |
Biliary Tract, Dilatation | 2 | 1 2.0|
Biliary Tract, Subserosa, | | |
Hyperplasia, Multifocal | 1 1| 2 1.0|
Serosa, Subserosa, Inflammation, | | |
Chronic, Multifocal | 1 2 1 1 1 1 1 1 2| 18 1.3|
Serosa, Subserosa, Pigmentation, | | |
Multifocal | 1 2 1 1 1 1 1 1 2| 18 1.2|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Fat, Necrosis, Focal | 4 | 4 3.0|
__________________________________________________________________________|____________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Focal | | 1 2.0|
Acinus, Atrophy, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 2 2 1 1 1 1| 24 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 2| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 4| 5| 7| 7| 0| 0| 0| 0| 0| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 9| 3| 3| 3| 6| 3| 2| 3| 3| 4| 6| 6| 3| 3| 5| 5| 5| 5| 5| 2| 3| 3| 3| 3| |
| 4| 6| 0| 0| 0| 6| 0| 8| 0| 0| 8| 4| 3| 0| 0| 6| 6| 7| 7| 7| 8| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
175 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Hyperplasia | 3 2 | 6 2.2|
Inflammation, Subacute | | 2 2.0|
Mineralization | | 1 1.0|
Ulcer, Multiple | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Mineralization | | 3 1.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + +| 19 |
Dysplasia | 4 4 2 1 4 4 1 4 2| 19 2.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 5 1.8|
Hypertrophy, Focal | 1 | 2 1.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 1 2.0|
Spindle Cell, Hyperplasia, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 1 | 6 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 2 3 2 | 12 2.1|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + M M M + + + + + + +| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | X X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X | 2 2.0|
Follicle, Cyst | X X X | 3 |
Follicle, Degeneration, Cystic | 2 2 2 2 2 | 14 1.9|
Follicular Cell, Hyperplasia, Cystic,| | |
Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 2| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 4| 5| 7| 7| 0| 0| 0| 0| 0| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 9| 3| 3| 3| 6| 3| 2| 3| 3| 4| 6| 6| 3| 3| 5| 5| 5| 5| 5| 2| 3| 3| 3| 3| |
| 4| 6| 0| 0| 0| 6| 0| 8| 0| 0| 8| 4| 3| 0| 0| 6| 6| 7| 7| 7| 8| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
175 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 2 |
Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | | 1 2.0|
Pigmentation, Focal, Cholesterol | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 8 |
Inflammation, Subacute | 2 | 6 3.3|
Duct, Cyst | X X | 5 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Inflammation, Subacute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 | 3 2.0|
Inflammation, Subacute | | 1 3.0|
Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Leukocytosis | | 1 2.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 1 1 | 8 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Angiectasis | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 3 | 3 2.3|
Necrosis | 3 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 3 4 | 12 2.6|
Hematopoietic Cell Proliferation | 2 | 3 2.0|
Hyperplasia, Lymphoid | 2 2 2 2 2 2| 10 2.0|
Inflammation, Chronic | | 1 2.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 4 3 | 3 3.3|
Hematopoietic Cell Proliferation | 3 4 3 | 12 3.2|
Hyperplasia, Lymphoid | 3 2 2 2 2| 16 2.4|
Necrosis | 2 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + M + + + + + + + + M + + + + +| 45 |
Cyst | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 2| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 4| 5| 7| 7| 0| 0| 0| 0| 0| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 9| 3| 3| 3| 6| 3| 2| 3| 3| 4| 6| 6| 3| 3| 5| 5| 5| 5| 5| 2| 3| 3| 3| 3| |
