TR 383 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 1-AMINO-2,4-DIBROMOANTHRAQUINONE DATE: 05/19/95
EXPERIMENT: 05061 TEST: 02 TIME: 17:13:40
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES9561903 ROUTE: DOSED FEED NTP C#: 55458
PATHOLOGIST: R. FLEISCHMAN CAS: 81-49-2
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 1-AMINO-2,4-DIBROMOANTHRAQUINONE DATE: 05/19/95
EXPERIMENT: 05061 TEST: 02 TIME: 17:13:40
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES9561903 ROUTE: DOSED FEED NTP C#: 55458
PATHOLOGIST: R. FLEISCHMAN CAS: 81-49-2
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 1-AMINO-2,4-DIBROMOANTHRAQUINONE DATE: 05/19/95
EXPERIMENT: 05061 TEST: 02 TIME: 17:13:40
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES9561903 ROUTE: DOSED FEED NTP C#: 55458
PATHOLOGIST: R. FLEISCHMAN CAS: 81-49-2
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 1-AMINO-2,4-DIBROMOANTHRAQUINONE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatoblastoma
Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Skin Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma
Fibrosarcoma
Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma
Stomach, Forestomach Squamous Cell Carcinoma
Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatoblastoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Stomach, Forestomach Squamous Cell Carcinoma
Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
Uterus Sarcoma Stromal or Polyp Stromal
All Organs Hemangioma
Hemangiosarcoma or Hemangioma
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) 0/60 (0%) | 0/60 (0%) 0/59 (0%) 0/58 (0%) |
|ADJUSTED (b) | 5.0% 4.5% 0.0% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/40 (5%) 1/22 (5%) 0/23 (0%) | 0/39 (0%) 0/34 (0%) 0/32 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.265N P=0.703N P=0.367N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.265N P=0.703N P=0.367N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.265N P=0.703N P=0.367N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.142N | (e) |
|FISHER EXACT | P=0.500N P=0.248N | (e) (e) |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/21 (10%) 0/16 (0%) 0/13 (0%) | 0/0 (0%) 0/0 (0%) 0/1 (0%) |
|ADJUSTED (b) | 9.9% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 1/5 (20%) 0/0 0/1 (0%) | 0/0 0/0 0/0 |
|TERMINAL (d) | 1/12 (8%) 0/5 (0%) 0/6 (0%) | 0/0 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 458 (I) --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.306N P=0.674N P=0.500N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.306N P=0.674N P=0.500N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.145N P=0.272N P=0.393N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.146N | (e) |
|FISHER EXACT | P=0.315N P=0.374N | (e) (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 2/60 (3%) 1/60 (2%) | 1/60 (2%) 2/60 (3%) 2/60 (3%) |
|ADJUSTED (b) | 5.0% 6.7% 4.3% | 2.6% 5.9% 6.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/40 (5%) 0/22 (0%) 1/23 (4%) | 1/39 (3%) 2/34 (6%) 2/33 (6%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 583 729 (T) | 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.566N P=0.514 P=0.689N | P=0.332 P=0.452 P=0.442 |
|INCIDENTAL TUMOR | P=0.389N P=0.571N P=0.689N | P=0.332 P=0.452 P=0.442 |
|LOGISTIC REGRESSION | P=0.468N P=0.637 P=0.689N | P=0.332 P=0.452 P=0.442 |
|COCHRAN-ARMITAGE | P=0.391N | P=0.391 |
|FISHER EXACT | P=0.691N P=0.500N | P=0.500 P=0.500 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 2/60 (3%) 1/60 (2%) | 1/60 (2%) 3/60 (5%) 2/60 (3%) |
|ADJUSTED (b) | 5.0% 6.7% 4.3% | 2.6% 7.5% 6.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/40 (5%) 0/22 (0%) 1/23 (4%) | 1/39 (3%) 2/34 (6%) 2/33 (6%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 583 729 (T) | 729 (T) 372 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.566N P=0.514 P=0.689N | P=0.347 P=0.271 P=0.442 |
