TR 386 Mouse Pathology Tables
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
Facility: Midwest Research Institute
Chemical CAS #: 509-14-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 4| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 1| 2| 8| 3| 3| 3| 4| 3| 6| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 0| 3|
| 9| 9| 4| 9| 0| 0| 0| 0| 4| 0| 3| 0| 0| 0| 0| 0| 0| 7| 0| 7| 0| 0| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + M + +|
Inflammation, Focal, Granulomatous | 4 |
__________________________________________________________________________|
Liver | + + A + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X|
Eosinophilic Focus | |
Granuloma, Multifocal | 1 |
Hematopoietic Cell Proliferation, | |
Multifocal | 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 1 |
Inflammation, Multifocal, Subacute | 1 1 |
Necrosis, Acute, Multifocal | 1 3 |
Necrosis, Focal, Subacute | |
Vacuolization Cytoplasmic, Focal | |
Right Lateral Lobe, | |
Hepatodiaphragmatic Nodule | X |
__________________________________________________________________________|
Mesentery | + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 3 3 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 3 2 1 |
Acinus, Atrophy, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 2 2 1 3 2 1 1 1 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + A + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | 1 2 |
Epithelium, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 4| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 1| 2| 8| 3| 3| 3| 4| 3| 6| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 0| 3|
| 9| 9| 4| 9| 0| 0| 0| 0| 4| 0| 3| 0| 0| 0| 0| 0| 0| 7| 0| 7| 0| 0| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Abscess | 4 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
Inflammation, Acute, Multifocal | |
Epicardium, Inflammation, Chronic | |
Active, Focal | 2 |
Mitral Valve, Bacterium | 4 |
Mitral Valve, Inflammation, Chronic | |
Active | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + A + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Accessory Adrenal Cortical | |
Nodule | |
Capsule, Accessory Adrenal Cortical | |
Nodule, Multiple | |
Subcapsular, Hyperplasia, Diffuse | 3 3 3|
Subcapsular, Hyperplasia, Focal | |
Subcapsular, Hyperplasia, Multifocal | 2 2 2 3 3 2 2 2 3 3 3 2 3 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 4 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal | 2 2 4 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + M + + M + + + M + + + + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + A + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 4 |
Pars Distalis, Angiectasis | 2 3 2 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 |
Pars Distalis, Hyperplasia | 4 |
Pars Distalis, Hypertrophy, Focal | 2 3|
Pars Distalis, Hypertrophy, | |
Multifocal | |
__________________________________________________________________________|
Thyroid Gland | + + A + + + + + + + + + + + M + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 4| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 1| 2| 8| 3| 3| 3| 4| 3| 6| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 0| 3|
| 9| 9| 4| 9| 0| 0| 0| 0| 4| 0| 3| 0| 0| 0| 0| 0| 0| 7| 0| 7| 0| 0| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Inflammation, Acute, Focal | 1 |
Inflammation, Chronic, Multifocal | 1 3 |
Inflammation, Chronic Active, Focal | |
Inflammation, Chronic Active, | |
Multifocal | 3 |
C-Cell, Hyperplasia, Focal | |
Follicle, Cyst, Multiple | |
Follicular Cell, Hyperplasia, Diffuse| |
Follicular Cell, Hyperplasia, Focal | |
Follicular Cell, Hyperplasia, | |
Multifocal | 3 2 1 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Atrophy | |
Cyst, Multiple | |
__________________________________________________________________________|
Ovary | + + A + + + + + + + + + + + + M + + + + + + + + +|
Cyst | 4 3 4|
Thrombosis | 3|
Interstitium, Hyperplasia | |
Periovarian Tissue, Infiltration | |
Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Uterus | + + A + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | |
Amyloid Deposition | |
Angiectasis, Multifocal | 2 |
Hyperplasia, Cystic | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Thrombosis | 1 |
Bilateral, Hyperplasia, Cystic | 3 3 3 2 2 3 2 3 1 3 4 3 1 2 2 4 4 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | |
Renal, Hemorrhage, Subacute | 2 |
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Subacute | 1 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 4| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 1| 2| 8| 3| 3| 3| 4| 3| 6| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 0| 3|
| 9| 9| 4| 9| 0| 0| 0| 0| 4| 0| 3| 0| 0| 0| 0| 0| 0| 7| 0| 7| 0| 0| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia | 3 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M M + M + + + + + + + + M + + + + + + + + + + +|
Angiectasis | 3 |
Depletion Lymphoid | 4 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage, Acute | 1 2 2 2 2 |
Hemorrhage, Subacute | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + M + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hematopoietic Cell Proliferation | 1 3 4 4 |
Hyperplasia, Lymphoid | |
Infarct | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Depletion Lymphoid | 3 |
Ectopic Parathyroid Gland | 1 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + A + + + + + + + + + + + + + + + + + + + + + +|
Ectasia, Multifocal | 2 4 2 |
Hyperplasia, Diffuse | 2 2 2 2 |
Inflammation, Chronic Active, | |
Multifocal | 2 |
__________________________________________________________________________|
Skin | + + A + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Focal | 2 |
Inflammation, Chronic Active, | |
Multifocal | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + M + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 3 X 1 3 2 2 1|
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + A + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
Hemorrhage, Multifocal | |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 4| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 1| 2| 8| 3| 3| 3| 4| 3| 6| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 0| 3|
| 9| 9| 4| 9| 0| 0| 0| 0| 4| 0| 3| 0| 0| 0| 0| 0| 0| 7| 0| 7| 0| 0| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Mineralization, Multifocal | 2 3 2 2 3 2 2 2 2 2 3 2|
Perivascular, Infiltration Cellular, | |
Multifocal, Lymphocyte | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + M M M + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 |
__________________________________________________________________________|
Lung | + + A + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 2 2 1 2 2 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
Alveolus, Infiltration Cellular, | |
Diffuse, Histiocyte | |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | |
__________________________________________________________________________|
Nose | + + M + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 1 |
Mucosa, Inflammation, Chronic | 2 |
Mucosa, Inflammation, Chronic Active | 1 1 2 |
Mucosa, Ulcer | |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Olfactory Epithelium, Atrophy | 1 |
Respiratory Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + A + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Multifocal | 2 |
Infiltration Cellular, Lymphocyte | 1 2 1 2 2 1 1 |
Inflammation, Acute, Multifocal | |
Metaplasia, Focal, Osseous | |
__________________________________________________________________________|
Urinary Bladder | + + A + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 4| 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 2| 2| 1| 2| 8| 3| 3| 3| 4| 3| 6| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 0| 3|
| 9| 9| 4| 9| 0| 0| 0| 0| 4| 0| 3| 0| 0| 0| 0| 0| 0| 7| 0| 7| 0| 0| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 1 1 2 2|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 6| 6| 3| |
DAY ON TEST | 9| 3| 3| 3| 4| 3| 4| 2| 3| 3| 5| 0| 3| 1| 2| 2| 2| 1| 0| 2| 1| 2| 0| 2| 8| |
| 0| 0| 1| 1| 2| 1| 2| 9| 1| 1| 5| 4| 1| 9| 9| 9| 9| 3| 5| 9| 9| 9| 3| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + M + + + + + + + + M + + + + + M + + + + A A +| 42 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + M + + + + + + + + + + + + + + + + + + A + +| 47 |
Peyer's Patch, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + + + + + + + M| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A A +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + A M| 45 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + M + + + + + + + M + + + A +| 45 |
Inflammation, Focal, Granulomatous | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Basophilic Focus | | 1 |
Eosinophilic Focus | X X X | 3 |
Granuloma, Multifocal | | 1 1.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 1.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 4 1.3|
Inflammation, Multifocal, Subacute | 1 1 | 4 1.0|
Necrosis, Acute, Multifocal | 2 | 3 2.0|
Necrosis, Focal, Subacute | 1 2 | 2 1.5|
Vacuolization Cytoplasmic, Focal | 2 | 1 2.0|
Right Lateral Lobe, | | |
Hepatodiaphragmatic Nodule | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 3 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 2 1 2 | 10 1.5|
Acinus, Atrophy, Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2 2 2 3 2 2 3 2 1 2 1 1| 26 1.7|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Epithelium, Hyperplasia, Focal | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 6| 6| 3| |
DAY ON TEST | 9| 3| 3| 3| 4| 3| 4| 2| 3| 3| 5| 0| 3| 1| 2| 2| 2| 1| 0| 2| 1| 2| 0| 2| 8| |
| 0| 0| 1| 1| 2| 1| 2| 9| 1| 1| 5| 4| 1| 9| 9| 9| 9| 3| 5| 9| 9| 9| 3| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Abscess | | 1 4.0|
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cardiomyopathy | 1 | 1 1.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 1.0|
Inflammation, Acute, Multifocal | 2 | 1 2.0|
Epicardium, Inflammation, Chronic | | |
Active, Focal | | 1 2.0|
Mitral Valve, Bacterium | 4 | 2 4.0|
Mitral Valve, Inflammation, Chronic | | |
Active | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Accessory Adrenal Cortical | | |
Nodule | X | 1 |
Capsule, Accessory Adrenal Cortical | | |
Nodule, Multiple | X | 1 |
Subcapsular, Hyperplasia, Diffuse | 2 | 4 2.8|
Subcapsular, Hyperplasia, Focal | 1 | 1 1.0|
Subcapsular, Hyperplasia, Multifocal | 2 2 2 3 3 3 2 2 2 2 1 1 1 3 3 2 3 3 2 2 2 2 | 43 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Multifocal | 2| 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Hyperplasia, Focal | | 2 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Multifocal | 3 3 1 2 2 | 10 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + M M M + + + + + + + + + + M + + + + + + +| 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 2 4.0|
Pars Distalis, Angiectasis | 2 3 4 2 | 8 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 6| 6| 3| |
DAY ON TEST | 9| 3| 3| 3| 4| 3| 4| 2| 3| 3| 5| 0| 3| 1| 2| 2| 2| 1| 0| 2| 1| 2| 0| 2| 8| |
| 0| 0| 1| 1| 2| 1| 2| 9| 1| 1| 5| 4| 1| 9| 9| 9| 9| 3| 5| 9| 9| 9| 3| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia, Focal | 3 | 4 2.3|
Pars Distalis, Hyperplasia | | 1 4.0|
Pars Distalis, Hypertrophy, Focal | 2 2 2 | 5 2.2|
