TR 382 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst FURFURAL DATE: 09/03/94
EXPERIMENT: 05005 TEST: 07 TIME: 05:09:48
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56177
PATHOLOGIST: H. GILES S. EUSTIS CAS: 98-01-1
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst FURFURAL DATE: 09/03/94
EXPERIMENT: 05005 TEST: 07 TIME: 05:09:48
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56177
PATHOLOGIST: H. GILES S. EUSTIS CAS: 98-01-1
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst FURFURAL DATE: 09/03/94
EXPERIMENT: 05005 TEST: 07 TIME: 05:09:48
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56177
PATHOLOGIST: H. GILES S. EUSTIS CAS: 98-01-1
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF FURFURAL
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Testes Adenoma
Zymbal's Gland Carcinoma or Adenoma
All Organs Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Mammary Gland Fibroadenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/50 (22%) 13/49 (27%) 5/46 (11%) | 2/47 (4%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 34.3% 40.4% 21.2% | 7.0% 3.1% 0.0% |
|TERMINAL (d) | 10/31 (32%) 10/28 (36%) 4/21 (19%) | 1/27 (4%) 1/32 (3%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 603 484 582 | 703 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.251N P=0.333 P=0.251N | P=0.187N P=0.446N P=0.323N |
|INCIDENTAL TUMOR | P=0.240N P=0.273 P=0.200N | P=0.143N P=0.482N P=0.223N |
|LOGISTIC REGRESSION | P=0.126N P=0.489 P=0.147N | P=0.172N P=0.462N P=0.294N |
|COCHRAN-ARMITAGE | P=0.114N | P=0.132N |
|FISHER EXACT | P=0.385 P=0.117N | P=0.477N P=0.232N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 3/49 (6%) 1/46 (2%) | 1/47 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 6.5% 9.0% 4.8% | 2.9% 0.0% 3.2% |
|TERMINAL (d) | 2/31 (6%) 0/28 (0%) 1/21 (5%) | 0/27 (0%) 0/32 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 682 729 (T) | 645 --- 602 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.508N P=0.487 P=0.635N | P=0.625 P=0.483N P=0.710 |
|INCIDENTAL TUMOR | P=0.283N P=0.505N P=0.635N | P=0.662 P=0.536N P=0.765 |
|LOGISTIC REGRESSION | P=0.461N P=0.464N P=0.635N | P=0.648N P=0.489N P=0.756N |
|COCHRAN-ARMITAGE | P=0.431N | P=0.659N |
|FISHER EXACT | P=0.490 P=0.532N | P=0.485N P=0.737N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/50 (22%) 16/49 (33%) 6/46 (13%) | 3/47 (6%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 34.3% 45.8% 25.8% | 9.8% 6.3% 3.2% |
|TERMINAL (d) | 10/31 (32%) 10/28 (36%) 5/21 (24%) | 1/27 (4%) 2/32 (6%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 603 484 582 | 645 729 (T) 602 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.380N P=0.145 P=0.373N | P=0.314N P=0.435N P=0.417N |
|INCIDENTAL TUMOR | P=0.271N P=0.210 P=0.314N | P=0.245N P=0.487N P=0.293N |
|LOGISTIC REGRESSION | P=0.211N P=0.241 P=0.236N | P=0.261N P=0.466N P=0.338N |
|COCHRAN-ARMITAGE | P=0.189N | P=0.203N |
|FISHER EXACT | P=0.168 P=0.190N | P=0.470N P=0.285N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 4/50 (8%) 2/47 (4%) | 2/50 (4%) 4/49 (8%) 1/47 (2%) |
|ADJUSTED (b) | 2.1% 13.7% 9.5% | 7.1% 12.5% 4.0% |
|TERMINAL (d) | 0/31 (0%) 3/28 (11%) 2/21 (10%) | 2/28 (7%) 4/32 (13%) 0/17 (0%) |
|FIRST INCIDENCE (DAYS) | 371 708 729 (T) | 729 (T) 729 (T) 694 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.286 P=0.162 P=0.408 | P=0.583N P=0.399 P=0.635N |
|INCIDENTAL TUMOR | P=0.310 P=0.175 P=0.357 | P=0.530N P=0.399 P=0.557N |
|LOGISTIC REGRESSION | P=0.373 P=0.186 P=0.493 | P=0.549N P=0.398 P=0.616N |
|COCHRAN-ARMITAGE | P=0.391 | P=0.431N |
|FISHER EXACT | P=0.187 P=0.484 | P=0.329 P=0.523N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/49 (2%) 1/50 (2%) 1/47 (2%) | 2/50 (4%) 1/49 (2%) 2/47 (4%) |
