TR 383 Rat Pathology Tables
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
Facility: TSI Mason Research
Chemical CAS #: 81-49-2
Lock Date: 03/25/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 2| 7| 7| 7| 4| 2| 7| 7| 7| 6| 2| 7| 7| 4| 2| 2| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 0| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| 0| 6| 3| 3| 6| 8| 8| 3| 3| 3| 7| 6|
| 4| 4| 1| 2| 1| 4| 4| 4| 2| 1| 5| 5| 5| 6| 8| 5| 5| 2| 1| 1| 6| 6| 6| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Parasite Metazoan | 1 2 1 1 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Parasite Metazoan | 2 1 1 2 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | 1 X 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + M + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Ulcer | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 2 1 |
Clear Cell Focus | 1 |
Eosinophilic Focus | 2 1 2 1 2 |
Fatty Change | 2 3 |
Hepatodiaphragmatic Nodule | X X X |
Hepatodiaphragmatic Nodule, Multiple | X |
Infarct | |
Inflammation, Chronic, Granulomatous | 2 1 1|
Inflammation, Chronic Active | 1 2 1 1 1 1 1 1 |
Mixed Cell Focus | |
Necrosis, Coagulative | 1 1 |
Pigmentation | 1 |
Thrombosis | |
Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 1 1 1 1 1 |
Centrilobular, Hemorrhage | |
Centrilobular, Necrosis, Coagulative | |
Periportal, Inflammation, Chronic | 1 1 1 1|
Periportal, Inflammation, Chronic | |
Active | 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fibrosis | 1 2 |
Inflammation, Chronic Active | 4 1 3 |
Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 2| 7| 7| 7| 4| 2| 7| 7| 7| 6| 2| 7| 7| 4| 2| 2| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 0| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| 0| 6| 3| 3| 6| 8| 8| 3| 3| 3| 7| 6|
| 4| 4| 1| 2| 1| 4| 4| 4| 2| 1| 5| 5| 5| 6| 8| 5| 5| 2| 1| 1| 6| 6| 6| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Atrophy | 1 1 1 1 1 1 1 1 1 |
Autolysis | 2 |
Ectopic Tissue | |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 |
Inflammation, Chronic | 1 1 1 1|
Inflammation, Chronic Active | 1 1 1 3 1 1 1 1 1 1 1 1 1 1 |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sublingual Gland, Inflammation, | |
Chronic Active | 1 |
Submandibular Gland, Inflammation, | |
Chronic Active | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell | 1 |
Hyperplasia, Squamous | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Inflammation, Chronic Active | 2 |
Necrosis, Coagulative | |
Muscularis, Mineralization | 1 2 |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 2 1 1 1 1 2 2 2 2 2 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + M + + + +|
Angiectasis | 2 2 1 1 1 2 2 1 1 1|
Autolysis | |
Hyperplasia | 1 2 |
Hypertrophy | 3 |
Necrosis, Coagulative | |
Thrombosis, Multiple | |
Vacuolization Cytoplasmic | 1 1 3 3 3 2 |
Capsule, Fibrosis | |
Capsule, Hyperplasia | |
Capsule, Inflammation, Chronic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +|
Autolysis | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 2| 7| 7| 7| 4| 2| 7| 7| 7| 6| 2| 7| 7| 4| 2| 2| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 0| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| 0| 6| 3| 3| 6| 8| 8| 3| 3| 3| 7| 6|
| 4| 4| 1| 2| 1| 4| 4| 4| 2| 1| 5| 5| 5| 6| 8| 5| 5| 2| 1| 1| 6| 6| 6| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 1 1 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 4 |
Pars Distalis, Cyst | 1 1 2 1 1 1 2 1 1|
Pars Distalis, Hemorrhage | 1 |
Pars Distalis, Hyperplasia | 1 1 2 2 |
Pars Intermedia, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Infiltration Cellular, Mononuclear | |
Cell | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + + + + + M + + + + + + M + + + +|
Abscess | 2 |
Cyst | 4 |
Infiltration Cellular, Mononuclear | |
Cell | |
Inflammation, Chronic | 1 2 2 1|
Inflammation, Chronic Active | 2 1 1 1 1 3 1 3 1 1 3 |
Duct, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 2 2 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis | |
Hydrometra | 4 1 3 |
Inflammation, Acute | 1 |
Endometrium, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
__________________________________________________________________________|
Lymph Node | M M + M M |
Mediastinal, Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 2| 7| 7| 7| 4| 2| 7| 7| 7| 6| 2| 7| 7| 4| 2| 2| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 0| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| 0| 6| 3| 3| 6| 8| 8| 3| 3| 3| 7| 6|
| 4| 4| 1| 2| 1| 4| 4| 4| 2| 1| 5| 5| 5| 6| 8| 5| 5| 2| 1| 1| 6| 6| 6| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hyperplasia | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Pigmentation | |
Pancreatic, Hyperplasia | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + I + + + M + + + + + + + + + + + + + + + +|
Hemorrhage | 1 3 2 3 |
Infiltration Cellular, Histiocyte | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Depletion Lymphoid | |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 2 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
Pigmentation | 1 1 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 4 2 |
Hyperplasia | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Thymus | + + + + + I M + + + + + + + + + M + + + + + M + +|
Congestion | |
Cyst | 1 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Galactocele | |
Hyperplasia | 2 3 2 2 2 2 2 3 2 3 2 2 3 3 2 1|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 |
Sternum, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 2| 7| 7| 7| 4| 2| 7| 7| 7| 6| 2| 7| 7| 4| 2| 2| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 0| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| 0| 6| 3| 3| 6| 8| 8| 3| 3| 3| 7| 6|
| 4| 4| 1| 2| 1| 4| 4| 4| 2| 1| 5| 5| 5| 6| 8| 5| 5| 2| 1| 1| 6| 6| 6| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Autolysis | |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | |
Alveolus, Mineralization | |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Bronchiole, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic Active | 1 |
Metaplasia, Squamous | |
Submucosa, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | M M M M |
__________________________________________________________________________|
Eye | + + + + + |
Synechia | |
Lens, Cataract | 4 |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | |
Autolysis | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hydronephrosis | 4 2 |
Inflammation, Chronic | 1 |
Mineralization | 1 1 |
Nephropathy | 2 1 1 1 2 2 2 2 2 2 2 2 1 2 3 1 2 2 2 1 2|
Pelvis, Inflammation, Chronic Active | |
Renal Tubule, Hyperplasia | 3 |
Renal Tubule, Inflammation, Acute | |
Renal Tubule, Mineralization | |
Renal Tubule, Regeneration | 1 1 |
Transitional Epithelium, Hyperplasia | 1 1 1 1 |
Transitional Epithelium, | |
Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 1 1 1 1 |
Inflammation, Chronic Active | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 7| 7| 6| 4| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 3| 0| 7| 3| 3| 5| 6| 7| 3| 3| 5| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8|
| 6| 6| 6| 4| 9| 6| 6| 6| 2| 9| 4| 1| 8| 2| 1| 4| 4| 5| 5| 9| 4| 4| 4| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Parasite Metazoan | 1 1 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Parasite Metazoan | 2 1 1 1|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + M + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Autolysis | |
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | 1 1 2 4 2 1 1 1 1 1 1 2 2 1 2 1 1 |
Clear Cell Focus | 2 |
Eosinophilic Focus | 1 2 1 |
Fatty Change | 2 2 2 |
Hepatodiaphragmatic Nodule | X |
Hepatodiaphragmatic Nodule, Multiple | |
Infarct | 4 |
Inflammation, Chronic, Granulomatous | |
Inflammation, Chronic Active | 1 2 1 1 1 1 1 2 1 1|
Mixed Cell Focus | 3 |
Necrosis, Coagulative | 1 2 |
Pigmentation | 1 |
Thrombosis | |
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 |
Centrilobular, Hemorrhage | |
Centrilobular, Necrosis, Coagulative | |
Periportal, Inflammation, Chronic | 1 |
Periportal, Inflammation, Chronic | |
Active | 2 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | |
Fibrosis | |
Inflammation, Chronic Active | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 7| 7| 6| 4| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 3| 0| 7| 3| 3| 5| 6| 7| 3| 3| 5| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8|
| 6| 6| 6| 4| 9| 6| 6| 6| 2| 9| 4| 1| 8| 2| 1| 4| 4| 5| 5| 9| 4| 4| 4| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Atrophy | 1 1 1 1 2 1 1 |
Autolysis | |
Ectopic Tissue | X |
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 |
Vacuolization Cytoplasmic | 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sublingual Gland, Inflammation, | |
Chronic Active | |
Submandibular Gland, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell | 1 |
Hyperplasia, Squamous | 2 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 2 1 |
Necrosis, Coagulative | |
Muscularis, Mineralization | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 2 2 1 1 2 1 1 1 1 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + M +|
Angiectasis | 2 1 2 1 2 1 1 1 1 |
Autolysis | |
Hyperplasia | 3 |
Hypertrophy | |
Necrosis, Coagulative | |
Thrombosis, Multiple | |
Vacuolization Cytoplasmic | 3 1 2 1 1 1 |
Capsule, Fibrosis | 1 |
Capsule, Hyperplasia | 1 |
Capsule, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +|
Autolysis | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 7| 7| 6| 4| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 3| 0| 7| 3| 3| 5| 6| 7| 3| 3| 5| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8|
| 6| 6| 6| 4| 9| 6| 6| 6| 2| 9| 4| 1| 8| 2| 1| 4| 4| 5| 5| 9| 4| 4| 4| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
Autolysis | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + M + + M + + + + M + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
Pars Distalis, Cyst | 1 1 2 1 1 2 1 2 1 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 2 1 2 2 1 1 |
Pars Intermedia, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Infiltration Cellular, Mononuclear | |
Cell | |
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 1 1 1 1 1 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Cyst | |
Infiltration Cellular, Mononuclear | |
Cell | |
Inflammation, Chronic | 2 1 1 |
Inflammation, Chronic Active | 1 1 2 2 1 2 1 1 2 1 1 1 3 1 1 1|
Duct, Metaplasia, Squamous | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Fibrosis | 2 3 3 |
Hydrometra | 1 |
Inflammation, Acute | |
Endometrium, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Lymph Node | + + M M + +|
Mediastinal, Hemorrhage | 1 2|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 7| 7| 6| 4| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 3| 0| 7| 3| 3| 5| 6| 7| 3| 3| 5| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8|
| 6| 6| 6| 4| 9| 6| 6| 6| 2| 9| 4| 1| 8| 2| 1| 4| 4| 5| 5| 9| 4| 4| 4| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hyperplasia | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 1 |
Mediastinal, Pigmentation | |
Pancreatic, Hyperplasia | 2 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 4|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Depletion Lymphoid | 3 |
Infiltration Cellular, Histiocyte | 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 4 3 |
Hyperplasia | 3 |
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + M + + + + + + + + + + + +|
Congestion | |
Cyst | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + M + + + + + + + +|
Galactocele | |
Hyperplasia | 4 2 2 2 2 2 2 3 2 2 2 2 2 2 3 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
Sternum, Osteopetrosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 7| 7| 6| 4| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 3| 0| 7| 3| 3| 5| 6| 7| 3| 3| 5| 4| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 8|
| 6| 6| 6| 4| 9| 6| 6| 6| 2| 9| 4| 1| 8| 2| 1| 4| 4| 5| 5| 9| 4| 4| 4| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Autolysis | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 2 3 1 |
Alveolus, Mineralization | |
Artery, Mineralization | 1 1 1 1 1 1 |
Bronchiole, Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic Active | 1 3 1 2 2 2 |
Metaplasia, Squamous | 1 |
Submucosa, Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | M M M|
__________________________________________________________________________|
Eye | + + M + + + + |
Synechia | |
Lens, Cataract | |
Retina, Degeneration | 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
Autolysis | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hydronephrosis | 2 |
Inflammation, Chronic | 1|
Mineralization | |
Nephropathy | 3 1 1 2 2 2 3 3 2 3 2 2 3 2 2 1 2 1 1 2 3 |
Pelvis, Inflammation, Chronic Active | 3 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Inflammation, Acute | |
Renal Tubule, Mineralization | |
Renal Tubule, Regeneration | 1|
Transitional Epithelium, Hyperplasia | 1 1 2 1 2 |
Transitional Epithelium, | |
Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 2 1 2 1 1 1 |
Inflammation, Chronic Active | 1 |
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 2| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 2| | |
DAY ON TEST | 3| 0| 6| 6| 8| 3| 3| 2| 6| 6| 3| 3| 3| 1| 6| 3| 3| 3| 3| 7| | |
| 4| 8| 2| 2| 1| 6| 5| 0| 4| 2| 6| 6| 6| 6| 2| 6| 6| 5| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + M + + + + + + | 69 |
Autolysis | 2 | 3 2.7|
Parasite Metazoan | 1 1 2 2 1 1 1 | 18 1.2|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 69 |
Autolysis | 1 3 | 4 2.5|
Parasite Metazoan | 2 2 1 | 12 1.4|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | 3 3 | 4 2.8|
Parasite Metazoan | 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 68 |
Autolysis | 2 4 | 3 3.3|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 69 |
Autolysis | 2 3 | 3 3.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | | 1 1.0|
Basophilic Focus | 1 1 2 2 1 1 1 1 1 1 1 1 1 | 48 1.3|
Clear Cell Focus | 1 | 3 1.3|
Eosinophilic Focus | 1 | 9 1.4|
Fatty Change | 1 2 1 | 8 1.9|
Hepatodiaphragmatic Nodule | X X X X X X | 10 |
Hepatodiaphragmatic Nodule, Multiple | | 1 |
Infarct | | 1 4.0|
Inflammation, Chronic, Granulomatous | 1 1 1 | 6 1.2|
Inflammation, Chronic Active | 1 1 1 1 1 1 | 24 1.1|
Mixed Cell Focus | | 1 3.0|
Necrosis, Coagulative | | 4 1.3|
Pigmentation | | 2 1.0|
Thrombosis | 4 | 1 4.0|
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 1 1 1 1 1 1 | 41 1.1|
Centrilobular, Hemorrhage | 3 | 1 3.0|
Centrilobular, Necrosis, Coagulative | 3 | 1 3.0|
Periportal, Inflammation, Chronic | 1 1 1 1 1 | 10 1.0|
Periportal, Inflammation, Chronic | | |
Active | 1 1 1 1 1 1 1 | 31 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 2| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 2| | |
DAY ON TEST | 3| 0| 6| 6| 8| 3| 3| 2| 6| 6| 3| 3| 3| 1| 6| 3| 3| 3| 3| 7| | |
| 4| 8| 2| 2| 1| 6| 5| 0| 4| 2| 6| 6| 6| 6| 2| 6| 6| 5| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fibrosis | | 2 1.5|
Inflammation, Chronic Active | | 3 2.7|
Necrosis, Coagulative | 3 | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
Atrophy | 3 2 2 1 1 2 | 22 1.3|
Autolysis | | 1 2.0|
Ectopic Tissue | 1 | 2 1.0|
Infiltration Cellular, Mononuclear | | |
Cell | | 3 1.0|
Inflammation, Chronic | 1 1 1 1 | 9 1.0|
Inflammation, Chronic Active | 2 1 1 1 1 | 29 1.1|
Vacuolization Cytoplasmic | 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
Sublingual Gland, Inflammation, | | |
Chronic Active | | 1 1.0|
Submandibular Gland, Inflammation, | | |
Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + M + + + + + + | 69 |
Autolysis | | 1 2.0|
Hyperkeratosis | | 2 2.0|
Hyperplasia, Basal Cell | | 2 1.0|
Hyperplasia, Squamous | | 2 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | 3 | 2 2.5|
Inflammation, Chronic Active | | 3 1.7|
Necrosis, Coagulative | 1 | 1 1.0|
Muscularis, Mineralization | | 2 1.5|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Cardiomyopathy | 1 1 1 1 1 1 1 2 1 1 1 2 1 2 1 2 1 2 1 | 63 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + M + + | 67 |
Angiectasis | 1 1 2 1 2 1 1 2 2 1 1 | 30 1.4|
Autolysis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 2| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 2| | |
DAY ON TEST | 3| 0| 6| 6| 8| 3| 3| 2| 6| 6| 3| 3| 3| 1| 6| 3| 3| 3| 3| 7| | |
| 4| 8| 2| 2| 1| 6| 5| 0| 4| 2| 6| 6| 6| 6| 2| 6| 6| 5| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 3 2.0|
Hypertrophy | | 1 3.0|
Necrosis, Coagulative | 3 | 1 3.0|
Thrombosis, Multiple | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 1 3 1 3 | 17 1.9|
Capsule, Fibrosis | | 1 1.0|
Capsule, Hyperplasia | | 1 1.0|
Capsule, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + M + + | 67 |
Autolysis | 2 | 1 2.0|
Hyperplasia | 3 | 11 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + | 50 |
Autolysis | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + | 63 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Thrombosis | | 1 4.0|
Pars Distalis, Cyst | 1 1 1 1 1 1 | 24 1.2|
Pars Distalis, Hemorrhage | | 1 1.0|
Pars Distalis, Hyperplasia | 2 1 2 | 14 1.6|
Pars Intermedia, Cyst | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | 2 | 2 2.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 1 1.0|
Ultimobranchial Cyst | | 1 2.0|
C-Cell, Hyperplasia | 1 1 2 | 11 1.1|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + + + | 65 |
Abscess | | 2 2.5|
Cyst | | 1 4.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 1 1.0|
Inflammation, Chronic | 1 1 1 | 10 1.3|
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 1 | 37 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 2| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 2| | |
DAY ON TEST | 3| 0| 6| 6| 8| 3| 3| 2| 6| 6| 3| 3| 3| 1| 6| 3| 3| 3| 3| 7| | |
| 4| 8| 2| 2| 1| 6| 5| 0| 4| 2| 6| 6| 6| 6| 2| 6| 6| 5| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Duct, Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst | 1 1 1 1 | 11 1.8|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst | | 1 1.0|
Fibrosis | | 3 2.7|
Hydrometra | 3 2 2 1 | 8 2.1|
Inflammation, Acute | | 1 1.0|
Endometrium, Hyperplasia | 2 | 5 1.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + M | 7 |
Mediastinal, Hemorrhage | 1 1 | 4 1.3|
Mediastinal, Hyperplasia | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Mediastinal, Pigmentation | 1 | 1 1.0|
Pancreatic, Hyperplasia | | 2 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 3 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + M + + + + + | 66 |
Hemorrhage | 1 1 | 8 2.1|
Infiltration Cellular, Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | 2 | 1 2.0|
Depletion Lymphoid | 2 | 2 2.5|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 | 69 1.1|
Pigmentation | 1 1 1 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Depletion Lymphoid | 3 3 3 2 | 8 3.0|
Hyperplasia | | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + M + + + + + + | 62 |
Congestion | 2 | 1 2.0|
Cyst | | 1 1.0|
Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 2| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 2| | |
DAY ON TEST | 3| 0| 6| 6| 8| 3| 3| 2| 6| 6| 3| 3| 3| 1| 6| 3| 3| 3| 3| 7| | |
| 4| 8| 2| 2| 1| 6| 5| 0| 4| 2| 6| 6| 6| 6| 2| 6| 6| 5| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + + + + + M + + + + + | 65 |
Galactocele | 1 | 1 1.0|
Hyperplasia | 2 3 2 2 2 2 2 2 1 2 2 3 2 3 1 | 47 2.2|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Abscess | 3 | 1 3.0|
Inflammation, Chronic Active | | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Osteopetrosis | | 1 2.0|
Sternum, Osteopetrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Hydrocephalus | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | 2 | 1 2.0|
Hemorrhage | | 1 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 3 1 1 1 1 1 | 38 1.1|
Inflammation, Chronic Active | 2 | 4 2.0|
Alveolus, Mineralization | 1 | 1 1.0|
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 | 31 1.0|
Bronchiole, Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Foreign Body | | 1 2.0|
Inflammation, Chronic Active | 3 1 | 9 1.8|
Metaplasia, Squamous | | 1 1.0|
Submucosa, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | M M | |
__________________________________________________________________________|____________|
Eye | + + | 13 |
Synechia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 2| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 2| | |
DAY ON TEST | 3| 0| 6| 6| 8| 3| 3| 2| 6| 6| 3| 3| 3| 1| 6| 3| 3| 3| 3| 7| | |
| 4| 8| 2| 2| 1| 6| 5| 0| 4| 2| 6| 6| 6| 6| 2| 6| 6| 5| 5| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
D 71UF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Lens, Cataract | | 1 4.0|
Retina, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Autolysis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | 2 3 | 2 2.5|
Hydronephrosis | | 3 2.7|
Inflammation, Chronic | 1 1 | 4 1.0|
Mineralization | 1 | 3 1.0|
Nephropathy | 3 1 1 3 2 2 2 1 2 1 2 1 1 1 2 2 2 2 | 60 1.9|
Pelvis, Inflammation, Chronic Active | | 1 3.0|
Renal Tubule, Hyperplasia | | 1 3.0|
Renal Tubule, Inflammation, Acute | 1 | 1 1.0|
Renal Tubule, Mineralization | 1 | 1 1.0|
Renal Tubule, Regeneration | 1 | 4 1.0|
Transitional Epithelium, Hyperplasia | 1 1 1 1 | 13 1.2|
Transitional Epithelium, | | |
Mineralization | 1 | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | 3 | 1 3.0|
Hyperplasia, Lymphoid | 1 1 1 1 1 | 15 1.1|
Inflammation, Chronic Active | | 1 1.0|
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| 7| 2| 2| 7| 7| 7| 7| 6| 7| 6| 6| 2| 2|
DAY ON TEST | 3| 3| 1| 0| 8| 3| 3| 3| 1| 8| 3| 3| 3| 8| 8| 3| 3| 3| 3| 5| 3| 8| 6| 8| 8|
| 4| 4| 6| 0| 1| 4| 4| 4| 1| 1| 4| 4| 4| 1| 1| 4| 4| 0| 0| 9| 4| 9| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.2% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 2 2 1 1 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 1 |
Fibrosis | |
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hemorrhage | |
Parasite Metazoan | 1 2 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | 1 1 2 1 1 |
Clear Cell Focus | 1 1 2 1 2 1 1 2 1 1 2 1 1 2 |
Eosinophilic Focus | 2 2 1 4 1 3 2 1 1 2 1 2 1 2 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | |
Inflammation, Chronic Active | 1 2 1 1 2 1 1 1 2 |
Mixed Cell Focus | 2 4 1 2 |
Necrosis, Coagulative | 1 1 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1|
Bile Duct, Hyperplasia | 1 1 1 1 1 |
Periportal, Inflammation, Chronic | |
Active | 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | M + M M M M M|
Fibrosis | 2 |
Inflammation, Chronic Active | 2 |
Necrosis, Coagulative | 3 |
Polyarteritis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 2 1 2 2 1 2 1 |
Cytoplasmic Alteration | 2 |
Ectopic Tissue | 1 |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1|
Inflammation, Chronic Active | 1 2 1 1 1 1 1 1 1 1 |
Polyarteritis | 4 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| 7| 2| 2| 7| 7| 7| 7| 6| 7| 6| 6| 2| 2|
DAY ON TEST | 3| 3| 1| 0| 8| 3| 3| 3| 1| 8| 3| 3| 3| 8| 8| 3| 3| 3| 3| 5| 3| 8| 6| 8| 8|
| 4| 4| 6| 0| 1| 4| 4| 4| 1| 1| 4| 4| 4| 1| 1| 4| 4| 0| 0| 9| 4| 9| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.2% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 2 2 |
Hyperplasia, Basal Cell | 1 2 3 |
Hyperplasia, Squamous | 2 2 3 |
Inflammation, Chronic Active | 2 |
Ulcer | 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Tooth | |
Cyst | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1 1 1 1 1 2 1 2 1 1 1 2 2 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 2 1 2 2 2 1 1 2 2 1 2 2 |
Hyperplasia | 1 1 1 |
Vacuolization Cytoplasmic | 1 1 1 1 2 1 1 1 1 1 |
Zona Reticularis, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 1|
Pars Distalis, Cyst | 1 1 1 2 2 1 1 1 |
Pars Distalis, Hyperplasia | 1 2 1 1 1 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Hyperplasia | 2 |
Inflammation, Chronic Active | 1 1 2 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| 7| 2| 2| 7| 7| 7| 7| 6| 7| 6| 6| 2| 2|
DAY ON TEST | 3| 3| 1| 0| 8| 3| 3| 3| 1| 8| 3| 3| 3| 8| 8| 3| 3| 3| 3| 5| 3| 8| 6| 8| 8|
| 4| 4| 6| 0| 1| 4| 4| 4| 1| 1| 4| 4| 4| 1| 1| 4| 4| 0| 0| 9| 4| 9| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.2% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 2 2 |
Pigmentation | |
Periovarian Tissue, Cyst | 2 2 2|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 3 |
Cyst | 3 |
Hydrometra | 1 1 3 |
Endometrium, Hyperplasia | 2 2 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Mediastinal, Hemorrhage | 1 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 1 |
Mediastinal, Pigmentation | |
Pancreatic, Depletion Lymphoid | 2 |
Pancreatic, Hemorrhage | 2 1 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 2 1 1 2 |
Pancreatic, Pigmentation | 1 1 |
Renal, Hemorrhage | 1 |
Renal, Infiltration Cellular, | |
Histiocyte | 3 |
Renal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 |
Hyperplasia | 2 |
Infiltration Cellular, Histiocyte | 1 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
Pigmentation | 1 1 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | 1 |
__________________________________________________________________________|
Thymus | + + + M + M + + + + + M + + + + + + + + M + M + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| 7| 2| 2| 7| 7| 7| 7| 6| 7| 6| 6| 2| 2|
DAY ON TEST | 3| 3| 1| 0| 8| 3| 3| 3| 1| 8| 3| 3| 3| 8| 8| 3| 3| 3| 3| 5| 3| 8| 6| 8| 8|
| 4| 4| 6| 0| 1| 4| 4| 4| 1| 1| 4| 4| 4| 1| 1| 4| 4| 0| 0| 9| 4| 9| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.2% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + M + + + + + + M M + + + + + + + + M M|