Pars Distalis, Hypertrophy, | | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 | 3 2.0|
Inflammation, Acute, Focal | | 1 1.0|
Inflammation, Chronic, Multifocal | 2 2 | 4 2.0|
Inflammation, Chronic Active, Focal | 2 | 1 2.0|
Inflammation, Chronic Active, | | |
Multifocal | 1 | 2 2.0|
C-Cell, Hyperplasia, Focal | 2 | 1 2.0|
Follicle, Cyst, Multiple | 1 | 1 1.0|
Follicular Cell, Hyperplasia, Diffuse| 4 | 1 4.0|
Follicular Cell, Hyperplasia, Focal | 2 | 1 2.0|
Follicular Cell, Hyperplasia, | | |
Multifocal | 1 3 3 | 7 2.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + +| 2 |
Atrophy | 4 | 1 4.0|
Cyst, Multiple | 3| 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | 4 3 4 4 4 | 8 3.8|
Thrombosis | | 1 3.0|
Interstitium, Hyperplasia | 2 | 1 2.0|
Periovarian Tissue, Infiltration | | |
Cellular, Lymphocyte | 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenomyosis | 2 | 1 2.0|
Amyloid Deposition | 2 | 1 2.0|
Angiectasis, Multifocal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 6| 6| 3| |
DAY ON TEST | 9| 3| 3| 3| 4| 3| 4| 2| 3| 3| 5| 0| 3| 1| 2| 2| 2| 1| 0| 2| 1| 2| 0| 2| 8| |
| 0| 0| 1| 1| 2| 1| 2| 9| 1| 1| 5| 4| 1| 9| 9| 9| 9| 3| 5| 9| 9| 9| 3| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia, Cystic | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 1 1.0|
Thrombosis | | 1 1.0|
Bilateral, Hyperplasia, Cystic | 2 3 3 3 1 2 1 2 2 2 3 1 3 4 2| 33 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Lymphoid | 3 2 | 2 2.5|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Renal, Hemorrhage, Subacute | | 1 2.0|
Renal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
Hemorrhage, Subacute | | 1 1.0|
Hyperplasia, Lymphoid | 2 2 3 4 | 6 2.7|
Hyperplasia | | 1 3.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + M M + + + + + M + A +| 41 |
Angiectasis | | 1 3.0|
Depletion Lymphoid | | 1 4.0|
Hematopoietic Cell Proliferation | 2 3 3 | 4 2.5|
Hemorrhage, Acute | 2 4 3 2 4 | 10 2.4|
Hemorrhage, Subacute | 2 | 2 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Edema | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 2 2 2 2 4 | 10 2.7|
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Infarct | 3 | 1 3.0|
Pigmentation, Hemosiderin | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis, Focal | 2 | 1 2.0|
Depletion Lymphoid | 3 3 3 | 4 3.0|
Ectopic Parathyroid Gland | X X | 3 1.0|
Hyperplasia, Lymphoid | 1 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 6| 6| 3| |
DAY ON TEST | 9| 3| 3| 3| 4| 3| 4| 2| 3| 3| 5| 0| 3| 1| 2| 2| 2| 1| 0| 2| 1| 2| 0| 2| 8| |
| 0| 0| 1| 1| 2| 1| 2| 9| 1| 1| 5| 4| 1| 9| 9| 9| 9| 3| 5| 9| 9| 9| 3| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Ectasia, Multifocal | 2 3 2 2 1 | 8 2.3|
Hyperplasia, Diffuse | 2 3 3 | 7 2.3|
Inflammation, Chronic Active, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active, Focal | | 1 2.0|
Inflammation, Chronic Active, | | |
Multifocal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrous Osteodystrophy | 3 2 2 1 | 13 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
Inflammation, Chronic, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Compression | X X X X X X | 9 |
Hemorrhage, Multifocal | 2 | 1 2.0|
Hydrocephalus | 3 | 2 2.5|
Mineralization, Multifocal | 1 3 2 2 2 1 2 1 2 2 1 2 1 2 | 26 2.0|
Perivascular, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 2 1| 2 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + M| 46 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 2 1.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2 2 2 2 4 2 2| 16 1.8|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 2 1.5|
Alveolus, Infiltration Cellular, | | |
Diffuse, Histiocyte | 3 | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 6| 7| 6| 7| 6| 6| 3| |
DAY ON TEST | 9| 3| 3| 3| 4| 3| 4| 2| 3| 3| 5| 0| 3| 1| 2| 2| 2| 1| 0| 2| 1| 2| 0| 2| 8| |
| 0| 0| 1| 1| 2| 1| 2| 9| 1| 1| 5| 4| 1| 9| 9| 9| 9| 3| 5| 9| 9| 9| 3| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lumen, Exudate | 1 1 | 3 1.0|
Mucosa, Inflammation, Chronic | 2 | 2 2.0|
Mucosa, Inflammation, Chronic Active | 2 1 1 1 4 1 | 9 1.6|
Mucosa, Ulcer | 1 | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 2 | 1 2.0|
Olfactory Epithelium, Atrophy | 2 | 2 1.5|
Respiratory Epithelium, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 3 | 2 2.5|
Inflammation, Chronic Active | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cytoplasmic Alteration, Multifocal | | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 2 3 1 2 1 4 2 1 3 1 1 4| 20 1.9|
Inflammation, Acute, Multifocal | 3 | 1 3.0|
Metaplasia, Focal, Osseous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 1 | 3 1.7|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 2 1 1 1 1 2 1 2 1 1 | 18 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 4| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 8| 2| 2| 2| 2| 1| 2| 0| 2| 2| 0| 8| 1| 2| 3| 6| 3| 4| 0| 3| 3|
| 9| 5| 9| 9| 6| 9| 9| 1| 9| 4| 9| 3| 9| 9| 3| 1| 2| 9| 0| 1| 0| 6| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Gallbladder | M A M + A + + A + + + + + + M A A + + M + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + A + + + + + + + + + + + A + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + A + M + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + M + A + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + A + M + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + A + + + + + + + + A + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Granuloma, Multifocal | |
Hematopoietic Cell Proliferation, | |
Multifocal | 1 1 1 1 3 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 2 1 2 |
Necrosis, Acute, Multifocal | 3 |
Bile Duct, Hyperplasia, Multifocal | 2 |
Centrilobular, Fatty Change, Diffuse | |
Centrilobular, Necrosis, Acute, | |
Diffuse | |
Right Lateral Lobe, | |
Hepatodiaphragmatic Nodule | 1 |
Vein, Thrombosis | |
__________________________________________________________________________|
Mesentery | + + |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Multiple | 4 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 2 |
Acinus, Atrophy, Diffuse | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 2 2 1 1 2 1 1 1 1 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 4| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 8| 2| 2| 2| 2| 1| 2| 0| 2| 2| 0| 8| 1| 2| 3| 6| 3| 4| 0| 3| 3|
| 9| 5| 9| 9| 6| 9| 9| 1| 9| 4| 9| 3| 9| 9| 3| 1| 2| 9| 0| 1| 0| 6| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 2 |
Artery, Mineralization, Multifocal | 4 |
Atrium Left, Thrombosis | |
Epicardium, Inflammation, Chronic, | |
Focal | |
Epicardium, Inflammation, Chronic | |
Active, Focal | |
Epicardium, Inflammation, Suppurative| 2 |
Valve, Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Accessory Adrenal Cortical | |
Nodule | |
Capsule, Inflammation, Chronic | |
Active, Suppurative | 4 |
Subcapsular, Hyperplasia, Diffuse | 3 4 |
Subcapsular, Hyperplasia, Focal | 2 |
Subcapsular, Hyperplasia, Multifocal | 3 2 3 2 2 3 2 2 3 2 3 2 2 3 3 2 3 2 2 2 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 4 |
Hyperplasia, Multifocal | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + M + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + M + + +|
Congestion | 3 |
Cyst | |
Pars Distalis, Angiectasis | 3 3 |
Pars Distalis, Hyperplasia, Focal | 2 1 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation, Chronic, Focal | |
Inflammation, Chronic, Multifocal | 2 |
Inflammation, Chronic Active, Focal | 2 |
Follicle, Cyst, Multiple | 1 |
Follicular Cell, Hyperplasia, Focal | 2 2 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 4| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 8| 2| 2| 2| 2| 1| 2| 0| 2| 2| 0| 8| 1| 2| 3| 6| 3| 4| 0| 3| 3|
| 9| 5| 9| 9| 6| 9| 9| 1| 9| 4| 9| 3| 9| 9| 3| 1| 2| 9| 0| 1| 0| 6| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia, | |
Multifocal | 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Cyst | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Angiectasis, Focal | |
Cyst | 2 3 2 2 |
Metaplasia, Focal, Osseous | |
Pigmentation | |
Periovarian Tissue, Infiltration | |
Cellular, Lymphocyte | 3 |
Periovarian Tissue, Inflammation, | |
Chronic Active | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Abscess, Multiple | 4 |
Cyst | 2 3 |
Dilatation | 4 |
Hyperplasia, Cystic | 3 |
Inflammation, Chronic Active | |
Thrombosis, Multiple | |
Bilateral, Hyperplasia, Cystic | 3 2 3 1 3 2 3 1 3 1 3 4 1 1 3 4|
Epithelium, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 3 |
Myeloid Cell, Hyperplasia | 2 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 3 |
Lumbar, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | 3 2 2 |
Mediastinal, Hyperplasia | |
Pancreatic, Hemorrhage, Acute | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + M M M + + + + +|
Hemorrhage, Subacute | 2 |
Hyperplasia, Lymphoid | 2 2 3 3 2 2 4|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 4| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 8| 2| 2| 2| 2| 1| 2| 0| 2| 2| 0| 8| 1| 2| 3| 6| 3| 4| 0| 3| 3|
| 9| 5| 9| 9| 6| 9| 9| 1| 9| 4| 9| 3| 9| 9| 3| 1| 2| 9| 0| 1| 0| 6| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Re Cell | |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Subacute | 2 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + M + M + + M + M + + M + + + + +|
Hematopoietic Cell Proliferation | 2 3 |
Hemorrhage, Acute | 3 2 2 3 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia, Focal | 4 |
Hematopoietic Cell Proliferation | 3 2 3 3 3 2 |
Hyperplasia, Lymphoid | 2 2 2|
Capsule, Inflammation, Chronic Active| 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + M + + M + M + + + + + M M + +|
Depletion Lymphoid | 3 4 3 |
Ectopic Parathyroid Gland | |
Hyperplasia, Lymphoid | 1 1 |
Metaplasia, Focal, Osseous | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + M + + + + +|
Ectasia, Multifocal | |
Hyperplasia, Diffuse | 4 2 4 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 X 1 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Compression | X X X |
Hydrocephalus | |
Mineralization, Multifocal | 2 2 1 2 1 3 2 1 2 1|
Meninges, Infiltration Cellular, | |
Multifocal, Lymphocyte | |
Perivascular, Infiltration Cellular, | |
Multifocal, Lymphocyte | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 2 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 4| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 8| 2| 2| 2| 2| 1| 2| 0| 2| 2| 0| 8| 1| 2| 3| 6| 3| 4| 0| 3| 3|
| 9| 5| 9| 9| 6| 9| 9| 1| 9| 4| 9| 3| 9| 9| 3| 1| 2| 9| 0| 1| 0| 6| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Mineralization | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus Tumor, Multiple | X |
Hemorrhage, Acute, Focal | 3 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 3 2 4 4 2 2 4 2 4 4 4 4 3 2 2 2|
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 3 4 4 4 3 2 4 4 4 3 3 2 |
Bronchiole, Hyperplasia, Multifocal | 3 2 4 4 2 2 3 4 2 4 4 4 2 4 3 1 2 2 2|
Mediastinum, Infiltration Cellular, | |
Multifocal, Lymphocyte | 3 |
Mediastinum, Inflammation, Chronic | 3 |
Pleura, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 1 3 1 1 2 1 2 2 1 2 2 2 3 1 2|
Mucosa, Inflammation, Chronic Active | 2 2 2 1 4 1 4 1 2 1 1|
Olfactory Epithelium, Atrophy | 2 3 |
