TR 383 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
1-AMINO 2,4-DIBROMOANTHRAQUINONE
NTP Experiment-Test: 05061-01 Report: PEIRPT05
Study Type: CHRONIC Date: 05/19/95
Route: DOSED FEED Time: 14:37:39
Facility: TSI Mason Research
Chemical CAS #: 81-49-2
Lock Date: 03/25/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71UF 71LF 71MLF 71MHF 71HF FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 50 70 70 30 10
Scheduled Sacrifice 20 10 10 20 21 9
Early Deaths
Moribund 8 5 15 29 5 1
Dead 4 3 7 8 3
Survivors
Terminal Sacrifice 37 32 38 12
Dead 1
Wrong Sex 1 1
Animals Examined Microscopically 70 50 70 69 28 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (70) (50) (67) (58) (28) (10)
Intestine Large, Colon (69) (50) (69) (57) (28) (10)
Adenocarcinoma 2 (3%) 1 (2%)
Adenocarcinoma, Multiple 1 (2%)
Polyp Adenomatous 1 (1%) 1 (2%)
Polyp Adenomatous, Multiple 1 (2%) 1 (1%) 1 (2%)
Intestine Large, Rectum (69) (50) (70) (67) (27) (10)
Adenocarcinoma 1 (2%) 18 (26%) 6 (9%)
Adenocarcinoma, Multiple 1 (1%) 1 (1%)
Polyp Adenomatous 10 (20%) 8 (11%) 14 (21%) 2 (7%) 5 (50%)
Polyp Adenomatous, Multiple 17 (34%) 45 (64%) 31 (46%) 1 (4%)
Intestine Large, Cecum (70) (50) (70) (57) (28) (10)
Polyp Adenomatous 1 (1%)
Intestine Small, Jejunum (68) (50) (69) (56) (27) (10)
Intestine Small, Ileum (69) (49) (69) (54) (28) (10)
Leiomyoma 1 (1%)
Liver (70) (50) (70) (68) (28) (10)
Cholangioma 1 (1%)
Hepatocellular Carcinoma 5 (10%) 6 (9%) 7 (10%) 8 (29%) 3 (30%)
Hepatocellular Carcinoma, Multiple 7 (14%) 51 (73%) 44 (65%) 8 (29%) 3 (30%)
Hepatocellular Adenoma 10 (20%) 8 (11%) 10 (15%) 5 (18%) 5 (50%)
Hepatocellular Adenoma, Multiple 18 (36%) 39 (56%) 27 (40%) 7 (25%) 1 (10%)
Hepatocholangiocarcinoma 10 (14%) 8 (12%)
Hepatocholangiocarcinoma, Multiple 1 (1%) 5 (7%)
Hepatocholangioma 1 (1%)
Hepatocholangioma, Multiple 1 (1%)
Mesentery (4) (6) (1) (5) (1)
Hepatocellular Carcinoma, Metastatic, Liver 3 (60%)
Pancreas (70) (50) (70) (58) (28) (10)
Page 2
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71UF 71LF 71MLF 71MHF 71HF FEMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Adenoma 2 (3%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Pharynx (1) (1)
Palate, Squamous Cell Papilloma, Multiple 1 (100%)
Stomach, Forestomach (69) (50) (70) (67) (28) (10)
Squamous Cell Carcinoma 1 (2%) 1 (1%) 1 (1%)
Squamous Cell Papilloma 1 (1%)
Stomach, Glandular (70) (50) (70) (68) (28) (10)
Hepatocellular Carcinoma, Metastatic, Liver 1 (1%)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
Tooth (1) (1) (1)
Gingiva, Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (70) (50) (70) (59) (28) (10)
Hepatocellular Carcinoma, Metastatic, Liver 1 (1%) 2 (3%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (67) (50) (69) (58) (27) (10)
Adenoma 2 (3%) 1 (2%)
Carcinoma, Metastatic, Kidney 1 (2%)
Adrenal Medulla (67) (50) (69) (58) (27) (10)
Pheochromocytoma Complex 1 (1%)
Pheochromocytoma Benign 2 (3%) 3 (6%) 1 (1%) 2 (3%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (50) (40) (60) (47) (7) (1)
Adenoma 1 (3%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Parathyroid Gland (63) (47) (67) (48) (25) (10)
Adenoma 1 (2%)