| 4| 6| 0| 0| 0| 6| 0| 8| 0| 0| 8| 4| 3| 0| 0| 6| 6| 7| 7| 7| 8| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
175 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Necrosis | 3 4 4 3 | 4 3.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alopecia, Focal | 3 | 1 3.0|
Epidermis, Hyperplasia, Focal | | 1 2.0|
Sebaceous Gland, Hyperplasia, Focal | | 1 2.0|
Subcutaneous Tissue, Fibrosis, Focal | 3 2 2 3 2 4 | 10 2.5|
Subcutaneous Tissue, Inflammation, | | |
Focal, Subacute | 2 | 3 3.0|
Subcutaneous Tissue, Metaplasia, | | |
Focal, Osseous | | 1 2.0|
Subcutaneous Tissue, Mineralization, | | |
Focal | 2 | 1 2.0|
Subcutaneous Tissue, Necrosis, Focal | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Arthrosis, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 2 2.5|
Foreign Body | 3 | 1 3.0|
Hemorrhage, Multifocal | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 2 2 | 6 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Suppurative | 3 3 2 3 | 4 2.8|
Nasolacrimal Duct, Inflammation, | | |
Subacute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 2| 6| 7| 7| 7| 5| 7| 7| 7| 7| 5| 4| 5| 7| 7| 0| 0| 0| 0| 0| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 9| 3| 3| 3| 6| 3| 2| 3| 3| 4| 6| 6| 3| 3| 5| 5| 5| 5| 5| 2| 3| 3| 3| 3| |
| 4| 6| 0| 0| 0| 6| 0| 8| 0| 0| 8| 4| 3| 0| 0| 6| 6| 7| 7| 7| 8| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
175 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium, Multifocal | | 1 4.0|
Fibrosis, Focal | | 2 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2 1 1 2 2 2 1 1 1 | 23 1.3|
Inflammation, Acute, Multifocal, | | |
Suppurative | | 1 4.0|
Metaplasia, Focal, Osseous | 3 | 1 3.0|
Nephropathy, Chronic | 1 1 1 4 1 2 4 4 1 1 1 1 1 2 1| 36 1.8|
Renal Tubule, Mineralization, | | |
Multifocal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 1| 6| 5| 6| 7| 5| 6| 7| 7| 7| 7| 4| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 7| 6| 2| 9| 9| 2| 2| 2| 2| 5| 3| 1| 2| 2| 3| 2| 2| 2| 5| 6| 2| 2| 2|
| 3| 8| 3| 6| 9| 0| 8| 9| 9| 9| 9| 9| 0| 0| 9| 0| 5| 9| 9| 9| 0| 1| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | |
Developmental Malformation | |
Fibrosis, Focal | |
Focal Cellular Change | X X X X |
Focal Cellular Change, Multiple | X |
Granuloma, Multiple | 1 1 |
Hematopoietic Cell Proliferation | 1|
Hepatodiaphragmatic Nodule | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 1 |
Necrosis, Multifocal | 1 1|
Biliary Tract, Cyst | 2 |
Biliary Tract, Subserosa, | |
Hyperplasia, Multifocal | 1 1 1 |
Centrilobular, Vacuolization | |
Cytoplasmic, Diffuse | |
Serosa, Subserosa, Inflammation, | |
Chronic, Multifocal | 1 1 1 2 1 1 1|
Serosa, Subserosa, Pigmentation, | |
Multifocal | 1 1 1 2 1 1 1|
Sinusoid, Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis, Focal | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
Acinus, Atrophy, Multifocal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 1| 6| 5| 6| 7| 5| 6| 7| 7| 7| 7| 4| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 7| 6| 2| 9| 9| 2| 2| 2| 2| 5| 3| 1| 2| 2| 3| 2| 2| 2| 5| 6| 2| 2| 2|
| 3| 8| 3| 6| 9| 0| 8| 9| 9| 9| 9| 9| 0| 0| 9| 0| 5| 9| 9| 9| 0| 1| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Foreign Body | |
Hyperplasia | 2 2 2 |
Inflammation, Subacute | 2 2 |
Ulcer | |
Ulcer, Multiple | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Mineralization | 1 1 |
__________________________________________________________________________|
Tooth | + + + + + + + + + |
Dysplasia | 1 3 4 4 3 4 4 2 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Subacute | |
Atrium, Thrombosis | |
Pericardium, Fibrosis | |
Pericardium, Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 2 |
Hypertrophy, Focal | 2 |
Capsule, Accessory Adrenal Cortical | |
Nodule | X |
