TR 386 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Midwest Research Inst DATE: 09/09/94
EXP: 05072 TETRANITROMETHANE TIME: 03:28:53
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 55947
CONT: N01ES38042 CAS: 509-14-8
PATHOLOGIST: M. STEDHAM
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Midwest Research Inst DATE: 09/09/94
EXP: 05072 TETRANITROMETHANE TIME: 03:28:53
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 55947
CONT: N01ES38042 CAS: 509-14-8
PATHOLOGIST: M. STEDHAM
TETRANITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 504 629 639 646 654 654 662 662 674 677 |
| 690 691 698 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 2 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 426 534 566 580 587 588 592 621 622 629 |
| 643 643 657 657 657 678 678 678 684 688 |
| 692 706 |
| CENSORED DEATHS |
| 30 48 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 35 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| 145 299 376 485 513 514 537 546 553 555 |
| 560 565 571 588 591 604 614 614 625 627 |
| 642 642 649 652 654 659 671 684 691 710 |
| 714 717 717 718 722 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TETRANITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 98.0 84.0 74.0 |
| | |
| | |
|0.5 PPM | 100.0 100.0 100.0 100.0 100.0 97.9 95.8 85.4 68.8 54.2 |
| | |
| | |
|2 PPM | 100.0 98.0 98.0 96.0 94.0 92.0 86.0 68.0 48.0 30.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.5 PPM 2 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 74.0% 54.2% 30.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.046 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 652.3 627.5 592.1 |
|NATURAL DEATHS (C) | (13.6) (13.8) (20.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 709.1 656.8 633.2 |
|(STANDARD ERROR) | ( 5.9) (20.3) (17.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TETRANITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 2 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 214 544 563 590 603 605 606 613 619 619 |
| 627 629 642 642 655 657 704 |
| CENSORED DEATHS |
| 382 480 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 1 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 263 335 389 524 576 592 601 601 612 665 |
| 666 692 692 693 699 701 703 706 715 716 |
| 718 |
| CENSORED DEATHS |
| 128 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 261 444 446 520 521 535 546 565 612 633 |
| 645 666 673 674 681 684 686 687 698 698 |
| 703 703 703 705 714 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TETRANITROMETHANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 98.0 98.0 98.0 98.0 95.9 87.6 66.7 64.6 |
| | |
| | |
|0.5 PPM | 100.0 100.0 98.0 95.9 93.9 93.9 91.8 83.7 79.6 57.1 |
| | |
| | |
|2 PPM | 100.0 100.0 98.0 98.0 98.0 94.0 88.0 84.0 78.0 48.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.5 PPM 2 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 64.6% 57.1% 48.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.190 P=0.703 P=0.239 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 596.0 612.3 620.3 |
|NATURAL DEATHS (C) | (25.5) (28.8) (21.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 671.9 668.0 672.5 |
|(STANDARD ERROR) | (14.2) (18.2) (13.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TETRANITROMETHANE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.5 PPM = 2
2 PPM = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
| 3 3 2 1 2 1
| 3 3 3 2 2 2 1 11
| 3 3 22 11
90 +
| 3 3 2 2 1 1
P | 333 2 2 1 1
E | 33 22
R 80 + 2 2 1 1
C | 33
E | 33 3 2 2 11 1
N | 3 3
T 70 + 3 3 2 2
| 33
S | 3 3
U | 22
R 60 + 3 3 22
V | 2 2
I | 333 2 2
V |
A 50 + 3 3
L | 33
| 3 33
| 3 3
40 +
| 33
|
| 33
30 + 3 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 10 obs hidden.
TETRANITROMETHANE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.5 PPM = 2
2 PPM = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2
| 1 2 2 3 1
| 2 2 3 2 1 1 1
| 2 2 1 1
P 90 + 3 3 2 2
E | 33 22
R | 3 3 11
C | 2 11 3 2
E 80 + 113 3 22
N | 3 2 2
T | 1 1 33
| 3322
S 70 + 1 1 22
U | 1 1
R | 3331 1
V | 2 2
I 60 + 33
V | 2 2
A |
L | 33
50 + 3 3
| 3 3
|
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.
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