TR 386 Mouse Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
TETRANITROMETHANE
NTP Experiment-Test: 05072-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:17:53
Facility: Midwest Research Institute
Chemical CAS #: 509-14-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05072-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:17:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.5 PPM 2 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Natural Death 5 4 10
Accidently Killed 2 1
Moribund Sacrifice 12 17 16
Survivors
Terminal Sacrifice 30 27 23
Natural Death 1
Moribund Sacrifice 1 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (49) (49)
Gallbladder (42) (40) (36)
Intestine Large, Cecum (47) (44) (45)
Intestine Large, Colon (49) (47) (46)
Intestine Large, Rectum (46) (48) (48)
Liver (49) (50) (50)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Metastatic, Spleen 2 (4%)
Hepatocellular Carcinoma 4 (8%) 2 (4%) 3 (6%)
Hepatocellular Adenoma 8 (16%) 1 (2%) 4 (8%)
Hepatocellular Adenoma, Multiple 1 (2%)
Mesentery (3) (1) (5)
Pancreas (49) (50) (50)
Salivary Glands (48) (50) (50)
Stomach, Forestomach (48) (50) (49)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (47) (49) (49)
Tooth (2) (2)
Peridontal Tissue, Alveolar/Bronchiolar
Carcinoma, Metastatic, Lung 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (47) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%) 5 (10%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05072-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:17:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.5 PPM 2 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (49) (50)
Extra Adrenal Tissue, Alveolar/Bronchiolar
Carcinoma, Metastatic, Lung 1 (2%)
Subcapsular, Adenoma 1 (2%)
Adrenal Gland, Cortex (49) (48) (50)
Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%) 1 (2%)
Adrenal Gland, Medulla (48) (46) (47)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Pheochromocytoma Benign 1 (2%) 1 (2%)
Islets, Pancreatic (49) (50) (49)
Adenoma 3 (6%)
Parathyroid Gland (39) (38) (40)
Adenoma 1 (3%)
Pituitary Gland (49) (49) (48)
Pars Distalis, Adenoma 18 (37%) 18 (37%) 13 (27%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Pars Distalis, Adenoma, Two 1 (2%)
Pars Distalis, Carcinoma 2 (4%)
Thyroid Gland (48) (50) (50)
Follicular Cell, Adenoma 2 (4%) 1 (2%) 3 (6%)
Follicular Cell, Adenoma, Multiple 1 (2%)
Follicular Cell, Adenoma, Two 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 2 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (48) (49) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 2 (4%)
Luteoma 1 (2%)
Uterus (49) (50) (50)
Adenocarcinoma 1 (2%)
Carcinoma 1 (2%)
Hemangiosarcoma 2 (4%) 1 (2%) 1 (2%)
Polyp Stromal 1 (2%) 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05072-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:17:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.5 PPM 2 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (50) (50)
Hemangioma 1 (2%)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Lymph Node (50) (50) (50)
Bronchial, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%) 1 (2%)
Lymph Node, Mandibular (48) (43) (45)
Sarcoma, Metastatic, Skin 1 (2%)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Lymph Node, Mesenteric (41) (36) (37)
Spleen (48) (49) (50)
Hemangiosarcoma 4 (8%)
Thymus (48) (44) (32)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (46) (45)
Adenocarcinoma 1 (2%) 1 (2%)
Skin (48) (46) (50)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma,
Metastatic, Spleen 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Metastatic, Lung 1 (2%)
Osteosarcoma 1 (2%)
Skeletal Muscle (2) (1)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05072-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:17:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.5 PPM 2 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (46) (45) (47)
Lung (49) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 12 (24%) 10 (20%)
Alveolar/Bronchiolar Adenoma, Multiple 7 (14%) 31 (62%)
Alveolar/Bronchiolar Carcinoma 3 (6%) 8 (16%) 5 (10%)
Alveolar/Bronchiolar Carcinoma, Multiple 3 (6%) 40 (80%)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Osteosarcoma, Multiple, Metastatic, Bone 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 2 (4%)
Nose (49) (50) (50)
Mucosa, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Trachea (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (1) (1)
Adenoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 3 (6%)
Bilateral, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Ureter (1)
Urinary Bladder (48) (49) (47)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Histiocytic 1 (2%) 1 (2%)
Lymphoma Malignant Lymphocytic 3 (6%) 4 (8%) 3 (6%)
Lymphoma Malignant Mixed 7 (14%) 5 (10%) 8 (16%)
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05072-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:17:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.5 PPM 2 PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Undifferentiated Cell 1 (2%) 3 (6%) 3 (6%)
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 05072-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:17:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.5 PPM 2 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 40 44 49
Total Primary Neoplasms 63 79 137
Total Animals with Benign Neoplasms 29 36 45
