TR 383 Mouse Pathology Tables
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
Facility: TSI Mason Research
Chemical CAS #: 81-49-2
Lock Date: 03/25/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 4| 6| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7|
DAY ON TEST | 5| 5| 3| 3| 8| 5| 3| 3| 3| 9| 3| 3| 5| 1| 7| 3| 3| 3| 0| 5| 3| 5| 5| 3| 3|
| 7| 5| 4| 2| 5| 5| 3| 3| 4| 2| 3| 3| 5| 0| 8| 3| 3| 3| 1| 5| 3| 5| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 3 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 |
Peyer's Patch, Epithelium, | |
Proliferation | 2|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 1 3 |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Autolysis | 4 |
Peyer's Patch, Hyperplasia | 1|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 |
Fatty Change | 1 2 |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Necrosis, Coagulative | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic Active | 3 |
Mineralization | |
Necrosis, Coagulative | 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
Inflammation, Chronic | 1 1 1 1 |
Inflammation, Chronic Active | 2 1 1 1 1 1 2 1 1|
Vacuolization Cytoplasmic | 1 2 2 1 2 2 1 1|
Duct, Dilatation | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +|
Sublingual Gland, Inflammation, | |
Chronic | |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 4| 6| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7|
DAY ON TEST | 5| 5| 3| 3| 8| 5| 3| 3| 3| 9| 3| 3| 5| 1| 7| 3| 3| 3| 0| 5| 3| 5| 5| 3| 3|
| 7| 5| 4| 2| 5| 5| 3| 3| 4| 2| 3| 3| 5| 0| 8| 3| 3| 3| 1| 5| 3| 5| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acanthosis | 1 2 2 2 |
Hyperkeratosis | 1 2 2 1 1 |
Inflammation, Chronic Active | 2 1 |
Ulcer | |
Ulcer, Multiple | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 2|
Mineralization | |
__________________________________________________________________________|
Tooth | |
Abscess | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 |
Inflammation, Chronic | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Hematopoietic Cell Proliferation | 1 |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + M + M + + + M M + + + M + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + M + + M + + M M + + + + + + + + + + + + + M + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 2 |
Pars Distalis, Pigmentation | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 4| 6| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7|
DAY ON TEST | 5| 5| 3| 3| 8| 5| 3| 3| 3| 9| 3| 3| 5| 1| 7| 3| 3| 3| 0| 5| 3| 5| 5| 3| 3|
| 7| 5| 4| 2| 5| 5| 3| 3| 4| 2| 3| 3| 5| 0| 8| 3| 3| 3| 1| 5| 3| 5| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 2 2 3 4|
Cyst, Multiple | 2 |
Inflammation, Acute, Necrotizing | |
Pigmentation | |
Periovarian Tissue, Cyst | 4 |
Periovarian Tissue, Inflammation, | |
Chronic | 1 1 |
Periovarian Tissue, Inflammation, | |
Chronic Active | 1 1 1 1 1 1 1 2 1|
Periovarian Tissue, Mineralization | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 3 3 4 3 2 4 2 2 2 2 2 |
Inflammation, Chronic Active | |
Endometrium, Hyperplasia | 2 2 3 1 2 2 2 2 2 2 1 2 2 2 1 3 3 2 1 3|
Epithelium, Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 1 |
Myeloid Cell, Sternal, Hyperplasia | 3 |
Sternal, Myelofibrosis | 1 2 1 2 2 1 2 1 2 2 1 2|
__________________________________________________________________________|
Lymph Node | + + + + + |
Lumbar, Hyperplasia, Lymphoid | 2 |
Lumbar, Inflammation, Acute | 2 |
Mediastinal, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + M + M + + M M + + + M + + M + M + +|
Congestion | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + M + +|
Angiectasis | 2 1 |
Depletion Lymphoid | 3 2 |
Hyperplasia, Lymphoid | 4 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | |
Necrosis, Coagulative | 2 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 4| 6| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7|
DAY ON TEST | 5| 5| 3| 3| 8| 5| 3| 3| 3| 9| 3| 3| 5| 1| 7| 3| 3| 3| 0| 5| 3| 5| 5| 3| 3|
| 7| 5| 4| 2| 5| 5| 3| 3| 4| 2| 3| 3| 5| 0| 8| 3| 3| 3| 1| 5| 3| 5| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 2 4 |
Hyperplasia, Lymphoid | 2 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Thymus | + + + + I + + + + + + + + M + + + + + + + + + + +|
Angiectasis | |
Cyst | 1 1 1 1 1 1 1 1 1 1 1|
Depletion Lymphoid | 3 3 2 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + M M M + + + + + + + M + M + + + +|
Hyperplasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2|
Inflammation, Acute | 3|
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 1 |
Subcutaneous Tissue, Mineralization | 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | M M + + + M + + + + + + M + + + + + + M + M M + +|
__________________________________________________________________________|
Skeletal Muscle | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 1 1 |
Inflammation, Chronic Active | 2 |
Leukocytosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + M + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 1 1 1 1|
Glands, Inflammation, Acute | 1 |
Nasolacrimal Duct, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 4| 4| 7| 7| 6| 4| 7| 7| 7| 5| 7| 7| 4| 6| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7|
DAY ON TEST | 5| 5| 3| 3| 8| 5| 3| 3| 3| 9| 3| 3| 5| 1| 7| 3| 3| 3| 0| 5| 3| 5| 5| 3| 3|
| 7| 5| 4| 2| 5| 5| 3| 3| 4| 2| 3| 3| 5| 0| 8| 3| 3| 3| 1| 5| 3| 5| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | |
Hydronephrosis | 1 |
Infarct | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2|
Proximal Convoluted Renal Tubule, | |
Degeneration, Hyaline | |
Renal Tubule, Casts Protein | |
Renal Tubule, Regeneration | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 3 |
Inflammation, Chronic | 1 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 2 1 1|
Submucosa, Proliferation | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 3| 0| 5| 2|
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 6| 3| 5| 3| 4| 4| 3| 4| 8| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Peyer's Patch, Epithelium, | |
Proliferation | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + A + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Autolysis | 3 |
Peyer's Patch, Hyperplasia | 2 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Fatty Change | |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
Necrosis, Coagulative | 1 1 2 1 1 1 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | |
Mineralization | |
Necrosis, Coagulative | |
Pigmentation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 1 1 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 1 1 2 2 1 1|
Vacuolization Cytoplasmic | 1 1 1 1 1 1 2 2 1 1 |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sublingual Gland, Inflammation, | |
Chronic | |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 1 2 1 1 1 1 1 2 2 1 1 1 1 1 2 1 2|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 3| 0| 5| 2|
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 6| 3| 5| 3| 4| 4| 3| 4| 8| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acanthosis | 2 1 1|
Hyperkeratosis | 1 1 2 1|
Inflammation, Chronic Active | 1 2 1|
Ulcer | 2 |
Ulcer, Multiple | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Autolysis | 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 |
Mineralization | |
__________________________________________________________________________|
Tooth | +|
Abscess | 2|
Dysplasia | 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation, Chronic | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Parathyroid Gland | M + + + M M M + + + + M + + M M + + M + + M + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + M + + + + + M M + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 1 1 1 |
Pars Distalis, Hyperplasia | 2 1 1 |
Pars Distalis, Pigmentation | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 3| 0| 5| 2|
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 6| 3| 5| 3| 4| 4| 3| 4| 8| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + M + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Cyst | 1 2 2 3 1 2|
Cyst, Multiple | |
Inflammation, Acute, Necrotizing | 2 |
Pigmentation | 3 |
Periovarian Tissue, Cyst | |
Periovarian Tissue, Inflammation, | |
Chronic | |
Periovarian Tissue, Inflammation, | |
Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 |
Periovarian Tissue, Mineralization | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hydrometra | 2 2 4 2 4 2 2 4 |
Inflammation, Chronic Active | 2 |
Endometrium, Hyperplasia | 2 2 2 2 2 2 2 1 1 3 2 1 2 2 3 1 |
Epithelium, Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
Myeloid Cell, Sternal, Hyperplasia | |
Sternal, Myelofibrosis | 2 2 3 2 2 2 3 1 3 2 2 2 2 2 2 1 3 1 1|
__________________________________________________________________________|
Lymph Node | + |
Lumbar, Hyperplasia, Lymphoid | |
Lumbar, Inflammation, Acute | |
Mediastinal, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + + M M + + + + I + + M + M M + + + M M + +|
Congestion | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + M + + + + + + + +|
Angiectasis | 1 2 1 |
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | |
Necrosis, Coagulative | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Depletion Lymphoid | 3 2 3 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 3| 0| 5| 2|
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 6| 3| 5| 3| 4| 4| 3| 4| 8| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 1 1 2 2 2 2 1 2 2 1 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + M + M + + + M + + + M|
Angiectasis | 2 |
Cyst | 1 1 1 1 1 1 1 1 |
Depletion Lymphoid | 4 |
Hyperplasia, Lymphoid | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M M + + M M M M + M M M + + + M + M M M + +|
Hyperplasia | 1 2|
Inflammation, Chronic | 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Acute | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
Subcutaneous Tissue, Mineralization | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + M + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
Inflammation, Chronic Active | 1 |
Leukocytosis | |
__________________________________________________________________________|
Nose | + + + + M + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 1 1 1 1 1 1 1 1 1 1 |
Glands, Inflammation, Acute | 1 |
Nasolacrimal Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 3| 0| 5| 2|
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 6| 3| 5| 3| 4| 4| 3| 4| 8| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
UNTREATE | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | 4 |
Hydronephrosis | |
Infarct | 2 |
Inflammation, Chronic | 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1|
Proximal Convoluted Renal Tubule, | |
Degeneration, Hyaline | 2 |
Renal Tubule, Casts Protein | 1 |
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Submucosa, Proliferation | 2 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 3| 3| 5| 3| 3| 3| 0| 0| | |
| 3| 5| 3| 3| 7| 4| 4| 4| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M + | 59 |
Autolysis | | 3 3.3|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 1 | 6 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Autolysis | | 3 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Autolysis | | 2 2.0|
Peyer's Patch, Epithelium, | | |
Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Autolysis | | 4 2.8|
Peyer's Patch, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + M + + + | 58 |
Autolysis | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 57 |
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
Autolysis | | 2 3.5|
Peyer's Patch, Hyperplasia | 2 | 4 1.8|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Autolysis | | 2 1.5|
Fatty Change | 1 | 3 1.3|
Hematopoietic Cell Proliferation | 3 2 | 3 2.3|
Inflammation, Chronic Active | 1 1 1 1 1 1 | 36 1.0|
Necrosis, Coagulative | 1 1 1 | 16 1.1|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Inflammation, Chronic Active | 1 4 | 3 2.7|
Mineralization | 1 | 1 1.0|
Necrosis, Coagulative | | 1 3.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Cytoplasmic Alteration | | 3 1.0|
Inflammation, Chronic | 1 | 5 1.0|
Inflammation, Chronic Active | 1 1 1 1 2 1 | 25 1.2|
Vacuolization Cytoplasmic | 1 2 | 20 1.4|
Duct, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 3| 3| 5| 3| 3| 3| 0| 0| | |
| 3| 5| 3| 3| 7| 4| 4| 4| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Sublingual Gland, Inflammation, | | |
Chronic | 1 | 1 1.0|
Submandibular Gland, Inflammation, | | |
Chronic | 1 1 1 1 1 1 1 2 | 47 1.1|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Acanthosis | 2 2 | 9 1.7|
Hyperkeratosis | 2 | 10 1.4|
Inflammation, Chronic Active | 1 2 | 7 1.4|
Ulcer | 2 | 2 2.0|
Ulcer, Multiple | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Autolysis | | 2 2.0|
Inflammation, Chronic | 1 | 2 1.0|
Inflammation, Chronic Active | 1 1 1 2 1 | 21 1.1|
Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Abscess | | 1 2.0|
Dysplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | | 2 1.0|
Inflammation, Chronic | | 9 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Angiectasis | | 2 1.5|
Hematopoietic Cell Proliferation | | 1 1.0|
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 49 |
Hyperplasia | 1 | 3 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + + + + + | 43 |
Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 51 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | | 3 1.0|
Pars Distalis, Hyperplasia | 2 2 3 | 8 1.8|
Pars Distalis, Pigmentation | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 3| 3| 5| 3| 3| 3| 0| 0| | |
| 3| 5| 3| 3| 7| 4| 4| 4| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 2.0|
C-Cell, Hyperplasia | | 1 1.0|
Follicle, Cyst | 2 | 2 2.0|
Follicular Cell, Hyperplasia | | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Angiectasis | | 2 2.0|
Cyst | 3 2 4 | 13 2.4|
Cyst, Multiple | | 1 2.0|
Inflammation, Acute, Necrotizing | | 1 2.0|
Pigmentation | | 1 3.0|
Periovarian Tissue, Cyst | | 1 4.0|
Periovarian Tissue, Inflammation, | | |
Chronic | | 2 1.0|
Periovarian Tissue, Inflammation, | | |
Chronic Active | 3 1 1 3 1 | 29 1.2|
Periovarian Tissue, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Hydrometra | 2 1 | 22 2.5|
Inflammation, Chronic Active | 2 2 2 | 4 2.0|
Endometrium, Hyperplasia | 3 2 2 2 2 3 2 2 | 44 2.0|
Epithelium, Metaplasia, Squamous | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myelofibrosis | | 2 1.0|
Myeloid Cell, Sternal, Hyperplasia | 4 | 2 3.5|
Sternal, Myelofibrosis | 3 3 2 3 2 2 1 | 38 1.9|
__________________________________________________________________________|____________|
Lymph Node | + | 7 |
Lumbar, Hyperplasia, Lymphoid | | 1 2.0|
Lumbar, Inflammation, Acute | | 1 2.0|
Mediastinal, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + M + M + + + + | 38 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 3| 3| 5| 3| 3| 3| 0| 0| | |