Respiratory Epithelium, Hyperplasia | 1 2 1 2 1 3 1 2 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 2 3 1 |
Sinus, Hyperplasia | 3 |
Sinus, Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 2 2 1 1 1 2 1 |
Metaplasia, Focal, Osseous | 3 |
Pigmentation, Diffuse | |
Cortex, Mineralization, Multifocal | 3 |
Interstitial Tissue, Inflammation, | |
Chronic, Multifocal | |
Renal Tubule, Hyperplasia, Focal | 2 |
Renal Tubule, Necrosis, Acute, | |
Multifocal | 2 |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M + M + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 4| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 2| 8| 2| 2| 2| 2| 1| 2| 0| 2| 2| 0| 8| 1| 2| 3| 6| 3| 4| 0| 3| 3|
| 9| 5| 9| 9| 6| 9| 9| 1| 9| 4| 9| 3| 9| 9| 3| 1| 2| 9| 0| 1| 0| 6| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 2 1 1 1 |
Artery, Inflammation, Chronic Active,| |
Multifocal | 4|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 5| 6| 6| 7| 6| 7| 5| 7| |
DAY ON TEST | 3| 2| 9| 3| 4| 2| 4| 3| 6| 3| 9| 7| 3| 3| 8| 3| 3| 6| 3| 8| 3| 7| 3| 4| 0| |
| 0| 0| 8| 0| 4| 6| 5| 0| 6| 0| 8| 4| 0| 0| 4| 0| 0| 5| 3| 7| 0| 3| 0| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + + + + + + + + + + + + A +| 36 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + M + + + + + + + + + + + + + + + + + + + +| 45 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + + + + + A +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + A +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Granuloma, Multifocal | 4 | 1 4.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 1 | 7 1.3|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2 | 6 1.5|
Necrosis, Acute, Multifocal | 2 2 | 3 2.3|
Bile Duct, Hyperplasia, Multifocal | | 1 2.0|
Centrilobular, Fatty Change, Diffuse | 3 | 1 3.0|
Centrilobular, Necrosis, Acute, | | |
Diffuse | 2 | 1 2.0|
Right Lateral Lobe, | | |
Hepatodiaphragmatic Nodule | | 1 1.0|
Vein, Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 5 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess, Multiple | | 1 4.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 2 1 | 7 1.3|
Acinus, Atrophy, Diffuse | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 5| 6| 6| 7| 6| 7| 5| 7| |
DAY ON TEST | 3| 2| 9| 3| 4| 2| 4| 3| 6| 3| 9| 7| 3| 3| 8| 3| 3| 6| 3| 8| 3| 7| 3| 4| 0| |
| 0| 0| 8| 0| 4| 6| 5| 0| 6| 0| 8| 4| 0| 0| 4| 0| 0| 5| 3| 7| 0| 3| 0| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Lymphocyte | 3 1 1 2 1 2 1 2 | 19 1.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tooth | + | 2 |
Developmental Malformation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation | | 1 2.0|
Artery, Mineralization, Multifocal | | 1 4.0|
Atrium Left, Thrombosis | 4 | 1 4.0|
Epicardium, Inflammation, Chronic, | | |
Focal | 2 | 1 2.0|
Epicardium, Inflammation, Chronic | | |
Active, Focal | 4 | 1 4.0|
Epicardium, Inflammation, Suppurative| | 1 2.0|
Valve, Pigmentation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Accessory Adrenal Cortical | | |
Nodule | X | 1 |
Capsule, Inflammation, Chronic | | |
Active, Suppurative | | 1 4.0|
Subcapsular, Hyperplasia, Diffuse | 2 4 | 4 3.3|
Subcapsular, Hyperplasia, Focal | | 1 2.0|
Subcapsular, Hyperplasia, Multifocal | 3 2 2 2 2 3 2 3 2 2 3 2 1 2 2 2 2 3 2 3 3 2| 43 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Acute | 3 | 1 3.0|
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + M + M + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Focal | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 2 3 | 3 3.0|
Hyperplasia, Multifocal | 2 | 3 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + M + + + + M + M + + M + + + + + + +| 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Congestion | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 5| 6| 6| 7| 6| 7| 5| 7| |
DAY ON TEST | 3| 2| 9| 3| 4| 2| 4| 3| 6| 3| 9| 7| 3| 3| 8| 3| 3| 6| 3| 8| 3| 7| 3| 4| 0| |
| 0| 0| 8| 0| 4| 6| 5| 0| 6| 0| 8| 4| 0| 0| 4| 0| 0| 5| 3| 7| 0| 3| 0| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cyst | 4 | 1 4.0|
Pars Distalis, Angiectasis | 2 | 3 2.7|
Pars Distalis, Hyperplasia, Focal | 2 | 4 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Inflammation, Chronic, Focal | 1 1 | 2 1.0|
Inflammation, Chronic, Multifocal | 2 | 2 2.0|
Inflammation, Chronic Active, Focal | | 1 2.0|
Follicle, Cyst, Multiple | 1 1 | 3 1.0|
Follicular Cell, Hyperplasia, Focal | | 2 2.0|
Follicular Cell, Hyperplasia, | | |
Multifocal | 3 2 1 | 5 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 | 1 4.0|
Angiectasis, Focal | 4| 1 4.0|
Cyst | 3 4 4 4 4| 9 3.1|
Metaplasia, Focal, Osseous | 2 | 1 2.0|
Pigmentation | 2 | 1 2.0|
Periovarian Tissue, Infiltration | | |
Cellular, Lymphocyte | 3 | 2 3.0|
Periovarian Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 | 1 4.0|
Abscess, Multiple | | 1 4.0|
Cyst | 3 | 3 2.7|
Dilatation | | 1 4.0|
Hyperplasia, Cystic | 2 4 | 3 3.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Thrombosis, Multiple | 3 | 1 3.0|
Bilateral, Hyperplasia, Cystic | 1 1 4 2 1 1 2 1 4 2 2 2 1 2 3 2 2 2 2| 35 2.1|
Epithelium, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 5| 6| 6| 7| 6| 7| 5| 7| |
DAY ON TEST | 3| 2| 9| 3| 4| 2| 4| 3| 6| 3| 9| 7| 3| 3| 8| 3| 3| 6| 3| 8| 3| 7| 3| 4| 0| |
| 0| 0| 8| 0| 4| 6| 5| 0| 6| 0| 8| 4| 0| 0| 4| 0| 0| 5| 3| 7| 0| 3| 0| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | | 1 3.0|
Myeloid Cell, Hyperplasia | 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Acute | | 1 3.0|
Lumbar, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | 3 | 4 2.5|
Mediastinal, Hyperplasia | 2 | 1 2.0|
Pancreatic, Hemorrhage, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + +| 45 |
Hemorrhage, Subacute | | 1 2.0|
Hyperplasia, Lymphoid | | 7 2.6|
Hyperplasia | 2 | 1 2.0|
Hyperplasia, Re Cell | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Inflammation, Subacute | | 1 2.0|
Pigmentation, Hemosiderin | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + + + M M + + + + + + + M + M + + M| 37 |
Hematopoietic Cell Proliferation | 3 3 3 | 5 2.8|
Hemorrhage, Acute | 2 1 2 2 | 9 2.2|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia, Focal | | 1 4.0|
Hematopoietic Cell Proliferation | 2 2 4 4 2 3 3 2 | 14 2.7|
Hyperplasia, Lymphoid | 4 2| 5 2.4|
Capsule, Inflammation, Chronic Active| | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + M + M + + M + + M + + + + M + M M M A M M + + +| 32 |
Depletion Lymphoid | 4 3 3| 6 3.3|
Ectopic Parathyroid Gland | X X | 2 |
Hyperplasia, Lymphoid | 2 2 | 4 1.5|
Metaplasia, Focal, Osseous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + M + + +| 45 |
Ectasia, Multifocal | 3 2 | 2 2.5|
Hyperplasia, Diffuse | 1 | 6 2.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 5| 6| 6| 7| 6| 7| 5| 7| |
DAY ON TEST | 3| 2| 9| 3| 4| 2| 4| 3| 6| 3| 9| 7| 3| 3| 8| 3| 3| 6| 3| 8| 3| 7| 3| 4| 0| |
| 0| 0| 8| 0| 4| 6| 5| 0| 6| 0| 8| 4| 0| 0| 4| 0| 0| 5| 3| 7| 0| 3| 0| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 1 1 1 2| 10 1.4|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | | 1 4.0|
Compression | X X X X X | 8 |
Hydrocephalus | 2 | 1 2.0|
Mineralization, Multifocal | 1 1 2 3 1 1 3 1 1 1| 20 1.6|
Meninges, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 1 | 1 1.0|
Perivascular, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 2 2 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + M + + + + + + +| 47 |
Exudate | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Embolus Tumor, Multiple | | 1 |
Hemorrhage, Acute, Focal | | 1 3.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 2 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 4 2 3 4 1 4 3 4 4 2 3 2 2 3 4 3 3 4 3 3 4 2 3 2 4| 41 3.0|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 2 2 4 3 3 4 4 3 3 2 3 3 3 2 2 2 4 4 3 3| 32 3.1|
Bronchiole, Hyperplasia, Multifocal | 4 2 3 4 1 4 4 4 3 2 2 3 4 3 3 4 3 3 4 3 2 4| 41 3.0|
Mediastinum, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 2 | 2 2.5|
Mediastinum, Inflammation, Chronic | | 1 3.0|
Pleura, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Exudate | 1 2 1 1 1 3 1 2 1 3 1 1 2 2 2 2 3 2| 33 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 4| 7| 6| 7| 6| 7| 6| 6| 7| 7| 6| 7| 7| 5| 6| 6| 7| 6| 7| 5| 7| |
DAY ON TEST | 3| 2| 9| 3| 4| 2| 4| 3| 6| 3| 9| 7| 3| 3| 8| 3| 3| 6| 3| 8| 3| 7| 3| 4| 0| |
| 0| 0| 8| 0| 4| 6| 5| 0| 6| 0| 8| 4| 0| 0| 4| 0| 0| 5| 3| 7| 0| 3| 0| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mucosa, Inflammation, Chronic Active | 2 1 4 2 1 1 4 2 2 2 1 1 | 23 1.9|
Olfactory Epithelium, Atrophy | | 2 2.5|
Respiratory Epithelium, Hyperplasia | 1 3 2 1 1 1 1 2 | 17 1.6|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 3 2 1 2 | 8 1.9|
Sinus, Hyperplasia | | 1 3.0|
Sinus, Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 2 1 1 1 2 2 | 15 1.4|
Metaplasia, Focal, Osseous | | 1 3.0|
Pigmentation, Diffuse | 3 | 1 3.0|
Cortex, Mineralization, Multifocal | | 1 3.0|
Interstitial Tissue, Inflammation, | | |
Chronic, Multifocal | 1 2 | 2 1.5|
Renal Tubule, Hyperplasia, Focal | | 1 2.0|
Renal Tubule, Necrosis, Acute, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Ureter | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 3 1 1 1 2 1 3 2 1 2 2 | 17 1.5|
Artery, Inflammation, Chronic Active,| | |
Multifocal | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 1| 3| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 1| 2| 3| 6| 9| 0| 3| 3| 3| 3| 6| 0| 3| 0| 3| 1| 7| 3| 3| 3| 3|
| 0| 0| 0| 1| 6| 8| 5| 6| 3| 3| 0| 0| 0| 0| 5| 1| 1| 6| 1| 8| 6| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + M A + + + + + A + + + + + + + M + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A M + A + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + M + + + + A + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + M A + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + A + M + M + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + A + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly | |
Fatty Change, Focal | 3 |
Hematopoietic Cell Proliferation, | |
Multifocal | 1 1 1 1 |
Infiltration Cellular, Focal, | |
Lymphocyte | 2|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 |
Inflammation, Acute, Multifocal | |
Inflammation, Multifocal, Subacute | 1 1|
Necrosis, Acute, Multifocal | |
Necrosis, Chronic, Multifocal | |
Necrosis, Focal, Subacute | 2 |
Vacuolization Cytoplasmic, Multifocal| 2 |
Periportal, Vacuolization | |
Cytoplasmic, Diffuse | |
Portal, Inflammation, Chronic, | |
Multifocal | 1 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 2 2 1 |
Acinus, Atrophy, Diffuse | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 1| 3| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 1| 2| 3| 6| 9| 0| 3| 3| 3| 3| 6| 0| 3| 0| 3| 1| 7| 3| 3| 3| 3|
| 0| 0| 0| 1| 6| 8| 5| 6| 3| 3| 0| 0| 0| 0| 5| 1| 1| 6| 1| 8| 6| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Lymphocyte | 2 1 1 1 1 1 2 1 2 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Epithelium, Hyperplasia, Diffuse | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
Necrosis, Acute, Multifocal | |
Mucosa, Degeneration, Multifocal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Inflammation, Chronic Active, | |
Focal | 3 |
Artery, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
Inflammation, Chronic, Multifocal | |
Mineralization, Multifocal | |
Necrosis, Acute, Focal | |
