TR 382 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
FURFURAL
NTP Experiment-Test: 05005-07 Report: PEIRPT03
Study Type: CHRONIC Date: 09/03/94
Route: GAVAGE Time: 04:58:00
Facility: Southern Research Institute
Chemical CAS #: 98-01-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 9 5 4
Moribund 9 11 9
Dosing Accident 4 2 19
Survivors
Dead 1
Terminal Sacrifice 28 32 17
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (50) (48)
Parasite Metazoan 1 (2%) 1 (2%)
Intestine Large, Colon (49) (50) (49)
Cyst 1 (2%)
Parasite Metazoan 4 (8%) 2 (4%) 2 (4%)
Intestine Large, Rectum (50) (50) (47)
Parasite Metazoan 3 (6%) 7 (14%) 3 (6%)
Liver (50) (50) (50)
Angiectasis, Focal 2 (4%) 2 (4%)
Basophilic Focus 39 (78%) 45 (90%) 40 (80%)
Clear Cell Focus 8 (16%) 10 (20%) 14 (28%)
Degeneration, Cystic 1 (2%)
Eosinophilic Focus 1 (2%)
Fatty Change 1 (2%)
Fatty Change, Diffuse 2 (4%) 1 (2%)
Fatty Change, Focal 1 (2%)
Granuloma, Multiple 11 (22%) 22 (44%) 13 (26%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%)
Hepatodiaphragmatic Nodule 3 (6%) 4 (8%) 5 (10%)
Hyperplasia, Focal 2 (4%) 1 (2%) 2 (4%)
Mixed Cell Focus 2 (4%)
Necrosis, Focal 2 (4%) 1 (2%)
Necrosis, Multifocal 1 (2%) 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Bile Duct, Hyperplasia 34 (68%) 28 (56%) 24 (48%)
Centrilobular, Fatty Change 2 (4%) 1 (2%)
Centrilobular, Necrosis 10 (20%) 9 (18%) 4 (8%)
Hepatocyte, Cytomegaly 1 (2%)
Mesentery (8) (10) (11)
Hemorrhage 1 (9%)
Fat, Necrosis, Focal 6 (75%) 10 (100%) 6 (55%)
Pancreas (50) (50) (48)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Atrophy, Focal 2 (4%) 5 (10%)
Acinus, Atrophy, Multifocal 9 (18%) 6 (12%) 4 (8%)
Acinus, Basophilic Focus 1 (2%)
Acinus, Hyperplasia, Focal 2 (4%) 1 (2%)
Acinus, Hyperplasia, Multifocal 1 (2%)
Duct, Ectasia 1 (2%)
Salivary Glands (50) (50) (49)
Atrophy, Multifocal 1 (2%)
Inflammation, Subacute 1 (2%) 1 (2%)
Stomach, Forestomach (50) (50) (50)
Erosion 1 (2%)
Hyperkeratosis 1 (2%)
Hyperplasia 2 (4%) 4 (8%) 3 (6%)
Inflammation, Subacute 2 (4%) 3 (6%) 2 (4%)
Mineralization 1 (2%)
Ulcer 2 (4%) 4 (8%)
Stomach, Glandular (50) (50) (50)
Erosion 1 (2%) 1 (2%)
Erosion, Multiple 1 (2%)
Inflammation, Subacute 1 (2%) 1 (2%) 1 (2%)
Mineralization 9 (18%) 9 (18%) 5 (10%)
Ulcer 1 (2%) 1 (2%) 1 (2%)
Tongue (2)
Foreign Body 1 (50%)
Granuloma 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Mineralization 1 (100%)
Heart (50) (50) (50)
Cardiomyopathy 16 (32%) 24 (48%) 18 (36%)
Inflammation, Chronic, Multifocal 1 (2%)
Mineralization, Multifocal 1 (2%)
Valve, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (50) (50)
Focal Cellular Change 7 (14%) 9 (18%) 5 (10%)
Hematopoietic Cell Proliferation 3 (6%)
Hyperplasia 1 (2%)
Hyperplasia, Focal 2 (4%)
Hypertrophy, Focal 1 (2%)
Inflammation, Granulomatous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Mineralization, Multifocal 1 (2%)
Necrosis, Multifocal 1 (2%)
