TR 383 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
1-AMINO 2,4-DIBROMOANTHRAQUINONE
NTP Experiment-Test: 05061-01 Report: PEIRPT03
Study Type: CHRONIC Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
Facility: TSI Mason Research
Chemical CAS #: 81-49-2
Lock Date: 03/25/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71UF 71LF 71MLF 71MHF 71HF FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 50 70 70 30 10
Scheduled Sacrifice 20 10 10 20 21 9
Early Deaths
Moribund 8 5 15 29 5 1
Dead 4 3 7 8 3
Survivors
Terminal Sacrifice 37 32 38 12
Dead 1
Wrong Sex 1 1
Animals Examined Microscopically 70 50 70 69 28 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (70) (50) (67) (58) (28) (10)
Autolysis 1 (1%)
Intestine Large, Colon (69) (50) (69) (57) (28) (10)
Autolysis 3 (4%) 5 (7%) 3 (5%)
Parasite Metazoan 17 (25%) 13 (26%) 9 (13%) 7 (12%) 1 (10%)
Lymphoid Tissue, Hemorrhage 1 (2%)
Intestine Large, Rectum (69) (50) (70) (67) (27) (10)
Atypia Cellular 1 (2%) 6 (9%)
Autolysis 4 (6%) 6 (9%) 1 (1%)
Diverticulum 1 (1%)
Fibrosis 1 (2%)
Inflammation, Acute, Necrotizing 3 (4%)
Parasite Metazoan 12 (17%) 4 (8%) 9 (13%) 9 (13%) 1 (10%)
Ulcer 1 (1%)
Epithelium, Hyperplasia 3 (4%)
Intestine Large, Cecum (70) (50) (70) (57) (28) (10)
Autolysis 4 (6%) 1 (2%) 6 (9%) 4 (7%)
Hemorrhage 1 (2%)
Mineralization 1 (1%)
Parasite Metazoan 6 (9%) 7 (14%) 5 (7%) 2 (4%) 2 (20%)
Intestine Small, Duodenum (70) (50) (69) (56) (28) (10)
Autolysis 2 (3%) 5 (7%) 1 (2%)
Intestine Small, Jejunum (68) (50) (69) (56) (27) (10)
Autolysis 3 (4%) 1 (2%) 8 (12%) 3 (5%)
Intestine Small, Ileum (69) (49) (69) (54) (28) (10)
Autolysis 3 (4%) 1 (2%) 8 (12%) 4 (7%)
Parasite Metazoan 1 (2%)
Ulcer 1 (1%)
Liver (70) (50) (70) (68) (28) (10)
Abscess 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71UF 71LF 71MLF 71MHF 71HF FEMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Angiectasis 1 (1%) 1 (2%) 2 (7%)
Autolysis 4 (6%)
Basophilic Focus 48 (69%) 15 (30%) 22 (31%) 26 (38%) 16 (57%) 6 (60%)
Clear Cell Focus 3 (4%) 28 (56%) 39 (56%) 23 (34%) 14 (50%) 5 (50%)
Cyst 1 (10%)
Cytomegaly 2 (7%) 1 (10%)
Cytoplasmic Alteration 1 (10%)
Degeneration 3 (4%)
Developmental Malformation 1 (1%)
Eosinophilic Focus 9 (13%) 23 (46%) 12 (17%) 1 (1%) 3 (11%) 2 (20%)
Fatty Change 8 (11%) 4 (6%) 14 (21%) 17 (61%)
Hematopoietic Cell Proliferation 10 (14%) 2 (3%) 1 (4%)
Hemorrhage 1 (1%)
Hepatodiaphragmatic Nodule 10 (14%) 4 (8%) 1 (1%) 1 (1%)
Hepatodiaphragmatic Nodule, Multiple 1 (1%)
Hyperplasia, Focal 1 (2%)
Infarct 1 (1%)
Inflammation, Chronic, Granulomatous 6 (9%) 6 (9%) 1 (4%) 2 (20%)
Inflammation, Chronic Active 24 (34%) 16 (32%) 23 (33%) 7 (10%) 1 (4%)
Mixed Cell Focus 1 (1%) 11 (22%) 5 (7%) 4 (6%) 3 (11%) 2 (20%)
Necrosis, Coagulative 4 (6%) 4 (8%) 11 (16%) 17 (25%) 12 (43%)
Pigmentation 2 (3%) 21 (42%) 57 (81%) 61 (90%) 27 (96%) 10 (100%)
Thrombosis 1 (1%) 1 (1%)
Bile Duct, Hyperplasia 41 (59%) 10 (20%) 65 (93%) 55 (81%) 27 (96%) 10 (100%)
Centrilobular, Hemorrhage 1 (1%)
Centrilobular, Necrosis, Coagulative 1 (1%)
Periportal, Inflammation, Chronic 10 (14%) 10 (15%) 11 (39%) 9 (90%)
Periportal, Inflammation, Chronic Active 31 (44%) 12 (24%) 64 (91%) 47 (69%) 17 (61%) 1 (10%)
Mesentery (4) (6) (1) (5) (1)
Fibrosis 2 (50%) 5 (83%) 1 (100%) 1 (20%)
Inflammation, Chronic 1 (20%)
Inflammation, Chronic, Granulomatous 1 (100%)
Inflammation, Chronic Active 3 (75%) 3 (50%) 1 (100%) 1 (20%)
Necrosis, Coagulative 2 (50%) 5 (83%) 1 (100%) 1 (100%)
Pigmentation 1 (20%)
Polyarteritis 1 (17%) 1 (20%)
Pancreas (70) (50) (70) (58) (28) (10)
Atrophy 22 (31%) 19 (38%) 16 (23%) 15 (26%) 5 (18%) 3 (30%)
Autolysis 1 (1%) 1 (1%) 1 (2%)
Cytoplasmic Alteration 1 (2%) 2 (3%) 1 (2%)
Ectopic Liver 2 (3%)
Ectopic Tissue 2 (3%) 1 (2%) 1 (4%)
Infiltration Cellular, Mononuclear Cell 3 (4%) 7 (14%) 1 (1%) 1 (2%) 4 (14%)
Infiltration Cellular, Mixed Cell 1 (1%)
Inflammation, Chronic 9 (13%) 1 (2%) 6 (21%) 6 (60%)
Inflammation, Chronic Active 29 (41%) 24 (48%) 30 (43%) 22 (38%) 2 (7%)