Total Benign Neoplasms 38 49 65
Total Animals with Malignant Neoplasms 22 24 47
Total Malignant Neoplasms 25 30 72
Total Animals with Metastatic Neoplasms 2 1 11
Total Metastatic Neoplasm 2 3 31
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05072-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:17:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.5 PPM 2 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund Sacrifice 9 19 17
Natural Death 4 3 18
Accidently Killed 2
Survivors
Terminal Sacrifice 37 26 15
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (49) (48) (44)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Intestine Small, Ileum (45) (47) (44)
Intestine Small, Jejunum (46) (46) (42)
Adenocarcinoma 1 (2%)
Liver (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%) 1 (2%)
Hemangioma 1 (2%)
Hemangiosarcoma 3 (6%) 3 (6%) 1 (2%)
Hemangiosarcoma, Multiple 1 (2%)
Hepatocellular Carcinoma 10 (20%) 8 (16%) 11 (22%)
Hepatocellular Carcinoma, Multiple 3 (6%) 3 (6%)
Hepatocellular Adenoma 7 (14%) 12 (24%) 2 (4%)
Hepatocellular Adenoma, Multiple 3 (6%) 3 (6%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Mesentery (3) (1)
Pancreas (50) (49) (49)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%) 2 (4%)
Duct, Adenocarcinoma 1 (2%)
Salivary Glands (50) (48) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%) 13 (26%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05072-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:17:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.5 PPM 2 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (49) (50)
Subcapsular, Adenoma 1 (2%) 2 (4%)
Adrenal Gland, Cortex (49) (47) (50)
Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%) 3 (6%)
Adrenal Gland, Medulla (47) (43) (47)
Pheochromocytoma Malignant 1 (2%)
Pituitary Gland (48) (48) (48)
Pars Distalis, Adenoma 1 (2%)
Thyroid Gland (50) (48) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Follicular Cell, Adenoma 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (7)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (100%) 7 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50)
Leiomyoma 1 (2%)
Prostate (48) (48) (46)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Seminal Vesicle (50) (50) (49)
Testes (50) (50) (50)
Interstitial Cell, Adenoma 1 (2%)
Tunic, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (50) (50) (50)
Bronchial, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Lumbar, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 4 (8%)
Page 9
NTP Experiment-Test: 05072-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:17:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.5 PPM 2 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Pancreatic, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Lymph Node, Mandibular (37) (39) (43)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 2 (5%)
Lymph Node, Mesenteric (46) (48) (39)
Histiocytic Sarcoma 2 (4%)
Pancreatic, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (3%)
Spleen (50) (49) (50)
Hemangiosarcoma 2 (4%) 3 (6%) 1 (2%)
Thymus (45) (38) (32)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 3 (9%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (48) (49) (49)
Prepuce, Subcutaneous Tissue,
Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Subcutaneous Tissue, Alveolar/Bronchiolar
Carcinoma, Metastatic, Lung 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (50)
Rib, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
Skeletal Muscle (6)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 5 (83%)
Diaphragm, Hemangiosarcoma 1 (17%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05072-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:17:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.5 PPM 2 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (46) (47)
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 7 (14%) 16 (32%) 13 (26%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) 21 (42%)
Alveolar/Bronchiolar Carcinoma 6 (12%) 9 (18%) 6 (12%)
Alveolar/Bronchiolar Carcinoma, Multiple 7 (14%) 40 (80%)
Hepatocellular Carcinoma, Metastatic, Liver 5 (10%) 3 (6%) 3 (6%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 7 (14%)
Mediastinum, Hepatocellular Carcinoma,
Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2) (1) (1)
Adenoma 2 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%) 8 (16%)
Urinary Bladder (48) (47) (47)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Histiocytic Sarcoma 2 (4%) 1 (2%)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Lymphocytic 2 (4%) 1 (2%)
Lymphoma Malignant Mixed 1 (2%) 1 (2%)
Lymphoma Malignant Undifferentiated Cell 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05072-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TETRANITROMETHANE Date: 09/09/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:17:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.5 PPM 2 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 39 40 48
Total Primary Neoplasms 55 79 101
Total Animals with Benign Neoplasms 20 26 37
Total Benign Neoplasms 24 38 39
Total Animals with Malignant Neoplasms 25 31 46
Total Malignant Neoplasms 31 41 62
Total Animals with Metastatic Neoplasms 6 4 18
Total Metastatic Neoplasm 6 13 65
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 12
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