Spindle Cell, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Focal | 2 2 2 1 4|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 1 2 1 3 2 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 2 |
Pars Nervosa, Fibrosis | 3 |
__________________________________________________________________________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
Follicle, Cyst | |
Follicle, Degeneration, Cystic | 2 3 1 1 1 1 |
Follicular Cell, Hyperplasia, Cystic,| |
Focal | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 1| 6| 5| 6| 7| 5| 6| 7| 7| 7| 7| 4| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 7| 6| 2| 9| 9| 2| 2| 2| 2| 5| 3| 1| 2| 2| 3| 2| 2| 2| 5| 6| 2| 2| 2|
| 3| 8| 3| 6| 9| 0| 8| 9| 9| 9| 9| 9| 0| 0| 9| 0| 5| 9| 9| 9| 0| 1| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
Dilatation | 3 3 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
Inflammation, Subacute | 4 4 2 3 3 |
Duct, Cyst | X X X X X X |
Duct, Hyperplasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + M + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 3 2 2 3 |
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukocytosis | 3 |
Polychromasia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Iliac, Hyperplasia, Lymphoid | 3 |
Inguinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 3 2 2 4 2|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 3 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Hematopoietic Cell Proliferation | 4 4 4 2 2 4 3 3|
Hyperplasia, Lymphoid | 4 3 2 2 3 4 2 4 |
__________________________________________________________________________|
Thymus | M + + M + + + + + + + + + + + + + + + + M + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 1| 6| 5| 6| 7| 5| 6| 7| 7| 7| 7| 4| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 7| 6| 2| 9| 9| 2| 2| 2| 2| 5| 3| 1| 2| 2| 3| 2| 2| 2| 5| 6| 2| 2| 2|
| 3| 8| 3| 6| 9| 0| 8| 9| 9| 9| 9| 9| 0| 0| 9| 0| 5| 9| 9| 9| 0| 1| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cyst | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + + M M M M M + M M M M M M M M M M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia, Focal | 2 2 |
Fibrosis, Multifocal | 2 |
Ulcer, Focal | |
Epidermis, Hyperplasia, Focal | 2 2 2 2 2 |
Epidermis, Inflammation, Acute, | |
Focal, Suppurative | 2 |
Sebaceous Gland, Hyperplasia, Focal | 2 |
Subcutaneous Tissue, Edema, Focal | 2 |
Subcutaneous Tissue, Fibrosis, Focal | 3 2 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Arthrosis, Chronic | 4 |
Fracture | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 2 |
Edema, Focal | 2 |
Hemorrhage | |
Hydrocephalus | 2 |
Meninges, Infiltration Cellular, | |
Multifocal, Lymphocyte | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Multifocal, | |
Histiocyte | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
Mediastinum, Inflammation, Focal, | |
Subacute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Cyst | 2 |
Nasolacrimal Duct, Exudate | 2 |
Nasolacrimal Duct, Inflammation, | |
Subacute | 2 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 1| 6| 5| 6| 7| 5| 6| 7| 7| 7| 7| 4| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 7| 6| 2| 9| 9| 2| 2| 2| 2| 5| 3| 1| 2| 2| 3| 2| 2| 2| 5| 6| 2| 2| 2|
| 3| 8| 3| 6| 9| 0| 8| 9| 9| 9| 9| 9| 0| 0| 9| 0| 5| 9| 9| 9| 0| 1| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 1 1 2 1 1 2 2 1 1 1|
Nephropathy, Chronic | 1 1 2 1 2 2 1 2 1 1 2 1 1 1 2 2 2 1|
Renal Tubule, Dilatation, Multifocal | 2 |
Renal Tubule, Necrosis, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 5| 6| 7| 7| 7| 4| 6| 6| 7| 7| 4| 4| 6| 7| 7| |
DAY ON TEST | 2| 1| 1| 2| 2| 2| 0| 7| 2| 2| 9| 8| 2| 2| 2| 0| 8| 4| 1| 2| 0| 0| 2| 2| 2| |
| 9| 7| 4| 9| 9| 9| 4| 1| 9| 9| 9| 8| 9| 9| 9| 5| 8| 8| 3| 9| 1| 3| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
