TR 382 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
FURFURAL
NTP Experiment-Test: 05005-07 Report: PEIRPT05
Study Type: CHRONIC Date: 09/03/94
Route: GAVAGE Time: 04:58:00
Facility: Southern Research Institute
Chemical CAS #: 98-01-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dead 9 5 4
Moribund 9 11 9
Dosing Accident 4 2 19
Survivors
Dead 1
Terminal Sacrifice 28 32 17
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (50) (49)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Liver (50) (50) (50)
Mesentery (8) (10) (11)
Sarcoma 1 (13%)
Pancreas (50) (50) (48)
Acinus, Adenoma 1 (2%)
Pharynx (1)
Squamous Cell Papilloma 1 (100%)
Stomach, Forestomach (50) (50) (50)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Stomach, Glandular (50) (50) (50)
Tongue (2)
Squamous Cell Papilloma 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (50) (50)
Adenoma 1 (2%)
Adrenal Gland, Medulla (47) (50) (50)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Complex 1 (2%) 1 (2%)
Pheochromocytoma Benign 2 (4%) 1 (2%)
Islets, Pancreatic (50) (50) (48)
Adenoma 1 (2%) 1 (2%)
Page 2
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pituitary Gland (49) (50) (50)
Pars Distalis, Adenoma 23 (47%) 28 (56%) 12 (24%)
Thyroid Gland (50) (50) (50)
C-Cell, Adenoma 4 (8%) 2 (4%) 1 (2%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (49) (47)
Adenoma 2 (4%) 4 (8%) 1 (2%)
Carcinoma 2 (4%) 1 (2%) 2 (4%)
Ovary (50) (50) (50)
Granulosa Cell Tumor Malignant 1 (2%)
Uterus (50) (50) (49)
Adenoma 1 (2%)
Hemangioma 1 (2%)
Polyp 1 (2%)
Polyp Stromal 10 (20%) 8 (16%) 13 (27%)
Polyp Stromal, Multiple 2 (4%) 1 (2%)
Sarcoma Stromal 2 (4%)
Cervix, Sarcoma Stromal 2 (4%)
Vagina (1)
Polyp 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (2)
Bone Marrow (50) (47) (50)
Lymph Node (50) (50) (49)
Lymph Node, Mandibular (50) (50) (49)
Lymph Node, Mesenteric (49) (50) (49)
Spleen (50) (50) (50)
Thymus (47) (48) (49)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (50)
Adenocarcinoma 2 (4%) 3 (6%) 1 (2%)
Fibroadenoma 10 (20%) 10 (20%) 11 (22%)
Fibroadenoma, Multiple 2 (4%) 4 (8%) 5 (10%)
Skin (50) (50) (50)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Cranium, Fibrosarcoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49)
Glioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Mediastinum, Schwannoma Malignant 1 (2%)
Nose (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Cortex, Adenoma 1 (2%)
Urinary Bladder (49) (50) (48)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Page 4
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 18 (36%) 15 (30%) 8 (16%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 43 44 33
Total Primary Neoplasms 85 93 63
Total Animals with Benign Neoplasms 36 38 32
Total Benign Neoplasms 56 66 50
Total Animals with Malignant Neoplasms 24 24 9
Total Malignant Neoplasms 29 27 13
Total Animals with Metastatic Neoplasms 2
Total Metastatic Neoplasm 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Dosing Accident 6 7 8
Moribund 11 11 11
Dead 2 4 7
Survivors
Terminal Sacrifice 31 28 24
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (49) (49) (47)
Fibrosarcoma 1 (2%)
Polyp Adenomatous 1 (2%)
Liver (50) (50) (50)
Cholangiocarcinoma 2 (4%)
Chordoma, Metastatic, Uncertain Primary Site 1 (2%)
Hepatocellular Adenoma 1 (2%)
Mesentery (5) (8) (9)
Sarcoma 2 (22%)
Pancreas (50) (50) (47)
Acinus, Adenoma 2 (4%) 3 (6%) 2 (4%)
Acinus, Adenoma, Multiple 1 (2%)
Stomach, Forestomach (50) (50) (50)
Leiomyosarcoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 2 (4%)
Stomach, Glandular (50) (50) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Chordoma, Metastatic, Uncertain Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (47)
Adrenal Gland, Medulla (50) (49) (46)
Pheochromocytoma Malignant 2 (4%) 2 (4%) 1 (2%)
Pheochromocytoma Malignant, Multiple 1 (2%)
Pheochromocytoma Benign 9 (18%) 12 (24%) 4 (9%)
Page 7
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pheochromocytoma Benign, Multiple 2 (4%) 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (47)
Adenoma 4 (8%) 5 (10%) 2 (4%)
Carcinoma 1 (2%) 1 (2%) 2 (4%)
Pituitary Gland (50) (49) (50)
Pars Distalis, Adenoma 19 (38%) 18 (37%) 15 (30%)
Thyroid Gland (50) (50) (50)
C-Cell, Adenoma 3 (6%) 2 (4%) 2 (4%)
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50)
Preputial Gland (49) (50) (47)
Adenoma 1 (2%) 4 (8%) 2 (4%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Prostate (50) (50) (50)
Seminal Vesicle (47) (50) (50)
Testes (50) (50) (50)
Interstitial Cell, Adenoma 2 (4%) 9 (18%) 4 (8%)
Interstitial Cell, Adenoma, Multiple 36 (72%) 35 (70%) 35 (70%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Lymph Node (50) (50) (48)
Lymph Node, Mandibular (49) (49) (47)
Lymph Node, Mesenteric (48) (49) (46)
Spleen (50) (50) (49)
Sarcoma 1 (2%)
Thymus (43) (48) (38)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (45) (49) (47)
Adenocarcinoma 1 (2%)
Fibroadenoma 1 (2%) 1 (2%)
Fibroadenoma, Multiple 1 (2%)
Skin (50) (50) (49)
Basal Cell Carcinoma 2 (4%)
Keratoacanthoma 2 (4%) 1 (2%) 4 (8%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 4 (8%) 5 (10%) 2 (4%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (2)
Chordoma, Metastatic, Uncertain Primary Site 1 (50%)
Fibrosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Astrocytoma Malignant 1 (2%)
Granular Cell Tumor Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%)
Basal Cell Carcinoma, Metastatic, Skin 1 (2%)
Chordoma, Metastatic, Uncertain Primary Site 1 (2%)
Nose (50) (49) (50)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1) (1)
Pinna, Schwannoma Benign 1 (100%) 1 (100%)
Zymbal's Gland (3)
Adenoma 2 (67%)
Carcinoma 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Urinary Bladder (50) (50) (49)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 13 (26%) 15 (30%) 15 (30%)
Mesothelioma Malignant 3 (6%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05005-07 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FURFURAL Date: 09/03/94
Route: GAVAGE Time: 04:58:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE 30. 60.
CONTROL MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 46 44
Total Primary Neoplasms 122 131 106
Total Animals with Benign Neoplasms 47 46 43
Total Benign Neoplasms 94 101 79
Total Animals with Malignant Neoplasms 23 24 26
Total Malignant Neoplasms 28 30 27
Total Animals with Metastatic Neoplasms 2 1
Total Metastatic Neoplasm 4 4
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
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