| 3| 5| 3| 3| 7| 4| 4| 4| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Congestion | 1 | 1 1.0|
Hyperplasia, Lymphoid | 3 3 | 3 2.7|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Pigmentation | 1 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 56 |
Angiectasis | 1 2 | 7 1.4|
Depletion Lymphoid | | 2 2.5|
Hyperplasia, Lymphoid | 4 | 2 4.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 | 36 1.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Necrosis, Coagulative | | 1 2.0|
Pigmentation | 1 1 1 1 1 1 1 1 | 34 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Autolysis | | 1 2.0|
Depletion Lymphoid | 3 | 4 2.8|
Fibrosis | | 1 1.0|
Hematopoietic Cell Proliferation | 2 4 | 6 2.8|
Hyperplasia, Lymphoid | 2 1 3 | 15 1.8|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + M M M | 49 |
Angiectasis | | 1 2.0|
Cyst | 1 | 21 1.0|
Depletion Lymphoid | | 4 3.0|
Hyperplasia, Lymphoid | | 3 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M M + M M + M + | 35 |
Hyperplasia | | 2 1.5|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 1 2.0|
Inflammation, Acute | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 1.0|
Subcutaneous Tissue, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + M + + M + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 3| 3| 5| 3| 3| 3| 0| 0| | |
| 3| 5| 3| 3| 7| 4| 4| 4| 6| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATE | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Thalamus, Mineralization | 1 1 1 1 1 | 24 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Hemorrhage | 1 | 4 1.0|
Inflammation, Chronic Active | 1 | 3 1.3|
Leukocytosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 58 |
Inflammation, Acute | 1 1 1 | 21 1.0|
Glands, Inflammation, Acute | | 2 1.0|
Nasolacrimal Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Glomerulosclerosis | 2 | 2 3.0|
Hydronephrosis | | 1 1.0|
Infarct | | 1 2.0|
Inflammation, Chronic | 1 1 1 2 1 1 1 1 1 1 | 53 1.1|
Proximal Convoluted Renal Tubule, | | |
Degeneration, Hyaline | | 1 2.0|
Renal Tubule, Casts Protein | | 1 1.0|
Renal Tubule, Regeneration | | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Autolysis | | 3 3.0|
Inflammation, Chronic | 1 1 | 7 1.0|
Inflammation, Chronic Active | 2 1 1 1 1 1 1 1 | 42 1.1|
Submucosa, Proliferation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 1| 3| 3| 3| 3| 5| 3| 3| 5| 1| 1|
| 0| 0| 0| 7| 2| 0| 0| 0| 0| 2| 0| 0| 0| 5| 3| 0| 0| 0| 0| 7| 0| 0| 5| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + M + + + + + + + + +|
Autolysis | 3 2 |
Inflammation, Chronic Active | 1 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 |
Inflammation, Acute | |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + + +|
Autolysis | 3 |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1|
Autolysis | 2 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 4 |
Inflammation, Acute | |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 |
Clear Cell Focus | 1 1 1|
Eosinophilic Focus | 2 1 |
Fatty Change | 1 |
Hematopoietic Cell Proliferation | 2 1 |
Inflammation, Acute | 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | 1 |
Necrosis, Coagulative | 1 1 1 2 1 1 1 2 1 1 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Bile Duct, Hyperplasia, Focal | |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + |
Fibrosis | 1 |
Inflammation, Chronic Active | 2 3 |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cytoplasmic Alteration | |
Inflammation, Chronic Active | 1 1 1 2 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 1| 3| 3| 3| 3| 5| 3| 3| 5| 1| 1|
| 0| 0| 0| 7| 2| 0| 0| 0| 0| 2| 0| 0| 0| 5| 3| 0| 0| 0| 0| 7| 0| 0| 5| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation | 1 |
Vacuolization Cytoplasmic | 1 1 1 1 1 1 3 1 |
Duct, Dilatation | 2 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Sublingual Gland, Inflammation, | |
Chronic | |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 1 2 1 1 2 |
Erosion | |
Hyperkeratosis | 2 2 2 1 1 2 |
Hyperplasia, Basal Cell | 2 1 1 |
Inflammation, Chronic Active | 2 1 1 1 1 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 |
Mineralization | 1 |
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 1 |
Inflammation, Chronic Active | |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + M + M + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + I + + M + + + + + + + + + + + I + + + + + + +|
Pars Distalis, Hyperplasia | 1 2 1 1 1 2 1 1 1 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 1| 3| 3| 3| 3| 5| 3| 3| 5| 1| 1|
| 0| 0| 0| 7| 2| 0| 0| 0| 0| 2| 0| 0| 0| 5| 3| 0| 0| 0| 0| 7| 0| 0| 5| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | 1 2 2 1 1 2 2 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + M + +|
Abscess | 3 4 |
Angiectasis | 2 2 |
Cyst | 2 1 4 1 4 2 |
Cyst, Multiple | 2 2 |
Hemorrhage | |
Mineralization | |
Periovarian Tissue, Cyst | 1 |
Periovarian Tissue, Inflammation, | |
Chronic Active | 1 1 1 3 2 1 1 1 1 1 1|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hydrometra | 3 |
Inflammation, Acute | |
Inflammation, Chronic Active | 1 2 |
Endometrium, Hyperplasia | 2 2 2 2 2 1 1 1 2 2 2 2 1 1 2 2|
Epithelium, Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 1 |
Myeloid Cell, Sternal, Hyperplasia | |
Sternal, Myelofibrosis | 2 3 2 2 2 3 2 2 2 1 1 2 2 2 2 1|
__________________________________________________________________________|
Lymph Node | + + + + |
Pancreatic, Hyperplasia, Lymphoid | 1 |
Renal, Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + M + + + + I + + + + + + + +|
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
Pigmentation | 2 |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + M + + + + + + + + + + + +|
Angiectasis | 1 |
Depletion Lymphoid | |
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 1| 3| 3| 3| 3| 5| 3| 3| 5| 1| 1|
| 0| 0| 0| 7| 2| 0| 0| 0| 0| 2| 0| 0| 0| 5| 3| 0| 0| 0| 0| 7| 0| 0| 5| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 3 1|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | |
Mineralization | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 3 1 3 3 1 |
Hyperplasia, Lymphoid | 1 1 2 1 2 1|
__________________________________________________________________________|
Thymus | + + + M + + + + + M + + + + M + M M + + + + + + +|
Cyst | 1 1 1 1 1 1 1 1 1 1|
Depletion Lymphoid | |
Hemorrhage | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + M M M M + M + + M M M M + M + + + +|
Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Cyst Epithelial | |
Inclusion | |
Subcutaneous Tissue, Fibrosis | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + M + + + + + M + + M + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perivascular, Inflammation, Chronic | |
Thalamus, Mineralization | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 |
Inflammation, Chronic Active | |
Leukocytosis | |
Pleura, Inflammation, Acute | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + M + + + + + +|
Inflammation, Acute | 1 1 |
Nasolacrimal Duct, Inflammation, | |
Acute | 1 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 7| 3| 3| 3| 3| 5| 3| 3| 3| 5| 1| 3| 3| 3| 3| 5| 3| 3| 5| 1| 1|
| 0| 0| 0| 7| 2| 0| 0| 0| 0| 2| 0| 0| 0| 5| 3| 0| 0| 0| 0| 7| 0| 0| 5| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + M + + + + + M + + M + +|
Glomerulosclerosis | 1 |
Hydronephrosis | |
Inflammation, Chronic | 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1|
Metaplasia, Osseous | 1 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Atrophy | 1 |
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1|
Renal Tubule, Regeneration | 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 2| 7| 7| 6| 6| 4| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 5| 5| 5| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 7| 7| 4| 3| 5| 3| 3| 3|
| 0| 0| 0| 7| 5| 7| 7| 0| 0| 7| 0| 0| 6| 3| 2| 3| 0| 9| 1| 2| 3| 5| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + M + + + + + + + + + + + + M +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + M + + M + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 1 1 1 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Acute | 2 |
Peyer's Patch, Hyperplasia | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Peyer's Patch, Hyperplasia | 1 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Autolysis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Acute | 1 |
Peyer's Patch, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 |
Clear Cell Focus | 1 1 1 3 |
Eosinophilic Focus | 1 2 |
Fatty Change | 1 1 |
Hematopoietic Cell Proliferation | 2 1 3|
Inflammation, Acute | 1 1 |
Inflammation, Chronic Active | 2 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | 4 |
Necrosis, Coagulative | 2 2 1 1 1 1 3 1 1 2 1 1 3|
Pigmentation | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Bile Duct, Hyperplasia, Focal | |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + + +|
Fibrosis | 2 1 |
Inflammation, Chronic Active | 2 3|
Necrosis, Coagulative | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cytoplasmic Alteration | 1 |
Inflammation, Chronic Active | 1 1 1 2 1 1 1 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 2| 7| 7| 6| 6| 4| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 5| 5| 5| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 7| 7| 4| 3| 5| 3| 3| 3|
| 0| 0| 0| 7| 5| 7| 7| 0| 0| 7| 0| 0| 6| 3| 2| 3| 0| 9| 1| 2| 3| 5| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation | |
Vacuolization Cytoplasmic | 3 |
Duct, Dilatation | |
Duct, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Sublingual Gland, Inflammation, | |
Chronic | 1 2 |
Submandibular Gland, Inflammation, | |
Chronic | 1 2 1 1 1 2 1 1 2 2 2 1 1 1 1 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 3 2 2 2 2 1 |
Erosion | 2 |
Hyperkeratosis | 1 1 2 1 1 1 1 |
Hyperplasia, Basal Cell | 1 2 2 |
Inflammation, Chronic Active | 1 2 1 2 1 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Mineralization | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hematopoietic Cell Proliferation | 2 2|
Hyperplasia | |
Inflammation, Chronic Active | 3 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + + + + M + + + M + + + + + + + + M M|
__________________________________________________________________________|
Pituitary Gland | + I + + + + + + + + + + I + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 2| 7| 7| 6| 6| 4| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 5| 5| 5| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 7| 7| 4| 3| 5| 3| 3| 3|
| 0| 0| 0| 7| 5| 7| 7| 0| 0| 7| 0| 0| 6| 3| 2| 3| 0| 9| 1| 2| 3| 5| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M |
__________________________________________________________________________|
Ovary | + + + + M M M + + + + + + + + + + + + + M + + +|
Abscess | 4 |
Angiectasis | 1 1 |
Cyst | 3 4 3 2 |
Cyst, Multiple | |
Hemorrhage | |
Mineralization | 1 1 |
Periovarian Tissue, Cyst | 2 |
Periovarian Tissue, Inflammation, | |
Chronic Active | 1 2 1 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hydrometra | 3 2 |
Inflammation, Acute | 2|
Inflammation, Chronic Active | 2 2 1 |
Endometrium, Hyperplasia | 3 2 3 2 2 3 1 2 3 3 1 2 3 2 1|
Epithelium, Metaplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 1 |
Myeloid Cell, Sternal, Hyperplasia | |
Sternal, Myelofibrosis | 2 2 2 2 2 2 1 2 1 2 2 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + M|
Depletion Lymphoid | 4 |
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
Pigmentation | 2 |
Sinus, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + M + + + + + + + + +|
Angiectasis | 1 2 2 |
Depletion Lymphoid | 3 |
Hemorrhage | 4|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 2| 7| 7| 6| 6| 4| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 5| 5| 5| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 7| 7| 4| 3| 5| 3| 3| 3|
| 0| 0| 0| 7| 5| 7| 7| 0| 0| 7| 0| 0| 6| 3| 2| 3| 0| 9| 1| 2| 3| 5| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 3 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 4|
Mineralization | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Hematopoietic Cell Proliferation | 4 2 3 2 2 4|
Hyperplasia, Lymphoid | 2 1 1 2 3 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + M M + + + + + + M + + + + + + M|
Cyst | 1 1 1 1 1 |
Depletion Lymphoid | 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + + + + + + M + + + M M M + M M M + + + M + +|
Hyperplasia | 1 1 1 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Cyst Epithelial | |
Inclusion | X |
Subcutaneous Tissue, Fibrosis | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 1 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + M M M + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perivascular, Inflammation, Chronic | 1 |
Thalamus, Mineralization | 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 |
Inflammation, Chronic Active | 1 1 1 2 |
Leukocytosis | 3|
Pleura, Inflammation, Acute | |
__________________________________________________________________________|
Nose | M + + + + + + + + + + M + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 4| 4| 7| 7| 7| 7| 7| 7| 5| 2| 7| 7| 6| 6| 4| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 5| 5| 5| 3| 3| 2| 3| 3| 0| 0| 0| 3| 3| 7| 7| 4| 3| 5| 3| 3| 3|
| 0| 0| 0| 7| 5| 7| 7| 0| 0| 7| 0| 0| 6| 3| 2| 3| 0| 9| 1| 2| 3| 5| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + M + + +|
Glomerulosclerosis | 1 3 |
Hydronephrosis | 2 |
Inflammation, Chronic | 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 2 1 1 2 |
Metaplasia, Osseous | 1 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Renal Tubule, Atrophy | |
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Regeneration | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic | 1 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 4| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| 5| 1| 5| 5| 3| 3| 5| | |
| 3| 3| 3| 7| 3| 5| 7| 3| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + M | 55 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 57 |
Autolysis | | 2 2.5|
Inflammation, Chronic Active | 1 | 6 1.2|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Autolysis | | 1 1.0|
Inflammation, Acute | | 1 2.0|
Peyer's Patch, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Autolysis | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
Autolysis | | 1 3.0|
Peyer's Patch, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Angiectasis | | 1 1.0|
Autolysis | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Autolysis | | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Autolysis | | 2 3.5|
Inflammation, Acute | | 1 1.0|
Peyer's Patch, Hyperplasia | | 3 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | 2 | 5 1.2|
Clear Cell Focus | 1 1 1 | 10 1.2|
Eosinophilic Focus | | 4 1.5|
Fatty Change | 2 | 4 1.3|
Hematopoietic Cell Proliferation | 2 | 6 1.8|
Inflammation, Acute | 1 | 5 1.0|
Inflammation, Chronic Active | 1 1 1 3 | 28 1.1|
Mixed Cell Focus | | 2 2.5|
Necrosis, Coagulative | 1 1 1 | 26 1.3|