Atrium Left, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Accessory Adrenal Cortical | |
Nodule | |
Subcapsular, Hyperplasia, Diffuse | 3 2 |
Subcapsular, Hyperplasia, Multifocal | 2 2 2 2 2 1 2 2 2 3 2 3 2 2 3 3 3 2 2 2 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + M + + + + + + +|
Cyst | |
Hyperplasia, Focal | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 4 2 |
Hyperplasia, Multifocal | |
Hypoplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + + + + M + M + + M + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + A + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 2 4|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 1| 3| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 1| 2| 3| 6| 9| 0| 3| 3| 3| 3| 6| 0| 3| 0| 3| 1| 7| 3| 3| 3| 3|
| 0| 0| 0| 1| 6| 8| 5| 6| 3| 3| 0| 0| 0| 0| 5| 1| 1| 6| 1| 8| 6| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia, Focal | 1 2 |
Pars Distalis, Hyperplasia, | |
Multifocal | 2 |
Pars Distalis, Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Acute, Focal | 2|
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic, Multifocal | |
Inflammation, Chronic Active, Focal | 1 |
Inflammation, Chronic Active, | |
Multifocal | 1 2 |
Follicle, Cyst | |
Follicle, Cyst, Multiple | |
Follicular Cell, Hyperplasia, Focal | 3 |
Follicular Cell, Hyperplasia, | |
Multifocal | 1 2 3 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Cyst, Multiple | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +|
Cyst | 2 3 4 2 |
Mineralization | 3 |
Pigmentation | 4 |
Periovarian Tissue, Infiltration | |
Cellular, Lymphocyte | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Dilatation | 4 4 |
Hyperplasia, Atypical, Focal, | |
Glandular | 3 |
Hyperplasia, Cystic | 3 3 |
Bilateral, Hyperplasia, Cystic | 2 2 3 2 2 2 4 3 2 3 2 2 1 4 1 2 3 4 1 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 1| 3| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 1| 2| 3| 6| 9| 0| 3| 3| 3| 3| 6| 0| 3| 0| 3| 1| 7| 3| 3| 3| 3|
| 0| 0| 0| 1| 6| 8| 5| 6| 3| 3| 0| 0| 0| 0| 5| 1| 1| 6| 1| 8| 6| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy, Diffuse | 3 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | 2 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | 4 |
Renal, Hematopoietic Cell | |
Proliferation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + M + M M + +|
Cyst | 2 3 |
Hemorrhage, Acute | 2 |
Hyperplasia, Lymphoid | 2 1 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + M M M M + M + + + M M + + M + M + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage, Acute | 3 2 |
Hemorrhage, Subacute | |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 2 3 2 2 |
Hyperplasia, Lymphoid | 2 2 3 |
Pigmentation, Hemosiderin | |
Capsule, Ectopic Tissue | X |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + M +|
Depletion Lymphoid | 3 3 |
Ectopic Parathyroid Gland | X |
Hyperplasia, Lymphoid | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + M M + + + + + + + + + + + + + + +|
Ectasia, Multifocal | 2 |
Hyperplasia, Diffuse | 2 |
__________________________________________________________________________|
Skin | + + + + + A + + + + + + + + + + + + + + + + + + +|
Hair Follicle, Inflammation, Chronic | |
Active | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 1 2|
Osteoporosis, Focal | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 1| 3| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 1| 2| 3| 6| 9| 0| 3| 3| 3| 3| 6| 0| 3| 0| 3| 1| 7| 3| 3| 3| 3|
| 0| 0| 0| 1| 6| 8| 5| 6| 3| 3| 0| 0| 0| 0| 5| 1| 1| 6| 1| 8| 6| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Mineralization, Multifocal | 2 2 2 2 1 1 1 1 2 3 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + M + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute, Multifocal | |
Hemorrhage, Multifocal, Subacute | 4 |
Infiltration Cellular, Diffuse, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
Inflammation, Acute, Focal | 2 |
Pigmentation, Diffuse, Hemosiderin | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 4 3 1 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 4 1|
Alveolus, Infiltration Cellular, | |
Diffuse, Histiocyte | 2 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 2 4 2 |
Bronchiole, Hyperplasia, Focal | |
Bronchiole, Hyperplasia, Multifocal | 1 1|
Interstitium, Inflammation, Chronic | |
Active, Focal | |
Pleura, Infiltration Cellular, | |
Lymphocyte | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 3 2 1 3 2 1 1 2 1 1 1 2 2 |
Lumen, Foreign Body | |
Mucosa, Inflammation, Chronic | 2 |
Mucosa, Inflammation, Chronic Active | 1 |
Mucosa, Ulcer | |
Nasolacrimal Duct, Exudate | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 |
Olfactory Epithelium, Atrophy | 1 1 |
Respiratory Epithelium, Hyperplasia | 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 1| 3| 6| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 1| 2| 3| 6| 9| 0| 3| 3| 3| 3| 6| 0| 3| 0| 3| 1| 7| 3| 3| 3| 3|
| 0| 0| 0| 1| 6| 8| 5| 6| 3| 3| 0| 0| 0| 0| 5| 1| 1| 6| 1| 8| 6| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0.5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Abscess | 4 |
Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 |
Infiltration Cellular, Lymphocyte | 2 1 1 1 1|
Nephropathy, Chronic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 2 3 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 3| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| |
DAY ON TEST | 2| 3| 3| 3| 3| 9| 3| 3| 3| 9| 1| 8| 1| 9| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 6| |
| 4| 1| 1| 1| 2| 9| 2| 1| 2| 2| 5| 9| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + A + + + + + + + + + M + M +| 40 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A M + + + + + + + + M + + + +| 44 |
Peyer's Patch, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + M M + + + + + + + + + + + M +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytomegaly | 3 | 1 3.0|
Fatty Change, Focal | | 1 3.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 1 1 1 1 1 1 | 10 1.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 2 1.0|
Inflammation, Acute, Multifocal | 1 | 1 1.0|
Inflammation, Multifocal, Subacute | 1 | 3 1.0|
Necrosis, Acute, Multifocal | 4 3 2 3| 4 3.0|
Necrosis, Chronic, Multifocal | 4 | 1 4.0|
Necrosis, Focal, Subacute | 1 | 2 1.5|
Vacuolization Cytoplasmic, Multifocal| | 1 2.0|
Periportal, Vacuolization | | |
Cytoplasmic, Diffuse | 3 | 1 3.0|
Portal, Inflammation, Chronic, | | |
Multifocal | 1 | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 4.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 1 2 2 1 | 9 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 3| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| |
DAY ON TEST | 2| 3| 3| 3| 3| 9| 3| 3| 3| 9| 1| 8| 1| 9| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 6| |
| 4| 1| 1| 1| 2| 9| 2| 1| 2| 2| 5| 9| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinus, Atrophy, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 2 2 2 1 1 | 17 1.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 1 | 1 1.0|
Epithelium, Hyperplasia, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 1.0|
Necrosis, Acute, Multifocal | 3| 1 3.0|
Mucosa, Degeneration, Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
Aorta, Inflammation, Chronic Active, | | |
Focal | | 1 3.0|
Artery, Inflammation, Chronic, | | |
Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 1.0|
Inflammation, Chronic, Multifocal | 2| 1 2.0|
Mineralization, Multifocal | 2| 1 2.0|
Necrosis, Acute, Focal | 3| 1 3.0|
Atrium Left, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Accessory Adrenal Cortical | | |
Nodule | X X | 2 |
Subcapsular, Hyperplasia, Diffuse | 3 2 | 4 2.5|
Subcapsular, Hyperplasia, Multifocal | 2 3 3 2 1 3 4 2 3 3 2 2 2 2 3 2 2 3 2 3 3 1| 43 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 3| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| |
DAY ON TEST | 2| 3| 3| 3| 3| 9| 3| 3| 3| 9| 1| 8| 1| 9| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 6| |
| 4| 1| 1| 1| 2| 9| 2| 1| 2| 2| 5| 9| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cyst | 3 | 1 3.0|
Hyperplasia, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | M + + + + M + + + + + + + + M + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 3 3.0|
Hyperplasia, Multifocal | 2 2 | 2 2.0|
Hypoplasia | | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + M + + + + + M + + + M + + + + + M| 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | 4 4 4 | 7 3.3|
Pars Distalis, Hyperplasia, Focal | 3 2 | 4 2.0|
Pars Distalis, Hyperplasia, | | |
Multifocal | 2 | 2 2.0|
Pars Distalis, Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 4 | 2 3.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 2 1.5|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 3 | 1 3.0|
Inflammation, Acute, Focal | | 1 2.0|
Inflammation, Chronic, Focal | | 1 1.0|
Inflammation, Chronic, Multifocal | 2 2 | 2 2.0|
Inflammation, Chronic Active, Focal | 1 | 2 1.0|
Inflammation, Chronic Active, | | |
Multifocal | | 2 1.5|
Follicle, Cyst | 2 | 1 2.0|
Follicle, Cyst, Multiple | 2 1 | 2 1.5|
Follicular Cell, Hyperplasia, Focal | 2 3 | 3 2.7|
Follicular Cell, Hyperplasia, | | |
Multifocal | 2 1 3 3 4 | 9 2.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
Cyst, Multiple | 4 | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 3| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| |
DAY ON TEST | 2| 3| 3| 3| 3| 9| 3| 3| 3| 9| 1| 8| 1| 9| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 6| |
| 4| 1| 1| 1| 2| 9| 2| 1| 2| 2| 5| 9| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | 4 4 4 4 | 8 3.4|
Mineralization | | 1 3.0|
Pigmentation | | 1 4.0|
Periovarian Tissue, Infiltration | | |
Cellular, Lymphocyte | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
Dilatation | | 2 4.0|
Hyperplasia, Atypical, Focal, | | |
Glandular | | 1 3.0|
Hyperplasia, Cystic | 3 | 3 3.0|
Bilateral, Hyperplasia, Cystic | 3 2 2 2 4 1 3 3 1 2 2 2 2 1 2 2 3 2 3 3 | 40 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Diffuse | | 1 3.0|
Myeloid Cell, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Lymphoid | 3 | 3 2.3|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Hyperplasia | | 1 4.0|
Renal, Hematopoietic Cell | | |
Proliferation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + M M + + + +| 43 |
Cyst | 3 | 3 2.7|
Hemorrhage, Acute | 3 | 2 2.5|
Hyperplasia, Lymphoid | 3 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + M + + M M + + + +| 36 |
Depletion Lymphoid | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 3 2 | 4 2.3|
Hemorrhage, Acute | 2 1 | 4 2.0|
Hemorrhage, Subacute | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 4 4 3| 9 3.0|
Hyperplasia, Lymphoid | 2 3 | 5 2.4|
Pigmentation, Hemosiderin | 3 1 | 2 2.0|
Capsule, Ectopic Tissue | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + + + + + M + + + M +| 44 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 3| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| |
DAY ON TEST | 2| 3| 3| 3| 3| 9| 3| 3| 3| 9| 1| 8| 1| 9| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 6| |
| 4| 1| 1| 1| 2| 9| 2| 1| 2| 2| 5| 9| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Depletion Lymphoid | 3 2 3 3 | 6 2.8|
Ectopic Parathyroid Gland | | 1 |
