TR 383 Mouse Pathology Tables
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
CORE ANIMALS
Facility: TSI Mason Research
Chemical CAS #: 81-49-2
Lock Date: 03/25/92
Cage Range: All
Reasons For Removal: 25008 Accident 25004 Dead
25003 Moribund 25006 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 8| 3| 3| 3| 9| 3| 3| 1| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 2| 5| 3| 3| 4| 2| 3| 3| 0| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|
D 71UF | 3| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 1| 4| 5| 1| 2| 3| 4| 5| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Malignant, | |
Metastatic, Uterus | X |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Malignant, | |
Metastatic, Uterus | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hepatocellular Adenoma | X X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Mesentery | + + + |
Basosquamous Tumor Malignant, | |
Metastatic, Uterus | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Malignant, | |
Metastatic, Uterus | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +|
Parotid Gland, Lymphoma Malignant | |
Mixed | X X |
Sublingual Gland, Lymphoma Malignant | |
Mixed | |
Submandibular Gland, Lymphoma | |
Malignant Mixed | X X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 8| 3| 3| 3| 9| 3| 3| 1| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 2| 5| 3| 3| 4| 2| 3| 3| 0| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|
D 71UF | 3| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 1| 4| 5| 1| 2| 3| 4| 5| 1| 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + M + M + + M M + + M + + M + + + M M M|
__________________________________________________________________________|
Pituitary Gland | + + M + M M + + + + + + + + + + + + + + + + + M +|
Pars Distalis, Adenoma | |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Follicular Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + M + + + +|
Basosquamous Tumor Malignant, | |
Metastatic, Uterus | X |
Granulosa Cell Tumor Benign | |
Hemangioma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | X|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | |
Cervix, Basosquamous Tumor Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Lymph Node | + + + + + |
Axillary, Lymphoma Malignant Mixed | |
Inguinal, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant | |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant Mixed| X X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 8| 3| 3| 3| 9| 3| 3| 1| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 2| 5| 3| 3| 4| 2| 3| 3| 0| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|
D 71UF | 3| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 1| 4| 5| 1| 2| 3| 4| 5| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Basosquamous Tumor Malignant, | |
Metastatic, Uterus | X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + M + M + + M + + + M + M + + M + M + + M M|
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Malignant, | |
Metastatic, Uterus | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Lymphoma Malignant Mixed | X X X X |
__________________________________________________________________________|
Thymus | + + I + + + + + + M + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Osteosarcoma, Metastatic, Bone | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + M M M + + + + + + M M + + M + + M M + +|
Fibroadenoma | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Hemangioma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Rib, Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | + + + |
Diaphragm, Basosquamous Tumor | |
Malignant, Metastatic, Uterus | X |
Intercostal, Lymphoma Malignant Mixed| X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Basosquamous Tumor Malignant, | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 8| 3| 3| 3| 9| 3| 3| 1| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 4| 2| 5| 3| 3| 4| 2| 3| 3| 0| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|
D 71UF | 3| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 1| 4| 5| 1| 2| 3| 4| 5| 1| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Metastatic, Uterus | X |
Lymphoma Malignant Mixed | X X |
Osteosarcoma, Metastatic, Bone | |
Mediastinum, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Nose | + + + + + + + M + + + + + + + + + + + + + + M + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | +|
__________________________________________________________________________|
Harderian Gland | +|
Adenoma | X|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X X |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 3| 3| 3| 0| 0| |
| 3| 3| 3| 3| 3| 3| 4| 6| 3| 3| 4| 4| 3| 4| 8| 3| 8| 3| 3| 3| 4| 4| 4| 6| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
UNTREATE | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| L |
D 71UF | 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basosquamous Tumor Malignant, | | |
Metastatic, Uterus | | 1 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Basosquamous Tumor Malignant, | | |
Metastatic, Uterus | | 1 |
Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + M + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | X | 1 |
Hepatocellular Adenoma | X X X | 6 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 5 |
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Basosquamous Tumor Malignant, | | |
Metastatic, Uterus | | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basosquamous Tumor Malignant, | | |
Metastatic, Uterus | | 1 |
Lymphoma Malignant Mixed | X X | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parotid Gland, Lymphoma Malignant | | |
Mixed | X | 3 |
Sublingual Gland, Lymphoma Malignant | | |
Mixed | X | 1 |
Submandibular Gland, Lymphoma | | |
Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Lymphoma Malignant Mixed | X | 1 |
Squamous Cell Papilloma | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 3| 3| 3| 0| 0| |
| 3| 3| 3| 3| 3| 3| 4| 6| 3| 3| 4| 4| 3| 4| 8| 3| 8| 3| 3| 3| 4| 4| 4| 6| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
UNTREATE | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| L |
D 71UF | 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + M M + M + + M + + + M M + + + + + +| 33 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + M M + + + + + + + + + + + + + + + + +| 43 |
Pars Distalis, Adenoma | X | 1 |
Pars Intermedia, Adenoma | X| 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 1 |
Follicular Cell, Adenoma | | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basosquamous Tumor Malignant, | | |
Metastatic, Uterus | | 1 |
Granulosa Cell Tumor Benign | X | 1 |
Hemangioma | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Leiomyoma | X | 2 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Cervix, Basosquamous Tumor Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 3| 3| 3| 0| 0| |
| 3| 3| 3| 3| 3| 3| 4| 6| 3| 3| 4| 4| 3| 4| 8| 3| 8| 3| 3| 3| 4| 4| 4| 6| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
UNTREATE | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| L |
D 71UF | 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________|____________|
Lymph Node | + + | 7 |
Axillary, Lymphoma Malignant Mixed | X | 1 |
Inguinal, Lymphoma Malignant Mixed | X | 1 |
Lumbar, Lymphoma Malignant Mixed | X | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 2 |
Pancreatic, Lymphoma Malignant Mixed | X | 2 |
Renal, Basosquamous Tumor Malignant, | | |
Metastatic, Uterus | | 1 |
Renal, Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + I + + M + M + + + M M + + M + M M + + + +| 32 |
Lymphoma Malignant Mixed | X | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Basosquamous Tumor Malignant, | | |
Metastatic, Uterus | | 1 |
Lymphoma Malignant Mixed | X X X | 6 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | | 1 |
