TR 382 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/03/94
EXP: 05005 FURFURAL TIME: 06:59:34
TEST: 08 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56177
CONT: NO1CP9565101 CAS: 98-01-1
PATHOLOGIST: H. GILES S. EUSTIS
--------------------------------------------------------------------------------
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/03/94
EXP: 05005 FURFURAL TIME: 06:59:34
TEST: 08 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56177
CONT: NO1CP9565101 CAS: 98-01-1
PATHOLOGIST: H. GILES S. EUSTIS
FURFURAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 2 121 375 456 456 473 518 580 611 622 |
| 662 666 676 703 719 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 2 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 205 433 491 492 506 563 573 579 595 609 |
| 647 652 668 673 675 682 688 693 697 711 |
| CENSORED DEATHS |
| 11 60 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 1 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 123 401 403 405 459 504 571 573 590 599 |
| 617 620 629 630 635 638 648 650 666 688 |
| 688 698 710 713 714 |
| CENSORED DEATHS |
| 661 |
| |
==================================================================================
FURFURAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 175. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 6 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 456 464 467 475 548 563 566 576 632 662 |
| 662 682 688 696 724 728 728 |
| CENSORED DEATHS |
| 56 56 57 57 57 224 |
| |
==================================================================================
FURFURAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 98.0 96.0 96.0 96.0 94.0 88.0 86.0 84.0 78.0 70.0 |
|CONTROL | |
| | |
|50. | 100.0 100.0 97.9 97.9 97.9 95.8 89.6 81.3 75.0 58.3 |
|MG/KG | |
| | |
|100. | 100.0 98.0 98.0 98.0 92.0 90.0 88.0 80.0 64.0 49.5 |
|MG/KG | |
| | |
|175. | 100.0 100.0 100.0 100.0 100.0 90.9 90.9 81.8 75.0 61.4 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 50. 100. 175. |
| CONTROL MG/KG MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 70.0% 58.3% 49.5% 61.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.469 P=0.373 P=0.079 P=0.605 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 509.3 591.6 582.9 606.9 |
|NATURAL DEATHS (C) | (54.3) (27.3) (27.2) (24.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 663.1 646.3 654.6 610.1 |
|(STANDARD ERROR) | (21.4) (22.9) (17.0) (30.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
FURFURAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 1 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 405 456 473 491 492 543 576 598 620 630 |
| 644 648 648 662 671 700 |
| CENSORED DEATHS |
| 11 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 2 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 309 434 435 445 464 473 477 491 492 616 |
| 630 634 654 657 679 693 704 710 715 719 |
| CENSORED DEATHS |
| 261 374 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 360 394 438 488 490 493 506 514 523 536 |
| 568 574 575 605 611 648 662 675 693 717 |
| 719 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FURFURAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 175. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 246 382 442 514 526 549 586 596 601 615 |
| 615 633 634 643 654 654 662 670 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
FURFURAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 98.0 93.9 87.8 83.7 71.4 67.3 |
|CONTROL | |
| | |
|50. | 100.0 100.0 100.0 98.0 98.0 85.5 81.3 81.3 70.9 58.4 |
|MG/KG | |
| | |
|100. | 100.0 100.0 100.0 98.0 96.0 94.0 80.0 72.0 66.0 58.0 |
|MG/KG | |
| | |
|175. | 100.0 100.0 98.0 98.0 96.0 94.0 90.0 82.0 66.0 64.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 50. 100. 175. |
| CONTROL MG/KG MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 67.3% 58.4% 58.0% 64.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.839 P=0.486 P=0.401 P=0.842 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 578.6 571.6 561.4 567.9 |
|NATURAL DEATHS (C) | (22.5) (27.8) (22.3) (26.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 666.5 649.6 658.6 671.0 |
|(STANDARD ERROR) | (18.1) (18.3) (15.0) (14.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
FURFURAL
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
50. MG/KG = 2
100. MG/KG = 3
175. MG/KG = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 11 3 2 4
|
| 1 1 2 3 2 44
| 1 1 2 2
95 +
| 1 144
| 3 3
| 4 2 2 4
90 + 1 1 32 2
| 4 4
| 1 3 1 22
| 1 1
P 85 + 22
E | 431 2 1
R | 33 11
C | 4 2 2 4
E 80 + 3 1 4 1
N | 2 2
T | 22 11
| 33 11
S 75 + 2 42 4
U | 1 1
R | 33 2244 1 1
V |
I 70 + 33 44 1 1
V | 22 4 4
A | 33
L | 22
65 +
| 3 3
| 3 22
| 4 4
60 + 2 2
| 2 2
| 33
| 3 3
55 +
|
|
|
50 + 3 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 12 obs hidden.
FURFURAL
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
50. MG/KG = 2
100. MG/KG = 3
175. MG/KG = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 3 1
|
| 4 2 3 4 31 2 1
| 4 3 224 1 1
95 +
| 22 1 31 4
| 4 4
| 2 2
90 + 22 31 4 14
|
P | 22 3 3 14 14
E | 33 14 1
R 85 + 2 2
C | 3 3 1 1
E | 3 3 4 4
N | 2 211
T 80 + 3 3 1 1
| 2 2
S | 4 2211
U | 33
R 75 + 2 2
V | 3 3 441 1
I | 33 4 4
V | 2 112
A 70 + 3 3 1 1
L | 2 2
| 34 3 1 1
| 343 2 2
65 + 22
| 43 3 4
| 3 22
|
60 +
| 2 2
| 3 3
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 12 obs hidden.
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