Hyperplasia, Lymphoid | 2 3 | 6 2.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Ectasia, Multifocal | 2 3 2 | 4 2.3|
Hyperplasia, Diffuse | 3 2 3 1 2 2 2 | 8 2.1|
__________________________________________________________________________|____________|
Skin | + M + + + + + + + + + + + + + + + + + + + M M + +| 46 |
Hair Follicle, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 3 2 2 2 3 | 10 2.0|
Osteoporosis, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X | 2 |
Mineralization, Multifocal | 2 3 1 2 2 2 2 1 3 2 2 2 2 1 2 | 26 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + M + + + + + + + + + + M +| 45 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Acute, Multifocal | 4| 1 4.0|
Hemorrhage, Multifocal, Subacute | | 1 4.0|
Infiltration Cellular, Diffuse, | | |
Lymphocyte | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 2 1.5|
Inflammation, Acute, Focal | | 1 2.0|
Pigmentation, Diffuse, Hemosiderin | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 3 1 2 2 2 4 | 13 2.3|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 3 4 2 2 4 | 7 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 3| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| |
DAY ON TEST | 2| 3| 3| 3| 3| 9| 3| 3| 3| 9| 1| 8| 1| 9| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 6| |
| 4| 1| 1| 1| 2| 9| 2| 1| 2| 2| 5| 9| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Infiltration Cellular, | | |
Diffuse, Histiocyte | 2 | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 2 3 1 1 4 | 8 2.4|
Bronchiole, Hyperplasia, Focal | 2 3 | 2 2.5|
Bronchiole, Hyperplasia, Multifocal | 3 4 4 | 5 2.6|
Interstitium, Inflammation, Chronic | | |
Active, Focal | 2 | 1 2.0|
Pleura, Infiltration Cellular, | | |
Lymphocyte | 3 | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Exudate | 2 2 1 3 1 1 1 1 2 2 1 1 1 2 2 2 1 | 30 1.6|
Lumen, Foreign Body | 1 | 1 1.0|
Mucosa, Inflammation, Chronic | | 1 2.0|
Mucosa, Inflammation, Chronic Active | 1 2 1 1 1 1 2 1 2 | 10 1.3|
Mucosa, Ulcer | 2 2 | 2 2.0|
Nasolacrimal Duct, Exudate | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 2.0|
Olfactory Epithelium, Atrophy | 2 1 | 4 1.3|
Respiratory Epithelium, Hyperplasia | 1 1 2 2 | 5 1.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 3 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 2 1.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Abscess | | 1 4.0|
Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 1 4| 3 2.0|
Infiltration Cellular, Lymphocyte | 1 1 2 2 2 2 1 2 1 | 14 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 3| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 2| |
DAY ON TEST | 2| 3| 3| 3| 3| 9| 3| 3| 3| 9| 1| 8| 1| 9| 3| 3| 9| 3| 3| 3| 3| 3| 3| 0| 6| |
| 4| 1| 1| 1| 2| 9| 2| 1| 2| 2| 5| 9| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 1| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
0.5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy, Chronic | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 1 1 2 1 2 1 | 17 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 2| 2| 6| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| 3|
| 9| 7| 9| 9| 2| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 9| 0| 1| 0| 0| 9| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + + + + M M + + + + + + M + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 3 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage, Acute | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + M + M + + + M + + M + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + A + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage, Acute | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Basophilic Focus, Multiple | X |
Cytomegaly, Multifocal | |
Eosinophilic Focus | |
Fatty Change, Focal | |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Multifocal, Nodular | |
Infarct | 4 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Inflammation, Chronic, Multifocal | |
Inflammation, Multifocal, Subacute | 2 |
Mixed Cell Focus | |
Necrosis, Acute, Multifocal | 4 |
Bile Duct, Hyperplasia, Multifocal | 1 2 |
Centrilobular, Fatty Change, | |
Multifocal | 2 |
Centrilobular, Necrosis, Diffuse | |
Oval Cell, Hyperplasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Duct, Cyst | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 1 1 1 2 2 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 2| 2| 6| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| 3|
| 9| 7| 9| 9| 2| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 9| 0| 1| 0| 0| 9| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Focal | |
Ulcer | |
Epithelium, Hyperplasia, Diffuse | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +|
Mucosa, Mineralization | |
__________________________________________________________________________|
Tooth | + |
Dysplasia | |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Artery, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia, Focal | 2 4|
Subcapsular, Hyperplasia, Multifocal | 2 1 2 1 2 1 2 1 2 1 3 2 1 1 2 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Focal | 3 3 |
Hyperplasia, Multifocal | 4 |
Hypertrophy, Focal | 2 2 |
Hypertrophy, Multifocal | 2 3 2 3|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + M + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hyperplasia, Multifocal | 2 2 2 3 2 2 2 1 3 2 1 3 2 |
__________________________________________________________________________|
Parathyroid Gland | M + M + M + + + M M + M + + + + + + M M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Inflammation, Chronic, Multifocal | |
Follicle, Cyst, Multiple | 2 2|
Follicular Cell, Hyperplasia, Focal | |
Follicular Cell, Hyperplasia, | |
Multifocal | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 2| 2| 6| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| 3|
| 9| 7| 9| 9| 2| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 9| 0| 1| 0| 0| 9| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + |
Ectasia | 2 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + M + + + + + +|
Ectasia, Multifocal | 2 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | M M M + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + M + + + + M + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 2 2|
Hemorrhage, Acute | 3 2 3 3 3 3 3 2 2 3 3 1|
Hemorrhage, Subacute | 2 2 2 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 4 2 3 4 3 3 2 4 |
Hyperplasia, Lymphoid | 2 |
Necrosis, Focal, Subacute | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + M + M + + + + + +|
Cyst | |
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M + M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + M + + + + + + + + + + + + + + + + + + + + + +|
Prepuce, Inflammation, Chronic Active| 4 |
Prepuce, Ulcer | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Inflammation, | |
Focal, Granulomatous | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 2| 2| 6| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| 3|
| 9| 7| 9| 9| 2| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 9| 0| 1| 0| 0| 9| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 3 3 3 2 2 1 3 1 2 1 3 1 3 2 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolus, Infiltration Cellular, | |
Focal, Histiocyte | |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 2 3 2 |
Mediastinum, Infiltration Cellular, | |
Multifocal, Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 1 |
Mucosa, Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 |
Respiratory Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Infiltration Cellular, Lymphocyte | 2 1 2 1 1 2 2 1 |
Mineralization, Multifocal | |
Nephropathy, Chronic | 1 2 |
Bilateral, Hydronephrosis | |
Bilateral, Pelvis, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 2| 2| 6| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| 3|
| 9| 7| 9| 9| 2| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 9| 0| 1| 0| 0| 9| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Medulla, Necrosis, Acute, Focal | |
Proximal Convoluted Renal Tubule, | |
Necrosis, Acute, Multifocal | |
Renal Tubule, Hyperplasia, Multifocal| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Diffuse | 2 |
Inflammation, Chronic, Multifocal | |
Inflammation, Chronic Active, Diffuse| |
Ulcer, Multifocal | |
Transitional Epithelium, Hyperplasia,| |
Atypical, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 2| 4| 3| 3| 3| 3| 3| 2| 0| 6| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 9| 2| 9| 5| |
| 9| 9| 6| 1| 1| 1| 1| 1| 9| 4| 2| 1| 4| 1| 1| 9| 1| 1| 1| 1| 9| 0| 9| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + + + A M + M + + + M M + + + + + + +| 40 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 3 2 | 6 2.7|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lumen, Hemorrhage, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| 45 |
Peyer's Patch, Hyperplasia, Lymphoid | 2| 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + M + + + + + + + + + + + + + +| 46 |
Lumen, Hemorrhage, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 2 |
Basophilic Focus, Multiple | | 1 |
Cytomegaly, Multifocal | 3 | 1 3.0|
Eosinophilic Focus | X | 1 |
Fatty Change, Focal | 2 | 1 2.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | | 1 |
Hyperplasia, Multifocal, Nodular | 3 | 1 3.0|
Infarct | 4 | 2 4.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 3 1 2 | 4 2.0|
Inflammation, Chronic, Multifocal | 2 | 1 2.0|
Inflammation, Multifocal, Subacute | 2 | 2 2.0|
Mixed Cell Focus | X | 1 |
Necrosis, Acute, Multifocal | 3 4 | 3 3.7|
Bile Duct, Hyperplasia, Multifocal | 4 4 | 4 2.8|
Centrilobular, Fatty Change, | | |
Multifocal | 1 | 2 1.5|
Centrilobular, Necrosis, Diffuse | 4 | 1 4.0|
Oval Cell, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 2| 4| 3| 3| 3| 3| 3| 2| 0| 6| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 9| 2| 9| 5| |
| 9| 9| 6| 1| 1| 1| 1| 1| 9| 4| 2| 1| 4| 1| 1| 9| 1| 1| 1| 1| 9| 0| 9| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Focal | 2 | 1 2.0|
Duct, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 1 3 1 2 1 1 1 1 1 1 1 | 25 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + M + + + + + + + + + + + + + + + + + + +| 46 |
Inflammation, Chronic Active, Focal | 2 | 1 2.0|
Ulcer | 1 | 1 1.0|
Epithelium, Hyperplasia, Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Mucosa, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + | 3 |
Dysplasia | 3 2 | 2 2.5|
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Artery, Inflammation, Chronic, | | |
Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcapsular, Hyperplasia, Focal | 2 1 | 4 2.3|
Subcapsular, Hyperplasia, Multifocal | 2 1 2 2 1 2 2 2 3 2 1 2 2 1 2 2| 32 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 2 2 2 | 5 2.4|
Hyperplasia, Multifocal | | 1 4.0|
Hypertrophy, Focal | 3 2 2 2 | 6 2.2|
Hypertrophy, Multifocal | 3 3 | 6 2.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M| 47 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 | 1 2.0|
Hyperplasia, Multifocal | 2 2 2 3 2 | 18 2.1|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + M + M M + M + + M + M + M + + + M| 33 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 2| 4| 3| 3| 3| 3| 3| 2| 0| 6| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 9| 2| 9| 5| |
