TR 382 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/03/94
EXP: 05005 FURFURAL TIME: 05:09:59
TEST: 07 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56177
CONT: NO1CP9565101 CAS: 98-01-1
PATHOLOGIST: H. GILES S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
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TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/03/94
EXP: 05005 FURFURAL TIME: 05:09:59
TEST: 07 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56177
CONT: NO1CP9565101 CAS: 98-01-1
PATHOLOGIST: H. GILES S. EUSTIS
FURFURAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 6 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 340 444 448 470 484 517 517 554 583 595 |
| 603 654 697 |
| CENSORED DEATHS |
| 267 292 371 398 451 564 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 7 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 484 514 585 622 666 668 674 676 676 682 |
| 693 702 707 708 709 |
| CENSORED DEATHS |
| 101 113 276 329 536 551 561 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 60. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 8 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 438 479 481 508 568 582 589 597 604 606 |
| 655 655 657 675 676 702 708 708 |
| CENSORED DEATHS |
| 84 99 287 309 371 547 564 599 |
| |
==================================================================================
FURFURAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 97.9 97.9 89.1 84.7 75.6 73.3 71.0 |
|CONTROL | |
| | |
|30. | 100.0 100.0 100.0 100.0 100.0 97.8 95.7 93.3 91.0 65.3 |
|MG/KG | |
| | |
|60. | 100.0 100.0 100.0 100.0 100.0 93.3 91.1 79.4 69.7 57.7 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 30. 60. |
| CONTROL MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 71.0% 65.3% 57.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.343 P=1.000 P=0.451 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 531.2 651.1 604.9 |
|NATURAL DEATHS (C) | (26.8) (18.2) (19.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 637.0 652.9 624.9 |
|(STANDARD ERROR) | (19.6) (21.3) (22.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
FURFURAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 4 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 210 217 567 571 589 592 605 605 606 626 |
| 631 637 645 686 690 692 697 703 |
| CENSORED DEATHS |
| 177 178 567 585 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 2 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 346 388 459 531 562 582 599 610 611 618 |
| 633 654 661 668 700 709 |
| CENSORED DEATHS |
| 354 465 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 60. MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 19 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 438 602 627 632 653 654 662 694 694 698 |
| 708 709 717 |
| CENSORED DEATHS |
| 161 267 267 297 297 297 297 327 327 374 |
| 378 440 466 509 557 561 564 564 698 |
| |
==================================================================================
FURFURAL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 95.8 95.8 95.8 95.8 95.8 82.9 72.0 61.1 |
|CONTROL | |
| | |
|30. | 100.0 100.0 100.0 98.0 96.0 93.9 91.8 85.6 73.0 66.8 |
|MG/KG | |
| | |
|60. | 100.0 100.0 100.0 100.0 100.0 97.4 97.4 94.3 78.6 59.3 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 30. 60. |
| CONTROL MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 61.1% 66.8% 59.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.849N P=0.741N P=0.943N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 587.2 583.2 652.9 |
|NATURAL DEATHS (C) | (33.7) (26.3) (20.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 649.8 669.6 585.2 |
|(STANDARD ERROR) | (20.7) (14.8) (24.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
FURFURAL
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
30. MG/KG = 2
60. MG/KG = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 2
|
| 1 31 32 2
| 2 2
95 +
| 1 13 3 2 2
|
| 1 1 3 3 2 2
90 +
| 1 1 3 3
P |
E | 3 3 22
R 85 + 1 1
C | 33
E | 1 1
N | 33
T 80 + 1 1
| 22
S | 1 1 3 22
U |
R 75 + 1 1 2 2
V | 1 1
I |
V | 1 1
A 70 + 3 3 22
L |
|
|
65 + 3 32 2
|
| 33
|
60 +
|
| 3 3
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.
FURFURAL
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
30. MG/KG = 2
60. MG/KG = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
|
| 11 2 2 3 3
| 1 2 2 1
95 +
| 2 2 11 3 3
|
| 2 21 1 33
90 + 2 2
|
P | 2 121 3 3
E |
R 85 + 2 2
C |
E |
N | 1221 3 3
T 80 +
| 211 3 3
S | 2 2
U |
R 75 + 2 2
V | 1 1
I | 1 22 1
V | 2 2
A 70 + 11
L | 2 2
|
| 2 2
65 + 11
| 11
| 33
| 1 1
60 +
| 3 3
|
|
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
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