|INCIDENTAL TUMOR | P=0.389N P=0.571N P=0.689N | P=0.375 P=0.356 P=0.442 |
|LOGISTIC REGRESSION | P=0.468N P=0.637 P=0.689N | P=0.398 P=0.308 P=0.442 |
|COCHRAN-ARMITAGE | P=0.391N | P=0.400 |
|FISHER EXACT | P=0.691N P=0.500N | P=0.309 P=0.500 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|Intestine Small: Ileum |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/60 (2%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 4.5% 7.1% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/40 (0%) 1/22 (5%) 0/23 (0%) | 0/39 (0%) 0/34 (0%) 0/33 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 665 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.085 P=0.381 P=0.155 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.191 P=0.381 P=0.478 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.106 P=0.381 P=0.198 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.142 | (e) |
|FISHER EXACT | P=0.500 P=0.248 | (e) (e) |
|=================================================================================================================================|
| |
|Intestine Small: Site Unspecified |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/60 (2%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 4.5% 7.1% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/40 (0%) 1/22 (5%) 0/23 (0%) | 0/39 (0%) 0/34 (0%) 0/33 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 665 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.085 P=0.381 P=0.155 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.191 P=0.381 P=0.478 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.106 P=0.381 P=0.198 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.142 | (e) |
|FISHER EXACT | P=0.500 P=0.248 | (e) (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/51 (0%) 0/50 (0%) 0/49 (0%) | 2/49 (4%) 1/50 (2%) 0/48 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 4.7% 2.9% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/1 (0%) 0/0 0/1 (0%) | 0/0 0/0 0/0 |
|TERMINAL (d) | 0/40 (0%) 0/22 (0%) 0/23 (0%) | 1/38 (3%) 1/34 (3%) 0/33 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 610 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.165N P=0.533N P=0.263N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.122N P=0.572N P=0.179N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.144N P=0.492N P=0.247N |
|COCHRAN-ARMITAGE | (e) | P=0.144N |
|FISHER EXACT | (e) (e) | P=0.492N P=0.253N |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 2/60 (3%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 7.5% 6.2% 2.2% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/40 (8%) 1/22 (5%) 0/23 (0%) | 0/39 (0%) 0/34 (0%) 0/33 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 414 484 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.366N P=0.655 P=0.461N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.335N P=0.676N P=0.438N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.227N P=0.535N P=0.335N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.223N | (e) |
|FISHER EXACT | P=0.500N P=0.309N | (e) (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|Liver |
| Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 3/60 (5%) 5/60 (8%) | 0/60 (0%) 0/60 (0%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 8.2% 16.8% | 0.0% 0.0% 6.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/40 (0%) 0/22 (0%) 2/23 (9%) | 0/39 (0%) 0/34 (0%) 2/33 (6%) |
|FIRST INCIDENCE (DAYS) | --- 572 633 | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.011 * P=0.090 P=0.011 * | P=0.082 (e) P=0.202 |
|INCIDENTAL TUMOR | P=0.049 * P=0.542 P=0.069 | P=0.082 (e) P=0.202 |
|LOGISTIC REGRESSION | P=0.018 * P=0.127 P=0.022 * | P=0.082 (e) P=0.202 |
|COCHRAN-ARMITAGE | P=0.023 * | P=0.096 |