Capsule, Accessory Adrenal Cortical Nodule 1 (2%) 5 (10%) 2 (4%)
Adrenal Gland, Medulla (47) (50) (50)
Hyperplasia, Focal 4 (9%) 5 (10%) 7 (14%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Islets, Pancreatic (50) (50) (48)
Hyperplasia 2 (4%)
Hyperplasia, Focal 1 (2%)
Parathyroid Gland (48) (48) (48)
Hyperplasia 1 (2%)
Pituitary Gland (49) (50) (50)
Hyperplasia, Focal 1 (2%)
Pars Distalis, Angiectasis 27 (55%) 30 (60%) 19 (38%)
Pars Distalis, Cyst 24 (49%) 16 (32%) 22 (44%)
Pars Distalis, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 12 (24%) 10 (20%) 17 (34%)
Pars Distalis, Pigmentation, Hemosiderin 18 (37%) 22 (44%) 7 (14%)
Thyroid Gland (50) (50) (50)
Ultimobranchial Cyst 1 (2%) 1 (2%) 1 (2%)
C-Cell, Hyperplasia, Focal 11 (22%) 15 (30%) 11 (22%)
Follicle, Cyst 1 (2%) 3 (6%) 1 (2%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (49) (47)
Inflammation, Acute, Suppurative 2 (4%) 2 (4%)
Inflammation, Subacute 1 (2%) 3 (6%) 1 (2%)
Duct, Cyst 3 (6%) 5 (10%) 1 (2%)
Duct, Cyst, Multiple 1 (2%)
Ovary (50) (50) (50)
Cyst 7 (14%) 8 (16%) 7 (14%)
Inflammation, Chronic 1 (2%)
Inflammation, Granulomatous 1 (2%)
Uterus (50) (50) (49)
Cyst 1 (2%) 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%) 2 (4%)
Hydrometra 1 (2%) 1 (2%)
Hyperplasia, Cystic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Neovascularization 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Prolapse 1 (2%)
Cervix, Abscess 1 (2%) 1 (2%)
Cervix, Cyst 1 (2%) 1 (2%)
Cervix, Hypertrophy 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (2)
Anemia 1 (50%)
Polychromasia 1 (50%)
Bone Marrow (50) (47) (50)
Hyperplasia 3 (6%) 6 (13%) 2 (4%)
Lymph Node, Mandibular (50) (50) (49)
Ectasia 3 (6%) 3 (6%) 2 (4%)
Spleen (50) (50) (50)
Atrophy 4 (8%)
Fibrosis, Focal 1 (2%)
Hematopoietic Cell Proliferation 4 (8%) 6 (12%) 4 (8%)
Hemorrhage, Focal 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (50)
Galactocele 1 (2%) 1 (2%)
Duct, Cyst 44 (90%) 39 (78%) 29 (58%)
Duct, Inflammation, Acute, Suppurative 1 (2%)
Skin (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Focal, Subacute 1 (2%)
Subcutaneous Tissue, Abscess 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Fibrous Osteodystrophy 1 (2%)
Cranium, Osteopetrosis 1 (2%) 2 (4%) 2 (4%)
Femur, Osteopetrosis 3 (6%) 3 (6%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49)
Compression 7 (14%) 8 (16%) 3 (6%)
Hemorrhage, Multifocal 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Congestion 6 (12%) 6 (12%) 23 (46%)
Foreign Body 5 (10%) 4 (8%) 19 (38%)
Granuloma, Multiple 16 (32%) 15 (30%) 5 (10%)
Hemorrhage, Multifocal 1 (2%)
Infiltration Cellular, Multifocal, Histiocyte 6 (12%) 6 (12%) 1 (2%)
Mineralization 1 (2%)
Pigmentation, Multifocal, Cholesterol 4 (8%) 2 (4%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%)
Nose (50) (50) (50)
Fungus 1 (2%)
Inflammation, Acute, Suppurative 2 (4%)
Nasolacrimal Duct, Cyst 1 (2%)