Pigmentation | 1 1 1 1 2 1 1 1 1 2 | 54 1.1|
Bile Duct, Hyperplasia, Focal | 1 | 1 1.0|
Bile Duct, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 9 |
Fibrosis | 1 | 4 1.3|
Inflammation, Chronic Active | 1 | 5 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 4| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| 5| 1| 5| 5| 3| 3| 5| | |
| 3| 3| 3| 7| 3| 5| 7| 3| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Necrosis, Coagulative | | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | | 1 2.0|
Cytoplasmic Alteration | | 1 1.0|
Inflammation, Chronic Active | 2 1 2 | 24 1.3|
Inflammation | | 1 1.0|
Vacuolization Cytoplasmic | 2 1 1 1 | 13 1.4|
Duct, Dilatation | | 1 2.0|
Duct, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 1.0|
Sublingual Gland, Inflammation, | | |
Chronic | | 2 1.5|
Submandibular Gland, Inflammation, | | |
Chronic | 1 1 1 1 1 1 | 32 1.2|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Acanthosis | 1 2 | 16 1.6|
Erosion | | 1 2.0|
Hyperkeratosis | 1 2 1 | 16 1.4|
Hyperplasia, Basal Cell | 1 | 7 1.4|
Inflammation, Chronic Active | | 11 1.4|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 1 | 19 1.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Inflammation, Chronic | 1 1 | 6 1.2|
Mineralization | | 1 1.0|
Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + M + + + + + | 59 |
Cyst | | 1 2.0|
Hematopoietic Cell Proliferation | | 3 1.7|
Hyperplasia | | 1 1.0|
Inflammation, Chronic Active | | 1 3.0|
Vacuolization Cytoplasmic | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 4| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| 5| 1| 5| 5| 3| 3| 5| | |
| 3| 3| 3| 7| 3| 5| 7| 3| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + M + + + + + | 59 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 55 |
Pars Distalis, Hyperplasia | 1 2 1 1 1 | 22 1.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 2 1.5|
C-Cell, Hyperplasia | 1 | 1 1.0|
Follicular Cell, Hyperplasia | 1 | 19 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | |
__________________________________________________________________________|____________|
Ovary | + + + M + M M + + + | 51 |
Abscess | | 3 3.7|
Angiectasis | | 4 1.5|
Cyst | 2 2 | 12 2.5|
Cyst, Multiple | 1 | 3 1.7|
Hemorrhage | 2 | 1 2.0|
Mineralization | | 2 1.0|
Periovarian Tissue, Cyst | | 2 1.5|
Periovarian Tissue, Inflammation, | | |
Chronic Active | 2 1 | 24 1.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Fibrosis | | 2 2.0|
Hydrometra | | 3 2.7|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | 2 | 6 1.7|
Endometrium, Hyperplasia | 2 2 3 2 1 | 36 1.9|
Epithelium, Metaplasia, Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Myelofibrosis | 1 | 5 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 4| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| 5| 1| 5| 5| 3| 3| 5| | |
| 3| 3| 3| 7| 3| 5| 7| 3| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Myeloid Cell, Sternal, Hyperplasia | 2 | 1 2.0|
Sternal, Myelofibrosis | 2 1 2 1 | 32 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + | 12 |
Pancreatic, Hyperplasia, Lymphoid | | 1 1.0|
Renal, Hyperplasia, Plasma Cell | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 55 |
Depletion Lymphoid | | 1 4.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Acute | 2 | 1 2.0|
Pigmentation | | 2 2.0|
Sinus, Ectasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 56 |
Angiectasis | | 4 1.5|
Depletion Lymphoid | | 1 3.0|
Hemorrhage | | 2 2.5|
Hyperplasia, Lymphoid | | 6 2.5|
Infiltration Cellular, Histiocyte | 1 1 1 | 24 1.0|
Inflammation, Chronic Active | 2 | 3 2.3|
Mineralization | 1 | 1 1.0|
Pigmentation | 1 1 1 | 24 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Depletion Lymphoid | | 2 2.5|
Hematopoietic Cell Proliferation | 2 2 | 13 2.5|
Hyperplasia, Lymphoid | 1 2 | 14 1.6|
__________________________________________________________________________|____________|
Thymus | M + + + M + + + + + | 48 |
Cyst | 1 | 16 1.0|
Depletion Lymphoid | 2 | 2 2.5|
Hemorrhage | 1 | 1 1.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M + M + + M + + | 35 |
Hyperplasia | 2 2 | 9 1.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Cyst Epithelial | | |
Inclusion | | 1 |
Subcutaneous Tissue, Fibrosis | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 4| 4| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| 5| 1| 5| 5| 3| 3| 5| | |
| 3| 3| 3| 7| 3| 5| 7| 3| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + M + M M + + + | 48 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Perivascular, Inflammation, Chronic | | 1 1.0|
Thalamus, Mineralization | 1 1 | 15 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | | 4 1.3|
Inflammation, Chronic Active | | 4 1.3|
Leukocytosis | | 1 3.0|
Pleura, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 55 |
Inflammation, Acute | 1 1 | 9 1.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + M + M + + + + | 54 |
Glomerulosclerosis | | 3 1.7|
Hydronephrosis | | 1 2.0|
Inflammation, Chronic | 1 1 1 1 2 1 | 46 1.2|
Metaplasia, Osseous | 1 | 3 1.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 2 | 1 2.0|
Renal Tubule, Atrophy | | 1 1.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 | 43 1.0|
Renal Tubule, Regeneration | 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Inflammation, Chronic | 1 | 7 1.0|
Inflammation, Chronic Active | 1 1 2 1 1 1 | 43 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 5| 6| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 1| 1| 2| 2| 2| 2| 5| 2| 2| 2| 0| 2| 2| 2| 5| 2| 2| 5| 3| 3| 3| 2|
| 9| 9| 9| 8| 3| 9| 9| 9| 9| 7| 9| 3| 3| 1| 3| 9| 9| 7| 9| 9| 5| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + M + +|
Autolysis | 4 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Peyer's Patch, Hyperplasia | 4 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + A + + + + + + + + + + +|
Autolysis | |
Peyer's Patch, Hyperplasia | |
Peyer's Patch, Inflammation, Acute | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Basophilic Focus | 2 1 1 1 |
Clear Cell Focus | 1 1 1 1 2 3 |
Eosinophilic Focus | 1 4 |
Fatty Change | 1 1 1 2 1 1 1 1|
Fibrosis | |
Hematopoietic Cell Proliferation | 1 2 1|
Hemorrhage | 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 |
Necrosis, Coagulative | 3 1 1 1 1 1 |
Pigmentation | 2 2 1 2 2 2 2 2 2 2 1 1 1 2 2 1 2 2 1 2 1 2 1|
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Chronic Active | 4 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Autolysis | 4 |
Fibrosis | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 2 1 1 1 1 |
Vacuolization Cytoplasmic | 1 1 1 1 2 1 1 1 1 1|
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 5| 6| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 1| 1| 2| 2| 2| 2| 5| 2| 2| 2| 0| 2| 2| 2| 5| 2| 2| 5| 3| 3| 3| 2|
| 9| 9| 9| 8| 3| 9| 9| 9| 9| 7| 9| 3| 3| 1| 3| 9| 9| 7| 9| 9| 5| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Parotid Gland, Autolysis | 3 |
Submandibular Gland, Autolysis | 3 |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 2 2 2 2 2 |
Autolysis | 4 |
Erosion | |
Hyperkeratosis | 1 1 1 2 1 2 |
Hyperplasia, Basal Cell | 2 1 |
Hyperplasia, Squamous | 4 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 1 1 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic | 1 1 1 1 1|
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + M + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Degeneration, Fatty | |
Hematopoietic Cell Proliferation | |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + M + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M M + + M M + + + + M M + M + + M + + + M +|
__________________________________________________________________________|
Pituitary Gland | M + + + M + + + + + + + + + + + + + + M + M + M +|
Autolysis | 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 5| 6| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 1| 1| 2| 2| 2| 2| 5| 2| 2| 2| 0| 2| 2| 2| 5| 2| 2| 5| 3| 3| 3| 2|
| 9| 9| 9| 8| 3| 9| 9| 9| 9| 7| 9| 3| 3| 1| 3| 9| 9| 7| 9| 9| 5| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Ovary | + + + M M + + + + + + + + + + + M + + + + + + + +|
Abscess | 4 |
Angiectasis | 2 |
Cyst | 4 2 2 2 2 |
Cyst, Multiple | |
Periovarian Tissue, Cyst, Multiple | |
Periovarian Tissue, Hemorrhage | |
Periovarian Tissue, Inflammation, | |
Chronic Active | 1 1 1 1 1 1 2 1 1 1 1|
Periovarian Tissue, Pigmentation | |
__________________________________________________________________________|
Uterus | + + + A + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Fibrosis | |
Hydrometra | 2 2 |
Inflammation, Chronic Active | 1 1 1 1 |
Endometrium, Hyperplasia | 2 2 2 3 2 1 1 2 2 2 2 2 2 2 1 2 1 1|
Epithelium, Metaplasia, Squamous | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
Myeloid Cell, Sternal, Hyperplasia | 4 |
Sternal, Autolysis | 4 |
Sternal, Myelofibrosis | 2 3 1 2 1 2 2 2 3 X 2 3 2 1 1 1|
__________________________________________________________________________|
Lymph Node | + + + + + |
Lumbar, Hyperplasia, Lymphoid | 1 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Plasma Cell| 2 |
Pancreatic, Hyperplasia, Lymphoid | 4 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 5| 6| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 1| 1| 2| 2| 2| 2| 5| 2| 2| 2| 0| 2| 2| 2| 5| 2| 2| 5| 3| 3| 3| 2|
| 9| 9| 9| 8| 3| 9| 9| 9| 9| 7| 9| 3| 3| 1| 3| 9| 9| 7| 9| 9| 5| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Sinus, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + I + + + M M + + M + + M M + M|
Autolysis | 4 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + M + + + + + + + + + + + + + + M + + +|
Angiectasis | 2 |
Hyperplasia, Lymphoid | 2 2 2 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 3 3 3 2|
Hyperplasia, Lymphoid | 2 1 3 |
__________________________________________________________________________|
Thymus | M + + M M M + + + M + + + M + + + + + + + + + + +|
Cyst | 1 1 1 1 2 1 1 1 1 1 1 1|
Depletion Lymphoid | 2 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M M M + M M + M M + + + + M + M M + M + M M|
Hyperplasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Epidermis, Inflammation, Acute | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 5| 6| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 1| 1| 2| 2| 2| 2| 5| 2| 2| 2| 0| 2| 2| 2| 5| 2| 2| 5| 3| 3| 3| 2|
| 9| 9| 9| 8| 3| 9| 9| 9| 9| 7| 9| 3| 3| 1| 3| 9| 9| 7| 9| 9| 5| 0| 0| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Autolysis | 3 |
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic Active | 1 2 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + M + + + + M + + + + + + + + + + + + + M M +|
Inflammation, Acute | 1 1 1 |
Glands, Inflammation, Acute | |
__________________________________________________________________________|
Trachea | I + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | 3 |
Cornea, Neovascularization | 2 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Glomerulosclerosis | 2 2 |
Inflammation, Chronic | 2 2 2 1 1 2 2 1 1 1 1 1 1 X 1 1 1 1 1 1 1 1|
Metaplasia, Osseous | 1 |
Papilla, Mineralization | |
Renal Tubule, Atrophy | 1 |
Renal Tubule, Mineralization | 2 1 |
Renal Tubule, Pigmentation | 1 1 1 1 1 2 1 1 1 1 1 1 X 1 1 1 1 1 1|
Renal Tubule, Regeneration | 1 |
Transitional Epithelium, | |
Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Arteriole, Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 4| 4| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 8| 5| 3| 3| 3| 5| 5| 2| 2| 2| 2| 2| 3| 5| 3| 9| 6| 5| 5| 3| 3| 6|
| 0| 0| 0| 0| 7| 0| 0| 0| 3| 7| 9| 9| 9| 9| 9| 0| 5| 0| 7| 2| 5| 7| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + M + + + + + + + + + + + + + + + M|
Autolysis | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + M + + M + + + + + + + + + + + M M|
Autolysis | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + +|
Autolysis | 3|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + +|
Autolysis | 4|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + +|
Autolysis | 2|
Peyer's Patch, Hyperplasia | |
Peyer's Patch, Inflammation, Acute | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Basophilic Focus | 1|
Clear Cell Focus | 2 2 |
Eosinophilic Focus | |
Fatty Change | 2 1 2 1 1 |
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 2|
Hemorrhage | |
Inflammation, Acute | 2 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 2 1 1 1 |
Necrosis, Coagulative | 1 2 2 1 1 1 1 1 1 1 2 1 1 1 2|
Pigmentation | 1 2 1 2 1 2 1 1 1 1 2 2 1 2 2 2 1 2 2 1 1 1 2 2 1|
__________________________________________________________________________|
Mesentery | + +|
Inflammation, Chronic Active | 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Autolysis | 2|
Fibrosis | 4 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 2 1 1 4|
Vacuolization Cytoplasmic | 1 1 1 1 1 1 2 1|
Duct, Dilatation | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + M|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 4| 4| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 8| 5| 3| 3| 3| 5| 5| 2| 2| 2| 2| 2| 3| 5| 3| 9| 6| 5| 5| 3| 3| 6|
| 0| 0| 0| 0| 7| 0| 0| 0| 3| 7| 9| 9| 9| 9| 9| 0| 5| 0| 7| 2| 5| 7| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Parotid Gland, Autolysis | |
Submandibular Gland, Autolysis | |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 2 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 1 1 1 2 2 1 2 2 3 2 1 2 1|
Autolysis | |
Erosion | |
Hyperkeratosis | 1 1 1 1 1 1 2 2 3 2 2 2 1|
Hyperplasia, Basal Cell | 2 |
Hyperplasia, Squamous | |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 1 1 1 1 2 2 1 2 2 2 1|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 1 1 1 1 1 2 2 1 1 1|
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + M + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic | 1 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Degeneration, Fatty | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hematopoietic Cell Proliferation | 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1|
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + + M + + M + + + M + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + M + + + + + + + M|
Autolysis | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + M|
Autolysis | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 4| 4| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 8| 5| 3| 3| 3| 5| 5| 2| 2| 2| 2| 2| 3| 5| 3| 9| 6| 5| 5| 3| 3| 6|
| 0| 0| 0| 0| 7| 0| 0| 0| 3| 7| 9| 9| 9| 9| 9| 0| 5| 0| 7| 2| 5| 7| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Inflammation, Chronic Active | 1 |
C-Cell, Hyperplasia | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4|
Angiectasis | 3 3 4 |
Cyst | 3 3 2 |
Cyst, Multiple | |
Periovarian Tissue, Cyst, Multiple | 3 |
Periovarian Tissue, Hemorrhage | 4 |
Periovarian Tissue, Inflammation, | |
Chronic Active | 1 1 1 1 1 1 2 1 1 1 1 1 1|
Periovarian Tissue, Pigmentation | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Fibrosis | 2 |
Hydrometra | 3 |
