TR 383 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
1-AMINO-2,4-DIBROMOANTHRAQUINONE
NTP Experiment-Test: 05061-02 Report: PEIRPT03
Study Type: CHRONIC Date: 05/19/95
Route: DOSED FEED Time: 16:49:58
Facility: TSI Mason Research
Chemical CAS #: 81-49-2
Lock Date: 03/25/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05061-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 16:49:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATE 1.0% 2.0%
D 71UF 71LF 71HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 5 11 11
Dead 6 5 6
Survivors
Terminal Sacrifice 38 33 33
Moribund 1
Dead 1
Animals Examined Microscopically 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (55) (57)
Autolysis 1 (2%)
Gallbladder (59) (57) (54)
Autolysis 3 (5%) 2 (4%) 2 (4%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Chronic Active 6 (10%) 6 (11%) 8 (15%)
Epithelium, Hyperplasia 1 (2%)
Intestine Large, Colon (60) (60) (58)
Autolysis 3 (5%) 1 (2%)
Inflammation, Acute 1 (2%)
Peyer's Patch, Hyperplasia 1 (2%) 1 (2%)
Intestine Large, Rectum (60) (60) (57)
Autolysis 2 (3%) 1 (2%)
Peyer's Patch, Epithelium, Proliferation 1 (2%)
Intestine Large, Cecum (60) (59) (57)
Autolysis 4 (7%) 1 (2%)
Peyer's Patch, Hyperplasia 1 (2%) 2 (3%)
Intestine Small, Duodenum (58) (60) (56)
Angiectasis 1 (2%)
Autolysis 2 (3%) 2 (3%) 2 (4%)
Intestine Small, Jejunum (57) (60) (56)
Autolysis 1 (2%) 2 (3%) 2 (4%)
Peyer's Patch, Hyperplasia 2 (4%)
Intestine Small, Ileum (58) (60) (56)
Autolysis 2 (3%) 2 (3%) 2 (4%)
Inflammation, Acute 1 (2%)
Peyer's Patch, Hyperplasia 4 (7%) 3 (5%) 1 (2%)
Peyer's Patch, Inflammation, Acute 1 (2%)
Liver (60) (60) (60)
Autolysis 2 (3%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05061-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 16:49:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATE 1.0% 2.0%
D 71UF 71LF 71HF
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Basophilic Focus 5 (8%) 6 (10%)
Clear Cell Focus 10 (17%) 9 (15%)
Eosinophilic Focus 4 (7%) 2 (3%)
Fatty Change 3 (5%) 4 (7%) 18 (30%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 3 (5%) 6 (10%) 6 (10%)
Hemorrhage 1 (2%)
Inflammation, Acute 5 (8%) 4 (7%)
Inflammation, Chronic Active 36 (60%) 28 (47%) 29 (48%)
Mixed Cell Focus 2 (3%)
Necrosis, Coagulative 16 (27%) 26 (43%) 25 (42%)
Pigmentation 54 (90%) 58 (97%)
Bile Duct, Hyperplasia 1 (2%)
Bile Duct, Hyperplasia, Focal 1 (2%)
Mesentery (6) (9) (8)
Fibrosis 4 (44%)
Inflammation, Chronic Active 3 (50%) 5 (56%) 4 (50%)
Mineralization 1 (17%)
Necrosis, Coagulative 1 (17%) 3 (33%)
Pigmentation 1 (17%)
Pancreas (60) (60) (59)
Atrophy 1 (2%) 2 (3%)
Autolysis 2 (3%)
Cytoplasmic Alteration 3 (5%) 1 (2%)
Fibrosis 1 (2%)
Inflammation 1 (2%)
Inflammation, Chronic 5 (8%) 1 (2%)
Inflammation, Chronic Active 25 (42%) 24 (40%) 18 (31%)
Vacuolization Cytoplasmic 20 (33%) 13 (22%) 21 (36%)
Duct, Dilatation 1 (2%) 1 (2%) 1 (2%)
Duct, Hyperplasia 1 (2%)
Salivary Glands (59) (60) (57)
Inflammation, Chronic 1 (2%) 5 (9%)
Parotid Gland, Autolysis 1 (2%)
Sublingual Gland, Inflammation, Chronic 1 (2%) 2 (3%)
Submandibular Gland, Autolysis 1 (2%)
Submandibular Gland, Inflammation, Chronic 47 (80%) 32 (53%) 33 (58%)
Stomach, Forestomach (58) (60) (60)
Acanthosis 9 (16%) 16 (27%) 27 (45%)
Autolysis 1 (2%)
Erosion 1 (2%) 1 (2%)
Hyperkeratosis 10 (17%) 16 (27%) 24 (40%)
Hyperplasia, Basal Cell 7 (12%) 5 (8%)
Hyperplasia, Squamous 2 (3%)