|ADJUSTED (b) | 3.2% 3.6% 4.8% | 7.1% 3.1% 10.6% |
|TERMINAL (d) | 1/31 (3%) 1/28 (4%) 1/21 (5%) | 2/28 (7%) 1/32 (3%) 1/17 (6%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) | 729 (T) 729 (T) 709 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.538 P=0.739 P=0.673 | P=0.458 P=0.453N P=0.521 |
|INCIDENTAL TUMOR | P=0.538 P=0.739 P=0.673 | P=0.529 P=0.453N P=0.607 |
|LOGISTIC REGRESSION | P=0.538 P=0.739 P=0.673 | P=0.488 P=0.453N P=0.558 |
|COCHRAN-ARMITAGE | P=0.630 | P=0.588 |
|FISHER EXACT | P=0.747N P=0.742 | P=0.508N P=0.668 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 5/50 (10%) 3/47 (6%) | 4/50 (8%) 5/49 (10%) 3/47 (6%) |
|ADJUSTED (b) | 5.3% 17.1% 14.3% | 14.3% 15.6% 14.2% |
|TERMINAL (d) | 1/31 (3%) 4/28 (14%) 3/21 (14%) | 4/28 (14%) 5/32 (16%) 1/17 (6%) |
|FIRST INCIDENCE (DAYS) | 371 708 729 (T) | 729 (T) 729 (T) 694 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.263 P=0.188 P=0.358 | P=0.487 P=0.585 P=0.582 |
|INCIDENTAL TUMOR | P=0.282 P=0.204 P=0.320 | P=0.575 P=0.585 P=0.616N |
|LOGISTIC REGRESSION | P=0.367 P=0.233 P=0.468 | P=0.535 P=0.585 P=0.629 |
|COCHRAN-ARMITAGE | P=0.401 | P=0.462N |
|FISHER EXACT | P=0.226 P=0.480 | P=0.487 P=0.535N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 5/50 (10%) 2/47 (4%) | 0/50 (0%) 1/50 (2%) 1/48 (2%) |
|ADJUSTED (b) | 12.9% 16.6% 7.0% | 0.0% 3.1% 2.9% |
|TERMINAL (d) | 4/31 (13%) 4/28 (14%) 1/21 (5%) | 0/28 (0%) 1/32 (3%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 674 481 | --- 729 (T) 561 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.443N P=0.453 P=0.489N | P=0.256 P=0.527 P=0.440 |
|INCIDENTAL TUMOR | P=0.432N P=0.541 P=0.543N | P=0.219 P=0.527 P=0.362 |
|LOGISTIC REGRESSION | P=0.339N P=0.535 P=0.390N | P=0.316 P=0.527 P=0.517 |
|COCHRAN-ARMITAGE | P=0.310N | P=0.324 |
|FISHER EXACT | P=0.500 P=0.369N | P=0.500 P=0.490 |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 2/47 (4%) | 0/50 (0%) 0/50 (0%) 0/48 (0%) |
|ADJUSTED (b) | 3.1% 2.4% 9.5% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/28 (0%) 2/21 (10%) | 0/28 (0%) 0/32 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 697 585 729 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.311 P=0.743N P=0.391 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.438 P=0.633N P=0.554 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.344 P=0.762 P=0.427 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.359 | (e) |
|FISHER EXACT | P=0.753N P=0.477 | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 6/50 (12%) 4/47 (9%) | 0/50 (0%) 1/50 (2%) 1/48 (2%) |
|ADJUSTED (b) | 15.6% 18.6% 16.3% | 0.0% 3.1% 2.9% |
|TERMINAL (d) | 4/31 (13%) 4/28 (14%) 3/21 (14%) | 0/28 (0%) 1/32 (3%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 697 585 481 | --- 729 (T) 561 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.511 P=0.468 P=0.583 | P=0.256 P=0.527 P=0.440 |
|INCIDENTAL TUMOR | P=0.543N P=0.614 P=0.638 | P=0.219 P=0.527 P=0.362 |
|LOGISTIC REGRESSION | P=0.511N P=0.555 P=0.583N | P=0.316 P=0.527 P=0.517 |
|COCHRAN-ARMITAGE | P=0.474N | P=0.324 |
|FISHER EXACT | P=0.500 P=0.540N | P=0.500 P=0.490 |
|=================================================================================================================================|
| |
|Liver |
| Cholangiocarcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 6.6% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/28 (0%) 1/24 (4%) | 0/28 (0%) 0/32 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 564 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.086 (e) P=0.220 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.123 (e) P=0.271 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.094 (e) P=0.236 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.095 | (e) |