Inflammation, Chronic Active | 1 |
Endometrium, Hyperplasia | 2 2 2 1 1 2 2 3 2 2 1 2 2 2 2 2 3 1 2|
Epithelium, Metaplasia, Squamous | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + M + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 |
Myeloid Cell, Sternal, Hyperplasia | |
Sternal, Autolysis | |
Sternal, Myelofibrosis | 2 2 2 1 3 2 X 2 2 3 2 2 1 |
__________________________________________________________________________|
Lymph Node | + + + + |
Lumbar, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 4| 4| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 8| 5| 3| 3| 3| 5| 5| 2| 2| 2| 2| 2| 3| 5| 3| 9| 6| 5| 5| 3| 3| 6|
| 0| 0| 0| 0| 7| 0| 0| 0| 3| 7| 9| 9| 9| 9| 9| 0| 5| 0| 7| 2| 5| 7| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + M + + M + M I + + M + + + + + + + I M M|
Autolysis | |
Hyperplasia, Lymphoid | 1 |
Hyperplasia, Plasma Cell | |
Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M M + + + + + + M + + + + + + + M|
Angiectasis | 1 |
Hyperplasia, Lymphoid | 2 2 1 1 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Depletion Lymphoid | 2 2 2|
Hematopoietic Cell Proliferation | 2 2 3|
Hyperplasia, Lymphoid | 1 2 1 |
__________________________________________________________________________|
Thymus | + + + M + + + + M + + + + + + M + M M + + + M + M|
Cyst | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 |
Depletion Lymphoid | 4 1 3 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M + M M + M + + M M + + M + M + M + + M + +|
Hyperplasia | 2 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Epidermis, Inflammation, Acute | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 4| 4| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 8| 5| 3| 3| 3| 5| 5| 2| 2| 2| 2| 2| 3| 5| 3| 9| 6| 5| 5| 3| 3| 6|
| 0| 0| 0| 0| 7| 0| 0| 0| 3| 7| 9| 9| 9| 9| 9| 0| 5| 0| 7| 2| 5| 7| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2.0% | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Autolysis | |
Hemorrhage | 2 1 1 2 2 |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic Active | 1 2 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + M + + + + + + M + + + + + + + + + + + +|
Inflammation, Acute | 1 1 1 |
Glands, Inflammation, Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + M + + + + + + + + + + + + + + + M|
Autolysis | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic Active | |
Cornea, Neovascularization | |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Glomerulosclerosis | 2 3 |
Inflammation, Chronic | 1 1 1 1 1 2 1 2 1 1 X 1 1 1 2 2 1 1 2 1 2 1 1|
Metaplasia, Osseous | |
Papilla, Mineralization | |
Renal Tubule, Atrophy | |
Renal Tubule, Mineralization | 2 |
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1|
Renal Tubule, Regeneration | 1 |
Transitional Epithelium, | |
Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3|
Inflammation, Chronic | 1 1 1 2 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1|
Arteriole, Necrosis, Fibrinoid | 2 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 5| 5| 4| 4| 7| 7| 6| | |
DAY ON TEST | 3| 6| 9| 6| 3| 5| 5| 3| 2| 3| | |
| 0| 4| 6| 8| 8| 7| 7| 0| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 57 |
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + + | 54 |
Autolysis | 3 | 2 3.5|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 | 8 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
Peyer's Patch, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + | 56 |
Autolysis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + | 56 |
Autolysis | 4 | 2 4.0|
Peyer's Patch, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 56 |
Autolysis | 2 | 2 2.0|
Peyer's Patch, Hyperplasia | 2 | 1 2.0|
Peyer's Patch, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
Basophilic Focus | 1 | 6 1.2|
Clear Cell Focus | 1 | 9 1.6|
Eosinophilic Focus | | 2 2.5|
Fatty Change | 1 2 1 1 1 | 18 1.2|
Fibrosis | | 1 1.0|
Hematopoietic Cell Proliferation | 1 2 | 6 1.5|
Hemorrhage | | 1 2.0|
Inflammation, Acute | 1 | 4 1.3|
Inflammation, Chronic Active | 2 2 1 1 | 29 1.1|
Necrosis, Coagulative | 2 1 2 2 | 25 1.4|
Pigmentation | 2 2 1 1 1 1 1 1 2 1 | 58 1.5|
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Inflammation, Chronic Active | | 4 2.8|
__________________________________________________________________________|____________|
Pancreas | + + M + + + + + + + | 59 |
Atrophy | 1 | 2 1.5|
Autolysis | | 2 3.0|
Fibrosis | | 1 4.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 5| 5| 4| 4| 7| 7| 6| | |
DAY ON TEST | 3| 6| 9| 6| 3| 5| 5| 3| 2| 3| | |
| 0| 4| 6| 8| 8| 7| 7| 0| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 1 2 1 1 2 1 | 18 1.4|
Vacuolization Cytoplasmic | 2 2 1 | 21 1.2|
Duct, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + M + + | 57 |
Inflammation, Chronic | 1 1 | 5 1.0|
Parotid Gland, Autolysis | | 1 3.0|
Submandibular Gland, Autolysis | | 1 3.0|
Submandibular Gland, Inflammation, | | |
Chronic | 1 2 2 1 2 | 33 1.2|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Acanthosis | 2 3 2 2 2 | 27 1.7|
Autolysis | | 1 4.0|
Erosion | 2 | 1 2.0|
Hyperkeratosis | 2 3 2 2 2 | 24 1.6|
Hyperplasia, Basal Cell | 2 1 | 5 1.6|
Hyperplasia, Squamous | | 2 3.0|
Inflammation, Chronic | 1 | 2 1.5|
Inflammation, Chronic Active | 3 2 2 2 | 24 1.7|
Ulcer | 2 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Autolysis | | 1 4.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | 2 1 1 1 | 21 1.1|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Autolysis | | 1 3.0|
Inflammation, Chronic | 1 | 8 1.0|
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
Autolysis | | 1 4.0|
Degeneration, Fatty | | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
Autolysis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 5| 5| 4| 4| 7| 7| 6| | |
DAY ON TEST | 3| 6| 9| 6| 3| 5| 5| 3| 2| 3| | |
| 0| 4| 6| 8| 8| 7| 7| 0| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + M + + + + + | 48 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M + + + + + | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 52 |
Autolysis | | 1 3.0|
Pars Distalis, Cyst | 1 | 1 1.0|
Pars Distalis, Hyperplasia | 2 | 8 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 58 |
Autolysis | | 1 4.0|
Inflammation, Chronic Active | 1 1 | 3 1.0|
C-Cell, Hyperplasia | | 1 1.0|
Follicle, Cyst | 2 | 2 2.0|
Follicular Cell, Hyperplasia | 1 1 | 18 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 57 |
Abscess | | 2 4.0|
Angiectasis | | 4 3.0|
Cyst | 1 | 9 2.3|
Cyst, Multiple | 2 | 1 2.0|
Periovarian Tissue, Cyst, Multiple | | 1 3.0|
Periovarian Tissue, Hemorrhage | | 1 4.0|
Periovarian Tissue, Inflammation, | | |
Chronic Active | 2 2 1 2 | 28 1.2|
Periovarian Tissue, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Angiectasis | | 1 3.0|
Fibrosis | | 1 2.0|
Hydrometra | | 3 2.3|
Inflammation, Chronic Active | 1 1 | 7 1.0|
Endometrium, Hyperplasia | 2 2 2 2 2 2 2 3 | 45 1.9|
Epithelium, Metaplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 5| 5| 4| 4| 7| 7| 6| | |
DAY ON TEST | 3| 6| 9| 6| 3| 5| 5| 3| 2| 3| | |
| 0| 4| 6| 8| 8| 7| 7| 0| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Myelofibrosis | | 1 1.0|
Myeloid Cell, Sternal, Hyperplasia | 3 | 2 3.5|
Sternal, Autolysis | | 1 4.0|
Sternal, Myelofibrosis | 2 1 1 1 1 | 34 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + | 12 |
Lumbar, Hyperplasia, Lymphoid | | 1 1.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 4.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 1 | 1 1.0|
Pancreatic, Pigmentation | 1 | 1 1.0|
Renal, Sinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M + + + + M + + | 41 |
Autolysis | | 1 4.0|
Hyperplasia, Lymphoid | | 2 2.0|
Hyperplasia, Plasma Cell | | 1 3.0|
Pigmentation | 1 | 3 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + | 52 |
Angiectasis | 2 | 3 1.7|
Hyperplasia, Lymphoid | 2 | 10 1.7|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 | 34 1.0|
Inflammation, Chronic Active | 2 2 | 2 2.0|
Pigmentation | 1 1 1 1 1 | 34 1.0|
Sinus, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + I + + + | 59 |
Autolysis | | 1 4.0|
Depletion Lymphoid | | 3 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 | 11 2.4|
Hyperplasia, Lymphoid | 2 2 | 8 1.8|
__________________________________________________________________________|____________|
Thymus | + M M M + + M + M + | 42 |
Cyst | 1 | 28 1.1|
Depletion Lymphoid | 2 | 6 2.5|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 5| 5| 4| 4| 7| 7| 6| | |
DAY ON TEST | 3| 6| 9| 6| 3| 5| 5| 3| 2| 3| | |
| 0| 4| 6| 8| 8| 7| 7| 0| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M + + + + M M M | 30 |
Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Epidermis, Inflammation, Acute | 1 | 1 1.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Thalamus, Mineralization | 1 1 1 1 | 25 1.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Autolysis | | 1 3.0|
Hemorrhage | 1 | 8 1.4|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Chronic Active | 1 1 | 6 1.3|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + I + + + | 53 |
Inflammation, Acute | 1 | 7 1.0|
Glands, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 57 |
Autolysis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Chronic Active | | 1 3.0|
Cornea, Neovascularization | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Inflammation, Chronic | | 2 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 5| 5| 4| 4| 7| 7| 6| | |
DAY ON TEST | 3| 6| 9| 6| 3| 5| 5| 3| 2| 3| | |
| 0| 4| 6| 8| 8| 7| 7| 0| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2.0% | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
Glomerulosclerosis | | 4 2.3|
Inflammation, Chronic | 1 2 1 1 1 2 1 1 2 | 54 1.3|
Metaplasia, Osseous | | 1 1.0|
Papilla, Mineralization | 2 | 1 2.0|
Renal Tubule, Atrophy | 2 1 | 3 1.3|
Renal Tubule, Mineralization | | 3 1.7|
Renal Tubule, Pigmentation | 1 2 2 2 1 2 | 43 1.2|
Renal Tubule, Regeneration | 2 1 | 4 1.3|
Transitional Epithelium, | | |
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Autolysis | | 2 3.5|
Inflammation, Chronic | 1 1 | 8 1.1|
Inflammation, Chronic Active | 1 1 1 1 1 2 1 | 46 1.0|
Arteriole, Necrosis, Fibrinoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 4| 7| 7| 2| 7| 7| 5| 4| 3| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 3| 2| 3| 6| 3| 3| 9| 3| 2| 2| 8| 9| 3| 6| 0| 3| 4| 3| 3| 3| 3| 3|
| 2| 2| 0| 2| 1| 0| 0| 0| 1| 2| 2| 3| 1| 0| 3| 1| 0| 5| 1| 5| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 71UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + A + + + + +|
Autolysis | |
Inflammation, Chronic Active | 1 2 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic Active | 2 |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M M + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + M + + + + + + + + + + +|
Autolysis | 3 |
Ulcer, Acute | |
Peyer's Patch, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Acute, Necrotizing | 3 |
Peyer's Patch, Hyperplasia, Lymphoid | |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Clear Cell Focus | 1 1 1 |
Cytoplasmic Alteration | |
Fatty Change | 2 1 1 1 3 |
Hematopoietic Cell Proliferation | 1 |
Inflammation, Acute | 1 |
Inflammation, Chronic Active | 1 2 1 1 1 3 1 1 |
Mineralization | |
Necrosis, Coagulative | 2 1 3 1 1 |
Pigmentation | |
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Autolysis | 3 |
Cytoplasmic Alteration | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 |
Vacuolization Cytoplasmic | 1 2 1 2 2 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 4| 7| 7| 2| 7| 7| 5| 4| 3| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 3| 2| 3| 6| 3| 3| 9| 3| 2| 2| 8| 9| 3| 6| 0| 3| 4| 3| 3| 3| 3| 3|
| 2| 2| 0| 2| 1| 0| 0| 0| 1| 2| 2| 3| 1| 0| 3| 1| 0| 5| 1| 5| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 71UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 |
Parotid Gland, Inflammation, Chronic | |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + M + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Autolysis | |
Edema | 2 |
Erosion | 1 |
Hyperkeratosis | 1 |
Inflammation, Chronic Active | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + M + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 |
Mineralization | 1 |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation, Chronic | 1 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Pigmentation | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + M M + + M M + M M M + + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + I + + M + M + + + + M + + M + + + I + + + + +|
Pars Distalis, Cyst | 1 2 |
Pars Distalis, Hyperplasia | 1 2 1 2 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ultimobranchial Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 4| 7| 7| 2| 7| 7| 5| 4| 3| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 3| 2| 3| 6| 3| 3| 9| 3| 2| 2| 8| 9| 3| 6| 0| 3| 4| 3| 3| 3| 3| 3|
| 2| 2| 0| 2| 1| 0| 0| 0| 1| 2| 2| 3| 1| 0| 3| 1| 0| 5| 1| 5| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 71UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + I + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Penis | |
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | + + + + + M + + + |
Abscess | |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 2 1 1 |
Duct, Dilatation | 4 3 2 4 3 |
__________________________________________________________________________|
Prostate | + + + + M + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1|
Artery, Inflammation, Chronic Active | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 1 |
Seminiferous Tubule, Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Sternal, Hyperplasia | 3 |
Sternal, Infiltration Cellular, Mast | |
Cell | |
__________________________________________________________________________|
Lymph Node | + + + + |
Inguinal, Hyperplasia, Lymphoid | |
Lumbar, Hyperplasia, Lymphoid | |
Lumbar, Hyperplasia | |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Pigmentation | |
Renal, Angiectasis | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + + M M + + M + M M + + + M + + + M M M + M|
Depletion Lymphoid | 2 4 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 4| 7| 7| 2| 7| 7| 5| 4| 3| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 3| 2| 3| 6| 3| 3| 9| 3| 2| 2| 8| 9| 3| 6| 0| 3| 4| 3| 3| 3| 3| 3|
| 2| 2| 0| 2| 1| 0| 0| 0| 1| 2| 2| 3| 1| 0| 3| 1| 0| 5| 1| 5| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 71UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + M M + + + +|
Angiectasis | 1 2 1 1 4 2 1 2 2 2 |
Depletion Lymphoid | |
Hemorrhage | 4 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 |
Pigmentation | 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 4 4 2 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Thymus | + + + + M M + M M M + + M + + M + + + + M + + + +|
Cyst | 1 |
Cyst, Multiple | |
Depletion Lymphoid | 3 |
Hyperplasia, Lymphoid | 3 |
Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M + M M M M M + M M M + M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | 1 |