Hyperplasia | 2 2 2 2 1 2 2 3 1 1 1 1 2 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foot, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Artery, Mineralization | 1 1 1 1 1 1 1 |
Mediastinum, Polyarteritis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 2 3 |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Phthisis Bulbi | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Infarct | 3 |
Infiltration Cellular | |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 1|
Mineralization | 1 |
Nephropathy | 3 2 3 4 2 3 3 4 2 2 2 2 4 4 2 2 2 1 |
Polyarteritis | 2 |
Pelvis, Inflammation, Chronic Active | |
Renal Tubule, Hyperplasia | 4 3 2 3 3 3 |
Renal Tubule, Inflammation, Acute | 1 1 1 |
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 1 1 2 2 1 1 2 2 2 2 2 2 2 2 2 2|
Renal Tubule, Regeneration | 1 1 |
Transitional Epithelium, Hyperplasia | 3 2 1 2 1 1 2 |
Transitional Epithelium, | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 7| 7| 7| 2| 2| 7| 7| 7| 7| 6| 7| 6| 6| 2| 2|
DAY ON TEST | 3| 3| 1| 0| 8| 3| 3| 3| 1| 8| 3| 3| 3| 8| 8| 3| 3| 3| 3| 5| 3| 8| 6| 8| 8|
| 4| 4| 6| 0| 1| 4| 4| 4| 1| 1| 4| 4| 4| 1| 1| 4| 4| 0| 0| 9| 4| 9| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.2% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | 2 |
Transitional Epithelium, Hyperplasia | 3 |
Transitional Epithelium, Metaplasia, | |
Squamous | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 2| 2| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| |
DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| |
| 4| 4| 4| 1| 1| 4| 4| 3| 0| 9| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0.2% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| L |
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 1 2 2 1 1 1 | 13 1.3|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | | 1 1.0|
Fibrosis | 2 | 1 2.0|
Parasite Metazoan | 2 1 1 | 4 1.5|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Autolysis | 3 | 1 3.0|
Hemorrhage | 1 | 1 1.0|
Parasite Metazoan | 1 1 1 1 | 7 1.1|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Autolysis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Autolysis | 3 | 1 3.0|
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Basophilic Focus | 1 3 1 2 1 3 2 1 3 1 | 15 1.6|
Clear Cell Focus | 1 2 2 2 3 1 2 2 2 2 1 1 2 2 | 28 1.6|
Eosinophilic Focus | 2 2 3 3 3 2 2 3 2 | 23 2.0|
Hepatodiaphragmatic Nodule | X X X | 4 |
Hyperplasia, Focal | 3 | 1 3.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 | 16 1.2|
Mixed Cell Focus | 2 2 1 2 2 1 2 | 11 1.9|
Necrosis, Coagulative | 3 1 | 4 1.5|
Pigmentation | 1 1 1 1 1 2 1 1 1 1 | 21 1.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 | 10 1.0|
Periportal, Inflammation, Chronic | | |
Active | 1 1 1 1| 12 1.0|
__________________________________________________________________________|____________|
Mesentery | M M M + + + + + M| 6 |
Fibrosis | 2 2 2 2 | 5 2.0|
Inflammation, Chronic Active | 1 2 | 3 1.7|
Necrosis, Coagulative | 2 2 2 3 | 5 2.4|
Polyarteritis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 2 1 1 3 2 3 | 19 1.6|
Cytoplasmic Alteration | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 2| 2| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| |
DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| |
| 4| 4| 4| 1| 1| 4| 4| 3| 0| 9| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0.2% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| L |
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ectopic Tissue | | 1 1.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 | 7 1.0|
Inflammation, Chronic Active | 1 1 2 1 1 1 1 1 1 2 1 1 1 1 | 24 1.1|
Polyarteritis | 3 | 2 3.5|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 1 2 1 1 | 7 1.4|
Hyperplasia, Basal Cell | 1 2 1 1 | 7 1.6|
Hyperplasia, Squamous | 1 3 1 1 | 7 1.9|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Cyst | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 1 1 2 1 2 1 2 2 2 2 2 1 2 2 2 1 2 1 1 1| 46 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 1 2 1 1 2 1 3 2 1 1 2 2 1 1 1 | 32 1.5|
Hyperplasia | 1 | 4 1.0|
Vacuolization Cytoplasmic | 1 1 1 1 2 1 | 16 1.1|
Zona Reticularis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 5 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + | 40 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + M + + + + + +| 47 |
Hyperplasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 2 | 3 1.3|
Pars Distalis, Cyst | 1 2 1 3 1 2 1 1 1 2 2 1 3 | 21 1.5|
Pars Distalis, Hyperplasia | 2 2 | 10 1.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 2| 2| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| |
DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| |
| 4| 4| 4| 1| 1| 4| 4| 3| 0| 9| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0.2% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| L |
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + M + + + + + M + + + + + M + + + + + + + + + +| 46 |
Cyst | | 1 1.0|
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1| 21 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 3 2.7|
Pigmentation | 2| 1 2.0|
Periovarian Tissue, Cyst | 1 | 4 1.8|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 2 2 2 2 | 6 2.2|
Cyst | 3 4 3 4 | 5 3.4|
Hydrometra | 1 2 2 | 6 1.7|
Endometrium, Hyperplasia | 1 1 2 1 2 | 9 1.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + M| 11 |
Mediastinal, Hemorrhage | | 1 1.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Mediastinal, Pigmentation | 1 | 1 1.0|
Pancreatic, Depletion Lymphoid | | 1 2.0|
Pancreatic, Hemorrhage | | 2 1.5|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 2 1 2 | 8 1.6|
Pancreatic, Pigmentation | 1 | 3 1.0|
Renal, Hemorrhage | | 1 1.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Renal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 2| 2| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| |
DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| |
| 4| 4| 4| 1| 1| 4| 4| 3| 0| 9| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0.2% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| L |
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 | 2 1.0|
Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | | 1 3.0|
Hemorrhage | 1 2 | 4 1.3|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 49 1.1|
Pigmentation | 1 1 1| 7 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | 2 | 1 2.0|
Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | M + M + + + + M M + + + + + + + + + + + + + + + +| 41 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + M + + + + + + M M + + + + + + M + + + + M +| 38 |
Hyperplasia | 2 3 2 2 2 1 2 2 2 2 1 1 | 29 1.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Foot, Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 33 1.0|
Artery, Mineralization | 1 1| 9 1.0|
Mediastinum, Polyarteritis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 1 4 3 2 | 8 2.5|
Metaplasia, Squamous | 1 2 1 | 4 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 2| 2| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| |
DAY ON TEST | 3| 3| 3| 8| 8| 3| 3| 3| 7| 7| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| |
| 4| 4| 4| 1| 1| 4| 4| 3| 0| 9| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
0.2% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| L |
71LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 7 |
Phthisis Bulbi | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Infarct | | 1 3.0|
Infiltration Cellular | 1 | 1 1.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 | 9 1.0|
Mineralization | | 1 1.0|
Nephropathy | 3 3 4 3 2 3 2 3 3 2 2 1 3 2 3 3 2 2 2 3 2 | 39 2.6|
Polyarteritis | | 1 2.0|
Pelvis, Inflammation, Chronic Active | 2 | 1 2.0|
Renal Tubule, Hyperplasia | 3 3 1 2 1 2 | 12 2.5|
Renal Tubule, Inflammation, Acute | 1 1 1 1 | 7 1.0|
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 50 1.9|
Renal Tubule, Regeneration | 1 1 1| 5 1.0|
Transitional Epithelium, Hyperplasia | 2 1 3 3 1 1 3 1 1 | 16 1.8|
Transitional Epithelium, | | |
Mineralization | 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Gross Observation | X | 2 |
Hyperplasia, Lymphoid | 1 1 | 2 1.0|
Inflammation, Chronic Active | | 1 2.0|
Transitional Epithelium, Hyperplasia | 3 | 2 3.0|
Transitional Epithelium, Metaplasia, | | |
Squamous | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 6| 2|
DAY ON TEST | 2| 2| 2| 2| 6| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 3| 3| 3| 1| 7| 3| 3| 3| 4| 8|
| 9| 9| 9| 9| 7| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71MLF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + M + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 |
Parasite Metazoan | 2 1 1 2 1 1|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 1 1 |
Autolysis | 3 3 |
Parasite Metazoan | 1 1 1 1 |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 3 |
Mineralization | 1 |
Parasite Metazoan | 2 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + M + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + M + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 1 |
Basophilic Focus | 1 1 4 1 4 2 2 1 2 1 1 |
Clear Cell Focus | 1 1 2 4 1 2 2 2 2 2 1 3 |
Degeneration | |
Eosinophilic Focus | 1 1 2 2 3 3 3 4 |
Fatty Change | 1 |
Hematopoietic Cell Proliferation | 1 2 1 1 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic Active | 1 1 1 2 1 1 1 1 1 |
Mixed Cell Focus | 1 1 1 1 |
Necrosis, Coagulative | |
Pigmentation | 1 1 1 2 1 2 2 1 1 1 2 1 1 2 1 1 2 2 2 2 1|
Bile Duct, Hyperplasia | 1 1 2 2 2 1 2 2 1 1 3 2 2 2 1 2 2 2 1 1 2 2 2 2 |
Periportal, Inflammation, Chronic | |
Active | 1 1 1 2 1 2 2 1 1 1 2 2 2 1 2 2 2 1 1 2 2 2 2 1|
__________________________________________________________________________|
Mesentery | |
Fibrosis | |
Inflammation, Chronic Active | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 1 1 1 1 2 |
Autolysis | |
Cytoplasmic Alteration | 1 |
Ectopic Liver | X |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 6| 2|
DAY ON TEST | 2| 2| 2| 2| 6| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 3| 3| 3| 1| 7| 3| 3| 3| 4| 8|
| 9| 9| 9| 9| 7| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71MLF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Infiltration Cellular, Mixed Cell | 2|
Inflammation, Chronic Active | 2 1 1 1 1 1 1 1 1 1 1 1 1 |
Vacuolization Cytoplasmic | 2 1 1 1 1 1 |
Acinus, Hyperplasia | 2 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Parotid Gland, Inflammation, Chronic | |
Active | 1 |
Submandibular Gland, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperkeratosis | 2 2 2 2 1 |
Hyperplasia, Basal Cell | 1 1 1 2 2 2 2 2 2 2 1 |
Hyperplasia, Squamous | 2 4 4 2 2 3 2 3 |
Inflammation, Chronic Active | 2 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 |
Fibrosis | |
Inflammation, Chronic Active | 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 2 1 2 2 1 1 1 |
Hyperplasia | 1 |
Vacuolization Cytoplasmic | 1 1 2 1 1 3 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + M + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Autolysis | 2 |
Pars Distalis, Cyst | 1 2 1 1 2 1 |
Pars Distalis, Hyperplasia | 1 2 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 6| 2|
DAY ON TEST | 2| 2| 2| 2| 6| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 3| 3| 3| 1| 7| 3| 3| 3| 4| 8|
| 9| 9| 9| 9| 7| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71MLF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Pars Intermedia, Cyst | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 1 |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | |
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Abscess | 2 2 |
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 1 |
Periovarian Tissue, Cyst | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 3 |
Decidual Reaction | |
Fibrosis | 2 |
Hydrometra | 2 2 1 3 |
Endometrium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + M M + + + M|
Mediastinal, Hemorrhage | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 1 1 |
Mediastinal, Pigmentation | 1 |
Pancreatic, Hemorrhage | |
Pancreatic, Hyperplasia | 2 2 3 2 1 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 2 1 2 1 2 2 2 1 |
Pancreatic, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 2 |
Hyperplasia | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 6| 2|
DAY ON TEST | 2| 2| 2| 2| 6| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 3| 3| 3| 1| 7| 3| 3| 3| 4| 8|
| 9| 9| 9| 9| 7| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71MLF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Depletion Lymphoid | 3 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 1 2 1 1 2 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 2|
Pigmentation | 1 1 1 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + M + + + + + +|
Depletion Lymphoid | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M M + M + + M M + M + M + + + + +|
Hyperplasia | 1 1 1 1 2 2 2 1 1 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Foreign Body | |
Inflammation, Chronic Active | 1 1 |
Foot, Acanthosis | |
Foot, Hyperkeratosis | |
Foot, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 |
Alveolar Epithelium, Hyperplasia | |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic Active | 3 3 2 |
Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 7| 2| 7| 7| 7| 6| 2|
DAY ON TEST | 2| 2| 2| 2| 6| 2| 2| 2| 2| 8| 2| 2| 2| 2| 7| 3| 3| 3| 1| 7| 3| 3| 3| 4| 8|
| 9| 9| 9| 9| 7| 9| 9| 9| 9| 1| 9| 9| 9| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71MLF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Ear | + + |
External Ear, Inflammation, Acute | 3 |
Internal Ear, Inflammation, Acute | 3 |
__________________________________________________________________________|
Eye | + + |
Phthisis Bulbi | 4 |
Lens, Cataract | |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Autolysis | |
Cyst | 2 |
Fibrosis | |
Hydronephrosis | 2 |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1|
Inflammation, Chronic Active | 2 |
Nephropathy | 2 3 2 4 2 3 3 3 4 2 3 2 2 2 3 2 3 3 2 2 2 |
Pigmentation | |
Artery, Thrombosis | 4 |
Pelvis, Inflammation, Chronic Active | 3 |
Pelvis, Metaplasia, Squamous | 4 |
Renal Tubule, Hyperplasia | 1 3 3 4 2 2 4 3 2 2 |
Renal Tubule, Hyperplasia, Oncocytic | 4 |
Renal Tubule, Inflammation, Acute | 1 1 1 |
Renal Tubule, Inflammation, Chronic | |
Active | |
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Renal Tubule, Regeneration | 1 1 |
Transitional Epithelium, Hyperplasia | 1 4 2 1 1 2 1 3 1 2 2 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Fibrosis | |
Hyperplasia, Lymphoid | 1 |
Inflammation, Chronic Active | 1 1 |
Fat, Proliferation | 2 2 |
Transitional Epithelium, Hyperplasia | 2 2 1 2 2 2 1 2 1 2 1 1 2 1 1 2 2 |
Transitional Epithelium, Metaplasia, | |
Squamous | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 7| 7| 6| 6| 6| 7| 6| 5| 2| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 1| 8| 3| 3| 9| 7| 0| 3| 9| 8| 8| 7| 3| 3| 6| 4| 7| 3| 3| 3| 3| 3|
| 0| 0| 0| 6| 1| 0| 0| 6| 0| 6| 0| 1| 2| 1| 9| 0| 0| 0| 2| 9| 0| 0| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71MLF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 3 3 4 |
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 1 2 1 |
Autolysis | 2 2 3 2 |
Parasite Metazoan | 1 1 1 1 |
Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 3 4 4 |
Mineralization | |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 1 1 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 4 2 1 1 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 3 4 2 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 2 |
Basophilic Focus | 2 1 2 2 2 2 2 1 1 |
Clear Cell Focus | 2 2 2 2 2 2 2 4 2 3 2 3 2 2 2 |
Degeneration | 1 1 1 |
Eosinophilic Focus | 4 |
Fatty Change | 3|
Hematopoietic Cell Proliferation | 1 1 |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic Active | 2 1 1 1 2 1 1 |
Mixed Cell Focus | 2 |
Necrosis, Coagulative | 1 1 1 1 1 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 2 1 1 1 |
Bile Duct, Hyperplasia | 2 2 2 1 1 2 2 2 2 2 1 2 1 1 2 2 2 1 3 2 2 1 2|
Periportal, Inflammation, Chronic | |
Active | 2 2 2 1 2 2 2 3 2 1 2 1 1 1 1 2 1 2 2 2 1 1|
__________________________________________________________________________|
Mesentery | |
Fibrosis | |
Inflammation, Chronic Active | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 1 2 2 |
Autolysis | 2 |
Cytoplasmic Alteration | |
Ectopic Liver | X |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 7| 7| 6| 6| 6| 7| 6| 5| 2| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 1| 8| 3| 3| 9| 7| 0| 3| 9| 8| 8| 7| 3| 3| 6| 4| 7| 3| 3| 3| 3| 3|
| 0| 0| 0| 6| 1| 0| 0| 6| 0| 6| 0| 1| 2| 1| 9| 0| 0| 0| 2| 9| 0| 0| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71MLF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Infiltration Cellular, Mononuclear | |
Cell | |
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic Active | 1 2 2 1 1 1 1 1 |
Vacuolization Cytoplasmic | 1 1 2 1 |
Acinus, Hyperplasia | |
Duct, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Parotid Gland, Inflammation, Chronic | |
Active | 1 |
Submandibular Gland, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 3|
Hyperkeratosis | 3 2 3 3 2 1 2|
Hyperplasia, Basal Cell | 4 2 1 1 4 3 1 1 2 2|
Hyperplasia, Squamous | 2 4 3 3 3 3 3|
Inflammation, Chronic Active | 2 3 3 1 2|
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 2 |
Fibrosis | 1 |
Inflammation, Chronic Active | 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + M + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 2 1 2 2 1 1 2 1 2 1 1 |
Hyperplasia | 1 1 |
Vacuolization Cytoplasmic | 1 3 1 2 1 1 1 2 1 1 3 |
__________________________________________________________________________|
Adrenal Medulla | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Autolysis | 2 |
Pars Distalis, Cyst | 1 1 2 1 2 1 1 1 |
Pars Distalis, Hyperplasia | 1 2 1 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 7| 7| 6| 6| 6| 7| 6| 5| 2| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 1| 8| 3| 3| 9| 7| 0| 3| 9| 8| 8| 7| 3| 3| 6| 4| 7| 3| 3| 3| 3| 3|
| 0| 0| 0| 6| 1| 0| 0| 6| 0| 6| 0| 1| 2| 1| 9| 0| 0| 0| 2| 9| 0| 0| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71MLF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Pars Intermedia, Cyst | 1 1 |
Pars Intermedia, Cyst | 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic Active | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Periovarian Tissue, Cyst | 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 3 4 |
Decidual Reaction | 3 |
Fibrosis | |
Hydrometra | 1 2 2 2 |
Endometrium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + M + + + M + + |
Mediastinal, Hemorrhage | 1 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Pigmentation | 1 |
Pancreatic, Hemorrhage | 2 |
Pancreatic, Hyperplasia | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 3 1 2 2 2 3 |
Pancreatic, Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + M|
Hemorrhage | 1 1 |
Hyperplasia | 2 |
Infiltration Cellular, Histiocyte | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 7| 7| 6| 6| 6| 7| 6| 5| 2| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 1| 8| 3| 3| 9| 7| 0| 3| 9| 8| 8| 7| 3| 3| 6| 4| 7| 3| 3| 3| 3| 3|
| 0| 0| 0| 6| 1| 0| 0| 6| 0| 6| 0| 1| 2| 1| 9| 0| 0| 0| 2| 9| 0| 0| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71MLF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Depletion Lymphoid | |
Hemorrhage | 1 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 2 1 1 1 2|
Pigmentation | 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 2 |
Fibrosis | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + M + + + + + + + + + + + M|
Depletion Lymphoid | |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + + M + + + + M + + + + + + + + + M M + + + +|
Hyperplasia | 2 2 1 1 2 1 1 2 3 2 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 3 2 |
Foreign Body | |
Inflammation, Chronic Active | 1 |
Foot, Acanthosis | 2 |
Foot, Hyperkeratosis | 2 |
Foot, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 1 |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 1 |
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Chronic Active | 3 1 3 3 1 1 |
Metaplasia, Squamous | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 7| 7| 6| 6| 6| 7| 6| 5| 2| 2| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 1| 8| 3| 3| 9| 7| 0| 3| 9| 8| 8| 7| 3| 3| 6| 4| 7| 3| 3| 3| 3| 3|
| 0| 0| 0| 6| 1| 0| 0| 6| 0| 6| 0| 1| 2| 1| 9| 0| 0| 0| 2| 9| 0| 0| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71MLF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Ear | + + + + + |
External Ear, Inflammation, Acute | 3 |
Internal Ear, Inflammation, Acute | |
__________________________________________________________________________|
Eye | + + + |
Phthisis Bulbi | |
Lens, Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Autolysis | 3 3 2 |
Cyst | 1 |
Fibrosis | |
Hydronephrosis | 2 |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 |
Inflammation, Chronic Active | |
Nephropathy | 2 3 3 2 3 3 3 3 3 3 3 2 3 3 2 2 2 3 3 3 2|
Pigmentation | 2 |
Artery, Thrombosis | |
Pelvis, Inflammation, Chronic Active | 2 2 |
Pelvis, Metaplasia, Squamous | 2 |
Renal Tubule, Hyperplasia | 2 3 1 1 4 |
Renal Tubule, Hyperplasia, Oncocytic | |
Renal Tubule, Inflammation, Acute | |
Renal Tubule, Inflammation, Chronic | |
Active | 1 |
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1|
Renal Tubule, Regeneration | 1 1 1 |
Transitional Epithelium, Hyperplasia | 1 1 1 1 1 3 2 1 1 1 1 1 1 3 3 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 3 |
Fibrosis | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic Active | |
Fat, Proliferation | |
Transitional Epithelium, Hyperplasia | 2 3 2 4 2 3 2 3 2 2 2 1 |
Transitional Epithelium, Metaplasia, | |
Squamous | 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2| | |
DAY ON TEST | 2| 2| 1| 0| 7| 3| 3| 0| 9| 7| 3| 3| 2| 4| 0| 2| 2| 6| 4| 8| | |
| 9| 9| 4| 9| 5| 0| 0| 8| 5| 9| 0| 0| 5| 9| 1| 9| 9| 0| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
71MLF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + M + | 67 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 69 |
Autolysis | | 5 2.8|
Parasite Metazoan | 2 | 9 1.3|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 70 |
Atypia Cellular | 2 | 6 1.3|
Autolysis | | 6 2.5|
Parasite Metazoan | 1 | 9 1.0|
Epithelium, Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | | 6 3.5|
Mineralization | | 1 1.0|
Parasite Metazoan | 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 69 |
Autolysis | | 5 2.2|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 69 |
Autolysis | 1 | 8 2.6|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + M + + + + + + + | 69 |
Autolysis | 3 | 8 3.4|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | | 4 1.5|
Basophilic Focus | 1 1 | 22 1.7|
Clear Cell Focus | 2 2 1 3 1 3 2 1 2 2 2 1 | 39 2.0|
Degeneration | | 3 1.0|
Eosinophilic Focus | 1 3 3 | 12 2.5|
Fatty Change | 3 4 | 4 2.8|
Hematopoietic Cell Proliferation | 1 1 1 | 10 1.1|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 2 1 | 23 1.2|
Mixed Cell Focus | | 5 1.2|
Necrosis, Coagulative | 1 2 1 1 1 1 | 11 1.1|
Pigmentation | 2 2 2 1 2 1 2 1 1 1 2 2 2 1 1 | 57 1.4|
Bile Duct, Hyperplasia | 2 2 2 1 1 2 2 2 1 1 1 1 2 1 2 2 1 1 | 65 1.7|
Periportal, Inflammation, Chronic | | |
Active | 2 2 1 1 1 2 2 2 1 1 1 2 2 1 2 2 1 1 | 64 1.6|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fibrosis | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Necrosis, Coagulative | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2| | |
DAY ON TEST | 2| 2| 1| 0| 7| 3| 3| 0| 9| 7| 3| 3| 2| 4| 0| 2| 2| 6| 4| 8| | |
| 9| 9| 4| 9| 5| 0| 0| 8| 5| 9| 0| 0| 5| 9| 1| 9| 9| 0| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
71MLF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
Atrophy | 1 1 3 1 1 1 | 16 1.7|
Autolysis | | 1 2.0|
Cytoplasmic Alteration | 1 | 2 1.0|
Ectopic Liver | | 2 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 1.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Chronic Active | 1 2 1 2 1 1 1 1 1 | 30 1.2|
Vacuolization Cytoplasmic | 2 1 | 12 1.3|
Acinus, Hyperplasia | | 1 2.0|
Duct, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Parotid Gland, Inflammation, Chronic | | |
Active | | 2 1.0|
Submandibular Gland, Inflammation, | | |
Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
Erosion | | 2 2.5|
Hyperkeratosis | 2 3 2 2 2 2 2 2 2 3 2 | 23 2.1|
Hyperplasia, Basal Cell | 2 1 2 1 2 2 2 1 2 2 2 2 2 2 | 35 1.8|
Hyperplasia, Squamous | 3 4 3 2 3 3 3 3 2 4 3 | 26 2.9|
Inflammation, Chronic Active | 3 2 2 3 2 2 | 13 2.2|
Ulcer | 2 1 1 2 2 1 | 7 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | | 3 1.7|
Fibrosis | | 1 1.0|
Inflammation, Chronic Active | 2 | 6 1.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Cardiomyopathy | 1 1 2 1 2 1 1 1 1 2 1 1 1 1 1 1 | 60 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 69 |
Angiectasis | 2 1 1 2 2 1 1 2 1 2 2 2 1 1 2 1 | 41 1.4|
Hyperplasia | 1 | 4 1.0|
Vacuolization Cytoplasmic | 1 2 1 1 1 1 1 2 1 1 1 | 35 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2| | |
DAY ON TEST | 2| 2| 1| 0| 7| 3| 3| 0| 9| 7| 3| 3| 2| 4| 0| 2| 2| 6| 4| 8| | |
| 9| 9| 4| 9| 5| 0| 0| 8| 5| 9| 0| 0| 5| 9| 1| 9| 9| 0| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
71MLF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 69 |
Hyperplasia | 1 1 2 | 11 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + | 67 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Pars Distalis, Angiectasis | 1 | 1 1.0|
Pars Distalis, Autolysis | | 2 2.0|
Pars Distalis, Cyst | 2 2 2 2 1 1 3 1 1 | 23 1.4|
