TR 382 Rat Pathology Tables
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
Facility: Southern Research Institute
Chemical CAS #: 98-01-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 6| 6| 6| 7| 5| 5| 7| 7| 7| 1| 2| 7| 7| 7|
DAY ON TEST | 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 2| 8| 9| 3| 6| 8| 3| 3| 3| 7| 1| 3| 3| 3|
| 7| 9| 9| 9| 9| 5| 9| 9| 9| 9| 7| 6| 6| 2| 0| 7| 9| 0| 0| 0| 8| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + M + + + + + + + + + + + + +|
Parasite Metazoan | 2 2|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Fatty Change | |
Granuloma, Multiple | 1 1 1 1 2 1|
Hepatodiaphragmatic Nodule | 2 2 |
Hyperplasia, Focal | |
Necrosis, Focal | 1 2 |
Bile Duct, Hyperplasia | 3 1 1 2 2 1 1 3 1 2 1 1 2 1 1 1 1 1|
Centrilobular, Necrosis | 2 2 1 2 1 1 |
Hepatocyte, Cytomegaly | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis, Focal | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | |
Acinus, Atrophy, Multifocal | 1 2 2 2 |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Multifocal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Subacute | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Mineralization | 1 1 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 6| 6| 6| 7| 5| 5| 7| 7| 7| 1| 2| 7| 7| 7|
DAY ON TEST | 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 2| 8| 9| 3| 6| 8| 3| 3| 3| 7| 1| 3| 3| 3|
| 7| 9| 9| 9| 9| 5| 9| 9| 9| 9| 7| 6| 6| 2| 0| 7| 9| 0| 0| 0| 8| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + M + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X X X |
Hyperplasia | |
Hypertrophy, Focal | 1 |
Capsule, Accessory Adrenal Cortical | |
Nodule | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + + + + + + + + M + + + + + + + + + M + + + +|
Hyperplasia, Focal | 2 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 3 2 2 2 3 3 3 3 3 2|
Pars Distalis, Cyst | X X X X X X X X X X X X X X|
Pars Distalis, Hyperplasia, Focal | 3 2 2 2 2 2 2 2 |
Pars Distalis, Hyperplasia | |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 2 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia, Focal | 1 1 2 1|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Suppurative | 2 2 |
Inflammation, Subacute | |
Duct, Cyst | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydrometra | 4 |
Hyperplasia, Cystic | 2 |
Cervix, Abscess | 2 |
Cervix, Cyst | X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 6| 6| 6| 7| 5| 5| 7| 7| 7| 1| 2| 7| 7| 7|
DAY ON TEST | 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 2| 8| 9| 3| 6| 8| 3| 3| 3| 7| 1| 3| 3| 3|
| 7| 9| 9| 9| 9| 5| 9| 9| 9| 9| 7| 6| 6| 2| 0| 7| 9| 0| 0| 0| 8| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 4 |
Hemorrhage, Focal | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + M + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Galactocele | X |
Duct, Cyst | X X X X X X X X X X X X X X X X X X X X X X|
Duct, Inflammation, Acute, | |
Suppurative | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Focal, Subacute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 |
Hemorrhage, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Foreign Body | 3 3 |
Granuloma, Multiple | 2 2 2 2 2 1 1 1|
Infiltration Cellular, Multifocal, | |
Histiocyte | 2 2 3 2 1 |
Pigmentation, Multifocal, Cholesterol| 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Foreign Body | 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 6| 6| 6| 7| 5| 5| 7| 7| 7| 1| 2| 7| 7| 7|
DAY ON TEST | 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 2| 8| 9| 3| 6| 8| 3| 3| 3| 7| 1| 3| 3| 3|
| 7| 9| 9| 9| 9| 5| 9| 9| 9| 9| 7| 6| 6| 2| 0| 7| 9| 0| 0| 0| 8| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | 2 2 |
Nasolacrimal Duct, Inflammation, | |
Subacute | 2 1 1 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
Hemorrhage | 4 |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 1 2 1 1 1 2 1 3 2 1 1 2|
Medulla, Inflammation, Acute, | |
Suppurative | 4 |
Papilla, Necrosis | 4 |
Renal Tubule, Mineralization, | |
Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 1| 6| 6| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 8| 0| 0| 9| 3| 9| 0| 3| 3| 3| 3| 9| 3| 3| 3| 7| 3| 4| 3| 3| 7| 3| 3| 3| 3| |
| 5| 5| 6| 7| 1| 2| 3| 1| 1| 1| 7| 0| 1| 1| 1| 7| 1| 5| 2| 2| 1| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 2| 3 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 39 |
Clear Cell Focus | X X X X | 8 |
Fatty Change | 2 | 1 2.0|
Granuloma, Multiple | 2 1 1 2 1 | 11 1.3|
Hepatodiaphragmatic Nodule | 2 | 3 2.0|
Hyperplasia, Focal | 2 3 | 2 2.5|
Necrosis, Focal | | 2 1.5|
Bile Duct, Hyperplasia | 1 2 1 1 1 3 2 2 2 2 1 1 1 2 3 3 | 34 1.6|
Centrilobular, Necrosis | 2 2 1 1 | 10 1.5|
Hepatocyte, Cytomegaly | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Fat, Necrosis, Focal | 3 3 3 3 | 6 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy, Focal | 1 1| 2 1.0|
Acinus, Atrophy, Multifocal | 2 1 2 2 1 | 9 1.7|
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.0|
Inflammation, Subacute | 2 | 2 2.5|
Ulcer | 3 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | 2 | 1 2.0|
Mineralization | 2 1 1 1 2 1 2 | 9 1.3|
Ulcer | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 1| 6| 6| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 8| 0| 0| 9| 3| 9| 0| 3| 3| 3| 3| 9| 3| 3| 3| 7| 3| 4| 3| 3| 7| 3| 3| 3| 3| |
| 5| 5| 6| 7| 1| 2| 3| 1| 1| 1| 7| 0| 1| 1| 1| 7| 1| 5| 2| 2| 1| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 2 2 2 1 1 1 | 16 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Focal Cellular Change | X X X X| 7 |
Hyperplasia | 2 | 1 2.0|
Hypertrophy, Focal | | 1 1.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Focal | 2 2 | 4 1.8|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 4 3 4 2 2 3 4 3 4 3 2 3 3 4| 27 2.9|
Pars Distalis, Cyst | X X X X X X X X X X | 24 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 | 12 2.1|
Pars Distalis, Hyperplasia | 2 | 1 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 2 2 2 2 2 2 2 2 2| 18 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia, Focal | 1 1 1 1 1 2 2| 11 1.3|
Follicle, Cyst | X | 1 |
Follicular Cell, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Suppurative | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 1| 6| 6| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 8| 0| 0| 9| 3| 9| 0| 3| 3| 3| 3| 9| 3| 3| 3| 7| 3| 4| 3| 3| 7| 3| 3| 3| 3| |
| 5| 5| 6| 7| 1| 2| 3| 1| 1| 1| 7| 0| 1| 1| 1| 7| 1| 5| 2| 2| 1| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Subacute | 3 | 1 3.0|
Duct, Cyst | X X | 3 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 7 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Hydrometra | | 1 4.0|
Hyperplasia, Cystic | | 1 2.0|
Cervix, Abscess | | 1 2.0|
Cervix, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 3 3 | 4 3.0|
Hemorrhage, Focal | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Galactocele | | 1 |
Duct, Cyst | X X X X X X X X X X X X X X X X X X X X X X| 44 |
Duct, Inflammation, Acute, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
Inflammation, Focal, Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 1| 6| 6| 7| 7| 5| 7| 7| 7| 7| |
DAY ON TEST | 8| 0| 0| 9| 3| 9| 0| 3| 3| 3| 3| 9| 3| 3| 3| 7| 3| 4| 3| 3| 7| 3| 3| 3| 3| |
| 5| 5| 6| 7| 1| 2| 3| 1| 1| 1| 7| 0| 1| 1| 1| 7| 1| 5| 2| 2| 1| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 2 3 2 | 7 2.6|
Hemorrhage, Multifocal | 3 | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 3 2 3 | 6 2.3|
Foreign Body | 3 2 4 | 5 3.0|
Granuloma, Multiple | 1 1 2 1 2 2 1 1| 16 1.5|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 2 | 6 2.0|
Pigmentation, Multifocal, Cholesterol| 2 | 4 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Foreign Body | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | 2 2 1| 8 1.6|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cataract | 3 3 | 2 3.0|