100 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + M M + + + + + + + + + M + M M| 43 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Perforation | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis, Focal | 2 | 1 2.0|
Basophilic Focus | 2 | 1 2.0|
Developmental Malformation | 2 | 1 2.0|
Fibrosis, Focal | 1 | 1 1.0|
Focal Cellular Change | | 4 |
Focal Cellular Change, Multiple | | 1 |
Granuloma, Multiple | | 2 1.0|
Hematopoietic Cell Proliferation | 3 | 2 2.0|
Hepatodiaphragmatic Nodule | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 4 1.0|
Necrosis, Multifocal | 3 3 2 2 2 | 7 2.0|
Biliary Tract, Cyst | | 1 2.0|
Biliary Tract, Subserosa, | | |
Hyperplasia, Multifocal | | 3 1.0|
Centrilobular, Vacuolization | | |
Cytoplasmic, Diffuse | 2 | 1 2.0|
Serosa, Subserosa, Inflammation, | | |
Chronic, Multifocal | 2 | 8 1.3|
Serosa, Subserosa, Pigmentation, | | |
Multifocal | 2 | 8 1.3|
Sinusoid, Infiltration Cellular, | | |
Polymorphonuclear | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Fat, Necrosis, Focal | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Multifocal, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 5| 6| 7| 7| 7| 4| 6| 6| 7| 7| 4| 4| 6| 7| 7| |
DAY ON TEST | 2| 1| 1| 2| 2| 2| 0| 7| 2| 2| 9| 8| 2| 2| 2| 0| 8| 4| 1| 2| 0| 0| 2| 2| 2| |
| 9| 7| 4| 9| 9| 9| 4| 1| 9| 9| 9| 8| 9| 9| 9| 5| 8| 8| 3| 9| 1| 3| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
100 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Lymphocyte | | 1 1.0|
Acinus, Atrophy, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 1 1 1 1 1 1 | 21 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 2 | 1 2.0|
Foreign Body | 2 | 1 2.0|
Hyperplasia | 2 2 3 1 2 | 8 2.0|
Inflammation, Subacute | 2 | 3 2.0|
Ulcer | 2 | 1 2.0|
Ulcer, Multiple | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Subacute | | 1 2.0|
Mineralization | | 2 1.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + | 15 |
Dysplasia | 4 4 3 4 4 2 | 15 3.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Focal, Subacute | 2 2 3 2 | 4 2.3|
Atrium, Thrombosis | 4 | 1 4.0|
Pericardium, Fibrosis | 3 | 1 3.0|
Pericardium, Inflammation, Subacute | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | | 3 1.7|
Hypertrophy, Focal | 2 2 | 3 2.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 1 |
Spindle Cell, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Focal | 1 2 | 7 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 2 2 2 | 15 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 5| 6| 7| 7| 7| 4| 6| 6| 7| 7| 4| 4| 6| 7| 7| |
DAY ON TEST | 2| 1| 1| 2| 2| 2| 0| 7| 2| 2| 9| 8| 2| 2| 2| 0| 8| 4| 1| 2| 0| 0| 2| 2| 2| |
| 9| 7| 4| 9| 9| 9| 4| 1| 9| 9| 9| 8| 9| 9| 9| 5| 8| 8| 3| 9| 1| 3| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
100 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + M + + + + + + + + + + + + + +| 46 |
Pars Distalis, Hyperplasia, Focal | | 2 2.0|
Pars Nervosa, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ultimobranchial Cyst | 2 | 1 2.0|
Follicle, Cyst | X X | 2 |
Follicle, Degeneration, Cystic | 2 2 1 2 1 3 1 1 | 14 1.6|
Follicular Cell, Hyperplasia, Cystic,| | |
Focal | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 2 |
Dilatation | | 2 3.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 3 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + +| 14 |
Inflammation, Subacute | 3 4 2 2 2 2 3| 12 2.8|
Duct, Cyst | X X X X X X| 12 |
Duct, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
Dilatation | | 6 2.7|
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + | 4 |
Leukocytosis | 3 2 | 3 2.7|
Polychromasia | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 5| 6| 7| 7| 7| 4| 6| 6| 7| 7| 4| 4| 6| 7| 7| |
DAY ON TEST | 2| 1| 1| 2| 2| 2| 0| 7| 2| 2| 9| 8| 2| 2| 2| 0| 8| 4| 1| 2| 0| 0| 2| 2| 2| |
| 9| 7| 4| 9| 9| 9| 4| 1| 9| 9| 9| 8| 9| 9| 9| 5| 8| 8| 3| 9| 1| 3| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