Polyarteritis 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71UF 71LF 71MLF 71MHF 71HF FEMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Vacuolization Cytoplasmic 5 (7%) 12 (17%) 3 (5%)
Acinus, Hyperplasia 1 (1%) 1 (2%)
Duct, Hyperplasia 1 (1%)
Pharynx (1) (1)
Hemorrhage 1 (100%)
Salivary Glands (70) (50) (70) (58) (28) (10)
Infiltration Cellular, Mononuclear Cell 2 (3%)
Infiltration Cellular, Lymphocyte 1 (1%)
Duct, Submandibular Gland, Dilatation 1 (4%)
Parotid Gland, Atrophy 1 (4%)
Parotid Gland, Inflammation, Chronic 2 (7%)
Parotid Gland, Inflammation, Chronic Active 2 (3%) 1 (2%) 2 (7%)
Sublingual Gland, Inflammation, Chronic
Active 1 (1%)
Submandibular Gland, Atrophy 1 (4%)
Submandibular Gland, Inflammation, Chronic 1 (4%)
Submandibular Gland, Inflammation, Chronic
Active 1 (1%) 1 (1%) 5 (18%)
Submandibular Gland, Metaplasia, Squamous 2 (7%)
Submandibular Gland, Pigmentation 1 (4%)
Stomach, Forestomach (69) (50) (70) (67) (28) (10)
Acanthosis 1 (4%)
Autolysis 1 (1%)
Cyst Epithelial Inclusion 1 (1%)
Erosion 2 (3%) 3 (4%) 1 (4%)
Hyperkeratosis 2 (3%) 7 (14%) 23 (33%) 28 (42%) 1 (4%)
Hyperplasia, Basal Cell 2 (3%) 7 (14%) 35 (50%) 29 (43%) 6 (21%)
Hyperplasia, Squamous 2 (3%) 7 (14%) 26 (37%) 33 (49%) 2 (7%)
Inflammation, Chronic 1 (1%)
Inflammation, Chronic Active 1 (2%) 13 (19%) 10 (15%)
Ulcer 1 (1%) 2 (4%) 7 (10%) 17 (25%) 1 (4%)
Muscularis, Mineralization 1 (4%)
Stomach, Glandular (70) (50) (70) (68) (28) (10)
Autolysis 2 (3%) 3 (4%) 1 (1%)
Fibrosis 1 (1%)
Inflammation, Chronic 1 (4%)
Inflammation, Chronic Active 3 (4%) 1 (2%) 6 (9%) 6 (9%)
Mineralization 1 (10%)
Necrosis, Coagulative 1 (1%) 1 (1%)
Ulcer 1 (1%)
Artery, Mineralization 1 (4%)
Muscularis, Mineralization 2 (3%) 2 (7%)
Tongue (1)
Foreign Body 1 (100%)
Inflammation, Chronic 1 (100%)
Tooth (1) (1) (1)
Cyst 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71UF 71LF 71MLF 71MHF 71HF FEMALE
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Inflammation, Chronic 1 (100%)
Heart (70) (50) (70) (59) (28) (10)
Cardiomyopathy 63 (90%) 46 (92%) 60 (86%) 43 (73%) 18 (64%) 10 (100%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (67) (50) (69) (58) (27) (10)
Angiectasis 30 (45%) 32 (64%) 41 (59%) 26 (45%) 3 (11%) 2 (20%)
Autolysis 1 (1%) 3 (5%)
Hyperplasia 3 (4%) 4 (8%) 4 (6%) 1 (2%) 1 (10%)
Hypertrophy 1 (1%)
Necrosis, Coagulative 1 (1%)
Thrombosis, Multiple 1 (1%)
Vacuolization Cytoplasmic 17 (25%) 16 (32%) 35 (51%) 20 (34%) 1 (4%)
Capsule, Fibrosis 1 (1%)
Capsule, Hyperplasia 1 (1%)
Capsule, Inflammation, Chronic 1 (1%)
Zona Reticularis, Hyperplasia 1 (2%)
Adrenal Medulla (67) (50) (69) (58) (27) (10)
Autolysis 1 (1%) 1 (2%)
Hyperplasia 11 (16%) 5 (10%) 11 (16%) 14 (24%) 2 (7%) 1 (10%)
Islets, Pancreatic (50) (40) (60) (47) (7) (1)
Autolysis 1 (2%)
Parathyroid Gland (63) (47) (67) (48) (25) (10)
Hyperplasia 3 (6%) 1 (1%) 1 (10%)
Pituitary Gland (70) (49) (70) (57) (28) (10)
Thrombosis 1 (1%)
Pars Distalis, Angiectasis 3 (6%) 1 (1%) 1 (4%) 5 (50%)
Pars Distalis, Autolysis 2 (3%) 1 (2%)
Pars Distalis, Cyst 24 (34%) 21 (43%) 23 (33%) 18 (32%) 11 (39%) 6 (60%)
Pars Distalis, Cyst, Multiple 3 (5%)
Pars Distalis, Hemorrhage 1 (1%)
Pars Distalis, Hyperplasia 14 (20%) 10 (20%) 15 (21%) 8 (14%) 2 (7%)
Pars Distalis, Necrosis, Coagulative 1 (2%)
Pars Distalis, Pars Intermedia, Cyst 2 (3%)
Pars Intermedia, Cyst 4 (6%) 3 (4%) 4 (14%) 1 (10%)
Rathke's Cleft, Cyst 1 (2%)
Thyroid Gland (70) (50) (70) (59) (28) (10)
Autolysis 2 (3%) 1 (1%) 4 (7%)
Infiltration Cellular, Mononuclear Cell 1 (1%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (1%)
Ultimobranchial Cyst 1 (1%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71UF 71LF 71MLF 71MHF 71HF FEMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
C-Cell, Hyperplasia 11 (16%) 2 (4%) 3 (4%) 2 (3%)
Follicle, Cyst 1 (1%)
Follicular Cell, Hyperplasia 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (1) (1) (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (65) (46) (68) (58) (27) (10)