Pituitary Gland (70) (49) (70) (57) (28) (10)
Pars Distalis, Adenoma 29 (41%) 16 (33%) 25 (36%) 13 (23%) 2 (7%) 2 (20%)
Pars Distalis, Adenoma, Multiple 5 (7%) 3 (6%) 7 (10%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (70) (50) (70) (59) (28) (10)
Adenoma 1 (10%)
C-Cell, Adenoma 5 (7%) 5 (10%) 5 (7%)
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma 1 (1%) 1 (1%)
Follicular Cell, Adenoma 1 (2%) 1 (1%) 2 (3%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71UF 71LF 71MLF 71MHF 71HF FEMALE
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (1) (1) (1)
Basosquamous Tumor Malignant 1 (100%)
Neoplasm NOS 1 (100%)
Sarcoma 2 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (65) (46) (68) (58) (27) (10)
Adenoma 5 (8%) 3 (7%) 3 (4%) 2 (3%)
Ovary (70) (50) (70) (61) (28) (10)
Granulosa Cell Tumor Benign 1 (1%) 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (1%) 1 (2%)
Uterus (70) (50) (70) (60) (28) (10)
Adenocarcinoma 1 (1%)
Hemangioma 1 (1%)
Polyp Stromal 8 (11%) 12 (24%) 8 (11%) 6 (10%) 1 (4%) 1 (10%)
Polyp Stromal, Multiple 1 (1%) 3 (6%)
Sarcoma Stromal 1 (1%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (50) (70) (59) (28) (10)
Lymph Node (7) (11) (28) (24) (9) (1)
Mediastinal, Hepatocellular Carcinoma,
Metastatic, Liver 1 (4%)
Lymph Node, Mandibular (66) (49) (66) (53) (27) (9)
Lymph Node, Mesenteric (70) (50) (69) (60) (28) (9)
Spleen (70) (50) (70) (58) (28) (10)
Hepatocellular Carcinoma, Metastatic, Liver 1 (1%)
Lipoma 1 (2%)
Thymus (62) (41) (61) (55) (22) (10)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (65) (38) (54) (47) (19) (7)
Adenocarcinoma 2 (3%)
Fibroadenoma 18 (28%) 8 (21%) 9 (17%) 5 (11%)
Fibroadenoma, Multiple 4 (6%) 2 (5%)
Fibroma 1 (2%)
Skin (70) (49) (70) (60) (28) (10)
Squamous Cell Papilloma 1 (1%) 1 (1%) 1 (2%)
Pinna, Granular Cell Tumor Benign 1 (1%)
Page 4
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71UF 71LF 71MLF 71MHF 71HF FEMALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Pinna, Squamous Cell Papilloma 2 (3%) 2 (3%)
Subcutaneous Tissue, Fibroma 2 (3%) 2 (4%) 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (50) (70) (59) (28) (10)
Basosquamous Tumor Malignant, Metastatic,
Tissue NOS 1 (2%)
Squamous Cell Carcinoma, Metastatic,
Uncertain Primary Site 1 (2%)
Skeletal Muscle (1)
Rhabdomyosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (50) (70) (59) (28) (10)
Oligodendroglioma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (50) (70) (64) (28) (10)
Alveolar/Bronchiolar Adenoma 1 (1%) 2 (4%) 1 (1%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 22 (31%) 24 (38%) 1 (4%) 1 (10%)
Neoplasm NOS, Metastatic, Uncertain Primary
Site 1 (2%)
Sarcoma, Metastatic, Thymus 1 (1%)
Squamous Cell Carcinoma 1 (2%)
Nose (70) (50) (70) (59) (28) (10)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (8) (3)
Zymbal's Gland (1) (2)
Adenoma 1 (50%)
Carcinoma 1 (50%)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71UF 71LF 71MLF 71MHF 71HF FEMALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (50) (70) (68) (28) (10)
Adenoma 1 (4%)
Squamous Cell Carcinoma, Metastatic, Urinary
Bladder 1 (1%)
Pelvis, Transitional Epithelium, Carcinoma 1 (2%)