| 9| 9| 6| 1| 1| 1| 1| 1| 9| 4| 2| 1| 4| 1| 1| 9| 1| 1| 1| 1| 9| 0| 9| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | 1 | 1 1.0|
Inflammation, Chronic, Multifocal | 1 | 1 1.0|
Follicle, Cyst, Multiple | 2 | 3 2.0|
Follicular Cell, Hyperplasia, Focal | 2| 1 2.0|
Follicular Cell, Hyperplasia, | | |
Multifocal | 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | M + | 3 |
Ectasia | 4 | 2 3.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ectasia, Multifocal | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia, Lymphoid | 2 2 | 3 2.3|
Mediastinal, Hyperplasia, Lymphoid | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + M M M + + + + + M M + M + + M + + + + M + +| 37 |
Hyperplasia, Lymphoid | 3 | 2 2.5|
Hyperplasia | 4| 1 4.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +| 46 |
Hematopoietic Cell Proliferation | 2 2 1 3 1 3 2 2 4| 13 2.3|
Hemorrhage, Acute | 3 3 2 2 2 3 3 1 4 2 3 2 3 2 4| 27 2.6|
Hemorrhage, Subacute | 2 2 | 5 2.0|
Hyperplasia, Lymphoid | 2 | 3 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 2 3 2 3 4 3 4 3| 18 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 2| 4| 3| 3| 3| 3| 3| 2| 0| 6| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 9| 2| 9| 5| |
| 9| 9| 6| 1| 1| 1| 1| 1| 9| 4| 2| 1| 4| 1| 1| 9| 1| 1| 1| 1| 9| 0| 9| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 3 3 | 3 2.7|
Necrosis, Focal, Subacute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + M + + + + + + + + + +| 45 |
Cyst | 2 | 1 2.0|
Depletion Lymphoid | 3 3 | 2 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Necrosis | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M + M M + M M M M M M M M M M M M +| 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Prepuce, Inflammation, Chronic Active| 4 | 2 4.0|
Prepuce, Ulcer | 4 | 1 4.0|
Subcutaneous Tissue, Edema | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Focal, Granulomatous | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrous Osteodystrophy | 2| 3 1.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization, Multifocal | 2 3 1 1 2 2 2 3 3 2 2 1 2 2 3 3| 31 2.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Acute | 3 2 | 2 2.5|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 | 4 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 2 1.5|
Alveolus, Infiltration Cellular, | | |
Focal, Histiocyte | 2 | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 2 2 2 | 6 2.2|
Mediastinum, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| |
DAY ON TEST | 2| 2| 4| 3| 3| 3| 3| 3| 2| 0| 6| 3| 5| 3| 3| 2| 3| 3| 3| 3| 2| 9| 2| 9| 5| |
| 9| 9| 6| 1| 1| 1| 1| 1| 9| 4| 2| 1| 4| 1| 1| 9| 1| 1| 1| 1| 9| 0| 9| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Multifocal, Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lumen, Exudate | | 1 1.0|
Mucosa, Inflammation, Chronic Active | 1 | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 1 2 1 1 1 | 18 1.3|
Mineralization, Multifocal | 1 1 | 2 1.0|
Nephropathy, Chronic | 2 | 3 1.7|
Bilateral, Hydronephrosis | 2 2| 2 2.0|
Bilateral, Pelvis, Inflammation, | | |
Acute | 2 4 | 2 3.0|
Medulla, Necrosis, Acute, Focal | 2| 1 2.0|
Proximal Convoluted Renal Tubule, | | |
Necrosis, Acute, Multifocal | 3 | 1 3.0|
Renal Tubule, Hyperplasia, Multifocal| 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic, Diffuse | | 1 2.0|
Inflammation, Chronic, Multifocal | 2 | 1 2.0|
Inflammation, Chronic Active, Diffuse| 4 4 | 2 4.0|
Ulcer, Multifocal | 4 | 1 4.0|
Transitional Epithelium, Hyperplasia,| | |
Atypical, Diffuse | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 4| 2| 6| 7| 7| 5| 7| 5| 6| 7| 7| 5| 5|
DAY ON TEST | 6| 2| 2| 2| 3| 7| 4| 3| 2| 1| 2| 4| 8| 9| 8| 2| 1| 8| 2| 9| 2| 2| 2| 5| 5|
| 0| 9| 9| 9| 0| 1| 9| 0| 9| 4| 9| 2| 5| 9| 4| 9| 8| 8| 9| 1| 5| 9| 9| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M M + M + + + + A + + + M + + M M + + + + + + A|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + A A + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + A|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + A + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + M + + + A + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + A + + + A + + + + + + A + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Cytoplasmic Alteration, Multifocal | 1 |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Hepatodiaphragmatic Nodule | |
Infarct | 4 4 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 |
Inflammation, Chronic, Multifocal | 1 2|
Necrosis, Acute, Multifocal | 4 |
Thrombosis | |
Bile Duct, Hyperplasia, Multifocal | 2|
Centrilobular, Fatty Change, | |
Multifocal | 2 |
Centrilobular, Necrosis, Acute, | |
Multifocal | |
Centrilobular, Necrosis, Diffuse | 4 |
Kupffer Cell, Hyperplasia, Multifocal| |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 4 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 4| 2| 6| 7| 7| 5| 7| 5| 6| 7| 7| 5| 5|
DAY ON TEST | 6| 2| 2| 2| 3| 7| 4| 3| 2| 1| 2| 4| 8| 9| 8| 2| 1| 8| 2| 9| 2| 2| 2| 5| 5|
| 0| 9| 9| 9| 0| 1| 9| 0| 9| 4| 9| 2| 5| 9| 4| 9| 8| 8| 9| 1| 5| 9| 9| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 2 |
Inflammation, Chronic | |
Mucosa, Mineralization | 2 |
__________________________________________________________________________|
Tooth | + + + + + + |
Dysplasia | 4 4 4 4 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 4 3 |
Inflammation, Chronic Active | 3 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Multifocal | |
Inflammation, Chronic, Multifocal | 3 |
Mitral Valve, Bacterium | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Accessory Adrenal Cortical | |
Nodule | X X |
Subcapsular, Hyperplasia, Focal | 4|
Subcapsular, Hyperplasia, Multifocal | 2 2 2 1 1 1 1 2 1 2 1 1 1 1 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
Hypertrophy, Focal | 2 1 1 2 |
Hypertrophy, Multifocal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal | 2 2 1 2 1 3 2 4 3 2 3|
__________________________________________________________________________|
Parathyroid Gland | M + + + M + + M + M + M + + + M M + M + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 2 |
Follicle, Cyst, Multiple | |
Follicular Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 4| 2| 6| 7| 7| 5| 7| 5| 6| 7| 7| 5| 5|
DAY ON TEST | 6| 2| 2| 2| 3| 7| 4| 3| 2| 1| 2| 4| 8| 9| 8| 2| 1| 8| 2| 9| 2| 2| 2| 5| 5|
| 0| 9| 9| 9| 0| 1| 9| 0| 9| 4| 9| 2| 5| 9| 4| 9| 8| 8| 9| 1| 5| 9| 9| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Multifocal | 4 |
__________________________________________________________________________|
Penis | + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + |
Atrophy | 4 |
Ectasia | 4 |
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation, Acute, Suppurative | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Re Cell | 2 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Plasma Cell | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | 3 |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + M + + + + + + + + M M +|
Hyperplasia, Lymphoid | 3 2 |
Hyperplasia, Re Cell | 3 2 |
Pigmentation, Hemosiderin | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + M + + + + M + M + + + + + + + + + + +|
Angiectasis | 4 |
Hematopoietic Cell Proliferation | 2 2 1 |
Hemorrhage, Acute | 2 2 3 3 4 3 2 1 3|
Hemorrhage, Subacute | |
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | |
Fibrosis, Diffuse | |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 2|
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Thymus | + + + + M M M + + + + + + + + M M + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 4| 2| 6| 7| 7| 5| 7| 5| 6| 7| 7| 5| 5|
DAY ON TEST | 6| 2| 2| 2| 3| 7| 4| 3| 2| 1| 2| 4| 8| 9| 8| 2| 1| 8| 2| 9| 2| 2| 2| 5| 5|
| 0| 9| 9| 9| 0| 1| 9| 0| 9| 4| 9| 2| 5| 9| 4| 9| 8| 8| 9| 1| 5| 9| 9| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Depletion Lymphoid | 3 4 4 4 |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M + M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + M + + +|
Prepuce, Inflammation, Chronic Active| |
Prepuce, Ulcer | |
Subcutaneous Tissue, Abscess, Chronic| 4 |
Subcutaneous Tissue, Inflammation, | |
Diffuse, Subacute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteoporosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage, Acute, Multifocal | |
Infarct, Subacute | |
Inflammation, Acute, Focal | |
Mineralization, Multifocal | 2 1 3 2 2 3 2 2 1 2 2 2 1 1 3 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + M + + + + + + + M + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 4 4 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Inflammation, Acute, Focal | |
Necrosis, Acute, Multifocal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 4 2 2 2 2 2 4 2 4 4 3 1 2 3 2 4 4 3 4 3 2 3|
Alveolus, Infiltration Cellular, | |
Diffuse, Histiocyte | 2 4 |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 3 2 3 4 3 4 4 4 3 |
Bronchiole, Hyperplasia, Multifocal | 2 2 2 2 2 2 4 2 4 4 3 2 3 2 4 3 4 3 2 3|
Bronchiole, Alveolus, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 4| 2| 6| 7| 7| 5| 7| 5| 6| 7| 7| 5| 5|
DAY ON TEST | 6| 2| 2| 2| 3| 7| 4| 3| 2| 1| 2| 4| 8| 9| 8| 2| 1| 8| 2| 9| 2| 2| 2| 5| 5|
| 0| 9| 9| 9| 0| 1| 9| 0| 9| 4| 9| 2| 5| 9| 4| 9| 8| 8| 9| 1| 5| 9| 9| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Acute, Multifocal, Suppurative | 4 |
Mediastinum, Infiltration Cellular, | |
Multifocal, Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | 2 2 2 2 3 2 1 2 1 2 2 1 2 1 1 |
Mucosa, Inflammation, Acute | 1 |
Mucosa, Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Exudate | 3 |
Nasolacrimal Duct, Hyperplasia | 3 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Olfactory Epithelium, Atrophy | 1 |
Respiratory Epithelium, Hyperplasia | 1 1 |
Respiratory Epithelium, Ulcer, Focal | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | + |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Abscess, Multiple | |
Hydronephrosis | 2 |
Infarct | 3 4 2 |
Infiltration Cellular, Lymphocyte | 3 1 3 1 |
Mineralization, Multifocal | |
Bilateral, Pelvis, Inflammation, | |
Acute | |
Capsule, Fibrosis, Focal | 3 |
Renal Tubule, Hyperplasia, Atypical, | |
Focal | 2 |
Renal Tubule, Hyperplasia, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Chronic, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 3| 6| 5| 7| 5| 7| 6| 1| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 5| 5| |
DAY ON TEST | 1| 7| 5| 7| 2| 4| 3| 4| 4| 0| 1| 3| 5| 9| 1| 2| 1| 2| 3| 1| 3| 1| 5| 6| 1| |
| 7| 6| 2| 1| 9| 6| 0| 2| 5| 4| 7| 0| 9| 1| 4| 2| 0| 7| 7| 4| 0| 4| 4| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + M A + A + + + A + + + M + + M + + A + + A + A| 31 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + M A M + A + + + + + + + + + + A + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + A + + + + + + + + + + + + + + + + + M| 43 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + A + + + + + + + + + + + + + + + + A + A| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + M + + + + + + + A + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + M + + + + + + + A + + + + + + +| 42 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 2 |
Cytoplasmic Alteration, Multifocal | | 1 1.0|
Eosinophilic Focus | X | 1 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 | 2 2.0|
Hepatodiaphragmatic Nodule | X | 1 |
