TR 383 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason 1-AMINO 2,4-DIBROMOANTHRAQUINONE DATE: 05/19/95
EXPERIMENT: 05061 TEST: 01 TIME: 15:26:42
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES9561903 ROUTE: DOSED FEED NTP C#: 55458
PATHOLOGIST: R. FLEISCHMAN CAS: 81-49-2
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason 1-AMINO 2,4-DIBROMOANTHRAQUINONE DATE: 05/19/95
EXPERIMENT: 05061 TEST: 01 TIME: 15:26:42
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES9561903 ROUTE: DOSED FEED NTP C#: 55458
PATHOLOGIST: R. FLEISCHMAN CAS: 81-49-2
1-AMINO 2,4-DIBROMOANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATED 71 UM |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 24 CENSORED DEATHS 20 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 421 427 435 514 549 556 562 573 574 587 |
| 631 646 654 666 671 674 674 679 692 696 |
| 707 721 721 727 |
| CENSORED DEATHS |
| 273 274 275 275 275 275 276 276 276 276 |
| 456 456 456 456 456 456 456 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.2% 71 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 10 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 604 618 629 640 650 653 659 668 673 674 |
| 675 693 694 700 718 720 |
| CENSORED DEATHS |
| 274 274 274 274 275 276 276 276 276 276 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5% 71M |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 39 CENSORED DEATHS 10 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 465 478 521 521 563 576 582 584 605 608 |
| 609 623 629 629 636 636 637 650 650 652 |
| 653 659 661 674 674 674 685 687 693 698 |
| 700 700 702 709 712 714 715 720 728 |
| CENSORED DEATHS |
| 274 274 274 274 274 275 275 276 276 276 |
| |
==================================================================================
1-AMINO 2,4-DIBROMOANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1.0% 71M |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 40 CENSORED DEATHS 20 TERMINAL 10 |
| |
| UNCENSORED DEATHS |
| 281 352 364 435 436 476 493 497 527 542 |
| 552 553 573 577 581 588 590 591 596 605 |
| 610 622 624 625 631 631 646 671 674 674 |
| 679 689 702 703 709 714 715 721 724 724 |
| CENSORED DEATHS |
| 274 274 274 275 275 275 275 276 276 276 |
| 456 456 456 456 456 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.0% 71 |
| --------------------- |
| |
| TOTAL 30 UNCENSORED DEATHS 3 CENSORED DEATHS 27 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 400 423 427 |
| CENSORED DEATHS |
| 273 274 274 274 274 274 274 275 275 275 |
| 456 456 456 456 456 456 457 457 457 457 |
| 457 457 457 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.0% |
| --------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 3 CENSORED DEATHS 7 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 414 442 447 |
| CENSORED DEATHS |
| 456 456 458 458 458 458 458 |
| |
==================================================================================
1-AMINO 2,4-DIBROMOANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATED | 100.0 100.0 100.0 100.0 98.3 95.0 93.0 80.9 74.8 52.6 |
|71 UM | |
| | |
|0.2% 71| 100.0 100.0 100.0 100.0 100.0 100.0 100.0 97.5 82.5 60.0 |
| | |
| | |
|0.5% 71M| 100.0 100.0 100.0 100.0 100.0 96.7 93.3 85.0 61.7 35.0 |
| | |
| | |
|1.0% 71M| 100.0 100.0 100.0 95.0 95.0 89.6 81.5 61.1 46.9 20.4 |
| | |
| | |
|2.0% 71 | 100.0 100.0 100.0 100.0 90.0 0.0 0.0 0.0 0.0 0.0 |
| | |
| | |
|2.0% | 100.0 100.0 100.0 100.0 90.0 0.0 0.0 0.0 0.0 0.0 |
| | |
| | |
==================================================================================
1-AMINO 2,4-DIBROMOANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATED 0.2% 71 0.5% 71M 1.0% 71M 2.0% 71 2.0% |
| 71 UM |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 52.6% 60.0% 35.0% 20.4% 0.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.467N P=0.141 P<0.001 P=0.303 P=0.041 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 614.9 666.8 641.3 592.4 416.7 434.3 |
|NATURAL DEATHS (C) | (19.3) ( 8.5) (10.6) (17.2) ( 8.4) (10.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 586.1 618.3 615.3 547.2 392.0 450.5 |
|(STANDARD ERROR) | (19.8) (25.0) (18.3) (18.8) (15.6) ( 4.4) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
1-AMINO 2,4-DIBROMOANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATED 71UF |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 12 CENSORED DEATHS 20 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 268 601 606 620 642 656 658 675 704 708 |
| 716 719 |
| CENSORED DEATHS |
| 279 279 279 281 281 281 281 281 281 281 |