Pars Distalis, Hyperplasia | 2 2 2 2 | 15 1.5|
Pars Distalis, Pars Intermedia, Cyst | | 2 1.0|
Pars Intermedia, Cyst | | 3 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | | 1 3.0|
Inflammation, Chronic Active | | 1 1.0|
Ultimobranchial Cyst | 1 | 1 1.0|
C-Cell, Hyperplasia | 1 | 3 1.3|
Follicle, Cyst | | 1 2.0|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + M + + + + + + + + + + | 68 |
Abscess | | 3 2.7|
Inflammation, Chronic Active | 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 2 | 51 1.1|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst | 3 2 | 5 2.0|
Periovarian Tissue, Cyst | | 3 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 70 |
Abscess | 2 3 4 | 8 3.3|
Decidual Reaction | | 1 3.0|
Fibrosis | | 1 2.0|
Hydrometra | 2 | 9 1.9|
Endometrium, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2| | |
DAY ON TEST | 2| 2| 1| 0| 7| 3| 3| 0| 9| 7| 3| 3| 2| 4| 0| 2| 2| 6| 4| 8| | |
| 9| 9| 4| 9| 5| 0| 0| 8| 5| 9| 0| 0| 5| 9| 1| 9| 9| 0| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
71MLF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + M + + + M | 28 |
Mediastinal, Hemorrhage | | 3 1.7|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 2 1.0|
Mediastinal, Pigmentation | | 2 1.0|
Pancreatic, Hemorrhage | | 1 2.0|
Pancreatic, Hyperplasia | | 5 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 1 2 2 1 2 | 21 1.8|
Pancreatic, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + | 66 |
Hemorrhage | | 5 1.4|
Hyperplasia | 2 | 2 2.0|
Infiltration Cellular, Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 69 |
Depletion Lymphoid | 2 | 2 2.5|
Hemorrhage | 2 | 4 1.8|
Infiltration Cellular, Histiocyte | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 | 67 1.2|
Pigmentation | 1 1 | 8 1.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Depletion Lymphoid | | 3 2.3|
Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + I + + + + + + + + + M M + + + M + | 61 |
Depletion Lymphoid | 2 | 1 2.0|
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M M + + + + + M + + + + | 54 |
Hyperplasia | 1 1 2 1 1 1 1 2 2 1 2 1 1 | 41 1.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst Epithelial Inclusion | | 2 2.5|
Foreign Body | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 2 | 6 1.2|
Foot, Acanthosis | | 1 2.0|
Foot, Hyperkeratosis | | 1 2.0|
Foot, Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2| | |
DAY ON TEST | 2| 2| 1| 0| 7| 3| 3| 0| 9| 7| 3| 3| 2| 4| 0| 2| 2| 6| 4| 8| | |
| 9| 9| 4| 9| 5| 0| 0| 8| 5| 9| 0| 0| 5| 9| 1| 9| 9| 0| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
71MLF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Infarct | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Fibrosis | | 2 1.0|
Hemorrhage | | 1 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 53 1.0|
Inflammation, Chronic Active | | 3 1.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Artery, Mineralization | 1 1 1 1 1 | 23 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Foreign Body | 1 2 | 4 1.8|
Inflammation, Chronic Active | 1 4 2 3 | 13 2.3|
Metaplasia, Squamous | 3 | 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 8 |
External Ear, Inflammation, Acute | | 2 3.0|
Internal Ear, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Eye | + + | 7 |
Phthisis Bulbi | | 1 4.0|
Lens, Cataract | 2 | 1 2.0|
Retina, Degeneration | 3 4 | 3 3.3|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Abscess | | 1 2.0|
Autolysis | | 3 2.7|
Cyst | | 2 1.5|
Fibrosis | 2 | 1 2.0|
Hydronephrosis | | 2 2.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 7 1.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 2| 7| 7| 7| 6| 6| 7| 7| 6| 6| 2| | |
DAY ON TEST | 2| 2| 1| 0| 7| 3| 3| 0| 9| 7| 3| 3| 2| 4| 0| 2| 2| 6| 4| 8| | |
| 9| 9| 4| 9| 5| 0| 0| 8| 5| 9| 0| 0| 5| 9| 1| 9| 9| 0| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
71MLF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 3 3 3 2 2 3 3 2 3 3 3 4 2 3 3 3 2 3 | 60 2.7|
Pigmentation | | 1 2.0|
Artery, Thrombosis | | 1 4.0|
Pelvis, Inflammation, Chronic Active | 3 | 4 2.5|
Pelvis, Metaplasia, Squamous | 3 | 3 3.0|
Renal Tubule, Hyperplasia | 3 3 2 3 4 3 4 3 | 23 2.7|
Renal Tubule, Hyperplasia, Oncocytic | | 1 4.0|
Renal Tubule, Inflammation, Acute | | 3 1.0|
Renal Tubule, Inflammation, Chronic | | |
Active | 1 | 2 1.0|
Renal Tubule, Pigmentation | 2 2 2 1 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 | 70 2.0|
Renal Tubule, Regeneration | 1 1 | 7 1.0|
Transitional Epithelium, Hyperplasia | 1 1 2 1 1 1 4 2 4 1 | 44 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | | 2 3.0|
Fibrosis | 1 | 1 1.0|
Hyperplasia, Lymphoid | 1 | 3 1.3|
Inflammation, Chronic Active | 1 | 3 1.0|
Fat, Proliferation | 2 3 | 4 2.3|
Transitional Epithelium, Hyperplasia | 3 2 4 1 2 2 2 2 3 3 1 2 | 41 2.0|
Transitional Epithelium, Metaplasia, | | |
Squamous | 2 | 4 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 2| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 7| 6| 6| 5| 4|
DAY ON TEST | 2| 2| 9| 6| 7| 2| 2| 0| 1| 6| 2| 8| 6| 6| 6| 2| 2| 7| 6| 1| 0| 3| 1| 8| 6|
| 9| 9| 5| 6| 9| 9| 9| 2| 6| 4| 0| 5| 2| 2| 2| 9| 2| 4| 9| 8| 2| 8| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 3 |
Parasite Metazoan | 1 1 1 |
Lymphoid Tissue, Hemorrhage | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +|
Autolysis | |
Diverticulum | |
Inflammation, Acute, Necrotizing | 2 |
Parasite Metazoan | 1 1 1 1 1 |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A |
Autolysis | 3 4 |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A |
Autolysis | 3 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + + + + + A |
Autolysis | 2 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Basophilic Focus | 1 3 1 2 2 1|
Clear Cell Focus | 2 1 3 1 1 |
Developmental Malformation | |
Eosinophilic Focus | 4 |
Fatty Change | 1 1 1 3 1 1|
Hematopoietic Cell Proliferation | 1 1 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic, Granulomatous | 1 1 2 |
Inflammation, Chronic Active | 1 1 |
Mixed Cell Focus | 1 1 |
Necrosis, Coagulative | 4 1 1 2 3 |
Pigmentation | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Thrombosis | |
Bile Duct, Hyperplasia | 2 1 1 1 2 1 1 1 1 2 1 1 2 1 1 1 2 3 2 1|
Periportal, Inflammation, Chronic | 1 1 1 2|
Periportal, Inflammation, Chronic | |
Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Mesentery | + + M |
Fibrosis | 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 2| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 7| 6| 6| 5| 4|
DAY ON TEST | 2| 2| 9| 6| 7| 2| 2| 0| 1| 6| 2| 8| 6| 6| 6| 2| 2| 7| 6| 1| 0| 3| 1| 8| 6|
| 9| 9| 5| 6| 9| 9| 9| 2| 6| 4| 0| 5| 2| 2| 2| 9| 2| 4| 9| 8| 2| 8| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Pigmentation | |
Polyarteritis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + |
Atrophy | 1 1 1 2 1 2 1 |
Autolysis | |
Cytoplasmic Alteration | 2 |
Infiltration Cellular, Mononuclear | |
Cell | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 |
Vacuolization Cytoplasmic | |
Acinus, Hyperplasia | 1 |
__________________________________________________________________________|
Pharynx | |
Hemorrhage | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Mononuclear | |
Cell | |
Parotid Gland, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + M + + + + + + + + +|
Cyst Epithelial Inclusion | 4 |
Erosion | 3 |
Hyperkeratosis | 1 3 3 2 2 2 1 1 2 2 2 2 2 |
Hyperplasia, Basal Cell | 2 2 2 2 1 1 1 1 2 2 3 |
Hyperplasia, Squamous | 3 4 4 4 2 3 3 2 4 3 4 2 4 3 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 2 2 4 |
Ulcer | 3 2 3 3 3 3 4 3 2 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 1 1 1 3 |
Necrosis, Coagulative | |
Ulcer | 4 |
__________________________________________________________________________|
Tongue | |
Foreign Body | |
Inflammation, Chronic | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 2| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 7| 6| 6| 5| 4|
DAY ON TEST | 2| 2| 9| 6| 7| 2| 2| 0| 1| 6| 2| 8| 6| 6| 6| 2| 2| 7| 6| 1| 0| 3| 1| 8| 6|
| 9| 9| 5| 6| 9| 9| 9| 2| 6| 4| 0| 5| 2| 2| 2| 9| 2| 4| 9| 8| 2| 8| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Angiectasis | 2 1 2 2 1 1 2 2 1 1 |
Autolysis | 2 3 |
Hyperplasia | 1 |
Vacuolization Cytoplasmic | 2 1 2 1 2 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 3 |
Hyperplasia | 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + M + M + + + M M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + M + + + + + + + + + + + |
Pars Distalis, Autolysis | |
Pars Distalis, Cyst | 2 2 2 1 2 1 |
Pars Distalis, Cyst, Multiple | 2 1 |
Pars Distalis, Hyperplasia | 1 2 1 1 1 |
Pars Distalis, Necrosis, Coagulative | |
Rathke's Cleft, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 3 3 |
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + + + + + + + |
Abscess | |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 2 1 3 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Ovary | + + + + + + + M + + + + + + + + + + + + + + +|
Congestion | |
Cyst | 4 4|
Periovarian Tissue, Cyst | 4 4|
__________________________________________________________________________|
Uterus | + + + + + + + M + + + + + + + + + + + + + + |
Autolysis | |
Cyst | 4 4 |
Fibrosis | |
Hydrometra | 2 1 4 3 |
Inflammation, Chronic Active | 4 |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + M + + + + |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 2| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 7| 6| 6| 5| 4|
DAY ON TEST | 2| 2| 9| 6| 7| 2| 2| 0| 1| 6| 2| 8| 6| 6| 6| 2| 2| 7| 6| 1| 0| 3| 1| 8| 6|
| 9| 9| 5| 6| 9| 9| 9| 2| 6| 4| 0| 5| 2| 2| 2| 9| 2| 4| 9| 8| 2| 8| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | |
Iliac, Infiltration Cellular, | |
Histiocyte | |
Lumbar, Hemorrhage | |
Lumbar, Infiltration Cellular, | |
Histiocyte | 2 |
Lumbar, Pigmentation | |
Mediastinal, Hemorrhage | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 |
Mediastinal, Pigmentation | |
Pancreatic, Hemorrhage | |
Pancreatic, Hyperplasia | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 3 2 2 |
Pancreatic, Pigmentation | 1 |
Renal, Hemorrhage | |
Renal, Infiltration Cellular, | |
Histiocyte | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + M M + + + + + + |
Autolysis | |
Depletion Lymphoid | 3 |
Hemorrhage | |
Hyperplasia | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 3 |
Depletion Lymphoid | 2 3 2 |
Hemorrhage | 2 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 |
Pigmentation | 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Autolysis | |
Congestion | |
Depletion Lymphoid | 1 2 2 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + + M + + M + M + + + + + + + + M + + + + + + + +|
Cyst | 2|
Depletion Lymphoid | 2 1 2|
Hemorrhage | |
Pigmentation | 2|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 2| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 7| 6| 6| 5| 4|
DAY ON TEST | 2| 2| 9| 6| 7| 2| 2| 0| 1| 6| 2| 8| 6| 6| 6| 2| 2| 7| 6| 1| 0| 3| 1| 8| 6|
| 9| 9| 5| 6| 9| 9| 9| 2| 6| 4| 0| 5| 2| 2| 2| 9| 2| 4| 9| 8| 2| 8| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + + + M + + + + + + + + + + + + + + |
Hyperplasia | 2 1 1 1 1 1 1 2 1 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Abscess | |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
Cranium, Osteopetrosis | 2 |
Femur, Osteopetrosis | 4 |
Sternum, Osteopetrosis | 4 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Acute | |
Inflammation, Chronic Active | |
Polyarteritis | |
Alveolar Epithelium, Hyperplasia | |
Artery, Mineralization | 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
Autolysis | |
Inflammation, Chronic Active | 2 1 1 3 |
Metaplasia, Squamous | |
Arteriole, Thrombosis | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
Synechia | 4 |
Cornea, Inflammation, Acute | 1 |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 3 |
Infiltration Cellular, Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 2| 7| 7| 7| 6| 4| 7| 6| 6| 4| 4| 7| 7| 6| 5| 4| 7| 6| 6| 5| 4|
DAY ON TEST | 2| 2| 9| 6| 7| 2| 2| 0| 1| 6| 2| 8| 6| 6| 6| 2| 2| 7| 6| 1| 0| 3| 1| 8| 6|
| 9| 9| 5| 6| 9| 9| 9| 2| 6| 4| 0| 5| 2| 2| 2| 9| 2| 4| 9| 8| 2| 8| 0| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cell | |
Nephropathy | 3 4 2 2 2 2 3 3 2 3 4 3 3 2 2 3 2 3 2 2 3 3 2 4|
Papilla, Necrosis, Coagulative | |
Pelvis, Inflammation, Chronic Active | 3 3 |
Pelvis, Metaplasia, Squamous | 4 |
Renal Tubule, Hyperplasia | 3 4 2 3 3 1 2 4 3 4 3 3 |
Renal Tubule, Inflammation, Chronic | |
Active | 1 1 1 1 |
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2|
Renal Tubule, Regeneration | |
Transitional Epithelium, Hyperplasia | 4 2 1 1 1 1 1 1 1 1 4|
Transitional Epithelium, | |
Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | |
Hemorrhage | 1 |
Infiltration Cellular, Mononuclear | |
Cell | |
Inflammation, Chronic | 2|
Inflammation, Chronic Active | |
Necrosis | |
Fat, Proliferation | |
Transitional Epithelium, Hyperplasia | 1 2 3 3 1 2 3 2 1 2 2 3 2 3 1 3 3 3 4|
Transitional Epithelium, | |
Infiltration Cellular, | |
Mononuclear Cell | |
Transitional Epithelium, Metaplasia, | |
Squamous | 4 1 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 2| 7| 7| 6| 6| 2| 7| 7| 5| 4| 0| 6| 4| 4| 2| 2| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 2| 4| 8| 2| 2| 3| 1| 8| 2| 1| 9| 6| 4| 5| 6| 6| 7| 7| 2| 1| 0| 0| 5|
| 6| 6| 5| 3| 1| 9| 9| 5| 4| 1| 9| 4| 8| 4| 2| 8| 2| 2| 9| 9| 9| 5| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + M + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | 1 |
Lymphoid Tissue, Hemorrhage | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + +|
Autolysis | |
Diverticulum | |
Inflammation, Acute, Necrotizing | 1 |
Parasite Metazoan | 1 |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + M + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + M + + + M + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + M + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M M + + + + + + + + + + + +|
Autolysis | 2 |
__________________________________________________________________________|
Liver | + + + + + + + M + + + + + + + + + + + + + + + +|
Abscess | 2 |
Basophilic Focus | 1 2 1 2 1 1 1 1 1 1 2 1|
Clear Cell Focus | 2 1 1 2 1 2 1 2 2 1|
Developmental Malformation | |
Eosinophilic Focus | |
Fatty Change | 2 1 1 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic, Granulomatous | 1 1 |
Inflammation, Chronic Active | 1 |
Mixed Cell Focus | 2 3|
Necrosis, Coagulative | 1 1 2 1 1 1 |
Pigmentation | 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 2 1 1|
Thrombosis | 2 |
Bile Duct, Hyperplasia | 1 1 2 2 2 2 2 1 1 1 1 1 1 1 2 2 2 1|
Periportal, Inflammation, Chronic | 1 1 1 |
Periportal, Inflammation, Chronic | |
Active | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1|
__________________________________________________________________________|
Mesentery | M M + M M + |
Fibrosis | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 2| 7| 7| 6| 6| 2| 7| 7| 5| 4| 0| 6| 4| 4| 2| 2| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 2| 4| 8| 2| 2| 3| 1| 8| 2| 1| 9| 6| 4| 5| 6| 6| 7| 7| 2| 1| 0| 0| 5|
| 6| 6| 5| 3| 1| 9| 9| 5| 4| 1| 9| 4| 8| 4| 2| 8| 2| 2| 9| 9| 9| 5| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Pigmentation | |
Polyarteritis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + M + + + + + + + + + + M + +|
Atrophy | 1 3 1 2|
Autolysis | |
Cytoplasmic Alteration | |
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1|
Vacuolization Cytoplasmic | 1 1 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Pharynx | |
Hemorrhage | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | |
Parotid Gland, Inflammation, Chronic | |
Active | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Erosion | 3 |
Hyperkeratosis | 2 2 1 2 3 1 2 1 2 2 2|
Hyperplasia, Basal Cell | 1 2 2 1 4 2 4 2 2 2 2 2|
Hyperplasia, Squamous | 3 3 3 3 3 2 3 1 2 3 3 3 2|
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 2 3 3 |
Ulcer | 3 2 4 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + M + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 3 |
Necrosis, Coagulative | |
Ulcer | |
__________________________________________________________________________|
Tongue | +|
Foreign Body | 1|
Inflammation, Chronic | 2|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 1 2 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + M + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 2| 7| 7| 6| 6| 2| 7| 7| 5| 4| 0| 6| 4| 4| 2| 2| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 2| 4| 8| 2| 2| 3| 1| 8| 2| 1| 9| 6| 4| 5| 6| 6| 7| 7| 2| 1| 0| 0| 5|
| 6| 6| 5| 3| 1| 9| 9| 5| 4| 1| 9| 4| 8| 4| 2| 8| 2| 2| 9| 9| 9| 5| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Angiectasis | 2 1 2 1 1 1 1 1 2 2 1|
Autolysis | |
Hyperplasia | |
Vacuolization Cytoplasmic | 1 1 1 1 2 2 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + M + + + + + + + + M + + + +|
Autolysis | |
Hyperplasia | 2 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + M + + + + + + + M + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + M + + + + + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Autolysis | 3 |
Pars Distalis, Cyst | 1 1 2 2 2 |
Pars Distalis, Cyst, Multiple | 2 |
Pars Distalis, Hyperplasia | 1 |
Pars Distalis, Necrosis, Coagulative | 1 |
Rathke's Cleft, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Ovary | + + + + + + + M + + + + + + + + + + + + + +|
Congestion | |
Cyst | 4 1 |
Periovarian Tissue, Cyst | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + M + + + + + + + + + + + + +|
Autolysis | |
Cyst | |
Fibrosis | 3 |
Hydrometra | 2 1 1 1 |
Inflammation, Chronic Active | |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + M + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 2| 7| 7| 6| 6| 2| 7| 7| 5| 4| 0| 6| 4| 4| 2| 2| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 2| 4| 8| 2| 2| 3| 1| 8| 2| 1| 9| 6| 4| 5| 6| 6| 7| 7| 2| 1| 0| 0| 5|
| 6| 6| 5| 3| 1| 9| 9| 5| 4| 1| 9| 4| 8| 4| 2| 8| 2| 2| 9| 9| 9| 5| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pigmentation | 1 |
Iliac, Infiltration Cellular, | |
Histiocyte | 1 |
Lumbar, Hemorrhage | |
Lumbar, Infiltration Cellular, | |
Histiocyte | |
Lumbar, Pigmentation | |
Mediastinal, Hemorrhage | 1 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Pigmentation | |
Pancreatic, Hemorrhage | 2 |
Pancreatic, Hyperplasia | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 2 2 4 3 |
Pancreatic, Pigmentation | 2 2 1 |
Renal, Hemorrhage | 1 |
Renal, Infiltration Cellular, | |
Histiocyte | 3 |
Renal, Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + M + + + + + + M + + + + + +|
Autolysis | |
Depletion Lymphoid | |
Hemorrhage | 1 1 |
Hyperplasia | |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + +|
Autolysis | |
Depletion Lymphoid | 2 3 |
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 1 1 1 1 3 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 2|
Pigmentation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + M + + + + + + + + + + + + +|
Autolysis | |
Congestion | |
Depletion Lymphoid | 2 1 1 |
Fibrosis | |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + M + + + + + + + + + + M M|
Cyst | |
Depletion Lymphoid | 3 |
Hemorrhage | |
Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 2| 7| 7| 6| 6| 2| 7| 7| 5| 4| 0| 6| 4| 4| 2| 2| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 2| 4| 8| 2| 2| 3| 1| 8| 2| 1| 9| 6| 4| 5| 6| 6| 7| 7| 2| 1| 0| 0| 5|
| 6| 6| 5| 3| 1| 9| 9| 5| 4| 1| 9| 4| 8| 4| 2| 8| 2| 2| 9| 9| 9| 5| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + M + + M + + M + + + M M + + M + +|
Hyperplasia | 1 1 2 1 2 2 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | |
Femur, Osteopetrosis | |
Sternum, Osteopetrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Acute | |
Inflammation, Chronic Active | 2|
Polyarteritis | 4 |
Alveolar Epithelium, Hyperplasia | |
Artery, Mineralization | 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 2 1 4 |
Metaplasia, Squamous | |
Arteriole, Thrombosis | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
Synechia | |
Cornea, Inflammation, Acute | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + M + + + + + + + + + + + + + + + +|
Autolysis | |
Infiltration Cellular, Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 6| 6| 6| 5| 2| 7| 7| 6| 6| 2| 7| 7| 5| 4| 0| 6| 4| 4| 2| 2| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 2| 4| 8| 2| 2| 3| 1| 8| 2| 1| 9| 6| 4| 5| 6| 6| 7| 7| 2| 1| 0| 0| 5|
| 6| 6| 5| 3| 1| 9| 9| 5| 4| 1| 9| 4| 8| 4| 2| 8| 2| 2| 9| 9| 9| 5| 5| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cell | 2 |
Nephropathy | 2 3 3 3 3 3 3 3 3 2 2 3 2 2 3 3 3 2 2|
Papilla, Necrosis, Coagulative | |
Pelvis, Inflammation, Chronic Active | 3 |
Pelvis, Metaplasia, Squamous | 3 |
Renal Tubule, Hyperplasia | 2 2 1 4 3 4 2 2 1 3 3 3 1 |
Renal Tubule, Inflammation, Chronic | |
Active | 1 1 |
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Renal Tubule, Regeneration | 1 |
Transitional Epithelium, Hyperplasia | 1 1 1 3 1 1 1 |
Transitional Epithelium, | |
Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | 2 |
Hemorrhage | 2 |
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 |
Necrosis | 2 |
Fat, Proliferation | 2 |
Transitional Epithelium, Hyperplasia | 3 2 2 2 2 2 3 2 2 4 3 3 2 3 3 1 1 4 2|
Transitional Epithelium, | |
Infiltration Cellular, | |
Mononuclear Cell | 1 |
Transitional Epithelium, Metaplasia, | |
Squamous | 4 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 2| 2| 7| 7| 6| 5| 5| 7| 6| 6| 4| 2| 4| 4| 3| 2| 2| | |
DAY ON TEST | 1| 3| 6| 7| 7| 2| 2| 7| 7| 1| 2| 6| 6| 6| 7| 6| 6| 6| 8| 7| | |
| 9| 7| 0| 9| 9| 9| 9| 3| 6| 2| 9| 4| 2| 2| 9| 4| 4| 7| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | M + + + + + + + + + + + + + + + + | 57 |
Autolysis | 4 | 3 3.0|
Parasite Metazoan | 1 1 1 | 7 1.0|
Lymphoid Tissue, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 67 |
Autolysis | 3 | 1 3.0|
Diverticulum | 1 | 1 1.0|
Inflammation, Acute, Necrotizing | 2 | 3 1.7|
Parasite Metazoan | 1 1 1 | 9 1.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + | 57 |
Autolysis | 3 4 | 4 3.5|
Parasite Metazoan | 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + | 56 |
Autolysis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + | 56 |
Autolysis | 4 | 3 3.7|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + | 54 |
Autolysis | 4 | 4 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 68 |
Abscess | | 1 2.0|
Basophilic Focus | 1 2 1 2 1 3 1 1 | 26 1.4|
Clear Cell Focus | 2 1 3 1 2 2 2 1 | 23 1.6|
Developmental Malformation | X | 1 |
Eosinophilic Focus | | 1 4.0|
Fatty Change | 2 2 1 1 | 14 1.4|
Hematopoietic Cell Proliferation | | 2 1.0|
Hemorrhage | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Chronic, Granulomatous | 1 | 6 1.2|
Inflammation, Chronic Active | 1 1 1 2 | 7 1.1|
Mixed Cell Focus | | 4 1.8|
Necrosis, Coagulative | 1 1 1 1 1 1 | 17 1.4|
Pigmentation | 1 1 1 1 1 1 1 1 2 2 1 1 2 1 1 1 1 | 61 1.1|
Thrombosis | | 1 2.0|
Bile Duct, Hyperplasia | 1 1 1 1 2 2 1 2 2 1 1 2 1 1 2 1 1 | 55 1.4|
Periportal, Inflammation, Chronic | 1 1 1 | 10 1.1|
Periportal, Inflammation, Chronic | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 2| 2| 7| 7| 6| 5| 5| 7| 6| 6| 4| 2| 4| 4| 3| 2| 2| | |
DAY ON TEST | 1| 3| 6| 7| 7| 2| 2| 7| 7| 1| 2| 6| 6| 6| 7| 6| 6| 6| 8| 7| | |
| 9| 7| 0| 9| 9| 9| 9| 3| 6| 2| 9| 4| 2| 2| 9| 4| 4| 7| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Active | 1 1 1 1 1 2 1 1 2 1 1 1 1 2 | 47 1.1|
__________________________________________________________________________|____________|
Mesentery | M M M + M M | 5 |
Fibrosis | | 1 2.0|
Inflammation, Chronic | 4 | 1 4.0|
Inflammation, Chronic Active | | 1 1.0|
Pigmentation | 3 | 1 3.0|
Polyarteritis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + | 58 |
Atrophy | 1 1 3 1 | 15 1.5|
Autolysis | 3 | 1 3.0|
Cytoplasmic Alteration | | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell | | 1 1.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 1 1 1 1 2 | 22 1.1|
Vacuolization Cytoplasmic | 1 | 3 1.0|
Acinus, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + M + + + + + + + | 58 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 | 2 1.0|
Parotid Gland, Inflammation, Chronic | | |
Active | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 67 |
Cyst Epithelial Inclusion | | 1 4.0|
Erosion | 2 | 3 2.7|
Hyperkeratosis | 2 2 1 2 | 28 1.9|
Hyperplasia, Basal Cell | 2 2 2 2 1 2 | 29 1.9|
Hyperplasia, Squamous | 3 4 3 3 4 3 | 33 3.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 2 2 | 10 2.2|
Ulcer | 4 3 | 17 2.9|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 68 |
Autolysis | 2 | 1 2.0|
Inflammation, Chronic Active | 1 | 6 1.7|
Necrosis, Coagulative | 2 | 1 2.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 2| 2| 7| 7| 6| 5| 5| 7| 6| 6| 4| 2| 4| 4| 3| 2| 2| | |
DAY ON TEST | 1| 3| 6| 7| 7| 2| 2| 7| 7| 1| 2| 6| 6| 6| 7| 6| 6| 6| 8| 7| | |
| 9| 7| 0| 9| 9| 9| 9| 3| 6| 2| 9| 4| 2| 2| 9| 4| 4| 7| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Foreign Body | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 59 |
Cardiomyopathy | 1 1 1 1 2 1 1 1 1 1 1 | 43 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + | 58 |
Angiectasis | 1 1 1 1 1 | 26 1.3|
Autolysis | 2 | 3 2.3|
Hyperplasia | | 1 1.0|
Vacuolization Cytoplasmic | 1 1 1 2 1 | 20 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + | 58 |
Autolysis | | 1 3.0|
Hyperplasia | 1 | 14 1.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + M + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 57 |
Pars Distalis, Autolysis | | 1 3.0|
Pars Distalis, Cyst | 1 1 1 2 1 2 1 | 18 1.5|
Pars Distalis, Cyst, Multiple | | 3 1.7|
Pars Distalis, Hyperplasia | 2 2 | 8 1.4|