Pelvis, Transitional Epithelium, Papilloma 1 (1%)
Renal Tubule, Adenoma 3 (6%) 11 (16%) 11 (16%) 1 (4%) 3 (30%)
Renal Tubule, Adenoma, Multiple 5 (7%) 5 (7%) 1 (4%)
Renal Tubule, Carcinoma 2 (3%)
Urinary Bladder (70) (50) (70) (66) (28) (10)
Carcinoma 2 (3%) 4 (14%) 1 (10%)
Papilloma 1 (2%) 1 (4%)
Squamous Cell Carcinoma 2 (3%)
Transitional Epithelium, Carcinoma 8 (11%) 16 (24%) 1 (4%)
Transitional Epithelium, Papilloma 2 (4%) 6 (9%) 9 (14%) 1 (4%)
Transitional Epithelium, Papilloma, Multiple 1 (1%)
Transitional Epithelium, Squamous Cell
Carcinoma 1 (1%)
Transitional Epithelium, Squamous Cell
Papilloma 1 (1%) 1 (2%)
Transitional Epithelium, Squamous Cell
Papilloma, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(70) *(50) *(70) *(69) *(28) *(10)
Leukemia Mononuclear 9 (13%) 1 (2%) 5 (7%) 1 (1%)
Lymphoma Malignant Histiocytic 1 (1%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71UF 71LF 71MLF 71MHF 71HF FEMALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 40 61 57 21 9
Total Primary Neoplasms 104 148 307 252 44 25
Total Animals with Benign Neoplasms 45 40 61 54 16 9
Total Benign Neoplasms 87 128 198 153 23 18
Total Animals with Malignant Neoplasms 16 15 60 55 17 6
Total Malignant Neoplasms 17 20 108 99 21 7
Total Animals with Metastatic Neoplasms 1 2 22 27 1 1
Total Metastatic Neoplasm 1 2 26 38 1 1
Total Animals with Malignant Neoplasms 2
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71 UM 71LM 71MLM 71MHM 71HM MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 50 70 70 30 10
Scheduled Sacrifice 20 10 10 20 27 7
Early Deaths
Moribund 19 15 34 33 2 3
Dead 5 1 5 7 1
Survivors
Terminal Sacrifice 23 24 21 10
Moribund 2
Dead 1
Animals Examined Microscopically 70 50 69 70 30 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (67) (50) (69) (61) (30) (10)
Adenocarcinoma 1 (1%) 4 (7%)
Polyp Adenomatous 1 (2%) 1 (3%)
Polyp Adenomatous, Multiple 1 (1%) 3 (5%)
Intestine Large, Rectum (65) (50) (68) (69) (30) (10)
Adenocarcinoma 1 (2%) 10 (15%) 12 (17%) 2 (7%)
Adenocarcinoma, Multiple 3 (4%)
Polyp Adenomatous 12 (24%) 17 (25%) 16 (23%) 6 (20%) 2 (20%)
Polyp Adenomatous, Multiple 1 (2%) 34 (50%) 30 (43%) 1 (3%) 1 (10%)
Intestine Large, Cecum (68) (50) (69) (60) (28) (10)
Intestine Small, Duodenum (68) (50) (69) (60) (29) (9)
Intestine Small, Jejunum (68) (48) (67) (58) (29) (10)
Intestine Small, Ileum (68) (50) (67) (59) (29) (10)
Liver (70) (50) (69) (70) (30) (10)
Cholangiocarcinoma 1 (1%)
Cholangioma 2 (3%)
Hepatocellular Carcinoma 1 (1%) 11 (22%) 12 (17%) 13 (19%) 8 (27%) 4 (40%)
Hepatocellular Carcinoma, Multiple 1 (2%) 43 (62%) 40 (57%) 13 (43%) 3 (30%)
Hepatocellular Adenoma 1 (1%) 10 (20%) 18 (26%) 12 (17%) 5 (17%) 7 (70%)
Hepatocellular Adenoma, Multiple 10 (20%) 23 (33%) 26 (37%) 5 (17%)
Hepatocholangiocarcinoma 5 (7%) 2 (3%) 1 (10%)
Hepatocholangiocarcinoma, Multiple 1 (1%)
Hepatocholangioma 1 (1%) 1 (1%)
Myxoma 1 (1%)
Mesentery (3) (3) (4) (5) (1) (1)
Pancreas (70) (50) (69) (60) (30) (10)
Adenocarcinoma, Metastatic, Intestine Large,
Rectum 1 (2%)
Adenoma 3 (4%)
Page 8
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71 UM 71LM 71MLM 71MHM 71HM MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Salivary Glands (70) (50) (68) (59) (29) (10)