Subcutaneous Tissue, Inflammation, | |
Acute | 2 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + M + + + + + + + + + M + + + + + + + +|
Cartilage, Tarsal, Hyperplasia | 2 |
Joint, Tarsal, Hyperostosis | 4 3 4 4 3 3 |
__________________________________________________________________________|
Skeletal Muscle | + + |
Fibrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Necrosis | 2 |
Cerebrum, Necrosis | 2 |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 4| 7| 7| 2| 7| 7| 5| 4| 3| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 3| 2| 3| 6| 3| 3| 9| 3| 2| 2| 8| 9| 3| 6| 0| 3| 4| 3| 3| 3| 3| 3|
| 2| 2| 0| 2| 1| 0| 0| 0| 1| 2| 2| 3| 1| 0| 3| 1| 0| 5| 1| 5| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 71UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemorrhage | 1 1 4 1 1|
Infiltration Cellular, Histiocyte | 3 2 |
Inflammation, Chronic Active | |
Mineralization | 1 |
Alveolar Epithelium, Hyperplasia | |
Bronchiole, Hyperplasia | |
Peribronchiolar, Inflammation, | |
Chronic | |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Crystals | |
Inflammation, Acute | 1 1 1 1 1 |
Glands, Crystals | |
Nasolacrimal Duct, Inflammation, | |
Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Inflammation, Chronic | 2 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 2 1 1 1|
Proximal Convoluted Renal Tubule, | |
Regeneration | |
Proximal Convoluted Renal Tubule, | |
Vacuolization Cytoplasmic | 2 |
Renal Tubule, Mineralization | |
Renal Tubule, Regeneration | 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Calculus Micro Observation Only | 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 2| 0| 6| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6|
| 1| 1| 1| 3| 5| 0| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 0| 2| 2| 1| 2| 8| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 71UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Ulcer, Acute | 4 |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Inflammation, Acute, Necrotizing | |
Peyer's Patch, Hyperplasia, Lymphoid | 4 |
Peyer's Patch, Hyperplasia | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | 2 |
Cytoplasmic Alteration | 2 |
Fatty Change | 2 1 1 1 2|
Hematopoietic Cell Proliferation | |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 4 3 1|
Mineralization | 1 |
Necrosis, Coagulative | 2 3 |
Pigmentation | 3 |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 |
Autolysis | |
Cytoplasmic Alteration | 1 1 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 |
Vacuolization Cytoplasmic | 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 2| 0| 6| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6|
| 1| 1| 1| 3| 5| 0| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 0| 2| 2| 1| 2| 8| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 71UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | |
Parotid Gland, Inflammation, Chronic | 1 1 |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 2 1 1 2 1 1 2 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Autolysis | 3 |
Edema | |
Erosion | |
Hyperkeratosis | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 |
Mineralization | 1 1 1 |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 |
Inflammation, Chronic | 1 1 1 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Pigmentation | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Acute | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 1 1 1|
__________________________________________________________________________|
Parathyroid Gland | M + + + M + M M + + + + + + + M + M + M M + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + M + + + + + + + + +|
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | 1 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Ultimobranchial Cyst | |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 2| 0| 6| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6|
| 1| 1| 1| 3| 5| 0| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 0| 2| 2| 1| 2| 8| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 71UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 3 1 2 1 1 4 1 1 1 1 1 1 |
__________________________________________________________________________|
Penis | + |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + |
Abscess | 4 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 3 3 2 1 1 4 4 2 |
Duct, Dilatation | 3 3 3 2 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1 |
Artery, Inflammation, Chronic Active | 4 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 2 1 1 1|
Seminiferous Tubule, Mineralization | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Sternal, Hyperplasia | |
Sternal, Infiltration Cellular, Mast | |
Cell | 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Inguinal, Hyperplasia, Lymphoid | 2 |
Lumbar, Hyperplasia, Lymphoid | |
Lumbar, Hyperplasia | 4 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 1 |
Pancreatic, Pigmentation | 1 |
Renal, Angiectasis | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + M + + + M + + + M + M + M + + M + + M + +|
Depletion Lymphoid | |
Hyperplasia, Lymphoid | 2 2 |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 2| 0| 6| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6|
| 1| 1| 1| 3| 5| 0| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 0| 2| 2| 1| 2| 8| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 71UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + M + + + + M + + +|
Angiectasis | 1 2 1 2 2 2 2 2 1 2 1 |
Depletion Lymphoid | 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | 1 2 2 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 3 4 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Thymus | + + + M M + + I + + + + + + + + + + + + + M + + M|
Cyst | 1 |
Cyst, Multiple | 1 |
Depletion Lymphoid | 3 |
Hyperplasia, Lymphoid | |
Pigmentation | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M + M M M M M M M + M M + M M M M + M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | 3 1 |
Subcutaneous Tissue, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + M + + + + + + + M + + M + + + + M + + M|
Cartilage, Tarsal, Hyperplasia | |
Joint, Tarsal, Hyperostosis | 4 3 4 |
__________________________________________________________________________|
Skeletal Muscle | + |
Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Necrosis | |
Cerebrum, Necrosis | |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 2| 0| 6| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3| 3| 3| 3| 5| 3| 3| 6|
| 1| 1| 1| 3| 5| 0| 1| 1| 1| 1| 2| 2| 2| 0| 2| 2| 0| 2| 2| 1| 2| 8| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 71UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hemorrhage | 1 1 1 1 |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic Active | 1 |
Mineralization | |
Alveolar Epithelium, Hyperplasia | 1 |
Bronchiole, Hyperplasia | 2 |
Peribronchiolar, Inflammation, | |
Chronic | 2 |
Perivascular, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + M + + M + + + + + + + + + + + + + + + + + + + +|
Crystals | 1 |
Inflammation, Acute | 1 2 2 1 1 1 |
Glands, Crystals | 1 1 |
Nasolacrimal Duct, Inflammation, | |
Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | 1 2 1 1 1|
Inflammation, Chronic Active | 1 2 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 |
Proximal Convoluted Renal Tubule, | |
Regeneration | 1 |
Proximal Convoluted Renal Tubule, | |
Vacuolization Cytoplasmic | |
Renal Tubule, Mineralization | 1 |
Renal Tubule, Regeneration | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + M + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Calculus Micro Observation Only | 2 X |
Inflammation, Chronic | 1 1|
Inflammation, Chronic Active | 1 1 1 1 1 1 2 1 1 4 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| | |
| 2| 2| 2| 1| 0| 0| 2| 2| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
D 71UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + M + + + | 56 |
Autolysis | | 1 4.0|
Inflammation, Chronic Active | 1 1 | 12 1.1|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
Peyer's Patch, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
Autolysis | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
Autolysis | | 2 2.5|
Ulcer, Acute | | 1 4.0|
Peyer's Patch, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Autolysis | | 2 3.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Autolysis | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Autolysis | | 2 3.5|
Inflammation, Acute, Necrotizing | | 1 3.0|
Peyer's Patch, Hyperplasia, Lymphoid | | 1 4.0|
Peyer's Patch, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 1.0|
Clear Cell Focus | | 4 1.3|
Cytoplasmic Alteration | | 1 2.0|
Fatty Change | 1 | 11 1.5|
Hematopoietic Cell Proliferation | | 1 1.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic Active | 1 3 1 | 15 1.7|
Mineralization | | 1 1.0|
Necrosis, Coagulative | 1 3 | 9 1.9|
Pigmentation | | 1 3.0|
Bile Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | | 2 1.0|
Autolysis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| | |
| 2| 2| 2| 1| 0| 0| 2| 2| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
D 71UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cytoplasmic Alteration | 1 1 | 4 1.0|
Inflammation, Chronic | | 2 1.0|
Inflammation, Chronic Active | 1 1 1 1 | 19 1.0|
Vacuolization Cytoplasmic | 1 1 1 1 1 2 | 20 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Chronic | 1 | 2 1.5|
Parotid Gland, Inflammation, Chronic | | 2 1.0|
Submandibular Gland, Inflammation, | | |
Chronic | 1 1 1 1 1 1 1 1 1 | 45 1.1|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Acanthosis | | 1 1.0|
Autolysis | | 1 3.0|
Edema | | 1 2.0|
Erosion | | 1 1.0|
Hyperkeratosis | | 2 1.5|
Inflammation, Chronic Active | | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Autolysis | | 1 4.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 1 2 1 1 | 15 1.1|
Mineralization | | 4 1.0|
__________________________________________________________________________|____________|
Tooth | + + + | 4 |
Dysplasia | 4 1 2 | 4 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 1 | 3 1.0|
Inflammation, Chronic | 1 2 | 7 1.1|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 1 1 | 3 1.0|
Pigmentation | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 1 1.0|
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 51 |
Hyperplasia | | 9 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| | |
| 2| 2| 2| 1| 0| 0| 2| 2| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
D 71UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + + + + + + | 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 52 |
Pars Distalis, Cyst | 1 2 | 5 1.4|
Pars Distalis, Hyperplasia | 1 2 | 13 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 1 1.0|
Ultimobranchial Cyst | 1 | 1 1.0|
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 59 |
Inflammation, Chronic Active | 1 1 2 1 1 | 30 1.2|
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + | 21 |
Abscess | | 1 4.0|
Inflammation, Chronic | | 2 1.5|
Inflammation, Chronic Active | 4 2 4 | 14 2.4|
Duct, Dilatation | 4 | 12 3.1|
__________________________________________________________________________|____________|
Prostate | + + + M + + + M + + | 57 |
Inflammation, Chronic | 1 1 | 5 1.0|
Inflammation, Chronic Active | 1 1 1 3 1 1 | 32 1.1|
Artery, Inflammation, Chronic Active | | 1 4.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
Inflammation, Chronic Active | 2 | 4 1.3|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Seminiferous Tubule, Atrophy | 1 1 | 7 1.1|
Seminiferous Tubule, Mineralization | | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Myeloid Cell, Sternal, Hyperplasia | | 1 3.0|
Sternal, Infiltration Cellular, Mast | | |
Cell | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| | |
| 2| 2| 2| 1| 0| 0| 2| 2| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
D 71UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + | 10 |
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Lumbar, Hyperplasia, Lymphoid | 3 | 1 3.0|
Lumbar, Hyperplasia | | 1 4.0|
Pancreatic, Hyperplasia, Lymphoid | | 2 2.5|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Pancreatic, Pigmentation | | 1 1.0|
Renal, Angiectasis | 1 | 1 1.0|
Renal, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + | 38 |
Depletion Lymphoid | 3 | 3 3.0|
Hyperplasia, Lymphoid | | 3 2.0|
Infiltration Cellular, Histiocyte | 1 1 | 3 1.0|
Inflammation, Chronic Active | | 1 2.0|
Pigmentation | 2 1 | 5 1.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 54 |
Angiectasis | 2 2 3 | 24 1.8|
Depletion Lymphoid | | 1 3.0|
Hemorrhage | | 1 4.0|
Hyperplasia, Lymphoid | 2 | 6 1.8|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 | 24 1.0|
Pigmentation | 1 1 1 1 1 1 | 23 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Angiectasis | | 1 1.0|
Depletion Lymphoid | | 1 2.0|
Hematopoietic Cell Proliferation | 3 | 6 3.3|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + M + I + | 44 |
Cyst | | 2 1.0|
Cyst, Multiple | 1 | 2 1.0|
Depletion Lymphoid | | 2 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Pigmentation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M + + M M M M | 11 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| | |
| 2| 2| 2| 1| 0| 0| 2| 2| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
D 71UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 1 | 4 1.5|
Subcutaneous Tissue, Inflammation, | | |
Acute | | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + M + + + + + | 51 |
Cartilage, Tarsal, Hyperplasia | | 1 2.0|
Joint, Tarsal, Hyperostosis | 2 4 4 | 12 3.5|
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Cerebellum, Necrosis | | 1 2.0|
Cerebrum, Necrosis | | 1 2.0|
Thalamus, Mineralization | 1 1 1 | 26 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Hemorrhage | | 9 1.3|
Infiltration Cellular, Histiocyte | | 2 2.5|
Inflammation, Chronic Active | | 1 1.0|
Mineralization | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Bronchiole, Hyperplasia | | 1 2.0|
Peribronchiolar, Inflammation, | | |
Chronic | | 1 2.0|
Perivascular, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Nose | M + + + + + M + M + | 53 |
Crystals | | 1 1.0|
Inflammation, Acute | 1 1 | 13 1.2|
Glands, Crystals | | 2 1.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Inflammation, Acute | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| | |
| 2| 2| 2| 1| 0| 0| 2| 2| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
D 71UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 1 1.0|
Inflammation, Chronic | 1 1 | 10 1.2|
Inflammation, Chronic Active | 2 2 1 1 1 1 1 1 | 47 1.2|
Proximal Convoluted Renal Tubule, | | |
Regeneration | 2 | 2 1.5|
Proximal Convoluted Renal Tubule, | | |
Vacuolization Cytoplasmic | | 1 2.0|
Renal Tubule, Mineralization | | 1 1.0|
Renal Tubule, Regeneration | 2 | 4 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Autolysis | | 2 3.0|