Abscess 2 (3%) 3 (4%) 1 (2%)
Cyst 1 (2%) 1 (2%) 1 (4%)
Hyperplasia 1 (2%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Inflammation, Chronic 10 (15%) 3 (5%) 4 (15%) 6 (60%)
Inflammation, Chronic Active 37 (57%) 21 (46%) 51 (75%) 31 (53%) 10 (37%) 1 (10%)
Duct, Metaplasia, Squamous 1 (2%)
Ovary (70) (50) (70) (61) (28) (10)
Congestion 1 (2%)
Cyst 11 (16%) 3 (6%) 5 (7%) 6 (10%)
Pigmentation 1 (2%)
Periovarian Tissue, Cyst 4 (8%) 3 (4%) 4 (7%) 4 (14%)
Uterus (70) (50) (70) (60) (28) (10)
Abscess 6 (12%) 8 (11%)
Autolysis 1 (2%)
Cyst 1 (1%) 5 (10%) 3 (5%)
Decidual Reaction 1 (1%)
Fibrosis 3 (4%) 1 (1%) 1 (2%)
Hydrometra 8 (11%) 6 (12%) 9 (13%) 12 (20%) 6 (21%) 2 (20%)
Inflammation, Acute 1 (1%)
Inflammation, Chronic Active 1 (2%) 1 (4%)
Endometrium, Hyperplasia 5 (7%) 9 (18%) 2 (3%) 1 (2%) 1 (4%) 1 (10%)
Submucosa, Hyperplasia 1 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (50) (70) (59) (28) (10)
Autolysis 1 (1%)
Myelofibrosis 1 (2%)
Lymph Node (7) (11) (28) (24) (9) (1)
Pigmentation 1 (4%)
Iliac, Infiltration Cellular, Histiocyte 1 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71UF 71LF 71MLF 71MHF 71HF FEMALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lumbar, Hemorrhage 1 (4%)
Lumbar, Infiltration Cellular, Histiocyte 2 (8%)
Lumbar, Pigmentation 1 (4%)
Mediastinal, Hemorrhage 4 (57%) 1 (9%) 3 (11%) 3 (13%) 1 (100%)
Mediastinal, Hyperplasia 1 (14%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (14%) 1 (9%) 2 (7%) 3 (13%)
Mediastinal, Pigmentation 1 (14%) 1 (9%) 2 (7%) 2 (8%) 3 (33%)
Pancreatic, Depletion Lymphoid 1 (9%)
Pancreatic, Hemorrhage 2 (18%) 1 (4%) 3 (13%)
Pancreatic, Hyperplasia 2 (29%) 5 (18%) 1 (4%)
Pancreatic, Infiltration Cellular, Histiocyte 3 (43%) 8 (73%) 21 (75%) 11 (46%) 8 (89%) 1 (100%)
Pancreatic, Pigmentation 3 (27%) 1 (4%) 4 (17%) 7 (78%) 1 (100%)
Renal, Hemorrhage 1 (9%) 1 (4%)
Renal, Infiltration Cellular, Histiocyte 1 (9%) 1 (4%)
Renal, Pigmentation 1 (9%) 1 (4%)
Lymph Node, Mandibular (66) (49) (66) (53) (27) (9)
Autolysis 1 (2%)
Depletion Lymphoid 1 (2%)
Hemorrhage 8 (12%) 3 (6%) 5 (8%) 4 (8%) 3 (11%) 3 (33%)
Hyperplasia 1 (2%) 2 (3%) 1 (2%) 1 (4%)
Infiltration Cellular, Histiocyte 1 (2%) 2 (4%) 1 (2%) 9 (17%) 7 (26%)
Inflammation, Chronic Active 1 (2%)
Pigmentation 1 (2%)
Lymph Node, Mesenteric (70) (50) (69) (60) (28) (9)
Autolysis 1 (1%) 2 (3%)
Depletion Lymphoid 2 (3%) 1 (2%) 2 (3%) 8 (13%) 1 (4%)
Hemorrhage 4 (8%) 4 (6%) 3 (5%) 5 (18%) 2 (22%)
Infiltration Cellular, Histiocyte 69 (99%) 49 (98%) 67 (97%) 59 (98%) 28 (100%) 9 (100%)
Pigmentation 10 (14%) 7 (14%) 8 (12%) 4 (7%) 12 (43%) 8 (89%)
Spleen (70) (50) (70) (58) (28) (10)
Autolysis 1 (2%)
Congestion 1 (2%) 1 (4%)
Depletion Lymphoid 8 (11%) 1 (2%) 3 (4%) 7 (12%)
Fibrosis 1 (2%) 1 (1%) 1 (2%) 1 (4%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 1 (1%)
Infiltration Cellular, Histiocyte 1 (1%)
Thymus (62) (41) (61) (55) (22) (10)
Congestion 1 (2%)
Cyst 1 (2%) 1 (2%) 1 (2%)
Depletion Lymphoid 1 (2%) 4 (7%) 6 (27%) 1 (10%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%) 2 (9%) 1 (10%)
Pigmentation 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71UF 71LF 71MLF 71MHF 71HF FEMALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (65) (38) (54) (47) (19) (7)
Galactocele 1 (2%)
Hyperplasia 47 (72%) 29 (76%) 41 (76%) 26 (55%) 5 (26%) 4 (57%)
Inflammation, Chronic Active 1 (2%)
Skin (70) (49) (70) (60) (28) (10)
Abscess 1 (1%) 1 (2%)
Cyst Epithelial Inclusion 2 (3%)
Foreign Body 1 (1%)
Inflammation, Chronic Active 2 (3%) 6 (9%) 2 (3%)
Foot, Acanthosis 1 (1%)
Foot, Hyperkeratosis 1 (1%)
Foot, Inflammation, Chronic Active 1 (2%) 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (50) (70) (59) (28) (10)
Osteopetrosis 1 (1%)
Cranium, Osteopetrosis 1 (2%)
Femur, Osteopetrosis 1 (2%)
Sternum, Osteopetrosis 1 (1%) 3 (5%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (50) (70) (59) (28) (10)
Hydrocephalus 1 (1%) 2 (4%)