Inflammation, Chronic 2 (3%)
Inflammation, Chronic Active 7 (12%) 11 (18%) 24 (40%)
Ulcer 2 (3%) 1 (2%) 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05061-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 16:49:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATE 1.0% 2.0%
D 71UF 71LF 71HF
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Ulcer, Multiple 1 (2%)
Stomach, Glandular (59) (58) (58)
Autolysis 2 (3%) 1 (2%)
Inflammation, Chronic 2 (3%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 21 (36%) 19 (33%) 21 (36%)
Mineralization 1 (2%) 1 (2%)
Tooth (1)
Abscess 1 (100%)
Dysplasia 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (59)
Autolysis 1 (2%)
Cardiomyopathy 2 (3%)
Inflammation, Chronic 9 (15%) 6 (10%) 8 (14%)
Mineralization 1 (2%) 1 (2%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (59) (58)
Angiectasis 2 (3%)
Autolysis 1 (2%)
Cyst 1 (2%)
Degeneration, Fatty 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 3 (5%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Chronic Active 2 (3%) 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Adrenal Medulla (59) (59) (58)
Autolysis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Islets, Pancreatic (49) (50) (48)
Hyperplasia 3 (6%) 1 (2%) 1 (2%)
Parathyroid Gland (43) (49) (43)
Cyst 1 (2%)
Pituitary Gland (51) (55) (52)
Autolysis 1 (2%)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Cyst 3 (6%) 1 (2%)
Pars Distalis, Hyperplasia 8 (16%) 22 (40%) 8 (15%)
Pars Distalis, Pigmentation 1 (2%)
Thyroid Gland (60) (60) (58)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05061-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 16:49:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATE 1.0% 2.0%
D 71UF 71LF 71HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Autolysis 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (3%) 3 (5%)
C-Cell, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Follicle, Cyst 2 (3%) 2 (3%)
Follicular Cell, Hyperplasia 3 (5%) 19 (32%) 18 (31%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (1)
Duct, Dilatation 1 (100%)
Ovary (59) (51) (57)
Abscess 3 (6%) 2 (4%)
Angiectasis 2 (3%) 4 (8%) 4 (7%)
Cyst 13 (22%) 12 (24%) 9 (16%)
Cyst, Multiple 1 (2%) 3 (6%) 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Acute, Necrotizing 1 (2%)
Mineralization 2 (4%)
Pigmentation 1 (2%)
Periovarian Tissue, Cyst 1 (2%) 2 (4%)
Periovarian Tissue, Cyst, Multiple 1 (2%)
Periovarian Tissue, Hemorrhage 1 (2%)
Periovarian Tissue, Inflammation, Chronic 2 (3%)
Periovarian Tissue, Inflammation, Chronic
Active 29 (49%) 24 (47%) 28 (49%)
Periovarian Tissue, Mineralization 1 (2%)
Periovarian Tissue, Pigmentation 1 (2%)
Uterus (59) (60) (59)
Angiectasis 1 (2%)
Fibrosis 2 (3%) 1 (2%)
Hydrometra 22 (37%) 3 (5%) 3 (5%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 4 (7%) 6 (10%) 7 (12%)
Endometrium, Hyperplasia 44 (75%) 36 (60%) 45 (76%)
Epithelium, Metaplasia, Squamous 2 (3%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05061-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 16:49:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATE 1.0% 2.0%
D 71UF 71LF 71HF
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (59) (59)
Myelofibrosis 2 (3%) 5 (8%) 1 (2%)
Myeloid Cell, Sternal, Hyperplasia 2 (3%) 1 (2%) 2 (3%)
Sternal, Autolysis 1 (2%)
Sternal, Myelofibrosis 38 (63%) 32 (54%) 34 (58%)
Lymph Node (7) (12) (12)