Hemorrhage | | 1 4.0|
Retina, Degeneration | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 2 2 3 1 4 1 1 1 1 3 1 1 1 2 | 28 1.6|
Medulla, Inflammation, Acute, | | |
Suppurative | | 1 4.0|
Papilla, Necrosis | | 1 4.0|
Renal Tubule, Mineralization, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute, Suppurative | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 2| 2| 6| 7| 7| 3| 7| 7| 7| 7| 3| 6| 7| 7| 7| 2| 5| 6| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 9| 9| 5| 3| 3| 7| 1| 2| 3| 3| 2| 2| 0| 2| 3| 9| 6| 9| 3| 3| 4| 5| 3| 3| 3|
| 7| 7| 4| 0| 0| 4| 7| 9| 0| 0| 7| 7| 8| 9| 0| 7| 4| 8| 0| 0| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
60 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + M + A + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + M + M + + + + + + + + + + + + + + + + A + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X|
Fatty Change, Diffuse | 2 |
Granuloma, Multiple | 1 1 1 1 1 1 2 2 2 |
Hematopoietic Cell Proliferation | 1 1 |
Hepatodiaphragmatic Nodule | 2 2 |
Hyperplasia, Focal | 3 |
Mixed Cell Focus | X |
Necrosis, Focal | 1 |
Necrosis, Multifocal | 2 |
Bile Duct, Hyperplasia | 1 1 1 2 1 1 2 1 2 1 2 1 1|
Centrilobular, Fatty Change | 2 |
Centrilobular, Necrosis | 3 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Hemorrhage | |
Fat, Necrosis, Focal | 4 3 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +|
Acinus, Atrophy, Multifocal | 1 2 2 1 |
Acinus, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + +|
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia | 1 2 |
Inflammation, Subacute | 1 2 |
Mineralization | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 2| 2| 6| 7| 7| 3| 7| 7| 7| 7| 3| 6| 7| 7| 7| 2| 5| 6| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 9| 9| 5| 3| 3| 7| 1| 2| 3| 3| 2| 2| 0| 2| 3| 9| 6| 9| 3| 3| 4| 5| 3| 3| 3|
| 7| 7| 4| 0| 0| 4| 7| 9| 0| 0| 7| 7| 8| 9| 0| 7| 4| 8| 0| 0| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
60 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 2 1 1 1 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 2 1 1 2 2 3 1 2|
Valve, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X X X X X |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Focal | 1 |
Capsule, Accessory Adrenal Cortical | |
Nodule | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 3 1 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Pars Distalis, Angiectasis | 2 2 2 4 2 3 2 4 2 3|
Pars Distalis, Cyst | X X X X X X X X X X X X |
Pars Distalis, Hyperplasia, Focal | 3 2 2 2 4 2 2 2 2 3 2 |
Pars Distalis, Hyperplasia | |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia, Focal | 1 1 1 2 2 1 2 1|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Duct, Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X|
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 2| 2| 6| 7| 7| 3| 7| 7| 7| 7| 3| 6| 7| 7| 7| 2| 5| 6| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 9| 9| 5| 3| 3| 7| 1| 2| 3| 3| 2| 2| 0| 2| 3| 9| 6| 9| 3| 3| 4| 5| 3| 3| 3|
| 7| 7| 4| 0| 0| 4| 7| 9| 0| 0| 7| 7| 8| 9| 0| 7| 4| 8| 0| 0| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
60 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | 2 3 |
Hydrometra | |
Prolapse | 3 |
Cervix, Abscess | |
Cervix, Cyst | |
Cervix, Hypertrophy | 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Anemia | 2 |
Polychromasia | 2 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Ectasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 4 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 2 |
Duct, Cyst | X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 2 |
Femur, Osteopetrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 |
Hemorrhage, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 3 2 3 3 2 3 |
Foreign Body | 3 3 3 3 3 3 3 |
Granuloma, Multiple | 2 1 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 2| 2| 6| 7| 7| 3| 7| 7| 7| 7| 3| 6| 7| 7| 7| 2| 5| 6| 7| 7| 4| 6| 7| 7| 7|
DAY ON TEST | 9| 9| 5| 3| 3| 7| 1| 2| 3| 3| 2| 2| 0| 2| 3| 9| 6| 9| 3| 3| 4| 5| 3| 3| 3|
| 7| 7| 4| 0| 0| 4| 7| 9| 0| 0| 7| 7| 8| 9| 0| 7| 4| 8| 0| 0| 0| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
60 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Multifocal, | |
Histiocyte | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Subacute | 2 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Cataract | 4|
Retina, Degeneration | 4|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 2 2 1 3 2 2 1 1 1 2 1 3 1 1 3|
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 2| 3| 3| 7| 7| 2| 5| 7| 6| 6| 2| 4| 5| 6| 6| 1| 5| 6| 7| 7| |
DAY ON TEST | 6| 0| 6| 0| 3| 9| 2| 7| 2| 2| 6| 6| 3| 0| 3| 6| 3| 6| 9| 9| 6| 5| 9| 3| 3| |
| 6| 9| 2| 9| 0| 7| 7| 8| 9| 9| 7| 4| 0| 2| 2| 7| 8| 1| 4| 4| 1| 7| 8| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
60 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 2 | 2 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X | 40 |
Clear Cell Focus | X X X X X X | 14 |
Fatty Change, Diffuse | | 1 2.0|
Granuloma, Multiple | 2 1 1 2 | 13 1.4|
Hematopoietic Cell Proliferation | | 2 1.0|
Hepatodiaphragmatic Nodule | 2 2 2 | 5 2.0|
Hyperplasia, Focal | 3 | 2 3.0|
Mixed Cell Focus | X | 2 |
Necrosis, Focal | | 1 1.0|
Necrosis, Multifocal | | 1 2.0|
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 2 1 2 2| 24 1.3|
Centrilobular, Fatty Change | | 1 2.0|
Centrilobular, Necrosis | 2 1| 4 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 11 |
Hemorrhage | 3 | 1 3.0|
Fat, Necrosis, Focal | 3 | 6 3.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Acinus, Atrophy, Multifocal | | 4 1.5|
Acinus, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 1 2.0|
Hyperplasia | 2 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 2| 3| 3| 7| 7| 2| 5| 7| 6| 6| 2| 4| 5| 6| 6| 1| 5| 6| 7| 7| |
DAY ON TEST | 6| 0| 6| 0| 3| 9| 2| 7| 2| 2| 6| 6| 3| 0| 3| 6| 3| 6| 9| 9| 6| 5| 9| 3| 3| |
| 6| 9| 2| 9| 0| 7| 7| 8| 9| 9| 7| 4| 0| 2| 2| 7| 8| 1| 4| 4| 1| 7| 8| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
60 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Subacute | | 2 1.5|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 3 | 1 3.0|
Inflammation, Subacute | | 1 2.0|
Mineralization | 1 | 5 1.2|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 2 2 | 18 1.5|
Valve, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Focal Cellular Change | | 5 |
Hematopoietic Cell Proliferation | 2 | 3 2.0|
Hyperplasia, Focal | 1 | 2 1.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 | 7 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + M + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 2.0|
Pars Distalis, Angiectasis | 4 3 3 2 2 4 2 2 3| 19 2.7|
Pars Distalis, Cyst | X X X X X X X X X X | 22 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 1 2 | 17 2.2|
Pars Distalis, Hyperplasia | 2 | 1 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 1 | 7 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia, Focal | 2 2 1 | 11 1.5|
Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 2| 3| 3| 7| 7| 2| 5| 7| 6| 6| 2| 4| 5| 6| 6| 1| 5| 6| 7| 7| |
DAY ON TEST | 6| 0| 6| 0| 3| 9| 2| 7| 2| 2| 6| 6| 3| 0| 3| 6| 3| 6| 9| 9| 6| 5| 9| 3| 3| |
| 6| 9| 2| 9| 0| 7| 7| 8| 9| 9| 7| 4| 0| 2| 2| 7| 8| 1| 4| 4| 1| 7| 8| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
60 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M M + + + + + + + + + + M + + + + + + + + + + + +| 47 |
Inflammation, Subacute | 2 | 1 2.0|
Duct, Cyst | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X | 7 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Cyst | X | 1 |
Hemorrhage | | 2 2.5|
Hydrometra | 2 | 1 2.0|