Stomach, Forestomach (69) (49) (69) (69) (30) (10)
Squamous Cell Carcinoma 1 (1%)
Squamous Cell Papilloma 2 (4%) 1 (1%) 1 (3%)
Stomach, Glandular (70) (50) (69) (70) (30) (10)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (70) (50) (69) (59) (30) (10)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (70) (50) (68) (60) (30) (10)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Adrenal Medulla (69) (50) (68) (60) (30) (10)
Ganglioneuroma 1 (1%)
Pheochromocytoma Malignant 1 (1%) 2 (4%) 1 (1%)
Pheochromocytoma Benign 11 (16%) 12 (24%) 11 (16%) 5 (8%)
Bilateral, Pheochromocytoma Benign 1 (1%) 3 (6%) 2 (3%) 2 (3%)
Islets, Pancreatic (54) (40) (58) (50) (3) (3)
Adenoma 2 (4%) 2 (5%) 1 (2%)
Parathyroid Gland (63) (45) (65) (54) (30) (10)
Adenoma 1 (2%)
Pituitary Gland (65) (50) (65) (58) (29) (10)
Pars Distalis, Adenoma 21 (32%) 12 (24%) 9 (14%) 10 (17%) 1 (3%)
Pars Distalis, Adenoma, Multiple 1 (2%) 2 (4%) 1 (2%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (69) (50) (69) (61) (30) (10)
Adenoma 1 (1%) 1 (2%)
C-Cell, Adenoma 10 (14%) 5 (10%) 3 (4%) 3 (5%)
Follicular Cell, Adenoma 2 (3%) 1 (2%) 1 (3%)
Follicular Cell, Carcinoma 2 (3%) 3 (6%) 1 (1%) 3 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71 UM 71LM 71MLM 71MHM 71HM MALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (2) (2)
Epididymis (70) (50) (69) (60) (30) (10)
Preputial Gland (67) (48) (66) (56) (29) (10)
Adenocarcinoma 1 (1%) 1 (2%)
Adenoma 3 (4%) 2 (4%) 1 (2%) 1 (2%)
Carcinoma 1 (3%)
Prostate (70) (50) (68) (59) (30) (10)
Seminal Vesicle (69) (50) (69) (60) (30) (10)
Testes (70) (50) (69) (68) (30) (10)
Adenoma 1 (1%)
Bilateral, Interstitial Cell, Adenoma 40 (57%) 34 (68%) 49 (71%) 38 (56%) 1 (10%)
Interstitial Cell, Adenoma 5 (7%) 3 (6%) 6 (9%) 10 (15%) 3 (10%) 3 (30%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (50) (69) (60) (30) (10)
Lymph Node (19) (6) (18) (25) (6) (2)
Lumbar, Adenocarcinoma, Metastatic,
Intestine Large, Rectum 1 (6%)
Mediastinal, Hepatocellular Carcinoma,
Metastatic, Liver 1 (17%)
Lymph Node, Mandibular (70) (50) (64) (59) (27) (8)
Lymph Node, Mesenteric (68) (50) (67) (60) (30) (9)
Adenocarcinoma, Metastatic, Intestine Large,
Colon 1 (1%)
Spleen (70) (50) (68) (62) (30) (10)
Fibroma 1 (1%)
Sarcoma 1 (2%)
Thymus (56) (41) (51) (53) (26) (9)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (39) (29) (34) (29) (15) (7)
Adenocarcinoma 1 (3%)
Fibroadenoma 1 (3%)
Fibroadenoma, Multiple 1 (3%)
Skin (70) (48) (68) (60) (29) (10)
Basal Cell Adenoma 1 (1%) 1 (2%)
Basal Cell Carcinoma 2 (3%)
Keratoacanthoma 1 (1%) 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (1%) 3 (4%) 1 (2%)
Trichoepithelioma 1 (1%)
Pinna, Squamous Cell Papilloma 2 (4%) 2 (3%) 1 (2%)
Page 10
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71 UM 71LM 71MLM 71MHM 71HM MALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Fibroma 2 (3%) 3 (4%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (1%) 1 (1%)
Subcutaneous Tissue, Lipoma 1 (1%)
