TR 386 Rat Pathology Tables
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
Facility: Midwest Research Institute
Chemical CAS #: 509-14-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 5| 4| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 4| 2| 2| 1| 2| 0| 2| 2| 2| 2| 9| 5| 2| 7| 4| 9| 2| 2| 5| 2| 2| 2| 2| 2|
| 9| 4| 7| 7| 0| 7| 2| 7| 7| 7| 8| 0| 9| 5| 4| 8| 1| 8| 8| 4| 8| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + + M + + M + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X|
Pars Distalis, Adenoma, Two | |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 5| 4| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 4| 2| 2| 1| 2| 0| 2| 2| 2| 2| 9| 5| 2| 7| 4| 9| 2| 2| 5| 2| 2| 2| 2| 2|
| 9| 4| 7| 7| 0| 7| 2| 7| 7| 7| 8| 0| 9| 5| 4| 8| 1| 8| 8| 4| 8| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X |
Bilateral, Polyp Stromal | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + M + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | X X X X X |
Fibroadenoma, Two | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Sarcoma | |
Vulva, Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Benign | X |
Leukemia Mononuclear | X |
Cerebellum, Meningioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 6| 7| 6| 5| 4| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 4| 2| 2| 1| 2| 0| 2| 2| 2| 2| 9| 5| 2| 7| 4| 9| 2| 2| 5| 2| 2| 2| 2| 2|
| 9| 4| 7| 7| 0| 7| 2| 7| 7| 7| 8| 0| 9| 5| 4| 8| 1| 8| 8| 4| 8| 8| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Mediastinum, Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 2| 7| 5| 6| 7| 6| 0| 6| |
DAY ON TEST | 9| 2| 4| 2| 2| 2| 2| 2| 5| 2| 3| 2| 2| 2| 7| 2| 5| 5| 2| 1| 0| 2| 5| 0| 9| |
| 5| 9| 6| 9| 9| 9| 9| 9| 7| 0| 8| 7| 5| 7| 3| 7| 8| 1| 7| 3| 6| 7| 9| 8| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + A + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + M + + + + + A A + + + M| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X X X| 17 |
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X| 9 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + M + + + + + + + + M + M + + + + + + + + + M +| 43 |
Leukemia Mononuclear | X X X| 7 |
Pheochromocytoma Benign | X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + M M + + + + + + M +| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 5 |
Pars Distalis, Adenoma | X X X X X X X X X X X X| 27 |
Pars Distalis, Adenoma, Two | X | 1 |
Pars Distalis, Carcinoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 2| 7| 5| 6| 7| 6| 0| 6| |
DAY ON TEST | 9| 2| 4| 2| 2| 2| 2| 2| 5| 2| 3| 2| 2| 2| 7| 2| 5| 5| 2| 1| 0| 2| 5| 0| 9| |
| 5| 9| 6| 9| 9| 9| 9| 9| 7| 0| 8| 7| 5| 7| 3| 7| 8| 1| 7| 3| 6| 7| 9| 8| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
C-Cell, Adenoma | X | 3 |
C-Cell, Carcinoma | X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + M +| 47 |
Adenoma | | 1 |
Carcinoma | | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Polyp Stromal | X X X X X X | 9 |
Bilateral, Polyp Stromal | X X | 2 |
__________________________________________________________________________|____________|
Vagina | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
Mediastinal, Leukemia Mononuclear | X X X X | 6 |
Pancreatic, Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
Leukemia Mononuclear | X X | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X| 18 |
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + M +| 48 |
Fibroadenoma | X X | 7 |
Fibroadenoma, Two | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 7| 7| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 7| 6| 2| 7| 5| 6| 7| 6| 0| 6| |
DAY ON TEST | 9| 2| 4| 2| 2| 2| 2| 2| 5| 2| 3| 2| 2| 2| 7| 2| 5| 5| 2| 1| 0| 2| 5| 0| 9| |
| 5| 9| 6| 9| 9| 9| 9| 9| 7| 0| 8| 7| 5| 7| 3| 7| 8| 1| 7| 3| 6| 7| 9| 8| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Keratoacanthoma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
Subcutaneous Tissue, Sarcoma | X | 1 |
Vulva, Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Astrocytoma Benign | | 1 |
Leukemia Mononuclear | | 1 |
Cerebellum, Meningioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + M + + + + + M +| 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X| 13 |
Mediastinum, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 4 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X| 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 6| 5| 5| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 6| 5| 4|
DAY ON TEST | 1| 1| 7| 0| 9| 5| 7| 1| 2| 9| 2| 1| 2| 2| 2| 4| 2| 2| 2| 2| 0| 3| 8| 7| 9|
| 6| 4| 0| 2| 6| 8| 0| 2| 1| 0| 8| 7| 8| 0| 8| 5| 8| 6| 2| 8| 0| 3| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Leukemia | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
Leukemia | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Leukemia | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyoma | |
Leukemia | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + A + + + + + + + + + + + + + + + + +|
Leukemia | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + A A + + + A A + + + + + + + + + + + + + + + + +|
Leukemia | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Hepatocellular Carcinoma | X |
Leukemia | X |
Leukemia Mononuclear | X |
Sarcoma, Metastatic, Lung | X |
__________________________________________________________________________|
Mesentery | + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Leukemia, Multifocal | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
Sarcoma, Metastatic, Uterus | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X X |
Leukemia | X |
Mixed Tumor Malignant, Metastatic, | |
Lung | X |
Sarcoma, Metastatic, Lung | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Leukemia | X |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 6| 5| 5| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 6| 5| 4|