|FISHER EXACT | (e) P=0.247 | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 4.2% | 0.0% 5.9% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/28 (0%) 1/24 (4%) | 0/28 (0%) 1/32 (3%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) | --- 668 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.236 (e) P=0.449 | P=0.608 P=0.261 (e) |
|INCIDENTAL TUMOR | P=0.236 (e) P=0.449 | P=0.647N P=0.234 (e) |
|LOGISTIC REGRESSION | P=0.236 (e) P=0.449 | P=0.633 P=0.245 (e) |
|COCHRAN-ARMITAGE | P=0.270 | P=0.667N |
|FISHER EXACT | (e) P=0.500 | P=0.247 (e) |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 0/50 (0%) | 2/50 (4%) 3/50 (6%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 3.6% 0.0% | 5.4% 9.4% 5.6% |
|TERMINAL (d) | 0/31 (0%) 1/28 (4%) 0/24 (0%) | 0/28 (0%) 3/32 (9%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- | 571 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.700 P=0.480 (e) | P=0.541N P=0.542 P=0.615N |
|INCIDENTAL TUMOR | P=0.700 P=0.480 (e) | P=0.503N P=0.472 P=0.555N |
|LOGISTIC REGRESSION | P=0.700 P=0.480 (e) | P=0.478N P=0.514 P=0.545N |
|COCHRAN-ARMITAGE | P=0.730N | P=0.399N |
|FISHER EXACT | P=0.500 (e) | P=0.500 P=0.500N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 1/50 (2%) | 12/50 (24%) 14/50 (28%) 16/50 (32%) |
|ADJUSTED (b) | 3.2% 3.6% 3.1% | 36.7% 39.5% 60.2% |
|TERMINAL (d) | 1/31 (3%) 1/28 (4%) 0/24 (0%) | 8/28 (29%) 11/32 (34%) 8/18 (44%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 655 | 606 582 602 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.596 P=0.739 P=0.732 | P=0.032 * P=0.549 P=0.045 * |
|INCIDENTAL TUMOR | P=0.617N P=0.739 P=0.660N | P=0.073 P=0.418 P=0.092 |
|LOGISTIC REGRESSION | P=0.631 P=0.739 P=0.755 | P=0.052 P=0.460 P=0.062 |
|COCHRAN-ARMITAGE | P=0.641 | P=0.218 |
|FISHER EXACT | P=0.753N P=0.753N | P=0.410 P=0.252 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 1/50 (2%) | 14/50 (28%) 17/50 (34%) 16/50 (32%) |
|ADJUSTED (b) | 3.2% 7.1% 3.1% | 40.1% 48.2% 60.2% |
|TERMINAL (d) | 1/31 (3%) 2/28 (7%) 0/24 (0%) | 8/28 (29%) 14/32 (44%) 8/18 (44%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 655 | 571 582 602 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.564 P=0.464 P=0.732 | P=0.072 P=0.482 P=0.101 |
|INCIDENTAL TUMOR | P=0.621N P=0.464 P=0.660N | P=0.150 P=0.325 P=0.200 |
|LOGISTIC REGRESSION | P=0.607 P=0.464 P=0.755 | P=0.118 P=0.378 P=0.149 |
|COCHRAN-ARMITAGE | P=0.622N | P=0.374 |
|FISHER EXACT | P=0.500 P=0.753N | P=0.333 P=0.414 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Mesentery |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 5.3% | 3.2% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/28 (0%) 0/24 (0%) | 0/28 (0%) 0/32 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 582 | 692 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.097 (e) P=0.252 | P=0.294N P=0.482N P=0.543N |
|INCIDENTAL TUMOR | P=0.184 (e) P=0.371 | P=0.211N P=0.536N P=0.398N |
|LOGISTIC REGRESSION | P=0.099 (e) P=0.243 | P=0.292N P=0.494N P=0.543N |
|COCHRAN-ARMITAGE | P=0.095 | P=0.272N |
|FISHER EXACT | (e) P=0.247 | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Papilloma Squamous or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 5.4% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/28 (0%) 0/24 (0%) | 0/28 (0%) 1/32 (3%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- 582 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.602 P=0.254 (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.568 P=0.194 (e) |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.663 P=0.236 (e) |
|COCHRAN-ARMITAGE | (e) | P=0.667N |