Lumbar, Hyperplasia, Lymphoid 1 (14%) 1 (8%)
Lumbar, Inflammation, Acute 1 (14%)
Mediastinal, Hyperplasia, Lymphoid 1 (8%)
Mediastinal, Hyperplasia, Plasma Cell 1 (8%)
Mediastinal, Inflammation, Chronic Active 1 (14%)
Pancreatic, Hyperplasia, Lymphoid 1 (8%) 1 (8%)
Pancreatic, Infiltration Cellular, Histiocyte 1 (8%)
Pancreatic, Pigmentation 1 (8%)
Renal, Hyperplasia, Plasma Cell 2 (17%)
Renal, Sinus, Ectasia 1 (8%)
Lymph Node, Mandibular (38) (55) (41)
Autolysis 1 (2%)
Congestion 1 (3%)
Depletion Lymphoid 1 (2%)
Hyperplasia, Lymphoid 3 (8%) 1 (2%) 2 (5%)
Hyperplasia, Plasma Cell 1 (3%) 1 (2%)
Inflammation, Acute 1 (2%)
Pigmentation 3 (8%) 2 (4%) 3 (7%)
Sinus, Ectasia 2 (4%)
Lymph Node, Mesenteric (56) (56) (52)
Angiectasis 7 (13%) 4 (7%) 3 (6%)
Depletion Lymphoid 2 (4%) 1 (2%)
Hemorrhage 2 (4%)
Hyperplasia, Lymphoid 2 (4%) 6 (11%) 10 (19%)
Infiltration Cellular, Histiocyte 36 (64%) 24 (43%) 34 (65%)
Inflammation, Chronic Active 1 (2%) 3 (5%) 2 (4%)
Mineralization 1 (2%)
Necrosis, Coagulative 1 (2%)
Pigmentation 34 (61%) 24 (43%) 34 (65%)
Sinus, Ectasia 1 (2%)
Spleen (60) (60) (59)
Autolysis 1 (2%) 1 (2%)
Depletion Lymphoid 4 (7%) 2 (3%) 3 (5%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 6 (10%) 13 (22%) 11 (19%)
Hyperplasia, Lymphoid 15 (25%) 14 (23%) 8 (14%)
Inflammation, Chronic 1 (2%)
Thymus (49) (48) (42)
Angiectasis 1 (2%)
Cyst 20 (41%) 16 (33%) 28 (67%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05061-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 16:49:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATE 1.0% 2.0%
D 71UF 71LF 71HF
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Depletion Lymphoid 4 (8%) 2 (4%) 6 (14%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 3 (6%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (35) (35) (30)
Hyperplasia 2 (6%) 9 (26%) 3 (10%)
Inflammation, Chronic 1 (3%)
Skin (60) (60) (60)
Acanthosis 1 (2%)
Autolysis 1 (2%)
Inflammation, Acute 1 (2%)
Epidermis, Inflammation, Acute 1 (2%)
Subcutaneous Tissue, Cyst Epithelial
Inclusion 1 (2%)
Subcutaneous Tissue, Fibrosis 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (2%) 2 (3%) 2 (3%)
Subcutaneous Tissue, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (59) (60) (60)
Perivascular, Inflammation, Chronic 1 (2%)
Thalamus, Mineralization 24 (41%) 15 (25%) 25 (42%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (59)
Autolysis 1 (2%)
Congestion 1 (2%)
Hemorrhage 4 (7%) 4 (7%) 8 (14%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Chronic Active 3 (5%) 4 (7%) 6 (10%)
Leukocytosis 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%)
Pleura, Inflammation, Acute 1 (2%)
Nose (58) (55) (53)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05061-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 16:49:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATE 1.0% 2.0%
D 71UF 71LF 71HF
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Acute 21 (36%) 9 (16%) 7 (13%)
Glands, Inflammation, Acute 2 (3%) 1 (2%)
Nasolacrimal Duct, Hyperplasia 1 (2%)
Nasolacrimal Duct, Inflammation, Acute 1 (2%)
Trachea (60) (59) (57)
Autolysis 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Cornea, Inflammation, Chronic Active 1 (100%)
Cornea, Neovascularization 1 (100%)
Harderian Gland (1) (3) (2)
Inflammation, Chronic 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (54) (60)
Autolysis 1 (2%)
Glomerulosclerosis 2 (3%) 3 (6%) 4 (7%)