Lymphoma Malignant Mixed | X X X | 7 |
__________________________________________________________________________|____________|
Thymus | + + + M + + + M + + + + M + + + M + M + + + M M M| 40 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 3 |
Osteosarcoma, Metastatic, Bone | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M + M M M + + M + M M M + + + M M M M + M +| 25 |
Fibroadenoma | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 2 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X| 2 |
Subcutaneous Tissue, Hemangioma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 3| 3| 3| 0| 0| |
| 3| 3| 3| 3| 3| 3| 4| 6| 3| 3| 4| 4| 3| 4| 8| 3| 8| 3| 3| 3| 4| 4| 4| 6| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
UNTREATE | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| L |
D 71UF | 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Rib, Osteosarcoma | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 4 |
Diaphragm, Basosquamous Tumor | | |
Malignant, Metastatic, Uterus | | 1 |
Intercostal, Lymphoma Malignant Mixed| X | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Meninges, Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X | 4 |
Basosquamous Tumor Malignant, | | |
Metastatic, Uterus | | 1 |
Lymphoma Malignant Mixed | X | 3 |
Osteosarcoma, Metastatic, Bone | X | 1 |
Mediastinum, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X X | 5 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 3| 3| 3| 0| 0| |
| 3| 3| 3| 3| 3| 3| 4| 6| 3| 3| 4| 4| 3| 4| 8| 3| 8| 3| 3| 3| 4| 4| 4| 6| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
UNTREATE | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| L |
D 71UF | 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X X X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3|
| 0| 0| 0| 7| 2| 0| 0| 0| 0| 2| 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 6| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 1| 2| 3| 4| 1| 2| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + M + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Carcinoma, Multiple | X X X X X X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X X X|
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Mesentery | + + + |
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant Mixed | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant Mixed | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Squamous Cell Carcinoma | X X X X X X X X|
Squamous Cell Papilloma | X X X X |
Squamous Cell Papilloma, Multiple | X|
__________________________________________________________________________|
Stomach, Glandular | + + M + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3|
| 0| 0| 0| 7| 2| 0| 0| 0| 0| 2| 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 6| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 1| 2| 3| 4| 1| 2| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + M + M + + + + + M M + M|
__________________________________________________________________________|
Pituitary Gland | + + I + + M + + + + + + + + + + I + + + + + + I +|
Pars Distalis, Adenoma | X X X |
Pars Distalis, Adenoma, Multiple | |
Pars Distalis, Lymphoma Malignant | |
Mixed | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Luteoma | |
Lymphoma Malignant Mixed | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | |
Sarcoma Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Iliac, Lymphoma Malignant Mixed | X |
Inguinal, Lymphoma Malignant Mixed | |
Mediastinal, Lymphoma Malignant Mixed| X |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3|
| 0| 0| 0| 7| 2| 0| 0| 0| 0| 2| 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 6| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 1| 2| 3| 4| 1| 2| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Squamous Cell Carcinoma,| |
Metastatic, Stomach, Forestomach| |
Pancreatic, Lymphoma Malignant Mixed | X X X |
Renal, Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + M + + + I + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + M + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + + M + + + + + M + + + M + M M + + + + + + M +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + M M M M + M + M M M M M + + + M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Fibrosarcoma, Metastatic, | |
Skin | |
Diaphragm, Squamous Cell Carcinoma, | |
Metastatic, Stomach, Forestomach| X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3|
| 0| 0| 0| 7| 2| 0| 0| 0| 0| 2| 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 6| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 1| 2| 3| 4| 1| 2| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
Pleura, Lymphoma Malignant | |
Undifferentiated Cell Type | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + M + + + + M + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X X X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 5| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 7| 7| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 5| |
| 7| 0| 0| 7| 0| 0| 6| 3| 2| 3| 0| 9| 1| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| A |
1.0% | 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| L |
71LF | 4| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + M + + + + + + + + + + + M + + + + + + + M| 45 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + M + + M + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
Hepatocellular Carcinoma | X X X X X | 10 |
Hepatocellular Carcinoma, Multiple | X X X X X X X | 13 |
Hepatocellular Adenoma | X X X| 5 |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X | 40 |
Lymphoma Malignant Mixed | X X X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X X | 3 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 9 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosarcoma, Metastatic, Skin | X | 1 |
Lymphoma Malignant Mixed | X X X | 4 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Squamous Cell Carcinoma | X X X X | 12 |
Squamous Cell Papilloma | X X X X X X X X | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 5| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 7| 7| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 5| |
| 7| 0| 0| 7| 0| 0| 6| 3| 2| 3| 0| 9| 1| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| A |
1.0% | 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| L |
71LF | 4| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Squamous Cell Papilloma, Multiple | X X X | 4 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X X | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + M + + + + + + + M M + + + + + + +| 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + I + + + + + + + + + + + + + + + + + +| 45 |
Pars Distalis, Adenoma | X X X X X | 8 |
Pars Distalis, Adenoma, Multiple | X | 1 |
Pars Distalis, Lymphoma Malignant | | |
Mixed | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Luteoma | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Polyp Stromal | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 5| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 7| 7| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 5| |
| 7| 0| 0| 7| 0| 0| 6| 3| 2| 3| 0| 9| 1| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| A |
1.0% | 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| L |
71LF | 4| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Sarcoma Stromal | X X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 12 |
Iliac, Lymphoma Malignant Mixed | | 1 |
Inguinal, Lymphoma Malignant Mixed | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| X X X | 4 |
Mediastinal, Squamous Cell Carcinoma,| | |
Metastatic, Stomach, Forestomach| X | 1 |
Pancreatic, Lymphoma Malignant Mixed | X X X | 6 |