|FISHER EXACT | P=0.122 P=0.029 * | (e) P=0.248 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/60 (17%) 40/60 (67%) 43/60 (72%) | 6/60 (10%) 47/60 (78%) 56/60 (93%) |
|ADJUSTED (b) | 24.3% 94.9% 95.4% | 15.4% 95.9% 100.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 2/9 (22%) 4/10 (40%) | 0/10 (0%) 2/10 (20%) 7/10 (70%) |
|TERMINAL (d) | 9/40 (23%) 20/22 (91%) 21/23 (91%) | 6/39 (15%) 32/34 (94%) 33/33 (100%) |
|FIRST INCIDENCE (DAYS) | 723 451 458 (I) | 729 (T) 442 455 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/60 (15%) 19/60 (32%) 21/60 (35%) | 0/60 (0%) 23/60 (38%) 28/60 (47%) |
|ADJUSTED (b) | 20.9% 58.8% 58.4% | 0.0% 57.2% 61.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 1/9 (11%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 7/40 (18%) 10/22 (45%) 9/23 (39%) | 0/39 (0%) 17/34 (50%) 16/33 (48%) |
|FIRST INCIDENCE (DAYS) | 445 458 (I) 535 | --- 503 455 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.006 ** P=0.013 * P=0.022 * | P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P=0.002 ** P=0.007 ** P=0.002 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.009 ** | P<0.001 ** |
|FISHER EXACT | P=0.025 * P=0.010 ** | P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/60 (15%) 21/60 (35%) 24/60 (40%) | 0/60 (0%) 23/60 (38%) 28/60 (47%) |
|ADJUSTED (b) | 20.9% 60.9% 65.3% | 0.0% 57.2% 61.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 1/9 (11%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 7/40 (18%) 10/22 (45%) 11/23 (48%) | 0/39 (0%) 17/34 (50%) 16/33 (48%) |
|FIRST INCIDENCE (DAYS) | 445 458 (I) 535 | --- 503 455 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.001 ** P=0.012 * P=0.004 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P=0.001 ** P=0.003 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.002 ** | P<0.001 ** |
|FISHER EXACT | P=0.010 ** P=0.002 ** | P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/60 (30%) 46/60 (77%) 46/60 (77%) | 6/60 (10%) 48/60 (80%) 58/60 (97%) |
|ADJUSTED (b) | 41.5% 97.8% 97.8% | 15.4% 97.9% 100.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 3/9 (33%) 4/10 (40%) | 0/10 (0%) 2/10 (20%) 8/10 (80%) |
|TERMINAL (d) | 15/40 (38%) 21/22 (95%) 22/23 (96%) | 6/39 (15%) 33/34 (97%) 33/33 (100%) |
|FIRST INCIDENCE (DAYS) | 445 451 458 (I) | 729 (T) 442 455 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/60 (30%) 46/60 (77%) 46/60 (77%) | 6/60 (10%) 48/60 (80%) 58/60 (97%) |
|ADJUSTED (b) | 41.5% 97.8% 97.8% | 15.4% 97.9% 100.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 3/9 (33%) 4/10 (40%) | 0/10 (0%) 2/10 (20%) 8/10 (80%) |
|TERMINAL (d) | 15/40 (38%) 21/22 (95%) 22/23 (96%) | 6/39 (15%) 33/34 (97%) 33/33 (100%) |
|FIRST INCIDENCE (DAYS) | 445 451 458 (I) | 729 (T) 442 455 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/60 (12%) 29/60 (48%) 29/60 (48%) | 4/60 (7%) 20/60 (33%) 15/59 (25%) |
|ADJUSTED (b) | 16.5% 72.5% 69.4% | 9.8% 48.4% 35.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 3/9 (33%) 5/10 (50%) | 0/10 (0%) 3/10 (30%) 2/10 (20%) |
|TERMINAL (d) | 6/40 (15%) 12/22 (55%) 12/23 (52%) | 3/39 (8%) 14/34 (41%) 9/33 (27%) |
|FIRST INCIDENCE (DAYS) | 445 458 (I) 248 | 685 455 (I) 455 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P=0.004 ** P<0.001 ** P=0.003 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** | P=0.010 * P<0.001 ** P=0.008 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P=0.008 ** P<0.001 ** P=0.005 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.009 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** | P<0.001 ** P=0.005 ** |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 4/60 (7%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 2/59 (3%) |
|ADJUSTED (b) | 6.6% 15.9% 3.0% | 0.0% 0.0% 5.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/40 (5%) 2/22 (9%) 0/23 (0%) | 0/39 (0%) 0/34 (0%) 1/33 (3%) |