Pars Distalis, Necrosis, Coagulative | | 1 1.0|
Rathke's Cleft, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + | 59 |
Autolysis | 3 | 4 3.0|
C-Cell, Hyperplasia | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M M + + + + + + + + + + + + + + | 58 |
Abscess | 2 | 1 2.0|
Inflammation, Chronic | | 3 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 | 31 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 2| 2| 7| 7| 6| 5| 5| 7| 6| 6| 4| 2| 4| 4| 3| 2| 2| | |
DAY ON TEST | 1| 3| 6| 7| 7| 2| 2| 7| 7| 1| 2| 6| 6| 6| 7| 6| 6| 6| 8| 7| | |
| 9| 7| 0| 9| 9| 9| 9| 3| 6| 2| 9| 4| 2| 2| 9| 4| 4| 7| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + | 61 |
Congestion | 1 | 1 1.0|
Cyst | 2 1 | 6 2.7|
Periovarian Tissue, Cyst | 2 | 4 3.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + | 60 |
Autolysis | 3 | 1 3.0|
Cyst | 2 | 3 3.3|
Fibrosis | | 1 3.0|
Hydrometra | 1 4 2 1 | 12 1.9|
Inflammation, Chronic Active | | 1 4.0|
Endometrium, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + M + + | 24 |
Pigmentation | | 1 1.0|
Iliac, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Lumbar, Hemorrhage | 2 | 1 2.0|
Lumbar, Infiltration Cellular, | | |
Histiocyte | 2 | 2 2.0|
Lumbar, Pigmentation | 1 | 1 1.0|
Mediastinal, Hemorrhage | 2 1 | 3 1.3|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 1 1 | 3 1.3|
Mediastinal, Pigmentation | 1 1 | 2 1.0|
Pancreatic, Hemorrhage | 1 1 | 3 1.3|
Pancreatic, Hyperplasia | 2 | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 2 1 2 | 11 2.3|
Pancreatic, Pigmentation | | 4 1.5|
Renal, Hemorrhage | | 1 1.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Renal, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + | 53 |
Autolysis | 2 | 1 2.0|
Depletion Lymphoid | | 1 3.0|
Hemorrhage | 1 2 | 4 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 2| 2| 7| 7| 6| 5| 5| 7| 6| 6| 4| 2| 4| 4| 3| 2| 2| | |
DAY ON TEST | 1| 3| 6| 7| 7| 2| 2| 7| 7| 1| 2| 6| 6| 6| 7| 6| 6| 6| 8| 7| | |
| 9| 7| 0| 9| 9| 9| 9| 3| 6| 2| 9| 4| 2| 2| 9| 4| 4| 7| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 | 9 1.0|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + | 60 |
Autolysis | 4 | 2 3.5|
Depletion Lymphoid | 3 3 2 | 8 2.5|
Hemorrhage | | 3 2.3|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 | 59 1.2|
Pigmentation | 2 | 4 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 58 |
Autolysis | 2 | 1 2.0|
Congestion | 2 | 1 2.0|
Depletion Lymphoid | 1 | 7 1.4|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + M M + + + + M M + + + + M + + + + | 55 |
Cyst | | 1 2.0|
Depletion Lymphoid | | 4 2.0|
Hemorrhage | 2 | 1 2.0|
Pigmentation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + + + M + + + + + + | 47 |
Hyperplasia | 1 1 3 2 2 2 2 | 26 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + | 60 |
Abscess | | 1 3.0|
Inflammation, Chronic Active | | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + | 59 |
Cranium, Osteopetrosis | | 1 2.0|
Femur, Osteopetrosis | | 1 4.0|
Sternum, Osteopetrosis | | 3 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 2| 2| 7| 7| 6| 5| 5| 7| 6| 6| 4| 2| 4| 4| 3| 2| 2| | |
DAY ON TEST | 1| 3| 6| 7| 7| 2| 2| 7| 7| 1| 2| 6| 6| 6| 7| 6| 6| 6| 8| 7| | |
| 9| 7| 0| 9| 9| 9| 9| 3| 6| 2| 9| 4| 2| 2| 9| 4| 4| 7| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + | 64 |
Infiltration Cellular, Histiocyte | 1 1 2 1 1 1 1 1 1 1 1 | 43 1.0|
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic Active | 2 | 2 2.0|
Polyarteritis | | 1 4.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Artery, Mineralization | 1 1 1 1 1 2 1 | 18 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + | 59 |
Autolysis | 2 | 1 2.0|
Inflammation, Chronic Active | 1 2 2 4 3 | 12 2.2|
Metaplasia, Squamous | 2 2 | 2 2.0|
Arteriole, Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 3 |
__________________________________________________________________________|____________|
Eye | + | 7 |
Synechia | | 1 4.0|
Cornea, Inflammation, Acute | | 1 1.0|
Retina, Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 68 |
Autolysis | 2 | 3 2.7|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 | 3 1.3|
Nephropathy | 3 2 3 3 3 2 3 2 2 2 3 3 2 | 56 2.6|
Papilla, Necrosis, Coagulative | 4 3 | 2 3.5|
Pelvis, Inflammation, Chronic Active | 2 2 2 | 6 2.5|
Pelvis, Metaplasia, Squamous | | 2 3.5|
Renal Tubule, Hyperplasia | 2 1 3 4 1 | 30 2.6|
Renal Tubule, Inflammation, Chronic | | |
Active | 1 | 7 1.0|
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 | 68 2.0|
Renal Tubule, Regeneration | 1 1 1 | 4 1.0|
Transitional Epithelium, Hyperplasia | 1 4 1 3 2 1 2 | 25 1.6|
Transitional Epithelium, | | |
Mineralization | | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + | 66 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 2| 2| 7| 7| 6| 5| 5| 7| 6| 6| 4| 2| 4| 4| 3| 2| 2| | |
DAY ON TEST | 1| 3| 6| 7| 7| 2| 2| 7| 7| 1| 2| 6| 6| 6| 7| 6| 6| 6| 8| 7| | |
| 9| 7| 0| 9| 9| 9| 9| 3| 6| 2| 9| 4| 2| 2| 9| 4| 4| 7| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
71MHF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 1 2.0|
Hemorrhage | | 2 1.5|
Infiltration Cellular, Mononuclear | | |
Cell | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Necrosis | | 1 2.0|
Fat, Proliferation | 3 | 2 2.5|
Transitional Epithelium, Hyperplasia | 2 2 1 1 1 3 3 2 4 2 3 2 2 2 | 52 2.3|
Transitional Epithelium, | | |
Infiltration Cellular, | | |
Mononuclear Cell | | 1 1.0|
Transitional Epithelium, Metaplasia, | | |
Squamous | 3 4 | 8 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 2| 2| 4| 4| 0| 4| 3| 4| 4| 2| 2| 2| 4| 3| 2| 2| 2| 4| 4| 4| 4| 2|
DAY ON TEST | 6| 6| 2| 8| 7| 6| 6| 6| 6| 0| 6| 6| 9| 9| 7| 4| 1| 7| 7| 7| 6| 6| 6| 2| 7|
| 4| 2| 6| 1| 9| 4| 2| 5| 2| 6| 4| 4| 9| 4| 9| 1| 3| 9| 9| 9| 4| 4| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Basophilic Focus | 1 1 1 1 2 1 1 2 2 1 2 2 2 |
Clear Cell Focus | 2 1 1 2 1 1 1 1 1 1 1 1 |
Cytomegaly | 1 1 |
Eosinophilic Focus | 2 1 |
Fatty Change | 1 1 1 2 1 2 1 1 1 1 1 1|
Hematopoietic Cell Proliferation | 1 |
Inflammation, Chronic, Granulomatous | 2 |
Inflammation, Chronic Active | 1 |
Mixed Cell Focus | 1 2 2 |
Necrosis, Coagulative | 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 2 2 1 1 1 1 1 2 1 1 1 1 2 1 2 1 1|
Bile Duct, Hyperplasia | 2 2 1 1 1 2 2 2 1 2 2 1 1 1 2 1 1 1 2 1 1 1 1|
Periportal, Inflammation, Chronic | 2 2 2 3 2 2 2 2 2 2 |
Periportal, Inflammation, Chronic | |
Active | 1 1 2 1 1 1 1 1 2 1 2 1 2|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic, Granulomatous | 4 |
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 2 |
Ectopic Tissue | 1 |
Infiltration Cellular, Mononuclear | |
Cell | 1 2|
Inflammation, Chronic | 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Submandibular Gland, Dilatation| 3 |
Parotid Gland, Atrophy | 2 |
Parotid Gland, Inflammation, Chronic | 1 1 |
Parotid Gland, Inflammation, Chronic | |
Active | 1 1 |
Submandibular Gland, Atrophy | 2 |
Submandibular Gland, Inflammation, | |
Chronic | 1 |
Submandibular Gland, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 2| 2| 4| 4| 0| 4| 3| 4| 4| 2| 2| 2| 4| 3| 2| 2| 2| 4| 4| 4| 4| 2|
DAY ON TEST | 6| 6| 2| 8| 7| 6| 6| 6| 6| 0| 6| 6| 9| 9| 7| 4| 1| 7| 7| 7| 6| 6| 6| 2| 7|
| 4| 2| 6| 1| 9| 4| 2| 5| 2| 6| 4| 4| 9| 4| 9| 1| 3| 9| 9| 9| 4| 4| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Chronic Active | 2 2 2 3 2 |
Submandibular Gland, Metaplasia, | |
Squamous | 2 1 |
Submandibular Gland, Pigmentation | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Erosion | 2 |
Hyperkeratosis | 1 |
Hyperplasia, Basal Cell | 1 1 1 1 1 |
Hyperplasia, Squamous | 2 2 |
Ulcer | 3 |
Muscularis, Mineralization | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Artery, Mineralization | 1 |
Muscularis, Mineralization | 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 1 1 2 2 1 1 2 3 1 1|
Pars Distalis, Hyperplasia | 2 |
Pars Intermedia, Cyst | 2 1 1 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 2| 2| 4| 4| 0| 4| 3| 4| 4| 2| 2| 2| 4| 3| 2| 2| 2| 4| 4| 4| 4| 2|
DAY ON TEST | 6| 6| 2| 8| 7| 6| 6| 6| 6| 0| 6| 6| 9| 9| 7| 4| 1| 7| 7| 7| 6| 6| 6| 2| 7|
| 4| 2| 6| 1| 9| 4| 2| 5| 2| 6| 4| 4| 9| 4| 9| 1| 3| 9| 9| 9| 4| 4| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Periovarian Tissue, Cyst | 3 2 3 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 1 2 1 1 |
Inflammation, Chronic Active | 2 |
Endometrium, Hyperplasia | 2 |
Submucosa, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + M M + + + + M M +|
Mediastinal, Pigmentation | 2 1 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 3 3 2 3 3 3|
Pancreatic, Pigmentation | 2 2 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1|
Hyperplasia | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Hemorrhage | 1 3 1|
Infiltration Cellular, Histiocyte | 2 1 1 3 2 2 1 2 1 2 2 1 2 1 2 1 1 1 2 2 2 1 1|
Pigmentation | 2 1 2 1 1 1 2 2 2 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2|
Fibrosis | 1 |
__________________________________________________________________________|
Thymus | + + + + M + M + + + + + + + M + + + + + I M +|
Depletion Lymphoid | 2 3 1 1 2 |
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M M + + M + M + + + + + + M + + + M + +|
Hyperplasia | 1 2 1 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 2| 2| 4| 4| 0| 4| 3| 4| 4| 2| 2| 2| 4| 3| 2| 2| 2| 4| 4| 4| 4| 2|
DAY ON TEST | 6| 6| 2| 8| 7| 6| 6| 6| 6| 0| 6| 6| 9| 9| 7| 4| 1| 7| 7| 7| 6| 6| 6| 2| 7|
| 4| 2| 6| 1| 9| 4| 2| 5| 2| 6| 4| 4| 9| 4| 9| 1| 3| 9| 9| 9| 4| 4| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2.0% | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 3 |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | M M + M M M M +|
Anterior Chamber, Inflammation, Acute| 2|
Posterior Chamber, Inflammation, | |
Acute | 2|
Retina, Degeneration | 4|
__________________________________________________________________________|
Harderian Gland | M M M M M M +|
Hyperplasia | 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Fibrosis | 3 |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1|
Inflammation, Chronic Active | 3 |
Mineralization, Focal | |
Mineralization | 1 |
Nephropathy | 3 3 2 2 2 2 1 2 2 1 1 2 2 2 2 2 |
Papilla, Necrosis, Coagulative | 3 4 |
Pelvis, Inflammation, Chronic Active | 2 |
Renal Tubule, Hyperplasia | 2 1 |
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Renal Tubule, Regeneration | 1 1 1 1 1|
Transitional Epithelium, Hyperplasia | 1 3 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 4 4 2 |
Necrosis | 2 |
Fat, Proliferation | 3 3 |
Transitional Epithelium, Hyperplasia | 2 2 3 3 4 3 4 1 3 4 2 2 2 2 3 3 1|
Transitional Epithelium, Metaplasia, | |
Squamous | 2 4 2 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 2| 2| | |
DAY ON TEST | 6| 6| 8| 7| 7| | |
| 2| 1| 1| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| | A |
2.0% | 4| 4| 4| 4| 4| | L |
71HF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 28 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 28 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 27 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 28 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 28 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 27 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 28 |
__________________________________________________________________________|____________|
Liver | + + + + + | 28 |
Angiectasis | | 2 1.5|
Basophilic Focus | 1 2 2 | 16 1.5|
Clear Cell Focus | 1 1 | 14 1.1|
Cytomegaly | | 2 1.0|
Eosinophilic Focus | 2 | 3 1.7|
Fatty Change | 1 2 1 1 1 | 17 1.2|
Hematopoietic Cell Proliferation | | 1 1.0|
Inflammation, Chronic, Granulomatous | | 1 2.0|
Inflammation, Chronic Active | | 1 1.0|
Mixed Cell Focus | | 3 1.7|
Necrosis, Coagulative | 1 1 1 | 12 1.0|
Pigmentation | 1 1 2 1 | 27 1.2|
Bile Duct, Hyperplasia | 2 1 1 2 | 27 1.4|
Periportal, Inflammation, Chronic | 2 | 11 2.1|
Periportal, Inflammation, Chronic | | |
Active | 2 2 2 2 | 17 1.5|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Inflammation, Chronic, Granulomatous | | 1 4.0|
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 28 |
Atrophy | 1 | 5 1.2|
Ectopic Tissue | | 1 1.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 | 4 1.3|
Inflammation, Chronic | | 6 1.0|
Inflammation, Chronic Active | | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 28 |
Duct, Submandibular Gland, Dilatation| | 1 3.0|
Parotid Gland, Atrophy | | 1 2.0|
Parotid Gland, Inflammation, Chronic | | 2 1.0|
Parotid Gland, Inflammation, Chronic | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 2| 2| | |
DAY ON TEST | 6| 6| 8| 7| 7| | |
| 2| 1| 1| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| | A |
2.0% | 4| 4| 4| 4| 4| | L |
71HF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Active | | 2 1.0|
Submandibular Gland, Atrophy | | 1 2.0|
Submandibular Gland, Inflammation, | | |
Chronic | | 1 1.0|
Submandibular Gland, Inflammation, | | |
Chronic Active | | 5 2.2|
Submandibular Gland, Metaplasia, | | |
Squamous | | 2 1.5|
Submandibular Gland, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 28 |
Acanthosis | | 1 1.0|
Erosion | | 1 2.0|
Hyperkeratosis | | 1 1.0|
Hyperplasia, Basal Cell | 1 | 6 1.0|
Hyperplasia, Squamous | | 2 2.0|
Ulcer | | 1 3.0|
Muscularis, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 28 |
Inflammation, Chronic | | 1 1.0|
Artery, Mineralization | | 1 1.0|
Muscularis, Mineralization | | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 28 |
Cardiomyopathy | 1 1 | 18 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + M + + + | 27 |
Angiectasis | | 3 1.0|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + M + + + | 27 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 7 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + | 25 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 28 |
Pars Distalis, Angiectasis | 1 | 1 1.0|
Pars Distalis, Cyst | 2 | 11 1.5|
Pars Distalis, Hyperplasia | 1 | 2 1.5|
Pars Intermedia, Cyst | | 4 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 2| 2| | |
DAY ON TEST | 6| 6| 8| 7| 7| | |
| 2| 1| 1| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| | A |
2.0% | 4| 4| 4| 4| 4| | L |
71HF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 28 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 27 |
Cyst | | 1 4.0|
Inflammation, Chronic | 1 | 4 1.0|
Inflammation, Chronic Active | 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + | 28 |
Periovarian Tissue, Cyst | | 4 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + | 28 |
Hydrometra | | 6 1.5|
Inflammation, Chronic Active | | 1 2.0|
Endometrium, Hyperplasia | | 1 2.0|
Submucosa, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 28 |
__________________________________________________________________________|____________|
Lymph Node | + M + + | 9 |
Mediastinal, Pigmentation | 2 | 3 1.7|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 3 3 | 8 2.9|
Pancreatic, Pigmentation | 1 2 2 | 7 1.9|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 27 |
Hemorrhage | | 3 1.0|
Hyperplasia | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 1 | 7 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 28 |
Depletion Lymphoid | | 1 3.0|
Hemorrhage | 2 2 | 5 1.8|
Infiltration Cellular, Histiocyte | 2 1 1 1 1 | 28 1.5|
Pigmentation | 2 | 12 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + | 28 |
Congestion | | 1 2.0|
Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + M + + + | 22 |
Depletion Lymphoid | 2 | 6 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 2| 2| | |
DAY ON TEST | 6| 6| 8| 7| 7| | |
| 2| 1| 1| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| | A |
2.0% | 4| 4| 4| 4| 4| | L |
71HF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M M | 19 |
Hyperplasia | | 5 1.6|
__________________________________________________________________________|____________|
Skin | + + + + + | 28 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 28 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 28 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 28 |
Infiltration Cellular, Histiocyte | 1 1 | 17 1.0|
Inflammation, Chronic Active | | 1 3.0|
Artery, Mineralization | 1 1 1 | 12 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 28 |
Inflammation, Chronic Active | 1 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 28 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | M M M | 2 |
Anterior Chamber, Inflammation, Acute| | 1 2.0|
Posterior Chamber, Inflammation, | | |
Acute | | 1 2.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | M M M | 1 |
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 28 |
Fibrosis, Focal | 2 | 1 2.0|
Fibrosis | | 1 3.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 | 7 1.0|
Inflammation, Chronic Active | | 1 3.0|
Mineralization, Focal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 4| 2| 2| 2| | |
DAY ON TEST | 6| 6| 8| 7| 7| | |
| 2| 1| 1| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| | A |
2.0% | 4| 4| 4| 4| 4| | L |
71HF | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Mineralization | | 1 1.0|
Nephropathy | 4 2 | 18 2.1|
Papilla, Necrosis, Coagulative | | 2 3.5|
Pelvis, Inflammation, Chronic Active | | 1 2.0|
Renal Tubule, Hyperplasia | | 2 1.5|
Renal Tubule, Pigmentation | 2 2 2 2 2 | 28 2.0|
Renal Tubule, Regeneration | 1 1 | 7 1.0|
Transitional Epithelium, Hyperplasia | | 5 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 28 |
Hemorrhage | | 4 2.8|
Necrosis | | 1 2.0|
Fat, Proliferation | | 2 3.0|
Transitional Epithelium, Hyperplasia | 2 2 1 2 | 21 2.4|
Transitional Epithelium, Metaplasia, | | |
Squamous | | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| | |
| 4| 4| 4| 4| 2| 4| 4| 2| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.0% | 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
Parasite Metazoan | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
Parasite Metazoan | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
Parasite Metazoan | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus | 1 2 1 1 1 1 | 6 1.2|
Clear Cell Focus | 1 1 1 1 1 | 5 1.0|
Cyst | 3 | 1 3.0|
Cytomegaly | 1 | 1 1.0|
Cytoplasmic Alteration | 1 | 1 1.0|
Eosinophilic Focus | 1 1 | 2 1.0|
Inflammation, Chronic, Granulomatous | 1 1 | 2 1.0|
Mixed Cell Focus | 1 2 | 2 1.5|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Bile Duct, Hyperplasia | 2 2 2 1 1 1 1 2 2 1 | 10 1.5|
Periportal, Inflammation, Chronic | 2 2 2 1 1 1 2 2 2 | 9 1.7|
Periportal, Inflammation, Chronic | | |
Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Atrophy | 1 2 1 | 3 1.3|
Inflammation, Chronic | 1 1 1 1 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Aorta, Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 1 1 1 1 1 1 1 1 2 1 | 10 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| | |
| 4| 4| 4| 4| 2| 4| 4| 2| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.0% | 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Angiectasis | 1 2 | 2 1.5|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
Pars Distalis, Angiectasis | 2 2 2 2 2 | 5 2.0|
Pars Distalis, Cyst | 3 2 2 1 3 2 | 6 2.2|
Pars Intermedia, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 10 |
Inflammation, Chronic | 1 1 1 1 1 2 | 6 1.2|
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Hydrometra | 2 2 | 2 2.0|
Endometrium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Mediastinal, Hemorrhage | 4 | 1 4.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
Pancreatic, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + | 9 |
Hemorrhage | 1 2 3 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + | 9 |
Hemorrhage | 2 1 | 2 1.5|
Infiltration Cellular, Histiocyte | 2 2 1 1 2 1 1 1 2 | 9 1.4|
Pigmentation | 1 1 1 1 1 1 1 1 | 8 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| | |
| 4| 4| 4| 4| 2| 4| 4| 2| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2.0% | 1| 1| 1| 1| 1| 5| 5| 5| 5| 5| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
Depletion Lymphoid | 1 | 1 1.0|
Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + M + M + | 7 |
Hyperplasia | 1 1 2 2 | 4 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Congestion | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 | 7 1.0|
Artery, Mineralization | 1 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy | 2 2 2 2 2 2 2 2 2 4 | 10 2.2|
Renal Tubule, Hyperplasia | 1 3 | 2 2.0|
Renal Tubule, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
Renal Tubule, Pigmentation | 1 2 2 2 2 2 2 2 2 2 | 10 1.9|
Transitional Epithelium, Hyperplasia | 1 | 1 1.0|
Transitional Epithelium, | | |
Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
Transitional Epithelium, Hyperplasia | 1 3 2 1 | 4 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 5| 7| 7| 7| 2| 2| 6| 6| 5| 2| 2| 4| 7| 2| 2| 2| 7| 7| 7| 6| 2|
DAY ON TEST | 3| 9| 5| 7| 8| 3| 3| 0| 7| 7| 6| 4| 5| 7| 7| 5| 3| 7| 7| 7| 3| 3| 2| 5| 7|
| 5| 2| 6| 4| 7| 4| 4| 7| 5| 5| 6| 6| 6| 6| 6| 8| 4| 3| 6| 5| 4| 4| 7| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 71 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + M +|
Autolysis | |
Parasite Metazoan | 1 1 2 1 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | 1 1 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Autolysis | |
Basophilic Focus | 1 1 |
Clear Cell Focus | 1 |
Degeneration | 1 1 2 |
Eosinophilic Focus | |
Fatty Change | 1 3 1 1 |
Fibrosis | |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic, Granulomatous | |
Inflammation, Chronic Active | 1 1 1 |
Mixed Cell Focus | 1 |
Necrosis, Coagulative | 1 |
Pigmentation | 1 1 |
Regeneration | |
Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 1 1 3 1 1 1 1 1 1 3 |
Periportal, Inflammation, Chronic | 1 1 |
Periportal, Inflammation, Chronic | |
Active | 1 1 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 1 2|
Ectopic Tissue | X |
Infiltration Cellular, Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 5| 7| 7| 7| 2| 2| 6| 6| 5| 2| 2| 4| 7| 2| 2| 2| 7| 7| 7| 6| 2|
DAY ON TEST | 3| 9| 5| 7| 8| 3| 3| 0| 7| 7| 6| 4| 5| 7| 7| 5| 3| 7| 7| 7| 3| 3| 2| 5| 7|
| 5| 2| 6| 4| 7| 4| 4| 7| 5| 5| 6| 6| 6| 6| 6| 8| 4| 3| 6| 5| 4| 4| 7| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 71 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Cell | 1 2|
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 1 1 2 |
Necrosis, Coagulative | 1 1 |
Pigmentation | |
Vacuolization Cytoplasmic | 2 1 2 1 1 1 |
Acinus, Atrophy | 2 |
Artery, Polyarteritis | 3 |
Duct, Hyperplasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperkeratosis | 3 3 |
Hyperplasia, Basal Cell | 2 2 |
Hyperplasia, Squamous | 2 |
Inflammation, Chronic Active | |
Ulcer | 4 |
Muscularis, Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Mucosa, Necrosis, Coagulative | 1 |
Muscularis, Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 1 1 1 1 1 1 2 1 2 1 1 2 2 1 1 1 1 1 2 2 1 1|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 |
Necrosis, Coagulative | 2 |
Vacuolization Cytoplasmic | 3 1 2 1 2 2 1 |
Bilateral, Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 1 1 2 2 1 |
Necrosis, Coagulative | 2 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 5| 7| 7| 7| 2| 2| 6| 6| 5| 2| 2| 4| 7| 2| 2| 2| 7| 7| 7| 6| 2|
DAY ON TEST | 3| 9| 5| 7| 8| 3| 3| 0| 7| 7| 6| 4| 5| 7| 7| 5| 3| 7| 7| 7| 3| 3| 2| 5| 7|
| 5| 2| 6| 4| 7| 4| 4| 7| 5| 5| 6| 6| 6| 6| 6| 8| 4| 3| 6| 5| 4| 4| 7| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 71 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + M + + + + + + +|
Pars Distalis, Cyst | 1 1 |
Pars Distalis, Hyperplasia | 2 1 1 2 2 1 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
C-Cell, Hyperplasia | 1 1 1 1 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aspermia | |
Inflammation, Chronic Active | 1 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Abscess | 4 2 2 |
Cyst | |
Inflammation, Chronic | 2 1 1 1 |
Inflammation, Chronic Active | 2 2 2 2 2 1 1 3 2 1 1 1 1 1 1 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Inflammation, Chronic Active | 2 4 2 |
Metaplasia, Squamous | |
Epithelium, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | |
Interstitial Cell, Hyperplasia | 1 1 2 2 1 1 |
Seminiferous Tubule, Atrophy | 4 4 4 4 4 3 3 4 1 4 4 4 4 3 |
Seminiferous Tubule, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Myelofibrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 5| 7| 7| 7| 2| 2| 6| 6| 5| 2| 2| 4| 7| 2| 2| 2| 7| 7| 7| 6| 2|
DAY ON TEST | 3| 9| 5| 7| 8| 3| 3| 0| 7| 7| 6| 4| 5| 7| 7| 5| 3| 7| 7| 7| 3| 3| 2| 5| 7|
| 5| 2| 6| 4| 7| 4| 4| 7| 5| 5| 6| 6| 6| 6| 6| 8| 4| 3| 6| 5| 4| 4| 7| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 71 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + M + + M M + M M M + M + M + M|
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | 1 |
Mediastinal, Sinus, Ectasia | |
Renal, Hemorrhage | |
Renal, Infiltration Cellular, | |
Histiocyte | 4 |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 3 3 1 1 2 3 |
Hyperplasia | 3 2 3 |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +|
Depletion Lymphoid | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 4 1 3 |
Fibrosis | 2 1 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Thymus | + M + + + + M + + + + M M M + + + + + + + + + + +|
Cyst | 1 |
Depletion Lymphoid | 2 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M M + + M + + + + + + + M M + + + M + M M M|
Galactocele | 2 2 |
Hyperplasia | 1 2 1 1 2 4 3 1 2 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Fibrosis | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 1 |
__________________________________________________________________________|
Spinal Cord | + + + |
Infarct | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 5| 7| 7| 7| 2| 2| 6| 6| 5| 2| 2| 4| 7| 2| 2| 2| 7| 7| 7| 6| 2|