Hydronephrosis 1 (2%) 1 (2%)
Infarct 1 (2%)
Inflammation, Chronic 53 (88%) 46 (85%) 54 (90%)
Metaplasia, Osseous 3 (6%) 1 (2%)
Papilla, Mineralization 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%)
Proximal Convoluted Renal Tubule,
Degeneration, Hyaline 1 (2%)
Renal Tubule, Atrophy 1 (2%) 3 (5%)
Renal Tubule, Casts Protein 1 (2%)
Renal Tubule, Mineralization 3 (5%)
Renal Tubule, Pigmentation 43 (80%) 43 (72%)
Renal Tubule, Regeneration 3 (5%) 7 (13%) 4 (7%)
Transitional Epithelium, Mineralization 1 (2%)
Urinary Bladder (59) (60) (60)
Autolysis 3 (5%) 1 (2%) 2 (3%)
Inflammation, Chronic 7 (12%) 7 (12%) 8 (13%)
Inflammation, Chronic Active 42 (71%) 43 (72%) 46 (77%)
Arteriole, Necrosis, Fibrinoid 1 (2%)
Submucosa, Proliferation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05061-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 16:49:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATE 1.0% 2.0%
D 71UM 71LM 71HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 10 9 10
Early Deaths
Moribund 7 23 21
Dead 3 5 6
Accident 1
Survivors
Terminal Sacrifice 40 22 23
Animals Examined Microscopically 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (56) (56) (51)
Autolysis 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 12 (21%) 12 (21%) 8 (16%)
Epithelium, Pigmentation 1 (2%)
Intestine Large, Colon (60) (58) (60)
Autolysis 1 (2%) 2 (3%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (3%)
Peyer's Patch, Hyperplasia 1 (2%)
Intestine Large, Rectum (58) (58) (58)
Autolysis 2 (3%) 2 (3%)
Intestine Large, Cecum (59) (60) (60)
Autolysis 2 (3%) 2 (3%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Ulcer, Acute 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Peyer's Patch, Hyperplasia 1 (2%) 1 (2%)
Serosa, Inflammation, Chronic Active 1 (2%)
Intestine Small, Duodenum (60) (59) (56)
Autolysis 2 (3%) 1 (2%)
Mesothelium, Hyperplasia 1 (2%)
Peyer's Patch, Inflammation, Chronic,
Granulomatous 1 (2%)
Serosa, Fibrosis 1 (2%)
Intestine Small, Jejunum (60) (56) (58)
Autolysis 2 (3%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Acute 1 (2%)
Epithelium, Pigmentation 1 (2%)
Peyer's Patch, Inflammation, Chronic,
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05061-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 16:49:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATE 1.0% 2.0%
D 71UM 71LM 71HM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Granulomatous 1 (2%)
Intestine Small, Ileum (60) (58) (57)
Autolysis 2 (3%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Acute, Necrotizing 1 (2%)
Inflammation, Chronic Active 1 (2%)
Peyer's Patch, Hyperplasia 1 (2%) 2 (3%) 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Peyer's Patch, Inflammation, Chronic,
Granulomatous 1 (2%)
Liver (60) (60) (60)
Angiectasis 1 (2%)
Basophilic Focus 4 (7%) 4 (7%)
Basophilic Focus, Focal 1 (2%)
Clear Cell Focus 4 (7%) 4 (7%) 2 (3%)
Cytoplasmic Alteration 1 (2%)
Eosinophilic Focus 6 (10%) 1 (2%)
Fatty Change 11 (18%) 6 (10%) 7 (12%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 5 (8%) 10 (17%)
Infarct 1 (2%)
Inflammation, Acute 1 (2%) 9 (15%) 3 (5%)
Inflammation, Chronic Active 15 (25%) 10 (17%) 27 (45%)
Karyomegaly 1 (2%)
Mineralization 1 (2%) 1 (2%)
Necrosis, Coagulative 9 (15%) 20 (33%) 28 (47%)
Nuclear Alteration 1 (2%)
Pigmentation 1 (2%) 59 (98%) 57 (95%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 1 (2%) 2 (3%) 1 (2%)