100 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia | 2 1 4 2 2 2 | 10 2.4|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | | 1 2.0|
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | 4 | 2 3.5|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 2 2 2 2 2 2 2 2 | 17 2.2|
Hematopoietic Cell Proliferation | 1 2 | 3 1.7|
Hyperplasia, Lymphoid | 2 3 3 2| 7 2.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Developmental Malformation | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 4 4 3 4 2 2 4 4 4 4 | 18 3.4|
Hyperplasia, Lymphoid | 2 2 3 2 3| 13 2.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + M + +| 44 |
Atrophy | 2 | 1 2.0|
Cyst | X X X X X | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + M M M M + + M M M M M M + M M + M M M M M| 9 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alopecia, Focal | 2 | 3 2.0|
Fibrosis, Multifocal | | 1 2.0|
Ulcer, Focal | 2 3 | 2 2.5|
Epidermis, Hyperplasia, Focal | 2 2 2 | 8 2.0|
Epidermis, Inflammation, Acute, | | |
Focal, Suppurative | 3 | 2 2.5|
Sebaceous Gland, Hyperplasia, Focal | | 1 2.0|
Subcutaneous Tissue, Edema, Focal | | 1 2.0|
Subcutaneous Tissue, Fibrosis, Focal | 3 2 2 2 | 8 2.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Arthrosis, Chronic | 2 | 2 3.0|
Fracture | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 5| 6| 7| 7| 7| 4| 6| 6| 7| 7| 4| 4| 6| 7| 7| |
DAY ON TEST | 2| 1| 1| 2| 2| 2| 0| 7| 2| 2| 9| 8| 2| 2| 2| 0| 8| 4| 1| 2| 0| 0| 2| 2| 2| |
| 9| 7| 4| 9| 9| 9| 4| 1| 9| 9| 9| 8| 9| 9| 9| 5| 8| 8| 3| 9| 1| 3| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
100 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Focal | | 1 2.0|
Edema, Focal | | 1 2.0|
Hemorrhage | 3 | 1 3.0|
Hydrocephalus | | 1 2.0|
Meninges, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 2 2 3 | 4 2.3|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 1.0|
Mediastinum, Inflammation, Focal, | | |
Subacute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Nasolacrimal Duct, Cyst | | 1 2.0|
Nasolacrimal Duct, Exudate | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis, Focal | 1 2 | 3 1.7|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 1 1 1 1 1 2 1 1 1 1 | 25 1.2|
Nephropathy, Chronic | 3 1 1 1 2 1 3 2 2 2 1 1 2 1 1 1 1 1 1| 37 1.5|
Renal Tubule, Dilatation, Multifocal | | 1 2.0|
Renal Tubule, Necrosis, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 5| 6| 7| 7| 7| 2| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 0| 7| 3| 3| 9| 6| 3| 3| 3| 0| 8| 9| 3| 3| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 2| 9| 3| 2| 2| 5| 8| 2| 2| 2| 5| 8| 7| 2| 2| 7| 2| 2| 2| 2| 3| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Acute, Suppurative | |
__________________________________________________________________________|
Gallbladder | + + + + + + M + + + M + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + M + + + +|
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | M + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus Tumor | |
Focal Cellular Change | X X X X X |
Hematopoietic Cell Proliferation | 2 3 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
Mineralization, Focal | |
Necrosis, Multifocal | 2 |
Pigmentation, Hematoidin | |
Vacuolization Cytoplasmic, Focal | 2 |
Biliary Tract, Dilatation | 2 |
Biliary Tract, Proliferation | 2 |
Kupffer Cell, Pigmentation, | |
Multifocal | 3 3 |
Sinusoid, Infiltration Cellular, | |
Polymorphonuclear | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Multifocal | |
Acinus, Atrophy, Multifocal | 2 |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 1 1 1 1 2 1 1 1 2 |
Inflammation, Acute, Focal, | |