|FISHER EXACT | (e) (e) | P=0.247 (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 5.4% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/28 (0%) 0/24 (0%) | 0/28 (0%) 1/32 (3%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- 582 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.602 P=0.254 (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.568 P=0.194 (e) |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.663 P=0.236 (e) |
|COCHRAN-ARMITAGE | (e) | P=0.667N |
|FISHER EXACT | (e) (e) | P=0.247 (e) |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 2/47 (4%) | 0/50 (0%) 0/50 (0%) 1/48 (2%) |
|ADJUSTED (b) | 9.7% 10.7% 9.5% | 0.0% 0.0% 5.6% |
|TERMINAL (d) | 3/31 (10%) 3/28 (11%) 2/21 (10%) | 0/28 (0%) 0/32 (0%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.592N P=0.617 P=0.676N | P=0.203 (e) P=0.412 |
|INCIDENTAL TUMOR | P=0.592N P=0.617 P=0.676N | P=0.203 (e) P=0.412 |
|LOGISTIC REGRESSION | P=0.592N P=0.617 P=0.676N | P=0.203 (e) P=0.412 |
|COCHRAN-ARMITAGE | P=0.440N | P=0.264 |
|FISHER EXACT | P=0.661N P=0.530N | (e) P=0.490 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/50 (38%) 18/49 (37%) 15/50 (30%) | 23/49 (47%) 28/50 (56%) 12/50 (24%) |
|ADJUSTED (b) | 53.2% 52.1% 51.5% | 61.1% 71.4% 46.8% |
|TERMINAL (d) | 15/31 (48%) 12/28 (43%) 11/24 (46%) | 13/27 (48%) 21/32 (66%) 6/18 (33%) |
|FIRST INCIDENCE (DAYS) | 398 585 438 | 571 562 438 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.494N P=0.579N P=0.525N | P=0.215N P=0.455 P=0.210N |
|INCIDENTAL TUMOR | P=0.369N P=0.467N P=0.551N | P=0.074N P=0.175 P=0.046N* |
|LOGISTIC REGRESSION | P=0.246N P=0.417N P=0.281N | P=0.060N P=0.292 P=0.055N |
|COCHRAN-ARMITAGE | P=0.231N | P=0.013N* |
|FISHER EXACT | P=0.531N P=0.263N | P=0.242 P=0.014N* |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 4.6% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 0/28 (0%) 0/24 (0%) | 0/28 (0%) 0/32 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 444 --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.095N P=0.227N P=0.237N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.197N P=0.500N P=0.371N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.074N P=0.208N P=0.183N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.097N | (e) |
|FISHER EXACT | P=0.247N P=0.247N | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 4/50 (8%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 6.5% 2.6% 16.7% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/31 (6%) 0/28 (0%) 4/24 (17%) | 0/28 (0%) 0/32 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 666 729 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.162 P=0.501N P=0.223 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.196 P=0.354N P=0.223 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.195 P=0.474N P=0.223 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.238 | (e) |
|FISHER EXACT | P=0.500N P=0.339 | (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 6.5% 3.6% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/31 (6%) 1/28 (4%) 0/24 (0%) | 0/28 (0%) 0/32 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.185N P=0.536N P=0.296N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.185N P=0.536N P=0.296N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.185N P=0.536N P=0.296N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.143N | (e) |
|FISHER EXACT | P=0.500N P=0.247N | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 2/50 (4%) 4/50 (8%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 16.9% 6.0% 16.7% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 4/31 (13%) 1/28 (4%) 4/24 (17%) | 0/28 (0%) 0/32 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 444 666 729 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.398N P=0.147N P=0.501N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.420N P=0.170N P=0.580N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.300N P=0.132N P=0.382N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.293N | (e) |