DAY ON TEST | 3| 9| 5| 7| 8| 3| 3| 0| 7| 7| 6| 4| 5| 7| 7| 5| 3| 7| 7| 7| 3| 3| 2| 5| 7|
| 5| 2| 6| 4| 7| 4| 4| 7| 5| 5| 6| 6| 6| 6| 6| 8| 4| 3| 6| 5| 4| 4| 7| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 71 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Crystals | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 |
Necrosis, Coagulative | |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Mineralization | |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 |
Artery, Thrombosis | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 3 4 3 2 2 1 4 1 1 2 |
Metaplasia, Squamous | 3 2 3 2 |
Ulcer | 2 2 |
Glands, Hyperplasia | 1 2 1 |
Glands, Inflammation, Acute | |
Glands, Inflammation, Chronic Active | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | M M + M M M M M M|
Acanthosis | |
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Eye | + |
Anterior, Synechia | |
Cornea, Inflammation, Chronic Active | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Cyst | 1 1 |
Cyst, Multiple | 3 |
Granuloma | 2 |
Hydronephrosis | |
Inflammation, Chronic | 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 5| 7| 7| 7| 2| 2| 6| 6| 5| 2| 2| 4| 7| 2| 2| 2| 7| 7| 7| 6| 2|
DAY ON TEST | 3| 9| 5| 7| 8| 3| 3| 0| 7| 7| 6| 4| 5| 7| 7| 5| 3| 7| 7| 7| 3| 3| 2| 5| 7|
| 5| 2| 6| 4| 7| 4| 4| 7| 5| 5| 6| 6| 6| 6| 6| 8| 4| 3| 6| 5| 4| 4| 7| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
D 71 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 4 4 2 3 2 3 3 4 3 3 3 2 4 3 3 3 2 |
Renal Tubule, Hyperplasia | 2 2 2 |
Renal Tubule, Inflammation, Chronic | |
Active | 1 1 1 1 |
Renal Tubule, Mineralization | |
Renal Tubule, Pigmentation | 3 |
Renal Tubule, Regeneration | 1 1 1 1 1 1 1 1|
Transitional Epithelium, Hyperplasia | 2 1 1 1 1 1 2 1 2 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | 3 2 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic Active | |
Serosa, Mineralization | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 4| 6| 4| 2| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 5| 3| 3| 7| 5| 3| 3| 2| 3| 3| 3| 7| 3| 1| 3| 5| 9| 5| 7| 3| 5| 3| 3| 7|
| 4| 6| 4| 5| 1| 6| 4| 5| 1| 5| 4| 5| 9| 1| 4| 4| 8| 6| 6| 6| 4| 6| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 71 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | 1 1 1 1 1 1 1|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + M + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | 1 1 1 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Autolysis | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Autolysis | 3 |
Basophilic Focus | 1 1 1 1 2 |
Clear Cell Focus | 1 |
Degeneration | 1 1 2 1 1 1 1 |
Eosinophilic Focus | 1 |
Fatty Change | 1 1 1 3 1 1 1 1 2 1 |
Fibrosis | |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | 2 X |
Inflammation, Chronic, Granulomatous | 1 1 |
Inflammation, Chronic Active | 1 1 1 |
Mixed Cell Focus | |
Necrosis, Coagulative | 1 1 1 1 1 |
Pigmentation | 1 |
Regeneration | 2 3 3 |
Bile Duct, Hyperplasia | 1 1 1 1 2 2 2 2 1 1 1 1 2 2 1 1 1 1 2 1 2 1 1|
Periportal, Inflammation, Chronic | 1 1 1 1 1 |
Periportal, Inflammation, Chronic | |
Active | 1 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 |
Ectopic Tissue | |
Infiltration Cellular, Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 4| 6| 4| 2| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 5| 3| 3| 7| 5| 3| 3| 2| 3| 3| 3| 7| 3| 1| 3| 5| 9| 5| 7| 3| 5| 3| 3| 7|
| 4| 6| 4| 5| 1| 6| 4| 5| 1| 5| 4| 5| 9| 1| 4| 4| 8| 6| 6| 6| 4| 6| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 71 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Cell | |
Inflammation, Chronic | 1 1 1 1 1 |
Inflammation, Chronic Active | 1 1 1 |
Necrosis, Coagulative | |
Pigmentation | |
Vacuolization Cytoplasmic | 1 1 1 2 1|
Acinus, Atrophy | |
Artery, Polyarteritis | 2 4 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 2 1|
Hyperplasia, Basal Cell | 3 1 1 2 1 |
Hyperplasia, Squamous | 2 1|
Inflammation, Chronic Active | 2 3 1|
Ulcer | 2 2 |
Muscularis, Mineralization | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
Mucosa, Necrosis, Coagulative | |
Muscularis, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 1 2 1 1 3 2 2 1 2 1 1 3 1 2 1 2 2 1|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Hematopoietic Cell Proliferation | 1 1 |
Hyperplasia | 2 2 2 |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 1 2 1 2 1 3 1 2 1|
Bilateral, Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 2 2 3 1 1 1 |
Necrosis, Coagulative | |
Bilateral, Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 4| 6| 4| 2| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 5| 3| 3| 7| 5| 3| 3| 2| 3| 3| 3| 7| 3| 1| 3| 5| 9| 5| 7| 3| 5| 3| 3| 7|
| 4| 6| 4| 5| 1| 6| 4| 5| 1| 5| 4| 5| 9| 1| 4| 4| 8| 6| 6| 6| 4| 6| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 71 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + M + + M + + + + + M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + I + + + + M + + + + + + + +|
Pars Distalis, Cyst | 1 1 2 1 |
Pars Distalis, Hyperplasia | 1 1 1 1 2 1 1 1 |
Pars Intermedia, Cyst | 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Chronic Active | 1 |
C-Cell, Hyperplasia | 1 1 1 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aspermia | |
Inflammation, Chronic Active | 1 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Abscess | 1 3 2 |
Cyst | 3 |
Inflammation, Chronic | 2 1 |
Inflammation, Chronic Active | 2 2 2 2 2 2 3 2 3 1 2 2 1 2 2 2 1 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Inflammation, Chronic Active | 3 4 1 4 3 3 2 2 |
Metaplasia, Squamous | 2 |
Epithelium, Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + M + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | 2 |
Interstitial Cell, Hyperplasia | 2 1 2 1 1 2 1 1 1 1 1|
Seminiferous Tubule, Atrophy | 3 4 4 2 4 4 4 4 4 2 3 4 4 1 4 4 4 1|
Seminiferous Tubule, Mineralization | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Myelofibrosis | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 4| 6| 4| 2| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 5| 3| 3| 7| 5| 3| 3| 2| 3| 3| 3| 7| 3| 1| 3| 5| 9| 5| 7| 3| 5| 3| 3| 7|
| 4| 6| 4| 5| 1| 6| 4| 5| 1| 5| 4| 5| 9| 1| 4| 4| 8| 6| 6| 6| 4| 6| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 71 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | M + + + + + + |
Mediastinal, Hemorrhage | 3 1 |
Mediastinal, Pigmentation | |
Mediastinal, Sinus, Ectasia | |
Renal, Hemorrhage | 2 |
Renal, Infiltration Cellular, | |
Histiocyte | |
Renal, Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 3 |
Hyperplasia | 3 3 2 3 2 |
Infiltration Cellular, Histiocyte | 1 1|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 2 4 3 4 2 |
Fibrosis | 3 2 |
Necrosis, Coagulative | 4 2 |
__________________________________________________________________________|
Thymus | + + M + M + + + + M + + + + + + + M + + + + + + +|
Cyst | 2 1 |
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + M M + + + + M M + + M M M M + M|
Galactocele | 2 |
Hyperplasia | 4 2 3 1 1 2 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 3 |
Fibrosis | 2 |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
__________________________________________________________________________|
Spinal Cord | + |
Infarct | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 4| 6| 4| 2| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 5| 3| 3| 7| 5| 3| 3| 2| 3| 3| 3| 7| 3| 1| 3| 5| 9| 5| 7| 3| 5| 3| 3| 7|
| 4| 6| 4| 5| 1| 6| 4| 5| 1| 5| 4| 5| 9| 1| 4| 4| 8| 6| 6| 6| 4| 6| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 71 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Crystals | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1|
Necrosis, Coagulative | |
Alveolar Epithelium, Hyperplasia | 2 1 1 2 1|
Alveolus, Mineralization | 1 |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Artery, Thrombosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic Active | 1 1 2 3 3 3 1 2 3 3 2|
Metaplasia, Squamous | 1 2 2 1|
Ulcer | |
Glands, Hyperplasia | 1 2 1 1 2 1 |
Glands, Inflammation, Acute | 1 1 |
Glands, Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 |
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + M |
Acanthosis | 2 |
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell | 2 |
Inflammation, Chronic Active | 1 |
Ulcer | |
__________________________________________________________________________|
Eye | I + + |
Anterior, Synechia | |
Cornea, Inflammation, Chronic Active | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 3 |
Cyst | 1 |
Cyst, Multiple | |
Granuloma | |
Hydronephrosis | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 4| 6| 4| 2| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 5| 3| 3| 7| 5| 3| 3| 2| 3| 3| 3| 7| 3| 1| 3| 5| 9| 5| 7| 3| 5| 3| 3| 7|
| 4| 6| 4| 5| 1| 6| 4| 5| 1| 5| 4| 5| 9| 1| 4| 4| 8| 6| 6| 6| 4| 6| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
UNTREATE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
D 71 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 3 2 4 3 3 2 3 2 2 2 3 4 2 2 2 4 2 3 2 2 2 3 3 2|
Renal Tubule, Hyperplasia | 4 |
Renal Tubule, Inflammation, Chronic | |
Active | 1 1 1 1 |
Renal Tubule, Mineralization | |
Renal Tubule, Pigmentation | 2 2 1 2 |
Renal Tubule, Regeneration | 1 |
Transitional Epithelium, Hyperplasia | 1 2 2 2 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Hemorrhage | |
Hyperplasia, Lymphoid | 1 1 1 |
Inflammation, Chronic Active | |
Serosa, Mineralization | 1 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 4| 7| 4| 7| 5| 4| 7| 7| 4| 5| 2| 7| 7| 7| 7| 5| | |
DAY ON TEST | 5| 3| 2| 4| 2| 3| 2| 3| 7| 5| 3| 3| 5| 7| 7| 3| 3| 3| 3| 6| | |
| 8| 4| 1| 9| 1| 4| 7| 4| 4| 6| 1| 1| 6| 3| 5| 4| 1| 3| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
D 71 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + | 67 |
Autolysis | | 1 3.0|
Parasite Metazoan | 1 1 2 1 1 1 | 19 1.1|
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + M + A + + + + + + + + + + + + + + + | 65 |
Autolysis | | 1 3.0|
Parasite Metazoan | 1 | 7 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + | 68 |
Autolysis | 2 | 2 2.5|
Parasite Metazoan | | 7 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + | 68 |
Autolysis | 3 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + | 68 |
Autolysis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + | 68 |
Autolysis | 3 2 | 3 2.7|
Hyperplasia, Lymphoid | | 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | | 3 1.3|
Autolysis | 1 | 2 2.0|
Basophilic Focus | 1 1 1 | 10 1.1|
Clear Cell Focus | 1 | 3 1.0|
Degeneration | 1 1 | 12 1.2|
Eosinophilic Focus | 1 | 2 1.0|
Fatty Change | 1 1 | 16 1.3|
Fibrosis | 1 | 1 1.0|
Hematopoietic Cell Proliferation | | 2 1.0|
Hepatodiaphragmatic Nodule | X | 3 2.0|
Inflammation, Chronic, Granulomatous | | 2 1.0|
Inflammation, Chronic Active | 1 1 1 1 | 10 1.0|
Mixed Cell Focus | 1 | 2 1.0|
Necrosis, Coagulative | 1 2 1 2 | 10 1.2|
Pigmentation | | 3 1.0|
Regeneration | 3 | 4 2.8|
Bile Duct, Hyperplasia | 1 1 3 2 1 2 1 1 2 1 2 1 2 1 1 1 | 56 1.4|
Periportal, Inflammation, Chronic | 1 1 1 | 10 1.0|
Periportal, Inflammation, Chronic | | |
Active | 1 1 1 | 11 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 4| 7| 4| 7| 5| 4| 7| 7| 4| 5| 2| 7| 7| 7| 7| 5| | |
DAY ON TEST | 5| 3| 2| 4| 2| 3| 2| 3| 7| 5| 3| 3| 5| 7| 7| 3| 3| 3| 3| 6| | |
| 8| 4| 1| 9| 1| 4| 7| 4| 4| 6| 1| 1| 6| 3| 5| 4| 1| 3| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
D 71 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
Atrophy | 2 1 2 1 2 1 1 1 | 17 1.4|
Ectopic Tissue | | 1 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 3 1.3|
Inflammation, Chronic | 1 1 | 9 1.0|
Inflammation, Chronic Active | 1 1 1 2 1 | 11 1.2|
Necrosis, Coagulative | | 2 1.0|
Pigmentation | 1 | 1 1.0|
Vacuolization Cytoplasmic | 1 1 1 1 1 1 | 17 1.2|
Acinus, Atrophy | | 1 2.0|
Artery, Polyarteritis | 3 | 4 3.0|
Duct, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 69 |
Hyperkeratosis | | 5 2.4|
Hyperplasia, Basal Cell | 1 1 1 1 | 11 1.5|
Hyperplasia, Squamous | | 3 1.7|
Inflammation, Chronic Active | | 3 2.0|
Ulcer | | 3 2.7|
Muscularis, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 2 1 | 3 1.3|
Mucosa, Necrosis, Coagulative | | 1 1.0|
Muscularis, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Cardiomyopathy | 2 2 2 2 2 1 2 2 1 1 2 2 2 2 2 2 2 2 | 66 1.6|
Thrombosis | 4 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis | 3 | 2 2.0|
Hematopoietic Cell Proliferation | | 2 1.0|
Hyperplasia | 2 | 5 2.0|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 4| 7| 4| 7| 5| 4| 7| 7| 4| 5| 2| 7| 7| 7| 7| 5| | |
DAY ON TEST | 5| 3| 2| 4| 2| 3| 2| 3| 7| 5| 3| 3| 5| 7| 7| 3| 3| 3| 3| 6| | |
| 8| 4| 1| 9| 1| 4| 7| 4| 4| 6| 1| 1| 6| 3| 5| 4| 1| 3| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
D 71 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Vacuolization Cytoplasmic | 1 1 1 2 2 1 2 | 23 1.6|
Bilateral, Vacuolization Cytoplasmic | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + | 69 |
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | 2 2 2 2 2 2 | 18 1.7|
Necrosis, Coagulative | 4 | 2 3.0|
Bilateral, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + | 54 |
Hemorrhage | | 1 1.0|
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + | 63 |
Hyperplasia | 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 65 |
Pars Distalis, Cyst | 1 | 7 1.1|
Pars Distalis, Hyperplasia | 1 1 1 1 1 1 1 2 | 23 1.3|
Pars Intermedia, Cyst | | 2 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
Inflammation, Chronic Active | 1 | 2 1.0|
C-Cell, Hyperplasia | 1 1 | 11 1.0|
Follicle, Cyst | 2 2 | 2 2.0|
Follicular Cell, Hyperplasia | | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 2 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 |
Aspermia | 4 | 1 4.0|
Inflammation, Chronic Active | 1 | 3 1.0|
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + M + + + + + + + + + + | 67 |
Abscess | | 6 2.3|
Cyst | 3 | 2 3.0|
Inflammation, Chronic | 2 | 7 1.4|
Inflammation, Chronic Active | 2 2 1 1 1 1 1 2 2 3 2 2 1 1 3 2 1 1 | 57 1.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 4| 7| 4| 7| 5| 4| 7| 7| 4| 5| 2| 7| 7| 7| 7| 5| | |
DAY ON TEST | 5| 3| 2| 4| 2| 3| 2| 3| 7| 5| 3| 3| 5| 7| 7| 3| 3| 3| 3| 6| | |
| 8| 4| 1| 9| 1| 4| 7| 4| 4| 6| 1| 1| 6| 3| 5| 4| 1| 3| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
D 71 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Acute | | 2 1.0|
Inflammation, Chronic Active | 1 1 2 2 3 2 | 17 2.4|
Metaplasia, Squamous | | 1 2.0|
Epithelium, Hyperplasia | 1 | 8 1.1|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 69 |
Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
Polyarteritis | | 1 2.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 2 1 2 1 1 1 | 27 1.3|
Seminiferous Tubule, Atrophy | 3 4 3 4 4 3 1 4 4 4 4 | 43 3.4|
Seminiferous Tubule, Mineralization | 2 1 | 8 1.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Sternal, Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + M + | 19 |
Mediastinal, Hemorrhage | | 2 2.0|
Mediastinal, Pigmentation | | 1 1.0|
Mediastinal, Sinus, Ectasia | 2 | 1 2.0|
Renal, Hemorrhage | | 1 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 1 4.0|
Renal, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemorrhage | 1 3 3 | 12 2.1|
Hyperplasia | 1 2 2 | 11 2.4|
Infiltration Cellular, Histiocyte | | 2 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 68 |
Depletion Lymphoid | | 1 3.0|
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | 2 1 2 1 1 1 1 2 1 1 1 2 1 1 1 1 1 1 | 64 1.1|
Pigmentation | 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Depletion Lymphoid | 3 4 2 | 12 2.9|
Fibrosis | 2 1 | 6 1.8|
Necrosis, Coagulative | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + M + + + M + + + + M M + + | 56 |
Cyst | | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 4| 7| 4| 7| 5| 4| 7| 7| 4| 5| 2| 7| 7| 7| 7| 5| | |
DAY ON TEST | 5| 3| 2| 4| 2| 3| 2| 3| 7| 5| 3| 3| 5| 7| 7| 3| 3| 3| 3| 6| | |
| 8| 4| 1| 9| 1| 4| 7| 4| 4| 6| 1| 1| 6| 3| 5| 4| 1| 3| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
D 71 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Depletion Lymphoid | | 3 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M + M + + + + M M M M M + M M + + M | 39 |
Galactocele | | 3 2.0|
Hyperplasia | 2 1 1 2 | 25 1.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst Epithelial Inclusion | | 1 3.0|
Fibrosis | | 1 2.0|
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Infarct | 3 | 3 1.7|
__________________________________________________________________________|____________|
Spinal Cord | + | 5 |
Infarct | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Crystals | | 1 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 | 24 1.0|
Necrosis, Coagulative | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 7 1.6|
Alveolus, Mineralization | | 1 1.0|
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 | 36 1.0|
Artery, Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + M + + | 68 |
Autolysis | | 1 3.0|
Inflammation, Chronic Active | 2 1 4 2 4 | 26 2.3|
Metaplasia, Squamous | 2 2 | 10 2.0|
Ulcer | | 2 2.0|
Glands, Hyperplasia | | 9 1.3|
Glands, Inflammation, Acute | 1 | 3 1.0|
Glands, Inflammation, Chronic Active | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 4| 7| 4| 7| 5| 4| 7| 7| 4| 5| 2| 7| 7| 7| 7| 5| | |
DAY ON TEST | 5| 3| 2| 4| 2| 3| 2| 3| 7| 5| 3| 3| 5| 7| 7| 3| 3| 3| 3| 6| | |
| 8| 4| 1| 9| 1| 4| 7| 4| 4| 6| 1| 1| 6| 3| 5| 4| 1| 3| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
UNTREATE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
D 71 UM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Chronic Active | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 4 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 2.0|
Hyperplasia, Basal Cell | | 1 2.0|
Inflammation, Chronic Active | 2 | 2 1.5|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Eye | + + + | 6 |
Anterior, Synechia | 4 | 1 4.0|
Cornea, Inflammation, Chronic Active | 3 | 1 3.0|
Retina, Degeneration | 4 | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | | 2 3.0|
Cyst | 1 | 4 1.0|
Cyst, Multiple | | 1 3.0|
Granuloma | | 1 2.0|
Hydronephrosis | 1 | 1 1.0|
Inflammation, Chronic | | 4 1.0|
Nephropathy | 2 4 3 3 1 3 2 3 3 2 3 3 2 2 3 3 4 2 2 | 60 2.7|
Renal Tubule, Hyperplasia | 1 1 1 3 4 | 9 2.2|
Renal Tubule, Inflammation, Chronic | | |
Active | 1 1 1 1 1 1 | 14 1.0|
Renal Tubule, Mineralization | 2 | 1 2.0|
Renal Tubule, Pigmentation | | 5 2.0|
Renal Tubule, Regeneration | 1 | 10 1.0|
Transitional Epithelium, Hyperplasia | 2 1 2 2 2 1 1 1 | 30 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 70 |
Calculus Micro Observation Only | | 2 2.5|
Hemorrhage | 4 | 2 3.0|
Hyperplasia, Lymphoid | | 4 1.3|
Inflammation, Chronic Active | 1 | 1 1.0|
Serosa, Mineralization | | 1 1.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 7| 0| 7| 3| 3| 1| 5| 1| 3| 3| 3| 2| 9| 3| 3| 3| 2| 7| 3| 3| 3| 3| 7|
| 1| 1| 3| 4| 6| 4| 4| 8| 3| 8| 4| 4| 4| 0| 3| 1| 1| 1| 9| 6| 1| 1| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Parasite Metazoan | 1 X 1 1 1 1 1 1 1 1 |
Polyarteritis | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic Active | 2 |
Parasite Metazoan | 1 1 1 1 1 1 |
Ulcer, Acute | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | M + + + + + + + + + + + + + + + M + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 1 2 1 1 2 4 3 1 1 |
Clear Cell Focus | 1 1 2 2 1 1 2 2 2 3 1 4 2 |
Degeneration | 1 |
Eosinophilic Focus | 4 3 4 4 2 4 |
Fatty Change | 1 1 1 1 1 |
Hepatodiaphragmatic Nodule | X |
Infarct | |
Inflammation, Chronic Active | 1 |
Mixed Cell Focus | 1 4 1 4 4 3 3 |
Necrosis, Coagulative | 1 3 1 1|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Bile Duct, Cyst | 3 |
Bile Duct, Hyperplasia | 1 1 1 1 |
Periportal, Inflammation, Chronic | |
Active | 1 1 1 1|
__________________________________________________________________________|
Mesentery | M M M|
Fibrosis | |
Inflammation, Chronic, Granulomatous | |
Inflammation, Chronic Active | |
Necrosis, Coagulative | |
Polyarteritis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 2 1 2 1 2 1 1 3 1 2 3 2 1 2 1 2|
Infiltration Cellular, Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 7| 0| 7| 3| 3| 1| 5| 1| 3| 3| 3| 2| 9| 3| 3| 3| 2| 7| 3| 3| 3| 3| 7|
| 1| 1| 3| 4| 6| 4| 4| 8| 3| 8| 4| 4| 4| 0| 3| 1| 1| 1| 9| 6| 1| 1| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Cell | 1 1|
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 |
Vacuolization Cytoplasmic | 1 |
Artery, Polyarteritis | 4 2 4 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 2 2 2 2 1 2 2 2 |
Hyperplasia, Basal Cell | 2 2 2 2 2 2 2 2 2 2 |
Hyperplasia, Squamous | 3 3 3 3 3 2 4 4 2 3 3 |
Inflammation, Chronic Active | 1 1 3 2 4 2 2 4 |
Ulcer | 4 3 4 4 2 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Cardiomyopathy | 2 3 2 1 2 1 3 2 1 3 2 1 2 2 2 2 2 1 1 2 1 1 2 |
Polyarteritis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 |
Hyperplasia | 1 |
Vacuolization Cytoplasmic | 2 2 1 1 2 1 2 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 2 2 1 2 2 1 1 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + M + M + + + + + + + + M + + +|
Hyperplasia | 2 2 2 1 2 2 2 1 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 2 2 |
Pars Distalis, Hyperplasia | 2 1 1 1 1 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | |
Inflammation, Chronic Active | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 2 1 |
Follicle, Cyst | 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 7| 0| 7| 3| 3| 1| 5| 1| 3| 3| 3| 2| 9| 3| 3| 3| 2| 7| 3| 3| 3| 3| 7|
| 1| 1| 3| 4| 6| 4| 4| 8| 3| 8| 4| 4| 4| 0| 3| 1| 1| 1| 9| 6| 1| 1| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 4 1 2 3 3 2 4 4 |
Metaplasia, Squamous | 4 2 4 |
Polyarteritis | |
Epithelium, Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 2 2 2 2 2 3 2 3 3 3 3 3 3 |
Inflammation, Chronic Active | 4 4 |
Metaplasia, Squamous | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Mineralization | |
Interstitial Cell, Hyperplasia | 1 1 1 1|
Seminiferous Tubule, Atrophy | 4 4 4 3 4 4 4 3 2 4 4 4 4 4 4 4 4 3 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + M + + + M |
Lumbar, Hyperplasia | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Hyperplasia | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 1 1 |
Renal, Hemorrhage | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 1|
Hyperplasia | 2 2 2 2 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 1 |
Fibrosis | 2 1 |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 7| 0| 7| 3| 3| 1| 5| 1| 3| 3| 3| 2| 9| 3| 3| 3| 2| 7| 3| 3| 3| 3| 7|
| 1| 1| 3| 4| 6| 4| 4| 8| 3| 8| 4| 4| 4| 0| 3| 1| 1| 1| 9| 6| 1| 1| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + M + + + + + M + + + M M + + M M + + + + + +|
Depletion Lymphoid | 2 2 |
Hemorrhage | 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + M M + M M + M + M M + M + + + M + + M + +|
Galactocele | 2 |
Hyperplasia | 2 2 1 2 2 2 2 2 1 3 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + I + + + I + + + + + + + + +|
Abscess | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Rib, Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
Polyarteritis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + |
Infarct | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 1|
Artery, Mineralization | 1 1 1 1 1 1 1 1 |
Mediastinum, Polyarteritis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic Active | 1 3 4 1 4 2 3 4 4 3 4 1 1 1 |
Metaplasia, Squamous | 2 2 2 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + + + + |
Acanthosis | 2 |
Hyperplasia, Basal Cell | 2 |
__________________________________________________________________________|
Eye | I |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 7| 7| 7| 2|
DAY ON TEST | 3| 3| 7| 0| 7| 3| 3| 1| 5| 1| 3| 3| 3| 2| 9| 3| 3| 3| 2| 7| 3| 3| 3| 3| 7|
| 1| 1| 3| 4| 6| 4| 4| 8| 3| 8| 4| 4| 4| 0| 3| 1| 1| 1| 9| 6| 1| 1| 1| 1| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Fibrosis, Focal | |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1|
Nephropathy | 3 4 4 3 2 4 4 4 4 3 4 3 4 4 4 3 4 4 4 4 3 4 |
Renal Tubule, Degeneration, Hyaline | 2 2 2|
Renal Tubule, Hyperplasia | 4 3 1 4 4 4 4 4 4 4 2 3 2 4 |
Renal Tubule, Hyperplasia, Oncocytic | |
Renal Tubule, Inflammation, Chronic | |
Active | 1 1 1 1 |
Renal Tubule, Mineralization | 2 |
Renal Tubule, Pigmentation | 2 2 2 2 1 2 2 2 2 1 2 2 2 2 2 1 1 2 2 1 2 2 2 2 1|
Renal Tubule, Regeneration | 1 1 1|
Transitional Epithelium, Hyperplasia | 2 2 3 2 2 2 2 1 1 2 2 4 4 2 1 2 2 4 1 2 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + M + + + + + + +|
Edema | 3 |
Fibrosis | 1 |
Inflammation, Chronic Active | 2 |
Polyarteritis | |
Transitional Epithelium, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 6| 6| 2| 2| 2| 7| 7| 7| 7| 7| 7| 6| 6| 2| 2| |
DAY ON TEST | 3| 0| 7| 5| 7| 3| 3| 3| 7| 7| 5| 4| 7| 7| 7| 3| 3| 3| 3| 3| 3| 9| 6| 7| 7| |
| 1| 0| 4| 9| 6| 4| 4| 4| 5| 4| 0| 0| 6| 5| 4| 1| 1| 0| 0| 0| 4| 4| 8| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.2% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Autolysis | | 1 2.0|
Parasite Metazoan | 1 1 1 1 1 1 1 | 17 1.0|
Polyarteritis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 1 1 1 1 1 | 8 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Autolysis | | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
Parasite Metazoan | 1 1 | 8 1.0|
Ulcer, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Autolysis | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Autolysis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Autolysis | | 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 2 1 | 3 2.0|