Prolapse | | 1 3.0|
Cervix, Abscess | 2 | 1 2.0|
Cervix, Cyst | X | 1 |
Cervix, Hypertrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
Anemia | | 1 2.0|
Polychromasia | | 1 2.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 | 4 2.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | | 1 2.0|
Duct, Cyst | X X X X X X X X X X X X X X| 29 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | 2 | 2 2.0|
Femur, Osteopetrosis | 2 2 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 7| 2| 3| 3| 7| 7| 2| 5| 7| 6| 6| 2| 4| 5| 6| 6| 1| 5| 6| 7| 7| |
DAY ON TEST | 6| 0| 6| 0| 3| 9| 2| 7| 2| 2| 6| 6| 3| 0| 3| 6| 3| 6| 9| 9| 6| 5| 9| 3| 3| |
| 6| 9| 2| 9| 0| 7| 7| 8| 9| 9| 7| 4| 0| 2| 2| 7| 8| 1| 4| 4| 1| 7| 8| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
60 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Compression | 4 | 3 3.7|
Hemorrhage, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 2 3 3 2 2 3 2 2 3 2 2 3 2 2 | 23 2.5|
Foreign Body | 2 2 3 3 3 3 2 3 1 4 2 2 | 19 2.7|
Granuloma, Multiple | 1 3 1 | 5 1.6|
Infiltration Cellular, Multifocal, | | |
Histiocyte | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Inflammation, | | |
Subacute | 1 2 2 | 6 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | 2 | 2 3.0|
Retina, Degeneration | 2 | 2 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 2 1 1 1 1 2 1 3 1 1 1 3| 29 1.6|
Cortex, Cyst | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 4| 5| 6| 7| 6| 7| 7| 7| 7| 3| 3| 6| 6| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 4| 5| 9| 3| 3| 6| 0| 3| 3| 3| 5| 8| 1| 6| 3| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 6| 9| 9| 3| 1| 8| 0| 1| 1| 1| 4| 8| 8| 1| 1| 1| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X|
Degeneration, Cystic | |
Eosinophilic Focus | |
Fatty Change, Diffuse | |
Fatty Change, Focal | |
Granuloma, Multiple | 1 1 1 1 2 1 1 2 2 2 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | 3 2 |
Hyperplasia, Focal | 3 |
Necrosis, Multifocal | |
Vacuolization Cytoplasmic, Focal | |
Bile Duct, Hyperplasia | 2 1 1 1 2 1 1 2 1 2 1 1 1 2 |
Centrilobular, Fatty Change | 2 |
Centrilobular, Necrosis | 1 1 2 3 1 |
__________________________________________________________________________|
Mesentery | + + + +|
Fat, Necrosis, Focal | 3 3 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 4 1 2 |
Acinus, Atrophy, Multifocal | 1 3 |
Acinus, Basophilic Focus | X|
Acinus, Hyperplasia, Focal | 2 2 |
Acinus, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 4| 5| 6| 7| 6| 7| 7| 7| 7| 3| 3| 6| 6| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 4| 5| 9| 3| 3| 6| 0| 3| 3| 3| 5| 8| 1| 6| 3| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 6| 9| 9| 3| 1| 8| 0| 1| 1| 1| 4| 8| 8| 1| 1| 1| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hyperplasia | 2 |
Inflammation, Subacute | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Erosion, Multiple | 1 |
Inflammation, Subacute | |
Mineralization | 2 1 1 3 1 1 1 |
Ulcer | |
__________________________________________________________________________|
Tongue | + |
Foreign Body | |
Granuloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 2 1 2 2 1 1 1|
Inflammation, Chronic, Multifocal | 3 |
Mineralization, Multifocal | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X X X |
Inflammation, Granulomatous | 2 |
Mineralization, Multifocal | 3 |
Necrosis, Multifocal | 3 |
Capsule, Accessory Adrenal Cortical | |
Nodule | 2 X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 3 4 4 4 2 2 4 4 3 3 3 |
Pars Distalis, Cyst | X X X X X X|
Pars Distalis, Hyperplasia, Focal | 2 2 1 3 2 3|
Pars Distalis, Hyperplasia | 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 1 2 2 1 2 1 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 4| 5| 6| 7| 6| 7| 7| 7| 7| 3| 3| 6| 6| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 4| 5| 9| 3| 3| 6| 0| 3| 3| 3| 5| 8| 1| 6| 3| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 6| 9| 9| 3| 1| 8| 0| 1| 1| 1| 4| 8| 8| 1| 1| 1| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Hyperplasia, Focal | 1 1 1 1 1 1 1 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Inflammation, Acute, Suppurative | |
Inflammation, Subacute | |
Duct, Cyst | X X X |
Duct, Cyst, Multiple | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X|
Fibrosis | 2 |
Hemorrhage | 2 |
Neovascularization | |
Pigmentation, Hemosiderin | |
Cervix, Hypertrophy | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + A + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 |
Hematopoietic Cell Proliferation | 2 2 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Abscess | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 4| 5| 6| 7| 6| 7| 7| 7| 7| 3| 3| 6| 6| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 4| 5| 9| 3| 3| 6| 0| 3| 3| 3| 5| 8| 1| 6| 3| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 6| 9| 9| 3| 1| 8| 0| 1| 1| 1| 4| 8| 8| 1| 1| 1| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
Cranium, Osteopetrosis | |
Femur, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 1 1 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 3 |
Foreign Body | 2 1 1 |
Granuloma, Multiple | 2 1 1 1 1 1 1 1|
Hemorrhage, Multifocal | |
Infiltration Cellular, Multifocal, | |
Histiocyte | 3 1 |
Mineralization | 4 |
Pigmentation, Multifocal, Cholesterol| |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Inflammation, Acute, Suppurative | 2 |
Nasolacrimal Duct, Cyst | |
Nasolacrimal Duct, Foreign Body | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | 2 |
Nasolacrimal Duct, Inflammation, | |
Subacute | 1 3 2 2 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Nephropathy, Chronic | 1 1 1 2 1 2 2 1 2 2 2 2 2 2 1 2 1|
Cortex, Cyst | X |
Renal Tubule, Dilatation, Multifocal | 3 |
Renal Tubule, Mineralization, Focal | 1 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 4| 5| 6| 7| 6| 7| 7| 7| 7| 3| 3| 6| 6| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 4| 5| 9| 3| 3| 6| 0| 3| 3| 3| 5| 8| 1| 6| 3| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 6| 9| 9| 3| 1| 8| 0| 1| 1| 1| 4| 8| 8| 1| 1| 1| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Mineralization, | |
Multifocal | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 5| 3| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 1| 0| 3| 3| 3| 3| 3| 3| 3| |
| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 1| 5| 5| 5| 5| 5| 0| 9| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Parasite Metazoan | 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 2 2 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 2 | 2 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| 45 |
Clear Cell Focus | X X X X X X| 10 |
Degeneration, Cystic | 1 | 1 1.0|
Eosinophilic Focus | X | 1 |
Fatty Change, Diffuse | 2 2 | 2 2.0|
Fatty Change, Focal | 2 | 1 2.0|
Granuloma, Multiple | 1 1 1 1 1 1 1 2 1 1 1 1| 22 1.2|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | 2 2 | 4 2.3|
Hyperplasia, Focal | | 1 3.0|
Necrosis, Multifocal | 2 | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 2 1 1 1 3 1 2 3 1 2 1 1 1| 28 1.4|
Centrilobular, Fatty Change | 3 | 2 2.5|
Centrilobular, Necrosis | 1 1 2 1 | 9 1.4|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 10 |
Fat, Necrosis, Focal | 2 3 3 3 3 3 | 10 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy, Focal | 2 1| 5 2.0|
Acinus, Atrophy, Multifocal | 1 1 2 2 | 6 1.7|
Acinus, Basophilic Focus | | 1 |
Acinus, Hyperplasia, Focal | | 2 2.0|
Acinus, Hyperplasia, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 5| 3| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 1| 0| 3| 3| 3| 3| 3| 3| 3| |
| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 1| 5| 5| 5| 5| 5| 0| 9| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 2.0|