|FISHER EXACT | P=0.134N P=0.370N | (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 5/50 (10%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 14.9% 15.1% 7.1% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/31 (10%) 3/28 (11%) 1/24 (4%) | 0/28 (0%) 0/32 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 583 514 606 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.251N P=0.612 P=0.292N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.157N P=0.574N P=0.140N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.183N P=0.603N P=0.227N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.178N | (e) |
|FISHER EXACT | P=0.630N P=0.218N | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 6.9% 3.4% | 0.0% 2.6% 0.0% |
|TERMINAL (d) | 0/31 (0%) 1/28 (4%) 0/24 (0%) | 0/28 (0%) 0/32 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | --- 709 675 | --- 618 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.310 P=0.221 P=0.480 | P=0.712 P=0.511 (e) |
|INCIDENTAL TUMOR | P=0.499 P=0.386 P=0.773 | P=0.648 P=0.393 (e) |
|LOGISTIC REGRESSION | P=0.348 P=0.252 P=0.496 | P=0.725N P=0.487 (e) |
|COCHRAN-ARMITAGE | P=0.364 | P=0.730N |
|FISHER EXACT | P=0.247 P=0.500 | P=0.500 (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 7/50 (14%) 3/50 (6%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 14.9% 21.3% 10.3% | 0.0% 2.6% 0.0% |
|TERMINAL (d) | 3/31 (10%) 4/28 (14%) 1/24 (4%) | 0/28 (0%) 0/32 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 583 514 606 | --- 618 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.417N P=0.359 P=0.447N | P=0.712 P=0.511 (e) |
|INCIDENTAL TUMOR | P=0.224N P=0.514 P=0.188N | P=0.648 P=0.393 (e) |
|LOGISTIC REGRESSION | P=0.319N P=0.416 P=0.370N | P=0.725N P=0.487 (e) |
|COCHRAN-ARMITAGE | P=0.307N | P=0.730N |
|FISHER EXACT | P=0.380 P=0.357N | P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 2.2% 8.3% | 0.0% 3.1% 5.6% |
|TERMINAL (d) | 0/31 (0%) 0/28 (0%) 2/24 (8%) | 0/28 (0%) 1/32 (3%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | --- 514 729 (T) | --- 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.117 P=0.523 P=0.183 | P=0.240 P=0.527 P=0.412 |
|INCIDENTAL TUMOR | P=0.093 P=0.282 P=0.183 | P=0.240 P=0.527 P=0.412 |
|LOGISTIC REGRESSION | P=0.140 P=0.506 P=0.183 | P=0.240 P=0.527 P=0.412 |
|COCHRAN-ARMITAGE | P=0.143 | P=0.333 |
|FISHER EXACT | P=0.500 P=0.247 | P=0.500 P=0.500 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 8.3% | 0.0% 3.1% 5.6% |
|TERMINAL (d) | 0/31 (0%) 0/28 (0%) 2/24 (8%) | 0/28 (0%) 1/32 (3%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | --- --- 729 (T) | --- 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.071 (e) P=0.183 | P=0.240 P=0.527 P=0.412 |
|INCIDENTAL TUMOR | P=0.071 (e) P=0.183 | P=0.240 P=0.527 P=0.412 |
|LOGISTIC REGRESSION | P=0.071 (e) P=0.183 | P=0.240 P=0.527 P=0.412 |
|COCHRAN-ARMITAGE | P=0.095 | P=0.333 |
|FISHER EXACT | (e) P=0.247 | P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 38/50 (76%) 44/50 (88%) 39/50 (78%) | |
|ADJUSTED (b) | 90.4% 100.0% 100.0% | |
|TERMINAL (d) | 27/31 (87%) 28/28 (100%) 24/24 (100%) | |
|FIRST INCIDENCE (DAYS) | 444 484 481 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.081 P=0.122 P=0.112 | |
|INCIDENTAL TUMOR | P=0.343 P=0.036 * P=0.471 | |
|LOGISTIC REGRESSION | P=0.453 P=0.148 P=0.514 | |
|COCHRAN-ARMITAGE | P=0.453 | |
|FISHER EXACT | P=0.096 P=0.500 | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 2/50 (4%) | 4/50 (8%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 12.2% 7.1% 8.3% | 14.3% 5.4% 5.6% |