DAY ON TEST | 1| 1| 7| 0| 9| 5| 7| 1| 2| 9| 2| 1| 2| 2| 2| 4| 2| 2| 2| 2| 0| 3| 8| 7| 9|
| 6| 4| 0| 2| 6| 8| 0| 2| 1| 0| 8| 7| 8| 0| 8| 5| 8| 6| 2| 8| 0| 3| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Multiple, Metastatic, Lung | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X X |
Leukemia | X |
Sarcoma, Multiple, Metastatic, Lung | |
Epicardium, Carcinoma, Metastatic, | |
Lung | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Leukemia | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X X X |
Carcinoma | X |
Carcinoma, Metastatic, Lung | |
Leukemia Mononuclear | X |
Medulla, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + M + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Complex | |
Pheochromocytoma Benign | X |
Sarcoma, Metastatic, Lung | |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X |
Pars Distalis, Adenoma, Two | |
Pars Distalis, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 6| 5| 5| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 6| 5| 4|
DAY ON TEST | 1| 1| 7| 0| 9| 5| 7| 1| 2| 9| 2| 1| 2| 2| 2| 4| 2| 2| 2| 2| 0| 3| 8| 7| 9|
| 6| 4| 0| 2| 6| 8| 0| 2| 1| 0| 8| 7| 8| 0| 8| 5| 8| 6| 2| 8| 0| 3| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Alveolar/Bronchiolar Carcinoma, | |
Multiple, Metastatic, Lung | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
Squamous Cell Carcinoma, Metastatic, | |
Lung | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + M + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + I + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X X X |
Leukemia | X |
Leukemia Mononuclear | |
Bilateral, Carcinoma, Metastatic, | |
Lung | |
Bilateral, Sarcoma, Metastatic, Lung | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia | X |
Polyp Stromal | X X X |
Sarcoma | X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | I |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Lung | X |
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X X X X |
Mediastinal, Carcinoma, Metastatic, | |
Lung | |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | |
Serosa, Mediastinal, Sarcoma, | |
Metastatic, Uncertain Primary | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 6| 5| 5| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 6| 5| 4|
DAY ON TEST | 1| 1| 7| 0| 9| 5| 7| 1| 2| 9| 2| 1| 2| 2| 2| 4| 2| 2| 2| 2| 0| 3| 8| 7| 9|
| 6| 4| 0| 2| 6| 8| 0| 2| 1| 0| 8| 7| 8| 0| 8| 5| 8| 6| 2| 8| 0| 3| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Site | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia | X |
Leukemia Mononuclear | X X |
Squamous Cell Carcinoma, Metastatic, | |
Lung | |
__________________________________________________________________________|
Thymus | + + M + + + M M + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X X |
Leukemia | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Fibroadenoma | X |
Fibroadenoma, Two | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic | |
Subcutaneous Tissue, | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Subcutaneous Tissue, Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 6| 5| 5| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 6| 5| 4|
DAY ON TEST | 1| 1| 7| 0| 9| 5| 7| 1| 2| 9| 2| 1| 2| 2| 2| 4| 2| 2| 2| 2| 0| 3| 8| 7| 9|
| 6| 4| 0| 2| 6| 8| 0| 2| 1| 0| 8| 7| 8| 0| 8| 5| 8| 6| 2| 8| 0| 3| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X X|
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X X X X X X X X X X X X X X X X X X X X X |
Alveolar/Bronchiolar Carcinoma, Two | X X |
Leukemia | X |
Leukemia Mononuclear | X |
Mixed Tumor Malignant, Multiple | X |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | X |
Sarcoma, Multiple | |
Squamous Cell Carcinoma | X X X X X X |
Squamous Cell Carcinoma, Multiple | X |
Mediastinum, Carcinoma, Metastatic, | |
Lung | |
Mediastinum, Leukemia | X |
Mediastinum, Squamous Cell Carcinoma,| |
Metastatic, Lung | X |
Pleura, Mediastinum, Sarcoma, | |
Metastatic, Uncertain Primary | |
Site | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Multiple, Metastatic, Lung | X |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X X X X |
Carcinoma, Metastatic, Lung | |
Leukemia | X |
Leukemia Mononuclear | X |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | X |
Sarcoma, Metastatic, Lung | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 6| 6| 5| 5| 7| 5| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7| 6| 6| 5| 4|
DAY ON TEST | 1| 1| 7| 0| 9| 5| 7| 1| 2| 9| 2| 1| 2| 2| 2| 4| 2| 2| 2| 2| 0| 3| 8| 7| 9|
| 6| 4| 0| 2| 6| 8| 0| 2| 1| 0| 8| 7| 8| 0| 8| 5| 8| 6| 2| 8| 0| 3| 8| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Leukemia | X |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7| |
DAY ON TEST | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2| |
| 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
Leukemia | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
Leukemia | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leiomyoma | X| 1 |
Leukemia | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A +| 46 |
Leukemia | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + A +| 43 |
Leukemia | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Hepatocellular Carcinoma | | 1 |
Leukemia | | 1 |
Leukemia Mononuclear | X X X X | 5 |
Sarcoma, Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 8 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Leukemia, Multifocal | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Sarcoma, Metastatic, Uterus | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 3 |
Leukemia | | 1 |
Mixed Tumor Malignant, Metastatic, | | |