Subcutaneous Tissue, Sarcoma 1 (1%) 3 (6%) 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2) (1) (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (50) (69) (60) (30) (10)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Oligodendroglioma Benign 1 (1%)
Cerebrum, Meningioma Benign 1 (1%)
Meninges, Granular Cell Tumor Benign 1 (1%)
Peripheral Nerve (2)
Squamous Cell Carcinoma, Metastatic,
Uncertain Primary Site 1 (50%)
Spinal Cord (5) (1) (1) (4)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (50) (69) (62) (30) (10)
Adenocarcinoma, Metastatic, Kidney 1 (1%)
Adenocarcinoma, Metastatic, Intestine Large,
Colon 1 (1%)
Alveolar/Bronchiolar Adenoma 1 (1%) 2 (4%) 2 (3%) 4 (6%) 1 (3%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (3%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 18 (26%) 19 (31%) 7 (23%) 5 (50%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (10%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (1%)
Sarcoma, Metastatic, Kidney 1 (2%)
Sarcoma, Metastatic, Skin 1 (1%)
Mediastinum, Alveolar/Bronchiolar Carcinoma 1 (2%)
Nose (68) (50) (69) (60) (30) (10)
Trachea (70) (50) (69) (60) (30) (10)
____________________________________________________________________________________________________________________________________
Page 11
NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71 UM 71LM 71MLM 71MHM 71HM MALE
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (4) (7) (2) (1)
Fibrosarcoma 1 (25%)
Eye (6) (3) (1) (6) (1)
Zymbal's Gland (1) (1) (1) (2)
Carcinoma 1 (100%) 1 (100%) 1 (50%)
Squamous Cell Carcinoma 1 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (50) (69) (70) (30) (10)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 1 (3%)
Pelvis, Transitional Epithelium, Papilloma 1 (1%)
Renal Tubule, Adenoma 2 (3%) 6 (12%) 7 (10%) 11 (16%) 2 (7%) 3 (30%)
Renal Tubule, Adenoma, Multiple 4 (8%) 4 (6%) 5 (7%)
Renal Tubule, Carcinoma 2 (3%) 1 (1%)
Urinary Bladder (70) (48) (67) (70) (28) (10)
Papilloma 4 (14%)
Squamous Cell Carcinoma 1 (4%)
Transitional Epithelium, Carcinoma 1 (1%) 4 (6%) 1 (4%)
Transitional Epithelium, Papilloma 1 (2%) 2 (3%) 8 (11%)
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SYSTEMIC LESIONS
Multiple Organs *(70) *(50) *(69) *(70) *(30) *(10)
Leukemia Mononuclear 25 (36%) 5 (10%) 3 (4%) 3 (4%)
Mesothelioma Malignant 1 (1%) 1 (2%) 1 (1%) 2 (3%) 1 (3%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 05061-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 1-AMINO 2,4-DIBROMOANTHRAQUINONE Date: 05/19/95
Route: DOSED FEED Time: 14:37:39
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FISCHER 344 RATS MALE UNTREATE 0.2% 0.5% 1.0% 2.0% 2.0%
D 71 UM 71LM 71MLM 71MHM 71HM MALE
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TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 57 40 61 58 26 10
Total Primary Neoplasms 149 160 299 286 58 25
Total Animals with Benign Neoplasms 57 40 60 57 20 10
Total Benign Neoplasms 112 129 211 194 31 17
Total Animals with Malignant Neoplasms 29 24 57 55 21 8
Total Malignant Neoplasms 37 31 88 92 27 8
Total Animals with Metastatic Neoplasms 2 3 20 22 7 6
Total Metastatic Neoplasm 2 3 23 22 9 7
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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