Hyperplasia | 2 3 3 | 4 2.5|
Inflammation, Subacute | 3 3 | 3 3.0|
Ulcer | 4 3 3 | 4 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 3 | 1 3.0|
Erosion, Multiple | | 1 1.0|
Inflammation, Subacute | 1 | 1 1.0|
Mineralization | 2 2 | 9 1.6|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + | 2 |
Foreign Body | 2 | 1 2.0|
Granuloma | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 1 1 2 2 2 1 1 2| 24 1.4|
Inflammation, Chronic, Multifocal | | 1 3.0|
Mineralization, Multifocal | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Focal Cellular Change | X X X X X X | 9 |
Inflammation, Granulomatous | | 1 2.0|
Mineralization, Multifocal | | 1 3.0|
Necrosis, Multifocal | | 1 3.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | 2 | 5 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 5| 3| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 1| 0| 3| 3| 3| 3| 3| 3| 3| |
| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 1| 5| 5| 5| 5| 5| 0| 9| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 4 4 4 4 3 2 2 3 3 3 3 3 2 4 3 3| 30 3.1|
Pars Distalis, Cyst | X X X X X X X X X X | 16 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 4 | 10 2.3|
Pars Distalis, Hyperplasia | | 1 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 1 1 1 2 2 2 1 1 2 2 2 2 2| 22 1.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 2 | 1 2.0|
C-Cell, Hyperplasia, Focal | 2 1 2 2 1 2 2 | 15 1.4|
Follicle, Cyst | X X X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute, Suppurative | 3 2| 2 2.5|
Inflammation, Subacute | 2 2 2 | 3 2.0|
Duct, Cyst | X X| 5 |
Duct, Cyst, Multiple | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X | 8 |
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Fibrosis | | 1 2.0|
Hemorrhage | | 1 2.0|
Neovascularization | 3 | 1 3.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Cervix, Hypertrophy | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + M + + + M + + +| 47 |
Hyperplasia | 2 | 6 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 5| 3| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 1| 0| 3| 3| 3| 3| 3| 3| 3| |
| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 1| 5| 5| 5| 5| 5| 0| 9| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 4 2.3|
Hematopoietic Cell Proliferation | 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + M + +| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Cyst | X X X X X X X X X X X X X X X X X X X X X X X| 39 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Abscess | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 3.0|
Cranium, Osteopetrosis | 3 2 | 2 2.5|
Femur, Osteopetrosis | 3 2 1 | 3 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 1 2 3 2 | 8 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 3 | 6 2.5|
Foreign Body | 2 | 4 1.5|
Granuloma, Multiple | 2 1 1 2 2 2 1 | 15 1.3|
Hemorrhage, Multifocal | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 1 2 2 1 | 6 1.7|
Mineralization | | 1 4.0|
Pigmentation, Multifocal, Cholesterol| 1 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | | 1 2.0|
Inflammation, Acute, Suppurative | 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 5| 3| 3| 3| 6| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 1| 0| 3| 3| 3| 3| 3| 3| 3| |
| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 1| 5| 5| 5| 5| 5| 0| 9| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Cyst | X | 1 |
Nasolacrimal Duct, Foreign Body | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | 2 | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | 2 2 1 1 2| 12 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 4 |
Cataract | 3 2 2 | 4 2.5|
Retina, Degeneration | 2 2 2 | 4 2.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | | 1 3.0|
Nephropathy, Chronic | 1 2 1 1 3 1 1 1 1 1 1 1 2 2 4 2 2 3 1 2 2 2| 39 1.6|
Cortex, Cyst | | 1 |
Renal Tubule, Dilatation, Multifocal | | 1 3.0|
Renal Tubule, Mineralization, Focal | | 1 1.0|
Renal Tubule, Mineralization, | | |
Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 2| 4| 5| 7| 7| 4| 4| 7| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 6| 5| 8| 2| 2| 4| 4| 2| 2| 2| 9| 5| 2| 2| 2| 2| 2| 2| 2| 2| 5| 3| 3| 3| 3|
| 7| 1| 3| 9| 9| 4| 8| 9| 9| 9| 2| 4| 9| 9| 9| 9| 9| 9| 9| 9| 4| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X|
Degeneration, Cystic, Focal | 1 |
Degeneration, Cystic | 1 2 1|
Granuloma, Multiple | 1 |
Hepatodiaphragmatic Nodule | 2 2 2 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2 2 2 1 2 1|
Centrilobular, Fatty Change | 2 1 1 2 |
Centrilobular, Necrosis | |
Centrilobular, Necrosis, Multifocal | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 1 1 1 2 1 |
Acinus, Atrophy, Multifocal | 2 2 2 2|
Acinus, Hyperplasia, Focal | 1 2 |
Acinus, Hyperplasia, Multifocal | 3|
__________________________________________________________________________|
Salivary Glands | + + + + + M + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia | |
Inflammation, Subacute | 3 |
Ulcer, Multiple | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Mineralization | 2 2 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 2| 4| 5| 7| 7| 4| 4| 7| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 6| 5| 8| 2| 2| 4| 4| 2| 2| 2| 9| 5| 2| 2| 2| 2| 2| 2| 2| 2| 5| 3| 3| 3| 3|
| 7| 1| 3| 9| 9| 4| 8| 9| 9| 9| 2| 4| 9| 9| 9| 9| 9| 9| 9| 9| 4| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 1 2 1 2 2 1 2 1 2 1 2 1 1 2 1 1|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X X X|
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 1 |
Hypertrophy, Focal | 1 |
Capsule, Accessory Adrenal Cortical | |
Nodule | X 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 2 2 2 4 4 4 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 3 2 2 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia, Focal | 1 |
C-Cell, Hyperplasia, Multifocal | 2 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Acute, Suppurative | 2 |
Inflammation, Focal, Granulomatous | |
Inflammation, Granulomatous | 2 1 1 |
Inflammation, Subacute | 2 2|
Duct, Cyst | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 2| 4| 5| 7| 7| 4| 4| 7| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 6| 5| 8| 2| 2| 4| 4| 2| 2| 2| 9| 5| 2| 2| 2| 2| 2| 2| 2| 2| 5| 3| 3| 3| 3|
| 7| 1| 3| 9| 9| 4| 8| 9| 9| 9| 2| 4| 9| 9| 9| 9| 9| 9| 9| 9| 4| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 2 1 2 2 2 1 2 1 3 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + M M + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Acute, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Anemia | 2 3 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Ectasia | 3 |
Inguinal, Inflammation, Acute, | |
Suppurative | 2 |
Mediastinal, Congestion | 3 |
Pancreatic, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 1 2 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + M + + + + +|
Congestion | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | 2 3 2 4 |
Hemorrhage | |
__________________________________________________________________________|
Thymus | + M + M + M + + + + + + M + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + M + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | X X X X X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 3 3 |
Hemorrhage, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 2| 4| 5| 7| 7| 4| 4| 7| 7| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 6| 5| 8| 2| 2| 4| 4| 2| 2| 2| 9| 5| 2| 2| 2| 2| 2| 2| 2| 2| 5| 3| 3| 3| 3|
| 7| 1| 3| 9| 9| 4| 8| 9| 9| 9| 2| 4| 9| 9| 9| 9| 9| 9| 9| 9| 4| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 3 |
Foreign Body | 3 1 3 |
Granuloma, Multiple | 2 2 2 1|
Infiltration Cellular, Multifocal, | |
Histiocyte | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 2 3|
Fungus | 3 3 4 3 3 3 3 3 3|