| 462 462 462 462 462 462 462 462 462 464 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.2% 71 |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 10 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 600 611 616 659 661 664 670 689 |
| CENSORED DEATHS |
| 279 279 281 281 281 281 281 281 281 281 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5% 71M |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 22 CENSORED DEATHS 10 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 575 582 601 606 609 632 642 647 649 649 |
| 660 660 667 670 691 695 696 708 714 716 |
| 719 725 |
| CENSORED DEATHS |
| 279 279 279 279 279 281 281 281 281 281 |
| |
==================================================================================
1-AMINO 2,4-DIBROMOANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1.0% 71M |
| --------------------- |
| |
| TOTAL 69 UNCENSORED DEATHS 37 CENSORED DEATHS 20 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 367 418 460 512 543 559 566 569 576 580 |
| 598 600 610 614 616 625 635 636 636 637 |
| 638 658 662 662 664 673 674 685 695 702 |
| 702 705 714 715 719 720 722 |
| CENSORED DEATHS |
| 279 279 279 279 279 279 279 281 281 281 |
| 462 462 462 462 462 462 464 464 464 464 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.0% 71 |
| --------------------- |
| |
| TOTAL 29 UNCENSORED DEATHS 8 CENSORED DEATHS 21 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 294 299 306 313 426 429 441 461 |
| CENSORED DEATHS |
| 279 279 279 279 279 279 279 279 281 281 |
| 462 462 462 462 462 464 464 464 464 464 |
| 464 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.0% |
| --------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 1 CENSORED DEATHS 9 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 456 |
| CENSORED DEATHS |
| 462 462 462 464 464 464 464 464 464 |
| |
==================================================================================
1-AMINO 2,4-DIBROMOANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATED | 100.0 100.0 98.6 98.6 98.6 98.6 98.6 96.6 86.5 76.4 |
|71UF | |
| | |
|0.2% 71 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 97.5 85.0 80.0 |
| | |
| | |
|0.5% 71M| 100.0 100.0 100.0 100.0 100.0 100.0 100.0 95.0 80.0 63.3 |
| | |
| | |
|1.0% 71M| 100.0 100.0 100.0 100.0 96.6 94.9 90.8 76.3 49.5 24.8 |
| | |
| | |
|2.0% 71 | 100.0 100.0 100.0 78.9 78.9 57.9 0.0 0.0 0.0 0.0 |
| | |
| | |
|2.0% | 100.0 100.0 100.0 100.0 100.0 90.0 0.0 0.0 0.0 0.0 |
| | |
| | |
==================================================================================
1-AMINO 2,4-DIBROMOANTHRAQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATED 0.2% 71 0.5% 71M 1.0% 71M 2.0% 71 2.0% |
| 71UF |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 76.4% 80.0% 63.3% 24.8% 0.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.857N P=0.216 P<0.001 P<0.001 P=0.634 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 631.1 646.3 659.7 623.4 371.1 456.0 |
|NATURAL DEATHS (C) | (35.1) (11.5) ( 9.7) (13.8) (26.1) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 610.0 626.1 643.1 568.7 374.4 462.6 |
|(STANDARD ERROR) | (20.4) (25.1) (18.5) (18.6) (16.3) ( 0.8) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
1-AMINO 2,4-DIBROMOANTHRAQUINONE
KAPLAN-MEIER SURVIVAL CURVES
UNTREATED 71 UM = 1
0.2% 71 = 2
0.5% 71M = 3
1.0% 71M = 4
2.0% 71 = 5
2.0% = 6
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
100 + 1 4 5 61 3 2
| 4 44 1 1 3 3 3 2 2
| 4 5 5 1 1 22
| 4 4 1 3 1 3 3 2 2
90 + 6 6 4 4 111 33 22
| 11 3 3 22
| 5 5 4 4 2 2
| 4 44 1 1 3 3 22
80 + 1 331 1 22
| 4 4 33 11
| 44 1 1
| 44 3 3 2 2
P 70 + 6 6 4 4 11 22
E | 33
R | 44 3 3 1 12 2
C | 44 3 3 11
E 60 + 444 11 2 2
N | 44 33 1 1
T | 33 11
| 44 33 1 1
S 50 + 4 4
U | 4 4 33
R | 44 33
V |
I 40 + 33
V | 4 4 4 33
A | 3 3
L | 44
30 +
| 44
| 44
|
20 + 4 4
|
|
|
10 +
|
|
|
0 + 5
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 15 obs hidden.
1-AMINO 2,4-DIBROMOANTHRAQUINONE
KAPLAN-MEIER SURVIVAL CURVES
UNTREATED 71UF = 1
0.2% 71 = 2
0.5% 71M = 3
1.0% 71M = 4
2.0% 71 = 5
2.0% = 6
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
100 + 1 1 5 4 6 3 2
| 1 4 4 4 33 112
| 55 4 4 31 1
| 4 4 321 31 2
90 + 55 6 6 4 4 31 1
| 444 331 1
| 5 5 44 221 1
| 3 32 2 11
80 + 5 5 4 4 33 2 11 2
| 4 4 3 3 1 1
| 33
| 55 3 3
P 70 + 4 4
E | 55 44 33
R | 33
C | 5 5 3 3
E 60 + 44
N | 5 5 4 4
T | 4 4
|
S 50 + 4 4
U |
R | 44
V | 4 44
I 40 +
V |
A | 44
L | 44
30 +
| 44
| 4 4
|
20 +
|
|
|
10 +
|
|
|
0 + 5
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 15 obs hidden.
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