Infarct 1 (1%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (50) (70) (64) (28) (10)
Autolysis 1 (1%)
Congestion 1 (10%)
Fibrosis 2 (3%)
Hemorrhage 1 (1%) 1 (1%)
Infiltration Cellular, Histiocyte 38 (54%) 33 (66%) 53 (76%) 43 (67%) 17 (61%) 7 (70%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 4 (6%) 3 (4%) 2 (3%) 1 (4%)
Polyarteritis 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (1%) 1 (2%)
Alveolus, Mineralization 1 (1%)
Artery, Mineralization 31 (44%) 9 (18%) 23 (33%) 18 (28%) 12 (43%) 5 (50%)
Bronchiole, Epithelium, Hyperplasia 1 (1%)
Mediastinum, Polyarteritis 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71UF 71LF 71MLF 71MHF 71HF FEMALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nose (70) (50) (70) (59) (28) (10)
Autolysis 1 (2%)
Foreign Body 1 (1%) 4 (6%)
Inflammation, Chronic Active 9 (13%) 8 (16%) 13 (19%) 12 (20%) 2 (7%)
Metaplasia, Squamous 1 (1%) 4 (8%) 4 (6%) 2 (3%)
Arteriole, Thrombosis 1 (2%)
Submucosa, Inflammation, Chronic 1 (1%)
Trachea (70) (50) (70) (59) (28) (10)
Autolysis 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (8) (3)
External Ear, Inflammation, Acute 2 (25%)
Internal Ear, Inflammation, Acute 1 (13%)
Eye (13) (7) (7) (7) (2)
Phthisis Bulbi 1 (14%) 1 (14%)
Synechia 1 (8%) 1 (14%)
Anterior Chamber, Inflammation, Acute 1 (50%)
Cornea, Inflammation, Acute 1 (14%)
Lens, Cataract 1 (8%) 1 (14%)
Posterior Chamber, Inflammation, Acute 1 (50%)
Retina, Degeneration 1 (8%) 3 (43%) 1 (14%) 1 (50%)
Harderian Gland (1)
Hyperplasia 1 (100%)
Zymbal's Gland (1) (2)
Autolysis 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (50) (70) (68) (28) (10)
Abscess 1 (1%)
Autolysis 2 (3%) 3 (4%) 3 (4%)
Cyst 1 (2%) 2 (3%)
Fibrosis 1 (1%) 1 (4%)
Fibrosis, Focal 1 (4%)
Hydronephrosis 3 (4%) 2 (3%)
Infarct 1 (2%)
Infiltration Cellular 1 (2%)
Infiltration Cellular, Mononuclear Cell 9 (18%) 7 (10%) 3 (4%) 7 (25%)
Inflammation, Chronic 4 (6%)
Inflammation, Chronic Active 1 (1%) 1 (4%)
Mineralization 3 (4%) 1 (2%) 1 (4%)
Mineralization, Focal 1 (4%)
Nephropathy 60 (86%) 39 (78%) 60 (86%) 56 (82%) 18 (64%) 10 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71UF 71LF 71MLF 71MHF 71HF FEMALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Pigmentation 1 (1%)
Polyarteritis 1 (2%)
Artery, Thrombosis 1 (1%)
Papilla, Necrosis, Coagulative 2 (3%) 2 (7%)
Pelvis, Inflammation, Chronic Active 1 (1%) 1 (2%) 4 (6%) 6 (9%) 1 (4%)
Pelvis, Metaplasia, Squamous 3 (4%) 2 (3%)
Renal Tubule, Hyperplasia 1 (1%) 12 (24%) 23 (33%) 30 (44%) 2 (7%) 2 (20%)
Renal Tubule, Hyperplasia, Oncocytic 1 (1%)
Renal Tubule, Inflammation, Acute 1 (1%) 7 (14%) 3 (4%)
Renal Tubule, Inflammation, Chronic Active 2 (3%) 7 (10%) 1 (10%)
Renal Tubule, Mineralization 1 (1%)
Renal Tubule, Pigmentation 50 (100%) 70 (100%) 68 (100%) 28 (100%) 10 (100%)
Renal Tubule, Regeneration 4 (6%) 5 (10%) 7 (10%) 4 (6%) 7 (25%)
Transitional Epithelium, Hyperplasia 13 (19%) 16 (32%) 44 (63%) 25 (37%) 5 (18%) 1 (10%)
Transitional Epithelium, Mineralization 3 (4%) 4 (8%) 2 (3%) 1 (10%)
Urinary Bladder (70) (50) (70) (66) (28) (10)
Autolysis 1 (1%) 2 (3%)
Calculus Gross Observation 2 (4%) 1 (2%)
Calculus Micro Observation Only 1 (2%)
Fibrosis 1 (1%)
Hemorrhage 2 (3%) 4 (14%)
Hyperplasia, Lymphoid 15 (21%) 2 (4%) 3 (4%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (1%) 1 (2%) 3 (4%) 1 (2%)
Necrosis 1 (2%) 1 (4%)
Fat, Proliferation 4 (6%) 2 (3%) 2 (7%)
Transitional Epithelium, Hyperplasia 1 (1%) 2 (4%) 41 (59%) 52 (79%) 21 (75%) 4 (40%)
Transitional Epithelium, Infiltration
Cellular, Mononuclear Cell 1 (2%)
Transitional Epithelium, Metaplasia, Squamous 1 (2%) 4 (6%) 8 (12%) 3 (11%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71 UM 71LM 71MLM 71MHM 71HM MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 50 70 70 30 10
Scheduled Sacrifice 20 10 10 20 27 7
Early Deaths
Moribund 19 15 34 33 2 3
Dead 5 1 5 7 1
Survivors
Terminal Sacrifice 23 24 21 10
Moribund 2
Dead 1