Lung | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7| |
DAY ON TEST | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2| |
| 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Sarcoma, Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Leukemia | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple, Metastatic, Lung | X | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 3 |
Leukemia | | 1 |
Sarcoma, Multiple, Metastatic, Lung | X | 1 |
Epicardium, Carcinoma, Metastatic, | | |
Lung | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Leukemia | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 3 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X X | 5 |
Carcinoma | | 1 |
Carcinoma, Metastatic, Lung | X | 1 |
Leukemia Mononuclear | X X | 3 |
Medulla, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + + + + + + + + + + + + + + + + + + + + +| 45 |
Leukemia Mononuclear | X | 1 |
Pheochromocytoma Complex | X | 1 |
Pheochromocytoma Benign | X | 2 |
Sarcoma, Metastatic, Lung | X | 1 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7| |
DAY ON TEST | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2| |
| 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
Pars Distalis, Adenoma | X X X X X X X X X X X| 24 |
Pars Distalis, Adenoma, Two | X | 1 |
Pars Distalis, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Adenoma | X | 4 |
C-Cell, Carcinoma | X | 1 |
Follicular Cell, Adenoma | X | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 3 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple, Metastatic, Lung | X | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Lung | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X X | 5 |
Leukemia | | 1 |
Leukemia Mononuclear | X | 1 |
Bilateral, Carcinoma, Metastatic, | | |
Lung | X | 1 |
Bilateral, Sarcoma, Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia | | 1 |
Polyp Stromal | X X | 5 |
Sarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7| |
DAY ON TEST | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2| |
| 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood | | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sarcoma, Metastatic, Lung | | 1 |
Mediastinal, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 5 |
Mediastinal, Carcinoma, Metastatic, | | |
Lung | X | 1 |
Mediastinal, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | X X | 2 |
Serosa, Mediastinal, Sarcoma, | | |
Metastatic, Uncertain Primary | | |
Site | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Leukemia | | 1 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Leukemia | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia | | 1 |
Leukemia Mononuclear | X X X X | 6 |
Squamous Cell Carcinoma, Metastatic, | | |
Lung | X | 1 |
__________________________________________________________________________|____________|
Thymus | + M + + + + M M + + + + + M + + + + + + M + + + +| 42 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X X | 4 |
Leukemia | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
Fibroadenoma | X X X| 4 |
Fibroadenoma, Two | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7| |
DAY ON TEST | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2| |
| 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Keratoacanthoma | X | 1 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, | | |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic | X | 1 |
Subcutaneous Tissue, | | |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Subcutaneous Tissue, Fibroma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Astrocytoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X | 3 |
Alveolar/Bronchiolar Carcinoma | X | 3 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X X X X X X X X X X X X X X X X X X X X X X X| 44 |
Alveolar/Bronchiolar Carcinoma, Two | X | 3 |
Leukemia | | 1 |
Leukemia Mononuclear | X X X X | 5 |
Mixed Tumor Malignant, Multiple | | 1 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Sarcoma, Multiple | X | 1 |
Squamous Cell Carcinoma | X X X X | 10 |
Squamous Cell Carcinoma, Multiple | X | 2 |
Mediastinum, Carcinoma, Metastatic, | | |
Lung | X | 1 |
Mediastinum, Leukemia | | 1 |
Mediastinum, Squamous Cell Carcinoma,| | |
Metastatic, Lung | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| 5| 7| 5| 7| 6| 4| 7| 6| 7| |
DAY ON TEST | 2| 8| 4| 2| 9| 6| 2| 1| 2| 6| 2| 2| 2| 2| 9| 6| 8| 2| 3| 2| 9| 7| 2| 6| 2| |
| 2| 9| 6| 8| 5| 7| 8| 9| 0| 7| 8| 8| 8| 8| 6| 0| 4| 8| 4| 8| 5| 5| 8| 5| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Pleura, Mediastinum, Sarcoma, | | |
Metastatic, Uncertain Primary | | |
Site | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple, Metastatic, Lung | X | 2 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X X X | 7 |
Carcinoma, Metastatic, Lung | X | 1 |
Leukemia | | 1 |
Leukemia Mononuclear | | 1 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Sarcoma, Metastatic, Lung | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + M +| 48 |
Leukemia | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia | | 1 |
Leukemia Mononuclear | X X X X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 8| 1| 2| 2| 5| 2| 2| 1| 2| 0| 2| 2| 8| 2| 2| 6| 2| 2| 8| 2| 2| 2| 2| 4| 3|
| 4| 6| 7| 7| 9| 7| 7| 9| 7| 6| 8| 8| 7| 8| 8| 3| 8| 8| 1| 9| 9| 9| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + M + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Mesentery | + + + + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X|
Pars Distalis, Adenoma, Two | X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 8| 1| 2| 2| 5| 2| 2| 1| 2| 0| 2| 2| 8| 2| 2| 6| 2| 2| 8| 2| 2| 2| 2| 4| 3|
| 4| 6| 7| 7| 9| 7| 7| 9| 7| 6| 8| 8| 7| 8| 8| 3| 8| 8| 1| 9| 9| 9| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + M + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Deciduoma Benign | X |