|FIRST INCIDENCE (DAYS) | 393 673 648 | --- --- 664 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.454N P=0.258 P=0.441N | P=0.085 (e) P=0.211 |
|INCIDENTAL TUMOR | P=0.230N P=0.483 P=0.292N | P=0.094 (e) P=0.252 |
|LOGISTIC REGRESSION | P=0.295N P=0.449 P=0.296N | P=0.092 (e) P=0.229 |
|COCHRAN-ARMITAGE | P=0.253N | P=0.094 |
|FISHER EXACT | P=0.500 P=0.309N | (e) P=0.244 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/60 (17%) 31/60 (52%) 30/60 (50%) | 4/60 (7%) 20/60 (33%) 17/59 (29%) |
|ADJUSTED (b) | 22.7% 76.3% 70.3% | 9.8% 48.4% 39.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 3/9 (33%) 5/10 (50%) | 0/10 (0%) 3/10 (30%) 2/10 (20%) |
|TERMINAL (d) | 8/40 (20%) 13/22 (59%) 12/23 (52%) | 3/39 (8%) 14/34 (41%) 10/33 (30%) |
|FIRST INCIDENCE (DAYS) | 393 458 (I) 248 | 685 455 (I) 455 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P=0.001 ** P<0.001 ** P=0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** | P=0.003 ** P<0.001 ** P=0.003 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P=0.003 ** P<0.001 ** P=0.002 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.003 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** | P<0.001 ** P=0.001 ** |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/52 (0%) 2/54 (4%) 0/56 (0%) | 1/51 (2%) 9/55 (16%) 4/52 (8%) |
|ADJUSTED (b) | 0.0% 6.9% 0.0% | 2.2% 27.2% 12.2% |
|INTERIM SACRIFICE 1 (c)| 0/9 (0%) 0/9 (0%) 0/9 (0%) | 0/8 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/36 (0%) 1/19 (5%) 0/22 (0%) | 0/34 (0%) 7/30 (23%) 3/29 (10%) |
|FIRST INCIDENCE (DAYS) | --- 451 --- | 628 671 553 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.605 P=0.173 (e) | P=0.145 P=0.007 ** P=0.151 |
|INCIDENTAL TUMOR | P=0.651N P=0.251 (e) | P=0.207 P=0.009 ** P=0.246 |
|LOGISTIC REGRESSION | P=0.634N P=0.268 (e) | P=0.167 P=0.008 ** P=0.179 |
|COCHRAN-ARMITAGE | P=0.653N | P=0.202 |
|FISHER EXACT | P=0.257 (e) | P=0.011 * P=0.187 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|Skin |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 3/60 (5%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 5.0% 11.9% 3.8% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/40 (5%) 1/22 (5%) 0/23 (0%) | 0/39 (0%) 0/34 (0%) 0/33 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 706 722 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.578 P=0.262 P=0.679N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.346N P=0.497 P=0.518N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.551N P=0.323 P=0.650N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.400N | (e) |
|FISHER EXACT | P=0.500 P=0.500N | (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/60 (10%) 10/60 (17%) 3/60 (5%) | 2/60 (3%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 14.1% 29.5% 8.7% | 4.3% 2.9% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/40 (10%) 3/22 (14%) 0/23 (0%) | 0/39 (0%) 0/34 (0%) 0/33 (0%) |
|FIRST INCIDENCE (DAYS) | 621 501 606 | 478 727 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.494N P=0.053 P=0.476N | P=0.162N P=0.526N P=0.254N |
|INCIDENTAL TUMOR | P=0.066N P=0.587 P=0.046N* | P=0.072N P=0.264N P=0.140N |
|LOGISTIC REGRESSION | P=0.068N P=0.532 P=0.065N | P=0.142N P=0.497N P=0.247N |
|COCHRAN-ARMITAGE | P=0.229N | P=0.142N |
|FISHER EXACT | P=0.211 P=0.245N | P=0.500N P=0.248N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 8/60 (13%) 2/60 (3%) | 2/60 (3%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 6.9% 22.8% 5.1% | 4.3% 2.9% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/40 (3%) 2/22 (9%) 0/23 (0%) | 0/39 (0%) 0/34 (0%) 0/33 (0%) |
|FIRST INCIDENCE (DAYS) | 621 501 606 | 478 727 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.526 P=0.037 * P=0.638N | P=0.162N P=0.526N P=0.254N |