Animals Examined Microscopically 70 50 69 70 30 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (67) (50) (69) (61) (30) (10)
Autolysis 1 (1%) 1 (2%) 4 (6%) 5 (8%)
Hyperplasia, Lymphoid 1 (1%)
Parasite Metazoan 19 (28%) 17 (34%) 12 (17%) 7 (11%) 1 (3%)
Polyarteritis 1 (2%) 1 (1%)
Ulcer 1 (1%)
Intestine Large, Rectum (65) (50) (68) (69) (30) (10)
Atypia Cellular 2 (3%)
Autolysis 1 (2%) 5 (7%)
Inflammation, Chronic Active 1 (1%)
Parasite Metazoan 7 (11%) 8 (16%) 9 (13%) 2 (3%) 1 (10%)
Artery, Neovascularization 2 (3%)
Artery, Thrombosis 1 (1%)
Epithelium, Hyperplasia 1 (1%) 1 (1%)
Intestine Large, Cecum (68) (50) (69) (60) (28) (10)
Atypia Cellular 1 (1%)
Autolysis 2 (3%) 1 (2%) 3 (4%) 5 (8%)
Hyperplasia, Lymphoid 1 (1%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (4%)
Parasite Metazoan 7 (10%) 8 (16%) 11 (16%) 3 (5%) 1 (4%) 3 (30%)
Ulcer, Acute 1 (2%)
Lymphoid Tissue, Hemorrhage 1 (1%)
Intestine Small, Duodenum (68) (50) (69) (60) (29) (9)
Autolysis 2 (3%) 1 (2%) 3 (4%) 5 (8%)
Ectopic Tissue 1 (1%)
Inflammation, Chronic Active 1 (1%)
Intestine Small, Jejunum (68) (48) (67) (58) (29) (10)
Autolysis 2 (3%) 1 (2%) 5 (7%) 6 (10%)
Intestine Small, Ileum (68) (50) (67) (59) (29) (10)
Autolysis 3 (4%) 1 (2%) 4 (6%) 9 (15%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71 UM 71LM 71MLM 71MHM 71HM MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hyperplasia, Lymphoid 1 (1%) 2 (3%)
Inflammation, Chronic Active 1 (3%)
Liver (70) (50) (69) (70) (30) (10)
Angiectasis 3 (4%) 3 (6%)
Anisokaryosis 1 (10%)
Autolysis 2 (3%) 2 (3%)
Basophilic Focus 10 (14%) 12 (24%) 25 (36%) 28 (40%) 19 (63%) 4 (40%)
Clear Cell Focus 3 (4%) 26 (52%) 39 (57%) 38 (54%) 17 (57%) 6 (60%)
Cyst 1 (1%) 2 (3%)
Cytomegaly 1 (1%) 2 (7%)
Degeneration 12 (17%) 3 (6%) 12 (17%) 4 (6%) 4 (13%)
Developmental Malformation 1 (1%)
Eosinophilic Focus 2 (3%) 13 (26%) 14 (20%) 7 (10%) 2 (7%)
Fatty Change 16 (23%) 11 (22%) 13 (19%) 11 (16%) 10 (33%) 9 (90%)
Fibrosis 1 (1%)
Hematopoietic Cell Proliferation 2 (3%) 4 (6%)
Hemorrhage 1 (1%) 1 (1%) 1 (3%)
Hepatodiaphragmatic Nodule 3 (4%) 2 (4%) 1 (10%)
Hyperplasia 1 (1%)
Infarct 1 (2%) 1 (1%)
Inflammation, Chronic 1 (1%)
Inflammation, Chronic, Granulomatous 2 (3%) 1 (1%)
Inflammation, Chronic Active 10 (14%) 1 (2%) 4 (6%) 7 (10%) 2 (7%)
Mixed Cell Focus 2 (3%) 17 (34%) 8 (12%) 2 (3%) 1 (3%)
Necrosis, Coagulative 10 (14%) 8 (16%) 8 (12%) 10 (14%) 4 (13%) 1 (10%)
Pigmentation 3 (4%) 20 (40%) 48 (70%) 55 (79%) 28 (93%) 8 (80%)
Regeneration 4 (6%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Hyperplasia 56 (80%) 10 (20%) 54 (78%) 60 (86%) 26 (87%) 7 (70%)
Periportal, Inflammation 1 (1%)
Periportal, Inflammation, Chronic 10 (14%) 10 (14%) 17 (57%) 7 (70%)
Periportal, Inflammation, Chronic Active 11 (16%) 12 (24%) 61 (88%) 44 (63%) 11 (37%)
Mesentery (3) (3) (4) (5) (1) (1)
Fibrosis 2 (67%) 2 (50%) 2 (40%)
Hemorrhage 1 (25%) 2 (40%) 1 (100%)
Inflammation, Chronic 1 (100%)
Inflammation, Chronic, Granulomatous 1 (33%)
Inflammation, Chronic Active 1 (33%) 2 (67%) 3 (75%) 4 (80%) 1 (100%)
Necrosis 1 (20%)
Necrosis, Coagulative 2 (67%) 2 (50%) 1 (20%) 1 (100%)
Polyarteritis 1 (33%)
Thrombosis 1 (100%)
Pancreas (70) (50) (69) (60) (30) (10)
Atrophy 17 (24%) 27 (54%) 29 (42%) 21 (35%) 4 (13%) 2 (20%)
Autolysis 2 (3%) 2 (3%)
Cytoplasmic Alteration 1 (2%)
Ectopic Tissue 1 (1%) 1 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71 UM 71LM 71MLM 71MHM 71HM MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hyperplasia 1 (3%)
Infiltration Cellular, Mononuclear Cell 3 (4%) 5 (10%) 2 (3%) 3 (5%) 1 (3%)
Infiltration Cellular, Mixed Cell 1 (2%) 1 (3%)
Inflammation, Chronic 9 (13%) 11 (37%) 5 (50%)
Inflammation, Chronic Active 11 (16%) 28 (56%) 45 (65%) 26 (43%) 1 (3%)
Necrosis, Coagulative 2 (3%)
Pigmentation 1 (1%) 1 (3%)
Vacuolization Cytoplasmic 17 (24%) 2 (4%) 6 (9%) 15 (25%) 1 (10%)
Acinus, Atrophy 1 (1%)
Acinus, Hyperplasia 1 (1%) 1 (2%)
Artery, Fibrosis 1 (1%) 1 (2%)
Artery, Inflammation, Chronic Active 1 (3%)
Artery, Polyarteritis 4 (6%) 8 (16%) 4 (6%) 3 (5%)