Polyp Stromal | X X X X |
Polyp Stromal, Two | |
Sarcoma Stromal | X |
Bilateral, Polyp Stromal | X |
__________________________________________________________________________|
Vagina | |
Schwannoma Malignant, Metastatic, | |
Urinary Bladder | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Fibroadenoma | X X X X X X X |
Fibroadenoma, Two | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
Basosquamous Tumor Malignant | |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 8| 1| 2| 2| 5| 2| 2| 1| 2| 0| 2| 2| 8| 2| 2| 6| 2| 2| 8| 2| 2| 2| 2| 4| 3|
| 4| 6| 7| 7| 9| 7| 7| 9| 7| 6| 8| 8| 7| 8| 8| 3| 8| 8| 1| 9| 9| 9| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | X X X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma, Two | X X X X |
Chordoma, Metastatic, Uncertain | |
Primary Site | |
Leukemia Mononuclear | X X X X |
Squamous Cell Carcinoma | X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | |
Transitional Epithelium, Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 7| 0| 2| 2| 2| 0| 2| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 9| 9| 9| 7| 3| 9| 9| 9| 3| 8| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Adenoma | X | 1 |
Leukemia Mononuclear | X X X X | 8 |
__________________________________________________________________________|____________|
Mesentery | | 6 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | | 1 |
Pheochromocytoma Benign | X X X | 3 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + M + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + I + + + + + + A + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 4 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X| 27 |
Pars Distalis, Adenoma, Two | X | 2 |
Pars Distalis, Carcinoma | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 7| 0| 2| 2| 2| 0| 2| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 9| 9| 9| 7| 3| 9| 9| 9| 3| 8| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Adenoma | X X | 6 |
C-Cell, Carcinoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | X X X | 4 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Deciduoma Benign | | 1 |
Polyp Stromal | X X X X | 8 |
Polyp Stromal, Two | X | 1 |
Sarcoma Stromal | | 1 |
Bilateral, Polyp Stromal | X X | 3 |
__________________________________________________________________________|____________|
Vagina | + | 1 |
Schwannoma Malignant, Metastatic, | | |
Urinary Bladder | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pancreatic, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 10 |
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | | 1 |
Fibroadenoma | X X X X | 11 |
Fibroadenoma, Two | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 7| 0| 2| 2| 2| 0| 2| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 9| 9| 9| 7| 3| 9| 9| 9| 3| 8| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basal Cell Adenoma | X | 1 |
Basosquamous Tumor Malignant | X | 1 |
Squamous Cell Papilloma | X | 2 |
Subcutaneous Tissue, Fibroma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X| 6 |
Alveolar/Bronchiolar Carcinoma | X X X X X X| 11 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 1 |
Alveolar/Bronchiolar Carcinoma, Two | X X X | 7 |
Chordoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
Leukemia Mononuclear | X | 5 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Schwannoma Malignant | X | 1 |
Transitional Epithelium, Papilloma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 7| 7| 7| 4| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 7| 0| 2| 2| 2| 0| 2| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 9| 9| 9| 7| 3| 9| 9| 9| 3| 8| 9| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Mononuclear | X X X X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 7| 5| 4| 6| 2| 6| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6|
DAY ON TEST | 2| 6| 2| 5| 9| 4| 2| 4| 0| 2| 4| 2| 8| 0| 2| 2| 4| 2| 2| 2| 2| 1| 4| 2| 1|
| 7| 3| 2| 8| 4| 4| 4| 6| 7| 7| 9| 7| 6| 8| 3| 7| 5| 7| 7| 8| 8| 8| 4| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + M + A + A + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Lymphoma Malignant | |
Mesothelioma Malignant | X|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + A + + + + + A + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + A + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Leiomyosarcoma | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Multiple, Metastatic,| |
Intestine Small | |
Hepatocellular Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
Lymphoma Malignant | |
__________________________________________________________________________|
Mesentery | +|
Hemangioma | |
Leukemia Mononuclear | |
Mesothelioma Malignant | X|
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Lymphoma Malignant | |
Mesothelioma Malignant | X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X|
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + + |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 7| 5| 4| 6| 2| 6| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6|
DAY ON TEST | 2| 6| 2| 5| 9| 4| 2| 4| 0| 2| 4| 2| 8| 0| 2| 2| 4| 2| 2| 2| 2| 1| 4| 2| 1|
| 7| 3| 2| 8| 4| 4| 4| 6| 7| 7| 9| 7| 6| 8| 3| 7| 5| 7| 7| 8| 8| 8| 4| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M M + + + + + + + M + M + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X X |
Carcinoma, Two | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + M + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X|
Pars Distalis, Adenoma, Two | X X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X X|
Bilateral, Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
