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TR 383 Mouse Pathology Tables

NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97
Route: DOSED FEED                                                                                                 Time: 13:30:59

                                                          CORE ANIMALS




       Facility:  TSI Mason Research

       Chemical CAS #:  81-49-2

       Lock Date:  03/25/92

       Cage Range:  All

       Reasons For Removal:    25008 Accident                          25004 Dead
                               25003 Moribund                          25006 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All

































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 9| 3| 3| 1| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 2| 5| 3| 3| 4| 2| 3| 3| 0| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|             
    D 71UF                                 | 3| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 1| 4| 5| 1| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Malignant,        |                                                                          |             
          Metastatic, Uterus               |                               X                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Malignant,        |                                                                          |             
          Metastatic, Uterus               |                               X                                          |             
      Lymphoma Malignant Mixed             |    X                 X                                            X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hepatocellular Adenoma               |          X              X              X                                 |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                 X                    X                       X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +        +  +                              |             
      Basosquamous Tumor Malignant,        |                                                                          |             
          Metastatic, Uterus               |                               X                                          |             
      Lymphoma Malignant Mixed             |                                           X                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Malignant,        |                                                                          |             
          Metastatic, Uterus               |                               X                                          |             
      Lymphoma Malignant Mixed             |    X                 X                    X                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parotid Gland, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                      X                    X                              |             
      Sublingual Gland, Lymphoma Malignant |                                                                          |             
          Mixed                            |                                                                          |             
      Submandibular Gland, Lymphoma        |                                                                          |             
          Malignant Mixed                  |                                           X                       X      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Squamous Cell Papilloma              | X                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 9| 3| 3| 1| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 2| 5| 3| 3| 4| 2| 3| 3| 0| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|             
    D 71UF                                 | 3| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 1| 4| 5| 1| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  M  +  M  +  +  M  M  +  +  M  +  +  M  +  +  +  M  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Pars Distalis, Adenoma               |                                                                          |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Follicular Cell, Adenoma             |                                                                X  X  X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Basosquamous Tumor Malignant,        |                                                                          |             
          Metastatic, Uterus               |                               X                                          |             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Hemangioma                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                      X                              |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                                                         X|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Cervix, Basosquamous Tumor Malignant |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |    X                                      X                       X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +           +     +        +           +                              |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                X                                                         |             
      Mediastinal, Lymphoma Malignant Mixed|    X                                      X                              |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 9| 3| 3| 1| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 2| 5| 3| 3| 4| 2| 3| 3| 0| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|             
    D 71UF                                 | 3| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 1| 4| 5| 1| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                      X                                                   |             
      Renal, Basosquamous Tumor Malignant, |                                                                          |             
           Metastatic, Uterus              |                               X                                          |             
      Renal, Lymphoma Malignant Mixed      |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  M  +  M  +  +  M  +  +  +  M  +  M  +  +  M  +  M  +  +  M  M|             
      Lymphoma Malignant Mixed             |    X                 X                    X                       X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Malignant,        |                                                                          |             
          Metastatic, Uterus               |                               X                                          |             
      Lymphoma Malignant Mixed             |    X                                      X                       X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                X                                                         |             
      Lymphoma Malignant Mixed             |    X                 X                    X                       X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  I  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             |                      X                    X                              |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  M  M  M  +  +  +  +  +  +  M  M  +  +  M  +  +  M  M  +  +|             
      Fibroadenoma                         |       X                                                                  |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Squamous Cell Papilloma              |                                                    X                     |             
      Subcutaneous Tissue, Fibrosarcoma    |                               X                                          |             
      Subcutaneous Tissue, Hemangioma      |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Rib, Osteosarcoma                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                          +           +                              |             
      Diaphragm, Basosquamous Tumor        |                                                                          |             
          Malignant, Metastatic, Uterus    |                               X                                          |             
      Intercostal, Lymphoma Malignant Mixed|    X                                      X                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Lymphoma Malignant Mixed   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X                                                              X   |             
      Basosquamous Tumor Malignant,        |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 5| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 3| 3| 3| 9| 3| 3| 1| 7| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 4| 2| 5| 3| 3| 4| 2| 3| 3| 0| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATE                               | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3|             
    D 71UF                                 | 3| 4| 5| 2| 3| 4| 5| 1| 2| 4| 5| 1| 2| 3| 4| 1| 4| 5| 1| 2| 3| 4| 5| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Metastatic, Uterus               |                               X                                          |             
      Lymphoma Malignant Mixed             |                                           X                       X      |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Mediastinum, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                X                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                         +|             
      Adenoma                              |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                      X                    X                       X      |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                X                                                         |             
      Lymphoma Malignant Mixed             |    X                 X                    X                       X      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   5                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 3| 3| 3| 0| 0|            |
                                           | 3| 3| 3| 3| 3| 3| 4| 6| 3| 3| 4| 4| 3| 4| 8| 3| 8| 3| 3| 3| 4| 4| 4| 6| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    UNTREATE                               | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8|     L      |
    D 71UF                                 | 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basosquamous Tumor Malignant,        |                                                                          |            |
          Metastatic, Uterus               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Basosquamous Tumor Malignant,        |                                                                          |            |
          Metastatic, Uterus               |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                              X                           |          4 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Mixed             |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangioma                           |             X                                                            |          1 |
      Hepatocellular Adenoma               |                                     X                          X  X      |          6 |
      Lymphoma Malignant Histiocytic       |          X                                                               |          1 |
      Lymphoma Malignant Mixed             |                                              X                           |          5 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +           +           +   |   6        |
      Basosquamous Tumor Malignant,        |                                                                          |            |
          Metastatic, Uterus               |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basosquamous Tumor Malignant,        |                                                                          |            |
          Metastatic, Uterus               |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                              X                       X   |          5 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parotid Gland, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                              X                           |          3 |
      Sublingual Gland, Lymphoma Malignant |                                                                          |            |
          Mixed                            |                                              X                           |          1 |
      Submandibular Gland, Lymphoma        |                                                                          |            |
          Malignant Mixed                  |                                              X                           |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Mixed             |                                              X                           |          1 |
      Squamous Cell Papilloma              |                                                    X                     |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   6                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 3| 3| 3| 0| 0|            |
                                           | 3| 3| 3| 3| 3| 3| 4| 6| 3| 3| 4| 4| 3| 4| 8| 3| 8| 3| 3| 3| 4| 4| 4| 6| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    UNTREATE                               | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8|     L      |
    D 71UF                                 | 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                 +                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                              X                           |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma                            |                         X                                                |          1 |
      Lymphoma Malignant Mixed             |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  M  M  +  M  +  +  M  +  +  +  M  M  +  +  +  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Pars Distalis, Adenoma               |                                                 X                        |          1 |
      Pars Intermedia, Adenoma             |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                              X                           |          1 |
      Follicular Cell, Adenoma             |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basosquamous Tumor Malignant,        |                                                                          |            |
          Metastatic, Uterus               |                                                                          |          1 |
      Granulosa Cell Tumor Benign          |                                     X                                    |          1 |
      Hemangioma                           |                X                                                         |          1 |
      Lymphoma Malignant Histiocytic       |          X                                                               |          1 |
      Lymphoma Malignant Mixed             |                                              X                           |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leiomyoma                            |                X                                                         |          2 |
      Lymphoma Malignant Histiocytic       |          X                                                               |          1 |
      Lymphoma Malignant Mixed             |                                              X                           |          1 |
      Cervix, Basosquamous Tumor Malignant |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   7                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 3| 3| 3| 0| 0|            |