Duct, Hyperplasia 1 (1%) 1 (2%)
Pharynx (1)
Palate, Hyperkeratosis 1 (100%)
Salivary Glands (70) (50) (68) (59) (29) (10)
Duct, Parotid Gland, Mineralization 1 (3%)
Duct, Submandibular Gland, Inflammation,
Acute 1 (2%)
Parotid Gland, Inflammation, Chronic 1 (1%)
Sublingual Gland, Atrophy 1 (3%)
Sublingual Gland, Pigmentation 1 (3%)
Submandibular Gland, Inflammation, Chronic 2 (3%)
Submandibular Gland, Metaplasia, Squamous 1 (1%)
Stomach, Forestomach (69) (49) (69) (69) (30) (10)
Acanthosis 2 (7%)
Erosion 1 (1%) 1 (1%)
Fibrosis 1 (1%) 1 (1%)
Hyperkeratosis 5 (7%) 18 (37%) 21 (30%) 20 (29%) 1 (3%) 2 (20%)
Hyperplasia, Basal Cell 11 (16%) 18 (37%) 23 (33%) 23 (33%) 3 (10%) 2 (20%)
Hyperplasia, Squamous 3 (4%) 19 (39%) 25 (36%) 26 (38%) 2 (20%)
Infarct 1 (1%)
Inflammation, Chronic Active 3 (4%) 12 (24%) 11 (16%) 11 (16%) 1 (3%) 1 (10%)
Ulcer 3 (4%) 10 (20%) 15 (22%) 16 (23%) 2 (20%)
Arteriole, Mineralization 1 (1%)
Muscularis, Mineralization 1 (1%) 1 (1%)
Stomach, Glandular (70) (50) (69) (70) (30) (10)
Autolysis 2 (3%) 2 (3%)
Inflammation, Chronic 1 (1%) 1 (3%) 1 (10%)
Inflammation, Chronic Active 3 (4%) 2 (4%) 2 (3%) 3 (4%) 1 (10%)
Arteriole, Mineralization 1 (3%)
Mucosa, Hyperplasia 1 (1%)
Mucosa, Necrosis, Coagulative 1 (1%)
Muscularis, Mineralization 1 (1%) 1 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71 UM 71LM 71MLM 71MHM 71HM MALE
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (70) (50) (69) (59) (30) (10)
Autolysis 1 (2%)
Cardiomyopathy 66 (94%) 46 (92%) 65 (94%) 54 (92%) 23 (77%) 8 (80%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Metaplasia, Osseous 1 (1%)
Polyarteritis 1 (2%)
Thrombosis 2 (3%) 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (70) (50) (68) (60) (30) (10)
Angiectasis 2 (3%) 5 (10%) 13 (19%) 15 (25%) 1 (3%)
Autolysis 2 (3%)
Hematopoietic Cell Proliferation 2 (3%) 1 (2%)
Hyperplasia 5 (7%) 1 (2%) 2 (3%) 1 (2%) 1 (10%)
Necrosis, Coagulative 1 (1%)
Vacuolization Cytoplasmic 23 (33%) 18 (36%) 19 (28%) 11 (18%) 6 (20%)
Bilateral, Vacuolization Cytoplasmic 1 (1%)
Adrenal Medulla (69) (50) (68) (60) (30) (10)
Autolysis 2 (3%)
Fibrosis 1 (1%)
Hematopoietic Cell Proliferation 1 (1%)
Hyperplasia 18 (26%) 25 (50%) 24 (35%) 21 (35%) 1 (3%)
Necrosis, Coagulative 2 (3%)
Bilateral, Hyperplasia 1 (1%)
Islets, Pancreatic (54) (40) (58) (50) (3) (3)
Autolysis 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%) 2 (4%)
Parathyroid Gland (63) (45) (65) (54) (30) (10)
Hyperplasia 4 (6%) 12 (27%) 1 (2%)
Pituitary Gland (65) (50) (65) (58) (29) (10)
Autolysis 1 (2%)
Cyst 1 (2%)
Pars Distalis, Cyst 7 (11%) 4 (8%) 8 (12%) 9 (16%) 3 (10%) 1 (10%)
Pars Distalis, Hyperplasia 23 (35%) 15 (30%) 24 (37%) 32 (55%) 20 (69%) 6 (60%)
Pars Intermedia, Cyst 2 (3%) 1 (2%) 2 (3%)
Pars Nervosa, Cyst 1 (2%) 1 (3%)
Pars Nervosa, Hyperplasia 1 (3%)
Thyroid Gland (69) (50) (69) (61) (30) (10)
Autolysis 2 (3%) 2 (3%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Inflammation, Chronic Active 2 (3%) 1 (2%) 1 (1%)
Ultimobranchial Cyst 3 (6%) 4 (6%) 2 (3%) 1 (3%) 1 (10%)
C-Cell, Hyperplasia 11 (16%) 8 (16%) 5 (7%) 4 (7%) 1 (3%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71 UM 71LM 71MLM 71MHM 71HM MALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Follicle, Cyst 2 (3%) 1 (2%) 7 (10%) 3 (5%)
Follicular Cell, Hyperplasia 3 (4%) 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (2) (2)
Inflammation, Chronic Active 1 (50%) 2 (100%)
Epididymis (70) (50) (69) (60) (30) (10)
Aspermia 1 (1%)
Autolysis 2 (3%)
Inflammation, Chronic 1 (3%)
Inflammation, Chronic Active 3 (4%) 2 (4%) 10 (14%) 3 (5%)
Vacuolization Cytoplasmic 1 (1%) 1 (2%) 1 (10%)
Preputial Gland (67) (48) (66) (56) (29) (10)
Abscess 6 (9%) 1 (2%) 1 (2%)
Cyst 2 (3%) 1 (2%) 1 (2%)
Hyperplasia 2 (3%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 7 (10%) 1 (2%) 2 (4%) 8 (28%) 2 (20%)
Inflammation, Chronic Active 57 (85%) 44 (92%) 59 (89%) 45 (80%) 17 (59%) 7 (70%)
Prostate (70) (50) (68) (59) (30) (10)