Nasolacrimal Duct, Foreign Body 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Acute,
Suppurative 2 (4%) 2 (4%)
Nasolacrimal Duct, Inflammation, Subacute 8 (16%) 12 (24%) 6 (12%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (4) (2)
Cataract 2 (67%) 4 (100%) 2 (100%)
Hemorrhage 1 (33%)
Retina, Degeneration 2 (67%) 4 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Hydronephrosis 1 (2%)
Nephropathy, Chronic 28 (56%) 39 (78%) 29 (58%)
Cortex, Cyst 1 (2%) 1 (2%)
Medulla, Inflammation, Acute, Suppurative 1 (2%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Dilatation, Multifocal 1 (2%)
Renal Tubule, Mineralization, Focal 1 (2%)
Renal Tubule, Mineralization, Multifocal 1 (2%) 1 (2%)
Urinary Bladder (49) (50) (48)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Acute, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dosing Accident 6 7 8
Moribund 11 11 11
Dead 2 4 7
Survivors
Terminal Sacrifice 31 28 24
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (50) (48)
Parasite Metazoan 3 (6%) 1 (2%) 2 (4%)
Intestine Large, Colon (50) (49) (48)
Parasite Metazoan 6 (12%) 5 (10%) 7 (15%)
Intestine Large, Rectum (49) (49) (45)
Parasite Metazoan 7 (14%) 6 (12%) 10 (22%)
Intestine Small, Duodenum (48) (48) (47)
Erosion, Multiple 1 (2%)
Intussusception 1 (2%)
Liver (50) (50) (50)
Angiectasis, Focal 1 (2%) 1 (2%)
Angiectasis, Multifocal 1 (2%)
Basophilic Focus 37 (74%) 35 (70%) 26 (52%)
Clear Cell Focus 21 (42%) 19 (38%) 16 (32%)
Congestion 1 (2%)
Degeneration, Cystic 5 (10%) 11 (22%) 2 (4%)
Degeneration, Cystic, Focal 1 (2%) 6 (12%)
Fatty Change, Diffuse 2 (4%) 2 (4%)
Granuloma, Multiple 2 (4%) 7 (14%) 3 (6%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 4 (8%) 5 (10%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Necrosis, Multifocal 1 (2%)
Bile Duct, Dysplasia, Focal 2 (4%)
Bile Duct, Fibrosis, Focal 2 (4%)
Bile Duct, Hyperplasia 45 (90%) 41 (82%) 42 (84%)
Bile Duct, Hyperplasia, Focal 1 (2%)
Biliary Tract, Cyst Multilocular 1 (2%)
Centrilobular, Fatty Change 10 (20%) 6 (12%) 3 (6%)
Centrilobular, Necrosis 2 (4%) 8 (16%) 12 (24%)
Centrilobular, Necrosis, Focal 1 (2%)
Centrilobular, Necrosis, Multifocal 1 (2%)
Mesentery (5) (8) (9)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Necrosis, Focal 3 (60%) 4 (50%) 6 (67%)
Pancreas (50) (50) (47)
Inflammation, Chronic, Multifocal 1 (2%)
Inflammation, Multifocal, Subacute 1 (2%)
Acinus, Atrophy, Focal 6 (12%) 6 (12%) 4 (9%)
Acinus, Atrophy, Multifocal 13 (26%) 8 (16%) 12 (26%)
Acinus, Hyperplasia, Focal 10 (20%) 18 (36%) 16 (34%)
Acinus, Hyperplasia, Multifocal 1 (2%) 5 (10%)
Artery, Hypertrophy 2 (4%)
Artery, Inflammation, Subacute 1 (2%)
Artery, Mineralization 1 (2%)
Duct, Ectasia 1 (2%)
Stomach, Forestomach (50) (50) (50)
Edema 2 (4%)
Erosion 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 5 (10%) 2 (4%)
Inflammation, Subacute 2 (4%) 5 (10%) 2 (4%)
Perforation 2 (4%)
Ulcer 1 (2%) 1 (2%)
Ulcer, Multiple 1 (2%)
Stomach, Glandular (50) (50) (50)