                                           | 3| 3| 3| 3| 3| 3| 4| 6| 3| 3| 4| 4| 3| 4| 8| 3| 8| 3| 3| 3| 4| 4| 4| 6| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    UNTREATE                               | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8|     L      |
    D 71UF                                 | 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                              X                           |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                              +                       +   |   7        |
      Axillary, Lymphoma Malignant Mixed   |                                              X                           |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                              X                           |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                              X                           |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          2 |
      Pancreatic, Lymphoma Malignant Mixed |                                              X                           |          2 |
      Renal, Basosquamous Tumor Malignant, |                                                                          |            |
           Metastatic, Uterus              |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  I  +  +  M  +  M  +  +  +  M  M  +  +  M  +  M  M  +  +  +  +|  32        |
      Lymphoma Malignant Mixed             |                                              X                           |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basosquamous Tumor Malignant,        |                                                                          |            |
          Metastatic, Uterus               |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                X                          X  X                           |          6 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangioma                           |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                X              X              X                           |          7 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  M  +  M  +  +  +  M  M  M|  40        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                              X                           |          3 |
      Osteosarcoma, Metastatic, Bone       |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  +  M  M  M  +  +  M  +  M  M  M  +  +  +  M  M  M  M  +  M  +|  25        |
      Fibroadenoma                         |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                              X                           |          2 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                         X|          2 |
      Subcutaneous Tissue, Hemangioma      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   8                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 3| 3| 3| 0| 0|            |
                                           | 3| 3| 3| 3| 3| 3| 4| 6| 3| 3| 4| 4| 3| 4| 8| 3| 8| 3| 3| 3| 4| 4| 4| 6| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    UNTREATE                               | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8|     L      |
    D 71UF                                 | 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Rib, Osteosarcoma                    |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                              +                           |   4        |
      Diaphragm, Basosquamous Tumor        |                                                                          |            |
          Malignant, Metastatic, Uterus    |                                                                          |          1 |
      Intercostal, Lymphoma Malignant Mixed|                                              X                           |          3 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Meninges, Lymphoma Malignant Mixed   |                               X                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                  X                          X            |          4 |
      Basosquamous Tumor Malignant,        |                                                                          |            |
          Metastatic, Uterus               |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                              X                           |          3 |
      Osteosarcoma, Metastatic, Bone       |                                           X                              |          1 |
      Mediastinum, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Mixed             |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                               X              X                           |          5 |
      Osteosarcoma, Metastatic, Bone       |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                              X                           |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |          X                                                               |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   9                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 5| 2| 3| 3| 3| 3| 3| 3| 0| 0|            |
                                           | 3| 3| 3| 3| 3| 3| 4| 6| 3| 3| 4| 4| 3| 4| 8| 3| 8| 3| 3| 3| 4| 4| 4| 6| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     A      |
    UNTREATE                               | 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8|     L      |
    D 71UF                                 | 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                X              X           X  X                       X   |          9 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  10                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3|             
                                           | 0| 0| 0| 7| 2| 0| 0| 0| 0| 2| 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 6| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 1| 2| 3| 4| 1| 2| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                              X                    X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hepatocellular Carcinoma             |                                        X        X  X     X  X            |             
      Hepatocellular Carcinoma, Multiple   |       X        X  X           X                       X              X   |             
      Hepatocellular Adenoma               |                X                                                     X   |             
      Hepatocellular Adenoma, Multiple     | X  X     X        X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X|             
      Lymphoma Malignant Mixed             |          X                                   X                    X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                             X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +  +                             +            |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                             X            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Lymphoma Malignant Mixed             |                                              X                           |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Squamous Cell Carcinoma              |       X                 X                 X  X  X  X        X           X|             
      Squamous Cell Papilloma              |                X                 X     X        X                        |             
      Squamous Cell Papilloma, Multiple    |                                                                         X|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  11                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3|             
                                           | 0| 0| 0| 7| 2| 0| 0| 0| 0| 2| 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 6| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 1| 2| 3| 4| 1| 2| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |          X                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  +  +  M  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  I  +  +  M  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  I  +|             
      Pars Distalis, Adenoma               | X                                                        X  X            |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
      Pars Distalis, Lymphoma Malignant    |                                                                          |             
          Mixed                            |          X                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Luteoma                              |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                             X            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |                                                                          |             
      Sarcoma Stromal                      |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +  +     +           +                 +  +   |             
      Iliac, Lymphoma Malignant Mixed      |                                                                   X      |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                      X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  12                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3|             
                                           | 0| 0| 0| 7| 2| 0| 0| 0| 0| 2| 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 6| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 1| 2| 3| 4| 1| 2| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Stomach, Forestomach|                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                               X                 X                 X      |             
      Renal, Lymphoma Malignant Mixed      |                                                                   X  X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                X                             X                           |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                             X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |          X                                   X                           |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  M  M  +  +  +  +  +  +  M  +|             
      Lymphoma Malignant Mixed             |                                                                   X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  M  M  M  M  +  M  +  M  M  M  M  M  +  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                             +            |             
      Abdominal, Fibrosarcoma, Metastatic, |                                                                          |             
           Skin                            |                                                                          |             
      Diaphragm, Squamous Cell Carcinoma,  |                                                                          |             
           Metastatic, Stomach, Forestomach|                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         | X              X  X     X        X  X  X        X  X  X                  |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                   X      |             
      Lymphoma Malignant Mixed             |          X                                                        X  X   |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  13                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3|             
                                           | 0| 0| 0| 7| 2| 0| 0| 0| 0| 2| 0| 0| 0| 3| 0| 0| 0| 0| 0| 0| 6| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|             
    71LF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 1| 2| 3| 4| 1| 2| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                             X            |             
      Pleura, Lymphoma Malignant           |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +           +                                                            |             
      Adenoma                              | X                                                                        |             
      Carcinoma                            |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                   X  X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |          X     X              X              X  X                 X  X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  14                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 5| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 7| 7| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 5|            |
                                           | 7| 0| 0| 7| 0| 0| 6| 3| 2| 3| 0| 9| 1| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|     A      |
    1.0%                                   | 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0|     L      |
    71LF                                   | 4| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|  45        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Mixed             |                                                                X         |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                X         |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Skin       |          X                                                               |          1 |
      Hepatocellular Carcinoma             |          X           X                       X  X                    X   |         10 |
      Hepatocellular Carcinoma, Multiple   |       X     X     X        X  X                             X  X         |         13 |
      Hepatocellular Adenoma               |                   X  X                                                  X|          5 |
      Hepatocellular Adenoma, Multiple     | X  X  X  X  X  X           X  X     X  X  X  X  X     X  X  X  X  X  X   |         40 |
      Lymphoma Malignant Mixed             |    X                                X                          X         |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X              X                                 |          2 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                  X                 X                     |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                       +  +        +     +                 +   |   9        |
      Fibrosarcoma, Metastatic, Skin       |          X                                                               |          1 |
      Lymphoma Malignant Mixed             |                                     X                                    |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                  X                                       |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Skin       |          X                                                               |          1 |
      Lymphoma Malignant Mixed             |                                     X                 X        X         |          4 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                X         |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
      Squamous Cell Carcinoma              | X                 X              X                 X                     |         12 |
      Squamous Cell Papilloma              |       X  X  X                 X     X     X                 X        X   |         12 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  15                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 5| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 7| 7| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 5|            |
                                           | 7| 0| 0| 7| 0| 0| 6| 3| 2| 3| 0| 9| 1| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|     A      |
    1.0%                                   | 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0|     L      |
    71LF                                   | 4| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Papilloma, Multiple    |                   X        X                             X               |          4 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                  X                 X                     |          3 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                X                                                         |          1 |