Basophilic Focus | 1 2 | 12 1.7|
Clear Cell Focus | 2 2 2 1 1 2 1 1 3 2 2 2 3 | 26 1.8|
Degeneration | 2 2 | 3 1.7|
Eosinophilic Focus | 1 3 2 2 3 4 2 | 13 2.9|
Fatty Change | 1 1 1 1 1 1| 11 1.0|
Hepatodiaphragmatic Nodule | X | 2 |
Infarct | 3 | 1 3.0|
Inflammation, Chronic Active | | 1 1.0|
Mixed Cell Focus | 2 4 2 1 2 2 2 4 1 2 | 17 2.5|
Necrosis, Coagulative | 1 1 3 1 | 8 1.5|
Pigmentation | 1 1 1 1 1 2 2 | 20 1.1|
Bile Duct, Cyst | | 1 3.0|
Bile Duct, Hyperplasia | 2 1 1 1 1 1 | 10 1.1|
Periportal, Inflammation, Chronic | | |
Active | 1 1 1 1 1 1 1 1| 12 1.0|
__________________________________________________________________________|____________|
Mesentery | + M + + M M M M M| 3 |
Fibrosis | 2 2 | 2 2.0|
Inflammation, Chronic, Granulomatous | 3 | 1 3.0|
Inflammation, Chronic Active | 2 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 6| 6| 2| 2| 2| 7| 7| 7| 7| 7| 7| 6| 6| 2| 2| |
DAY ON TEST | 3| 0| 7| 5| 7| 3| 3| 3| 7| 7| 5| 4| 7| 7| 7| 3| 3| 3| 3| 3| 3| 9| 6| 7| 7| |
| 1| 0| 4| 9| 6| 4| 4| 4| 5| 4| 0| 0| 6| 5| 4| 1| 1| 0| 0| 0| 4| 4| 8| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.2% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Necrosis, Coagulative | 3 3 | 2 3.0|
Polyarteritis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 2 1 2 2 3 1 | 27 1.7|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 | 5 1.0|
Infiltration Cellular, Mixed Cell | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 2 2 1 1 | 28 1.1|
Vacuolization Cytoplasmic | 1 | 2 1.0|
Artery, Polyarteritis | 4 4 4 3 | 8 3.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Hyperkeratosis | 2 2 1 2 2 1 2 2 | 18 1.8|
Hyperplasia, Basal Cell | 2 2 2 1 2 1 3 2 | 18 1.9|
Hyperplasia, Squamous | 3 3 3 1 3 3 4 4 | 19 3.0|
Inflammation, Chronic Active | 3 2 2 3 | 12 2.4|
Ulcer | 2 3 2 4 | 10 3.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Autolysis | 2 | 1 2.0|
Cardiomyopathy | 3 2 3 1 2 2 2 2 1 2 1 1 2 1 1 1 2 2 2 2 2 1 1| 46 1.7|
Polyarteritis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 1 | 5 1.2|
Hyperplasia | | 1 1.0|
Vacuolization Cytoplasmic | 1 2 2 1 2 1 1 1 2 | 18 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 1 2 1 1 1 1 2 3 2 2 | 25 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + | 40 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 45 |
Hyperplasia | 2 2 2 | 12 1.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 1 | 4 1.5|
Pars Distalis, Hyperplasia | 2 1 1 1 1 2 1 2 1 2| 15 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 6| 6| 2| 2| 2| 7| 7| 7| 7| 7| 7| 6| 6| 2| 2| |
DAY ON TEST | 3| 0| 7| 5| 7| 3| 3| 3| 7| 7| 5| 4| 7| 7| 7| 3| 3| 3| 3| 3| 3| 9| 6| 7| 7| |
| 1| 0| 4| 9| 6| 4| 4| 4| 5| 4| 0| 0| 6| 5| 4| 1| 1| 0| 0| 0| 4| 4| 8| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.2% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Intermedia, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 1 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Ultimobranchial Cyst | 2 1 1| 3 1.3|
C-Cell, Hyperplasia | 1 1 1 1 | 8 1.1|
Follicle, Cyst | | 1 1.0|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 2 |
Inflammation, Chronic Active | 3 | 2 3.5|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Abscess | 4 | 1 4.0|
Inflammation, Chronic Active | 2 2 2 2 1 2 2 1 2 2 2 1 1 2 2 1 2 2 2 2 2 1 1| 44 1.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 3 | 3 3.7|
Inflammation, Acute | 2 3| 2 2.5|
Inflammation, Chronic Active | 2 1 2 2 3 1 2 2 2 2 2 4 2 | 22 2.4|
Metaplasia, Squamous | 1 1 1 1 2 3 4 3 | 11 2.4|
Polyarteritis | 3 | 1 3.0|
Epithelium, Hyperplasia | 1 | 4 1.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 3 3 3 3 2 3 3 3 3 4 3 2 | 30 2.7|
Inflammation, Chronic Active | 2 | 3 3.3|
Metaplasia, Squamous | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 3 | 1 3.0|
Mineralization | 1 | 1 1.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1| 12 1.0|
Seminiferous Tubule, Atrophy | 3 4 4 4 4 4 4 3 3 4 4 3 4 4 4 3 | 37 3.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 6| 6| 2| 2| 2| 7| 7| 7| 7| 7| 7| 6| 6| 2| 2| |
DAY ON TEST | 3| 0| 7| 5| 7| 3| 3| 3| 7| 7| 5| 4| 7| 7| 7| 3| 3| 3| 3| 3| 3| 9| 6| 7| 7| |
| 1| 0| 4| 9| 6| 4| 4| 4| 5| 4| 0| 0| 6| 5| 4| 1| 1| 0| 0| 0| 4| 4| 8| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.2% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + M + M M M M M| 6 |
Lumbar, Hyperplasia | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 1 | 1 1.0|
Pancreatic, Hyperplasia | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 2 1.0|
Renal, Hemorrhage | 1 | 1 1.0|
Renal, Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1 | 5 1.2|
Hyperplasia | 2 2 | 7 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| 50 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | 2 | 3 1.7|
Fibrosis | 2 | 3 1.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + M + + + + + + + + M + +| 41 |
Depletion Lymphoid | 2 3| 4 2.3|
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + M M M M + + M + + + + + + M M + + M M +| 29 |
Galactocele | | 1 2.0|
Hyperplasia | 1 1 1 2 2 2 1 1 1 2 1 2 2 1| 25 1.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Abscess | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Rib, Hyperostosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Polyarteritis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 6| 6| 2| 2| 2| 7| 7| 7| 7| 7| 7| 6| 6| 2| 2| |
DAY ON TEST | 3| 0| 7| 5| 7| 3| 3| 3| 7| 7| 5| 4| 7| 7| 7| 3| 3| 3| 3| 3| 3| 9| 6| 7| 7| |
| 1| 0| 4| 9| 6| 4| 4| 4| 5| 4| 0| 0| 6| 5| 4| 1| 1| 0| 0| 0| 4| 4| 8| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.2% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Infarct | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 | 23 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 2 1.0|
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 | 17 1.0|
Mediastinum, Polyarteritis | 4 2 | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 1 | 2 1.5|
Inflammation, Chronic Active | 1 2 1 1 3 2 4 2 2 3 1 | 25 2.3|
Metaplasia, Squamous | 2 3 | 7 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 7 |
Acanthosis | | 1 2.0|
Hyperplasia, Basal Cell | | 1 2.0|
__________________________________________________________________________|____________|
Eye | + + + | 3 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 3 2.0|
Fibrosis, Focal | 3 | 1 3.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 1 1 1 1| 9 1.0|
Nephropathy | 4 4 4 3 4 3 4 4 4 4 3 3 3 4 3 3 4 4 | 40 3.6|
Renal Tubule, Degeneration, Hyaline | 2 2 2 2 2 2 2| 10 2.0|
Renal Tubule, Hyperplasia | 3 2 2 3 2 2 3 3 3 4 1 3 1 3 2 1 | 30 2.8|
Renal Tubule, Hyperplasia, Oncocytic | 2 | 1 2.0|
Renal Tubule, Inflammation, Chronic | | |
Active | 1 1 1 1 1 1 | 10 1.0|
Renal Tubule, Mineralization | 1 | 2 1.5|
Renal Tubule, Pigmentation | 2 2 2 2 1 2 2 2 2 1 2 2 1 2 1 2 2 2 2 2 2 2 2 1 1| 50 1.8|
Renal Tubule, Regeneration | 2 1 2 2 1 2 2| 10 1.5|
Transitional Epithelium, Hyperplasia | 2 2 2 2 1 1 2 2 2 2 2 2 1 3 3 3 2 2 | 40 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 2| 7| 7| 7| 6| 2| 6| 6| 2| 2| 2| 7| 7| 7| 7| 7| 7| 6| 6| 2| 2| |
DAY ON TEST | 3| 0| 7| 5| 7| 3| 3| 3| 7| 7| 5| 4| 7| 7| 7| 3| 3| 3| 3| 3| 3| 9| 6| 7| 7| |
| 1| 0| 4| 9| 6| 4| 4| 4| 5| 4| 0| 0| 6| 5| 4| 1| 1| 0| 0| 0| 4| 4| 8| 4| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0.2% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| L |
71LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
Edema | | 1 3.0|
Fibrosis | | 1 1.0|
Inflammation, Chronic Active | 1 2 | 3 1.7|
Polyarteritis | 1 | 1 1.0|
Transitional Epithelium, Hyperplasia | 2 2 | 5 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 5| 2| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2|
DAY ON TEST | 2| 2| 2| 6| 5| 2| 1| 2| 7| 7| 2| 2| 9| 7| 7| 2| 2| 2| 1| 5| 2| 2| 2| 0| 7|
| 9| 9| 0| 1| 3| 9| 2| 1| 4| 4| 9| 9| 3| 4| 6| 9| 9| 9| 4| 0| 9| 9| 3| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 2 2 |
Hyperplasia, Lymphoid | 2 |
Parasite Metazoan | 1 1 1 1 1 |
Polyarteritis | 2 |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + + + + + +|
Atypia Cellular | |
Inflammation, Chronic Active | |
Parasite Metazoan | 1 1 2 1 |
Artery, Neovascularization | 2 |
Artery, Thrombosis | 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
Autolysis | 3 2 |
Hyperplasia, Lymphoid | 2 |
Parasite Metazoan | 1 1 1 1 |
Lymphoid Tissue, Hemorrhage | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 1 4 |
Ectopic Tissue | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Autolysis | 1 4 1 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + M + + + + + + + + + + + + + + + + + +|
Autolysis | 1 1 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 2 1 1 4 2 1 1 |
Clear Cell Focus | 1 3 2 1 1 3 2 1 1 1 1 2 1 4 1 |
Cyst | |
Degeneration | 1 1 1 1 |
Eosinophilic Focus | 2 1 4 1 3 3 3 |
Fatty Change | 2 1 1 1|
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Infarct | |
Inflammation, Chronic Active | |
Mixed Cell Focus | 2 2 3 |
Necrosis, Coagulative | 1 1 3 3 |
Pigmentation | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Bile Duct, Hyperplasia | 2 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 |
Periportal, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 5| 2| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2|
DAY ON TEST | 2| 2| 2| 6| 5| 2| 1| 2| 7| 7| 2| 2| 9| 7| 7| 2| 2| 2| 1| 5| 2| 2| 2| 0| 7|
| 9| 9| 0| 1| 3| 9| 2| 1| 4| 4| 9| 9| 3| 4| 6| 9| 9| 9| 4| 0| 9| 9| 3| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Active | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | + + |
Fibrosis | 2 4 |
Hemorrhage | |
Inflammation, Chronic Active | 2 2 |
Necrosis, Coagulative | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 2 2 2 1 1 1 |
Autolysis | 2 |
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 |
Vacuolization Cytoplasmic | 2 1 2 |
Acinus, Hyperplasia | |
Artery, Fibrosis | 4 |
Artery, Polyarteritis | 4 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Inflammation, Chronic | 1 |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 |
Submandibular Gland, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Fibrosis | |
Hyperkeratosis | 2 2 2 2 2 1 |
Hyperplasia, Basal Cell | 2 2 1 1 1 1 2 2 |
Hyperplasia, Squamous | 4 3 3 3 4 3 3 |
Infarct | 4 |
Inflammation, Chronic Active | 2 2 2 |
Ulcer | 3 2 3 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 1 1 2 1 3 1 2 1 1 2 1 2 1 1 1 2 2 2 2 2 1|
Metaplasia, Osseous | 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 5| 2| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2|
DAY ON TEST | 2| 2| 2| 6| 5| 2| 1| 2| 7| 7| 2| 2| 9| 7| 7| 2| 2| 2| 1| 5| 2| 2| 2| 0| 7|
| 9| 9| 0| 1| 3| 9| 2| 1| 4| 4| 9| 9| 3| 4| 6| 9| 9| 9| 4| 0| 9| 9| 3| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Angiectasis | 1 2 1 2 1 1 1 1 |
Hyperplasia | 1 2 |
Vacuolization Cytoplasmic | 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 2 1 1 1 1 1 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 2 2 1|
Pars Distalis, Hyperplasia | 1 2 2 2 3 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 3 |
Inflammation, Chronic Active | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | 2 2 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 2 |
Inflammation, Chronic Active | 2 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Abscess | 2 |
Cyst | |
Hyperplasia | 2 2 |
Inflammation, Acute | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 2 2 1 2 2 2 1 1 2 2 2 2 2 1 2 1 2 3 2 1 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic Active | 1 2 1 1 2 3 3 2 1 2 2 2 |
Metaplasia, Squamous | |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 3 |
Autolysis | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 5| 2| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2|
DAY ON TEST | 2| 2| 2| 6| 5| 2| 1| 2| 7| 7| 2| 2| 9| 7| 7| 2| 2| 2| 1| 5| 2| 2| 2| 0| 7|
| 9| 9| 0| 1| 3| 9| 2| 1| 4| 4| 9| 9| 3| 4| 6| 9| 9| 9| 4| 0| 9| 9| 3| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1|
Seminiferous Tubule, Atrophy | 4 4 4 2 3 4 4 3 4 4 4 2 3 4 4 4 3 3 4 4 4 4 |
Seminiferous Tubule, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Autolysis | 2 |
__________________________________________________________________________|
Lymph Node | + M + + + +|
Lumbar, Pigmentation | |
Mediastinal, Hemorrhage | 2|
Pancreatic, Hemorrhage | 2 |
Pancreatic, Hyperplasia | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 1 1 |
Pancreatic, Inflammation, Chronic | |
Active | |
Renal, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 1 |
Hyperplasia | 1 2 2 3 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 |
Hyperplasia | |
Infiltration Cellular, Histiocyte | 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Fibrosis | 3 2 |
Hyperplasia, Re Cell | 2 |
__________________________________________________________________________|
Thymus | + + M + M M M + + + + + + M + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M M M + M + M M + + + M + M M M M M + + +|
Galactocele | 4 |
Hyperplasia | 1 2 2 1 2 1 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Cyst Epithelial Inclusion | 2 X 2 |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 5| 2| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2|
DAY ON TEST | 2| 2| 2| 6| 5| 2| 1| 2| 7| 7| 2| 2| 9| 7| 7| 2| 2| 2| 1| 5| 2| 2| 2| 0| 7|
| 9| 9| 0| 1| 3| 9| 2| 1| 4| 4| 9| 9| 3| 4| 6| 9| 9| 9| 4| 0| 9| 9| 3| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | |
Joint, Tarsal, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Skeletal Muscle | + |
Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 2 1 |
Alveolar Epithelium, Hyperplasia | 1 1 |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Bronchiole, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 1 |
Inflammation, Chronic Active | 3 1 1 1 2 1 3 4 3 4 |
Metaplasia, Squamous | 2 2 1 2 |
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Acanthosis | |
Hyperplasia, Basal Cell | |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Cyst | |
Infiltration Cellular, Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 5| 2| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 2|
DAY ON TEST | 2| 2| 2| 6| 5| 2| 1| 2| 7| 7| 2| 2| 9| 7| 7| 2| 2| 2| 1| 5| 2| 2| 2| 0| 7|
| 9| 9| 0| 1| 3| 9| 2| 1| 4| 4| 9| 9| 3| 4| 6| 9| 9| 9| 4| 0| 9| 9| 3| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cell | 1 1|
Nephropathy | 3 3 2 2 3 3 4 3 3 3 4 3 2 3 3 3 3 2 2 3 3 4 |
Collecting Tubule, Mineralization | |
Renal Tubule, Degeneration, Hyaline | 2 2 2|
Renal Tubule, Hyperplasia | 1 4 2 4 4 3 4 |
Renal Tubule, Inflammation, Chronic | |
Active | 1 1 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Mineralization | 1 1 1 1 1 |
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Renal Tubule, Regeneration | 1 2 2|
Transitional Epithelium, Hyperplasia | 2 2 1 1 2 1 3 1 1 2 3 2 2 3 3 1 1 2 3 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + M + + + + + + + + + + + +|
Autolysis | 4 |
Calculus Micro Observation Only | |
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | 2 2 1 1 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 109
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 2| 7| 7| 6| 6| 2| 6| 5| 4| 2| 2| 7| 6| 6| 5| 2| 6| 6| 6| 2| 2|
DAY ON TEST | 2| 2| 0| 6| 7| 2| 0| 7| 2| 7| 5| 8| 7| 7| 7| 3| 7| 3| 8| 7| 5| 3| 3| 7| 7|
| 9| 9| 0| 3| 6| 9| 2| 4| 9| 5| 0| 4| 8| 4| 4| 0| 4| 7| 2| 6| 9| 6| 6| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | |
Parasite Metazoan | 1 1 1 2 |
Polyarteritis | |
Ulcer | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 2 |
Inflammation, Chronic Active | 3 |
Parasite Metazoan | 1 |
Artery, Neovascularization | |
Artery, Thrombosis | |
Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 2 |
Autolysis | |
Hyperplasia, Lymphoid | |
Parasite Metazoan | 1 1 2 1 |
Lymphoid Tissue, Hemorrhage | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Ectopic Tissue | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 1 2 4 2 4 1|
Clear Cell Focus | 2 2 1 2 2 1 1 1 4 4 |
Cyst | |
Degeneration | 1 1 |
Eosinophilic Focus | 3 1 |
Fatty Change | 2 1 1 1 1 1 2 1 |
Hematopoietic Cell Proliferation | 2 1 |
Hemorrhage | 2 |
Infarct | 4 |
Inflammation, Chronic Active | 2 1 2 |
Mixed Cell Focus | |
Necrosis, Coagulative | 2 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 2 2 1 |
Bile Duct, Hyperplasia | 1 1 1 2 2 1 1 1 1 1 1 2 1 2 1 2 1 |
Periportal, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 110
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 2| 7| 7| 6| 6| 2| 6| 5| 4| 2| 2| 7| 6| 6| 5| 2| 6| 6| 6| 2| 2|
DAY ON TEST | 2| 2| 0| 6| 7| 2| 0| 7| 2| 7| 5| 8| 7| 7| 7| 3| 7| 3| 8| 7| 5| 3| 3| 7| 7|
| 9| 9| 0| 3| 6| 9| 2| 4| 9| 5| 0| 4| 8| 4| 4| 0| 4| 7| 2| 6| 9| 6| 6| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | + |
Fibrosis | |
Hemorrhage | |
Inflammation, Chronic Active | 3 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 1 1 1 |
Autolysis | |
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Inflammation, Chronic Active | 1 2 1 1 1 1 1 1 1 1 1 |
Vacuolization Cytoplasmic | 1 1 |
Acinus, Hyperplasia | |
Artery, Fibrosis | |
Artery, Polyarteritis | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + M + + + + + +|
Parotid Gland, Inflammation, Chronic | |
Submandibular Gland, Inflammation, | |
Chronic | |
Submandibular Gland, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Fibrosis | 3 |
Hyperkeratosis | 2 2 2 2 2 2 3 2 2 |
Hyperplasia, Basal Cell | 2 2 2 3 1 2 2 1 |
Hyperplasia, Squamous | 3 3 3 3 4 3 4 3 4 3 3 |
Infarct | |
Inflammation, Chronic Active | 3 3 2 |
Ulcer | 1 3 4 2 3 3 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 1 1 1 2 1 2 1 1 1 1 1 2 1 2 1 1 1 1|
Metaplasia, Osseous | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 111
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 2| 7| 7| 6| 6| 2| 6| 5| 4| 2| 2| 7| 6| 6| 5| 2| 6| 6| 6| 2| 2|
DAY ON TEST | 2| 2| 0| 6| 7| 2| 0| 7| 2| 7| 5| 8| 7| 7| 7| 3| 7| 3| 8| 7| 5| 3| 3| 7| 7|
| 9| 9| 0| 3| 6| 9| 2| 4| 9| 5| 0| 4| 8| 4| 4| 0| 4| 7| 2| 6| 9| 6| 6| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Angiectasis | 2 |
Hyperplasia | |
Vacuolization Cytoplasmic | 1 1 2 1 1 2 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + |
Autolysis | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M M + + + + + + M + + + + + + + +|
Pars Distalis, Cyst | 2 2 |
Pars Distalis, Hyperplasia | 1 1 2 2 2 1 1 1 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 1 |
Ultimobranchial Cyst | 1 1 1 |
C-Cell, Hyperplasia | 1 1 1 1 |
Follicle, Cyst | 1 2 2 |
Follicular Cell, Hyperplasia | 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + M + + + + + + + M + + + + + + + + + +|
Abscess | |
Cyst | |
Hyperplasia | |
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 2 1 2 1 2 2 2 1 2 2 2 1 2|
__________________________________________________________________________|
Prostate | + + + + M + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Inflammation, Chronic Active | 3 2 2 2 |
Metaplasia, Squamous | 4 2 2 |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 2 3 2 2 2 |
Autolysis | |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
_____________________________________________________________________________________________________________________|
Page 112
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 2| 7| 7| 6| 6| 2| 6| 5| 4| 2| 2| 7| 6| 6| 5| 2| 6| 6| 6| 2| 2|
DAY ON TEST | 2| 2| 0| 6| 7| 2| 0| 7| 2| 7| 5| 8| 7| 7| 7| 3| 7| 3| 8| 7| 5| 3| 3| 7| 7|
| 9| 9| 0| 3| 6| 9| 2| 4| 9| 5| 0| 4| 8| 4| 4| 0| 4| 7| 2| 6| 9| 6| 6| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | |
Interstitial Cell, Hyperplasia | 1 2 1 1 1 2 1 1 1 1 1 1 |
Seminiferous Tubule, Atrophy | 4 4 2 4 4 4 3 4 4 4 3 4 4 4 3 3 |
Seminiferous Tubule, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Autolysis | |
__________________________________________________________________________|
Lymph Node | + M + + M + + + + + M|
Lumbar, Pigmentation | 1 |
Mediastinal, Hemorrhage | 1 1 1 |
Pancreatic, Hemorrhage | |
Pancreatic, Hyperplasia | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 3 2 |
Pancreatic, Inflammation, Chronic | |
Active | 2 |
Renal, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + M + + M + + + + + +|
Hemorrhage | 3 1 1 3 2|
Hyperplasia | 2 2 3 |
Infiltration Cellular, Histiocyte | 1 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 2 1 1|
Pigmentation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Fibrosis | |
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + M M M + + + + + M + + + + + +|
Depletion Lymphoid | 4 3 1 2|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + M + + M + + + M + M M M + M + + M + + M + M|
Galactocele | |
Hyperplasia | 1 1 2 1 1 2 1 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + I + + + + + + + + + + + +|
Abscess | |
Cyst Epithelial Inclusion | |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 113
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 2| 7| 7| 6| 6| 2| 6| 5| 4| 2| 2| 7| 6| 6| 5| 2| 6| 6| 6| 2| 2|
DAY ON TEST | 2| 2| 0| 6| 7| 2| 0| 7| 2| 7| 5| 8| 7| 7| 7| 3| 7| 3| 8| 7| 5| 3| 3| 7| 7|
| 9| 9| 0| 3| 6| 9| 2| 4| 9| 5| 0| 4| 8| 4| 4| 0| 4| 7| 2| 6| 9| 6| 6| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | 3 |
Joint, Tarsal, Inflammation, Chronic | |
Active | 4 |
__________________________________________________________________________|
Skeletal Muscle | |
Fibrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Infiltration Cellular, Histiocyte | 1 1 3 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 2 |
Alveolar Epithelium, Hyperplasia | 3 |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Bronchiole, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 1 |
Inflammation, Chronic Active | 1 1 3 1 1 3 2 1 1 1 |
Metaplasia, Squamous | 1 2 |
Respiratory Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Acanthosis | |
Hyperplasia, Basal Cell | |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Cyst | |
Infiltration Cellular, Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 114
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 2| 7| 7| 6| 6| 2| 6| 5| 4| 2| 2| 7| 6| 6| 5| 2| 6| 6| 6| 2| 2|
DAY ON TEST | 2| 2| 0| 6| 7| 2| 0| 7| 2| 7| 5| 8| 7| 7| 7| 3| 7| 3| 8| 7| 5| 3| 3| 7| 7|
| 9| 9| 0| 3| 6| 9| 2| 4| 9| 5| 0| 4| 8| 4| 4| 0| 4| 7| 2| 6| 9| 6| 6| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5% | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cell | 1 1 1 1 1 1 1|
Nephropathy | 3 3 3 3 3 4 3 3 4 3 3 3 3 2 2 3 3 2 |
Collecting Tubule, Mineralization | 1 |
Renal Tubule, Degeneration, Hyaline | 2 2 2 2 2 2 2|
Renal Tubule, Hyperplasia | 2 3 4 2 4 3 2 1 2 2 |
Renal Tubule, Inflammation, Chronic | |
Active | 1 1 1 1 1 1 |
Renal Tubule, Mineralization | 2 1 1 1 1 |
Renal Tubule, Pigmentation | 2 2 2 2 1 2 2 2 2 1 2 2 2 1 1 1 2 2 2 2 2 2 2 2 1|
Renal Tubule, Regeneration | 1 2 1 1 2 1 2|
Transitional Epithelium, Hyperplasia | 2 2 2 3 2 2 1 3 1 1 3 2 2 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Calculus Micro Observation Only | 2 |
Inflammation, Chronic | 1 |
Transitional Epithelium, Hyperplasia | 3 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 115
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6| | |
DAY ON TEST | 3| 8| 2| 2| 6| 3| 3| 2| 1| 0| 3| 3| 0| 9| 0| 3| 3| 8| 5| 0| | |
| 0| 5| 9| 1| 5| 0| 0| 8| 5| 9| 0| 0| 0| 8| 8| 0| 0| 7| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + | 69 |
Autolysis | 1 | 4 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Parasite Metazoan | 1 1 1 | 12 1.1|
Polyarteritis | | 1 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + | 68 |
Atypia Cellular | 2 | 2 2.0|
Inflammation, Chronic Active | | 1 3.0|
Parasite Metazoan | 2 1 1 1 | 9 1.2|
Artery, Neovascularization | 2 | 2 2.0|
Artery, Thrombosis | | 1 2.0|
Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + | 69 |
Atypia Cellular | | 1 2.0|
Autolysis | 2 | 3 2.3|
Hyperplasia, Lymphoid | | 1 2.0|
Parasite Metazoan | 1 1 1 | 11 1.1|
Lymphoid Tissue, Hemorrhage | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + | 69 |
Autolysis | | 3 2.0|
Ectopic Tissue | | 1 3.0|
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + M + + + + + + + + + + + + | 67 |
Autolysis | 2 | 5 2.4|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + | 67 |
Autolysis | 3 | 4 2.3|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + | 69 |
Basophilic Focus | 1 1 1 1 1 1 2 2 1 2 | 25 1.8|
Clear Cell Focus | 1 2 1 1 1 3 1 3 2 2 2 2 2 2 | 39 1.8|
Cyst | 2 | 1 2.0|
Degeneration | 1 1 1 1 2 1 | 12 1.1|
Eosinophilic Focus | 3 1 2 2 1 | 14 2.1|
Fatty Change | 1 | 13 1.2|
Hematopoietic Cell Proliferation | 1 1 | 4 1.3|
Hemorrhage | | 1 2.0|
Infarct | | 1 4.0|
Inflammation, Chronic Active | 1 | 4 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 116
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6| | |
DAY ON TEST | 3| 8| 2| 2| 6| 3| 3| 2| 1| 0| 3| 3| 0| 9| 0| 3| 3| 8| 5| 0| | |
| 0| 5| 9| 1| 5| 0| 0| 8| 5| 9| 0| 0| 0| 8| 8| 0| 0| 7| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mixed Cell Focus | 1 2 2 2 2 | 8 2.0|
Necrosis, Coagulative | 2 1 3 | 8 2.0|
Pigmentation | 1 1 2 2 1 1 1 2 1 1 1 1 1 2 1 1 1 | 48 1.1|
Bile Duct, Hyperplasia | 2 1 1 1 1 2 1 1 2 1 2 1 1 2 1 1 1 | 54 1.2|
Periportal, Inflammation, Chronic | | |
Active | 2 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 | 61 1.1|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fibrosis | | 2 3.0|
Hemorrhage | 2 | 1 2.0|
Inflammation, Chronic Active | | 3 2.3|
Necrosis, Coagulative | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + | 69 |
Atrophy | 2 1 2 3 2 1 1 1 2 2 1 1 1 | 29 1.4|
Autolysis | 1 | 2 1.5|
Infiltration Cellular, Mononuclear | | |
Cell | | 2 1.0|
Inflammation, Chronic Active | 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1 | 45 1.1|