Inflammation, Acute, Suppurative | 2 2 3 3 3 3 2 2 3|
Mucosa, Hyperkeratosis, Focal | 2 |
Mucosa, Hyperplasia, Focal | 2 |
Nasolacrimal Duct, Foreign Body | |
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Subacute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Cataract | 4 |
Retina, Degeneration | 2 4 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 2 4 1 3 3 3 3 4 4 3 3 4 3 2 1 3 3 2 3 3|
Cortex, Cyst | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 3| 7| 5| 5| 6| 3| 3| 5| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 7| 3| 1| 6| 9| 4| 9| 1| 3| 3| 9| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 0| 3| 3| 3| |
| 1| 1| 7| 4| 7| 0| 8| 7| 1| 1| 5| 1| 1| 1| 1| 4| 2| 2| 2| 2| 0| 3| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Parasite Metazoan | 2 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + M M + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Multifocal | | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X| 37 |
Clear Cell Focus | X X X X X X X X X X X X | 21 |
Degeneration, Cystic, Focal | | 1 1.0|
Degeneration, Cystic | 2 1 | 5 1.4|
Granuloma, Multiple | 1 | 2 1.0|
Hepatodiaphragmatic Nodule | 2 | 4 2.0|
Bile Duct, Hyperplasia | 1 2 1 1 1 1 1 1 2 1 3 1 2 1 1 1 1 1 1 1 1 1 | 45 1.2|
Centrilobular, Fatty Change | 1 1 1 1 1 1 | 10 1.2|
Centrilobular, Necrosis | 3 2 | 2 2.5|
Centrilobular, Necrosis, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Fat, Necrosis, Focal | 4 | 3 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy, Focal | 1 | 6 1.2|
Acinus, Atrophy, Multifocal | 1 3 2 1 2 2 2 2 1 | 13 1.8|
Acinus, Hyperplasia, Focal | 3 2 2 2 2 3 3 2| 10 2.2|
Acinus, Hyperplasia, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
Inflammation, Subacute | 2 | 2 2.5|
Ulcer, Multiple | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 3| 7| 5| 5| 6| 3| 3| 5| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 7| 3| 1| 6| 9| 4| 9| 1| 3| 3| 9| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 0| 3| 3| 3| |
| 1| 1| 7| 4| 7| 0| 8| 7| 1| 1| 5| 1| 1| 1| 1| 4| 2| 2| 2| 2| 0| 3| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | | 1 2.0|
Mineralization | 2 1 | 5 1.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 1 1 1 1 2 2 2 1 2 2 1 1 1 1 2 2| 35 1.4|
Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Focal Cellular Change | X X X | 6 |
Hematopoietic Cell Proliferation | 2 1 | 2 1.5|
Hyperplasia, Focal | | 1 1.0|
Hypertrophy, Focal | | 1 1.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 1 1 | 6 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 3 3 2 3 | 5 2.6|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 2 2 2 2 2 2 | 16 2.5|
Pars Distalis, Cyst | X X | 3 |
Pars Distalis, Hemorrhage | 3 | 1 3.0|
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 2 2 2 | 13 2.1|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 2.0|
C-Cell, Hyperplasia, Focal | 2 2 | 3 1.7|
C-Cell, Hyperplasia, Multifocal | | 1 2.0|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 3| 7| 5| 5| 6| 3| 3| 5| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 7| 3| 1| 6| 9| 4| 9| 1| 3| 3| 9| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 0| 3| 3| 3| |
| 1| 1| 7| 4| 7| 0| 8| 7| 1| 1| 5| 1| 1| 1| 1| 4| 2| 2| 2| 2| 0| 3| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 2 | 1 2.0|
Inflammation, Acute, Suppurative | | 1 2.0|
Inflammation, Focal, Granulomatous | 2 | 1 2.0|
Inflammation, Granulomatous | 1 | 4 1.3|
Inflammation, Subacute | 2 2 2 2 | 6 2.0|
Duct, Cyst | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | 2 2 2 1 2 1 1 1 2 1 1 | 23 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + M + + + + + + + + + + + + + + + + + +| 47 |
Dilatation | 4 | 1 4.0|
Inflammation, Acute, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 3 3| 6 2.8|
Developmental Malformation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
Anemia | | 2 2.5|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Ectasia | | 1 3.0|
Inguinal, Inflammation, Acute, | | |
Suppurative | | 1 2.0|
Mediastinal, Congestion | | 1 3.0|
Pancreatic, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 2 1 1| 9 1.7|
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Congestion | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | | 1 3.0|
Hematopoietic Cell Proliferation | 3 4 2 2 2 | 9 2.7|
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 3| 7| 5| 5| 6| 3| 3| 5| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 7| 3| 1| 6| 9| 4| 9| 1| 3| 3| 9| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 0| 3| 3| 3| |
| 1| 1| 7| 4| 7| 0| 8| 7| 1| 1| 5| 1| 1| 1| 1| 4| 2| 2| 2| 2| 0| 3| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M M + + + + + + + + + +| 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + M + + + + + + + M + + + + + + + + +| 45 |
Duct, Cyst | X X X X X X X X X | 21 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 4 2.8|
Hemorrhage, Multifocal | 4 | 1 4.0|
Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 3 2 4 | 7 2.7|
Foreign Body | 2 3 1 2 | 7 2.1|
Granuloma, Multiple | 2 2 | 6 1.8|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 | 4 2.5|
Fungus | 3 4 2 3 | 13 3.1|
Inflammation, Acute, Suppurative | 3 2 2 2 | 13 2.5|
Mucosa, Hyperkeratosis, Focal | | 1 2.0|
Mucosa, Hyperplasia, Focal | | 1 2.0|
Nasolacrimal Duct, Foreign Body | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | 2 2 | 5 2.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | 2 2 1 | 4 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 3| 7| 5| 5| 6| 3| 3| 5| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| |
DAY ON TEST | 7| 3| 1| 6| 9| 4| 9| 1| 3| 3| 9| 3| 3| 3| 3| 8| 3| 3| 3| 3| 7| 0| 3| 3| 3| |
| 1| 1| 7| 4| 7| 0| 8| 7| 1| 1| 5| 1| 1| 1| 1| 4| 2| 2| 2| 2| 0| 3| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + | 4 |
Cataract | 4 | 2 4.0|
Retina, Degeneration | 4 | 3 3.3|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 3 1 2 2 4 3 1 3 2 3 4 1 3 3 3 2 2 3 3 3 4| 42 2.7|
Cortex, Cyst | X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 2| 4| 5| 7| 7| 0| 3| 5| 6| 7| 0| 5| 6| 6| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 7| 0| 2| 2| 2| 8| 8| 9| 2| 2| 8| 0| 0| 5| 2| 9| 6| 5| 7| 2| 0| 5| 0| 2| 3|
| 9| 6| 9| 9| 9| 7| 1| 7| 9| 9| 4| 9| 8| 7| 9| 9| 4| 5| 5| 9| 4| 5| 2| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
60 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + M + M + + + + + + + + + + +|
Parasite Metazoan | 2 2 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 1 |
Basophilic Focus | X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X|
Congestion | |
Degeneration, Cystic, Focal | 2 1 |
Degeneration, Cystic | 1 |
Fatty Change, Diffuse | |
Granuloma, Multiple | 1 1|
Hepatodiaphragmatic Nodule | 2 |
Bile Duct, Dysplasia, Focal | 4 |
Bile Duct, Fibrosis, Focal | 4 |
Bile Duct, Hyperplasia, Focal | |
Bile Duct, Hyperplasia | 1 1 2 1 1 3 1 1 2 1 2 2 2 2 4 3 1 2 2|
Biliary Tract, Cyst Multilocular | X |
Centrilobular, Fatty Change | |
Centrilobular, Necrosis | 3 2 2 1|
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis, Focal | 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 1 1 |
Acinus, Atrophy, Multifocal | 1 1 2 2 |
Acinus, Hyperplasia, Focal | 2 2 4 2 2 2 2|
Duct, Ectasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Subacute | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 2| 4| 5| 7| 7| 0| 3| 5| 6| 7| 0| 5| 6| 6| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 7| 0| 2| 2| 2| 8| 8| 9| 2| 2| 8| 0| 0| 5| 2| 9| 6| 5| 7| 2| 0| 5| 0| 2| 3|
| 9| 6| 9| 9| 9| 7| 1| 7| 9| 9| 4| 9| 8| 7| 9| 9| 4| 5| 5| 9| 4| 5| 2| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
60 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 2 4 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 2 2 1 2 2 1 1 2 1 2 2 2|