      Lymphoma Malignant Mixed             |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Pars Distalis, Adenoma               |       X                             X     X                       X  X   |          8 |
      Pars Distalis, Adenoma, Multiple     |             X                                                            |          1 |
      Pars Distalis, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                +         |   1        |
      Lymphoma Malignant Mixed             |                                                                X         |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                         M                                                |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Luteoma                              |                                     X                                    |          1 |
      Lymphoma Malignant Mixed             |                                                                X         |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Polyp Stromal                        | X                                X                                       |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  16                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 5| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 7| 7| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 5|            |
                                           | 7| 0| 0| 7| 0| 0| 6| 3| 2| 3| 0| 9| 1| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|     A      |
    1.0%                                   | 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0|     L      |
    71LF                                   | 4| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Sarcoma Stromal                      |                X                    X                                    |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +                             +  +                 +        +         |  12        |
      Iliac, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                                       X                  |          1 |
      Mediastinal, Lymphoma Malignant Mixed|    X                                X                 X                  |          4 |
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |            |
           Metastatic, Stomach, Forestomach|                                  X                                       |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                     X                 X        X         |          6 |
      Renal, Lymphoma Malignant Mixed      |                                     X                 X                  |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  45        |
      Lymphoma Malignant Mixed             |    X                                                  X        X         |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Lymphoma Malignant Mixed             |    X                                      X           X     X  X         |          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                        X                                 |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                     X     X           X     X  X         |          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X              X                                 |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  M  +  +  +|  38        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  M  M  M  +  M  M  M  +  +  M  +  +  +  M  M  M  M  +  +|  25        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Fibrosarcoma    |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   2        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  17                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 7| 7| 7| 5| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 8| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 7| 7| 4| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 5|            |
                                           | 7| 0| 0| 7| 0| 0| 6| 3| 2| 3| 0| 9| 1| 2| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|     A      |
    1.0%                                   | 4| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0|     L      |
    71LF                                   | 4| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Abdominal, Fibrosarcoma, Metastatic, |                                                                          |            |
           Skin                            |          X                                                               |          1 |
      Diaphragm, Squamous Cell Carcinoma,  |                                                                          |            |
           Metastatic, Stomach, Forestomach|                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         | X        X     X           X                             X               |         15 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                               X                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                X         |          4 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
      Pleura, Lymphoma Malignant           |                                                                          |            |
          Undifferentiated Cell Type       |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                       +                  |   3        |
      Adenoma                              |                                                       X                  |          2 |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                     X                          X         |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                X         |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |    X                                X     X           X     X  X         |         13 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                         X              X                                 |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  18                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 1| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3|             
                                           | 9| 9| 9| 8| 3| 9| 9| 9| 9| 9| 3| 3| 1| 3| 9| 9| 9| 9| 0| 0| 0| 9| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                X                                      X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                    X                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatoblastoma                       |       X           X                                                      |             
      Hepatocellular Carcinoma             |       X           X     X  X           X                                 |             
      Hepatocellular Carcinoma, Multiple   |          X  X  X     X        X                 X  X     X               |             
      Hepatocellular Adenoma               |                                     X  X  X                              |             
      Hepatocellular Adenoma, Multiple     | X  X  X  X  X  X  X  X  X  X  X  X           X  X  X  X  X  X  X  X  X  X|             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |          X                 X        X                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +           +     +  +                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |          X                 X                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                X                                               X         |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |          X                          X                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parotid Gland, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
      Sublingual Gland, Lymphoma Malignant |                                                                          |             
          Mixed                            |                                                                          |             
      Submandibular Gland, Lymphoma        |                                                                          |             
          Malignant Mixed                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma                              |                                                                          |             
      Squamous Cell Carcinoma              | X        X  X  X     X     X        X                                    |             
      Squamous Cell Papilloma              |                      X  X                    X  X           X  X         |             
      Squamous Cell Papilloma, Multiple    | X  X  X  X        X                       X        X     X               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  19                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 1| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3|             
                                           | 9| 9| 9| 8| 3| 9| 9| 9| 9| 9| 3| 3| 1| 3| 9| 9| 9| 9| 0| 0| 0| 9| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Sarcoma                              |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |          X                 X                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Squamous Cell Carcinoma, Metastatic  |                                     X                                    |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  M  +  +  M  M  +  +  +  M  M  +  M  +  M  +  +  M  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +|             
      Pars Distalis, Adenoma               |                      X                                                   |             
      Pars Nervosa, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Follicular Cell, Adenoma             |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                               +                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                            X        X                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                               +                                          |             
      Squamous Cell Carcinoma              |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +        +           +                    +     +            |             
      Axillary, Lymphoma Malignant Mixed   |                                                                          |             
      Bronchial, Lymphoma Malignant Mixed  |                                                                          |             
      Bronchial, Sarcoma, Metastatic,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  20                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 1| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3|             
                                           | 9| 9| 9| 8| 3| 9| 9| 9| 9| 9| 3| 3| 1| 3| 9| 9| 9| 9| 0| 0| 0| 9| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Stomach, Forestomach             |                                                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |             X                                                            |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Stomach, Forestomach|                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |             X                                         X                  |             
      Renal, Lymphoma Malignant Mixed      |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  I  +  +  +  M  M  +  M  +  M  M  +  M  +  +  M|             
      Lymphoma Malignant Mixed             |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |    X        X  X                                               X         |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                     X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             | X           X                                                            |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  M  M  M  +  M  M  M  M  +  +  +  +  M  M  M  M  +  M  M  +  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Mixed                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
      Diaphragm, Squamous Cell Carcinoma,  |                                                                          |             
           Metastatic, Stomach, Forestomach|          X                                                               |             
      Intercostal, Lymphoma Malignant Mixed|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X        X           X     X     X              X                 X|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  21                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 1| 1| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 3| 3| 3| 2| 3| 3| 3|             
                                           | 9| 9| 9| 8| 3| 9| 9| 9| 9| 9| 3| 3| 1| 3| 9| 9| 9| 9| 0| 0| 0| 9| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6|             
    71HF                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                             X            |             
      Hemangioma                           |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
      Adenoma                              |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             | X  X        X  X                                   X  X        X         |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  22                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 5| 5| 5| 7| 7| 6|            |
                             DAY ON TEST   | 8| 3| 3| 3| 5| 2| 2| 2| 2| 2| 3| 3| 9| 6| 3| 3| 6| 3| 6| 9| 6| 3| 3| 2| 3|            |
                                           | 0| 0| 0| 0| 3| 9| 9| 9| 9| 9| 0| 0| 7| 2| 0| 0| 2| 0| 4| 6| 8| 8| 0| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    2.0%                                   | 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2|     L      |
    71HF                                   | 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  A  +  +  +|  44        |
      Lymphoma Malignant Mixed             | X                                   X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
      Lymphoma Malignant Mixed             |                                     X                                    |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
      Lymphoma Malignant Mixed             |       X                             X                                    |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Lymphoma Malignant Mixed             |       X                             X                                    |          3 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatoblastoma                       |                                                                          |          2 |
      Hepatocellular Carcinoma             |                   X              X     X                 X  X  X  X  X  X|         14 |
      Hepatocellular Carcinoma, Multiple   |       X                                   X  X     X  X                  |         13 |
      Hepatocellular Adenoma               |             X                                                            |          4 |
      Hepatocellular Adenoma, Multiple     | X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X|         45 |
      Lymphoma Malignant Mixed             | X                                   X                                    |          3 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                       X                  |          4 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +           +     +  +               |   8        |
      Lymphoma Malignant Mixed             |                                     X                                    |          1 |
      Sarcoma, Metastatic, Stomach,        |                                                                          |            |
          Forestomach                      |                                                          X               |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                       X                  |          3 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             | X                                   X                                    |          4 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|  47        |