|INCIDENTAL TUMOR | P=0.123N P=0.567 P=0.066N | P=0.072N P=0.264N P=0.140N |
|LOGISTIC REGRESSION | P=0.092N P=0.521 P=0.530N | P=0.142N P=0.497N P=0.247N |
|COCHRAN-ARMITAGE | P=0.430N | P=0.142N |
|FISHER EXACT | P=0.102 P=0.500N | P=0.500N P=0.248N |
|=================================================================================================================================|
| |
|Skin |
| Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 8/60 (13%) 2/60 (3%) | 2/60 (3%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 9.3% 22.8% 5.1% | 4.3% 2.9% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/40 (5%) 2/22 (9%) 0/23 (0%) | 0/39 (0%) 0/34 (0%) 0/33 (0%) |
|FIRST INCIDENCE (DAYS) | 621 501 606 | 478 727 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.501N P=0.066 P=0.508N | P=0.162N P=0.526N P=0.254N |
|INCIDENTAL TUMOR | P=0.077N P=0.630N P=0.046N* | P=0.072N P=0.264N P=0.140N |
|LOGISTIC REGRESSION | P=0.054N P=0.635 P=0.381N | P=0.142N P=0.497N P=0.247N |
|COCHRAN-ARMITAGE | P=0.305N | P=0.142N |
|FISHER EXACT | P=0.181 P=0.340N | P=0.500N P=0.248N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|Spleen |
| Mast Cell Tumor Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 0/58 (0%) | 0/60 (0%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 0.0% 7.8% 0.0% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/40 (0%) 1/22 (5%) 0/23 (0%) | 0/39 (0%) 0/34 (0%) 0/33 (0%) |
|FIRST INCIDENCE (DAYS) | --- 673 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.555 P=0.137 (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.648N P=0.256 (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.617 P=0.185 (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.662 | (e) |
|FISHER EXACT | P=0.248 (e) | (e) (e) |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 12/60 (20%) 14/60 (23%) | 0/60 (0%) 12/60 (20%) 11/60 (18%) |
|ADJUSTED (b) | 0.0% 36.5% 38.8% | 0.0% 30.9% 27.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/40 (0%) 4/22 (18%) 4/23 (17%) | 0/39 (0%) 8/34 (24%) 5/33 (15%) |
|FIRST INCIDENCE (DAYS) | --- 505 458 (I) | --- 587 501 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P=0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.003 ** P=0.001 ** | P=0.003 ** P<0.001 ** P=0.002 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P=0.002 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.002 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 19/60 (32%) 28/60 (47%) | 2/60 (3%) 29/60 (48%) 36/60 (60%) |
|ADJUSTED (b) | 0.0% 61.2% 74.4% | 5.1% 63.4% 81.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 1/10 (10%) | 0/10 (0%) 4/10 (40%) 2/10 (20%) |
|TERMINAL (d) | 0/40 (0%) 11/22 (50%) 14/23 (61%) | 2/39 (5%) 18/34 (53%) 25/33 (76%) |
|FIRST INCIDENCE (DAYS) | --- 505 458 (I) | 729 (T) 455 (I) 455 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 13/60 (22%) 16/60 (27%) | 2/60 (3%) 20/60 (33%) 29/60 (48%) |
|ADJUSTED (b) | 0.0% 51.0% 55.6% | 5.1% 45.8% 73.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 4/10 (40%) 2/10 (20%) |
|TERMINAL (d) | 0/40 (0%) 10/22 (45%) 11/23 (48%) | 2/39 (5%) 12/34 (35%) 23/33 (70%) |
|FIRST INCIDENCE (DAYS) | --- 613 606 | 729 (T) 455 (I) 455 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/59 (0%) 0/59 (0%) 0/59 (0%) | 3/60 (5%) 1/60 (2%) 2/58 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 7.7% 2.9% 6.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/39 (0%) 0/22 (0%) 0/23 (0%) | 3/39 (8%) 1/34 (3%) 2/33 (6%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.467N P=0.355N P=0.576N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.467N P=0.355N P=0.576N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.467N P=0.355N P=0.576N |
|COCHRAN-ARMITAGE | (e) | P=0.413N |
|FISHER EXACT | (e) (e) | P=0.309N P=0.516N |