Infarct | | 2 4.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 3 1.7|
Inflammation, Chronic, Multifocal | | 2 1.5|
Necrosis, Acute, Multifocal | 4 | 2 4.0|
Thrombosis | 4 | 1 4.0|
Bile Duct, Hyperplasia, Multifocal | 1 3 | 3 2.0|
Centrilobular, Fatty Change, | | |
Multifocal | | 1 2.0|
Centrilobular, Necrosis, Acute, | | |
Multifocal | 4 | 1 4.0|
Centrilobular, Necrosis, Diffuse | | 1 4.0|
Kupffer Cell, Hyperplasia, Multifocal| 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 3| 6| 5| 7| 5| 7| 6| 1| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 5| 5| |
DAY ON TEST | 1| 7| 5| 7| 2| 4| 3| 4| 4| 0| 1| 3| 5| 9| 1| 2| 1| 2| 3| 1| 3| 1| 5| 6| 1| |
| 7| 6| 2| 1| 9| 6| 0| 2| 5| 4| 7| 0| 9| 1| 4| 2| 0| 7| 7| 4| 0| 4| 4| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Artery, Inflammation, Chronic Active | | 1 4.0|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 7 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Inflammation, Acute, Focal | | 1 2.0|
Inflammation, Chronic | 3| 1 3.0|
Mucosa, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + | 8 |
Dysplasia | 3 | 5 3.8|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 2 3.5|
Inflammation, Chronic Active | 3 | 3 3.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute, Multifocal | 3 | 1 3.0|
Inflammation, Chronic, Multifocal | | 1 3.0|
Mitral Valve, Bacterium | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Accessory Adrenal Cortical | | |
Nodule | X | 3 |
Subcapsular, Hyperplasia, Focal | 2 2 | 3 2.7|
Subcapsular, Hyperplasia, Multifocal | 1 1 2 1 1 1 2 2 2 1 1 2 | 28 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 3 | 4 2.3|
Hypertrophy, Focal | 2 2 2 | 7 1.7|
Hypertrophy, Multifocal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + M + + + + + + + + + + + + + +| 47 |
Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Multifocal | 3 2 3 2 1 1 2 3 3 1 2 1 | 23 2.1|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + M + + M M M + + + + + + M + + M + + + +| 34 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 3| 6| 5| 7| 5| 7| 6| 1| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 5| 5| |
DAY ON TEST | 1| 7| 5| 7| 2| 4| 3| 4| 4| 0| 1| 3| 5| 9| 1| 2| 1| 2| 3| 1| 3| 1| 5| 6| 1| |
| 7| 6| 2| 1| 9| 6| 0| 2| 5| 4| 7| 0| 9| 1| 4| 2| 0| 7| 7| 4| 0| 4| 4| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Cyst | 1 | 2 1.5|
Follicle, Cyst, Multiple | 2 2 | 2 2.0|
Follicular Cell, Hyperplasia, Focal | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + + + | 7 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Penis | + | 2 |
Inflammation, Chronic Active | 4 | 2 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + | 4 |
Atrophy | 3 | 2 3.5|
Ectasia | 4 3 | 3 3.7|
Inflammation, Chronic | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + M + + + + + + + + + + + + +| 46 |
Inflammation, Acute, Suppurative | 3 | 1 3.0|
Inflammation, Chronic Active | 4 3| 2 3.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | 4 | 1 4.0|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal, Re Cell | | 1 2.0|
Myeloid Cell, Hyperplasia | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bronchial, Hyperplasia, Lymphoid | 3 | 1 3.0|
Inguinal, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Hyperplasia | 2 2 | 3 2.3|
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + + + M + + + + M + + + + + + +| 43 |
Hyperplasia, Lymphoid | | 2 2.5|
Hyperplasia, Re Cell | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 3| 6| 5| 7| 5| 7| 6| 1| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 5| 5| |
DAY ON TEST | 1| 7| 5| 7| 2| 4| 3| 4| 4| 0| 1| 3| 5| 9| 1| 2| 1| 2| 3| 1| 3| 1| 5| 6| 1| |
| 7| 6| 2| 1| 9| 6| 0| 2| 5| 4| 7| 0| 9| 1| 4| 2| 0| 7| 7| 4| 0| 4| 4| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pigmentation, Hemosiderin | 3 | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + M + + M + M + + + + + + + + + + + + + + + M| 39 |
Angiectasis | | 1 4.0|
Hematopoietic Cell Proliferation | 2 3 | 5 2.0|
Hemorrhage, Acute | 4 3 4 2 3 3 3 2 4 3 | 19 2.8|
Hemorrhage, Subacute | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 3 | 4 2.5|
Hyperplasia, Re Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Multifocal | 3 | 1 3.0|
Fibrosis, Diffuse | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 4 2 2 2 3 2 | 8 2.4|
Hyperplasia, Lymphoid | 3 | 2 2.5|
Hyperplasia, Re Cell | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + M + + + M M + + M M + + M M M + + + + M + M + M| 32 |
Depletion Lymphoid | 4 4 | 6 3.8|
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M M M + M M M M M M M M M M M M M M + M M| 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Prepuce, Inflammation, Chronic Active| 4 4 4 | 3 4.0|
Prepuce, Ulcer | 3 3 4 | 3 3.3|
Subcutaneous Tissue, Abscess, Chronic| | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Diffuse, Subacute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteoporosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 6 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X | 1 |
Hemorrhage, Acute, Multifocal | 3 | 1 3.0|
Infarct, Subacute | 4 | 1 4.0|
Inflammation, Acute, Focal | 2 | 1 2.0|
Mineralization, Multifocal | 3 3 2 2 2 3 3 1 2 1 1 3 1 2 | 30 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 3| 6| 5| 7| 5| 7| 6| 1| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 5| 5| |
DAY ON TEST | 1| 7| 5| 7| 2| 4| 3| 4| 4| 0| 1| 3| 5| 9| 1| 2| 1| 2| 3| 1| 3| 1| 5| 6| 1| |
| 7| 6| 2| 1| 9| 6| 0| 2| 5| 4| 7| 0| 9| 1| 4| 2| 0| 7| 7| 4| 0| 4| 4| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Acute | 3 4 | 4 3.8|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
Inflammation, Acute, Focal | 4 | 1 4.0|
Necrosis, Acute, Multifocal | 2 3 | 2 2.5|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 3 3 4 3 3 1 4 2 2 3 3 4 3 2 4 3 3 3 1 4 4 2 2 | 45 2.8|
Alveolus, Infiltration Cellular, | | |
Diffuse, Histiocyte | | 2 3.0|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 3 3 4 3 2 2 4 3 3 3 3 | 20 3.2|
Bronchiole, Hyperplasia, Multifocal | 3 4 3 3 1 4 2 2 3 3 4 3 2 3 3 3 1 4 4 2 | 40 2.8|
Bronchiole, Alveolus, Inflammation, | | |
Acute, Multifocal, Suppurative | | 1 4.0|
Mediastinum, Infiltration Cellular, | | |
Multifocal, Lymphocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Lumen, Exudate | 2 1 3 1 2 2 2 3 3 3 2 2 3 1| 29 1.9|
Mucosa, Inflammation, Acute | | 1 1.0|
Mucosa, Inflammation, Chronic Active | 2 1 1 3 | 5 1.8|
Nasolacrimal Duct, Exudate | | 1 3.0|
Nasolacrimal Duct, Hyperplasia | | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 2 | 1 2.0|
Olfactory Epithelium, Atrophy | | 1 1.0|
Respiratory Epithelium, Hyperplasia | 2 1 1 | 5 1.2|
Respiratory Epithelium, Ulcer, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 3| 6| 5| 7| 5| 7| 6| 1| 6| 7| 7| 6| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 5| 5| |
DAY ON TEST | 1| 7| 5| 7| 2| 4| 3| 4| 4| 0| 1| 3| 5| 9| 1| 2| 1| 2| 3| 1| 3| 1| 5| 6| 1| |
| 7| 6| 2| 1| 9| 6| 0| 2| 5| 4| 7| 0| 9| 1| 4| 2| 0| 7| 7| 4| 0| 4| 4| 5| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 | 1 4.0|
Abscess, Multiple | 4 | 1 4.0|
Hydronephrosis | 3 | 2 2.5|
Infarct | | 3 3.0|
Infiltration Cellular, Lymphocyte | 1 2 2 | 7 1.9|
Mineralization, Multifocal | 3 | 1 3.0|
Bilateral, Pelvis, Inflammation, | | |
Acute | 3 | 1 3.0|
Capsule, Fibrosis, Focal | | 1 3.0|
Renal Tubule, Hyperplasia, Atypical, | | |
Focal | | 1 2.0|
Renal Tubule, Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 1 1.0|
Inflammation, Chronic, Diffuse | 4| 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 5| 6| 6| 0| 5| 7|
DAY ON TEST | 3| 7| 3| 3| 5| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 8| 4| 5| 3| 3| 3|
| 2| 8| 0| 0| 7| 0| 7| 0| 0| 0| 0| 0| 1| 1| 1| 1| 8| 2| 2| 8| 3| 7| 0| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + M + +|
__________________________________________________________________________|
Gallbladder | M + M + + + + + + + + + + + + + + + + + + A + +|
Ectasia | 4 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + M + + M + +|
Peyer's Patch, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + M + + + + + M + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + M + + + + + M + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + M + + + + M + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | 2 |
Basophilic Focus | X |
Fatty Change, Multifocal | 2 |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 |
Hyperplasia, Focal | 3 |
Infarct | 4 4 |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
Inflammation, Chronic, Multifocal | 1 |
Inflammation, Granulomatous, | |
Multifocal | |
Inflammation, Multifocal, Subacute | 1 2 1 |
Mitotic Alteration | 3 |
Necrosis, Acute, Multifocal | 4 |
Necrosis, Chronic, Multifocal | |
Pigmentation, Multifocal | |
Artery, Mineralization, Multifocal | |
Bile Duct, Hyperplasia, Multifocal | 3 1 |
Hepatocyte, Atrophy, Multifocal | |
__________________________________________________________________________|
Mesentery | |
Angiectasis, Multifocal | |
Fat, Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + M + + + + + M + +|
Infiltration Cellular, Multifocal, | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 5| 6| 6| 0| 5| 7|
DAY ON TEST | 3| 7| 3| 3| 5| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 8| 4| 5| 3| 3| 3|
| 2| 8| 0| 0| 7| 0| 7| 0| 0| 0| 0| 0| 1| 1| 1| 1| 8| 2| 2| 8| 3| 7| 0| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Lymphocyte | 2 1 1 1 1 1 2 1 2 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
Abscess | 4 |
Dysplasia | 4 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Inflammation, Chronic | |
Mesenteric Artery, Inflammation, | |
Chronic | |
Mesenteric Artery, Thrombosis | |
Renal Artery, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation, Chronic, Focal | 1 |
Aortic Valve, Inflammation, Chronic | |
Active, Focal | |
Epicardium, Hyperplasia, Focal | |
Mitral Valve, Inflammation, Focal, | |
Subacute | 3 |
Perivascular, Granuloma | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Subcapsular, Hyperplasia, Focal | 3 2 2 2 |
Subcapsular, Hyperplasia, Multifocal | 2 1 1 2 1 2 2 2 2 2 2 2 1 1|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + M + M + + + M + +|
Cyst | |
Hyperplasia, Focal | 3 3 1 2 2 |
Hyperplasia, Multifocal | 2 3 |
Hypertrophy, Focal | 3 2 |
Hypertrophy, Multifocal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + + + + + + + M + + + + + + M + M + + + M + +|
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | |
Hyperplasia, Multifocal | 4 |
__________________________________________________________________________|
Parathyroid Gland | + M M + M M + M + M + + + + + M M + M + + M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 5| 6| 6| 0| 5| 7|
DAY ON TEST | 3| 7| 3| 3| 5| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 8| 4| 5| 3| 3| 3|
| 2| 8| 0| 0| 7| 0| 7| 0| 0| 0| 0| 0| 1| 1| 1| 1| 8| 2| 2| 8| 3| 7| 0| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | 2 |
Pars Distalis, Cyst, Multiple | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + M + +|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | |
Granuloma Sperm | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | +|
Abscess | |
Ectasia | |
Inflammation, Chronic | 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia, Multifocal | 3 |
Granuloma | 4 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Inflammation, Chronic Active | |