      Parotid Gland, Lymphoma Malignant    |                                                                          |            |
          Mixed                            | X                                                                        |          1 |
      Sublingual Gland, Lymphoma Malignant |                                                                          |            |
          Mixed                            | X                                                                        |          1 |
      Submandibular Gland, Lymphoma        |                                                                          |            |
          Malignant Mixed                  | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  23                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 5| 5| 5| 7| 7| 6|            |
                             DAY ON TEST   | 8| 3| 3| 3| 5| 2| 2| 2| 2| 2| 3| 3| 9| 6| 3| 3| 6| 3| 6| 9| 6| 3| 3| 2| 3|            |
                                           | 0| 0| 0| 0| 3| 9| 9| 9| 9| 9| 0| 0| 7| 2| 0| 0| 2| 0| 4| 6| 8| 8| 0| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    2.0%                                   | 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2|     L      |
    71HF                                   | 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Sarcoma                              |                                                          X               |          1 |
      Squamous Cell Carcinoma              |                                                    X  X              X  X|         11 |
      Squamous Cell Papilloma              |                         X     X  X        X              X  X     X      |         13 |
      Squamous Cell Papilloma, Multiple    |    X     X     X  X                                X           X         |         14 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Sarcoma                              |                                                          X               |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                       X                  |          3 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Mixed             | X                                   X                                    |          2 |
      Squamous Cell Carcinoma, Metastatic  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  M  +  M  +  +  +  M  +  +  +  +  +  M  M  +  +  +  M  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  43        |
      Pars Distalis, Adenoma               |             X  X                                   X                     |          4 |
      Pars Nervosa, Adenoma                |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
      Follicular Cell, Adenoma             |                                                    X                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                       X                  |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  24                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 5| 5| 5| 7| 7| 6|            |
                             DAY ON TEST   | 8| 3| 3| 3| 5| 2| 2| 2| 2| 2| 3| 3| 9| 6| 3| 3| 6| 3| 6| 9| 6| 3| 3| 2| 3|            |
                                           | 0| 0| 0| 0| 3| 9| 9| 9| 9| 9| 0| 0| 7| 2| 0| 0| 2| 0| 4| 6| 8| 8| 0| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    2.0%                                   | 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2|     L      |
    71HF                                   | 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                       +        +  +                 +  +           +   |  12        |
      Axillary, Lymphoma Malignant Mixed   |                         X           X                                    |          2 |
      Bronchial, Lymphoma Malignant Mixed  | X                                                                        |          1 |
      Bronchial, Sarcoma, Metastatic,      |                                                                          |            |
          Stomach, Forestomach             |                                                          X               |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                     X                                    |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                         X           X                                    |          3 |
      Mediastinal, Lymphoma Malignant Mixed| X                                                                        |          1 |
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |            |
           Metastatic, Stomach, Forestomach|                                                       X                  |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                         X        X                                       |          4 |
      Renal, Lymphoma Malignant Mixed      |                                     X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  M  M  I  +  +  M  +  +  +  +  I  M  M  +  M  M  +  +  M  +  +|  31        |
      Lymphoma Malignant Mixed             | X                       X           X                                    |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +|  44        |
      Lymphoma Malignant Mixed             | X     X                 X           X                                    |          8 |
      Sarcoma, Metastatic, Stomach,        |                                                                          |            |
          Forestomach                      |                                                          X               |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             | X                    X  X           X                                    |          6 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  M  +  +  +  +  +  M  M  M  +  M  +  M  +  M  M  M  +  +  M  +|  34        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  +  M  +  M  M  +  +  M  M  +  M  M  +  +  +  M  M  +  +  M  M  M|  20        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Mixed                  | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  25                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7| 6| 5| 5| 5| 7| 7| 6|            |
                             DAY ON TEST   | 8| 3| 3| 3| 5| 2| 2| 2| 2| 2| 3| 3| 9| 6| 3| 3| 6| 3| 6| 9| 6| 3| 3| 2| 3|            |
                                           | 0| 0| 0| 0| 3| 9| 9| 9| 9| 9| 0| 0| 7| 2| 0| 0| 2| 0| 4| 6| 8| 8| 0| 4| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    2.0%                                   | 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2|     L      |
    71HF                                   | 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |   2        |
      Diaphragm, Squamous Cell Carcinoma,  |                                                                          |            |
           Metastatic, Stomach, Forestomach|                                                                          |          1 |
      Intercostal, Lymphoma Malignant Mixed| X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Adenoma         |                   X     X  X     X                             X         |         12 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                          X               |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                       X                  |          2 |
      Hemangioma                           |                                  X                                       |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                           X                              |          1 |
      Lymphoma Malignant Mixed             | X                                   X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                           +                              |   2        |
      Adenoma                              |                                           X                              |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             | X                                                                        |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             | X     X              X  X        X  X                                    |         13 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  26                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 5| 4| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 9| 3| 2| 2| 8| 9| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 1| 0| 0| 1| 2| 2| 3| 1| 0| 3| 1| 5| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6|             
    D 71UM                                 | 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                            X              X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
      Lymphoma Malignant Mixed             |                            X                                             |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                               X                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Multiple            |                                                                          |             
      Hepatocellular Carcinoma             |                   X     X                       X                    X   |             
      Hepatocellular Carcinoma, Multiple   |                X                                                         |             
      Hepatocellular Adenoma               |                            X                                   X         |             
      Hepatocellular Adenoma, Multiple     |       X                                                                  |             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                               X  X                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +              +                              |             
      Lymphoma Malignant Mixed             |                            X              X                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                            X              X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                  X                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submandibular Gland, Lymphoma        |                                                                          |             
          Malignant Mixed                  |                                           X                              |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                           X                              |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  27                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 5| 4| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 9| 3| 2| 2| 8| 9| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 1| 0| 0| 1| 2| 2| 3| 1| 0| 3| 1| 5| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6|             
    D 71UM                                 | 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                            X              X                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |    X                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  M  +  M  M  +  M  M  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  M  +  +  +  +  M  +  +  M  +  +  I  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                               +                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                            X              X                              |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +              +        +        M           +     +              +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                            X              X                              |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Preputial Gland                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                            X              X                              |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                            X              X                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sternal, Lymphoma Malignant          |                                                                          |             
          Histiocytic                      |                               X                                          |             
      Sternal, Lymphoma Malignant          |                                                                          |             
          Undifferentiated Cell Type       |                               X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                       +  +              +                              |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                            X              X                              |             
      Mediastinal, Lymphoma Malignant Mixed|                         X  X                                             |             
      Pancreatic, Lymphoma Malignant Mixed |                            X                                             |             
      Renal, Lymphoma Malignant Mixed      |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  M  +  +  M  +  M  M  +  +  +  +  +  +  M  M  M  +  M  M  +  M|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  28                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 5| 4| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 9| 3| 2| 2| 8| 9| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 1| 0| 0| 1| 2| 2| 3| 1| 0| 3| 1| 5| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6|             
    D 71UM                                 | 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                   X     X  X              X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                               X  X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                         X  X                                             |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                               X                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  M  M  M  M  +  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                            X              X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Squamous Cell Papilloma              |                         X                                                |             
      Subcutaneous Tissue, Fibroma         |             X     X                                                      |             
      Subcutaneous Tissue, Fibrosarcoma    |          X                                                               |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +              +                              |             
      Intercostal, Lymphoma Malignant Mixed|                            X              X                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X  X                                X        X                 X      |             
      Alveolar/Bronchiolar Carcinoma       |                   X                 X                                    |             
      Hepatocellular Carcinoma, Metastatic |                         X                                                |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                      X   |             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  29                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 5| 4| 3| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 9| 3| 2| 2| 8| 9| 3| 0| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 2| 1| 0| 0| 1| 2| 2| 3| 1| 0| 3| 1| 5| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATE                               | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6|             
    D 71UM                                 | 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                            X              X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                               X                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
      Adenoma                              |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