Abscess 3 (6%) 1 (1%) 1 (2%)
Fibrosis 1 (2%)
Inflammation, Acute 2 (3%) 2 (4%) 11 (37%) 4 (40%)
Inflammation, Chronic 1 (3%)
Inflammation, Chronic Active 17 (24%) 22 (44%) 25 (37%) 24 (41%) 7 (23%) 4 (40%)
Metaplasia, Squamous 1 (1%) 11 (22%) 6 (9%) 1 (2%)
Polyarteritis 1 (2%)
Epithelium, Hyperplasia 8 (11%) 4 (8%) 2 (3%) 1 (2%) 1 (3%)
Seminal Vesicle (69) (50) (69) (60) (30) (10)
Atrophy 1 (1%) 30 (60%) 35 (51%) 23 (38%)
Autolysis 1 (1%)
Inflammation, Chronic Active 3 (6%) 2 (3%) 1 (2%)
Metaplasia, Squamous 1 (2%)
Testes (70) (50) (69) (68) (30) (10)
Abscess 1 (10%)
Abscess, Chronic 1 (1%) 1 (3%)
Atrophy 1 (1%) 1 (1%) 1 (3%)
Infarct 1 (2%) 1 (1%) 1 (3%)
Infarct, Chronic 1 (1%)
Inflammation, Chronic 1 (1%) 2 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71 UM 71LM 71MLM 71MHM 71HM MALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Chronic Active 1 (3%)
Mineralization 1 (2%)
Polyarteritis 1 (1%)
Interstitial Cell, Hyperplasia 27 (39%) 12 (24%) 32 (46%) 32 (47%) 19 (63%) 8 (80%)
Seminiferous Tubule, Atrophy 43 (61%) 37 (74%) 55 (80%) 39 (57%) 7 (23%) 3 (30%)
Seminiferous Tubule, Mineralization 8 (11%) 2 (3%) 6 (9%) 2 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (50) (69) (60) (30) (10)
Myelofibrosis 1 (10%)
Sternal, Autolysis 1 (1%)
Sternal, Hypoplasia 1 (2%)
Sternal, Myelofibrosis 1 (1%)
Lymph Node (19) (6) (18) (25) (6) (2)
Deep Cervical, Hyperplasia 1 (4%)
Lumbar, Hyperplasia 1 (17%) 1 (4%)
Lumbar, Pigmentation 1 (6%)
Mediastinal, Hemorrhage 2 (11%) 4 (22%) 2 (8%) 3 (50%) 1 (50%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (17%) 2 (8%)
Mediastinal, Pigmentation 1 (5%) 3 (12%) 1 (17%)
Mediastinal, Sinus, Ectasia 1 (5%)
Pancreatic, Hemorrhage 1 (6%) 1 (50%)
Pancreatic, Hyperplasia 1 (17%) 1 (6%) 2 (8%)
Pancreatic, Infiltration Cellular, Histiocyte 2 (33%) 10 (56%) 23 (92%) 2 (33%) 1 (50%)
Pancreatic, Inflammation, Chronic Active 1 (6%)
Pancreatic, Pigmentation 4 (16%) 3 (50%)
Renal, Hemorrhage 1 (5%) 1 (17%)
Renal, Infiltration Cellular, Histiocyte 1 (5%) 1 (6%)
Renal, Pigmentation 1 (5%) 1 (17%)
Lymph Node, Mandibular (70) (50) (64) (59) (27) (8)
Hemorrhage 12 (17%) 5 (10%) 7 (11%) 8 (14%) 4 (15%) 1 (13%)
Hyperplasia 11 (16%) 7 (14%) 7 (11%) 4 (7%)
Hyperplasia, Plasma Cell 1 (4%)
Infiltration Cellular, Histiocyte 2 (3%) 2 (3%) 8 (14%) 2 (7%)
Inflammation, Chronic Active 1 (1%)
Pigmentation 1 (4%)
Lymph Node, Mesenteric (68) (50) (67) (60) (30) (9)
Autolysis 1 (1%)
Depletion Lymphoid 1 (1%)
Hemorrhage 1 (1%) 1 (2%) 2 (7%)
Hyperplasia 1 (1%) 2 (3%)
Infiltration Cellular, Histiocyte 64 (94%) 50 (100%) 66 (99%) 60 (100%) 30 (100%) 9 (100%)
Pigmentation 10 (15%) 1 (1%) 7 (12%) 23 (77%) 7 (78%)
Spleen (70) (50) (68) (62) (30) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71 UM 71LM 71MLM 71MHM 71HM MALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Autolysis 1 (1%) 2 (3%)
Depletion Lymphoid 12 (17%) 3 (6%) 2 (3%) 1 (3%)
Fibrosis 6 (9%) 3 (6%) 2 (3%) 5 (8%)
Hyperplasia, Re Cell 1 (1%)
Infiltration Cellular, Histiocyte 1 (2%)
Necrosis, Coagulative 2 (3%)
Pigmentation 2 (3%)
Thymus (56) (41) (51) (53) (26) (9)
Cyst 3 (5%)
Depletion Lymphoid 3 (5%) 4 (10%) 5 (10%) 10 (19%) 20 (77%) 4 (44%)
Hemorrhage 1 (2%) 1 (2%) 5 (9%) 1 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (39) (29) (34) (29) (15) (7)
Galactocele 3 (8%) 1 (3%) 1 (3%)
Hyperplasia 25 (64%) 25 (86%) 22 (65%) 17 (59%) 14 (93%) 7 (100%)
Skin (70) (48) (68) (60) (29) (10)
Abscess 2 (4%) 1 (1%)
Cyst Epithelial Inclusion 1 (1%) 3 (4%)
Fibrosis 1 (1%)
Inflammation, Chronic 1 (3%)
Inflammation, Chronic Active 1 (1%) 2 (3%) 2 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (50) (69) (60) (30) (10)
Cranium, Abscess 1 (2%)
Joint, Tarsal, Hyperostosis 1 (1%)
Joint, Tarsal, Inflammation, Chronic Active 1 (1%)
Rib, Hyperostosis 1 (2%)
Skeletal Muscle (2) (1) (1)
Fibrosis 1 (100%)
Polyarteritis 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (50) (69) (60) (30) (10)
Infarct 3 (4%)
Spinal Cord (5) (1) (1) (4)