Renal, Lymphoma Malignant Mixed | X X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + M + + + + + + +| 45 |
Lymphoma Malignant Mixed | X X X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + M + + + + + + + + + + + + + + +| 46 |
Lymphoma Malignant Mixed | X X X X X | 7 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X X X X X | 7 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________|____________|
Thymus | + + + M M + + + + + + M + + + + + M M + + M + + +| 38 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + M M M + M M M + + M + + + M M M M + +| 25 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 5| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 7| 7| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 5| |
| 7| 0| 0| 7| 0| 0| 6| 3| 2| 3| 0| 9| 1| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| A |
1.0% | 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| L |
71LF | 4| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Abdominal, Fibrosarcoma, Metastatic, | | |
Skin | X | 1 |
Diaphragm, Squamous Cell Carcinoma, | | |
Metastatic, Stomach, Forestomach| | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X X | 15 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 2 |
Lymphoma Malignant Mixed | X | 4 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
Pleura, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + M + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Adenoma | X | 2 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X X | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X X X X X X | 13 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 1| 1| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3|
| 9| 9| 9| 8| 3| 9| 9| 9| 9| 9| 3| 3| 1| 3| 9| 9| 9| 9| 0| 0| 0| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6|
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + M + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + A + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma | X X |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Carcinoma, Multiple | X X X X X X X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X|
Lymphoma Malignant Mixed | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X X X |
__________________________________________________________________________|
Mesentery | + + + + |
Lymphoma Malignant Mixed | |
Sarcoma, Metastatic, Stomach, | |
Forestomach | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Lymphoma Malignant | |
Mixed | |
Sublingual Gland, Lymphoma Malignant | |
Mixed | |
Submandibular Gland, Lymphoma | |
Malignant Mixed | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
Squamous Cell Carcinoma | X X X X X X X |
Squamous Cell Papilloma | X X X X X X |
Squamous Cell Papilloma, Multiple | X X X X X X X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 1| 1| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3|
| 9| 9| 9| 8| 3| 9| 9| 9| 9| 9| 3| 3| 1| 3| 9| 9| 9| 9| 0| 0| 0| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6|
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Sarcoma | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + M + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Squamous Cell Carcinoma, Metastatic | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + M + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M M + + M M + + + M M + M + M + + M + + M +|
__________________________________________________________________________|
Pituitary Gland | M + + + M + + + + + + + + + + + + M M + M + + + +|
Pars Distalis, Adenoma | X |
Pars Nervosa, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
__________________________________________________________________________|
Ovary | + + + M M + + + + + + + + + + M + + + + + + + + +|
Lymphoma Malignant Mixed | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X X |
__________________________________________________________________________|
Uterus | + + + A + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Vagina | + |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Axillary, Lymphoma Malignant Mixed | |
Bronchial, Lymphoma Malignant Mixed | |
Bronchial, Sarcoma, Metastatic, | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 1| 1| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3|
| 9| 9| 9| 8| 3| 9| 9| 9| 9| 9| 3| 3| 1| 3| 9| 9| 9| 9| 0| 0| 0| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6|
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Stomach, Forestomach | |
Inguinal, Lymphoma Malignant Mixed | |
Lumbar, Lymphoma Malignant Mixed | X |
Mediastinal, Lymphoma Malignant Mixed| |
Mediastinal, Squamous Cell Carcinoma,| |
Metastatic, Stomach, Forestomach| |
Pancreatic, Lymphoma Malignant Mixed | X X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + I + + + M M + M + M M + M + + M|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + M + + + + + + + + + + + M + + + + + +|
Lymphoma Malignant Mixed | X X X X |
Sarcoma, Metastatic, Stomach, | |
Forestomach | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Thymus | M + + M M M + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M M M + M M M M + + + + M M M M + M M + + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Lymphoma | |
Malignant Mixed | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Diaphragm, Squamous Cell Carcinoma, | |
Metastatic, Stomach, Forestomach| X |
Intercostal, Lymphoma Malignant Mixed| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X X|
Alveolar/Bronchiolar Adenoma, | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 1| 1| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3|
| 9| 9| 9| 8| 3| 9| 9| 9| 9| 9| 3| 3| 1| 3| 9| 9| 9| 9| 0| 0| 0| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6|
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X |
Hemangioma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + M + + + + M + + + + + + + + + + M M + + + +|
__________________________________________________________________________|
Trachea | I + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 5| 5| 5| 7| 7| 6| |
DAY ON TEST | 8| 3| 3| 3| 5| 2| 2| 2| 2| 2| 3| 3| 9| 6| 3| 3| 6| 3| 6| 9| 6| 3| 3| 2| 3| |
| 0| 0| 0| 0| 3| 9| 9| 9| 9| 9| 0| 0| 7| 2| 0| 0| 2| 0| 4| 6| 8| 8| 0| 4| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2.0% | 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| L |
71HF | 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M + + M + + + + + + + + + + + M + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + + M + M + + + + + + + + M M + + + + A + + +| 44 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + A + + +| 46 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + A + + +| 46 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + +| 46 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatoblastoma | | 2 |
Hepatocellular Carcinoma | X X X X X X X X X| 14 |
Hepatocellular Carcinoma, Multiple | X X X X X | 13 |
Hepatocellular Adenoma | X | 4 |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X X| 45 |
Lymphoma Malignant Mixed | X X | 3 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 4 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 8 |
Lymphoma Malignant Mixed | X | 1 |
Sarcoma, Metastatic, Stomach, | | |
Forestomach | X | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Lymphoma Malignant Mixed | X X | 4 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + M + + + + + + + + + + + M + + + + + M + +| 47 |
Parotid Gland, Lymphoma Malignant | | |
Mixed | X | 1 |
Sublingual Gland, Lymphoma Malignant | | |
Mixed | X | 1 |
Submandibular Gland, Lymphoma | | |
Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 5| 5| 5| 7| 7| 6| |
DAY ON TEST | 8| 3| 3| 3| 5| 2| 2| 2| 2| 2| 3| 3| 9| 6| 3| 3| 6| 3| 6| 9| 6| 3| 3| 2| 3| |
| 0| 0| 0| 0| 3| 9| 9| 9| 9| 9| 0| 0| 7| 2| 0| 0| 2| 0| 4| 6| 8| 8| 0| 4| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2.0% | 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| L |