      Lymphoma Malignant Mixed             |                            X              X                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X              X     X  X              X                              |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                               X  X                                       |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  30                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 5| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 1| 2| 1| 1| 2| 2| 2| 1| 2| 2| 1| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    UNTREATE                               | 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2|     L      |
    D 71UM                                 | 4| 5| 2| 3| 4| 5| 1| 2| 3| 5| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|  46        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Polyp Adenomatous                    |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |    X                                                                     |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma, Multiple            |                X                                   X           X         |          3 |
      Hepatocellular Carcinoma             | X           X                                X              X            |          8 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                                  X     X                                 |          4 |
      Hepatocellular Adenoma, Multiple     |       X                    X                 X           X           X   |          6 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Submandibular Gland, Lymphoma        |                                                                          |            |
          Malignant Mixed                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  31                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 5| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 1| 2| 1| 1| 2| 2| 2| 1| 2| 2| 1| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    UNTREATE                               | 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2|     L      |
    D 71UM                                 | 4| 5| 2| 3| 4| 5| 1| 2| 3| 5| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                              +           +        +     +|   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  M  +  +  +  +  +  +  M  M  +  M  M  +  M  M  +  +  M  +  +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +                                   +        +     +  +         |  16        |
      Squamous Cell Carcinoma              |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|  47        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Preputial Gland                 |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Sternal, Lymphoma Malignant          |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  32                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 5| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 1| 2| 1| 1| 2| 2| 2| 1| 2| 2| 1| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    UNTREATE                               | 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2|     L      |
    D 71UM                                 | 4| 5| 2| 3| 4| 5| 1| 2| 3| 5| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Sternal, Lymphoma Malignant          |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                    +                                      +        +|   8        |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                         X|          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          2 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          2 |
      Pancreatic, Lymphoma Malignant Mixed |    X                                                                     |          2 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  M  +  +  +  M  M  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +|  32        |
      Lymphoma Malignant Lymphocytic       |                                                                         X|          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                         X|          1 |
      Lymphoma Malignant Mixed             |    X                          X                                          |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                         X|          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  I  +|  37        |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          2 |
      Subcutaneous Tissue, Fibrosarcoma    | X                                         X                              |          3 |
      Subcutaneous Tissue, Sarcoma         |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |    +                                                                     |   3        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  33                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 3| 5| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 1| 2| 1| 1| 2| 2| 2| 1| 2| 2| 1| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |
    UNTREATE                               | 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2|     L      |
    D 71UM                                 | 4| 5| 2| 3| 4| 5| 1| 2| 3| 5| 1| 3| 4| 5| 1| 3| 4| 1| 2| 3| 4| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Intercostal, Lymphoma Malignant Mixed|                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                   X                                   X                  |          7 |
      Alveolar/Bronchiolar Carcinoma       |       X                                                                  |          3 |
      Hepatocellular Carcinoma, Metastatic |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |             X                                                            |          2 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +|  43        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                     +                                    |   1        |
      Fibrosarcoma                         |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +                                          |   2        |
      Adenoma                              |                               X                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                         X|          1 |
      Lymphoma Malignant Mixed             |    X                          X                                          |          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  34                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 6| 5| 4| 7| 7| 7| 5| 7| 6| 6| 1|             
                             DAY ON TEST   | 2| 2| 7| 7| 0| 3| 3| 8| 1| 3| 3| 5| 3| 3| 1| 7| 5| 3| 3| 3| 8| 3| 4| 1| 5|             
                                           | 9| 9| 3| 3| 5| 0| 0| 9| 3| 0| 0| 4| 3| 0| 2| 2| 1| 0| 0| 0| 3| 0| 8| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mast Cell Tumor Malignant            |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Mast Cell Tumor Malignant            |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mast Cell Tumor Malignant            |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  M  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Mast Cell Tumor Malignant            |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Adenocarcinoma                       |    X                                                                     |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                                                                     |             
      Mast Cell Tumor Malignant            |       X                                                                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                X         |             
      Hepatoblastoma                       |                                              X                    X      |             
      Hepatocellular Carcinoma             |             X  X     X     X              X        X  X        X     X   |             
      Hepatocellular Carcinoma, Multiple   |                                                                   X      |             
      Hepatocellular Adenoma               |       X                             X           X           X     X      |             
      Hepatocellular Adenoma, Multiple     | X  X     X        X  X  X  X  X  X     X     X     X  X  X     X     X   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Tissue NOS                      |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |          X  X        X                                      X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +           +                    +              +            |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  35                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 6| 5| 4| 7| 7| 7| 5| 7| 6| 6| 1|             
                             DAY ON TEST   | 2| 2| 7| 7| 0| 3| 3| 8| 1| 3| 3| 5| 3| 3| 1| 7| 5| 3| 3| 3| 8| 3| 4| 1| 5|             
                                           | 9| 9| 3| 3| 5| 0| 0| 9| 3| 0| 0| 4| 3| 0| 2| 2| 1| 0| 0| 0| 3| 0| 8| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                         X                                   X            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                      X                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submandibular Gland, Lymphoma        |                                                                          |             
          Malignant Mixed                  |                X                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |                                                                          |             
      Mast Cell Tumor Malignant            |       X                                                                  |             
      Squamous Cell Carcinoma              | X  X  X  X  X        X  X                                   X            |             
      Squamous Cell Papilloma              | X  X  X        X  X     X              X           X  X        X         |             
      Squamous Cell Papilloma, Multiple    |                               X                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Mast Cell Tumor Malignant            |       X                                                                  |             
      Sarcoma                              |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |          X           X                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  M  +  M  +  +  M  +  +  +  +  M  +  +  +  +  M  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +|             
      Pars Distalis, Adenoma               |                            X                    X                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  36                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 6| 5| 4| 7| 7| 7| 5| 7| 6| 6| 1|             
                             DAY ON TEST   | 2| 2| 7| 7| 0| 3| 3| 8| 1| 3| 3| 5| 3| 3| 1| 7| 5| 3| 3| 3| 8| 3| 4| 1| 5|             
                                           | 9| 9| 3| 3| 5| 0| 0| 9| 3| 0| 0| 4| 3| 0| 2| 2| 1| 0| 0| 0| 3| 0| 8| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |          +                                                               |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |          X                                                               |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |          X                                                               |             
                                            __________________________________________________________________________|             
   Penis                                   |                               +                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                M                    +           +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                                         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                                         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Mast Cell Tumor Malignant            |                                                                          |             
      Sternal, Lymphoma Malignant Mixed    |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +     +                 +        +                 +            |             
      Inguinal, Lymphoma Malignant Mixed   |                X                                                         |             
      Lumbar, Histiocytic Sarcoma          |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                X                                                         |             
      Mediastinal, Histiocytic Sarcoma     |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                X                                                         |             
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Stomach, Forestomach|          X                                                  X            |             
      Pancreatic, Histiocytic Sarcoma      |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  37                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 6| 5| 4| 7| 7| 7| 5| 7| 6| 6| 1|             
                             DAY ON TEST   | 2| 2| 7| 7| 0| 3| 3| 8| 1| 3| 3| 5| 3| 3| 1| 7| 5| 3| 3| 3| 8| 3| 4| 1| 5|             
                                           | 9| 9| 3| 3| 5| 0| 0| 9| 3| 0| 0| 4| 3| 0| 2| 2| 1| 0| 0| 0| 3| 0| 8| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Renal, Histiocytic Sarcoma           |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  +  +  M  +  +  M  +  +  +  M  M  M  +  +  +  I  +  +  +  +  M  M  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Mast Cell Tumor Malignant            |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                           X                              |             
      Mast Cell Tumor Malignant            |       X                                                                  |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |             X                                               X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                X         |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                                      X                              |             
      Mast Cell Tumor Malignant            |       X                                                                  |             
      Mesothelioma Malignant               |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  +  +  M  M  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Mast Cell Tumor Malignant            |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Mast Cell Tumor Malignant            |       X                                                                  |             
      Squamous Cell Carcinoma              |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  38                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 6| 5| 4| 7| 7| 7| 5| 7| 6| 6| 1|             
                             DAY ON TEST   | 2| 2| 7| 7| 0| 3| 3| 8| 1| 3| 3| 5| 3| 3| 1| 7| 5| 3| 3| 3| 8| 3| 4| 1| 5|             
                                           | 9| 9| 3| 3| 5| 0| 0| 9| 3| 0| 0| 4| 3| 0| 2| 2| 1| 0| 0| 0| 3| 0| 8| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibroma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                     X                 X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
      Diaphragm, Sarcoma, Metastatic,      |                                                                          |             
          Stomach, Forestomach             |                                                                          |             
      Diaphragm, Squamous Cell Carcinoma,  |                                                                          |             