Calculus Micro Observation Only | 3 3 | 5 2.3|
Inflammation, Chronic | 1 | 3 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 | 37 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 4| 7| 6| 6| 7| 7| 6| 4| 6| 7| 6| 4| 5| 4| 7| 7| 4| 7| 5|
DAY ON TEST | 2| 2| 7| 7| 0| 3| 5| 3| 8| 1| 3| 3| 5| 6| 3| 3| 1| 5| 7| 5| 3| 3| 6| 3| 8|
| 9| 9| 3| 3| 5| 0| 8| 0| 9| 3| 0| 0| 4| 0| 3| 0| 2| 8| 2| 1| 0| 0| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Inflammation, Chronic Active | 1 1 1 2 1 1 1 |
Epithelium, Pigmentation | 1|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + M + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Epithelium, Hyperplasia | |
Peyer's Patch, Hyperplasia | |
Serosa, Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Autolysis | |
Peyer's Patch, Inflammation, Chronic,| |
Granulomatous | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + M A + + + + + + M + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | |
Inflammation, Acute | |
Peyer's Patch, Inflammation, Chronic,| |
Granulomatous | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | |
Peyer's Patch, Hyperplasia | 3 |
Peyer's Patch, Inflammation, Chronic,| |
Granulomatous | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | 1 |
Eosinophilic Focus | 3 1 1 1 |
Fatty Change | 1 2 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 1 2 1 |
Inflammation, Acute | 1 1 1 1 |
Inflammation, Chronic Active | 2 1 1 2 1 2 1 |
Mineralization | 2 |
Necrosis, Coagulative | 1 1 3 1 1 1 2 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 4| 7| 6| 6| 7| 7| 6| 4| 6| 7| 6| 4| 5| 4| 7| 7| 4| 7| 5|
DAY ON TEST | 2| 2| 7| 7| 0| 3| 5| 3| 8| 1| 3| 3| 5| 6| 3| 3| 1| 5| 7| 5| 3| 3| 6| 3| 8|
| 9| 9| 3| 3| 5| 0| 8| 0| 9| 3| 0| 0| 4| 0| 3| 0| 2| 8| 2| 1| 0| 0| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Nuclear Alteration | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1|
Bile Duct, Hyperplasia | 2 |
Centrilobular, Cytoplasmic Alteration| 3 3 2 3 |
Hepatocyte, Centrilobular, | |
Hypertrophy | 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 4 1 2|
Necrosis, Coagulative | 3 |
Thrombosis | 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Ectopic Liver | X |
Inflammation, Chronic Active | 1 3 1 4 1 1 1 |
Vacuolization Cytoplasmic | 2 1 1 2 1 1 1 1 2|
Acinus, Atrophy | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Sublingual Gland, Inflammation, | |
Chronic | |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Acanthosis | 1 1 1 2 |
Cyst | |
Diverticulum | |
Hyperkeratosis | 1 1 1 |
Hyperplasia, Basal Cell | |
Inflammation, Chronic Active | 2 1 |
Ulcer | 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 1 1 2 1 1 1 1 1 1 1 2|
Muscularis, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 1 1 1 1 |
Necrosis, Coagulative | |
Coronary Artery, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 4| 7| 6| 6| 7| 7| 6| 4| 6| 7| 6| 4| 5| 4| 7| 7| 4| 7| 5|
DAY ON TEST | 2| 2| 7| 7| 0| 3| 5| 3| 8| 1| 3| 3| 5| 6| 3| 3| 1| 5| 7| 5| 3| 3| 6| 3| 8|
| 9| 9| 3| 3| 5| 0| 8| 0| 9| 3| 0| 0| 4| 0| 3| 0| 2| 8| 2| 1| 0| 0| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Pigmentation | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + M + M + + M + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + M + + + + M +|
Pars Distalis, Cyst | 2 1 1 |
Pars Distalis, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ultimobranchial Cyst | |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Penis | + |
Hemorrhage | 2 |
__________________________________________________________________________|
Preputial Gland | M + + + +|
Abscess | |
Inflammation, Chronic Active | 1|
Duct, Dilatation | 2 4 3 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + M + + + + + + M + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | 2 |
Fibrosis | 2 |
Inflammation, Chronic Active | 1 1 2 1 1 1 |
Artery, Thrombosis | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 4| 7| 6| 6| 7| 7| 6| 4| 6| 7| 6| 4| 5| 4| 7| 7| 4| 7| 5|
DAY ON TEST | 2| 2| 7| 7| 0| 3| 5| 3| 8| 1| 3| 3| 5| 6| 3| 3| 1| 5| 7| 5| 3| 3| 6| 3| 8|
| 9| 9| 3| 3| 5| 0| 8| 0| 9| 3| 0| 0| 4| 0| 3| 0| 2| 8| 2| 1| 0| 0| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Sternal, Hyperplasia | 4 |
Sternal, Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node | + + + + +|
Lumbar, Hyperplasia, Lymphoid | 2 |
Lumbar, Inflammation, Chronic Active | 1 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | X|
Mediastinal, Pigmentation | 1|
Renal, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + + M + + + M + + + M + M M + + + + I + + + +|
Depletion Lymphoid | 3|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Inflammation, Chronic Active | |
Pigmentation | 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 1 1 |
Congestion | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 4 |
Hyperplasia, Plasma Cell | 3 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 3 2 3 3 2 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 3 3 4 3 4 2 4 2 2|
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | 2 |
Necrosis, Coagulative | 1 |
__________________________________________________________________________|
Thymus | + + M + M + + + M M + + + + + + M + M + + + + M +|
Cyst | |
Depletion Lymphoid | 3 2 3 3 |
Infiltration Cellular, Histiocyte | |
Necrosis, Coagulative | |
Pigmentation | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M + M M M M M M + M M M + M M M M + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic Active | 1 1 1 1 3 |
Subcutaneous Tissue, Cyst | 2 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 4| 7| 6| 6| 7| 7| 6| 4| 6| 7| 6| 4| 5| 4| 7| 7| 4| 7| 5|
DAY ON TEST | 2| 2| 7| 7| 0| 3| 5| 3| 8| 1| 3| 3| 5| 6| 3| 3| 1| 5| 7| 5| 3| 3| 6| 3| 8|
| 9| 9| 3| 3| 5| 0| 8| 0| 9| 3| 0| 0| 4| 0| 3| 0| 2| 8| 2| 1| 0| 0| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + M + + + + + + + + + + M + + + + M + +|
Joint, Tarsal, Hyperostosis | 3 3 4 4|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchiectasis | |
Crystals | |
Foreign Body | 1|
Granuloma | 1|
Hemorrhage | 1 1 2 1 1 |
Infiltration Cellular, Histiocyte | |
Inflammation, Acute | 1 |
Inflammation, Chronic Active | 2 |
Bronchiole, Metaplasia, Squamous | |
__________________________________________________________________________|
Nose | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Anterior, Synechia | |
Cornea, Fibrosis | |
__________________________________________________________________________|
Harderian Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + M + + + + + + M + + + M + + + + M + +|
Autolysis | |
Congestion | |
Glomerulosclerosis | 1 |
Infiltration Cellular, Mononuclear | |
Cell | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2|
Necrosis, Coagulative | 1 |
Artery, Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 4| 7| 6| 6| 7| 7| 6| 4| 6| 7| 6| 4| 5| 4| 7| 7| 4| 7| 5|
DAY ON TEST | 2| 2| 7| 7| 0| 3| 5| 3| 8| 1| 3| 3| 5| 6| 3| 3| 1| 5| 7| 5| 3| 3| 6| 3| 8|
| 9| 9| 3| 3| 5| 0| 8| 0| 9| 3| 0| 0| 4| 0| 3| 0| 2| 8| 2| 1| 0| 0| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Proximal Convoluted Renal Tubule, | |
Hyperplasia | |
Proximal Convoluted Renal Tubule, | |
Regeneration | |
Renal Tubule, Mineralization | 1 1 |
Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1|
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 4 |
Calculus Micro Observation Only | 2 2 |
Inflammation, Chronic | 1 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 |
Transitional Epithelium, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 4| 7| 6| 6| 1| 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 4| 7| 5| 4| 7| 7| 7| 5| 5|
DAY ON TEST | 5| 3| 4| 1| 5| 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 5| 5| 0| 5| 6| 3| 3| 1| 8| 7|
| 8| 0| 8| 8| 2| 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 8| 8| 6| 0| 0| 0| 0| 7| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + M + + + M + + + + + + + + + + + + + + + + + M|
Autolysis | 4 |
Inflammation, Chronic Active | 1 1 1 |
Epithelium, Pigmentation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + + + + + M|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 1 |
Epithelium, Hyperplasia | |
Peyer's Patch, Hyperplasia | |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Peyer's Patch, Inflammation, Chronic,| |
Granulomatous | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia, Lymphoid | |
Inflammation, Acute | 1 |
Peyer's Patch, Inflammation, Chronic,| |
Granulomatous | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia, Lymphoid | 1 |
Peyer's Patch, Hyperplasia | 2 |
Peyer's Patch, Inflammation, Chronic,| |
Granulomatous | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 1 1|
Clear Cell Focus | 1 |
Eosinophilic Focus | 2 1 |
Fatty Change | 1 |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Acute | 1 1 1 1 |
Inflammation, Chronic Active | 1 1 |
Mineralization | |
Necrosis, Coagulative | 1 2 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 4| 7| 6| 6| 1| 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 4| 7| 5| 4| 7| 7| 7| 5| 5|
DAY ON TEST | 5| 3| 4| 1| 5| 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 5| 5| 0| 5| 6| 3| 3| 1| 8| 7|
| 8| 0| 8| 8| 2| 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 8| 8| 6| 0| 0| 0| 0| 7| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Nuclear Alteration | 1 |
Pigmentation | 2 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Bile Duct, Hyperplasia | 2 |
Centrilobular, Cytoplasmic Alteration| 3 3 3 3 |
Hepatocyte, Centrilobular, | |
Hypertrophy | 2 2 2 2 3 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 |
Necrosis, Coagulative | |
Thrombosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + M +|
Autolysis | 4 |
Ectopic Liver | |
Inflammation, Chronic Active | 1 1 1 |
Vacuolization Cytoplasmic | 1 1 1 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sublingual Gland, Inflammation, | |
Chronic | 1 |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + M + + + + + + + + + + +|
Abscess | 1 |
Acanthosis | 1 1 1 1 |
Cyst | 1|
Diverticulum | |
Hyperkeratosis | 1 1 1 |
Hyperplasia, Basal Cell | 1 |
Inflammation, Chronic Active | 1 1 1 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + I + + + + + + + + + + +|
Infiltration Cellular, Mast Cell | 1 |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1|
Muscularis, Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 3 1 |
Necrosis, Coagulative | 2 |
Coronary Artery, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 4| 7| 6| 6| 1| 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 4| 7| 5| 4| 7| 7| 7| 5| 5|
DAY ON TEST | 5| 3| 4| 1| 5| 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 5| 5| 0| 5| 6| 3| 3| 1| 8| 7|
| 8| 0| 8| 8| 2| 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 8| 8| 6| 0| 0| 0| 0| 7| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | 2 |
Pigmentation | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + M M + M + M + M + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 2 1 1 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ultimobranchial Cyst | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Penis | |
Hemorrhage | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + |
Abscess | |
Inflammation, Chronic Active | 2 2 1 2 1 |
Duct, Dilatation | 4 2 2 4 2 4 |
__________________________________________________________________________|
Prostate | + + + M + + + + + + + + + + + + + + + + + I + +|
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 2 1|
Inflammation | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cyst | |
Fibrosis | 2 |
Inflammation, Chronic Active | 1 2 1 1 1 |
Artery, Thrombosis | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 |
Seminiferous Tubule, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 4| 7| 6| 6| 1| 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 4| 7| 5| 4| 7| 7| 7| 5| 5|
DAY ON TEST | 5| 3| 4| 1| 5| 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 5| 5| 0| 5| 6| 3| 3| 1| 8| 7|
| 8| 0| 8| 8| 2| 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 8| 8| 6| 0| 0| 0| 0| 7| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + M + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Sternal, Hyperplasia | 3 |
Sternal, Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node | + + |
Lumbar, Hyperplasia, Lymphoid | |
Lumbar, Inflammation, Chronic Active | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Pigmentation | |
Renal, Inflammation, Chronic Active | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M M + M + M M M + + + M + + + M + + + + + + +|
Depletion Lymphoid | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 |
Inflammation, Chronic Active | 3 |
Pigmentation | 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 2 3 1 |
Congestion | 1 |
Hematopoietic Cell Proliferation | 1 1 |
Hyperplasia, Lymphoid | 2 1 2 2 2 |
Hyperplasia, Plasma Cell | |
Infiltration Cellular, Histiocyte | 3 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 4 |
Pigmentation | 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 4 2 |
Hematopoietic Cell Proliferation | 4 3 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Thymus | + + + + + + + + M M + + + + + + M + + + + + M|
Cyst | 2 1 1 1 |
Depletion Lymphoid | 4 2 4 3 |
Infiltration Cellular, Histiocyte | 2 |
Necrosis, Coagulative | 2 |
Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M M M M M M M M M M M + + M M + M + M M M|
__________________________________________________________________________|
Skin | + + + + M + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 |
Subcutaneous Tissue, Cyst | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 4| 7| 6| 6| 1| 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 4| 7| 5| 4| 7| 7| 7| 5| 5|
DAY ON TEST | 5| 3| 4| 1| 5| 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 5| 5| 0| 5| 6| 3| 3| 1| 8| 7|
| 8| 0| 8| 8| 2| 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 8| 8| 6| 0| 0| 0| 0| 7| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | M + + + M + + + + + + + + + + M M + + M + + + + +|
Joint, Tarsal, Hyperostosis | 4 4 4 3 4|
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchiectasis | |
Crystals | 1 |
Foreign Body | |
Granuloma | |
Hemorrhage | 1 1 1 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | 1 1 |
Bronchiole, Metaplasia, Squamous | |
__________________________________________________________________________|
Nose | + + + + M + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Anterior, Synechia | 1 |
Cornea, Fibrosis | 2 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | M + + + + + + + + + + + + + + M + + + M + + + + +|
Autolysis | 2 |
Congestion | |
Glomerulosclerosis | 1 1 |
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 2 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1 |
Necrosis, Coagulative | |
Artery, Necrosis, Fibrinoid | 2 |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 4| 7| 6| 6| 1| 7| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 4| 7| 5| 4| 7| 7| 7| 5| 5|