Centrilobular, Cytoplasmic Alteration 9 (15%) 8 (13%)
Hepatocyte, Centrilobular, Hypertrophy 17 (28%) 13 (22%)
Mesentery (2) (8) (9)
Abscess 1 (11%)
Fibrosis 1 (11%)
Inflammation, Chronic 1 (13%)
Inflammation, Chronic Active 4 (50%) 5 (56%)
Mineralization 1 (11%)
Necrosis, Coagulative 1 (13%) 2 (22%)
Thrombosis 1 (13%)
Pancreas (60) (59) (58)
Atrophy 2 (3%) 1 (2%)
Autolysis 1 (2%) 1 (2%)
Cytoplasmic Alteration 4 (7%) 2 (3%)
Ectopic Liver 1 (2%)
Inflammation, Chronic 2 (3%)
Inflammation, Chronic Active 19 (32%) 12 (20%) 8 (14%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05061-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 16:49:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATE 1.0% 2.0%
D 71UM 71LM 71HM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Vacuolization Cytoplasmic 20 (33%) 18 (31%) 4 (7%)
Acinus, Atrophy 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Salivary Glands (60) (59) (60)
Inflammation, Chronic 2 (3%)
Duct, Parotid Gland, Mineralization 1 (2%)
Parotid Gland, Inflammation, Chronic 2 (3%)
Sublingual Gland, Inflammation, Chronic 1 (2%)
Sublingual Gland, Submandibular Gland,
Inflammation, Chronic 1 (2%)
Submandibular Gland, Atrophy 1 (2%)
Submandibular Gland, Inflammation, Chronic 45 (75%) 29 (49%) 40 (67%)
Stomach, Forestomach (59) (59) (60)
Abscess 1 (2%)
Acanthosis 1 (2%) 11 (19%) 7 (12%)
Autolysis 1 (2%)
Cyst 1 (2%)
Diverticulum 1 (2%)
Edema 1 (2%)
Erosion 1 (2%)
Hyperkeratosis 2 (3%) 9 (15%) 9 (15%)
Hyperplasia, Basal Cell 1 (2%) 3 (5%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 2 (3%) 6 (10%) 14 (23%)
Inflammation, Chronic Active, Necrotizing 1 (2%)
Ulcer 2 (3%)
Stomach, Glandular (59) (59) (59)
Autolysis 1 (2%)
Edema 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Chronic 1 (2%) 5 (8%) 2 (3%)
Inflammation, Chronic Active 15 (25%) 24 (41%) 23 (39%)
Mineralization 4 (7%) 3 (5%)
Muscularis, Mineralization 1 (2%)
Tooth (4) (7)
Dysplasia 4 (100%) 6 (86%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60)
Cardiomyopathy 3 (5%) 1 (2%)
Inflammation, Chronic 7 (12%) 17 (28%) 5 (8%)
Mineralization 1 (2%)
Necrosis, Coagulative 1 (2%)
Coronary Artery, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05061-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 16:49:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATE 1.0% 2.0%
D 71UM 71LM 71HM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 3 (5%) 2 (3%)
Inflammation, Chronic Active 3 (5%)
Pigmentation 2 (3%)
Vacuolization Cytoplasmic 1 (2%)
Capsule, Inflammation, Chronic Active 1 (2%)
Adrenal Medulla (60) (59) (60)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%)
Pigmentation 1 (2%)
Islets, Pancreatic (51) (50) (49)
Hyperplasia 9 (18%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Pituitary Gland (52) (54) (56)
Pars Distalis, Cyst 5 (10%) 4 (7%) 1 (2%)
Pars Distalis, Hyperplasia 13 (25%) 9 (17%) 6 (11%)
Thyroid Gland (59) (59) (59)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Ultimobranchial Cyst 1 (2%) 1 (2%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 2 (3%) 3 (5%) 3 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1) (1) (1)
Inflammation, Chronic Active 1 (100%)
Epididymis (59) (60) (60)
Inflammation, Chronic Active 30 (51%) 21 (35%) 26 (43%)
Epithelium, Hyperplasia 1 (2%)
Serosa, Hyperplasia 1 (2%)
Penis (1) (1) (2)
Hemorrhage 1 (100%)
Inflammation, Acute 1 (100%)