|TERMINAL (d) | 3/31 (10%) 2/28 (7%) 2/24 (8%) | 4/28 (14%) 1/32 (3%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | 583 729 (T) 729 (T) | 729 (T) 599 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.341N P=0.366N P=0.436N | P=0.201N P=0.284N P=0.331N |
|INCIDENTAL TUMOR | P=0.307N P=0.395N P=0.391N | P=0.220N P=0.325N P=0.331N |
|LOGISTIC REGRESSION | P=0.271N P=0.303N P=0.359N | P=0.170N P=0.315N P=0.331N |
|COCHRAN-ARMITAGE | P=0.253N | P=0.119N |
|FISHER EXACT | P=0.339N P=0.339N | P=0.339N P=0.181N |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 2/50 (4%) 2/50 (4%) | 4/50 (8%) 3/50 (6%) 1/50 (2%) |
|ADJUSTED (b) | 15.3% 7.1% 8.3% | 14.3% 8.5% 5.6% |
|TERMINAL (d) | 4/31 (13%) 2/28 (7%) 2/24 (8%) | 4/28 (14%) 2/32 (6%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | 583 729 (T) 729 (T) | 729 (T) 599 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.217N P=0.244N P=0.310N | P=0.233N P=0.434N P=0.331N |
|INCIDENTAL TUMOR | P=0.193N P=0.267N P=0.272N | P=0.251N P=0.478N P=0.331N |
|LOGISTIC REGRESSION | P=0.160N P=0.185N P=0.238N | P=0.196N P=0.472N P=0.331N |
|COCHRAN-ARMITAGE | P=0.147N | P=0.133N |
|FISHER EXACT | P=0.218N P=0.218N | P=0.500N P=0.181N |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 12/50 (24%) 9/50 (18%) 14/50 (28%) |
|ADJUSTED (b) | | 36.4% 23.8% 51.0% |
|TERMINAL (d) | | 8/28 (29%) 5/32 (16%) 6/18 (33%) |
|FIRST INCIDENCE (DAYS) | | 585 599 327 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.114 P=0.230N P=0.117 |
|INCIDENTAL TUMOR | | P=0.199 P=0.376N P=0.239 |
|LOGISTIC REGRESSION | | P=0.214 P=0.283N P=0.219 |
|COCHRAN-ARMITAGE | | P=0.360 |
|FISHER EXACT | | P=0.312N P=0.410 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | | 5.8% 5.1% 0.0% |
|TERMINAL (d) | | 0/28 (0%) 1/32 (3%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | | 605 388 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.231N P=0.662N P=0.302N |
|INCIDENTAL TUMOR | | P=0.094N P=0.567N P=0.235N |
|LOGISTIC REGRESSION | | P=0.157N P=0.666 P=0.253N |
|COCHRAN-ARMITAGE | | P=0.176N |
|FISHER EXACT | | P=0.691N P=0.247N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 13/50 (26%) 11/50 (22%) 14/50 (28%) |
|ADJUSTED (b) | | 38.0% 28.1% 51.0% |
|TERMINAL (d) | | 8/28 (29%) 6/32 (19%) 6/18 (33%) |
|FIRST INCIDENCE (DAYS) | | 585 388 327 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.160 P=0.310N P=0.162 |
|INCIDENTAL TUMOR | | P=0.303 P=0.397N P=0.299 |
|LOGISTIC REGRESSION | | P=0.318 P=0.387N P=0.300 |
|COCHRAN-ARMITAGE | | P=0.453 |
|FISHER EXACT | | P=0.408N P=0.500 |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.6% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/31 (3%) 0/28 (0%) 0/24 (0%) | 0/28 (0%) 0/32 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 484 --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.107N P=0.238N P=0.265N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.163N P=0.367N P=0.335N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.095N P=0.241N P=0.234N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.097N | (e) |
|FISHER EXACT | P=0.247N P=0.247N | (e) (e) |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.4% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/31 (3%) 0/28 (0%) 0/24 (0%) | 0/28 (0%) 0/32 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 484 --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.042N* P=0.113N P=0.140N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.034N* P=0.078N P=0.085N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.037N* P=0.123N P=0.119N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.038N* | (e) |
|FISHER EXACT | P=0.121N P=0.121N | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 13/50 (26%) 15/50 (30%) 15/50 (30%) | 18/50 (36%) 15/50 (30%) 8/50 (16%) |