DAY ON TEST | 5| 3| 4| 1| 5| 3| 3| 4| 3| 6| 5| 3| 0| 1| 0| 5| 5| 0| 5| 6| 3| 3| 1| 8| 7|
| 8| 0| 8| 8| 2| 0| 0| 7| 3| 4| 7| 0| 9| 1| 1| 8| 8| 6| 0| 0| 0| 0| 7| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
Proximal Convoluted Renal Tubule, | |
Hyperplasia | 1 |
Proximal Convoluted Renal Tubule, | |
Regeneration | 1 1 1 1 1 1 |
Renal Tubule, Mineralization | 1 1 |
Renal Tubule, Pigmentation | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + I + + + + + + + + + + + + + + +|
Autolysis | 3 |
Calculus Micro Observation Only | |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 5| 3| 1| 1| 3| 3| 3| 3| 4| | |
| 0| 8| 0| 5| 4| 0| 0| 0| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 56 |
Autolysis | | 2 4.0|
Inflammation, Chronic Active | 1 1 | 12 1.1|
Epithelium, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 58 |
Autolysis | | 2 3.5|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
Autolysis | | 2 3.5|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Autolysis | | 2 3.5|
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | | 1 1.0|
Epithelium, Hyperplasia | 1 | 1 1.0|
Peyer's Patch, Hyperplasia | 2 | 1 2.0|
Serosa, Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
Autolysis | | 1 4.0|
Peyer's Patch, Inflammation, Chronic,| | |
Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
Autolysis | | 1 4.0|
Hyperplasia, Lymphoid | 1 | 1 1.0|
Inflammation, Acute | | 1 1.0|
Peyer's Patch, Inflammation, Chronic,| | |
Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
Autolysis | | 1 4.0|
Hyperplasia, Lymphoid | | 1 1.0|
Peyer's Patch, Hyperplasia | | 2 2.5|
Peyer's Patch, Inflammation, Chronic,| | |
Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 4 1.0|
Clear Cell Focus | 1 1 | 4 1.0|
Eosinophilic Focus | | 6 1.5|
Fatty Change | 1 1 1 | 6 1.2|
Fibrosis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 5| 3| 1| 1| 3| 3| 3| 3| 4| | |
| 0| 8| 0| 5| 4| 0| 0| 0| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | | 5 1.6|
Inflammation, Acute | 1 | 9 1.0|
Inflammation, Chronic Active | 2 | 10 1.4|
Mineralization | | 1 2.0|
Necrosis, Coagulative | 1 1 | 20 1.3|
Nuclear Alteration | | 1 1.0|
Pigmentation | 1 1 1 1 2 1 2 1 1 1 | 59 1.1|
Bile Duct, Hyperplasia | | 2 2.0|
Centrilobular, Cytoplasmic Alteration| 3 | 9 2.9|
Hepatocyte, Centrilobular, | | |
Hypertrophy | 2 | 17 2.0|
__________________________________________________________________________|____________|
Mesentery | | 8 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 4 2.5|
Necrosis, Coagulative | | 1 3.0|
Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Autolysis | | 1 4.0|
Ectopic Liver | | 1 |
Inflammation, Chronic Active | 1 1 | 12 1.4|
Vacuolization Cytoplasmic | 1 1 2 2 1 1 | 18 1.3|
Acinus, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Sublingual Gland, Inflammation, | | |
Chronic | | 1 1.0|
Submandibular Gland, Inflammation, | | |
Chronic | 1 1 1 1 1 1 1 | 29 1.1|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Abscess | | 1 1.0|
Acanthosis | 1 1 1 | 11 1.1|
Cyst | | 1 1.0|
Diverticulum | 1 | 1 1.0|
Hyperkeratosis | 1 1 1 | 9 1.0|
Hyperplasia, Basal Cell | | 1 1.0|
Inflammation, Chronic Active | 1 | 6 1.2|
Ulcer | | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Infiltration Cellular, Mast Cell | | 1 1.0|
Inflammation, Chronic | | 5 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 5| 3| 1| 1| 3| 3| 3| 3| 4| | |
| 0| 8| 0| 5| 4| 0| 0| 0| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 1 1 1 | 24 1.1|
Muscularis, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Inflammation, Chronic | 1 1 | 17 1.2|
Necrosis, Coagulative | | 1 2.0|
Coronary Artery, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | 1 | 3 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Hyperplasia | | 1 2.0|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 50 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + M | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + | 54 |
Pars Distalis, Cyst | 1 | 4 1.3|
Pars Distalis, Hyperplasia | 2 | 9 1.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Inflammation, Chronic | 1 | 1 1.0|
Ultimobranchial Cyst | 1 | 1 1.0|
Follicular Cell, Hyperplasia | | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 1 1 1 1 | 21 1.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Penis | | 1 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 16 |
Abscess | 4 4 4 | 3 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 5| 3| 1| 1| 3| 3| 3| 3| 4| | |
| 0| 8| 0| 5| 4| 0| 0| 0| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 1 | 7 1.4|
Duct, Dilatation | | 10 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 55 |
Inflammation, Chronic Active | 1 1 1 1 1 1 2 | 29 1.1|
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
Atrophy | | 1 3.0|
Cyst | | 1 2.0|
Fibrosis | 1 | 3 1.7|
Inflammation, Chronic Active | 1 1 1 | 14 1.1|
Artery, Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 59 |
Interstitial Cell, Hyperplasia | | 1 1.0|
Seminiferous Tubule, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Myeloid Cell, Sternal, Hyperplasia | | 2 3.5|
Sternal, Inflammation, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 8 |
Lumbar, Hyperplasia, Lymphoid | | 1 2.0|
Lumbar, Inflammation, Chronic Active | | 1 1.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 |
Mediastinal, Pigmentation | | 1 1.0|
Renal, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + | 43 |
Depletion Lymphoid | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
Pigmentation | | 4 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + | 56 |
Angiectasis | 1 | 11 1.5|
Congestion | | 1 1.0|
Hematopoietic Cell Proliferation | | 2 1.0|
Hyperplasia, Lymphoid | 2 1 1 | 9 1.9|
Hyperplasia, Plasma Cell | | 1 3.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 | 22 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 5| 3| 1| 1| 3| 3| 3| 3| 4| | |
| 0| 8| 0| 5| 4| 0| 0| 0| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 7 2.6|
Pigmentation | 1 1 1 1 | 22 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Depletion Lymphoid | 1 | 3 2.3|
Hematopoietic Cell Proliferation | 3 2 3 | 14 3.0|
Hyperplasia, Lymphoid | 2 1 | 2 1.5|
Inflammation, Chronic Active | | 1 2.0|
Necrosis, Coagulative | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + M M + + + M + | 44 |
Cyst | 1 1 | 6 1.2|
Depletion Lymphoid | | 8 3.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Necrosis, Coagulative | | 1 2.0|
Pigmentation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M M M M M M | 10 |
__________________________________________________________________________|____________|
Skin | + + + + M + + + + + | 57 |
Inflammation, Chronic Active | 1 1 | 9 1.4|
Subcutaneous Tissue, Cyst | | 1 2.0|
Subcutaneous Tissue, Fibrosis | | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 52 |
Joint, Tarsal, Hyperostosis | 4 4 3 4 | 13 3.7|
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Thalamus, Mineralization | 1 1 1 | 20 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Bronchiectasis | 1 | 1 1.0|
Crystals | | 1 1.0|
Foreign Body | | 1 1.0|
Granuloma | | 1 1.0|
Hemorrhage | 1 | 9 1.1|
Infiltration Cellular, Histiocyte | 4 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 5| 3| 1| 1| 3| 3| 3| 3| 4| | |
| 0| 8| 0| 5| 4| 0| 0| 0| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.0% | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Acute | 2 | 2 1.5|
Inflammation, Chronic Active | | 3 1.3|
Bronchiole, Metaplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 58 |
Inflammation, Acute | 1 1 | 11 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Anterior, Synechia | | 1 1.0|
Cornea, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + M + + + + + + + + | 52 |
Autolysis | | 1 2.0|
Congestion | 1 | 1 1.0|
Glomerulosclerosis | | 3 1.0|
Infiltration Cellular, Mononuclear | | |
Cell | | 1 1.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 2 1 1 1 1 1 1 2 | 42 1.2|
Necrosis, Coagulative | | 1 1.0|
Artery, Necrosis, Fibrinoid | | 1 2.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 3 | 1 3.0|
Proximal Convoluted Renal Tubule, | | |
Hyperplasia | | 1 1.0|
Proximal Convoluted Renal Tubule, | | |
Regeneration | 1 1 1 1 1 | 11 1.0|
Renal Tubule, Mineralization | | 4 1.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 1 2 1 1 | 42 1.1|
Renal Tubule, Regeneration | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Autolysis | | 3 3.0|
Calculus Micro Observation Only | | 2 2.0|
Inflammation, Chronic | | 7 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 | 31 1.0|
Transitional Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 5| 4| 1| 4| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 4| 6| 6|
DAY ON TEST | 5| 2| 2| 2| 2| 4| 9| 8| 3| 5| 2| 2| 2| 2| 1| 2| 5| 2| 8| 4| 2| 2| 6| 2| 0|
| 8| 9| 9| 9| 9| 8| 3| 4| 6| 8| 9| 9| 9| 9| 3| 9| 8| 9| 9| 5| 9| 9| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + M + + M + + +|
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Mesothelium, Hyperplasia | 1 |
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Epithelium, Pigmentation | 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Focal | 2 |
Basophilic Focus | 1 1 1 |
Clear Cell Focus | 1 |
Eosinophilic Focus | 1 |
Fatty Change | 1 1 2 1 |
Hematopoietic Cell Proliferation | 1 1 |
Infarct | 4 |
Inflammation, Acute | 1 1 |
Inflammation, Chronic Active | 2 1 1 1 1 1 1 2 2 |
Karyomegaly | 3 |
Necrosis, Coagulative | 2 1 1 1 1 1 1 1 2 1 2 1 1 |
Pigmentation | 1 1 1 2 2 2 2 1 1 1 1 1 2 1 1 1 1 2 1 1 2 1 1 2|
Thrombosis | 1 |
Bile Duct, Hyperplasia | |
Centrilobular, Cytoplasmic Alteration| 3 3 |
Hepatocyte, Centrilobular, | |
Hypertrophy | 2 3 2 1 2 2 |
__________________________________________________________________________|
Mesentery | + |
Abscess | |
Fibrosis | |
Inflammation, Chronic Active | |
Mineralization | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + M + + + + + + + + + +|
Atrophy | 1 |
Cytoplasmic Alteration | |
Inflammation, Chronic Active | 1 1 |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 5| 4| 1| 4| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 4| 6| 6|
DAY ON TEST | 5| 2| 2| 2| 2| 4| 9| 8| 3| 5| 2| 2| 2| 2| 1| 2| 5| 2| 8| 4| 2| 2| 6| 2| 0|
| 8| 9| 9| 9| 9| 8| 3| 4| 6| 8| 9| 9| 9| 9| 3| 9| 8| 9| 9| 5| 9| 9| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Vacuolization Cytoplasmic | 2 |
Artery, Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Parotid Gland, Mineralization | 1 |
Sublingual Gland, Submandibular | |
Gland, Inflammation, Chronic | 1 |
Submandibular Gland, Atrophy | 1 |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 2 2 1 1 1 1 1 1 1 2 1 1 1 2 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 2 2 2 3 |
Hyperkeratosis | 2 1 2 1 2 |
Hyperplasia, Basal Cell | 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | 1 1 2 1 2 2 1 |
Inflammation, Chronic Active, | |
Necrotizing | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 1 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 2 1 1 1 2 1 |
Mineralization | 1 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + + + |
Dysplasia | 1 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Vacuolization Cytoplasmic | |
Capsule, Inflammation, Chronic Active| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + M + M + + + M + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + M + + + +|
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | 1 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 5| 4| 1| 4| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 4| 6| 6|
DAY ON TEST | 5| 2| 2| 2| 2| 4| 9| 8| 3| 5| 2| 2| 2| 2| 1| 2| 5| 2| 8| 4| 2| 2| 6| 2| 0|
| 8| 9| 9| 9| 9| 8| 3| 4| 6| 8| 9| 9| 9| 9| 3| 9| 8| 9| 9| 5| 9| 9| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 |
Serosa, Hyperplasia | |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + +|
Abscess | 4 3 |
Inflammation, Chronic Active | 2 1 2 2 |
Duct, Dilatation | 2 2 |
__________________________________________________________________________|
Prostate | M + + + + + M + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic Active | 1 1 1 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Inflammation, Chronic Active | |
Seminiferous Tubule, Atrophy | 1 1 |
Seminiferous Tubule, Mineralization | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Sternal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + +|
Hyperplasia, Lymphoid | |
Lumbar, Hyperplasia, Plasma Cell | 2 |
Mediastinal, Inflammation, Chronic | |
Active | |
Pancreatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M M + M + M M + M + + + M M + M + + + M|
Depletion Lymphoid | 4 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 5| 4| 1| 4| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 4| 6| 6|
DAY ON TEST | 5| 2| 2| 2| 2| 4| 9| 8| 3| 5| 2| 2| 2| 2| 1| 2| 5| 2| 8| 4| 2| 2| 6| 2| 0|
| 8| 9| 9| 9| 9| 8| 3| 4| 6| 8| 9| 9| 9| 9| 3| 9| 8| 9| 9| 5| 9| 9| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
Necrosis, Coagulative | |
Pigmentation | 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +|
Angiectasis | 1 2 1 2 2 2 2 2|
Depletion Lymphoid | |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
Hyperplasia | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | |
Pigmentation | 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Depletion Lymphoid | 1 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 4 2 2|
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Thymus | + + + M + M + M M + + + + + + + M + + M + I + + +|
Cyst | 1 1 1 1 1|
Depletion Lymphoid | 2 4 4|
Necrosis, Coagulative | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M M M M M M + M M M M M M + M M M M M + M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 1 1 1 |
Subcutaneous Tissue, Abscess | |
Subcutaneous Tissue, Fibrosis | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | 4 4 2 4 |
__________________________________________________________________________|
Skeletal Muscle | + |
Intercostal, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 2 |
Thalamus, Mineralization | 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 6| 5| 4| 1| 4| 7| 7| 7| 7| 6| 7| 4| 7| 6| 6| 7| 7| 4| 6| 6|
DAY ON TEST | 5| 2| 2| 2| 2| 4| 9| 8| 3| 5| 2| 2| 2| 2| 1| 2| 5| 2| 8| 4| 2| 2| 6| 2| 0|
| 8| 9| 9| 9| 9| 8| 3| 4| 6| 8| 9| 9| 9| 9| 3| 9| 8| 9| 9| 5| 9| 9| 0| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Hemorrhage | 2 1 |
Infiltration Cellular, Histiocyte | 2 1 |
Inflammation, Chronic Active | |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | 1 1 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + M + + + + + + + + + + + + +|
Inflammation, Acute | |
Glands, Inflammation, Acute | 1 |
Respiratory Epithelium, Necrosis | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Inflammation, Acute, Necrotizing | |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1|
Metaplasia, Osseous | |
Mineralization | |
Proximal Convoluted Renal Tubule, | |
Regeneration | |
Renal Tubule, Mineralization | 1 |