Suppurative | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 5| 6| 7| 7| 7| 2| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 0| 7| 3| 3| 9| 6| 3| 3| 3| 0| 8| 9| 3| 3| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 2| 9| 3| 2| 2| 5| 8| 2| 2| 2| 5| 8| 7| 2| 2| 7| 2| 2| 2| 2| 3| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Subacute | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Multiple | 1 |
Inflammation, Subacute | 2 |
Mineralization | |
__________________________________________________________________________|
Tooth | + + + + + + + + + |
Dysplasia | 4 4 4 4 4 4 4 4 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Inflammation, Focal, Subacute | |
Inflammation, Multifocal, Subacute | 2 |
Endothelium, Hyperplasia | |
Valve, Bacterium | |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hypertrophy, Focal | 2 |
Capsule, Accessory Adrenal Cortical | |
Nodule | X |
Spindle Cell, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + M + + + M + + + + + + M + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicle, Degeneration, Cystic | 2 2 2 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + |
Dilatation | 3 3 2 |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 5| 6| 7| 7| 7| 2| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 0| 7| 3| 3| 9| 6| 3| 3| 3| 0| 8| 9| 3| 3| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 2| 9| 3| 2| 2| 5| 8| 2| 2| 2| 5| 8| 7| 2| 2| 7| 2| 2| 2| 2| 3| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + |
Hyperplasia | |
Inflammation, Subacute | 3 4 3 4 4 3 |
Duct, Cyst | X X X X X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Dilatation | 3 3 3 2 3 |
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Leukocytosis | 3 2 |
Polychromasia | 2 2 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 1 |
Necrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid | 4 |
Inguinal, Hyperplasia, Lymphoid | 4 3 3 |
Inguinal, Inflammation, Subacute | 2 |
Renal, Angiectasis | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + M + + + M + + + + + + +|
Ectasia | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 2 4 2 2 2 2 4 |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 2 2 3 4|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 2 3 3 2 3 4 3 3 4 4 3 3 |
Hyperplasia, Lymphoid | 3 3 2 2 3 3 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + M + + + M M + + M M +|
Atrophy | 2 2 3 |
Cyst | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 5| 6| 7| 7| 7| 2| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 0| 7| 3| 3| 9| 6| 3| 3| 3| 0| 8| 9| 3| 3| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 2| 9| 3| 2| 2| 5| 8| 2| 2| 2| 5| 8| 7| 2| 2| 7| 2| 2| 2| 2| 3| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperplasia, Focal | 2 2 2 |
Prepuce, Developmental Malformation | 2 |
Sebaceous Gland, Hyperplasia, Focal | |
Subcutaneous Tissue, Cyst | X|
Subcutaneous Tissue, Fibrosis, Focal | 2 2 |
Subcutaneous Tissue, Inflammation, | |
Acute, Focal, Suppurative | |
Subcutaneous Tissue, Inflammation, | |
Focal, Subacute | 2 2 |
Subcutaneous Tissue, Metaplasia, | |
Focal, Osseous | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + M + + + + + + + + + + + + + +|
Arthrosis, Chronic | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | |
Infiltration Cellular, Multifocal, | |
Histiocyte | 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
Mediastinum, Foreign Body | |
Mediastinum, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Subacute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 7| 5| 6| 7| 7| 7| 2| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 0| 7| 3| 3| 9| 6| 3| 3| 3| 0| 8| 9| 3| 3| 4| 3| 3| 3| 3| 6| 3| 3| 3| 3|
| 2| 9| 3| 2| 2| 5| 8| 2| 2| 2| 5| 8| 7| 2| 2| 7| 2| 2| 2| 2| 3| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
50 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Fibrosis, Focal | 2 2|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 1 1 2 2 2 2 2 |