|=================================================================================================================================|
| |
|Uterus |
| Leiomyoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 2/60 (3%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | | 5.1% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 2/39 (5%) 0/34 (0%) 0/33 (0%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.115N P=0.269N P=0.276N |
|INCIDENTAL TUMOR | | P=0.115N P=0.269N P=0.276N |
|LOGISTIC REGRESSION | | P=0.115N P=0.269N P=0.276N |
|COCHRAN-ARMITAGE | | P=0.096N |
|FISHER EXACT | | P=0.248N P=0.248N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 0/60 (0%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | | 0.0% 4.6% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 0/39 (0%) 0/34 (0%) 0/33 (0%) |
|FIRST INCIDENCE (DAYS) | | --- 587 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.647 P=0.225 (e) |
|INCIDENTAL TUMOR | | P=0.529N P=0.245 (e) |
|LOGISTIC REGRESSION | | P=0.668 P=0.240 (e) |
|COCHRAN-ARMITAGE | | P=0.668 |
|FISHER EXACT | | P=0.248 (e) |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 0/60 (0%) 3/60 (5%) 0/60 (0%) |
|ADJUSTED (b) | | 0.0% 8.1% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 0/39 (0%) 2/34 (6%) 0/33 (0%) |
|FIRST INCIDENCE (DAYS) | | --- 671 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.597 P=0.105 (e) |
|INCIDENTAL TUMOR | | P=0.633 P=0.134 (e) |
|LOGISTIC REGRESSION | | P=0.625 P=0.113 (e) |
|COCHRAN-ARMITAGE | | P=0.639 |
|FISHER EXACT | | P=0.122 (e) |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 0/60 (0%) 5/60 (8%) 0/60 (0%) |
|ADJUSTED (b) | | 0.0% 12.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 0/39 (0%) 2/34 (6%) 0/33 (0%) |
|FIRST INCIDENCE (DAYS) | | --- 587 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.562 P=0.029 * (e) |
|INCIDENTAL TUMOR | | P=0.525N P=0.038 * (e) |
|LOGISTIC REGRESSION | | P=0.605 P=0.032 * (e) |
|COCHRAN-ARMITAGE | | P=0.609 |
|FISHER EXACT | | P=0.029 * (e) |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) | 4/60 (7%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 9.6% 0.0% 3.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/40 (0%) 0/22 (0%) 0/23 (0%) | 3/39 (8%) 0/34 (0%) 1/33 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 478 --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.105N P=0.080N P=0.222N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.083N P=0.042N* P=0.178N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.084N P=0.064N P=0.183N |
|COCHRAN-ARMITAGE | (e) | P=0.082N |
|FISHER EXACT | (e) (e) | P=0.059N P=0.182N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 2/60 (3%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 7.5% 6.2% 4.4% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/40 (8%) 1/22 (5%) 0/23 (0%) | 0/39 (0%) 0/34 (0%) 0/33 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 414 484 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.560N P=0.655 P=0.650N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.519N P=0.676N P=0.610N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.395N P=0.535N P=0.506N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.407N | (e) |
|FISHER EXACT | P=0.500N P=0.500N | (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 2/60 (3%) 2/60 (3%) | 4/60 (7%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 7.5% 6.2% 4.4% | 9.6% 0.0% 3.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/40 (8%) 1/22 (5%) 0/23 (0%) | 3/39 (8%) 0/34 (0%) 1/33 (3%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 414 484 | 478 --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.560N P=0.655 P=0.650N | P=0.105N P=0.080N P=0.222N |
|INCIDENTAL TUMOR | P=0.519N P=0.676N P=0.610N | P=0.083N P=0.042N* P=0.178N |