__________________________________________________________________________|
Seminal Vesicle | + + M + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X X|
Bilateral, Mesothelioma Malignant | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 7| 5| 4| 6| 2| 6| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6|
DAY ON TEST | 2| 6| 2| 5| 9| 4| 2| 4| 0| 2| 4| 2| 8| 0| 2| 2| 4| 2| 2| 2| 2| 1| 4| 2| 1|
| 7| 3| 2| 8| 4| 4| 4| 6| 7| 7| 9| 7| 6| 8| 3| 7| 5| 7| 7| 8| 8| 8| 4| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Leukemia Mononuclear | X X X X X |
Mediastinal, Lymphoma Malignant | |
Pancreatic, Leukemia Mononuclear | X X X |
Pancreatic, Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + M + + M + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Lymphoma Malignant | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
Lymphoma Malignant | |
Mesothelioma Malignant | X|
__________________________________________________________________________|
Thymus | + + M + A + + + M M + M M + + M + M + + + + + M +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + M + + + + + M + + M M + M + + + + + + M +|
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | X |
Basal Cell Carcinoma | |
Keratoacanthoma | X |
Subcutaneous Tissue, Fibroma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + M + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X |
Lymphoma Malignant | |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 7| 5| 4| 6| 2| 6| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 7| 6|
DAY ON TEST | 2| 6| 2| 5| 9| 4| 2| 4| 0| 2| 4| 2| 8| 0| 2| 2| 4| 2| 2| 2| 2| 1| 4| 2| 1|
| 7| 3| 2| 8| 4| 4| 4| 6| 7| 7| 9| 7| 6| 8| 3| 7| 5| 7| 7| 8| 8| 8| 4| 3| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mediastinum, Leukemia Mononuclear | X |
__________________________________________________________________________|
Nose | + + + + A + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Lymphoma Malignant | |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
Lymphoma Malignant | |
Mesothelioma Malignant | X X X|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2| |
| 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + M + + + + + + + + + + + + + + + + + +| 45 |
Leukemia Mononuclear | X | 1 |
Lymphoma Malignant | X | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Adenocarcinoma | X | 1 |
Leiomyosarcoma | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma, Multiple, Metastatic,| | |
Intestine Small | X | 1 |
Hepatocellular Carcinoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X | 24 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Hemangioma | X | 1 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 2 |
Lymphoma Malignant | X | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Tongue | | 2 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2| |
| 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | X X X X X X X X | 12 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X X | 3 |
Carcinoma | X X | 4 |
Carcinoma, Two | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 3 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X | 27 |
Pars Distalis, Adenoma, Two | | 2 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Adenoma | X | 3 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mesothelioma Malignant | | 2 |
Bilateral, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Carcinoma | X | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Adenocarcinoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2| |
| 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + M + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant | | 2 |
Bilateral, Mesothelioma Malignant | | 1 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X| 19 |
Interstitial Cell, Adenoma | X X X X X X X | 14 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X | 9 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Leukemia Mononuclear | X X X X X X | 11 |
Mediastinal, Lymphoma Malignant | X | 1 |
Pancreatic, Leukemia Mononuclear | X X X X | 7 |
Pancreatic, Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X | 12 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X X X X | 12 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X | 26 |
Lymphoma Malignant | X | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + + M + + M + + + M + + + + + + + + + + + M + + | 36 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 43 |
Fibroadenoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basal Cell Adenoma | | 1 |
Basal Cell Carcinoma | X | 1 |
Keratoacanthoma | X | 2 |
Subcutaneous Tissue, Fibroma | X X | 4 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 4| 6| 6| 6| 7| 5| 6| 7| 5| 7| 4| 6| 6| 6| 7| 6| 4| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 2| 0| 4| 4| 6| 2| 4| 6| 2| 6| 2| 9| 7| 9| 0| 2| 5| 8| 2| 2| 2| |
| 8| 8| 8| 8| 9| 1| 4| 6| 1| 9| 6| 0| 7| 9| 7| 2| 1| 4| 4| 7| 3| 3| 0| 7| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X | 23 |
Lymphoma Malignant | X | 1 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | X | 1 |
Mediastinum, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X | 27 |
Lymphoma Malignant | X | 1 |
Mesothelioma Malignant | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|
DAY ON TEST | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|
| 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Small, Ileum | + M + A + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + M + + + + + + + +|
Mesothelioma Malignant | X |
Polyp Adenomatous | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + |
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
Acinus, Adenoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Adventitia, | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X X X |
Leukemia Mononuclear | X X |