Congestion | |
Inflammation, Chronic, Focal | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X X |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage, Focal | |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 2 4 2 2 2 3 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 2 |
Follicle, Cyst | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 2 2 |
Inflammation, Subacute | 3 2 3 |
Duct, Cyst | X |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 2| 4| 5| 7| 7| 0| 3| 5| 6| 7| 0| 5| 6| 6| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 7| 0| 2| 2| 2| 8| 8| 9| 2| 2| 8| 0| 0| 5| 2| 9| 6| 5| 7| 2| 0| 5| 0| 2| 3|
| 9| 6| 9| 9| 9| 7| 1| 7| 9| 9| 4| 9| 8| 7| 9| 9| 4| 5| 5| 9| 4| 5| 2| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
60 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 3 2 1 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Subacute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 3 4 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Mediastinal, Ectasia | |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Pancreatic, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +|
Ectasia | 2 1 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + M + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 2 2 2 |
Necrosis, Multifocal | |
Thrombosis | |
__________________________________________________________________________|
Thymus | + + M M + + M + + + + + + + M + M + + + M + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | X X X X X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Granulomatous, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 2| 4| 5| 7| 7| 0| 3| 5| 6| 7| 0| 5| 6| 6| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 7| 0| 2| 2| 2| 8| 8| 9| 2| 2| 8| 0| 0| 5| 2| 9| 6| 5| 7| 2| 0| 5| 0| 2| 3|
| 9| 6| 9| 9| 9| 7| 1| 7| 9| 9| 4| 9| 8| 7| 9| 9| 4| 5| 5| 9| 4| 5| 2| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
60 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Fungus | |
Hemorrhage, Multifocal | 3 |
Inflammation, Acute, Suppurative | |
Necrosis | |
Thrombosis, Multiple | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 4 3 3 2 |
Foreign Body | 2 2 4 2 2 |
Fungus | |
Infiltration Cellular, Multifocal, | |
Histiocyte | |
Inflammation, Acute, Focal, | |
Suppurative | |
Necrosis, Multifocal | |
Thrombosis, Multiple | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Mediastinum, Foreign Body | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Fungus | 3 3 3 3 2 2 |
Inflammation, Acute, Suppurative | 2 2 2 2 2 2 |
Nasolacrimal Duct, Cyst | X |
Nasolacrimal Duct, Foreign Body | |
Nasolacrimal Duct, Inflammation, | |
Subacute | 2 2 |
Nasopharyngeal Duct, Foreign Body | 2 |
Nasopharyngeal Duct, Inflammation, | |
Subacute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 1 |
Nephropathy, Chronic | 2 2 3 3 4 2 4 3 2 1 4 3 3 4 3 3 3 2 3 3|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 2| 4| 5| 7| 7| 0| 3| 5| 6| 7| 0| 5| 6| 6| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 7| 0| 2| 2| 2| 8| 8| 9| 2| 2| 8| 0| 0| 5| 2| 9| 6| 5| 7| 2| 0| 5| 0| 2| 3|
| 9| 6| 9| 9| 9| 7| 1| 7| 9| 9| 4| 9| 8| 7| 9| 9| 4| 5| 5| 9| 4| 5| 2| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
60 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Pigmentation, | |
Hemosiderin, Multifocal | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 5| 5| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 0| 3| 3| 3| 7| 0| 3| 3| 3| 4| 6| 9| 7| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 8| 0| 0| 0| 1| 8| 0| 0| 0| 7| 8| 9| 6| 0| 8| 9| 0| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
60 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + M + + + + + + + + + + M + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + + M + + + + +| 48 |
Parasite Metazoan | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + M + + + + + + + + + + M + + + + +| 48 |
Parasite Metazoan | 2 2 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + M M + + + + + + + + + M + + + + +| 45 |
Parasite Metazoan | 2 2 X 2 2 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + M + + + + + + + + + + M + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M + + + M + + + + + + + + + + M + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + M + + + + + + + + + + M + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + M M + + + + + + + + + M + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | | 1 1.0|
Basophilic Focus | X X X X X X X X X X X X| 26 |
Clear Cell Focus | X X X X X X| 16 |
Congestion | 2 | 1 2.0|
Degeneration, Cystic, Focal | 2 2 2 2 | 6 1.8|
Degeneration, Cystic | 1 | 2 1.0|
Fatty Change, Diffuse | 2 2 | 2 2.0|
Granuloma, Multiple | 1 | 3 1.0|
Hepatodiaphragmatic Nodule | | 1 2.0|
Bile Duct, Dysplasia, Focal | 4 | 2 4.0|
Bile Duct, Fibrosis, Focal | 4 | 2 4.0|
Bile Duct, Hyperplasia, Focal | 4 | 1 4.0|
Bile Duct, Hyperplasia | 2 2 2 1 1 2 1 2 1 2 1 1 2 2 2 1 2 1 3 2 1 2 1| 42 1.7|
Biliary Tract, Cyst Multilocular | | 1 |
Centrilobular, Fatty Change | 2 1 2 | 3 1.7|
Centrilobular, Necrosis | 2 2 2 1 2 2 2 2 | 12 1.9|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 9 |
Fat, Necrosis, Focal | 4 4 3 4 | 6 3.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + M M + + + + + + + + + M + + + + +| 47 |
Acinus, Atrophy, Focal | 2 1 | 4 1.3|
Acinus, Atrophy, Multifocal | 2 2 1 1 2 2 1 1 | 12 1.5|
Acinus, Hyperplasia, Focal | 2 2 2 3 3 1 3 3 2| 16 2.3|
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + M M + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 5| 5| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 0| 3| 3| 3| 7| 0| 3| 3| 3| 4| 6| 9| 7| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 8| 0| 0| 0| 1| 8| 0| 0| 0| 7| 8| 9| 6| 0| 8| 9| 0| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
60 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 2 2.0|
Inflammation, Subacute | 2 | 2 2.5|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 2.0|
Mineralization | 1 3 1 | 6 2.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
Aorta, Mineralization | 2 | 2 2.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 2 1 2 1 2 2 1 2 2 2 2 2 2 2 1 2 2 1 2| 36 1.7|
Congestion | 3 | 1 3.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Thrombosis | 4 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + M M + + + + + + + + + M + + + + +| 47 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + M M + + + + + + + + + M + + + + +| 47 |
Focal Cellular Change | X | 3 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage, Focal | 2 | 1 2.0|
Hypertrophy, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + M M + + + + + + + + + M + + + + +| 46 |
Hyperplasia, Focal | 1 2 2 2 | 8 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + M M + + + + + + + + + M + + + + +| 47 |
Hyperplasia, Focal | | 1 2.0|
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + M| 47 |
Hyperplasia | 1 2 | 3 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 2 1 2 3 2 4 3 4 | 17 2.6|
Pars Distalis, Cyst | X| 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 1 1 2 | 12 1.8|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 2 | 6 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 1 2 | 4 1.8|
Follicle, Cyst | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 5| 5| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 0| 3| 3| 3| 7| 0| 3| 3| 3| 4| 6| 9| 7| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 8| 0| 0| 0| 1| 8| 0| 0| 0| 7| 8| 9| 6| 0| 8| 9| 0| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
60 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + M M + + + + + + + + + + + + + + +| 47 |
Inflammation, Granulomatous | 2 | 3 2.0|
Inflammation, Subacute | 2 2 | 5 2.4|