Preputial Gland (21) (16) (13)
Abscess 1 (5%) 3 (19%) 2 (15%)
Inflammation, Chronic 2 (10%)
Inflammation, Chronic Active 14 (67%) 7 (44%) 11 (85%)
Duct, Dilatation 12 (57%) 10 (63%) 2 (15%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05061-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 16:49:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATE 1.0% 2.0%
D 71UM 71LM 71HM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Prostate (57) (55) (57)
Inflammation 1 (2%)
Inflammation, Chronic 5 (9%) 2 (4%)
Inflammation, Chronic Active 32 (56%) 29 (53%) 20 (35%)
Artery, Inflammation, Chronic Active 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Seminal Vesicle (59) (59) (55)
Atrophy 1 (2%) 1 (2%)
Cyst 1 (2%)
Fibrosis 3 (5%)
Inflammation, Chronic Active 4 (7%) 14 (24%) 13 (24%)
Artery, Thrombosis 1 (2%)
Testes (60) (59) (60)
Atrophy 2 (3%)
Inflammation, Chronic Active 2 (3%)
Interstitial Cell, Hyperplasia 1 (2%)
Seminiferous Tubule, Atrophy 7 (12%) 4 (7%)
Seminiferous Tubule, Mineralization 2 (3%) 1 (2%) 3 (5%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (59) (59)
Myeloid Cell, Sternal, Hyperplasia 1 (2%) 2 (3%) 1 (2%)
Sternal, Infiltration Cellular, Mast Cell 1 (2%)
Sternal, Inflammation, Granulomatous 1 (2%)
Lymph Node (10) (8) (11)
Hyperplasia, Lymphoid 1 (9%)
Inguinal, Hyperplasia, Lymphoid 1 (10%)
Lumbar, Hyperplasia 1 (10%)
Lumbar, Hyperplasia, Lymphoid 1 (10%) 1 (13%)
Lumbar, Hyperplasia, Plasma Cell 2 (18%)
Lumbar, Inflammation, Chronic Active 1 (13%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (13%)
Mediastinal, Inflammation, Chronic Active 1 (9%)
Mediastinal, Pigmentation 1 (13%)
Pancreatic, Angiectasis 1 (9%)
Pancreatic, Hyperplasia, Lymphoid 2 (20%)
Pancreatic, Infiltration Cellular, Histiocyte 1 (10%)
Pancreatic, Pigmentation 1 (10%)
Renal, Angiectasis 1 (10%)
Renal, Hyperplasia, Lymphoid 1 (10%)
Renal, Inflammation, Chronic Active 1 (13%)
Lymph Node, Mandibular (38) (43) (36)
Depletion Lymphoid 3 (8%) 1 (2%) 1 (3%)
Hyperplasia, Lymphoid 3 (8%) 1 (2%) 1 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05061-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 16:49:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATE 1.0% 2.0%
D 71UM 71LM 71HM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Plasma Cell 1 (2%)
Infiltration Cellular, Histiocyte 3 (8%) 8 (22%)
Inflammation, Chronic Active 1 (3%) 1 (2%) 1 (3%)
Necrosis, Coagulative 1 (3%)
Pigmentation 5 (13%) 4 (9%) 9 (25%)
Lymph Node, Mesenteric (54) (56) (55)
Angiectasis 24 (44%) 11 (20%) 21 (38%)
Congestion 1 (2%)
Depletion Lymphoid 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 2 (4%)
Hemorrhage 1 (2%) 4 (7%)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 6 (11%) 9 (16%) 4 (7%)
Hyperplasia, Plasma Cell 1 (2%)
Infiltration Cellular, Histiocyte 24 (44%) 22 (39%) 22 (40%)
Inflammation, Chronic Active 7 (13%) 4 (7%)
Pigmentation 23 (43%) 22 (39%) 20 (36%)
Spleen (60) (60) (58)
Angiectasis 1 (2%)
Congestion 1 (2%)
Depletion Lymphoid 1 (2%) 3 (5%) 3 (5%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 6 (10%) 14 (23%) 12 (21%)
Hyperplasia, Lymphoid 2 (3%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (3%)
Necrosis, Coagulative 1 (2%)
Thymus (44) (44) (41)
Cyst 2 (5%) 6 (14%) 12 (29%)
Cyst, Multiple 2 (5%)
Depletion Lymphoid 2 (5%) 8 (18%) 6 (15%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Necrosis, Coagulative 1 (2%) 1 (2%)