Infarct 1 (20%) 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71 UM 71LM 71MLM 71MHM 71HM MALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (50) (69) (62) (30) (10)
Crystals 1 (1%)
Fibrosis 3 (4%)
Foreign Body 1 (2%)
Hemorrhage 2 (3%)
Infiltration Cellular, Histiocyte 24 (34%) 23 (46%) 34 (49%) 26 (42%) 7 (23%) 2 (20%)
Inflammation, Chronic Active 1 (2%) 5 (7%) 3 (5%)
Metaplasia, Osseous 1 (2%)
Mineralization 1 (3%)
Necrosis, Coagulative 1 (1%)
Alveolar Epithelium, Hyperplasia 7 (10%) 2 (4%) 7 (10%) 1 (2%) 1 (3%)
Alveolus, Mineralization 1 (1%)
Artery, Mineralization 36 (51%) 17 (34%) 41 (59%) 34 (55%) 13 (43%) 7 (70%)
Artery, Thrombosis 1 (1%)
Bronchiole, Epithelium, Hyperplasia 1 (1%)
Mediastinum, Polyarteritis 2 (4%)
Nose (68) (50) (69) (60) (30) (10)
Autolysis 1 (1%)
Foreign Body 2 (4%) 7 (10%) 1 (2%)
Hemorrhage 3 (5%)
Inflammation, Chronic Active 26 (38%) 25 (50%) 27 (39%) 18 (30%)
Metaplasia, Squamous 10 (15%) 7 (14%) 7 (10%) 6 (10%)
Ulcer 2 (3%)
Glands, Hyperplasia 9 (13%) 3 (5%)
Glands, Inflammation, Acute 3 (4%) 8 (27%) 3 (30%)
Glands, Inflammation, Chronic Active 1 (1%) 3 (10%)
Lumen, Inflammation, Acute 1 (10%)
Nasolacrimal Duct, Inflammation, Chronic
Active 1 (1%) 1 (3%)
Respiratory Epithelium, Hyperplasia 2 (3%) 1 (1%) 2 (3%)
Respiratory Epithelium, Metaplasia, Squamous 1 (3%)
Trachea (70) (50) (69) (60) (30) (10)
Autolysis 1 (2%)
Inflammation, Chronic Active 1 (2%) 3 (4%) 2 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (4) (7) (2) (1)
Acanthosis 1 (25%) 1 (14%) 1 (50%)
Hyperkeratosis 1 (25%)
Hyperplasia, Basal Cell 1 (25%) 1 (14%) 1 (50%)
Inflammation, Chronic Active 2 (50%)
Ulcer 1 (25%)
Submucosa, Abscess 1 (100%)
Eye (6) (3) (1) (6) (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71 UM 71LM 71MLM 71MHM 71HM MALE
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Cataract 1 (100%)
Synechia 1 (17%)
Anterior, Synechia 1 (17%)
Conjunctiva, Inflammation, Chronic Active 1 (100%)
Cornea, Fibrosis 1 (100%)
Cornea, Inflammation, Chronic Active 1 (17%)
Cornea, Neovascularization 1 (100%)
Lens, Cataract 3 (50%)
Retina, Degeneration 1 (17%) 1 (100%) 3 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (50) (69) (70) (30) (10)
Autolysis 2 (3%) 1 (1%) 4 (6%) 1 (3%)
Cyst 4 (6%) 3 (6%) 1 (1%) 1 (10%)
Cyst, Multiple 1 (1%)
Fibrosis, Focal 1 (2%)
Granuloma 1 (1%)
Hydronephrosis 1 (1%)
Infiltration Cellular, Mononuclear Cell 9 (18%) 9 (13%) 9 (13%) 7 (23%)
Infiltration Cellular, Mixed Cell 1 (3%)
Inflammation, Chronic 4 (6%)
Nephropathy 60 (86%) 40 (80%) 59 (86%) 59 (84%) 20 (67%) 10 (100%)
Collecting Tubule, Mineralization 1 (1%)
Renal Tubule, Degeneration, Hyaline 10 (20%) 11 (16%) 11 (16%) 10 (33%)
Renal Tubule, Hyperplasia 9 (13%) 30 (60%) 25 (36%) 21 (30%) 1 (3%) 1 (10%)
Renal Tubule, Hyperplasia, Oncocytic 1 (2%) 1 (1%)
Renal Tubule, Inflammation, Chronic Active 14 (20%) 10 (20%) 22 (32%) 14 (20%) 1 (3%)
Renal Tubule, Mineralization 1 (1%) 2 (4%) 13 (19%) 4 (6%)
Renal Tubule, Pigmentation 5 (7%) 50 (100%) 68 (99%) 69 (99%) 30 (100%) 9 (90%)
Renal Tubule, Regeneration 10 (14%) 10 (20%) 10 (14%) 9 (13%) 10 (33%)
Transitional Epithelium, Hyperplasia 30 (43%) 40 (80%) 51 (74%) 39 (56%) 11 (37%) 1 (10%)
Urinary Bladder (70) (48) (67) (70) (28) (10)
Autolysis 1 (1%) 1 (1%)
Calculus Micro Observation Only 2 (3%) 1 (1%) 2 (7%)
Edema 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 2 (3%)
Hyperplasia, Lymphoid 4 (6%)
Inflammation, Chronic 1 (1%) 1 (4%)
Inflammation, Chronic Active 1 (1%) 3 (6%) 5 (7%)
Metaplasia, Squamous 1 (1%)
Polyarteritis 1 (2%)
Fat, Proliferation 1 (4%)
Muscularis, Mineralization 1 (4%)
Serosa, Mineralization 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71 UM 71LM 71MLM 71MHM 71HM MALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Hyperplasia 1 (1%) 5 (10%) 17 (25%) 33 (47%) 9 (32%)
Transitional Epithelium, Metaplasia, Squamous 3 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
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