71HF | 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Sarcoma | X | 1 |
Squamous Cell Carcinoma | X X X X| 11 |
Squamous Cell Papilloma | X X X X X X X | 13 |
Squamous Cell Papilloma, Multiple | X X X X X X | 14 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Sarcoma | X | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Mixed | X X | 2 |
Squamous Cell Carcinoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + M + M + + + M + + + + + M M + + + M + + +| 33 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + M + + + + + + + +| 43 |
Pars Distalis, Adenoma | X X X | 4 |
Pars Nervosa, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + M + + + + + + + + + + + M + + + + + + + +| 48 |
Lymphoma Malignant Mixed | X | 1 |
Follicular Cell, Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Mixed | X | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 5| 5| 5| 7| 7| 6| |
DAY ON TEST | 8| 3| 3| 3| 5| 2| 2| 2| 2| 2| 3| 3| 9| 6| 3| 3| 6| 3| 6| 9| 6| 3| 3| 2| 3| |
| 0| 0| 0| 0| 3| 9| 9| 9| 9| 9| 0| 0| 7| 2| 0| 0| 2| 0| 4| 6| 8| 8| 0| 4| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2.0% | 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| L |
71HF | 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Vagina | | 1 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 12 |
Axillary, Lymphoma Malignant Mixed | X X | 2 |
Bronchial, Lymphoma Malignant Mixed | X | 1 |
Bronchial, Sarcoma, Metastatic, | | |
Stomach, Forestomach | X | 1 |
Inguinal, Lymphoma Malignant Mixed | X | 1 |
Lumbar, Lymphoma Malignant Mixed | X X | 3 |
Mediastinal, Lymphoma Malignant Mixed| X | 1 |
Mediastinal, Squamous Cell Carcinoma,| | |
Metastatic, Stomach, Forestomach| X | 1 |
Pancreatic, Lymphoma Malignant Mixed | X X | 4 |
Renal, Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + M M I + + M + + + + I M M + M M + + M + +| 31 |
Lymphoma Malignant Mixed | X X X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + M + + + M + + + +| 44 |
Lymphoma Malignant Mixed | X X X X | 8 |
Sarcoma, Metastatic, Stomach, | | |
Forestomach | X | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X X X X | 6 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 1 |
__________________________________________________________________________|____________|
Thymus | M + + + M + + + + + M M M + M + M + M M M + + M +| 34 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + M + M M + + M M + M M + + + M M + + M M M| 20 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 5| 5| 5| 7| 7| 6| |
DAY ON TEST | 8| 3| 3| 3| 5| 2| 2| 2| 2| 2| 3| 3| 9| 6| 3| 3| 6| 3| 6| 9| 6| 3| 3| 2| 3| |
| 0| 0| 0| 0| 3| 9| 9| 9| 9| 9| 0| 0| 7| 2| 0| 0| 2| 0| 4| 6| 8| 8| 0| 4| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2.0% | 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| L |
71HF | 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Diaphragm, Squamous Cell Carcinoma, | | |
Metastatic, Stomach, Forestomach| | 1 |
Intercostal, Lymphoma Malignant Mixed| X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Adenoma | X X X X X | 12 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 1 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Hemangioma | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Nose | + M + + + + + M + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Trachea | + + + + M + + + + + + + + + + + M + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X X X X X X | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 5| 4| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 9| 3| 2| 2| 8| 9| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 1| 0| 0| 1| 2| 2| 3| 1| 0| 3| 1| 5| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6|
D 71UM | 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + A + + + + + + + +|
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + M M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Polyp Adenomatous | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Multiple | |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submandibular Gland, Lymphoma | |
Malignant Mixed | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 5| 4| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 9| 3| 2| 2| 8| 9| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 1| 0| 0| 1| 2| 2| 3| 1| 0| 3| 1| 5| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6|
D 71UM | 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M M + M M + M M M + + + M + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M M + + + + M + + M + + I + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + I + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Preputial Gland | + + + + M + + + +|
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Prostate | + + + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
Squamous Cell Carcinoma, Metastatic, | |
Preputial Gland | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Lymphoma Malignant | |
Histiocytic | X |
Sternal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node | + + + + |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant Mixed | X X |
Mediastinal, Lymphoma Malignant Mixed| X X |
Pancreatic, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + M + + M + M M + + + + + + M M M + M M + M|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 5| 4| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 9| 3| 2| 2| 8| 9| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 1| 0| 0| 1| 2| 2| 3| 1| 0| 3| 1| 5| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6|
D 71UM | 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + M M + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Thymus | + + + M M M M M + + M + + M + + + M + + + + + + +|
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M + M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Intercostal, Lymphoma Malignant Mixed| X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Carcinoma | X X |
Hepatocellular Carcinoma, Metastatic | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Histiocytic | X |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 5| 4| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 9| 3| 2| 2| 8| 9| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 1| 0| 0| 1| 2| 2| 3| 1| 0| 3| 1| 5| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6|
D 71UM | 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Fibrosarcoma | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 3| 5| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 1| 2| 1| 1| 2| 2| 2| 1| 2| 2| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
UNTREATE | 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| L |
D 71UM | 4| 5| 2| 3| 4| 5| 1| 2| 3| 5| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + + + + + + + + + + + + + M M + + +| 46 |
Lymphoma Malignant Mixed | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
Polyp Adenomatous | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma, Multiple | X X X | 3 |
Hepatocellular Carcinoma | X X X X | 8 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X | 4 |
Hepatocellular Adenoma, Multiple | X X X X X | 6 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Submandibular Gland, Lymphoma | | |
Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 3| 5| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 1| 2| 1| 1| 2| 2| 2| 1| 2| 2| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
UNTREATE | 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| L |
D 71UM | 4| 5| 2| 3| 4| 5| 1| 2| 3| 5| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Tooth | + + + +| 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M + + + + + + M M + M M + M M + + M + + + +| 30 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + M + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 16 |
Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + M + M + +| 47 |
Lymphoma Malignant Mixed | | 2 |
Squamous Cell Carcinoma, Metastatic, | | |
Preputial Gland | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Sternal, Lymphoma Malignant | | |
Histiocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 3| 5| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 1| 2| 1| 1| 2| 2| 2| 1| 2| 2| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
UNTREATE | 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| L |
D 71UM | 4| 5| 2| 3| 4| 5| 1| 2| 3| 5| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Sternal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + +| 8 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X| 1 |
Lumbar, Lymphoma Malignant Mixed | | 2 |
Mediastinal, Lymphoma Malignant Mixed| | 2 |
Pancreatic, Lymphoma Malignant Mixed | X | 2 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + M + + + M M + + + M + M + M + + + + + + +| 32 |
Lymphoma Malignant Lymphocytic | X| 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +| 46 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X| 1 |
Lymphoma Malignant Mixed | X X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X| 1 |
Lymphoma Malignant Mixed | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Thymus | M M + I + + + + + + + + + + + + + + + + + M + I +| 37 |
Lymphoma Malignant Mixed | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibroma | | 2 |
Subcutaneous Tissue, Fibrosarcoma | X X | 3 |
Subcutaneous Tissue, Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 3| 5| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 1| 2| 1| 1| 2| 2| 2| 1| 2| 2| 1| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
UNTREATE | 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| L |
D 71UM | 4| 5| 2| 3| 4| 5| 1| 2| 3| 5| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Intercostal, Lymphoma Malignant Mixed| | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X | 7 |
Alveolar/Bronchiolar Carcinoma | X | 3 |
Hepatocellular Carcinoma, Metastatic | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 2 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Nose | + M + + + + + + + + + + + + + + + M + + + M + M +| 43 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Fibrosarcoma | X | 1 |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X| 1 |
Lymphoma Malignant Mixed | X X | 7 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 6| 5| 4| 7| 7| 7| 5| 7| 6| 6| 1|
DAY ON TEST | 2| 2| 7| 7| 0| 3| 3| 8| 1| 3| 3| 5| 3| 3| 1| 7| 5| 3| 3| 3| 8| 3| 4| 1| 5|
| 9| 9| 3| 3| 5| 0| 0| 9| 3| 0| 0| 4| 3| 0| 2| 2| 1| 0| 0| 0| 3| 0| 8| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
71LM | 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + + + + + + + + + + + + M + +|
Lymphoma Malignant Mixed | X |
Sarcoma, Metastatic, Stomach, | |
Forestomach | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + M + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
Mast Cell Tumor Malignant | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + M A + + + + + M + + + + + + + + + A|
Lymphoma Malignant Mixed | |
Mast Cell Tumor Malignant | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + M +|
Adenocarcinoma | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Mast Cell Tumor Malignant | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatoblastoma | X X |
Hepatocellular Carcinoma | X X X X X X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
Sarcoma, Metastatic, Stomach, | |
Forestomach | |
Squamous Cell Carcinoma, Metastatic, | |
Tissue NOS | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X X X X |
__________________________________________________________________________|
Mesentery | + + + + |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 6| 5| 4| 7| 7| 7| 5| 7| 6| 6| 1|
DAY ON TEST | 2| 2| 7| 7| 0| 3| 3| 8| 1| 3| 3| 5| 3| 3| 1| 7| 5| 3| 3| 3| 8| 3| 4| 1| 5|
| 9| 9| 3| 3| 5| 0| 0| 9| 3| 0| 0| 4| 3| 0| 2| 2| 1| 0| 0| 0| 3| 0| 8| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
71LM | 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Sarcoma, Metastatic, Stomach, | |
Forestomach | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
Sarcoma, Metastatic, Stomach, | |
Forestomach | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submandibular Gland, Lymphoma | |
Malignant Mixed | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | |
Mast Cell Tumor Malignant | X |
Squamous Cell Carcinoma | X X X X X X X X |
Squamous Cell Papilloma | X X X X X X X X X X |
Squamous Cell Papilloma, Multiple | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Mast Cell Tumor Malignant | X |
Sarcoma | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Sarcoma, Metastatic, Stomach, | |
Forestomach | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + M + M + + M + + + + M + + + + M M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + M + + + M + M + + +|
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 6| 5| 4| 7| 7| 7| 5| 7| 6| 6| 1|
DAY ON TEST | 2| 2| 7| 7| 0| 3| 3| 8| 1| 3| 3| 5| 3| 3| 1| 7| 5| 3| 3| 3| 8| 3| 4| 1| 5|
| 9| 9| 3| 3| 5| 0| 0| 9| 3| 0| 0| 4| 3| 0| 2| 2| 1| 0| 0| 0| 3| 0| 8| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
71LM | 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
Sarcoma, Metastatic, Stomach, | |
Forestomach | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | M + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + M + + + + + M + + + + + + + + M +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Sarcoma, Metastatic, Stomach, | |
Forestomach | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + M|
Mast Cell Tumor Malignant | |
Sternal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + + + + + |
Inguinal, Lymphoma Malignant Mixed | X |
Lumbar, Histiocytic Sarcoma | |
Lumbar, Lymphoma Malignant Mixed | X |
Mediastinal, Histiocytic Sarcoma | |
Mediastinal, Lymphoma Malignant Mixed| X |
Mediastinal, Squamous Cell Carcinoma,| |
Metastatic, Stomach, Forestomach| X X |
Pancreatic, Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 6| 5| 4| 7| 7| 7| 5| 7| 6| 6| 1|
DAY ON TEST | 2| 2| 7| 7| 0| 3| 3| 8| 1| 3| 3| 5| 3| 3| 1| 7| 5| 3| 3| 3| 8| 3| 4| 1| 5|
| 9| 9| 3| 3| 5| 0| 0| 9| 3| 0| 0| 4| 3| 0| 2| 2| 1| 0| 0| 0| 3| 0| 8| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
71LM | 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Lymphoma Malignant | |
Histiocytic | |
Renal, Histiocytic Sarcoma | |
Renal, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + + M + + M + + + M M M + + + I + + + + M M +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
Mast Cell Tumor Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + M|
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Mast Cell Tumor Malignant | X |
Sarcoma, Metastatic, Stomach, | |
Forestomach | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
Mast Cell Tumor Malignant | X |
Mesothelioma Malignant | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Thymus | + + M + M + + M M + + + + + M M + + + M + + + + +|
Lymphoma Malignant Mixed | X |
Mast Cell Tumor Malignant | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + M + + + + + + + M|
Lymphoma Malignant Mixed | X |
Mast Cell Tumor Malignant | X |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 6| 5| 4| 7| 7| 7| 5| 7| 6| 6| 1|
DAY ON TEST | 2| 2| 7| 7| 0| 3| 3| 8| 1| 3| 3| 5| 3| 3| 1| 7| 5| 3| 3| 3| 8| 3| 4| 1| 5|
| 9| 9| 3| 3| 5| 0| 0| 9| 3| 0| 0| 4| 3| 0| 2| 2| 1| 0| 0| 0| 3| 0| 8| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
71LM | 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibroma, | |
Multiple | |
Subcutaneous Tissue, Fibrosarcoma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Skeletal Muscle | + |
Diaphragm, Sarcoma, Metastatic, | |