Pigmentation 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (57) (58)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 4 (7%) 9 (16%) 13 (22%)
Subcutaneous Tissue, Abscess 1 (2%)
Subcutaneous Tissue, Cyst 1 (2%)
Subcutaneous Tissue, Fibrosis 2 (4%) 1 (2%)
Subcutaneous Tissue, Inflammation, Acute 2 (3%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05061-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 16:49:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATE 1.0% 2.0%
D 71UM 71LM 71HM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (51) (52) (59)
Cartilage, Tarsal, Hyperplasia 1 (2%)
Joint, Tarsal, Hyperostosis 12 (24%) 13 (25%) 12 (20%)
Skeletal Muscle (3) (3) (3)
Fibrosis 1 (33%)
Intercostal, Inflammation, Chronic Active 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60)
Cyst Epithelial Inclusion 1 (2%)
Cerebellum, Necrosis 1 (2%)
Cerebrum, Necrosis 1 (2%)
Thalamus, Mineralization 26 (43%) 20 (33%) 19 (32%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60)
Bronchiectasis 1 (2%)
Congestion 1 (2%) 1 (2%)
Crystals 1 (2%)
Foreign Body 1 (2%)
Granuloma 1 (2%)
Hemorrhage 9 (15%) 9 (15%) 10 (17%)
Infiltration Cellular, Histiocyte 2 (3%) 2 (3%) 6 (10%)
Inflammation, Acute 2 (3%)
Inflammation, Chronic Active 1 (2%) 3 (5%) 1 (2%)
Mineralization 1 (2%)
Pigmentation 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 4 (7%)
Bronchiole, Hyperplasia 1 (2%)
Bronchiole, Metaplasia, Squamous 1 (2%)
Peribronchiolar, Inflammation, Chronic 1 (2%)
Perivascular, Inflammation, Chronic 1 (2%)
Nose (53) (58) (58)
Crystals 1 (2%)
Inflammation, Acute 13 (25%) 11 (19%) 6 (10%)
Glands, Crystals 2 (4%)
Glands, Inflammation, Acute 2 (3%)
Nasolacrimal Duct, Inflammation, Acute 2 (4%)
Respiratory Epithelium, Necrosis 1 (2%)
Trachea (60) (59) (60)
Inflammation, Acute 2 (3%) 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05061-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 16:49:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATE 1.0% 2.0%
D 71UM 71LM 71HM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1)
Anterior, Synechia 1 (100%)
Cornea, Fibrosis 1 (100%)
Cornea, Inflammation, Chronic Active 1 (50%)
Harderian Gland (2) (2) (1)
Inflammation, Chronic Active 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (52) (60)
Autolysis 1 (2%)
Congestion 1 (2%)
Cyst 1 (2%) 1 (2%)
Glomerulosclerosis 3 (6%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Inflammation, Acute, Necrotizing 1 (2%)
Inflammation, Chronic 10 (17%) 1 (2%) 8 (13%)
Inflammation, Chronic Active 47 (78%) 42 (81%) 47 (78%)
Metaplasia, Osseous 1 (2%)
Mineralization 1 (2%)
Necrosis, Coagulative 1 (2%)
Artery, Necrosis, Fibrinoid 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%)
Proximal Convoluted Renal Tubule, Hyperplasia 1 (2%)
Proximal Convoluted Renal Tubule,
Regeneration 2 (3%) 11 (21%) 1 (2%)
Proximal Convoluted Renal Tubule,
Vacuolization Cytoplasmic 1 (2%)
Renal Tubule, Mineralization 1 (2%) 4 (8%) 1 (2%)
Renal Tubule, Pigmentation 42 (81%) 43 (72%)
Renal Tubule, Regeneration 4 (7%) 1 (2%) 4 (7%)
Urinary Bladder (59) (59) (59)
Autolysis 2 (3%) 3 (5%)
Calculus Micro Observation Only 5 (8%) 2 (3%)
Inflammation, Chronic 3 (5%) 7 (12%) 5 (8%)
Inflammation, Chronic Active 37 (63%) 31 (53%) 34 (58%)
Transitional Epithelium, Hyperplasia 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
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