TR 383 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason 1-AMINO-2,4-DIBROMOANTHRAQUINONE DATE: 05/19/95
EXPERIMENT: 05061 TEST: 02 TIME: 17:22:49
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES9561903 ROUTE: DOSED FEED NTP C#: 55458
PATHOLOGIST: R. FLEISCHMAN CAS: 81-49-2
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason 1-AMINO-2,4-DIBROMOANTHRAQUINONE DATE: 05/19/95
EXPERIMENT: 05061 TEST: 02 TIME: 17:22:49
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES9561903 ROUTE: DOSED FEED NTP C#: 55458
PATHOLOGIST: R. FLEISCHMAN CAS: 81-49-2
1-AMINO-2,4-DIBROMOANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATED 71UM |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 10 CENSORED DEATHS 10 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 292 393 445 480 521 621 705 705 723 723 |
| CENSORED DEATHS |
| 458 460 460 460 460 460 460 460 460 460 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0% 71 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 28 CENSORED DEATHS 10 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 152 414 451 464 501 505 550 572 578 582 |
| 583 611 612 613 618 633 633 642 647 648 |
| 654 673 673 689 706 709 715 717 |
| CENSORED DEATHS |
| 457 458 458 458 458 458 458 460 460 460 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.0% 71 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 27 CENSORED DEATHS 10 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 109 136 248 249 484 512 517 523 535 593 |
| 606 613 618 618 621 633 645 648 662 665 |
| 689 689 696 709 722 724 726 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 460 460 460 |
| |
==================================================================================
1-AMINO-2,4-DIBROMOANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATED | 100.0 100.0 100.0 98.3 96.7 93.0 91.0 91.0 88.9 80.9 |
|71UM | |
| | |
|1.0% 71 | 100.0 98.3 98.3 98.3 96.7 93.0 88.9 78.8 58.6 44.5 |
| | |
| | |
|2.0% 71 | 100.0 96.7 93.3 93.3 93.3 91.3 83.2 81.2 60.9 46.7 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATED 1.0% 71 2.0% 71 |
| 71UM |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 80.9% 44.5% 46.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.001 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 560.8 590.9 562.6 |
|NATURAL DEATHS (C) | (49.4) (22.3) (33.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 656.1 619.5 609.1 |
|(STANDARD ERROR) | (16.0) (16.2) (20.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
1-AMINO-2,4-DIBROMOANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATED 71UF |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 10 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 76 478 592 610 628 653 685 701 701 706 |
| 708 |
| CENSORED DEATHS |
| 455 455 455 455 455 455 455 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0% 71 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 16 CENSORED DEATHS 10 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 202 372 442 503 555 587 652 657 671 679 |
| 706 713 713 713 716 727 |
| CENSORED DEATHS |
| 455 455 455 455 455 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.0% 71 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 10 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 501 538 553 562 568 596 623 623 631 662 |
| 664 680 697 713 718 723 724 |
| CENSORED DEATHS |
| 455 455 455 457 457 457 457 457 457 457 |
| |
==================================================================================
1-AMINO-2,4-DIBROMOANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATED | 98.3 98.3 98.3 98.3 98.3 96.3 96.3 94.3 88.3 78.3 |
|71UF | |
| | |
|1.0% 71 | 100.0 100.0 98.3 98.3 96.7 95.0 93.0 88.9 84.9 68.7 |
| | |
| | |
|2.0% 71 | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 88.0 78.0 66.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATED 1.0% 71 2.0% 71 |
| 71UF |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 78.3% 68.7% 66.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.234 P=0.381 P=0.259 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 594.4 600.5 633.9 |
|NATURAL DEATHS (C) | (55.9) (37.8) (17.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 658.8 649.2 656.6 |
|(STANDARD ERROR) | (16.8) (16.6) (13.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
1-AMINO-2,4-DIBROMOANTHRAQUINONE
KAPLAN-MEIER SURVIVAL CURVES
UNTREATED 71UM = 1
1.0% 71 = 2
2.0% 71 = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
| 3 3 2 3 1 1 2 1 2
| 1 2 2 1
| 3 2 13 2 3 1
P 90 + 22 1 2 1 1
E | 3 3 2 2
R | 3 3 22 1 1
C | 3 22 3
E 80 + 2 3 32 1 1
N | 33
T |
| 22
S 70 + 2 2 3
U | 22
R | 22 3
V |
I 60 + 22 3 3
V | 2 2 33
A | 2 23 3
L | 2 23 3
50 + 22
| 223 3
| 2 2
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.
1-AMINO-2,4-DIBROMOANTHRAQUINONE
KAPLAN-MEIER SURVIVAL CURVES
UNTREATED 71UF = 1
1.0% 71 = 2
2.0% 71 = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
| 1 2 2 1
| 3 3
| 2 2 1 3 3 1
95 + 2 2
| 3 3 1 1
P | 2 233 1 1
E | 2 2
R 90 + 3 3 1 1
C | 2 1 1
E | 3 3
N | 1 1
T 85 + 2 2
| 3 3
S | 3 322
U | 2 2
R 80 + 11
V | 21 1
I | 3 3
V | 3 3
A 75 +
L | 3 3
| 22
| 22
70 + 33
| 2 2
|
| 3 3
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 6 obs hidden.
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