|LOGISTIC REGRESSION | P=0.395N P=0.535N P=0.506N | P=0.084N P=0.064N P=0.183N |
|COCHRAN-ARMITAGE | P=0.407N | P=0.082N |
|FISHER EXACT | P=0.500N P=0.500N | P=0.059N P=0.182N |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 10/60 (17%) 7/60 (12%) 8/60 (13%) | 11/60 (18%) 15/60 (25%) 13/60 (22%) |
|ADJUSTED (b) | 21.9% 23.2% 25.8% | 25.5% 36.6% 35.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/40 (13%) 2/22 (9%) 4/23 (17%) | 7/39 (18%) 10/34 (29%) 10/33 (30%) |
|FIRST INCIDENCE (DAYS) | 480 612 512 | 653 202 680 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.397 P=0.524 P=0.447 | P=0.237 P=0.181 P=0.268 |
|INCIDENTAL TUMOR | P=0.222N P=0.081N P=0.262N | P=0.275 P=0.330 P=0.365 |
|LOGISTIC REGRESSION | P=0.229N P=0.119N P=0.211N | P=0.277 P=0.230 P=0.313 |
|COCHRAN-ARMITAGE | P=0.346N | P=0.370 |
|FISHER EXACT | P=0.301N P=0.399N | P=0.253 P=0.410 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated |
| Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 10/60 (17%) 6/60 (10%) 7/60 (12%) | 11/60 (18%) 15/60 (25%) 13/60 (22%) |
|ADJUSTED (b) | 21.9% 20.8% 23.3% | 25.5% 36.6% 35.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/9 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/40 (13%) 2/22 (9%) 4/23 (17%) | 7/39 (18%) 10/34 (29%) 10/33 (30%) |
|FIRST INCIDENCE (DAYS) | 480 612 512 | 653 202 680 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.517 P=0.565N P=0.567 | P=0.237 P=0.181 P=0.268 |
|INCIDENTAL TUMOR | P=0.183N P=0.073N P=0.211N | P=0.275 P=0.330 P=0.365 |
|LOGISTIC REGRESSION | P=0.183N P=0.294N P=0.157N | P=0.277 P=0.230 P=0.313 |
|COCHRAN-ARMITAGE | P=0.247N | P=0.370 |
|FISHER EXACT | P=0.211N P=0.301N | P=0.253 P=0.410 |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 20/60 (33%) 47/60 (78%) 50/60 (83%) | 24/60 (40%) 51/60 (85%) 58/60 (97%) |
|ADJUSTED (b) | 47.2% 100.0% 100.0% | 54.1% 96.2% 100.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 4/9 (44%) 7/10 (70%) | 0/10 (0%) 5/10 (50%) 8/10 (80%) |
|TERMINAL (d) | 18/40 (45%) 22/22 (100%) 23/23 (100%) | 19/39 (49%) 32/34 (94%) 33/33 (100%) |
|FIRST INCIDENCE (DAYS) | 445 451 248 | 478 442 455 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 26/60 (43%) 40/60 (67%) 40/60 (67%) | 14/60 (23%) 40/60 (67%) 38/60 (63%) |
|ADJUSTED (b) | 51.5% 83.1% 88.5% | 30.9% 84.8% 78.9% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 1/9 (11%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 16/40 (40%) 14/22 (64%) 18/23 (78%) | 8/39 (21%) 27/34 (79%) 23/33 (70%) |
|FIRST INCIDENCE (DAYS) | 393 414 458 (I) | 478 202 455 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.011 * P=0.171 P=0.016 * | P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P=0.019 * P=0.067 P=0.030 * | P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.006 ** | P<0.001 ** |
|FISHER EXACT | P=0.008 ** P=0.008 ** | P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 05/19/95 EXPERIMENT: 05061 TEST: 02 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1-AMINO-2,4-DIBROMOANTHRAQUINONE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATE 1.0% 2.0% | UNTREATE 1.0% 2.0% |
| | D 71UM 71LM 71HM | D 71UF 71LF 71HF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 38/60 (63%) 53/60 (88%) 55/60 (92%) | 32/60 (53%) 55/60 (92%) 59/60 (98%) |
|ADJUSTED (b) | 75.8% 100.0% 100.0% | 66.7% 100.0% 100.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 4/9 (44%) 8/10 (80%) | 0/10 (0%) 5/10 (50%) 9/10 (90%) |
|TERMINAL (d) | 28/40 (70%) 22/22 (100%) 23/23 (100%) | 23/39 (59%) 34/34 (100%) 33/33 (100%) |
|FIRST INCIDENCE (DAYS) | 393 414 248 | 478 202 455 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.004 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 458
Female interim sacrifices(days): 455
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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