Squamous Cell Carcinoma, Metastatic, | |
Lung | X |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|
DAY ON TEST | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|
| 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
Medulla, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Leukemia Mononuclear | X |
Neuroblastoma Benign | X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X |
Pheochromocytoma Benign, Multiple | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Carcinoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + + M + M + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X |
Pars Distalis, Adenoma, Two | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | X X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Squamous Cell Carcinoma, Metastatic, | |
Lung | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|
DAY ON TEST | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|
| 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Mesothelioma Malignant | X X |
Bilateral, Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + M + + + + M + + + + + + + + A + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
Bilateral, Mesothelioma Malignant | X X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | |
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Mediastinal, Leukemia Mononuclear | X X X X |
Pancreatic, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + M + + + M + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Leukemia Mononuclear | X |
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + M +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Leukemia Mononuclear | X X X X X X X X|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + M + M + + M + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + M + + M + +|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|
DAY ON TEST | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|
| 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Adenoma | |
Fibroadenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Lipoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Carcinoma | X X|
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X X X X X X X X X X X X X X X X X X |
Alveolar/Bronchiolar Carcinoma, Two | X |
Leukemia Mononuclear | X X X X X X|
Sarcoma | X |
Squamous Cell Carcinoma | X X X X X X X X |
Squamous Cell Carcinoma, Two | X X |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Mediastinum, Leukemia Mononuclear | X |
Pleura, Mediastinum, | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 6| 5| 6| 5| 5| 6| 5| 7| 6| 5| 5| 5| 6| 5| 6| 6| 7| 5| 5| 5| 6|
DAY ON TEST | 2| 2| 4| 0| 5| 0| 7| 4| 9| 0| 7| 2| 5| 0| 4| 6| 8| 1| 3| 9| 2| 4| 4| 4| 0|
| 9| 8| 9| 8| 7| 0| 4| 7| 0| 9| 3| 8| 9| 6| 1| 2| 5| 3| 2| 4| 3| 6| 7| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X X |
Leukemia Mononuclear | |
Squamous Cell Carcinoma, Metastatic, | |
Lung | X |
Capsule, Mesothelioma Malignant | X |
__________________________________________________________________________|
Ureter | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
Mesothelioma Malignant | X X X |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5| |
DAY ON TEST | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4| |
| 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + +| 46 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + M + + + + + + + A + + + + + + + + +| 45 |
Mesothelioma Malignant | | 1 |
Polyp Adenomatous | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X | 19 |
__________________________________________________________________________|____________|
Mesentery | + +| 6 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X X X X X | 6 |
Leukemia Mononuclear | X X | 2 |
Mesothelioma Malignant | | 1 |
Acinus, Adenoma | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + +| 2 |
Aorta, Adventitia, | | |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5| |
DAY ON TEST | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4| |
| 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X X | 5 |
Leukemia Mononuclear | X X X X | 6 |
Squamous Cell Carcinoma, Metastatic, | | |
Lung | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X X X | 3 |
Leukemia Mononuclear | X X | 3 |
Mesothelioma Malignant | | 1 |
Medulla, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 2 |
Leukemia Mononuclear | X | 2 |
Neuroblastoma Benign | | 1 |
Pheochromocytoma Malignant | X| 1 |
Pheochromocytoma Benign | X X X X | 7 |
Pheochromocytoma Benign, Multiple | X X| 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X X X X | 6 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Carcinoma | X X | 4 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + M +| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Leukemia Mononuclear | X | 2 |
Pars Distalis, Adenoma | X X X X X X X X X X| 16 |
Pars Distalis, Adenoma, Two | X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | X | 3 |
Follicular Cell, Carcinoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5| |
DAY ON TEST | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4| |
| 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Lung | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant | | 2 |
Bilateral, Mesothelioma Malignant | X X | 3 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + M + +| 46 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant | | 1 |
Bilateral, Mesothelioma Malignant | X X | 4 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X | 23 |
Interstitial Cell, Adenoma | X X X X X X X X | 16 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X | 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | X | 1 |
Mediastinal, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