Inflammation, Acute, Multifocal, | |
Suppurative | |
Metaplasia, Focal, Osseous | |
Nephropathy, Chronic | 1 2 1 2 1 3 1 1 2 2 1 2 1 1 1 1 2 1 2 2 1|
Renal Tubule, Hyperplasia | |
Renal Tubule, Necrosis, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 0| 4| 6| 7| 7| 7| 5| 6| 6| 7| 5| 5| 6| 7| 7| 0| 4| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 7| 1| 3| 3| 7| 5| 8| 3| 0| 7| 9| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 3| 5| 1| 2| 5| 3| 2| 2| 5| 6| 9| 3| 5| 5| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
50 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + I + + + + + + + + +| 49 |
Foreign Body | 4 | 1 4.0|
Inflammation, Acute, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Gallbladder | M A + + + + + + M + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +| 47 |
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + M + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + A + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + A + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Embolus Tumor | X | 1 |
Focal Cellular Change | X X | 7 |
Hematopoietic Cell Proliferation | | 2 2.5|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 2 1.0|
Mineralization, Focal | 1 | 1 1.0|
Necrosis, Multifocal | 3 | 2 2.5|
Pigmentation, Hematoidin | 1 | 1 1.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Biliary Tract, Dilatation | | 1 2.0|
Biliary Tract, Proliferation | | 1 2.0|
Kupffer Cell, Pigmentation, | | |
Multifocal | | 2 3.0|
Sinusoid, Infiltration Cellular, | | |
Polymorphonuclear | 1 | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis, Focal | 2 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis, Multifocal | 2 | 1 2.0|
Acinus, Atrophy, Multifocal | 1 1 4 | 4 2.0|
Duct, Cyst | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 1 1 2 2 1 2 1| 21 1.2|
Inflammation, Acute, Focal, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 0| 4| 6| 7| 7| 7| 5| 6| 6| 7| 5| 5| 6| 7| 7| 0| 4| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 7| 1| 3| 3| 7| 5| 8| 3| 0| 7| 9| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 3| 5| 1| 2| 5| 3| 2| 2| 5| 6| 9| 3| 5| 5| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
50 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Erosion | | 1 2.0|
Hyperplasia | 3 2 | 2 2.5|
Inflammation, Subacute | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Erosion, Multiple | | 1 1.0|
Inflammation, Subacute | | 1 2.0|
Mineralization | 2 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + +| 21 |
Dysplasia | 4 4 4 3 4 3 4 4 4 4 4| 20 3.9|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 4 | 1 4.0|
Inflammation, Focal, Subacute | 2 | 1 2.0|
Inflammation, Multifocal, Subacute | | 1 2.0|
Endothelium, Hyperplasia | 3 | 1 3.0|
Valve, Bacterium | 3 | 1 3.0|
Valve, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 2 2 2 | 4 1.8|
Hypertrophy, Focal | 1 | 2 1.5|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 1 |
Spindle Cell, Hyperplasia, Focal | 2 | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
Hyperplasia | 2 2 2 1 1 1 2 2 2 2 1 | 21 1.7|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + M + + M + + + + + + + + +| 43 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | M M + + + + + + + + + + + + + I + + + + + + + + +| 45 |
Pars Distalis, Cyst | X X | 2 |
Pars Distalis, Hyperplasia, Focal | 3 1 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 0| 4| 6| 7| 7| 7| 5| 6| 6| 7| 5| 5| 6| 7| 7| 0| 4| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 7| 1| 3| 3| 7| 5| 8| 3| 0| 7| 9| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 3| 5| 1| 2| 5| 3| 2| 2| 5| 6| 9| 3| 5| 5| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
50 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Cyst | X | 1 |