Stomach, Forestomach | |
Diaphragm, Squamous Cell Carcinoma, | |
Metastatic, Stomach, Forestomach| X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X X X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
Sarcoma, Metastatic, Stomach, | |
Forestomach | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X X X |
__________________________________________________________________________|
Nose | + + M + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 6| 5| 4| 7| 7| 7| 5| 7| 6| 6| 1|
DAY ON TEST | 2| 2| 7| 7| 0| 3| 3| 8| 1| 3| 3| 5| 3| 3| 1| 7| 5| 3| 3| 3| 8| 3| 4| 1| 5|
| 9| 9| 3| 3| 5| 0| 0| 9| 3| 0| 0| 4| 3| 0| 2| 2| 1| 0| 0| 0| 3| 0| 8| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|
71LM | 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X |
Mast Cell Tumor Malignant | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
Mast Cell Tumor Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 0| 5| 3| 3| 1| 8| 7| 3| 3| 1| 1| 3| 3| 3| 3|
| 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 6| 0| 0| 0| 7| 2| 8| 0| 0| 5| 4| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + + + + M + + + + + + + +|
Lymphoma Malignant Mixed | |
Sarcoma, Metastatic, Stomach, | |
Forestomach | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
Mast Cell Tumor Malignant | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Mast Cell Tumor Malignant | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Mast Cell Tumor Malignant | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatoblastoma | X |
Hepatocellular Carcinoma | X X X X X X|
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X|
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
Sarcoma, Metastatic, Stomach, | |
Forestomach | X |
Squamous Cell Carcinoma, Metastatic, | |
Tissue NOS | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Mesentery | + + + |
Lymphoma Malignant Histiocytic | X |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 0| 5| 3| 3| 1| 8| 7| 3| 3| 1| 1| 3| 3| 3| 3|
| 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 6| 0| 0| 0| 7| 2| 8| 0| 0| 5| 4| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Sarcoma, Metastatic, Stomach, | |
Forestomach | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + M + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
Sarcoma, Metastatic, Stomach, | |
Forestomach | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submandibular Gland, Lymphoma | |
Malignant Mixed | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + + + + + +|
Leiomyosarcoma | X |
Mast Cell Tumor Malignant | |
Squamous Cell Carcinoma | X X X X |
Squamous Cell Papilloma | X |
Squamous Cell Papilloma, Multiple | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + I + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Mast Cell Tumor Malignant | |
Sarcoma | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Sarcoma, Metastatic, Stomach, | |
Forestomach | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M + + + + + + + + + + + M + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + +|
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 0| 5| 3| 3| 1| 8| 7| 3| 3| 1| 1| 3| 3| 3| 3|
| 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 6| 0| 0| 0| 7| 2| 8| 0| 0| 5| 4| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
Sarcoma, Metastatic, Stomach, | |
Forestomach | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + I + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Sarcoma, Metastatic, Stomach, | |
Forestomach | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mast Cell Tumor Malignant | X |
Sternal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + + |
Inguinal, Lymphoma Malignant Mixed | |
Lumbar, Histiocytic Sarcoma | |
Lumbar, Lymphoma Malignant Mixed | |
Mediastinal, Histiocytic Sarcoma | |
Mediastinal, Lymphoma Malignant Mixed| |
Mediastinal, Squamous Cell Carcinoma,| |
Metastatic, Stomach, Forestomach| |
Pancreatic, Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 0| 5| 3| 3| 1| 8| 7| 3| 3| 1| 1| 3| 3| 3| 3|
| 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 6| 0| 0| 0| 7| 2| 8| 0| 0| 5| 4| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Lymphoma Malignant | |
Histiocytic | X |
Renal, Histiocytic Sarcoma | |
Renal, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M M M + + + M + M + + + + + + + + M + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | |
Mast Cell Tumor Malignant | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Mast Cell Tumor Malignant | |
Sarcoma, Metastatic, Stomach, | |
Forestomach | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Mast Cell Tumor Malignant | X |
Mesothelioma Malignant | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Thymus | + + + M M + + + + M + + + + M + + M M + + + M|
Lymphoma Malignant Mixed | |
Mast Cell Tumor Malignant | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M + M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + M + + + +|
Lymphoma Malignant Mixed | |
Mast Cell Tumor Malignant | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 0| 5| 3| 3| 1| 8| 7| 3| 3| 1| 1| 3| 3| 3| 3|
| 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 6| 0| 0| 0| 7| 2| 8| 0| 0| 5| 4| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Fibroma, | |
Multiple | X |
Subcutaneous Tissue, Fibrosarcoma | X X X X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Diaphragm, Sarcoma, Metastatic, | |
Stomach, Forestomach | X |
Diaphragm, Squamous Cell Carcinoma, | |
Metastatic, Stomach, Forestomach| X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X X X X |
Alveolar/Bronchiolar Carcinoma | X X X|
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | |
Sarcoma, Metastatic, Stomach, | |
Forestomach | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | X |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 0| 5| 3| 3| 1| 8| 7| 3| 3| 1| 1| 3| 3| 3| 3|
| 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 6| 0| 0| 0| 7| 2| 8| 0| 0| 5| 4| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | |
Mast Cell Tumor Malignant | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Urinary Bladder | + + + + I + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | |
Mast Cell Tumor Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 4| | |
| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE MALE | 0| | T |
ANIMAL ID | 2| | A |
1.0% | 4| | L |
71LM | 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 47 |
__________________________________________________________________________|____________|
Gallbladder | + | 47 |
Lymphoma Malignant Mixed | | 1 |
Sarcoma, Metastatic, Stomach, | | |
Forestomach | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 49 |
Mast Cell Tumor Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 51 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Mast Cell Tumor Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 50 |
Mast Cell Tumor Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 47 |
Lymphoma Malignant Mixed | | 1 |
Mast Cell Tumor Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 49 |
Adenocarcinoma | | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Mast Cell Tumor Malignant | | 1 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Hemangiosarcoma | | 2 |
Hepatoblastoma | | 3 |
Hepatocellular Carcinoma | | 15 |
Hepatocellular Carcinoma, Multiple | | 3 |
Hepatocellular Adenoma | X | 9 |
Hepatocellular Adenoma, Multiple | | 29 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Sarcoma, Metastatic, Stomach, | | |
Forestomach | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 4| | |
| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE MALE | 0| | T |
ANIMAL ID | 2| | A |
1.0% | 4| | L |
71LM | 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Tissue NOS | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 4 |