|ADJUSTED (b) | 37.6% 41.5% 48.3% | 45.0% 42.0% 31.2% |
|TERMINAL (d) | 10/31 (32%) 8/28 (29%) 9/24 (38%) | 8/28 (29%) 12/32 (38%) 3/18 (17%) |
|FIRST INCIDENCE (DAYS) | 448 666 568 | 210 459 602 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.192 P=0.389 P=0.225 | P=0.127N P=0.245N P=0.160N |
|INCIDENTAL TUMOR | P=0.502 P=0.401N P=0.485 | P=0.067N P=0.363N P=0.094N |
|LOGISTIC REGRESSION | P=0.331 P=0.497 P=0.375 | P=0.032N* P=0.319N P=0.035N* |
|COCHRAN-ARMITAGE | P=0.371 | P=0.016N* |
|FISHER EXACT | P=0.412 P=0.412 | P=0.335N P=0.020N* |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 7.8% 9.6% 7.1% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/31 (0%) 2/28 (7%) 0/24 (0%) | 0/28 (0%) 0/32 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 517 668 657 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.458N P=0.635N P=0.517N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.330N P=0.586 P=0.318N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.413N P=0.658 P=0.491N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.412N | (e) |
|FISHER EXACT | P=0.661N P=0.500N | (e) (e) |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 47/50 (94%) 46/50 (92%) 43/50 (86%) | 36/50 (72%) 38/50 (76%) 32/50 (64%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 85.6% 90.3% 91.3% |
|TERMINAL (d) | 31/31 (100%) 28/28 (100%) 24/24 (100%) | 22/28 (79%) 28/32 (88%) 15/18 (83%) |
|FIRST INCIDENCE (DAYS) | 371 484 438 | 571 465 327 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.303 P=0.536 P=0.361 | P=0.105 P=0.431N P=0.131 |
|INCIDENTAL TUMOR | P=0.059N (e) P=0.144N | P=0.256 P=0.377 P=0.326 |
|LOGISTIC REGRESSION | P=0.035N* (e) P=0.081N | P=0.301 P=0.493 P=0.364 |
|COCHRAN-ARMITAGE | P=0.114N | P=0.220N |
|FISHER EXACT | P=0.500N P=0.159N | P=0.410 P=0.260N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 23/50 (46%) 24/50 (48%) 26/50 (52%) | 24/50 (48%) 24/50 (48%) 9/50 (18%) |
|ADJUSTED (b) | 57.0% 58.1% 69.8% | 57.2% 64.1% 35.8% |
|TERMINAL (d) | 14/31 (45%) 11/28 (39%) 13/24 (54%) | 11/28 (39%) 19/32 (59%) 4/18 (22%) |
|FIRST INCIDENCE (DAYS) | 444 514 564 | 210 388 602 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.145 P=0.484 P=0.170 | P=0.048N* P=0.407N P=0.053N |
|INCIDENTAL TUMOR | P=0.542N P=0.361N P=0.571 | P=0.010N* P=0.534N P=0.013N* |
|LOGISTIC REGRESSION | P=0.479 P=0.513N P=0.476 | P=0.004N** P=0.549N P=0.004N** |
|COCHRAN-ARMITAGE | P=0.309 | P=0.001N** |
|FISHER EXACT | P=0.500 P=0.345 | P=0.579N P=0.001N** |
|=================================================================================================================================|
DATE: 09/03/94 EXPERIMENT: 05005 TEST: 07 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FURFURAL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | VEHICLE 30. 60. | VEHICLE 30. 60. |
| | CONTROL MG/KG MG/KG | CONTROL MG/KG MG/KG |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 47/50 (94%) 46/50 (92%) 44/50 (88%) | 43/50 (86%) 44/50 (88%) 33/50 (66%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% | 93.5% 95.6% 91.6% |
|TERMINAL (d) | 31/31 (100%) 28/28 (100%) 24/24 (100%) | 25/28 (89%) 30/32 (94%) 15/18 (83%) |
|FIRST INCIDENCE (DAYS) | 371 484 438 | 210 388 327 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.248 P=0.536 P=0.303 | P=0.349 P=0.343N P=0.372 |
|INCIDENTAL TUMOR | P=0.108N (e) P=0.230N | P=0.165N P=0.599 P=0.290N |
|LOGISTIC REGRESSION | P=0.076N (e) P=0.160N | P=0.104N P=0.594N P=0.159N |
|COCHRAN-ARMITAGE | P=0.187N | P=0.009N** |
|FISHER EXACT | P=0.500N P=0.243N | P=0.500 P=0.017N* |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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