           Metastatic, Stomach, Forestomach|             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X  X           X  X     X  X     X           X     X  X  X  X      |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                            X                                             |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |       X                                                                  |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |          X  X        X                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                             +            |             
      Adenoma                              |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  39                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 6| 6| 7| 7| 6| 6| 7| 6| 5| 4| 7| 7| 7| 5| 7| 6| 6| 1|             
                             DAY ON TEST   | 2| 2| 7| 7| 0| 3| 3| 8| 1| 3| 3| 5| 3| 3| 1| 7| 5| 3| 3| 3| 8| 3| 4| 1| 5|             
                                           | 9| 9| 3| 3| 5| 0| 0| 9| 3| 0| 0| 4| 3| 0| 2| 2| 1| 0| 0| 0| 3| 0| 8| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    1.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 5| 1| 2| 4| 5| 1| 2| 4| 5| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Mast Cell Tumor Malignant            |       X                                                                  |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |          X  X                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Mast Cell Tumor Malignant            |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                                      X                              |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  40                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 0| 5| 3| 3| 1| 8| 7| 3| 3| 1| 1| 3| 3| 3| 3|             
                                           | 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 6| 0| 0| 0| 7| 2| 8| 0| 0| 5| 4| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  M  +  +     +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |             X                                                            |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Mast Cell Tumor Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Mast Cell Tumor Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mast Cell Tumor Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Mast Cell Tumor Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Mast Cell Tumor Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                             X            |             
      Hepatoblastoma                       |          X                                                               |             
      Hepatocellular Carcinoma             | X     X              X                                   X        X     X|             
      Hepatocellular Carcinoma, Multiple   |    X                                                                 X   |             
      Hepatocellular Adenoma               |                   X  X                 X                                 |             
      Hepatocellular Adenoma, Multiple     | X  X     X              X        X  X     X     X  X  X           X  X  X|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |             X                                                            |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Tissue NOS                      |             X                                                            |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                 +              +                           |             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  41                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 0| 5| 3| 3| 1| 8| 7| 3| 3| 1| 1| 3| 3| 3| 3|             
                                           | 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 6| 0| 0| 0| 7| 2| 8| 0| 0| 5| 4| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |             X                                                            |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |             X                                                            |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submandibular Gland, Lymphoma        |                                                                          |             
          Malignant Mixed                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyosarcoma                       |             X                                                            |             
      Mast Cell Tumor Malignant            |                                                                          |             
      Squamous Cell Carcinoma              |    X                                X     X  X                           |             
      Squamous Cell Papilloma              |                                           X                              |             
      Squamous Cell Papilloma, Multiple    |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Mast Cell Tumor Malignant            |                                                                          |             
      Sarcoma                              |             X                                                            |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X                                    |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |             X                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +     +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  42                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 0| 5| 3| 3| 1| 8| 7| 3| 3| 1| 1| 3| 3| 3| 3|             
                                           | 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 6| 0| 0| 0| 7| 2| 8| 0| 0| 5| 4| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |             +                                                            |             
      Squamous Cell Carcinoma              |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |             X                                                            |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     +           +                       +              +  +     +   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +     +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mast Cell Tumor Malignant            | X                                                                        |             
      Sternal, Lymphoma Malignant Mixed    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +                       +                                          |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Lumbar, Histiocytic Sarcoma          |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mediastinal, Histiocytic Sarcoma     |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Stomach, Forestomach|                                                                          |             
      Pancreatic, Histiocytic Sarcoma      |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  43                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 0| 5| 3| 3| 1| 8| 7| 3| 3| 1| 1| 3| 3| 3| 3|             
                                           | 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 6| 0| 0| 0| 7| 2| 8| 0| 0| 5| 4| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                               X                                          |             
      Renal, Histiocytic Sarcoma           |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |       X                                                                  |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  M  M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Mast Cell Tumor Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
      Lymphoma Malignant Mixed             |                      X                                                   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Mast Cell Tumor Malignant            |                                                                          |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |             X                                                            |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
      Lymphoma Malignant Mixed             |       X                                                                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Mast Cell Tumor Malignant            | X                                                                        |             
      Mesothelioma Malignant               |             X                                                            |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  M     +  +  +  +  M     +  +  +  +  M  +  +  M  M  +  +  +  M|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Mast Cell Tumor Malignant            | X                                                                        |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M     M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Mast Cell Tumor Malignant            |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  44                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 0| 5| 3| 3| 1| 8| 7| 3| 3| 1| 1| 3| 3| 3| 3|             
                                           | 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 6| 0| 0| 0| 7| 2| 8| 0| 0| 5| 4| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                   X           X                                          |             
      Subcutaneous Tissue, Fibroma,        |                                                                          |             
          Multiple                         |                      X                                                   |             
      Subcutaneous Tissue, Fibrosarcoma    |    X                 X     X     X           X  X                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                +                           |             
      Diaphragm, Sarcoma, Metastatic,      |                                                                          |             
          Stomach, Forestomach             |             X                                                            |             
      Diaphragm, Squamous Cell Carcinoma,  |                                                                          |             
           Metastatic, Stomach, Forestomach|                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X                 X        X              X  X              X     X   |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |       X  X                          X  X                          X      |             
      Alveolar/Bronchiolar Carcinoma       |                                        X                 X              X|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma, Metastatic, Stomach,        |                                                                          |             
          Forestomach                      |             X                                                            |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +                              |             
      Adenoma                              |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  45                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 7| 5| 7| 7| 7| 5| 5| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 0| 5| 3| 3| 1| 8| 7| 3| 3| 1| 1| 3| 3| 3| 3|             
                                           | 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 6| 0| 0| 0| 7| 2| 8| 0| 0| 5| 4| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    1.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4|             
    71LM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Mast Cell Tumor Malignant            |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Mast Cell Tumor Malignant            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                               X                                          |             
      Lymphoma Malignant Mixed             |       X              X                                                   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Mesothelioma Malignant               |             X                                                            |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  46                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 4|                                                                       |            |
                                           | 2|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   B6C3F1 MICE MALE                        | 0|                                                                       |     T      |
                               ANIMAL ID   | 2|                                                                       |     A      |
    1.0%                                   | 4|                                                                       |     L      |
    71LM                                   | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                                        |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +                                                                        |  47        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Sarcoma, Metastatic, Stomach,        |                                                                          |            |
          Forestomach                      |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                                        |  49        |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                                        |  51        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                                        |  50        |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                                        |  47        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                                        |  49        |
      Adenocarcinoma                       |                                                                          |          1 |
      Histiocytic Sarcoma                  | X                                                                        |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +                                                                        |  51        |
      Hemangiosarcoma                      |                                                                          |          2 |
      Hepatoblastoma                       |                                                                          |          3 |
      Hepatocellular Carcinoma             |                                                                          |         15 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          3 |
      Hepatocellular Adenoma               | X                                                                        |          9 |
      Hepatocellular Adenoma, Multiple     |                                                                          |         29 |
      Histiocytic Sarcoma                  | X                                                                        |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Sarcoma, Metastatic, Stomach,        |                                                                          |            |
          Forestomach                      |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  47                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 4|                                                                       |            |
                                           | 2|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   B6C3F1 MICE MALE                        | 0|                                                                       |     T      |
                               ANIMAL ID   | 2|                                                                       |     A      |
    1.0%                                   | 4|                                                                       |     L      |
    71LM                                   | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
           Tissue NOS                      |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Sarcoma, Metastatic, Stomach,        |                                                                          |            |