Mediastinal, Leukemia Mononuclear | X X X X X X | 10 |
Pancreatic, Leukemia Mononuclear | X X X X X | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +| 46 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Leukemia Mononuclear | X X X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5| |
DAY ON TEST | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4| |
| 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X X X X | 12 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 22 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + + + M + + + M + + +| 43 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X X | 4 |
Leukemia Mononuclear | X X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Adenoma | X | 1 |
Fibroadenoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibroma | X | 3 |
Subcutaneous Tissue, Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X X X | 11 |
Alveolar/Bronchiolar Carcinoma | X X | 4 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X X X X X X X X X X X X X X X X X| 35 |
Alveolar/Bronchiolar Carcinoma, Two | X X X X X X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 6| 5| 6| 6| 4| 5| 6| 6| 6| 6| 7| 5| 5| 7| 6| 6| 7| 6| 6| 6| 5| 5| |
DAY ON TEST | 6| 0| 7| 3| 1| 1| 1| 9| 7| 5| 9| 7| 5| 2| 3| 2| 2| 9| 3| 1| 0| 0| 0| 4| 4| |
| 2| 6| 3| 2| 8| 0| 8| 7| 6| 3| 8| 4| 3| 8| 2| 1| 8| 6| 8| 0| 4| 5| 1| 8| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X X X X X X X X | 16 |
Sarcoma | | 1 |
Squamous Cell Carcinoma | X X X X X X | 14 |
Squamous Cell Carcinoma, Two | X X X | 5 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
Mediastinum, Leukemia Mononuclear | X | 2 |
Pleura, Mediastinum, | | |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + + | 4 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X X X | 5 |
Leukemia Mononuclear | X X | 2 |
Squamous Cell Carcinoma, Metastatic, | | |
Lung | X | 2 |
Capsule, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Ureter | + | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X X X X | 22 |
Mesothelioma Malignant | X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|
DAY ON TEST | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|
| 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + + + A + +|
Leukemia Mononuclear | |
Peyer's Patch, Fibrous Histiocytoma | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + M + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Multiple, Metastatic, Lung | X |
Fibrous Histiocytoma | |
Hepatocellular Adenoma | |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X |
Neoplastic Nodule | X |
Serosa, Mesothelioma Malignant | X |
__________________________________________________________________________|
Mesentery | + + + + |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|
DAY ON TEST | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|
| 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Metastatic, Lung | X X |
Fibrous Histiocytoma | |
Leukemia Mononuclear | |
Epicardium, Carcinoma, Metastatic, | |
Uncertain Primary Site | |
Epicardium, Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Leukemia Mononuclear | |
Medulla, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X X X |
Pheochromocytoma Benign, Multiple | |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Adenoma | X|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X|
Pars Distalis, Adenoma, Two | X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|
DAY ON TEST | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|
| 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Bilateral, Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Seminal Vesicle | + + + + M + + + + + + + + + + + + + + + + + + +|
Bilateral, Mesothelioma Malignant | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
Bilateral, Mesothelioma Malignant | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | |
Inguinal, Leukemia Mononuclear | |
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
Mediastinal, Histiocytic Sarcoma | |
Mediastinal, Leukemia Mononuclear | X X X X X X X X |
Mediastinal, Mesothelioma Malignant | X |
Pancreatic, Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + M + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + M + + M + + + + + + + + M + + M + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
Keratoacanthoma | X |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|
DAY ON TEST | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|
| 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Squamous Cell Papilloma | |
Trichoepithelioma | |
Subcutaneous Tissue, Fibroma | X X |
Subcutaneous Tissue, Lipoma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periosteum, Femur, Fibrous | |
Histiocytoma | |
Right, Femur, Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | |
Hindlimb, Fibrous Histiocytoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granular Cell Tumor Benign | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X |
Alveolar/Bronchiolar Carcinoma | X X X X X X X X X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X X |
Alveolar/Bronchiolar Carcinoma, Two | X X |
Fibrous Histiocytoma | |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X |
Squamous Cell Carcinoma | |
Mediastinum, Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + A |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 4| 7| 6| 7| 5| 7| 6| 7| 6| 6| 6| 6| 5| 7| 6| 7| 5| 6| 5| 6| 6|
DAY ON TEST | 8| 2| 2| 5| 8| 2| 8| 2| 6| 2| 9| 2| 8| 7| 1| 0| 9| 2| 3| 0| 4| 5| 4| 3| 6|
| 7| 7| 7| 6| 6| 7| 7| 7| 0| 7| 2| 8| 8| 5| 9| 5| 8| 8| 3| 8| 7| 9| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
2 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Leukemia Mononuclear | |
Bilateral, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