Erosion 1 (2%) 1 (2%)
Inflammation, Subacute 2 (4%)
Mineralization 5 (10%) 11 (22%) 6 (12%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2)
Aorta, Mineralization 2 (100%)
Heart (50) (50) (50)
Cardiomyopathy 35 (70%) 32 (64%) 36 (72%)
Congestion 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 1 (2%)
Mineralization, Multifocal 1 (2%)
Thrombosis 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (47)
Focal Cellular Change 6 (12%) 5 (10%) 3 (6%)
Focal Cellular Change, Multiple 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%)
Hemorrhage, Focal 1 (2%)
Hyperplasia, Focal 1 (2%)
Hypertrophy, Focal 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Capsule, Accessory Adrenal Cortical Nodule 2 (4%) 4 (8%)
Adrenal Gland, Medulla (50) (49) (46)
Hemorrhage 2 (4%)
Hyperplasia, Focal 6 (12%) 14 (29%) 8 (17%)
Pigmentation, Hemosiderin 2 (4%)
Islets, Pancreatic (50) (50) (47)
Hyperplasia 1 (2%) 1 (2%)
Hyperplasia, Focal 5 (10%) 1 (2%)
Parathyroid Gland (49) (48) (47)
Hyperplasia 3 (6%) 4 (8%) 3 (6%)
Pituitary Gland (50) (49) (50)
Pars Distalis, Angiectasis 16 (32%) 20 (41%) 17 (34%)
Pars Distalis, Cyst 3 (6%) 4 (8%) 2 (4%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia, Focal 13 (26%) 9 (18%) 12 (24%)
Pars Distalis, Pigmentation, Hematoidin 2 (4%)
Pars Distalis, Pigmentation, Hemosiderin 5 (10%) 14 (29%) 6 (12%)
Pars Nervosa, Cyst 1 (2%)
Thyroid Gland (50) (50) (50)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia, Focal 3 (6%) 7 (14%) 4 (8%)
C-Cell, Hyperplasia, Multifocal 1 (2%) 2 (4%)
Follicle, Cyst 1 (2%) 5 (10%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1)
Inflammation, Subacute 1 (100%)
Epididymis (50) (50) (50)
Inflammation, Subacute 1 (2%)
Preputial Gland (49) (50) (47)
Foreign Body 1 (2%)
Inflammation, Acute, Suppurative 1 (2%)
Inflammation, Focal, Granulomatous 1 (2%)
Inflammation, Granulomatous 4 (8%) 3 (6%)
Inflammation, Subacute 6 (12%) 11 (22%) 5 (11%)
Duct, Cyst 1 (2%) 5 (10%) 1 (2%)
Prostate (50) (50) (50)
Inflammation, Acute, Suppurative 1 (2%)
Inflammation, Subacute 23 (46%) 19 (38%) 18 (36%)
Seminal Vesicle (47) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Dilatation 1 (2%) 1 (2%)
Inflammation, Acute, Suppurative 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Subacute 1 (2%)
Testes (50) (50) (50)
Atrophy 6 (12%) 3 (6%) 11 (22%)
Developmental Malformation 1 (2%)
Mineralization 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (2)
Anemia 2 (100%)
Bone Marrow (50) (50) (50)
Hyperplasia 5 (10%) 4 (8%) 4 (8%)
Lymph Node (50) (50) (48)
Deep Cervical, Ectasia 1 (2%)
Deep Cervical, Hyperplasia 1 (2%)
Inguinal, Ectasia 1 (2%)
Inguinal, Inflammation, Acute, Suppurative 1 (2%)
Mediastinal, Congestion 1 (2%) 1 (2%) 2 (4%)
Mediastinal, Ectasia 2 (4%)
Mediastinal, Pigmentation, Hemosiderin 1 (2%)
Pancreatic, Ectasia 1 (2%) 1 (2%)
Lymph Node, Mandibular (49) (49) (47)
Ectasia 9 (18%) 6 (12%) 6 (13%)
Hyperplasia 1 (2%) 1 (2%)