          Forestomach                      |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                                        |  50        |
      Histiocytic Sarcoma                  | X                                                                        |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Sarcoma, Metastatic, Stomach,        |                                                                          |            |
          Forestomach                      |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                                        |  51        |
      Submandibular Gland, Lymphoma        |                                                                          |            |
          Malignant Mixed                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                                                                        |  50        |
      Leiomyosarcoma                       |                                                                          |          1 |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |         12 |
      Squamous Cell Papilloma              |                                                                          |         11 |
      Squamous Cell Papilloma, Multiple    |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                                                                        |  50        |
      Histiocytic Sarcoma                  | X                                                                        |          1 |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                                        |  51        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +                                                                        |  51        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  48                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 4|                                                                       |            |
                                           | 2|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   B6C3F1 MICE MALE                        | 0|                                                                       |     T      |
                               ANIMAL ID   | 2|                                                                       |     A      |
    1.0%                                   | 4|                                                                       |     L      |
    71LM                                   | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                                                          |          1 |
      Sarcoma, Metastatic, Stomach,        |                                                                          |            |
          Forestomach                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +                                                                        |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M                                                                        |  37        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                                                                        |  45        |
      Pars Distalis, Adenoma               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                                                                        |  50        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +                                                                        |  51        |
      Histiocytic Sarcoma                  | X                                                                        |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Sarcoma, Metastatic, Stomach,        |                                                                          |            |
          Forestomach                      |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                                                                        |  16        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +                                                                        |  46        |
      Histiocytic Sarcoma                  | X                                                                        |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +                                                                        |  50        |
      Histiocytic Sarcoma                  | X                                                                        |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +                                                                        |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Sarcoma, Metastatic, Stomach,        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  49                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 4|                                                                       |            |
                                           | 2|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   B6C3F1 MICE MALE                        | 0|                                                                       |     T      |
                               ANIMAL ID   | 2|                                                                       |     A      |
    1.0%                                   | 4|                                                                       |     L      |
    71LM                                   | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Forestomach                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                                        |  50        |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
      Sternal, Lymphoma Malignant Mixed    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   8        |
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |          1 |
      Lumbar, Histiocytic Sarcoma          | X                                                                        |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Mediastinal, Histiocytic Sarcoma     | X                                                                        |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |            |
           Metastatic, Stomach, Forestomach|                                                                          |          2 |
      Pancreatic, Histiocytic Sarcoma      | X                                                                        |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Renal, Histiocytic Sarcoma           | X                                                                        |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +                                                                        |  34        |
      Histiocytic Sarcoma                  | X                                                                        |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |  47        |
      Histiocytic Sarcoma                  | X                                                                        |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
      Sarcoma, Metastatic, Stomach,        |                                                                          |            |
          Forestomach                      |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +                                                                        |  51        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Histiocytic Sarcoma                  | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  50                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 4|                                                                       |            |
                                           | 2|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   B6C3F1 MICE MALE                        | 0|                                                                       |     T      |
                               ANIMAL ID   | 2|                                                                       |     A      |
    1.0%                                   | 4|                                                                       |     L      |
    71LM                                   | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
      Mast Cell Tumor Malignant            |                                                                          |          2 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                                        |  35        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                                                        |  48        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          2 |
      Subcutaneous Tissue, Fibroma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          8 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                                        |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
      Diaphragm, Sarcoma, Metastatic,      |                                                                          |            |
          Stomach, Forestomach             |                                                                          |          1 |
      Diaphragm, Squamous Cell Carcinoma,  |                                                                          |            |
           Metastatic, Stomach, Forestomach|                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                                        |  51        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                                        |  51        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  51                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 4|                                                                       |            |
                                           | 2|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   B6C3F1 MICE MALE                        | 0|                                                                       |     T      |
                               ANIMAL ID   | 2|                                                                       |     A      |
    1.0%                                   | 4|                                                                       |     L      |
    71LM                                   | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar/Bronchiolar Adenoma         | X                                                                        |         20 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          6 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          3 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Histiocytic Sarcoma                  | X                                                                        |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Sarcoma, Metastatic, Stomach,        |                                                                          |            |
          Forestomach                      |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                                        |  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                                        |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Adenoma                              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                                        |  51        |
      Histiocytic Sarcoma                  | X                                                                        |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                                        |  50        |
      Histiocytic Sarcoma                  | X                                                                        |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Mast Cell Tumor Malignant            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +                                                                        |  51        |
      Histiocytic Sarcoma                  | X                                                                        |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  52                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6|                                                                       |            |
                             DAY ON TEST   | 4|                                                                       |            |
                                           | 2|                                                                       |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0|                                                                       |     O      |
   B6C3F1 MICE MALE                        | 0|                                                                       |     T      |
                               ANIMAL ID   | 2|                                                                       |     A      |
    1.0%                                   | 4|                                                                       |     L      |
    71LM                                   | 5|                                                                       |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  53                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 5| 4| 1| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 4| 9| 8| 3| 2| 2| 2| 2| 1| 2| 2| 8| 4| 2| 2| 2| 0| 2| 2| 2| 9|             
                                           | 9| 9| 9| 9| 8| 3| 4| 6| 9| 9| 9| 9| 3| 9| 9| 9| 5| 9| 9| 1| 6| 9| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|             
    2.0%                                   | 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|             
    71HM                                   | 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                   X                                                      |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Mixed             |                               X                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Stomach,   |                                                                          |             
           Forestomach                     |                                                                          |             
      Hemangiosarcoma                      |                   X                                                      |             
      Hepatoblastoma                       |                                                 X                        |             
      Hepatocellular Carcinoma             | X     X        X                          X     X        X  X     X      |             
      Hepatocellular Carcinoma, Multiple   |                         X        X                                   X   |             
      Hepatocellular Adenoma               |                         X                                            X   |             
      Hepatocellular Adenoma, Multiple     | X  X  X  X  X  X  X        X  X  X        X  X  X  X  X  X     X  X     X|             
      Hepatocholangiocarcinoma, Multiple   |                                                       X                  |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                            X                                             |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                   +|             
 _____________________________________________________________________________________________________________________|             

                                                             Page  54                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 5| 4| 1| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 4| 9| 8| 3| 2| 2| 2| 2| 1| 2| 2| 8| 4| 2| 2| 2| 0| 2| 2| 2| 9|             
                                           | 9| 9| 9| 9| 8| 3| 4| 6| 9| 9| 9| 9| 3| 9| 9| 9| 5| 9| 9| 1| 6| 9| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|             
    2.0%                                   | 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|             
    71HM                                   | 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                             X            |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              | X              X                 X  X                                   X|             