Capsule, Histiocytic Sarcoma | |
Capsule, Mesothelioma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X |
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2| |
| 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + A + + +| 47 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Adenocarcinoma | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + + + A + + A + + +| 45 |
Leukemia Mononuclear | X | 1 |
Peyer's Patch, Fibrous Histiocytoma | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A A + A + + + + + + A + + A + + +| 42 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple, Metastatic, Lung | | 1 |
Fibrous Histiocytoma | X | 1 |
Hepatocellular Adenoma | X | 1 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X| 22 |
Neoplastic Nodule | | 1 |
Serosa, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + M + + + + + + + + A + + + + + +| 48 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Histiocytic Sarcoma | X | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + M + + + + + + + + + + + + + + A + + + + + +| 47 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2| |
| 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 3 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 3 |
Fibrous Histiocytoma | X | 1 |
Leukemia Mononuclear | X X X | 3 |
Epicardium, Carcinoma, Metastatic, | | |
Uncertain Primary Site | X | 1 |
Epicardium, Histiocytic Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Adenoma | X | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Leukemia Mononuclear | X | 1 |
Medulla, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + A + + + + + +| 47 |
Leukemia Mononuclear | X | 1 |
Pheochromocytoma Malignant | X X | 2 |
Pheochromocytoma Benign | X X X X X X X X | 14 |
Pheochromocytoma Benign, Multiple | X | 1 |
Bilateral, Pheochromocytoma Benign | X| 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + M + + + + + + + + A + + + + + +| 48 |
Adenoma | X X X X| 5 |
Carcinoma | X X | 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Leukemia Mononuclear | X| 4 |
Pars Distalis, Adenoma | X X X X X X X X X X| 22 |
Pars Distalis, Adenoma, Two | X | 2 |
Pars Distalis, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
C-Cell, Adenoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 51
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2| |
| 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Carcinoma | X | 2 |
Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 |
Bilateral, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant | | 1 |
Bilateral, Mesothelioma Malignant | | 1 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X| 23 |
Interstitial Cell, Adenoma | X X X X X X X X | 15 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Leukemia Mononuclear | X X X | 8 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Leukemia Mononuclear | X | 1 |
Inguinal, Leukemia Mononuclear | X| 1 |
Mediastinal, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X X | 3 |
Mediastinal, Histiocytic Sarcoma | X | 1 |
Mediastinal, Leukemia Mononuclear | X X X| 11 |
Mediastinal, Mesothelioma Malignant | | 1 |
Pancreatic, Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M M + + + + + + + + M + + M + + +| 44 |
Fibrous Histiocytoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2| |
| 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X| 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X| 14 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X X X| 26 |
__________________________________________________________________________|____________|
Thymus | + + + + + + M + M + + + + + + + + + + + + M + +| 42 |
Leukemia Mononuclear | X X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + M + +| 46 |
Leukemia Mononuclear | X| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Basal Cell Adenoma | X | 1 |
Keratoacanthoma | X| 2 |
Squamous Cell Papilloma | X | 1 |
Trichoepithelioma | X | 1 |
Subcutaneous Tissue, Fibroma | | 2 |
Subcutaneous Tissue, Lipoma | X| 1 |
Subcutaneous Tissue, Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Periosteum, Femur, Fibrous | | |
Histiocytoma | X | 1 |
Right, Femur, Osteosarcoma | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Hindlimb, Fibrous Histiocytoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granular Cell Tumor Benign | X | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X X | 11 |
Alveolar/Bronchiolar Adenoma, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05072-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TETRANITROMETHANE Date: 04/16/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:46:05
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 3| 7| 5| 5| 6| 6| 7| |
DAY ON TEST | 2| 3| 2| 2| 7| 7| 0| 2| 9| 2| 6| 8| 2| 2| 2| 9| 2| 2| 5| 2| 3| 3| 1| 7| 2| |
| 8| 5| 8| 8| 5| 4| 7| 8| 9| 6| 1| 1| 9| 9| 9| 1| 9| 9| 3| 9| 5| 3| 9| 5| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
2 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Multiple | | 2 |
Alveolar/Bronchiolar Carcinoma | X X X X X X X | 18 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X X | 4 |
Alveolar/Bronchiolar Carcinoma, Two | X X| 4 |
Fibrous Histiocytoma | X | 1 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X| 17 |
Squamous Cell Carcinoma | X | 1 |
Mediastinum, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + | 2 |
Squamous Cell Papilloma | X X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Leukemia Mononuclear | X X | 2 |
Bilateral, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
Capsule, Histiocytic Sarcoma | X | 1 |
Capsule, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X X X| 26 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
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