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | 1 3 1 2 3 4 3 | 18 2.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 | 1 2.0|
Inflammation, Subacute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 3 2 3 3 | 11 2.7|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + M M + + + + + + + + + + + + + + +| 48 |
Mediastinal, Congestion | 2 2 | 2 2.0|
Mediastinal, Ectasia | 2 2 | 2 2.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 2 | 1 2.0|
Pancreatic, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M M + + + + + + + + + + + + + + +| 47 |
Ectasia | 2 2 2 2| 6 1.8|
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M M + + + + + + + + + M + + + + +| 46 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis, Focal | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 5 2.0|
Necrosis, Multifocal | 2 | 1 2.0|
Thrombosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + M + M M M + + + +| 38 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M M + + + + + + + + + M + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 5| 5| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 0| 3| 3| 3| 7| 0| 3| 3| 3| 4| 6| 9| 7| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 8| 0| 0| 0| 1| 8| 0| 0| 0| 7| 8| 9| 6| 0| 8| 9| 0| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
60 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Duct, Cyst | X X X X X X X X X X X X | 24 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 | 2 2.5|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Inflammation, Granulomatous, | | |
Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X 2 | 3 2.5|
Fungus | 2 | 1 2.0|
Hemorrhage, Multifocal | 3 | 2 3.0|
Inflammation, Acute, Suppurative | 2 | 1 2.0|
Necrosis | 3 | 1 3.0|
Thrombosis, Multiple | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 2 | 9 2.7|
Foreign Body | 3 2 1 | 8 2.3|
Fungus | 4 | 1 4.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 3 | 1 3.0|
Inflammation, Acute, Focal, | | |
Suppurative | 3 3 | 2 3.0|
Necrosis, Multifocal | 3 | 1 3.0|
Thrombosis, Multiple | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 2 | 3 1.7|
Mediastinum, Foreign Body | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 2 2| 4 2.0|
Fungus | 4 4 3 3| 10 3.0|
Inflammation, Acute, Suppurative | 2 3 2 2| 10 2.1|
Nasolacrimal Duct, Cyst | | 1 |
Nasolacrimal Duct, Foreign Body | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 5| 5| 5| 6| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 0| 3| 3| 3| 7| 0| 3| 3| 3| 4| 6| 9| 7| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| |
| 2| 8| 0| 0| 0| 1| 8| 0| 0| 0| 7| 8| 9| 6| 0| 8| 9| 0| 0| 0| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
60 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Inflammation, | | |
Subacute | 1 2 2 | 5 1.8|
Nasopharyngeal Duct, Foreign Body | | 1 2.0|
Nasopharyngeal Duct, Inflammation, | | |
Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + M + | 3 |
Cataract | 2 2 4 | 3 2.7|
Retina, Degeneration | 2 2 4 | 3 2.7|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | | 1 1.0|
Nephropathy, Chronic | 3 3 3 3 4 2 3 4 3 1 2 2 2 4 2 3 3 3 3 3 3 3 2| 43 2.8|
Renal Tubule, Pigmentation, | | |
Hemosiderin, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 2| 5| 6| 7| 7| 3| 6| 7| 7| 7|
DAY ON TEST | 6| 7| 7| 3| 3| 1| 3| 2| 3| 3| 1| 0| 3| 3| 3| 7| 3| 7| 0| 3| 2| 6| 3| 3| 3|
| 1| 6| 6| 1| 1| 4| 1| 9| 1| 1| 3| 2| 1| 1| 1| 6| 6| 4| 9| 1| 9| 8| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Multiple | |
Intussusception | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X|
Degeneration, Cystic | 1 1 2 1 1 1 1 1 1|
Fatty Change, Diffuse | |
Granuloma, Multiple | 1 1 1 1 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | 2 3 2|
Hyperplasia, Focal | |
Necrosis, Multifocal | |
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 2 2 2 2|
Centrilobular, Fatty Change | 2 3 2 1 1 |
Centrilobular, Necrosis, Focal | 2 |
Centrilobular, Necrosis | 1 2 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Multifocal | 1 |
Inflammation, Multifocal, Subacute | 3 |
Acinus, Atrophy, Focal | 1 2 2 |
Acinus, Atrophy, Multifocal | 2 2 2 2 2 |
Acinus, Hyperplasia, Focal | 4 2 2 2 2 2 2 3 |
Acinus, Hyperplasia, Multifocal | 3 4 3 |
Artery, Hypertrophy | 4 |
Artery, Inflammation, Subacute | |
Artery, Mineralization | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 2| 5| 6| 7| 7| 3| 6| 7| 7| 7|
DAY ON TEST | 6| 7| 7| 3| 3| 1| 3| 2| 3| 3| 1| 0| 3| 3| 3| 7| 3| 7| 0| 3| 2| 6| 3| 3| 3|
| 1| 6| 6| 1| 1| 4| 1| 9| 1| 1| 3| 2| 1| 1| 1| 6| 6| 4| 9| 1| 9| 8| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | |
Erosion | 2 |
Hyperplasia | 2 2 |
Inflammation, Subacute | 2 2 |
Perforation | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Mineralization | 2 1 2 2 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 2 2 1 1 3 2 2 2 1 2 2 2 3 2 3|
Inflammation, Chronic, Focal | |
Mineralization, Multifocal | |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X X X|
Focal Cellular Change, Multiple | |
Capsule, Accessory Adrenal Cortical | |
Nodule | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Focal | 2 2 1 1 2 2 1 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Pars Distalis, Angiectasis | 1 3 4 3 3 3 3 2 2 2 1|
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia, Focal | 2 2 1 2 2 2 2|
Pars Distalis, Pigmentation, | |
Hematoidin | 1 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 1 2 2 2 2 1 1 1|
Pars Nervosa, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 |
C-Cell, Hyperplasia, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 2| 5| 6| 7| 7| 3| 6| 7| 7| 7|
DAY ON TEST | 6| 7| 7| 3| 3| 1| 3| 2| 3| 3| 1| 0| 3| 3| 3| 7| 3| 7| 0| 3| 2| 6| 3| 3| 3|
| 1| 6| 6| 1| 1| 4| 1| 9| 1| 1| 3| 2| 1| 1| 1| 6| 6| 4| 9| 1| 9| 8| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicle, Cyst | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 3 2 2 2 1 |
Duct, Cyst | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Suppurative | |
Inflammation, Subacute | 2 1 1 2 2 1 1 2 1 2 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Ectasia | |
Deep Cervical, Hyperplasia | |
Mediastinal, Congestion | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 1 |
Necrosis, Focal | 4 |
Necrosis, Multifocal | |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + M + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | X X X X X X X X X X X X X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal, | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 2| 5| 6| 7| 7| 3| 6| 7| 7| 7|
DAY ON TEST | 6| 7| 7| 3| 3| 1| 3| 2| 3| 3| 1| 0| 3| 3| 3| 7| 3| 7| 0| 3| 2| 6| 3| 3| 3|
| 1| 6| 6| 1| 1| 4| 1| 9| 1| 1| 3| 2| 1| 1| 1| 6| 6| 4| 9| 1| 9| 8| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hemorrhage, Multifocal | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 3 3 2 2 |
Foreign Body | 2 3 2 3 2 3 |
Granuloma, Multiple | 2 |
Hemorrhage, Multifocal | |
Infiltration Cellular, Multifocal, | |
Histiocyte | 2 |
Necrosis, Multifocal | 2 |
Pigmentation, Multifocal | |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 3 |
Fat, Mediastinum, Necrosis, | |
Multifocal | |
Mediastinum, Foreign Body | 3 |
Pleura, Fibrosis, Focal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + M + + + + + + + + +|
Foreign Body | 2 2 2 2 |
Fungus | 3 3 3 3 |
Inflammation, Acute, Suppurative | 2 2 1 3 3 |
Nasolacrimal Duct, Foreign Body | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Subacute | 1 2 2 2|
Nasopharyngeal Duct, Cyst | |
Nasopharyngeal Duct, Inflammation, | |
Subacute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7| 1| 7| 7| 7| 7| 2| 5| 6| 7| 7| 3| 6| 7| 7| 7|
DAY ON TEST | 6| 7| 7| 3| 3| 1| 3| 2| 3| 3| 1| 0| 3| 3| 3| 7| 3| 7| 0| 3| 2| 6| 3| 3| 3|
| 1| 6| 6| 1| 1| 4| 1| 9| 1| 1| 3| 2| 1| 1| 1| 6| 6| 4| 9| 1| 9| 8| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 4 2 |