      Squamous Cell Papilloma              |                         X     X                    X  X  X     X     X   |             
      Squamous Cell Papilloma, Multiple    |          X                 X                                X            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                         X|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +        +                          +  +                                 |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                 X                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  M  +  M  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Stomach,   |                                                                          |             
           Forestomach                     |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  55                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 5| 4| 1| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 4| 9| 8| 3| 2| 2| 2| 2| 1| 2| 2| 8| 4| 2| 2| 2| 0| 2| 2| 2| 9|             
                                           | 9| 9| 9| 9| 8| 3| 4| 6| 9| 9| 9| 9| 3| 9| 9| 9| 5| 9| 9| 1| 6| 9| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|             
    2.0%                                   | 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|             
    71HM                                   | 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |          +                                                               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +                    +  +                    +           +  +         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Fibrosarcoma, Metastatic, Stomach,   |                                                                          |             
           Forestomach                     |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach, Forestomach            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                            X                                             |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +     +        +                       +           +|             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |             
           Metastatic, Stomach, Forestomach|                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                            X                                X            |             
      Pancreatic, Squamous Cell Carcinoma, |                                                                          |             
           Metastatic, Stomach, Forestomach|                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  M  +  M  M  M  +  M  +  +  M  M  +  M  +  +  M  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                            X                                             |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  +  M  M  +  +  +  +  +  +  +  +  M  +  I  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  56                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 5| 4| 1| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 4| 9| 8| 3| 2| 2| 2| 2| 1| 2| 2| 8| 4| 2| 2| 2| 0| 2| 2| 2| 9|             
                                           | 9| 9| 9| 9| 8| 3| 4| 6| 9| 9| 9| 9| 3| 9| 9| 9| 5| 9| 9| 1| 6| 9| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|             
    2.0%                                   | 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|             
    71HM                                   | 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                     +                                    |             
      Abdominal, Squamous Cell Carcinoma,  |                                                                          |             
           Metastatic, Stomach, Forestomach|                                                                          |             
      Diaphragm, Squamous Cell Carcinoma,  |                                                                          |             
           Metastatic, Stomach, Forestomach|                                                                          |             
      Intercostal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X           X  X        X           X              X  X  X     X      |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |          X                                      X  X                 X  X|             
      Alveolar/Bronchiolar Carcinoma       |             X                                                            |             
      Hepatocellular Carcinoma, Metastatic |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Mediastinum, Hemangiosarcoma,        |                                                                          |             
          Metastatic, Spleen               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                          |             
      Adenoma                              |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  57                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 5| 4| 1| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 4| 9| 8| 3| 2| 2| 2| 2| 1| 2| 2| 8| 4| 2| 2| 2| 0| 2| 2| 2| 9|             
                                           | 9| 9| 9| 9| 8| 3| 4| 6| 9| 9| 9| 9| 3| 9| 9| 9| 5| 9| 9| 1| 6| 9| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|             
    2.0%                                   | 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0|             
    71HM                                   | 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4| 5| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                            X  X                             X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  58                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 6| 6| 2| 7| 7| 6| 5| 6| 2| 1| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 1| 4| 2| 2| 3| 1| 8| 4| 0| 2| 2| 2| 1|            |
                                           | 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 5| 8| 8| 9| 4| 3| 2| 9| 9| 9| 9| 9| 2| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6|     L      |
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 4| 5| 1| 2| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  A  +  +  +  M|  42        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +|  46        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Lymphoma Malignant Mixed             |                   X                                                      |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
      Adenocarcinoma                       |                                  X           X                           |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Stomach,   |                                                                          |            |
           Forestomach                     |             X                                                            |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatoblastoma                       | X     X                                         X     X                  |          5 |
      Hepatocellular Carcinoma             |                         X  X                          X                 X|         12 |
      Hepatocellular Carcinoma, Multiple   |    X                          X  X           X                 X     X   |          9 |
      Hepatocellular Adenoma               |             X           X  X  X     X                                   X|          8 |
      Hepatocellular Adenoma, Multiple     | X     X  X        X  X           X        X  X  X              X  X  X   |         31 |
      Hepatocholangiocarcinoma, Multiple   |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                       X                  |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  59                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 6| 6| 2| 7| 7| 6| 5| 6| 2| 1| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 1| 4| 2| 2| 3| 1| 8| 4| 0| 2| 2| 2| 1|            |
                                           | 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 5| 8| 8| 9| 4| 3| 2| 9| 9| 9| 9| 9| 2| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6|     L      |
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 4| 5| 1| 2| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                         X        X           X                       X   |          4 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +              +        +     +     +                 +     +   |   9        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |          X              X        X           X                       X   |          5 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Mixed             |                   X                                                      |          2 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Carcinoma              |          X  X           X        X  X     X  X                       X   |         13 |
      Squamous Cell Papilloma              |                   X                       X                          X  X|         11 |
      Squamous Cell Papilloma, Multiple    |                               X                                X         |          5 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |          X              X                                            X   |          4 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                        +                                 |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                         +  +   |   7        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  M  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +|  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      C-Cell, Adenoma                      |                                                                   X      |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  60                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 6| 6| 2| 7| 7| 6| 5| 6| 2| 1| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 1| 4| 2| 2| 3| 1| 8| 4| 0| 2| 2| 2| 1|            |
                                           | 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 5| 8| 8| 9| 4| 3| 2| 9| 9| 9| 9| 9| 2| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6|     L      |
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 4| 5| 1| 2| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                      +   |   1        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Stomach,   |                                                                          |            |
           Forestomach                     |             X                                                            |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                               +                                          |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    M                 +              +           +              +  +  +   |  12        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  M  +     +  +  +  +  +  +  +|  45        |
      Fibrosarcoma, Metastatic, Stomach,   |                                                                          |            |
           Forestomach                     |             X                                                            |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach, Forestomach            |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +        +              +                             +  +  +   |  11        |
      Lumbar, Lymphoma Malignant Mixed     |                   X                                                      |          1 |
      Mediastinal, Squamous Cell Carcinoma,|                                                                          |            |
           Metastatic, Stomach, Forestomach|                                  X                                       |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                   X                                               X      |          4 |
      Pancreatic, Squamous Cell Carcinoma, |                                                                          |            |
           Metastatic, Stomach, Forestomach|          X                                                               |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  61                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 6| 6| 2| 7| 7| 6| 5| 6| 2| 1| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 1| 4| 2| 2| 3| 1| 8| 4| 0| 2| 2| 2| 1|            |
                                           | 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 5| 8| 8| 9| 4| 3| 2| 9| 9| 9| 9| 9| 2| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6|     L      |
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 4| 5| 1| 2| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  I  M  M  M  M  M  +  M  M  +  +  +  +  +  +  M  +  M  M  M  +  M  +  +|  26        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +|  47        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                X                                                         |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +  +  M  M  +  M  M  +  +  +  +  +  M  M  +  M  +  +  +  +  M  +|  33        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Subcutaneous Tissue, Fibroma         |                                                                      X   |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                     X                                    |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +                                   +   |   3        |
      Abdominal, Squamous Cell Carcinoma,  |                                                                          |            |
           Metastatic, Stomach, Forestomach|                                  X                                   X   |          2 |
      Diaphragm, Squamous Cell Carcinoma,  |                                                                          |            |
           Metastatic, Stomach, Forestomach|                                                                      X   |          1 |
      Intercostal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |          X  X           X        X     X                          X      |         15 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |    X                 X                    X                    X         |          9 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  62                                                               
NTP Experiment-Test: 05061-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  1-AMINO-2,4-DIBROMOANTHRAQUINONE                             Date: 04/03/97  
Route: DOSED FEED                                                                                                 Time: 13:30:59  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 6| 6| 2| 7| 7| 6| 5| 6| 2| 1| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 1| 4| 2| 2| 3| 1| 8| 4| 0| 2| 2| 2| 1|            |
                                           | 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 5| 8| 8| 9| 4| 3| 2| 9| 9| 9| 9| 9| 2| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |
    2.0%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6|     L      |
    71HM                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 3| 4| 5| 1| 4| 5| 1| 2| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic |                            X                 X                           |          2 |
      Histiocytic Sarcoma                  |                                                       X                  |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
      Mediastinum, Hemangiosarcoma,        |                                                                          |            |
          Metastatic, Spleen               |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                       X                  |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                   X                                               X      |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  63                                                               
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