Renal Tubule, Pigmentation | 2 1 1 1 1 1 2 1 2 1 1 1 1 2 2 1 1|
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 1 2 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 4| 6| 6| 2| 7| 4| 7| 6| 5|
DAY ON TEST | 2| 6| 2| 2| 9| 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 6| 1| 4| 2| 5| 2| 3| 1|
| 9| 0| 9| 6| 6| 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 0| 5| 8| 8| 9| 8| 4| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.0% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Gallbladder | + + + + + + M + + + + + + + + + M + + M + + + + M|
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 2 1 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + M + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + M + + + + + + + + + + + + A + + + + + + +|
Mesothelium, Hyperplasia | |
Serosa, Fibrosis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Pigmentation | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Peyer's Patch, Hyperplasia | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Focal | |
Basophilic Focus | 1 |
Clear Cell Focus | 1 |
Eosinophilic Focus | |
Fatty Change | 1 4 1 |
Hematopoietic Cell Proliferation | 2 1 2 1 1 1 1 |
Infarct | |
Inflammation, Acute | 1 |
Inflammation, Chronic Active | 1 2 1 2 1 1 1 1 1 1 1 2 |
Karyomegaly | |
Necrosis, Coagulative | 1 1 1 1 1 2 1 1 1|
Pigmentation | 2 1 2 2 2 1 1 1 2 1 1 2 1 1 1 2 2 1 2 2 1 2 2 1|
Thrombosis | |
Bile Duct, Hyperplasia | 2 |
Centrilobular, Cytoplasmic Alteration| 2 3 3 |
Hepatocyte, Centrilobular, | |
Hypertrophy | 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Abscess | 4 |
Fibrosis | |
Inflammation, Chronic Active | 3 3 2 2 |
Mineralization | |
Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + M + +|
Atrophy | |
Cytoplasmic Alteration | 2 2 |
Inflammation, Chronic Active | 1 2 3 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 4| 6| 6| 2| 7| 4| 7| 6| 5|
DAY ON TEST | 2| 6| 2| 2| 9| 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 6| 1| 4| 2| 5| 2| 3| 1|
| 9| 0| 9| 6| 6| 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 0| 5| 8| 8| 9| 8| 4| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.0% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Vacuolization Cytoplasmic | 2 2 1|
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Parotid Gland, Mineralization | |
Sublingual Gland, Submandibular | |
Gland, Inflammation, Chronic | |
Submandibular Gland, Atrophy | |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 2 2 1 1 1 2 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 |
Hyperkeratosis | 1 3 3 2 |
Hyperplasia, Basal Cell | 1 1 |
Inflammation, Acute | |
Inflammation, Chronic Active | 1 1 1 1 2 3 |
Inflammation, Chronic Active, | |
Necrotizing | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + M + +|
Edema | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 2 1|
Mineralization | 1 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Vacuolization Cytoplasmic | |
Capsule, Inflammation, Chronic Active| 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | 1 |
Inflammation, Chronic | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + + + M M + + + + + M + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M M + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 4| 6| 6| 2| 7| 4| 7| 6| 5|
DAY ON TEST | 2| 6| 2| 2| 9| 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 6| 1| 4| 2| 5| 2| 3| 1|
| 9| 0| 9| 6| 6| 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 0| 5| 8| 8| 9| 8| 4| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.0% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 2 1 1 1 2 1 1 1 1 1 1 |
Serosa, Hyperplasia | 1 |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + M + + + |
Abscess | |
Inflammation, Chronic Active | 2 2 2 1 |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + M + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 1 2 1 1 1 2 1 1 1 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + M + + + + + + + + + + + + + + + + + M + |
Atrophy | 3 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic Active | 1 1 |
Seminiferous Tubule, Atrophy | 1 |
Seminiferous Tubule, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Sternal, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | + + + + |
Hyperplasia, Lymphoid | |
Lumbar, Hyperplasia, Plasma Cell | 4 |
Mediastinal, Inflammation, Chronic | |
Active | |
Pancreatic, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M I M M M M M + M M + + + + + + + + M +|
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 4| 6| 6| 2| 7| 4| 7| 6| 5|
DAY ON TEST | 2| 6| 2| 2| 9| 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 6| 1| 4| 2| 5| 2| 3| 1|
| 9| 0| 9| 6| 6| 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 0| 5| 8| 8| 9| 8| 4| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.0% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
Necrosis, Coagulative | 1 |
Pigmentation | 1 1 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
Angiectasis | 1 3 1 3 2 2 1 2 3 2 |
Depletion Lymphoid | 3 |
Hemorrhage | 4 2 |
Hyperplasia, Lymphoid | 3 2 |
Hyperplasia | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 2 2 2 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + I + + + + + + + +|
Congestion | 2 |
Depletion Lymphoid | 2 4 |
Fibrosis | |
Hematopoietic Cell Proliferation | 4 3 2 1 4 2 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Thymus | + + + + M + M M + + M M + M M + M + + + + + M M +|
Cyst | 1 1 1 1 |
Depletion Lymphoid | 3 3 4 |
Necrosis, Coagulative | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M M M M M M M M M M M M M + M M M M + M M M|
__________________________________________________________________________|
Skin | + + + + M + + + + + + + + + + + + + + + M + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 |
Subcutaneous Tissue, Abscess | 2 |
Subcutaneous Tissue, Fibrosis | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | 4 3 2 4 4 4 |
__________________________________________________________________________|
Skeletal Muscle | + |
Intercostal, Inflammation, Chronic | |
Active | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 6| 5| 7| 4| 6| 6| 2| 7| 4| 7| 6| 5|
DAY ON TEST | 2| 6| 2| 2| 9| 2| 2| 2| 2| 2| 1| 2| 0| 6| 3| 2| 6| 6| 1| 4| 2| 5| 2| 3| 1|
| 9| 0| 9| 6| 6| 9| 9| 9| 9| 3| 7| 9| 9| 2| 5| 9| 0| 5| 8| 8| 9| 8| 4| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.0% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 1 1 1 1 1 |
Infiltration Cellular, Histiocyte | 1 1 |
Inflammation, Chronic Active | |
Pigmentation | 1|
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Acute | 1 1 1 2 2 1|
Glands, Inflammation, Acute | 1 |
Respiratory Epithelium, Necrosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Acute, Necrotizing | 3 |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 1 2 2 3 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1|
Metaplasia, Osseous | 1 |
Mineralization | 1 |
Proximal Convoluted Renal Tubule, | |
Regeneration | 1 |
Renal Tubule, Mineralization | |
Renal Tubule, Pigmentation | 1 2 2 1 1 2 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
Renal Tubule, Regeneration | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 6| 4| 4| 2| 1| 7| 7| 4| 7| 6| | |
DAY ON TEST | 8| 5| 5| 4| 0| 2| 2| 5| 2| 1| | |
| 9| 8| 8| 9| 9| 9| 9| 8| 2| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + M | 51 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | | 8 1.3|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M + + + + + | 56 |
Mesothelium, Hyperplasia | | 1 1.0|
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + | 58 |
Epithelium, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + M + + + + + | 57 |
Inflammation, Chronic Active | | 1 2.0|
Peyer's Patch, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus, Focal | | 1 2.0|
Basophilic Focus | | 4 1.0|
Clear Cell Focus | | 2 1.0|
Eosinophilic Focus | | 1 1.0|
Fatty Change | | 7 1.6|
Hematopoietic Cell Proliferation | 3 | 10 1.4|
Infarct | | 1 4.0|
Inflammation, Acute | | 3 1.0|
Inflammation, Chronic Active | 1 1 1 1 2 1 | 27 1.3|
Karyomegaly | | 1 3.0|
Necrosis, Coagulative | 1 1 1 1 1 1 | 28 1.1|
Pigmentation | 2 1 2 1 1 1 1 1 2 | 57 1.4|
Thrombosis | | 1 1.0|
Bile Duct, Hyperplasia | | 1 2.0|
Centrilobular, Cytoplasmic Alteration| 3 3 3 | 8 2.9|
Hepatocyte, Centrilobular, | | |
Hypertrophy | 2 2 | 13 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 9 |
Abscess | | 1 4.0|
Fibrosis | 1 | 1 1.0|
Inflammation, Chronic Active | 3 | 5 2.6|
Mineralization | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 6| 4| 4| 2| 1| 7| 7| 4| 7| 6| | |
DAY ON TEST | 8| 5| 5| 4| 0| 2| 2| 5| 2| 1| | |
| 9| 8| 8| 9| 9| 9| 9| 8| 2| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Necrosis, Coagulative | 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Atrophy | | 1 1.0|
Cytoplasmic Alteration | | 2 2.0|
Inflammation, Chronic Active | | 8 1.4|
Vacuolization Cytoplasmic | | 4 1.8|
Artery, Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Duct, Parotid Gland, Mineralization | | 1 1.0|
Sublingual Gland, Submandibular | | |
Gland, Inflammation, Chronic | | 1 1.0|
Submandibular Gland, Atrophy | | 1 1.0|
Submandibular Gland, Inflammation, | | |
Chronic | 1 1 1 1 1 2 1 | 40 1.2|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Acanthosis | | 7 2.0|
Hyperkeratosis | | 9 1.9|
Hyperplasia, Basal Cell | | 3 1.3|
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic Active | 2 | 14 1.5|
Inflammation, Chronic Active, | | |
Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Edema | | 1 1.0|
Inflammation, Chronic | 1 | 2 1.0|
Inflammation, Chronic Active | 1 | 23 1.1|
Mineralization | 1 | 3 1.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + + | 7 |
Dysplasia | 1 1 | 6 1.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | | 1 1.0|
Inflammation, Chronic | 1 1 | 5 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 6| 4| 4| 2| 1| 7| 7| 4| 7| 6| | |
DAY ON TEST | 8| 5| 5| 4| 0| 2| 2| 5| 2| 1| | |
| 9| 8| 8| 9| 9| 9| 9| 8| 2| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Vacuolization Cytoplasmic | 2 | 1 2.0|
Capsule, Inflammation, Chronic Active| | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 49 |
Hyperplasia | | 1 1.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 56 |
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Hyperplasia | 1 1 | 6 1.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + M + | 59 |
Inflammation, Chronic | 1 | 1 1.0|
Follicle, Cyst | 1 | 1 1.0|
Follicular Cell, Hyperplasia | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 1 1 3 1 | 26 1.2|
Serosa, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Penis | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 13 |
Abscess | | 2 3.5|
Inflammation, Chronic Active | 4 2 2 | 11 2.0|
Duct, Dilatation | | 2 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 57 |
Inflammation, Chronic | 1 | 2 1.5|
Inflammation, Chronic Active | 1 2 | 20 1.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 55 |
Atrophy | | 1 3.0|
Inflammation, Chronic Active | | 13 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Atrophy | 1 | 2 1.0|
Inflammation, Chronic Active | | 2 1.0|
Seminiferous Tubule, Atrophy | 1 | 4 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 6| 4| 4| 2| 1| 7| 7| 4| 7| 6| | |
DAY ON TEST | 8| 5| 5| 4| 0| 2| 2| 5| 2| 1| | |
| 9| 8| 8| 9| 9| 9| 9| 8| 2| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Seminiferous Tubule, Mineralization | | 3 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Myeloid Cell, Sternal, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 11 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Lumbar, Hyperplasia, Plasma Cell | | 2 3.0|
Mediastinal, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
Pancreatic, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + M M + M + + + | 36 |
Depletion Lymphoid | | 1 4.0|
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 | 8 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Necrosis, Coagulative | | 1 1.0|
Pigmentation | 1 | 9 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + M + M + + + | 55 |
Angiectasis | 4 1 2 | 21 2.0|
Depletion Lymphoid | | 1 3.0|
Hemorrhage | 1 1 | 4 2.0|
Hyperplasia, Lymphoid | 2 | 4 2.5|
Hyperplasia | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 | 22 1.0|
Inflammation, Chronic Active | 2 | 4 2.0|
Pigmentation | 1 | 20 1.0|
__________________________________________________________________________|____________|
Spleen | + M + + + + + + + + | 58 |
Congestion | | 1 2.0|
Depletion Lymphoid | | 3 2.3|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 2 3 | 12 2.6|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + M + | 41 |
Cyst | 1 1 1 | 12 1.0|
Depletion Lymphoid | | 6 3.3|
Necrosis, Coagulative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 6| 4| 4| 2| 1| 7| 7| 4| 7| 6| | |
DAY ON TEST | 8| 5| 5| 4| 0| 2| 2| 5| 2| 1| | |
| 9| 8| 8| 9| 9| 9| 9| 8| 2| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M M M M + M M | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 58 |
Inflammation, Chronic Active | 4 2 | 13 1.4|
Subcutaneous Tissue, Abscess | | 1 2.0|
Subcutaneous Tissue, Fibrosis | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
Joint, Tarsal, Hyperostosis | 4 2 | 12 3.4|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Intercostal, Inflammation, Chronic | | |
Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | | 1 2.0|
Thalamus, Mineralization | 1 1 1 | 19 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 1.0|
Hemorrhage | 1 2 | 10 1.2|
Infiltration Cellular, Histiocyte | 1 2 | 6 1.3|
Inflammation, Chronic Active | 2 | 1 2.0|
Pigmentation | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 4 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 58 |
Inflammation, Acute | | 6 1.3|
Glands, Inflammation, Acute | | 2 1.0|
Respiratory Epithelium, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Inflammation, Acute | | 3 1.3|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05061-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 09:33:30
__________________________________________________________________________________________________________________________________
| 6| 4| 4| 2| 1| 7| 7| 4| 7| 6| | |
DAY ON TEST | 8| 5| 5| 4| 0| 2| 2| 5| 2| 1| | |
| 9| 8| 8| 9| 9| 9| 9| 8| 2| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.0% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 1 2.0|
Inflammation, Acute, Necrotizing | | 1 3.0|
Inflammation, Chronic | 1 2 1 | 8 1.1|
Inflammation, Chronic Active | 1 1 1 1 2 1 | 47 1.2|
Metaplasia, Osseous | | 1 1.0|
Mineralization | | 1 1.0|
Proximal Convoluted Renal Tubule, | | |
Regeneration | | 1 1.0|
Renal Tubule, Mineralization | | 1 1.0|
Renal Tubule, Pigmentation | 2 1 2 1 | 43 1.3|
Renal Tubule, Regeneration | 1 | 4 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 5 1.0|
Inflammation, Chronic Active | 1 1 1 | 34 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
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