Serosa, Inflammation, Acute, Focal, | |
Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia, | |
Diffuse | 2 2 |
Seminiferous Tubule, Atrophy, | |
Multifocal | 3 3 |
Seminiferous Tubule, Degeneration, | |
Multifocal | 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Focal, Osseous | |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia | 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M M + + + + M + + + M + + + M + M + +|
Hyperplasia, Lymphoid | 2 |
Pigmentation, Hemosiderin | 2 |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 5| 6| 6| 0| 5| 7|
DAY ON TEST | 3| 7| 3| 3| 5| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 8| 4| 5| 3| 3| 3|
| 2| 8| 0| 0| 7| 0| 7| 0| 0| 0| 0| 0| 1| 1| 1| 1| 8| 2| 2| 8| 3| 7| 0| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 3 |
Hemorrhage, Acute | 4 3 2 3 2 2 2 3 1 2 3 2|
Hemorrhage, Subacute | 1 2 2 |
Hyperplasia, Lymphoid | 3 2 3|
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Spleen | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 2 |
Hyperplasia, Lymphoid | 2|
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + M + + M M + M M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + M + +|
Prepuce, Inflammation, Chronic Active| |
Prepuce, Ulcer | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Inflammation, | |
Focal, Subacute | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternum, Developmental Malformation | 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 2 3 3 2 2 2 2 2 2 2 3 2 2 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + M + + + + + M + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | |
Hemorrhage, Subacute | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 4 1 3 2 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 1 1|
Alveolus, Infiltration Cellular, | |
Diffuse, Histiocyte | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 0| 7| 7| 5| 6| 6| 0| 5| 7|
DAY ON TEST | 3| 7| 3| 3| 5| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 3| 3| 8| 4| 5| 3| 3| 3|
| 2| 8| 0| 0| 7| 0| 7| 0| 0| 0| 0| 0| 1| 1| 1| 1| 8| 2| 2| 8| 3| 7| 0| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
0.5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | 2 2 3 |
Artery, Thrombosis, Multifocal | |
Bronchiole, Hyperplasia, Focal | 2 2 2 |
Bronchiole, Hyperplasia, Multifocal | 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Exudate | |
Mucosa, Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Respiratory Epithelium, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + M + + + + + + + + + + + M + + + + + M + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 2 2 |
Infarct | |
Infiltration Cellular, Plasma Cell | 2 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 2 2 1|
Nephropathy, Chronic | 1 1 |
Cortex, Cyst | |
Pelvis, Inflammation, Acute | |
Renal Tubule, Cytoplasmic Alteration,| |
Multifocal | |
Renal Tubule, Hyperplasia, Atypical, | |
Focal | |
Renal Tubule, Hyperplasia, Multifocal| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + M + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 5| 5| 6| 6| 7| 4| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 7| 0| 9| 3| 8| 2| 3| 3| 3| 3| 3| 2| 8| 6| 8| 9| 7| 3| 2| 4| 3| 2| 3| 3| |
| 2| 8| 6| 2| 2| 4| 9| 2| 2| 2| 2| 2| 2| 8| 6| 7| 2| 8| 2| 6| 3| 2| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + M + + + A M + + + + + A A + + + + + + + + + M| 39 |
Ectasia | | 1 4.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 3 1.7|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
Peyer's Patch, Hyperplasia, Lymphoid | 2 2| 3 2.7|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + M +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + M + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + A + + + + + + + + + + +| 48 |
Ectopic Tissue | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + M + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Multifocal | | 1 2.0|
Basophilic Focus | X | 2 |
Fatty Change, Multifocal | | 1 2.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 3 | 2 2.5|
Hyperplasia, Focal | | 1 3.0|
Infarct | 4 4 3 | 5 3.8|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 1.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 1.0|
Inflammation, Chronic, Multifocal | 1 1 | 3 1.0|
Inflammation, Granulomatous, | | |
Multifocal | 3 | 1 3.0|
Inflammation, Multifocal, Subacute | 2 | 4 1.5|
Mitotic Alteration | | 1 3.0|
Necrosis, Acute, Multifocal | 4 3 | 3 3.7|
Necrosis, Chronic, Multifocal | 2 | 1 2.0|
Pigmentation, Multifocal | 3 | 1 3.0|
Artery, Mineralization, Multifocal | 3 | 1 3.0|
Bile Duct, Hyperplasia, Multifocal | 1 | 3 1.7|
Hepatocyte, Atrophy, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 5| 5| 6| 6| 7| 4| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 7| 0| 9| 3| 8| 2| 3| 3| 3| 3| 3| 2| 8| 6| 8| 9| 7| 3| 2| 4| 3| 2| 3| 3| |
| 2| 8| 6| 2| 2| 4| 9| 2| 2| 2| 2| 2| 2| 8| 6| 7| 2| 8| 2| 6| 3| 2| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Angiectasis, Multifocal | 3 | 1 3.0|
Fat, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 2 2 1 1 1 1| 21 1.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tooth | | 2 |
Abscess | | 1 4.0|
Dysplasia | | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Inflammation, Chronic | 2 | 1 2.0|
Mesenteric Artery, Inflammation, | | |
Chronic | 3 | 1 3.0|
Mesenteric Artery, Thrombosis | 4 | 1 4.0|
Renal Artery, Inflammation, Chronic, | | |
Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 | 2 1.5|
Inflammation, Chronic, Focal | | 1 1.0|
Aortic Valve, Inflammation, Chronic | | |
Active, Focal | 2 | 1 2.0|
Epicardium, Hyperplasia, Focal | 2 | 1 2.0|
Mitral Valve, Inflammation, Focal, | | |
Subacute | | 1 3.0|
Perivascular, Granuloma | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Subcapsular, Hyperplasia, Focal | | 4 2.3|
Subcapsular, Hyperplasia, Multifocal | 2 3 2 1 1 1 1 1 2 2 1 2 2| 27 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst | 3 | 1 3.0|
Hyperplasia, Focal | 2 2 | 7 2.1|
Hyperplasia, Multifocal | 2 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 5| 5| 6| 6| 7| 4| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 7| 0| 9| 3| 8| 2| 3| 3| 3| 3| 3| 2| 8| 6| 8| 9| 7| 3| 2| 4| 3| 2| 3| 3| |
| 2| 8| 6| 2| 2| 4| 9| 2| 2| 2| 2| 2| 2| 8| 6| 7| 2| 8| 2| 6| 3| 2| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hypertrophy, Focal | 2 | 3 2.3|
Hypertrophy, Multifocal | 3 1| 3 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + + M + + + +| 43 |
Hyperplasia, Focal | | 1 2.0|
Hyperplasia, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 2 2 | 2 2.0|
Hyperplasia, Multifocal | 2 2 2 3 1 2 | 7 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + M + + + + M + + M + + + + + + M M + + M| 30 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Cyst, Multiple | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Follicle, Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma | 3 | 1 3.0|
Granuloma Sperm | 2 | 1 2.0|
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 4 |
Abscess | 4 4 | 2 4.0|
Ectasia | 4 | 1 4.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + M M + + + + + + + + + + + + + + + + + +| 48 |
Ectasia, Multifocal | | 1 3.0|
Granuloma | | 1 4.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Serosa, Inflammation, Acute, Focal, | | |
Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 4 | 3 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 5| 5| 6| 6| 7| 4| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 7| 0| 9| 3| 8| 2| 3| 3| 3| 3| 3| 2| 8| 6| 8| 9| 7| 3| 2| 4| 3| 2| 3| 3| |
| 2| 8| 6| 2| 2| 4| 9| 2| 2| 2| 2| 2| 2| 8| 6| 7| 2| 8| 2| 6| 3| 2| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Diffuse | | 2 2.0|
Seminiferous Tubule, Atrophy, | | |
Multifocal | 2 3 3 2 2 2 | 8 2.5|
Seminiferous Tubule, Degeneration, | | |
Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Focal, Osseous | 2 | 1 2.0|
Myeloid Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inguinal, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + M + + + + + + + + + M M + + + + + +| 39 |
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 3 3 3 | 7 2.6|
Hemorrhage, Acute | 2 3 3 3 3 2 4 2 2 2 2 2 2| 25 2.4|
Hemorrhage, Subacute | | 3 1.7|
Hyperplasia, Lymphoid | 1| 4 2.3|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 3 2 2 3 4 4 | 10 2.7|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M M + + + + + M + + M M + + M + + + + +| 38 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M + M M M M M M M M M + M M M M M + M M| 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Prepuce, Inflammation, Chronic Active| 4 | 1 4.0|
Prepuce, Ulcer | 4 | 1 4.0|
Subcutaneous Tissue, Edema | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Focal, Subacute | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sternum, Developmental Malformation | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 5| 5| 6| 6| 7| 4| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 7| 0| 9| 3| 8| 2| 3| 3| 3| 3| 3| 2| 8| 6| 8| 9| 7| 3| 2| 4| 3| 2| 3| 3| |
| 2| 8| 6| 2| 2| 4| 9| 2| 2| 2| 2| 2| 2| 8| 6| 7| 2| 8| 2| 6| 3| 2| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization, Multifocal | 2 2 2 3 3 3 3 2 1 1 2 2 2 1| 29 2.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + M + + + M + + + + + + + + + + + + + + + + + + +| 46 |
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 1 | 2 1.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Acute | 4 | 1 4.0|
Hemorrhage, Subacute | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
Thrombosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 2 2 1 3 4| 13 2.2|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 2 3 2 2 1 | 8 1.8|
Alveolus, Infiltration Cellular, | | |
Diffuse, Histiocyte | 2 | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 2 | 4 2.3|
Artery, Thrombosis, Multifocal | 4 | 1 4.0|
Bronchiole, Hyperplasia, Focal | 1 | 4 1.8|
Bronchiole, Hyperplasia, Multifocal | 2 2 1 2 | 5 1.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumen, Exudate | 1 | 1 1.0|
Mucosa, Inflammation, Chronic Active | 1 | 2 1.5|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 1 | 1 1.0|
Respiratory Epithelium, Hyperplasia | 1 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05072-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TETRANITROMETHANE Date: 04/17/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:26:06
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 6| 6| 5| 5| 6| 6| 7| 4| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 7| 0| 9| 3| 8| 2| 3| 3| 3| 3| 3| 2| 8| 6| 8| 9| 7| 3| 2| 4| 3| 2| 3| 3| |
| 2| 8| 6| 2| 2| 4| 9| 2| 2| 2| 2| 2| 2| 8| 6| 7| 2| 8| 2| 6| 3| 2| 1| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
0.5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | | 3 2.0|
Infarct | 1 | 1 1.0|
Infiltration Cellular, Plasma Cell | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 1 1 1 4 3 | 15 1.5|
Nephropathy, Chronic | 1 1 1| 5 1.0|
Cortex, Cyst | 2 | 1 2.0|
Pelvis, Inflammation, Acute | 2 | 1 2.0|
Renal Tubule, Cytoplasmic Alteration,| | |
Multifocal | 2 | 1 2.0|
Renal Tubule, Hyperplasia, Atypical, | | |
Focal | 2 1 | 2 1.5|
Renal Tubule, Hyperplasia, Multifocal| 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
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