Follicle, Degeneration, Cystic | 2 3 2 1 2 1 2 | 15 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + | 5 |
Dilatation | 4 3 | 5 3.0|
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 10 |
Hyperplasia | 3 | 1 3.0|
Inflammation, Subacute | 3 3 | 8 3.4|
Duct, Cyst | X X | 8 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 2 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Dilatation | 2 3 | 7 2.7|
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
Leukocytosis | | 2 2.5|
Polychromasia | | 2 2.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 | 7 1.4|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Hyperplasia, Lymphoid | | 1 4.0|
Inguinal, Hyperplasia, Lymphoid | 3 | 4 3.3|
Inguinal, Inflammation, Subacute | | 1 2.0|
Renal, Angiectasis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 0| 4| 6| 7| 7| 7| 5| 6| 6| 7| 5| 5| 6| 7| 7| 0| 4| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 7| 1| 3| 3| 7| 5| 8| 3| 0| 7| 9| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 3| 5| 1| 2| 5| 3| 2| 2| 5| 6| 9| 3| 5| 5| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
50 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + + + + +| 46 |
Ectasia | 4 | 1 4.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + A + + M + + + + M + + A + + + + + + + + + + + +| 45 |
Angiectasis | 2 1 4 2 2 2 2 2 2 | 18 2.4|
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia, Lymphoid | 2 3 2 2| 8 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 2 2.5|
Hematopoietic Cell Proliferation | 2 4 2 3 4 2 4 | 19 3.1|
Hyperplasia, Lymphoid | 2 3 2 2 3 2 2| 14 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + M + + + + + + + +| 42 |
Atrophy | 4 2 2 2 | 7 2.4|
Cyst | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M + M M M M M M M M M M M M M M + M M M M| 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Hyperplasia, Focal | 2 2 | 5 2.0|
Prepuce, Developmental Malformation | 2 | 2 2.0|
Sebaceous Gland, Hyperplasia, Focal | 3 | 1 3.0|
Subcutaneous Tissue, Cyst | X | 2 |
Subcutaneous Tissue, Fibrosis, Focal | 2 1 3 | 5 2.0|
Subcutaneous Tissue, Inflammation, | | |
Acute, Focal, Suppurative | 4 | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Focal, Subacute | 2 | 3 2.0|
Subcutaneous Tissue, Metaplasia, | | |
Focal, Osseous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Arthrosis, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05005-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:04:55
__________________________________________________________________________________________________________________________________
| 0| 4| 6| 7| 7| 7| 5| 6| 6| 7| 5| 5| 6| 7| 7| 0| 4| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 6| 3| 7| 1| 3| 3| 7| 5| 8| 3| 0| 7| 9| 3| 3| 1| 9| 3| 3| 3| 3| 3| 3| 3| 3| |
| 0| 3| 5| 1| 2| 5| 3| 2| 2| 5| 6| 9| 3| 5| 5| 1| 1| 5| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
50 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MG/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 4 | 1 4.0|
Foreign Body | 3 | 1 3.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 2 2 2 | 4 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 3 | 1 3.0|
Mediastinum, Foreign Body | 4 3 | 2 3.5|
Mediastinum, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Suppurative | 1 | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | 2 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 2 2 | 4 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 2 1 1 1 1 1 1 1 | 19 1.4|
Inflammation, Acute, Multifocal, | | |
Suppurative | 2 | 1 2.0|
Metaplasia, Focal, Osseous | 2 | 1 2.0|
Nephropathy, Chronic | 3 1 4 1 1 1 1 1 1 1 1 2 2 1 2 1 1 1| 39 1.5|
Renal Tubule, Hyperplasia | 2 | 1 2.0|
Renal Tubule, Necrosis, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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