Vacuolization Cytoplasmic | 1 | 6 1.3|
Acinus, Hyperplasia | 2 | 1 2.0|
Artery, Fibrosis | | 1 4.0|
Artery, Polyarteritis | | 4 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + | 68 |
Parotid Gland, Inflammation, Chronic | | 1 1.0|
Submandibular Gland, Inflammation, | | |
Chronic | | 2 1.0|
Submandibular Gland, Metaplasia, | | |
Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + | 69 |
Erosion | | 1 2.0|
Fibrosis | | 1 3.0|
Hyperkeratosis | 2 2 1 2 2 2 | 21 2.0|
Hyperplasia, Basal Cell | 2 1 2 1 2 2 2 | 23 1.7|
Hyperplasia, Squamous | 2 3 3 3 3 4 3 | 25 3.2|
Infarct | | 1 4.0|
Inflammation, Chronic Active | 1 2 2 1 2 | 11 2.0|
Ulcer | 2 3 | 15 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + | 69 |
Autolysis | 1 | 2 1.5|
Inflammation, Chronic Active | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 117
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6| | |
DAY ON TEST | 3| 8| 2| 2| 6| 3| 3| 2| 1| 0| 3| 3| 0| 9| 0| 3| 3| 8| 5| 0| | |
| 0| 5| 9| 1| 5| 0| 0| 8| 5| 9| 0| 0| 0| 8| 8| 0| 0| 7| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + | 69 |
Cardiomyopathy | 1 1 2 2 1 1 1 2 2 1 2 2 2 1 1 2 1 2 2 | 65 1.5|
Metaplasia, Osseous | | 1 2.0|
Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + M + + + + + + + + + + + + | 68 |
Angiectasis | 2 2 1 2 | 13 1.5|
Hyperplasia | | 2 1.5|
Vacuolization Cytoplasmic | 1 1 1 1 | 19 1.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + M + + + + + + + + + + + + | 68 |
Hyperplasia | 2 1 2 1 1 1 1 | 24 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + | 58 |
Autolysis | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + | 65 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + | 65 |
Pars Distalis, Cyst | 1 1 | 8 1.5|
Pars Distalis, Hyperplasia | 1 1 1 1 3 1 | 24 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + | 69 |
Autolysis | | 2 2.5|
Inflammation, Chronic Active | | 1 1.0|
Ultimobranchial Cyst | 1 | 4 1.0|
C-Cell, Hyperplasia | | 5 1.0|
Follicle, Cyst | 1 | 7 1.7|
Follicular Cell, Hyperplasia | | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + | 69 |
Autolysis | | 2 2.0|
Inflammation, Chronic Active | 1 | 10 1.2|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + | 66 |
Abscess | | 1 2.0|
Cyst | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 118
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6| | |
DAY ON TEST | 3| 8| 2| 2| 6| 3| 3| 2| 1| 0| 3| 3| 0| 9| 0| 3| 3| 8| 5| 0| | |
| 0| 5| 9| 1| 5| 0| 0| 8| 5| 9| 0| 0| 0| 8| 8| 0| 0| 7| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | | 2 2.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 1 2 2 2 1 2 1 1 2 2 2 2 2 2 1 2 2 1 2 | 59 1.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + | 68 |
Abscess | | 1 4.0|
Inflammation, Chronic Active | 2 2 2 2 2 1 2 2 4 | 25 2.0|
Metaplasia, Squamous | 2 2 2 | 6 2.3|
Epithelium, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + | 69 |
Atrophy | 3 2 2 4 2 3 3 3 3 3 3 | 36 2.7|
Autolysis | | 1 3.0|
Inflammation, Chronic Active | 2 | 2 1.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + | 69 |
Atrophy | | 1 1.0|
Inflammation, Chronic | 2 | 1 2.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 2 1 1 1 1 | 32 1.1|
Seminiferous Tubule, Atrophy | 4 4 3 3 4 4 4 3 4 4 4 3 3 4 4 4 3 | 55 3.6|
Seminiferous Tubule, Mineralization | | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + | 69 |
Sternal, Autolysis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 18 |
Lumbar, Pigmentation | | 1 1.0|
Mediastinal, Hemorrhage | | 4 1.3|
Pancreatic, Hemorrhage | | 1 2.0|
Pancreatic, Hyperplasia | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 2 2 2 1 | 10 1.8|
Pancreatic, Inflammation, Chronic | | |
Active | | 1 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + M + + + + + + + + + | 64 |
Hemorrhage | | 7 2.0|
Hyperplasia | | 7 2.1|
Infiltration Cellular, Histiocyte | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + | 67 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 119
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6| | |
DAY ON TEST | 3| 8| 2| 2| 6| 3| 3| 2| 1| 0| 3| 3| 0| 9| 0| 3| 3| 8| 5| 0| | |
| 0| 5| 9| 1| 5| 0| 0| 8| 5| 9| 0| 0| 0| 8| 8| 0| 0| 7| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Autolysis | | 1 1.0|
Hyperplasia | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 66 1.1|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + M + + + + + + + + + + + | 68 |
Autolysis | | 1 2.0|
Fibrosis | | 2 2.5|
Hyperplasia, Re Cell | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + M + M + + M M + M + M M | 51 |
Depletion Lymphoid | | 5 2.4|
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M + M + + + M M M + M + + + M M + | 34 |
Galactocele | | 1 4.0|
Hyperplasia | 1 2 2 1 2 1 | 22 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + | 68 |
Abscess | | 1 4.0|
Cyst Epithelial Inclusion | | 3 2.0|
Inflammation, Chronic Active | | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + | 69 |
Joint, Tarsal, Hyperostosis | | 1 3.0|
Joint, Tarsal, Inflammation, Chronic | | |
Active | | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + | 69 |
Fibrosis | 1 2 | 3 1.3|
Infiltration Cellular, Histiocyte | 1 2 1 1 1 1 1 2 1 | 34 1.1|
Inflammation, Chronic Active | | 5 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 120
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6| | |
DAY ON TEST | 3| 8| 2| 2| 6| 3| 3| 2| 1| 0| 3| 3| 0| 9| 0| 3| 3| 8| 5| 0| | |
| 0| 5| 9| 1| 5| 0| 0| 8| 5| 9| 0| 0| 0| 8| 8| 0| 0| 7| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 | 7 1.3|
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 | 41 1.0|
Bronchiole, Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + | 69 |
Foreign Body | 1 1 2 | 7 1.6|
Inflammation, Chronic Active | 2 1 1 1 2 1 4 | 27 1.9|
Metaplasia, Squamous | 4 | 7 2.0|
Respiratory Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + | 69 |
Inflammation, Chronic Active | | 3 1.3|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
Acanthosis | 2 | 1 2.0|
Hyperplasia, Basal Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 4.0|
Retina, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + | 69 |
Autolysis | | 1 3.0|
Cyst | 2 | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell | | 9 1.0|
Nephropathy | 3 3 3 2 2 3 3 3 3 4 3 3 3 3 2 3 3 3 3 | 59 2.9|
Collecting Tubule, Mineralization | | 1 1.0|
Renal Tubule, Degeneration, Hyaline | 3 | 11 2.1|
Renal Tubule, Hyperplasia | 3 2 1 4 1 1 1 1 | 25 2.4|
Renal Tubule, Inflammation, Chronic | | |
Active | 1 1 1 1 1 | 22 1.0|
Renal Tubule, Mineralization | 2 1 1 | 13 1.2|
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 68 1.9|
Renal Tubule, Regeneration | | 10 1.5|
Transitional Epithelium, Hyperplasia | 2 2 1 2 1 2 1 4 2 2 2 1 2 2 2 | 51 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + | 67 |
Autolysis | | 1 4.0|
Calculus Micro Observation Only | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 121
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 6| 6| | |
DAY ON TEST | 3| 8| 2| 2| 6| 3| 3| 2| 1| 0| 3| 3| 0| 9| 0| 3| 3| 8| 5| 0| | |
| 0| 5| 9| 1| 5| 0| 0| 8| 5| 9| 0| 0| 0| 8| 8| 0| 0| 7| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5% | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
71MLM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 1.0|
Transitional Epithelium, Hyperplasia | 3 1 1 4 1 2 | 17 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 122
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 5| 4| 5| 4| 7| 4| 4| 6| 2| 4| 7| 7| 6| 2| 7| 6| 5| 2| 2| 6| 4| 5| 4| 2|
DAY ON TEST | 0| 9| 5| 5| 9| 2| 5| 5| 7| 7| 5| 2| 2| 2| 7| 2| 1| 8| 7| 7| 3| 5| 9| 7| 7|
| 9| 6| 8| 3| 3| 9| 6| 8| 9| 4| 6| 9| 9| 4| 4| 1| 0| 1| 6| 6| 1| 8| 0| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 3 3 |
Parasite Metazoan | 1 1 X 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 3 3 |
Parasite Metazoan | 1 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 3 3 |
Inflammation, Chronic Active | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 4 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + A + +|
Autolysis | 2 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + +|
Autolysis | 4 2 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Basophilic Focus | 1 2 2 1 1 1 1 1|
Clear Cell Focus | 1 1 2 1 1 1 1 3 1 3 1 1|
Cyst | |
Cytomegaly | 1 |
Degeneration | 1 1 |
Developmental Malformation | |
Eosinophilic Focus | 3 1 |
Fatty Change | 2 1 1 1 1 |
Hemorrhage | |
Hyperplasia | |
Inflammation, Chronic, Granulomatous | 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Mixed Cell Focus | 1 |
Necrosis, Coagulative | 2 3 |
Pigmentation | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Bile Duct, Hyperplasia | 1 2 1 1 1 2 1 1 2 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1|
Periportal, Inflammation, Chronic | 2 1 2 2 2 |
Periportal, Inflammation, Chronic | |
Active | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
Periportal, Inflammation | 1 |
__________________________________________________________________________|
Mesentery | + M + M M M M|
Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 123
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 5| 4| 5| 4| 7| 4| 4| 6| 2| 4| 7| 7| 6| 2| 7| 6| 5| 2| 2| 6| 4| 5| 4| 2|
DAY ON TEST | 0| 9| 5| 5| 9| 2| 5| 5| 7| 7| 5| 2| 2| 2| 7| 2| 1| 8| 7| 7| 3| 5| 9| 7| 7|
| 9| 6| 8| 3| 3| 9| 6| 8| 9| 4| 6| 9| 9| 4| 4| 1| 0| 1| 6| 6| 1| 8| 0| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hemorrhage | |
Inflammation, Chronic Active | 2 |
Necrosis, Coagulative | 2 |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 1 3 1 3 |
Autolysis | 2 |
Cytoplasmic Alteration | |
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 3 |
Vacuolization Cytoplasmic | 1 1 1 1 1 |
Acinus, Hyperplasia | |
Artery, Fibrosis | 4 |
Artery, Polyarteritis | 4 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Pharynx | |
Palate, Hyperkeratosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Duct, Submandibular Gland, | |
Inflammation, Acute | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Fibrosis | 2 |
Hyperkeratosis | 2 3 2 2 |
Hyperplasia, Basal Cell | 2 2 2 1 2 |
Hyperplasia, Squamous | 3 2 3 3 3 4 2 |
Inflammation, Chronic Active | 2 3 2 1 |
Ulcer | 3 3 3 |
Arteriole, Mineralization | |
Muscularis, Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Inflammation, Chronic Active | 2 |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 1 1 3 1 1 2 2 1 1 2 1 2 1 1 2 2 2|
Infiltration Cellular, Mononuclear | |
Cell | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 124
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 5| 4| 5| 4| 7| 4| 4| 6| 2| 4| 7| 7| 6| 2| 7| 6| 5| 2| 2| 6| 4| 5| 4| 2|
DAY ON TEST | 0| 9| 5| 5| 9| 2| 5| 5| 7| 7| 5| 2| 2| 2| 7| 2| 1| 8| 7| 7| 3| 5| 9| 7| 7|
| 9| 6| 8| 3| 3| 9| 6| 8| 9| 4| 6| 9| 9| 4| 4| 1| 0| 1| 6| 6| 1| 8| 0| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 1 1 |
Autolysis | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | |
Vacuolization Cytoplasmic | 1 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Hyperplasia | 1 1 1 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + |
Autolysis | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + M M + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + +|
Autolysis | |
Cyst | 1|
Pars Distalis, Cyst | 1 1 1|
Pars Distalis, Hyperplasia | 2 1 2 1 2 2 1 2 2 2 1 |
Pars Intermedia, Cyst | 1 |
Pars Nervosa, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + M + + + + + + + + +|
Cyst | 2 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 2 1 2 2 1 1 1 2 2 3 3 1 1 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + M +|
Abscess | 4 |
Fibrosis | 2 |
Inflammation, Chronic Active | 4 2 4 1 2 |
Metaplasia, Squamous | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 125
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 5| 4| 5| 4| 7| 4| 4| 6| 2| 4| 7| 7| 6| 2| 7| 6| 5| 2| 2| 6| 4| 5| 4| 2|
DAY ON TEST | 0| 9| 5| 5| 9| 2| 5| 5| 7| 7| 5| 2| 2| 2| 7| 2| 1| 8| 7| 7| 3| 5| 9| 7| 7|
| 9| 6| 8| 3| 3| 9| 6| 8| 9| 4| 6| 9| 9| 4| 4| 1| 0| 1| 6| 6| 1| 8| 0| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 2 |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Chronic | 3 |
Atrophy | 4 |
Infarct, Chronic | 4 |
Infarct | 4 |
Interstitial Cell, Hyperplasia | 1 1 2 1 2 2 1 1 1 1 1 1 1 1 1|
Seminiferous Tubule, Atrophy | 3 2 1 1 4 4 4 4 4 3 4 4 4 3 |
Seminiferous Tubule, Mineralization | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Sternal, Hypoplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + M + + M M + + M|
Deep Cervical, Hyperplasia | 2 |
Lumbar, Hyperplasia | 1 |
Mediastinal, Hemorrhage | 1 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 1 |
Mediastinal, Pigmentation | 2 1 |
Pancreatic, Hyperplasia | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 2 3 2 2 2 2 2 2 |
Pancreatic, Pigmentation | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 3 1 |
Hyperplasia | 2 2 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | |
Infiltration Cellular, Histiocyte | 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1|
Pigmentation | 1 1 1 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Depletion Lymphoid | 3 3 |
Fibrosis | 3 |
Infiltration Cellular, Histiocyte | 1 |
Pigmentation | 2 1 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + M + + + + + + + + +|
Depletion Lymphoid | 2 1 1 2 3 2|
Hemorrhage | 2 2 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 126
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 5| 4| 5| 4| 7| 4| 4| 6| 2| 4| 7| 7| 6| 2| 7| 6| 5| 2| 2| 6| 4| 5| 4| 2|
DAY ON TEST | 0| 9| 5| 5| 9| 2| 5| 5| 7| 7| 5| 2| 2| 2| 7| 2| 1| 8| 7| 7| 3| 5| 9| 7| 7|
| 9| 6| 8| 3| 3| 9| 6| 8| 9| 4| 6| 9| 9| 4| 4| 1| 0| 1| 6| 6| 1| 8| 0| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M + M + M M M M M + M + + + + M M M M +|
Hyperplasia | 1 2 2 1 2 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Cranium, Abscess | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 2 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Hemorrhage | 2 2 |
Inflammation, Chronic Active | 3 3 4 2 3 |
Metaplasia, Squamous | 2 1 2 |
Glands, Hyperplasia | 2 2 |
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Submucosa, Abscess | 2 |
__________________________________________________________________________|
Eye | M + |
Synechia | |
Lens, Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 127
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 5| 4| 5| 4| 7| 4| 4| 6| 2| 4| 7| 7| 6| 2| 7| 6| 5| 2| 2| 6| 4| 5| 4| 2|
DAY ON TEST | 0| 9| 5| 5| 9| 2| 5| 5| 7| 7| 5| 2| 2| 2| 7| 2| 1| 8| 7| 7| 3| 5| 9| 7| 7|
| 9| 6| 8| 3| 3| 9| 6| 8| 9| 4| 6| 9| 9| 4| 4| 1| 0| 1| 6| 6| 1| 8| 0| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 3 |
Infiltration Cellular, Mononuclear | |
Cell | 1 2 1 1|
Nephropathy | 3 2 2 2 2 3 3 2 3 2 3 3 3 3 3 2 2 3 3 2 |
Renal Tubule, Degeneration, Hyaline | 1 2 2 2 2|
Renal Tubule, Hyperplasia | 3 2 4 3 |
Renal Tubule, Hyperplasia, Oncocytic | |
Renal Tubule, Inflammation, Chronic | |
Active | 1 1 1 1 |
Renal Tubule, Mineralization | |
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2|
Renal Tubule, Regeneration | 2 2 2 2|
Transitional Epithelium, Hyperplasia | 2 1 2 2 1 1 2 2 2 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 1 |
Metaplasia, Squamous | 2 |
Transitional Epithelium, Hyperplasia | 1 2 2 2 2 2 2 2 |
Transitional Epithelium, Metaplasia, | |
Squamous | |
_____________________________________________________________________________________________________________________|
Page 128
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 2| 4| 7| 5| 5| 5| 7| 5| 2| 2| 2| 7| 4| 7| 6| 4| 7| 5| 5| 4| 2|
DAY ON TEST | 2| 2| 2| 3| 8| 5| 1| 9| 7| 2| 2| 8| 7| 7| 7| 2| 5| 1| 8| 9| 2| 7| 4| 5| 7|
| 9| 9| 2| 5| 1| 8| 4| 1| 7| 7| 9| 8| 5| 4| 5| 4| 6| 5| 9| 7| 4| 3| 2| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | M + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +|
Autolysis | 4 |
Parasite Metazoan | 1 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Inflammation, Chronic Active | |
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 3 4 3 |
Hyperplasia, Lymphoid | 2 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Basophilic Focus | 2 2 1 1 1 1 1 |
Clear Cell Focus | 3 2 4 2 1 1 2 1 1 2 1 1 1 |
Cyst | X 2 |
Cytomegaly | |
Degeneration | 1 |
Developmental Malformation | X|
Eosinophilic Focus | 3 3 3 |
Fatty Change | 1 1 1 1 |
Hemorrhage | 2 |
Hyperplasia | 3 |
Inflammation, Chronic, Granulomatous | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 2 1|
Mixed Cell Focus | |
Necrosis, Coagulative | 2 1 1|
Pigmentation | 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1|
Bile Duct, Hyperplasia | 1 2 1 1 2 2 2 2 2 1 2 2 3 2 1 1 1 |
Periportal, Inflammation, Chronic | 2 2 2 |
Periportal, Inflammation, Chronic | |
Active | 1 1 1 2 1 1 1 1 2 1 1 1 |
Periportal, Inflammation | |
__________________________________________________________________________|
Mesentery | M M + + M|
Fibrosis | |
_____________________________________________________________________________________________________________________|
Page 129
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 2| 4| 7| 5| 5| 5| 7| 5| 2| 2| 2| 7| 4| 7| 6| 4| 7| 5| 5| 4| 2|
DAY ON TEST | 2| 2| 2| 3| 8| 5| 1| 9| 7| 2| 2| 8| 7| 7| 7| 2| 5| 1| 8| 9| 2| 7| 4| 5| 7|
| 9| 9| 2| 5| 1| 8| 4| 1| 7| 7| 9| 8| 5| 4| 5| 4| 6| 5| 9| 7| 4| 3| 2| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Hemorrhage | 3 4 |
Inflammation, Chronic Active | 3 4 |
Necrosis, Coagulative | |
Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 2 1 1 |
Autolysis | 2 |
Cytoplasmic Alteration | 1 |
Infiltration Cellular, Mononuclear | |
Cell | 1 2 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 |
Vacuolization Cytoplasmic | 1 2 1 1 1 |
Acinus, Hyperplasia | |
Artery, Fibrosis | |
Artery, Polyarteritis | 2 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Pharynx | |
Palate, Hyperkeratosis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Duct, Submandibular Gland, | |
Inflammation, Acute | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Fibrosis | |
Hyperkeratosis | 2 2 2 2 2 2 2 2 2 2 2 |
Hyperplasia, Basal Cell | 2 2 3 2 4 3 2 2 1 2 2 2 |
Hyperplasia, Squamous | 4 4 3 3 3 4 3 3 3 3 4 3 |
Inflammation, Chronic Active | 2 2 2 3 4 1 |
Ulcer | 3 3 2 4 2 3 4 2 |
Arteriole, Mineralization | 1 |
Muscularis, Mineralization | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic Active | 1 2 |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + M + +|
Cardiomyopathy | 2 1 2 1 1 1 1 1 2 1 1 2 2 2 1 1 1 |
Infiltration Cellular, Mononuclear | |
Cell | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 130
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 2| 4| 7| 5| 5| 5| 7| 5| 2| 2| 2| 7| 4| 7| 6| 4| 7| 5| 5| 4| 2|
DAY ON TEST | 2| 2| 2| 3| 8| 5| 1| 9| 7| 2| 2| 8| 7| 7| 7| 2| 5| 1| 8| 9| 2| 7| 4| 5| 7|
| 9| 9| 2| 5| 1| 8| 4| 1| 7| 7| 9| 8| 5| 4| 5| 4| 6| 5| 9| 7| 4| 3| 2| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 1 |
Autolysis | 3 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | |
Vacuolization Cytoplasmic | 1 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hyperplasia | 1 1 2 1 2 1 1 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + |
Autolysis | |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + M + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Cyst | |
Pars Distalis, Cyst | 1 2 2 2 |
Pars Distalis, Hyperplasia | 1 1 2 1 2 1 1 1 1 1 1 2 2 |
Pars Intermedia, Cyst | 1 |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Preputial Gland | M + + + + + + + + + + + + + + + M + + + + +|
Cyst | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 2 1 2 1 1 1 1 2 1 2 1 2 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Fibrosis | |
Inflammation, Chronic Active | 1 1 2 2 1 4 1 2 1 3 3 |
Metaplasia, Squamous | 3 |
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 131
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 2| 4| 7| 5| 5| 5| 7| 5| 2| 2| 2| 7| 4| 7| 6| 4| 7| 5| 5| 4| 2|
DAY ON TEST | 2| 2| 2| 3| 8| 5| 1| 9| 7| 2| 2| 8| 7| 7| 7| 2| 5| 1| 8| 9| 2| 7| 4| 5| 7|
| 9| 9| 2| 5| 1| 8| 4| 1| 7| 7| 9| 8| 5| 4| 5| 4| 6| 5| 9| 7| 4| 3| 2| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 2 3 3 3 2 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Chronic | |
Atrophy | |
Infarct, Chronic | |
Infarct | |
Interstitial Cell, Hyperplasia | 1 1 2 1 1 1 1 2 1 2 1 |
Seminiferous Tubule, Atrophy | 4 4 3 4 3 3 4 4 4 4 4 4 |
Seminiferous Tubule, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Hypoplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + M M M + + +|
Deep Cervical, Hyperplasia | |
Lumbar, Hyperplasia | |
Mediastinal, Hemorrhage | 2|
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Pigmentation | 1|
Pancreatic, Hyperplasia | 2 3 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 2 3 4 2 2 2 2|
Pancreatic, Pigmentation | 1|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1|
Hyperplasia | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Infiltration Cellular, Histiocyte | 1 2 1 1 1 1 2 1 1 2 2 1 1 1 1 1 1 2 1 3 2 2|
Pigmentation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Depletion Lymphoid | |
Fibrosis | 1 4 |
Infiltration Cellular, Histiocyte | |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + M M M + + M + + + M + + + + M + M M M M + + +|
Depletion Lymphoid | 2 2 2 2 |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 132
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 2| 4| 7| 5| 5| 5| 7| 5| 2| 2| 2| 7| 4| 7| 6| 4| 7| 5| 5| 4| 2|
DAY ON TEST | 2| 2| 2| 3| 8| 5| 1| 9| 7| 2| 2| 8| 7| 7| 7| 2| 5| 1| 8| 9| 2| 7| 4| 5| 7|
| 9| 9| 2| 5| 1| 8| 4| 1| 7| 7| 9| 8| 5| 4| 5| 4| 6| 5| 9| 7| 4| 3| 2| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M + + + M + + M + M M M + M + + +|
Hyperplasia | 1 2 1 1 1 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Abscess | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + M + +|
Foreign Body | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage | 3 |
Inflammation, Chronic Active | 1 2 2 1 1 |
Metaplasia, Squamous | 2 |
Glands, Hyperplasia | |
Respiratory Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Submucosa, Abscess | |
__________________________________________________________________________|
Eye | + |
Synechia | |
Lens, Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 133
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 2| 4| 7| 5| 5| 5| 7| 5| 2| 2| 2| 7| 4| 7| 6| 4| 7| 5| 5| 4| 2|
DAY ON TEST | 2| 2| 2| 3| 8| 5| 1| 9| 7| 2| 2| 8| 7| 7| 7| 2| 5| 1| 8| 9| 2| 7| 4| 5| 7|
| 9| 9| 2| 5| 1| 8| 4| 1| 7| 7| 9| 8| 5| 4| 5| 4| 6| 5| 9| 7| 4| 3| 2| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.0% | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1|
Nephropathy | 3 3 3 1 1 2 4 2 3 2 3 3 4 3 3 3 2 4 3 3 3 |
Renal Tubule, Degeneration, Hyaline | 3 2 2 2 2|
Renal Tubule, Hyperplasia | 4 4 3 2 1 4 3 3 4 2 1 |
Renal Tubule, Hyperplasia, Oncocytic | |
Renal Tubule, Inflammation, Chronic | |
Active | 1 1 1 1 |
Renal Tubule, Mineralization | 1 1 1 |
Renal Tubule, Pigmentation | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Renal Tubule, Regeneration | 2 2 1 1|
Transitional Epithelium, Hyperplasia | 1 1 1 2 2 1 3 2 2 1 2 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic Active | 1 2 |
Metaplasia, Squamous | |
Transitional Epithelium, Hyperplasia | 2 3 1 1 1 2 2 1 2 3 |
Transitional Epithelium, Metaplasia, | |
Squamous | 2 |
_____________________________________________________________________________________________________________________|
Page 134
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 3| 6| 5| 4| 3| 2| 7| 7| 7| 6| 6| 7| 6| 6| 6| 4| | |
DAY ON TEST | 2| 0| 2| 3| 5| 4| 5| 5| 6| 7| 2| 2| 0| 7| 0| 2| 7| 7| 3| 5| | |
| 9| 3| 5| 6| 2| 6| 2| 6| 4| 5| 9| 9| 2| 4| 5| 9| 4| 1| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + | 61 |
Autolysis | 3 | 5 3.2|
Parasite Metazoan | 1 | 7 1.2|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 69 |
Autolysis | 3 | 5 3.0|
Parasite Metazoan | | 2 1.0|
Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + | 60 |
Autolysis | 3 | 5 3.4|
Inflammation, Chronic Active | 3 | 1 3.0|
Parasite Metazoan | 1 | 3 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + | 60 |
Autolysis | 4 | 5 3.6|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + | 58 |
Autolysis | 4 3 | 6 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + | 59 |
Autolysis | 4 2 | 9 3.0|
Hyperplasia, Lymphoid | | 2 1.5|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | 3 | 2 2.5|
Basophilic Focus | 1 2 1 1 2 2 1 2 3 1 1 1 1 | 28 1.4|
Clear Cell Focus | 1 1 2 4 1 1 1 2 2 1 1 2 2 | 38 1.6|
Cyst | | 2 2.0|
Cytomegaly | | 1 1.0|
Degeneration | 1 | 4 1.0|
Developmental Malformation | | 1 |
Eosinophilic Focus | 1 X | 7 2.3|
Fatty Change | 1 1 | 11 1.1|
Hemorrhage | | 1 2.0|
Hyperplasia | | 1 3.0|
Inflammation, Chronic, Granulomatous | | 1 1.0|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 | 7 1.1|
Mixed Cell Focus | 3 | 2 2.0|
Necrosis, Coagulative | 1 3 1 1 2 | 10 1.7|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 55 1.1|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 2 2 1 1 2 2 2 1 1 | 60 1.4|
Periportal, Inflammation, Chronic | 2 2 | 10 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 135
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 3| 6| 5| 4| 3| 2| 7| 7| 7| 6| 6| 7| 6| 6| 6| 4| | |
DAY ON TEST | 2| 0| 2| 3| 5| 4| 5| 5| 6| 7| 2| 2| 0| 7| 0| 2| 7| 7| 3| 5| | |
| 9| 3| 5| 6| 2| 6| 2| 6| 4| 5| 9| 9| 2| 4| 5| 9| 4| 1| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Periportal, Inflammation, Chronic | | |
Active | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 | 44 1.1|