__________________________________________________________________________|____________|
Mesentery | | 7 |
Lymphoma Malignant Histiocytic | | 1 |
Sarcoma, Metastatic, Stomach, | | |
Forestomach | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 2 |
__________________________________________________________________________|____________|
Pancreas | + | 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Sarcoma, Metastatic, Stomach, | | |
Forestomach | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
Submandibular Gland, Lymphoma | | |
Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 50 |
Leiomyosarcoma | | 1 |
Mast Cell Tumor Malignant | | 1 |
Squamous Cell Carcinoma | | 12 |
Squamous Cell Papilloma | | 11 |
Squamous Cell Papilloma, Multiple | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 50 |
Histiocytic Sarcoma | X | 1 |
Mast Cell Tumor Malignant | | 1 |
Sarcoma | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 51 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 4| | |
| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE MALE | 0| | T |
ANIMAL ID | 2| | A |
1.0% | 4| | L |
71LM | 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Adenoma | | 1 |
Sarcoma, Metastatic, Stomach, | | |
Forestomach | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + | 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M | 37 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 45 |
Pars Distalis, Adenoma | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Epididymis | + | 51 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Sarcoma, Metastatic, Stomach, | | |
Forestomach | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 16 |
__________________________________________________________________________|____________|
Prostate | + | 46 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Testes | + | 50 |
Lymphoma Malignant Mixed | | 1 |
Sarcoma, Metastatic, Stomach, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 4| | |
| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE MALE | 0| | T |
ANIMAL ID | 2| | A |
1.0% | 4| | L |
71LM | 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Forestomach | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 50 |
Mast Cell Tumor Malignant | | 1 |
Sternal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + | 8 |
Inguinal, Lymphoma Malignant Mixed | | 1 |
Lumbar, Histiocytic Sarcoma | X | 1 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Mediastinal, Histiocytic Sarcoma | X | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
Mediastinal, Squamous Cell Carcinoma,| | |
Metastatic, Stomach, Forestomach| | 2 |
Pancreatic, Histiocytic Sarcoma | X | 1 |
Pancreatic, Lymphoma Malignant | | |
Histiocytic | | 1 |
Renal, Histiocytic Sarcoma | X | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 34 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Mixed | | 1 |
Mast Cell Tumor Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 47 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Mast Cell Tumor Malignant | | 1 |
Sarcoma, Metastatic, Stomach, | | |
Forestomach | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 2 |
__________________________________________________________________________|____________|
Spleen | + | 51 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 4| | |
| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE MALE | 0| | T |
ANIMAL ID | 2| | A |
1.0% | 4| | L |
71LM | 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
Mast Cell Tumor Malignant | | 2 |
Mesothelioma Malignant | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Thymus | + | 35 |
Lymphoma Malignant Mixed | | 1 |
Mast Cell Tumor Malignant | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M | 1 |
__________________________________________________________________________|____________|
Skin | + | 48 |
Lymphoma Malignant Mixed | | 1 |
Mast Cell Tumor Malignant | | 1 |
Squamous Cell Carcinoma | | 1 |
Subcutaneous Tissue, Fibroma | | 2 |
Subcutaneous Tissue, Fibroma, | | |
Multiple | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 8 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
Diaphragm, Sarcoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
Diaphragm, Squamous Cell Carcinoma, | | |
Metastatic, Stomach, Forestomach| | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 4| | |
| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE MALE | 0| | T |
ANIMAL ID | 2| | A |
1.0% | 4| | L |
71LM | 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Adenoma | X | 20 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 6 |
Alveolar/Bronchiolar Carcinoma | | 3 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Mixed | | 1 |
Sarcoma, Metastatic, Stomach, | | |
Forestomach | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 3 |
__________________________________________________________________________|____________|
Nose | + | 49 |
__________________________________________________________________________|____________|
Trachea | + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Mast Cell Tumor Malignant | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Mixed | | 1 |
Mast Cell Tumor Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + | 51 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 4| | |
| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE MALE | 0| | T |
ANIMAL ID | 2| | A |
1.0% | 4| | L |
71LM | 5| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 5| 4| 1| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 2| 4| 9| 8| 3| 2| 2| 2| 2| 1| 2| 2| 8| 4| 2| 2| 2| 0| 2| 2| 2| 9|
| 9| 9| 9| 9| 8| 3| 4| 6| 9| 9| 9| 9| 3| 9| 9| 9| 5| 9| 9| 1| 6| 9| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
2.0% | 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|
71HM | 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + M + + M + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Lymphoma Malignant Lymphocytic | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + M|
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Stomach, | |
Forestomach | |
Hemangiosarcoma | X |
Hepatoblastoma | X |
Hepatocellular Carcinoma | X X X X X X X X |
Hepatocellular Carcinoma, Multiple | X X X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X|
Hepatocholangiocarcinoma, Multiple | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Mesentery | + +|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 5| 4| 1| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 2| 4| 9| 8| 3| 2| 2| 2| 2| 1| 2| 2| 8| 4| 2| 2| 2| 0| 2| 2| 2| 9|
| 9| 9| 9| 9| 8| 3| 4| 6| 9| 9| 9| 9| 3| 9| 9| 9| 5| 9| 9| 1| 6| 9| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
2.0% | 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|
71HM | 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + M + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X X X X X|
Squamous Cell Papilloma | X X X X X X X |
Squamous Cell Papilloma, Multiple | X X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X|
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + M + M + + M + M + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Stomach, | |
Forestomach | |
Lymphoma Malignant Lymphocytic | X |
Squamous Cell Carcinoma, Metastatic, | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 5| 4| 1| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 2| 4| 9| 8| 3| 2| 2| 2| 2| 1| 2| 2| 8| 4| 2| 2| 2| 0| 2| 2| 2| 9|
| 9| 9| 9| 9| 8| 3| 4| 6| 9| 9| 9| 9| 3| 9| 9| 9| 5| 9| 9| 1| 6| 9| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
2.0% | 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|
71HM | 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Stomach, Forestomach | |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + |
__________________________________________________________________________|
Prostate | + + + + + M + + + + + + + + + + + + + + + + + M +|