Lymph Node, Mesenteric (48) (49) (46)
Congestion 2 (4%)
Spleen (50) (50) (49)
Fibrosis, Focal 1 (2%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 9 (18%) 5 (10%) 5 (10%)
Hemorrhage 1 (2%)
Necrosis, Focal 1 (2%)
Necrosis, Multifocal 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Thymus (43) (48) (38)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (45) (49) (47)
Duct, Cyst 21 (47%) 27 (55%) 24 (51%)
Skin (50) (50) (49)
Inflammation, Acute, Focal, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Fibrous Osteodystrophy 4 (8%) 2 (4%)
Skeletal Muscle (1) (2)
Inflammation, Granulomatous, Multifocal 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Compression 4 (8%) 2 (4%) 3 (6%)
Fungus 1 (2%)
Hemorrhage, Multifocal 1 (2%) 1 (2%) 2 (4%)
Hydrocephalus 1 (2%)
Inflammation, Acute, Suppurative 1 (2%)
Necrosis 1 (2%)
Thrombosis, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Congestion 7 (14%) 9 (18%) 9 (18%)
Foreign Body 7 (14%) 8 (16%) 8 (16%)
Fungus 1 (2%)
Granuloma, Multiple 6 (12%) 2 (4%)
Hemorrhage, Multifocal 1 (2%)
Infiltration Cellular, Multifocal, Histiocyte 1 (2%) 2 (4%) 1 (2%)
Inflammation, Acute, Focal, Suppurative 2 (4%)
Necrosis, Multifocal 1 (2%) 1 (2%)
Pigmentation, Multifocal 1 (2%)
Thrombosis, Multiple 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 3 (6%)
Alveolar Epithelium, Hyperplasia, Multifocal 1 (2%)
Fat, Mediastinum, Necrosis, Multifocal 1 (2%)
Mediastinum, Foreign Body 1 (2%) 1 (2%)
Pleura, Fibrosis, Focal 1 (2%)
Nose (50) (49) (50)
Foreign Body 4 (8%) 10 (20%) 4 (8%)
Fungus 13 (26%) 10 (20%) 10 (20%)
Inflammation, Acute, Suppurative 13 (26%) 13 (27%) 10 (20%)
Mucosa, Hyperkeratosis, Focal 1 (2%)
Mucosa, Hyperplasia, Focal 1 (2%)
Nasolacrimal Duct, Cyst 1 (2%)
Nasolacrimal Duct, Foreign Body 1 (2%) 2 (4%) 1 (2%)
Nasolacrimal Duct, Inflammation, Acute,
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Suppurative 5 (10%) 1 (2%)
Nasolacrimal Duct, Inflammation, Subacute 4 (8%) 10 (20%) 5 (10%)
Nasopharyngeal Duct, Cyst 1 (2%)
Nasopharyngeal Duct, Foreign Body 1 (2%)
Nasopharyngeal Duct, Inflammation, Subacute 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (2) (3)
Cataract 2 (50%) 2 (100%) 3 (100%)
Retina, Degeneration 3 (75%) 2 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Developmental Malformation 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Inflammation, Acute, Multifocal, Suppurative 1 (2%)
Nephropathy, Chronic 42 (84%) 43 (86%) 43 (86%)
Capsule, Fibrosis, Focal 1 (2%)
Cortex, Cyst 3 (6%) 3 (6%)
Papilla, Necrosis 1 (2%)
Pelvis, Inflammation, Acute, Suppurative 1 (2%)
Renal Tubule, Dilatation, Multifocal 1 (2%)
Renal Tubule, Mineralization, Multifocal 1 (2%)
Renal Tubule, Pigmentation, Hemosiderin,
Multifocal 1 (2%) 1 (2%)
Urinary Bladder (50) (50) (49)
Hemorrhage 1 (2%)
Inflammation, Acute, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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