Retina, Degeneration | 4 4 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Hydronephrosis | |
Inflammation, Acute, Multifocal, | |
Suppurative | |
Nephropathy, Chronic | 2 2 4 3 3 1 2 3 3 3 2 3 2 3 1 4 2 3 2 3 2 3|
Capsule, Fibrosis, Focal | |
Cortex, Cyst | 4 X |
Papilla, Necrosis | |
Pelvis, Inflammation, Acute, | |
Suppurative | |
Renal Tubule, Dilatation, Multifocal | |
Renal Tubule, Mineralization, | |
Multifocal | |
Renal Tubule, Pigmentation, | |
Hemosiderin, Multifocal | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 1| 4| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 6| 0| 3| 3| 3| 0| 8| 2| 9| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 8| 3| 3| 3| |
| 6| 8| 2| 2| 2| 1| 4| 2| 3| 2| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 2| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | 2 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Erosion, Multiple | 3 | 1 3.0|
Intussusception | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2| 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X| 35 |
Clear Cell Focus | X X X X X X X X X X| 19 |
Degeneration, Cystic | 1 1 | 11 1.1|
Fatty Change, Diffuse | 2 3 | 2 2.5|
Granuloma, Multiple | 1 1 1 | 7 1.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | X 3 | 5 2.5|
Hyperplasia, Focal | 3 | 1 3.0|
Necrosis, Multifocal | 1 | 1 1.0|
Bile Duct, Hyperplasia | 1 1 1 2 1 2 1 1 1 2 1 1 1 1 1 1 1 1 2 2| 41 1.3|
Centrilobular, Fatty Change | 2 | 6 1.8|
Centrilobular, Necrosis, Focal | | 1 2.0|
Centrilobular, Necrosis | 1 2 1 1 2 | 8 1.4|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
Fat, Necrosis, Focal | 3 2 2 | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Multifocal | | 1 1.0|
Inflammation, Multifocal, Subacute | | 1 3.0|
Acinus, Atrophy, Focal | 1 2 1 | 6 1.5|
Acinus, Atrophy, Multifocal | 2 2 2 | 8 2.0|
Acinus, Hyperplasia, Focal | 2 1 1 3 2 1 2 2 2 3 | 18 2.1|
Acinus, Hyperplasia, Multifocal | 3 2 | 5 3.0|
Artery, Hypertrophy | 4 | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 1| 4| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 6| 0| 3| 3| 3| 0| 8| 2| 9| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 8| 3| 3| 3| |
| 6| 8| 2| 2| 2| 1| 4| 2| 3| 2| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 2| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Artery, Inflammation, Subacute | 3 | 1 3.0|
Artery, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 4 3 | 2 3.5|
Erosion | | 1 2.0|
Hyperplasia | 3 2 3 | 5 2.4|
Inflammation, Subacute | 2 4 3 | 5 2.6|
Perforation | 4 4 | 2 4.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | 3 | 2 2.5|
Mineralization | 1 2 2 2 1 2 | 11 1.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 3 2 3 3 3 1 3 1 1 1 1 1| 32 1.9|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Mineralization, Multifocal | 2 | 1 2.0|
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Focal Cellular Change | X X| 5 |
Focal Cellular Change, Multiple | 2 | 1 2.0|
Capsule, Accessory Adrenal Cortical | | |
Nodule | X | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 3 4 | 2 3.5|
Hyperplasia, Focal | 2 1 2 2 3 2 2 | 14 1.8|
Pigmentation, Hemosiderin | 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 3 2 1 1 | 4 1.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 3 4 2 4 2 3 1 3 1| 20 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 1| 4| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 6| 0| 3| 3| 3| 0| 8| 2| 9| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 8| 3| 3| 3| |
| 6| 8| 2| 2| 2| 1| 4| 2| 3| 2| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 2| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Cyst | X | 4 |
Pars Distalis, Hyperplasia, Focal | 1 2 | 9 1.8|
Pars Distalis, Pigmentation, | | |
Hematoidin | 2 | 2 1.5|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 2 1 2 1 2 | 14 1.6|
Pars Nervosa, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 1 2 1 1 2 2| 7 1.4|
C-Cell, Hyperplasia, Multifocal | 2 1 | 2 1.5|
Follicle, Cyst | X X X | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | 2 2 2 2 2 3 | 11 2.1|
Duct, Cyst | X X X | 5 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Suppurative | 4 | 1 4.0|
Inflammation, Subacute | 1 2 2 2 3 2 2 2 | 19 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 | 3 3.0|
Mineralization | 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Deep Cervical, Ectasia | 3 | 1 3.0|
Deep Cervical, Hyperplasia | 3 | 1 3.0|
Mediastinal, Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 1| 4| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 6| 0| 3| 3| 3| 0| 8| 2| 9| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 8| 3| 3| 3| |
| 6| 8| 2| 2| 2| 1| 4| 2| 3| 2| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 2| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Ectasia | 3 2 | 6 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 1 2 2 | 5 1.6|
Necrosis, Focal | | 1 4.0|
Necrosis, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Duct, Cyst | X X X X X X X X X X X X X X| 27 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Focal, | | |
Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 3 2 1 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 2 | 2 2.0|
Hemorrhage, Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 2 3 | 9 2.4|
Foreign Body | 3 2 | 8 2.5|
Granuloma, Multiple | 2 | 2 2.0|
Hemorrhage, Multifocal | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 2 | 2 2.0|
Necrosis, Multifocal | | 1 2.0|
Pigmentation, Multifocal | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 1| 4| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 6| 0| 3| 3| 3| 0| 8| 2| 9| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 8| 3| 3| 3| |
| 6| 8| 2| 2| 2| 1| 4| 2| 3| 2| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 2| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Fat, Mediastinum, Necrosis, | | |
Multifocal | 1 | 1 1.0|
Mediastinum, Foreign Body | | 1 3.0|
Pleura, Fibrosis, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 2 2 2 2 2 2 | 10 2.0|
Fungus | 3 3 2 3 3 3 | 10 2.9|
Inflammation, Acute, Suppurative | 3 3 3 2 2 2 2 2 | 13 2.3|
Nasolacrimal Duct, Foreign Body | 2 | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute, Suppurative | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | 2 1 1 2 2 2 | 10 1.7|
Nasopharyngeal Duct, Cyst | X | 1 |
Nasopharyngeal Duct, Inflammation, | | |
Subacute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 2 3.0|
Retina, Degeneration | | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Developmental Malformation | X | 1 |
Hydronephrosis | 4 | 1 4.0|
Inflammation, Acute, Multifocal, | | |
Suppurative | 3 | 1 3.0|
Nephropathy, Chronic | 4 2 4 3 4 2 2 4 2 2 3 2 4 3 2 4 2 4 3 3 2| 43 2.7|
Capsule, Fibrosis, Focal | 3 | 1 3.0|
Cortex, Cyst | X | 3 4.0|
Papilla, Necrosis | 4 | 1 4.0|
Pelvis, Inflammation, Acute, | | |
Suppurative | 3 | 1 3.0|
Renal Tubule, Dilatation, Multifocal | 3 | 1 3.0|
Renal Tubule, Mineralization, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05005-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC FURFURAL Date: 04/17/97
Route: GAVAGE Time: 07:23:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 1| 4| 6| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| |
DAY ON TEST | 6| 0| 3| 3| 3| 0| 8| 2| 9| 3| 0| 3| 3| 3| 3| 8| 3| 3| 3| 3| 5| 8| 3| 3| 3| |
| 6| 8| 2| 2| 2| 1| 4| 2| 3| 2| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 2| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
30 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Multifocal | 2 | 1 2.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Suppurative | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
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