Lymphoma Malignant Lymphocytic | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + M +|
Fibrosarcoma, Metastatic, Stomach, | |
Forestomach | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node | + + + + +|
Lumbar, Lymphoma Malignant Mixed | |
Mediastinal, Squamous Cell Carcinoma,| |
Metastatic, Stomach, Forestomach| |
Pancreatic, Lymphoma Malignant Mixed | X X |
Pancreatic, Squamous Cell Carcinoma, | |
Metastatic, Stomach, Forestomach| |
Renal, Lymphoma Malignant Lymphocytic| X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M M + M M M + M + + M M + M + + M + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + M + M + M M + + + + + + + + M + I + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 5| 4| 1| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 2| 4| 9| 8| 3| 2| 2| 2| 2| 1| 2| 2| 8| 4| 2| 2| 2| 0| 2| 2| 2| 9|
| 9| 9| 9| 9| 8| 3| 4| 6| 9| 9| 9| 9| 3| 9| 9| 9| 5| 9| 9| 1| 6| 9| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
2.0% | 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|
71HM | 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + M|
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Squamous Cell Carcinoma, | |
Metastatic, Stomach, Forestomach| |
Diaphragm, Squamous Cell Carcinoma, | |
Metastatic, Stomach, Forestomach| |
Intercostal, Lymphoma Malignant | |
Lymphocytic | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X X X X|
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Mediastinum, Hemangiosarcoma, | |
Metastatic, Spleen | |
__________________________________________________________________________|
Nose | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 5| 4| 1| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 2| 4| 9| 8| 3| 2| 2| 2| 2| 1| 2| 2| 8| 4| 2| 2| 2| 0| 2| 2| 2| 9|
| 9| 9| 9| 9| 8| 3| 4| 6| 9| 9| 9| 9| 3| 9| 9| 9| 5| 9| 9| 1| 6| 9| 9| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
2.0% | 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|
71HM | 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 6| 6| 2| 7| 7| 6| 5| 6| 2| 1| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 1| 4| 2| 2| 3| 1| 8| 4| 0| 2| 2| 2| 1| |
| 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 5| 8| 8| 9| 4| 3| 2| 9| 9| 9| 9| 9| 2| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| L |
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 4| 5| 1| 2| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + M + + + + + + + + + + + M + + + M + + A + + + M| 42 |
Lymphoma Malignant Lymphocytic | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + M + + + + + + + + +| 48 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + M + + + +| 46 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Lymphoma Malignant Mixed | X | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + + M + + + +| 47 |
Adenocarcinoma | X X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosarcoma, Metastatic, Stomach, | | |
Forestomach | X | 1 |
Hemangiosarcoma | | 1 |
Hepatoblastoma | X X X X | 5 |
Hepatocellular Carcinoma | X X X X| 12 |
Hepatocellular Carcinoma, Multiple | X X X X X X | 9 |
Hepatocellular Adenoma | X X X X X X| 8 |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X | 31 |
Hepatocholangiocarcinoma, Multiple | | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 6| 6| 2| 7| 7| 6| 5| 6| 2| 1| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 1| 4| 2| 2| 3| 1| 8| 4| 0| 2| 2| 2| 1| |
| 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 5| 8| 8| 9| 4| 3| 2| 9| 9| 9| 9| 9| 2| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| L |
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 4| 5| 1| 2| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X X X X | 4 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 9 |
Lymphoma Malignant Lymphocytic | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X X X X X | 5 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
Lymphoma Malignant Mixed | X | 2 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Carcinoma | X X X X X X X X | 13 |
Squamous Cell Papilloma | X X X X| 11 |
Squamous Cell Papilloma, Multiple | X X | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X X X | 4 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | + + + | 7 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + M M + + + + M + + + M + + + + + + + M +| 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M M + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
C-Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 6| 6| 2| 7| 7| 6| 5| 6| 2| 1| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 1| 4| 2| 2| 3| 1| 8| 4| 0| 2| 2| 2| 1| |
| 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 5| 8| 8| 9| 4| 3| 2| 9| 9| 9| 9| 9| 2| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| L |
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 4| 5| 1| 2| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosarcoma, Metastatic, Stomach, | | |
Forestomach | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 1 |
__________________________________________________________________________|____________|
Penis | + | 2 |
__________________________________________________________________________|____________|
Preputial Gland | M + + + + + + | 12 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Lymphocytic | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + M + + + + + + + +| 45 |
Fibrosarcoma, Metastatic, Stomach, | | |
Forestomach | X | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 11 |
Lumbar, Lymphoma Malignant Mixed | X | 1 |
Mediastinal, Squamous Cell Carcinoma,| | |
Metastatic, Stomach, Forestomach| X | 1 |
Pancreatic, Lymphoma Malignant Mixed | X X | 4 |
Pancreatic, Squamous Cell Carcinoma, | | |
Metastatic, Stomach, Forestomach| X | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 6| 6| 2| 7| 7| 6| 5| 6| 2| 1| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 1| 4| 2| 2| 3| 1| 8| 4| 0| 2| 2| 2| 1| |
| 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 5| 8| 8| 9| 4| 3| 2| 9| 9| 9| 9| 9| 2| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| L |
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 4| 5| 1| 2| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M I M M M M M + M M + + + + + + M + M M M + M + +| 26 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + M + M + +| 47 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Thymus | + M M + + M M + M M + + + + + M M + M + + + + M +| 33 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Subcutaneous Tissue, Fibroma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 3 |
Abdominal, Squamous Cell Carcinoma, | | |
Metastatic, Stomach, Forestomach| X X | 2 |
Diaphragm, Squamous Cell Carcinoma, | | |
Metastatic, Stomach, Forestomach| X | 1 |
Intercostal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X X X | 15 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X X X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 05061-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/03/97
Route: DOSED FEED Time: 13:30:59
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 6| 6| 2| 7| 7| 6| 5| 6| 2| 1| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 1| 4| 2| 2| 3| 1| 8| 4| 0| 2| 2| 2| 1| |
| 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 5| 8| 8| 9| 4| 3| 2| 9| 9| 9| 9| 9| 2| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| L |
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 4| 5| 1| 2| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Carcinoma | | 1 |
Hepatocellular Carcinoma, Metastatic | X X | 2 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Mediastinum, Hemangiosarcoma, | | |
Metastatic, Spleen | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 63
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