Periportal, Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | M + | 5 |
Fibrosis | 2 | 2 2.0|
Hemorrhage | | 2 3.5|
Inflammation, Chronic Active | 2 | 4 2.8|
Necrosis, Coagulative | | 1 2.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + | 60 |
Atrophy | 2 1 1 1 1 2 1 1 1 | 21 1.6|
Autolysis | | 2 2.0|
Cytoplasmic Alteration | | 1 1.0|
Infiltration Cellular, Mononuclear | | |
Cell | | 3 1.3|
Inflammation, Chronic Active | 2 1 1 1 1 1 1 1 1 1 1 | 26 1.1|
Vacuolization Cytoplasmic | 2 1 1 1 2 | 15 1.2|
Acinus, Hyperplasia | 1 | 1 1.0|
Artery, Fibrosis | | 1 4.0|
Artery, Polyarteritis | 4 | 3 3.3|
Duct, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Palate, Hyperkeratosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + M + | 59 |
Duct, Submandibular Gland, | | |
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + M + + + + + + + + + + + + + + + + | 69 |
Erosion | | 1 3.0|
Fibrosis | | 1 2.0|
Hyperkeratosis | 2 2 2 1 2 | 20 2.0|
Hyperplasia, Basal Cell | 2 2 2 3 1 2 | 23 2.1|
Hyperplasia, Squamous | 3 3 2 3 2 3 3 | 26 3.0|
Inflammation, Chronic Active | 2 | 11 2.2|
Ulcer | 2 2 1 1 3 | 16 2.6|
Arteriole, Mineralization | | 1 1.0|
Muscularis, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | | 2 2.5|
Inflammation, Chronic Active | | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 136
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 3| 6| 5| 4| 3| 2| 7| 7| 7| 6| 6| 7| 6| 6| 6| 4| | |
DAY ON TEST | 2| 0| 2| 3| 5| 4| 5| 5| 6| 7| 2| 2| 0| 7| 0| 2| 7| 7| 3| 5| | |
| 9| 3| 5| 6| 2| 6| 2| 6| 4| 5| 9| 9| 2| 4| 5| 9| 4| 1| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + | 59 |
Cardiomyopathy | 1 1 2 1 1 2 2 1 1 1 2 1 1 2 2 2 2 | 54 1.5|
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + | 60 |
Angiectasis | 2 2 1 2 1 | 15 1.3|
Autolysis | | 2 2.5|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | 1 | 1 1.0|
Vacuolization Cytoplasmic | 2 2 | 11 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + | 60 |
Autolysis | | 2 2.5|
Hyperplasia | 1 1 1 1 2 2 1 | 21 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + | 50 |
Autolysis | | 1 2.0|
Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + | 54 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + | 58 |
Autolysis | | 1 3.0|
Cyst | | 1 1.0|
Pars Distalis, Cyst | 2 1 | 9 1.4|
Pars Distalis, Hyperplasia | 2 2 1 2 1 1 2 2 | 32 1.5|
Pars Intermedia, Cyst | | 2 1.0|
Pars Nervosa, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + | 61 |
Autolysis | | 2 3.0|
Ultimobranchial Cyst | | 2 1.5|
C-Cell, Hyperplasia | 1 1 | 4 1.0|
Follicle, Cyst | 2 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 137
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 3| 6| 5| 4| 3| 2| 7| 7| 7| 6| 6| 7| 6| 6| 6| 4| | |
DAY ON TEST | 2| 0| 2| 3| 5| 4| 5| 5| 6| 7| 2| 2| 0| 7| 0| 2| 7| 7| 3| 5| | |
| 9| 3| 5| 6| 2| 6| 2| 6| 4| 5| 9| 9| 2| 4| 5| 9| 4| 1| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 3 | 3 1.7|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + M | 56 |
Cyst | | 1 2.0|
Inflammation, Chronic | 1 | 2 1.0|
Inflammation, Chronic Active | 2 1 2 3 2 4 1 2 1 2 2 2 1 2 2 | 45 1.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + | 59 |
Abscess | | 1 4.0|
Fibrosis | | 1 2.0|
Inflammation, Chronic Active | 2 3 2 2 1 1 2 3 | 24 2.1|
Metaplasia, Squamous | | 1 3.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + | 60 |
Atrophy | 3 3 3 3 2 3 3 3 3 | 23 2.8|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + | 68 |
Abscess, Chronic | | 1 3.0|
Atrophy | | 1 4.0|
Infarct, Chronic | | 1 4.0|
Infarct | | 1 4.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 | 32 1.2|
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 4 4 1 4 3 4 4 | 39 3.5|
Seminiferous Tubule, Mineralization | 1 | 6 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + | 60 |
Sternal, Hypoplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + M + + + + + | 25 |
Deep Cervical, Hyperplasia | | 1 2.0|
Lumbar, Hyperplasia | | 1 1.0|
Mediastinal, Hemorrhage | | 2 1.5|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 1 | 2 1.0|
Mediastinal, Pigmentation | | 3 1.3|
Pancreatic, Hyperplasia | | 2 2.5|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 2 3 3 2 2 2 | 23 2.3|
Pancreatic, Pigmentation | | 4 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 138
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 3| 6| 5| 4| 3| 2| 7| 7| 7| 6| 6| 7| 6| 6| 6| 4| | |
DAY ON TEST | 2| 0| 2| 3| 5| 4| 5| 5| 6| 7| 2| 2| 0| 7| 0| 2| 7| 7| 3| 5| | |
| 9| 3| 5| 6| 2| 6| 2| 6| 4| 5| 9| 9| 2| 4| 5| 9| 4| 1| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + | 59 |
Hemorrhage | 3 | 8 1.5|
Hyperplasia | 3 | 4 2.3|
Infiltration Cellular, Histiocyte | 1 2 | 8 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + | 60 |
Hyperplasia | 2 | 2 2.5|
Infiltration Cellular, Histiocyte | 3 1 1 1 1 2 1 2 1 1 2 1 1 1 2 1 1 1 | 60 1.3|
Pigmentation | 1 | 7 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + | 62 |
Autolysis | 3 | 2 3.0|
Depletion Lymphoid | | 2 3.0|
Fibrosis | 2 1 | 5 2.2|
Infiltration Cellular, Histiocyte | | 1 1.0|
Pigmentation | | 2 1.5|
__________________________________________________________________________|____________|
Thymus | + M M + + M + + + + + + + + + + M + M + | 53 |
Depletion Lymphoid | | 10 1.9|
Hemorrhage | 1 | 5 1.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M M + + + M M + + + + + M M M M | 29 |
Hyperplasia | 1 1 2 1 1 | 17 1.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + | 60 |
Cranium, Abscess | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Spinal Cord | + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + | 62 |
Foreign Body | 1 | 1 1.0|
Hemorrhage | 1 | 2 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 | 26 1.0|
Inflammation, Chronic Active | 1 | 3 1.3|
Metaplasia, Osseous | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 139
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 3| 6| 5| 4| 3| 2| 7| 7| 7| 6| 6| 7| 6| 6| 6| 4| | |
DAY ON TEST | 2| 0| 2| 3| 5| 4| 5| 5| 6| 7| 2| 2| 0| 7| 0| 2| 7| 7| 3| 5| | |
| 9| 3| 5| 6| 2| 6| 2| 6| 4| 5| 9| 9| 2| 4| 5| 9| 4| 1| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 | 34 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + | 60 |
Foreign Body | | 1 2.0|
Hemorrhage | | 3 2.3|
Inflammation, Chronic Active | 3 1 2 1 1 1 2 1 | 18 1.9|
Metaplasia, Squamous | 2 1 | 6 1.7|
Glands, Hyperplasia | 1 | 3 1.7|
Respiratory Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
Inflammation, Chronic Active | | 2 1.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Submucosa, Abscess | | 1 2.0|
__________________________________________________________________________|____________|
Eye | + + + + | 6 |
Synechia | 4 | 1 4.0|
Lens, Cataract | 2 4 4 | 3 3.3|
Retina, Degeneration | 3 4 4 | 3 3.7|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | 3 | 4 3.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 | 9 1.1|
Nephropathy | 3 3 2 2 3 3 3 2 3 3 3 3 3 3 2 3 3 2 | 59 2.7|
Renal Tubule, Degeneration, Hyaline | 2 | 11 2.0|
Renal Tubule, Hyperplasia | 2 1 4 2 2 4 | 21 2.8|
Renal Tubule, Hyperplasia, Oncocytic | 1 | 1 1.0|
Renal Tubule, Inflammation, Chronic | | |
Active | 1 1 1 1 1 1 | 14 1.0|
Renal Tubule, Mineralization | 1 | 4 1.0|
Renal Tubule, Pigmentation | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 69 1.9|
Renal Tubule, Regeneration | 2 | 9 1.8|
Transitional Epithelium, Hyperplasia | 2 2 1 1 1 2 2 2 1 1 1 2 1 | 39 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 70 |
Autolysis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 140
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 3| 6| 5| 4| 3| 2| 7| 7| 7| 6| 6| 7| 6| 6| 6| 4| | |
DAY ON TEST | 2| 0| 2| 3| 5| 4| 5| 5| 6| 7| 2| 2| 0| 7| 0| 2| 7| 7| 3| 5| | |
| 9| 3| 5| 6| 2| 6| 2| 6| 4| 5| 9| 9| 2| 4| 5| 9| 4| 1| 1| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.0% | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
71MHM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 1 1 | 5 1.2|
Metaplasia, Squamous | | 1 2.0|
Transitional Epithelium, Hyperplasia | 3 3 2 3 3 3 4 2 2 2 2 2 1 2 1 | 33 2.1|
Transitional Epithelium, Metaplasia, | | |
Squamous | 2 1 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 141
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2|
DAY ON TEST | 5| 5| 2| 5| 5| 5| 5| 5| 7| 7| 5| 5| 5| 7| 7| 5| 5| 2| 7| 7| 5| 5| 0| 7| 7|
| 6| 7| 7| 6| 8| 7| 7| 7| 4| 5| 8| 6| 6| 5| 4| 7| 6| 3| 4| 4| 8| 6| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2.0% | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + M + + + + + + + + + +|
Inflammation, Chronic Active | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 1 2 1 1 2 1 2 1 2 2 2 1 1 1|
Clear Cell Focus | 1 1 1 1 1 1 1 1 1 1 2 1 1 2 |
Cytomegaly | 1 1 |
Degeneration | 1 1 1 |
Eosinophilic Focus | 2 1 |
Fatty Change | 1 1 1 1 1 1 3 |
Hemorrhage | 2 |
Inflammation, Chronic Active | 1 1 |
Mixed Cell Focus | 2 |
Necrosis, Coagulative | 1 1 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Bile Duct, Hyperplasia | 2 1 1 2 1 2 1 1 1 1 1 1 1 1 1 2 1 2 2 1 1|
Periportal, Inflammation, Chronic | 2 2 2 1 2 2 1 2 2 2 2 2 2 2 |
Periportal, Inflammation, Chronic | |
Active | 1 2 1 2 1 2 2 2 2|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | 4 |
Necrosis, Coagulative | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 |
Ectopic Tissue | 1 |
Hyperplasia | 1 |
Infiltration Cellular, Mononuclear | |
Cell | 1 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Chronic | 1 1 1 1 1 4 1 1 1 |
Inflammation, Chronic Active | |
Pigmentation | 1 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +|
Duct, Parotid Gland, Mineralization | 1 |
Sublingual Gland, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 142
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2|
DAY ON TEST | 5| 5| 2| 5| 5| 5| 5| 5| 7| 7| 5| 5| 5| 7| 7| 5| 5| 2| 7| 7| 5| 5| 0| 7| 7|
| 6| 7| 7| 6| 8| 7| 7| 7| 4| 5| 8| 6| 6| 5| 4| 7| 6| 3| 4| 4| 8| 6| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2.0% | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Sublingual Gland, Pigmentation | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 |
Hyperkeratosis | 1 |
Hyperplasia, Basal Cell | 1 2 1 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Arteriole, Mineralization | |
Muscularis, Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 2 2 1 1 1 2 2 2 2 1 2 1 1 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Vacuolization Cytoplasmic | 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 3 2 2 |
Pars Distalis, Hyperplasia | 2 1 1 3 2 2 1 1 1 2 1 1 2 2 2 1 1 2 |
Pars Nervosa, Cyst | 2 |
Pars Nervosa, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 2 1 1 1 1 2 1 1 1 1 2 1 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 1 1 1 2 1 2 1 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 143
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2|
DAY ON TEST | 5| 5| 2| 5| 5| 5| 5| 5| 7| 7| 5| 5| 5| 7| 7| 5| 5| 2| 7| 7| 5| 5| 0| 7| 7|
| 6| 7| 7| 6| 8| 7| 7| 7| 4| 5| 8| 6| 6| 5| 4| 7| 6| 3| 4| 4| 8| 6| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2.0% | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 2 3 1 2 1 2 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Chronic | 3 |
Atrophy | 4 |
Infarct | 4 |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 4 |
Interstitial Cell, Hyperplasia | 2 2 2 1 2 2 1 1 1 1 1 1 1 1 1 1|
Seminiferous Tubule, Atrophy | 4 1 1 1 4 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + M M + M M M + M +|
Mediastinal, Hemorrhage | 2 2 |
Mediastinal, Pigmentation | 1 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 2 |
Pancreatic, Pigmentation | 2 1 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + M + + + + + + + + + + + + + + + + + M + +|
Hemorrhage | 2 2 1 |
Hyperplasia, Plasma Cell | 2 |
Infiltration Cellular, Histiocyte | 1 1 |
Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 2 1 1 1 2 1 2 2 2 1 1 1 2 1 1 3 1 1 1 1 2 2 2 1 2|
Pigmentation | 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + M + + M + + + + + + + M + + + + + + + + +|
Depletion Lymphoid | 2 1 2 3 2 3 2 2 3 3 2 2 3 3 2 2 3|
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + M + + + M M M M + M + + M + M + + M M|
Hyperplasia | 1 1 2 2 2 1 2 1 1 1 2 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 144
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2|
DAY ON TEST | 5| 5| 2| 5| 5| 5| 5| 5| 7| 7| 5| 5| 5| 7| 7| 5| 5| 2| 7| 7| 5| 5| 0| 7| 7|
| 6| 7| 7| 6| 8| 7| 7| 7| 4| 5| 8| 6| 6| 5| 4| 7| 6| 3| 4| 4| 8| 6| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2.0% | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 |
Mineralization | 1 |
Alveolar Epithelium, Hyperplasia | |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Inflammation, Acute | 2 1 1 3 3 1 |
Glands, Inflammation, Chronic Active | 2 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | M M M M + M M M M|
Conjunctiva, Inflammation, Chronic | |
Active | 1 |
Cornea, Fibrosis | 2 |
Cornea, Neovascularization | 2 |
__________________________________________________________________________|
Harderian Gland | M M M M M M M M|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Infiltration Cellular, Mononuclear | |
Cell | 1 1 1 1 1 |
Infiltration Cellular, Mixed Cell | 1 |
Nephropathy | 2 2 1 3 3 2 2 3 3 3 2 2 3 2 3 3 2 |
Renal Tubule, Degeneration, Hyaline | 2 2 2 3 2 2 2 2|
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Inflammation, Chronic | |
Active | 2 |
Renal Tubule, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Renal Tubule, Regeneration | 2 2 2 1 2 2 1 2|
Transitional Epithelium, Hyperplasia | 2 1 1 1 1 1 2 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | 2 1 |
Inflammation, Chronic | 1 |
Fat, Proliferation | 3 |
_____________________________________________________________________________________________________________________|
Page 145
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2| 4| 4| 4| 2| 2|
DAY ON TEST | 5| 5| 2| 5| 5| 5| 5| 5| 7| 7| 5| 5| 5| 7| 7| 5| 5| 2| 7| 7| 5| 5| 0| 7| 7|
| 6| 7| 7| 6| 8| 7| 7| 7| 4| 5| 8| 6| 6| 5| 4| 7| 6| 3| 4| 4| 8| 6| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
2.0% | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
71HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Muscularis, Mineralization | 1 |
Transitional Epithelium, Hyperplasia | 2 1 2 3 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 146
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 2| 2| | |
DAY ON TEST | 5| 5| 5| 7| 7| | |
| 7| 8| 7| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
2.0% | 0| 0| 0| 0| 0| | L |
71HM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 30 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 30 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 30 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 28 |
Inflammation, Chronic Active | 3 | 1 3.0|
Parasite Metazoan | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 29 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 29 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 29 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + | 30 |
Basophilic Focus | 2 2 1 | 19 1.5|
Clear Cell Focus | 2 1 1 | 17 1.2|
Cytomegaly | | 2 1.0|
Degeneration | 1 | 4 1.0|
Eosinophilic Focus | | 2 1.5|
Fatty Change | 1 1 1 | 10 1.2|
Hemorrhage | | 1 2.0|
Inflammation, Chronic Active | | 2 1.0|
Mixed Cell Focus | | 1 2.0|
Necrosis, Coagulative | 1 1 | 4 1.0|
Pigmentation | 1 1 1 1 1 | 28 1.0|
Bile Duct, Hyperplasia | 1 2 1 1 2 | 26 1.3|
Periportal, Inflammation, Chronic | 2 2 2 | 17 1.9|
Periportal, Inflammation, Chronic | | |
Active | 1 2 | 11 1.6|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Inflammation, Chronic Active | | 1 4.0|
Necrosis, Coagulative | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 30 |
Atrophy | 2 3 | 4 2.0|
Ectopic Tissue | | 1 1.0|
Hyperplasia | | 1 1.0|
Infiltration Cellular, Mononuclear | | |
Cell | | 1 1.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Chronic | 1 2 | 11 1.4|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 147
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 2| 2| | |
DAY ON TEST | 5| 5| 5| 7| 7| | |
| 7| 8| 7| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
2.0% | 0| 0| 0| 0| 0| | L |
71HM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Pigmentation | | 1 1.0|
Artery, Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 29 |
Duct, Parotid Gland, Mineralization | | 1 1.0|
Sublingual Gland, Atrophy | | 1 2.0|
Sublingual Gland, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 30 |
Acanthosis | | 2 2.0|
Hyperkeratosis | | 1 1.0|
Hyperplasia, Basal Cell | | 3 1.3|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 30 |
Inflammation, Chronic | | 1 1.0|
Arteriole, Mineralization | 1 | 1 1.0|
Muscularis, Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 30 |
Cardiomyopathy | 1 2 2 1 | 23 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 30 |
Angiectasis | | 1 1.0|
Vacuolization Cytoplasmic | 1 2 | 6 1.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 30 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 30 |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + | 29 |
Pars Distalis, Cyst | | 3 2.3|
Pars Distalis, Hyperplasia | 2 1 | 20 1.6|
Pars Nervosa, Cyst | | 1 2.0|
Pars Nervosa, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 30 |
Ultimobranchial Cyst | | 1 1.0|
C-Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 148
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 2| 2| | |
DAY ON TEST | 5| 5| 5| 7| 7| | |
| 7| 8| 7| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
2.0% | 0| 0| 0| 0| 0| | L |
71HM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + | 30 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 29 |
Inflammation, Chronic | 2 | 8 1.1|
Inflammation, Chronic Active | 2 2 1 | 17 1.3|
__________________________________________________________________________|____________|
Prostate | + + + + + | 30 |
Inflammation, Acute | 1 1 2 | 11 1.4|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 2 | 7 1.9|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 30 |
__________________________________________________________________________|____________|
Testes | + + + + + | 30 |
Abscess, Chronic | | 1 3.0|
Atrophy | | 1 4.0|
Infarct | | 1 4.0|
Inflammation, Chronic | 2 | 2 2.5|
Inflammation, Chronic Active | | 1 4.0|
Interstitial Cell, Hyperplasia | 1 2 2 | 19 1.4|
Seminiferous Tubule, Atrophy | 4 | 7 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 30 |
__________________________________________________________________________|____________|
Lymph Node | M + | 6 |
Mediastinal, Hemorrhage | 1 | 3 1.7|
Mediastinal, Pigmentation | | 1 1.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 2 2.0|
Pancreatic, Pigmentation | | 3 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 27 |
Hemorrhage | 1 | 4 1.5|
Hyperplasia, Plasma Cell | | 1 2.0|
Infiltration Cellular, Histiocyte | | 2 1.0|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 30 |
Hemorrhage | 1 | 2 1.0|
Infiltration Cellular, Histiocyte | 2 1 1 2 1 | 30 1.5|
Pigmentation | 1 1 1 1 1 | 23 1.1|
__________________________________________________________________________|____________|
Spleen | + + + + + | 30 |
Depletion Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 149
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 2| 2| | |
DAY ON TEST | 5| 5| 5| 7| 7| | |
| 7| 8| 7| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
2.0% | 0| 0| 0| 0| 0| | L |
71HM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | M + + + + | 26 |
Depletion Lymphoid | 3 2 3 | 20 2.4|
Hemorrhage | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + M | 15 |
Hyperplasia | 2 | 14 1.4|
__________________________________________________________________________|____________|
Skin | + + M + + | 29 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 30 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 30 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 30 |
Infiltration Cellular, Histiocyte | | 7 1.0|
Mineralization | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Artery, Mineralization | 1 | 13 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 30 |
Glands, Inflammation, Acute | 1 1 | 8 1.6|
Glands, Inflammation, Chronic Active | 1 | 3 1.7|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 30 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | M M | 1 |
Conjunctiva, Inflammation, Chronic | | |
Active | | 1 1.0|
Cornea, Fibrosis | | 1 2.0|
Cornea, Neovascularization | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | M M | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 150
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 2| 2| | |
DAY ON TEST | 5| 5| 5| 7| 7| | |
| 7| 8| 7| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| | A |
2.0% | 0| 0| 0| 0| 0| | L |
71HM | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 30 |
Autolysis | | 1 3.0|
Infiltration Cellular, Mononuclear | | |
Cell | 1 1 | 7 1.0|
Infiltration Cellular, Mixed Cell | | 1 1.0|
Nephropathy | 3 3 3 | 20 2.5|
Renal Tubule, Degeneration, Hyaline | 2 2 | 10 2.1|
Renal Tubule, Hyperplasia | | 1 1.0|
Renal Tubule, Inflammation, Chronic | | |
Active | | 1 2.0|
Renal Tubule, Pigmentation | 2 2 2 2 2 | 30 2.0|
Renal Tubule, Regeneration | 2 2 | 10 1.8|
Transitional Epithelium, Hyperplasia | 1 1 | 11 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + M + | 28 |
Calculus Micro Observation Only | | 2 1.5|
Inflammation, Chronic | | 1 1.0|
Fat, Proliferation | | 1 3.0|
Muscularis, Mineralization | | 1 1.0|
Transitional Epithelium, Hyperplasia | 1 1 | 9 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 151
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 4| 5| 5| 5| 4| 1| | |
| 8| 8| 6| 8| 7| 6| 8| 8| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
2.0% | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
Parasite Metazoan | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
Parasite Metazoan | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + M + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Anisokaryosis | 2 | 1 2.0|
Basophilic Focus | 1 1 1 1 | 4 1.0|
Clear Cell Focus | 1 1 2 2 X 2 | 6 1.6|
Fatty Change | 1 1 3 2 1 1 1 3 4 | 9 1.9|
Hepatodiaphragmatic Nodule | X | 1 |
Necrosis, Coagulative | 1 | 1 1.0|
Pigmentation | 1 1 1 1 1 1 1 1 | 8 1.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 | 7 1.0|
Periportal, Inflammation, Chronic | 1 2 1 2 2 2 2 | 7 1.7|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Chronic | 3 | 1 3.0|
Thrombosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Atrophy | 1 1 | 2 1.0|
Inflammation, Chronic | 1 1 1 1 1 | 5 1.0|
Vacuolization Cytoplasmic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
Hyperkeratosis | 3 2 | 2 2.5|
Hyperplasia, Basal Cell | 2 2 | 2 2.0|
Hyperplasia, Squamous | 3 3 | 2 3.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Ulcer | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 152
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 4| 5| 5| 5| 4| 1| | |
| 8| 8| 6| 8| 7| 6| 8| 8| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
2.0% | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 2 2 2 1 1 2 1 1 | 8 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
Pars Distalis, Cyst | 1 | 1 1.0|
Pars Distalis, Hyperplasia | 1 1 1 2 2 2 | 6 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Ultimobranchial Cyst | 1 | 1 1.0|
C-Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
Vacuolization Cytoplasmic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
Inflammation, Chronic | 1 1 | 2 1.0|
Inflammation, Chronic Active | 1 2 1 1 1 1 2 | 7 1.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
Inflammation, Acute | 2 2 2 3 | 4 2.3|
Inflammation, Chronic Active | 3 1 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Abscess | 4 | 1 4.0|
Interstitial Cell, Hyperplasia | 2 2 1 1 1 1 1 1 | 8 1.3|
Seminiferous Tubule, Atrophy | 4 3 4 | 3 3.7|
Seminiferous Tubule, Mineralization | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
Myelofibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 153
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 4| 5| 5| 5| 4| 1| | |
| 8| 8| 6| 8| 7| 6| 8| 8| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
2.0% | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hemorrhage | 3 | 1 3.0|
Pancreatic, Hemorrhage | 1 | 1 1.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + M + | 8 |
Hemorrhage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M | 9 |
Infiltration Cellular, Histiocyte | 1 2 2 1 1 2 2 1 2 | 9 1.6|
Pigmentation | 1 1 1 1 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + | 9 |
Depletion Lymphoid | 3 2 3 2 | 4 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + + M + + + + | 7 |
Hyperplasia | 2 2 2 2 2 2 2 | 7 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 1 | 2 1.0|
Artery, Mineralization | 1 1 1 1 1 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Glands, Inflammation, Acute | 1 1 1 | 3 1.0|
Lumen, Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Cyst | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 154
NTP Experiment-Test: 05061-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1-AMINO-2,4-DIBROMOANTHRAQUINONE Date: 04/17/97
Route: DOSED FEED Time: 11:03:13
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
DAY ON TEST | 5| 5| 5| 5| 4| 5| 5| 5| 4| 1| | |
| 8| 8| 6| 8| 7| 6| 8| 8| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
2.0% | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 2 2 2 2 2 2 2 2 2 2 | 10 2.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
Renal Tubule, Pigmentation | 1 1 1 1 2 1 1 2 1 | 9 1.2|
Transitional Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 155
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